A New Piece Added to the Pituitary Gland Puzzle Revises Evolutionary History – Technology Networks

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A new USC-led study suggests a change to the developmental -- and evolutionary -- story of the pituitary gland.

The pea-sized gland, nestled at the base of the brain, produces hormones that drive growth, aggression, sexual development and reproduction. For decades, the front lobe of the pituitary -- where the hormones are made -- was thought to be an evolutionary development that arose in vertebrates, along with the ear, the nose and the lens of the eye.

The widely accepted "new head hypothesis" holds that all of these body parts derive from a particular type of embryonic structure located in the ectoderm, or outermost layer of an embryo. Meanwhile, animals that have spinal cords but lack backbones, understood to represent an earlier evolutionary step, have a pituitary-like structure previously thought to have a distinct origin in the innermost embryonic layer, or endoderm.

In a paper published today in Science, USC researchers present evidence that, in some vertebrates, the endoderm also forms part of the pituitary's front lobe -- an idea that has been the subject of scientific controversy dating back more than 100 years. Findings from the study, which was supported by a major grant from the National Institutes of Health, suggest that the gland may have a longer evolutionary history than previously thought.

"We revisited very old observations with cutting-edge technology that proves this idea that there is an endodermal contribution to the pituitary," said senior author Gage Crump, professor of stem cell and regenerative medicine at the Keck School of Medicine of USC. "Our work revises ideas about what kind of embryonic structure the pituitary is, and when it first evolved." Developmental detective work

Crump and his colleagues studied zebrafish, a species useful as a lab model in part because their development is an open book to researchers; eggs are fertilized externally and embryos are nearly see-through. The research team used new lab methods of their own invention to label the zebrafish's embryonic cells and follow the cells that descended from them through adulthood.

Additionally, they used time-lapse imaging with a powerful microscope and single-cell RNA sequencing. That latter technology is related to DNA sequencing, but instead of characterizing the entire genetic code, it reveals only the genes that are expressed, and in what quantities, for each of thousands of cells at a time -- a powerful way of understanding the nature of the cells being studied.

In a series of experiments with time-lapse imaging of zebrafish embryos, the team documented Rathke's pouch, a structure from the outer layer previously believed to be the sole source of the pituitary's front lobe, fusing with Seessel's pouch, a structure from the inner layer. Their observations indicate that the endoderm was responsible for about 20 percent of the cells in the front lobe of the pituitary.

Another experiment tracking the fate of embryonic cells into adult zebrafish showed a mixture of ectodermally and endodermally derived cells in the pituitary. Delving into gene expression with RNA sequencing, the scientists found that cells from the inner endoderm layer ended up differentiating into all of the major types of hormone-producing cells in the pituitary. Furthermore, in genetically manipulated zebrafish embryos that lacked the ectodermal component , endodermal cells could form a pituitary-like structure on their own, albeit much smaller than the normal pituitary.

Taken together, these investigations clearly demonstrate an endodermal contribution to the zebrafish pituitary. This unexpected revelation suggests that the quasi-pituitary seen in certain more-primal nonvertebrate animals -- undersea creatures that are strange and largely obscure -- may have survived, in a form, among at least some of their backbone-bearing evolutionary descendants.

Crump, who also is the founding director of USC's PhD Program in Development, Stem Cells, and Regenerative Medicine, cautions that it remains to be seen whether the vestige endures in humans.

"It may be that fish retain this ancestral feature, but humans have lost it," he said. "We can see the pituitary is not a brand-new vertebrate structure like the nose or ear or lens, but instead was already present before vertebrates and subsequently incorporated new ectoderm contributions. By capturing this evolutionary relic in zebrafish, we have resolved the mystery of where the pituitary came from."

An old idea that came back around (surprisingly)

As far back as the mid-1910s, anatomists had reported that Rathke's pouch was closely associated with Seessel's pouch. Rathke's pouch has long been understood as the source of the pituitary's endocrine component. By contrast, the fate and purpose of Seessel's pouch has remained a mystery -- until today.

For researchers in the early 20th century (and more or less ever since), there were no good ways to further explore the relation between the two embryonic structures, and thus the possibility of an endodermal contribution to the pituitary. Hotly debated at first, the topic eventually faded into more of a historical curiosity.

Fortunately, first author Peter Fabian, a postdoctoral researcher at the Keck School, was well-versed in this precedent. While trying out one of those new techniques for labeling and tracking embryonic cells, developed by collaborators at Sanford Burnham Prebys Medical Discovery Institute, he noticed endodermal cells in the pituitary. A light bulb went off in his head.

"It was a serendipitous discovery," Crump said. "We're interested in the endoderm in general, but we hadn't set out to study the pituitary. Because this was such an unexpected observation, we really had to prove it with multiple lines of investigation."

Reference: Fabian P, Tseng KC, Smeeton J, et al.Lineage analysis reveals an endodermal contribution to the vertebrate pituitary.Science. 2020;370(6515)463-467. doi:10.1126/science.aba4767

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Biobanks Market Analysis Growth Opportunities and Trends by Forecast To 2025 – The Think Curiouser

Global Biobanks Market: Snapshot

Biobanks are essentially repositories for storing biological substances derived from humans, which may include organs, bio-specimens, plasma, saliva, and blood. With a vast rise in the number of organ replacement surgeries globally and significant advancements made in the fields of transfusion and replacement technologies, the role of the biobanks market has become more concrete in the healthcare sector in recent years.

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The global biobanks market has witnessed expansion at a significant pace in the recent years owing to the vast rise in prevalence of a number of chronic diseases and the increased demand for personal medicine. The massive rise in incidence rate of conditions such as diabetes, cancer, neurovascular diseases, cardiovascular diseases, and respiratory diseases has compelled government bodies to take stronger actions in terms of investments in biobanks and increasing awareness about them. The global market for biobanks works in coherence with these efforts by adding pace to the process of drug discovery and the treatment of chronic diseases that are caused by activities such as smoking, consumption of alcohol, obesity, and unhealthy lifestyles.

Heavy investment by a proactive government has boosted the North America biobanks market to the leading position in the global biobanks market, followed closely by Europe. Both regions are home to several bioscience companies and host a large number of drug discovery and research activities. Asia Pacific still remains the region with the most promising growth potential as the region shown high promise owing to an increase in investments from both government and non-government organizations, along with a large and increasingly affluent population base that is gaining awareness about the market.

Global Biobanks Market: Overview

The global biobanks market owes its conception to the rising need for replacement organs and the steady advancement in the replacement and transfusion technologies regarding a number of bodily substances. Though the technology and need to store organs and other bio-entities had been available for a long time, the global biobanks market took on a more important role in the healthcare sector following the increasing research in genomics. In the new millennium, the development of the personalized medicine field has been the vital driver for the global biobanks market. The likely advancement of the latter, thanks to helpful government regulations, is likely to make the crucial difference for the global biobanks market in the near future.

The steady technological advancement in the healthcare sector in the last few decades has now led to a scenario where the full potential of biobanks can be harnessed. As a result, the global biobanks market is projected to exhibit steady growth over the coming years.

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Global Biobanks Market: Key Trends

The rising interest in personalized medicine is the prime driver for the global biobanks market. Personalized medicine has only become a viable branch of modern medicine after steady research in genomics and the way various patients react to various medicines. The biobanks market has thus come into the spotlight thanks to their role as a steady supplier of human biomaterials for research as well as direct application. The increasing research in genomics following the findings of the Human Genome Project is thus likely to remain a key driver for the global biobanks market in the coming years.

The utilization of biobanks instem cellresearch has been hampered in several regions by ethical concerns regarding the origin of stem cells. Nevertheless, the potential of stem cells in the healthcare sector is immense, and is likely to have a decisive impact on the trajectory of the global biobanks market in the coming years. Many countries have, in recent years, adopted a supportive stance towards stem cell research, aiding the growth of the biobanks market. Continued government support is thus likely to remain vital for the global biobanks market in the coming years.

Global Biobanks Market: Market Potential

The leading role of the U.S. in the global biobanks market is unlikely to change in the coming years. The easy availability of government-supported healthcare infrastructure and the presence of several industry giants in the region has driven the biobanks market in the U.S.

Northwell Health, the largest healthcare provider in New York State, earlier in 2017 initiated a new biobank aimed at creating precision therapies against various types of cancer. Launched in collaboration with Indivumed, the biobank will provide catalogued biomaterials for research into lung, colorectal, breast, and pancreatic cancer. This would enable targeted, gene-specific studies of a variety of cancer samples, leading to a more comprehensive understanding of cancer. Such well-funded collaboration efforts are crucial for the developing biobanks market.

Global Biobanks Market: Geographical Dynamics

Led by the fertile healthcare research scenario in the U.S., North America is likely to retain a dominant share in the global biobanks market in the coming years. Steady support from institutes such as the NIH is likely to be vital for the North America biobanks market.

Emerging Asia Pacific economies such as India and China could emerge with a significant share in the global biobanks market in the coming years. The healthcare sector in both countries has received steady public or private funding in the last few years. India is also a global leader in medical tourism and is likely to receive an increasing number of patients in the coming years, leading to promising prospects for the global biobanks market in the region.

Global Biobanks Market: Competitive Dynamics

Due to the dynamic nature of the global biobanks market, with advancements in diagnostic fields often determining the direction of the market, the market is heavily fragmented. It is likely to retain a significant degree of fragmentation in the coming years thanks to the diversity in the application segments of the biobanks market. The leading players in the global biobanks market include BioCision, Tecan Group, VWR, Beckman Coulter Inc., and Thermo Fisher Scientific.

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Biobanks Market Analysis Growth Opportunities and Trends by Forecast To 2025 - The Think Curiouser

Cell Isolation Market Global Industry Trends and Forecast to 2026 | Miltenyi Biotec, Merck KGaA, BD Biosciences, STEMCELL Technologies Inc., Thermo…

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The Global Cell Isolation market is anticipated to reach XX USD billion with CAGR of xx% over the forecast period 2020 2026.

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Prop 14: Don’t Stand Idly By – Jewish Journal

At the very heart of our Biblical tradition is this commandment from the Book of Leviticus: You shall not stand idly by the blood of your fellow. (Leviticus 19:16)

If we see our sisters or brothers in danger, our job is simple: provide that help, come to their aid, do what is in our power to protect them and save them.

In the midst of a global pandemic, we feel the call to protect and promote the health and well-being of others even more urgently. Right now, we hear the call to uphold the ultimate Jewish value of pikuach nefesh (saving a life).

Sometimes, we live out that value in an immediate way. We donate blood today, which can save lives in real time. We provide support for basic needs to ensure that people in our community have enough to eat right now. But if we truly wish to move the needle in the work of pikuach nefesh, we must also provide resources to fund research over many years, even decades, that will, ultimately, yield dramatic results.

To truly make a difference, to be Gods partners in bringing healing to the world, we must not stand idly by in both immediate and long-term ways.

California voters have an opportunity to do just this by voting Yes on Proposition 14, which will advance the California Institute of Regenerative Medicines stem cell research to help those who are affected by ailments including heart disease, diabetes, Alzheimers, Parkinsons Disease, sickle cell disease, spinal cord injuries, COVID-19, and so many other chronic illnesses and injuries.

Funding for this important and vital medical research help save lives, and it will provide immediate economic stimulus as well. Even as it funds long-term strategies to alleviate human suffering, Proposition 14 will create jobs during this challenging time. Recent studies suggest that Proposition 14 would generate approximately $20 billion in increased economic activity in California, yielding more than 100,000 new jobs at every level. This far surpasses Proposition 14s estimated cost of $5.5 billion in bonds.

Critics of the proposition question the need for such funding on a state level today. They argue that Proposition 71, the initiative that originally created the California Institute of Regenerative Medicine, was passed in 2004 only because President George W. Bush had banned federal funding for stem cell research. Now that federal funding for stem cell research is allowed, the critic charge, its no longer Californias responsibility to fund such research; private and federal funding be used to continue this important work.

However, relying on federal and private funds is too risky. Many in our country wish to stifle and limit stem cell research on religious grounds. Far more importantly, Jewish law on this matter is unequivocal: stem cell research is not just permitted, but, arguably, required as a matter of pikuach nefesh. Numerous halakhic authorities have made this clear. It should, therefore, come as no surprise that some of the most exciting work in stem cell research is currently being done in Israel.

Medical experts agree that stem cell research and therapies will save lives and alleviate human suffering. In fact, it already has. One example is the stem cell Dr. Donald Kohn at UCLA conducted to cure ADA-SCID bubble baby disease.

This work is too important for us to leave it to chance or to allow it to be cut-off or limited. We see Proposition 14s opportunity to provide such resources for life-saving research as a blessing, the fulfillment of core Jewish values. Just one chapter before the commandment to not stand idly by, our Torah reminds us that the purpose of mitzvot, the very goal of Judaism, is to enhance life. We are commanded: in the pursuit of My laws and statutes you shall live ( ). (Leviticus 18:5) The Rabbis of the Talmud interpret this verse to mean that the ultimate value, above all else, is life itself.

To be sure, it will take many years to realize the promise of current research. But like the well-known story of Honi, who came upon an old man planting a tree that would not bear fruit for another seventy years, we recognize that our efforts are not for ourselves alone. Just as our ancestors sacrificed so that our lives would be better, we commit ourselves to doing the same for our descendants.

The voices of our sisters and brothers cry out to us: friends and family members with diabetes; co-workers fighting against cancer; loved ones slipping away due to the cruel ravages of Alzheimers. They call out to us in their pain. They are searching for hope. We cannot stand idly by. We must generously sacrifice so that they and subsequent generations might , live and be well.

There are quite literally lives to be saved. Join us by voting Yes on Proposition 14 on November 3rd.

To learn more, visit http://www.YesOn14.com

Rabbi Sydney Mintz is the Senior Associate Rabbi of Congregation EmanuEl in San Francisco.

Rabbi Yoshi Zweiback is the Senior Rabbi of Stephen Wise Temple in Los Angeles. (Rabbi Zweibacks spouse, Jacqueline Hantgan, isa staffmember for the Prop

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Local researchers make stem cell breakthrough – Times of Malta

Study, shortlisted for German award, could lead to ethical and efficient adult stem cell production at fraction of cost and time

A team of University of Malta researchers has been shortlisted for an international award after conducting breakthrough research that could see the future of adult stem cell production carried out faster and cheaper, and without ethical quandaries.

The team is made up of associate professor Pierre Schembri Wismayer, PhD candidate Ila Tewari Jasra and Maria Mifsud from the Department of Anatomy in the Faculty of Medicine and Surgery.

They have been selected as finalists for a German prize the Falling Walls Life Sciences Award that rewards the top 10 breakthroughs of the year in different scientific fields.

The team built on the Nobel Prize-winning research of Shinya Yamanaka, who in 2006 managed to generate the equivalent of an embryonic stem cell from adult fibroblasts. Yamanaka was able to take a complicated cell and revert it into a younger cell without destroying any embryos

While the process is widely used for research purposes, it is seldom applied to treatment due to the cost and time it takes to produce the stem cells, Schembri Wismayer told Times of Malta.

Stem cell treatment has a big advantage when addressing disease that sees a loss of tissue but its not used so much mostly due to efficiency issues.

While stem cells can be used to cure disease, they are most commonly adult stem cells harvested from fat and bone marrow or from embryonic cells. Apart from being ethically contentious, there is the risk of rejection since it is not the patients own cells that are being used, he explained.

Were hoping that well be able to make stem cells accessible for everyone

Apart from this, genetic modification is a lengthy process with an efficiency rate of less than one per cent. Samples must also be taken from a biopsy, which is quite painful, and requires animal cells to act as feeder cells.

As we know, wherever you have a combination of human and animal cells you also run the risk of diseases, Schembri Wismayer said.

He and Tewari Jasra were able to produce induced pluripotent stem cells with an 80 per cent efficiency rate using simple and widely available chemicals in a fraction of the time it typically takes.

By comparison, the Roslin Institute, which created Dolly the sheep, require between three to four months to create stem cells that sell in the region of 20,000.

The University of Malta researchers were able to make them far more cheaply in the span of three weeks.

Were hoping that well be able to make stem cells accessible for everyone, Schembri Wismayer said.

Potentially we could have a stem cell bank that matched anyone in the population. We could have cells made for them before they even get diseases.

As part of her PhD research, Tewari Jasra has been working on the breakthrough for close to four-and-a-half years.

Thanking the universitys knowledge transfer team, Schembri Wismayer said he hoped recognition for the research would spur on other local academics and convince institutions that there is research worth funding on the island.

I think its very important for Malta to be aware that we can do good science with very little funding, he said.

Ila didnt have a research fund; we had to beg, steal and borrow from so many different sources just for her to be able to do the research.

We are not the only people with ideas; if investment is done right we could move closer to the ideal of an often mentioned but seldom supported knowledge-based economy.

Its very exciting to see that no one is publishing anything close to what weve managed, he continues.

The response were getting is so encouraging. When you write to established journals and institutes and you hear back within a day, you start thinking you know, I actually might have something here.

Independent journalism costs money. Support Times of Malta for the price of a coffee.

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Local researchers make stem cell breakthrough - Times of Malta

Human Embryonic Stem Cells (HESC) Market Size Technological Advancement And Growth Analysis With Forecast To 2025 – The Think Curiouser

The Global Human Embryonic Stem Cells (HESC) Market report by UpMarketResearch.com provides a detailed analysis of the area marketplace expanding; competitive landscape; global, regional, and country-level market size; impact market players; market growth analysis; market share; opportunities analysis; product launches; recent developments; sales analysis; segmentation growth; technological innovations; and value chain optimization. This is a latest report, covering the current COVID-19 impact on the market. The pandemic of Coronavirus (COVID-19) has affected every aspect of life globally. This has brought along several changes in market conditions. The rapidly changing market scenario and initial and future assessment of the impact is covered in the report.

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The Global Human Embryonic Stem Cells (HESC) Market has been divided into product types, application, and regions. These segments provide accurate calculations and forecasts for sales in terms of volume and value. This analysis can help customers increase their business and take calculated decisions.

By Product Types, Totipotent Stem Cells Pluripotent Stem Cells Unipotent Stem Cells

By Applications, Research Clinical Trials Others

By Regions and Countries, Asia Pacific: China, Japan, India, and Rest of Asia Pacific Europe: Germany, the UK, France, and Rest of Europe North America: The US, Mexico, and Canada Latin America: Brazil and Rest of Latin America Middle East & Africa: GCC Countries and Rest of Middle East & Africa

The regional analysis segment is a highly comprehensive part of the report on the global Human Embryonic Stem Cells (HESC) market. This section offers information on the sales growth in these regions on a country-level Human Embryonic Stem Cells (HESC) market.

The historical and forecast information provided in the report span between 2018 and 2026. The report provides detailed volume analysis and region-wise market size analysis of the market.

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Major players in the global Human Embryonic Stem Cells (HESC) Market include ESI BIO Thermo Fisher BioTime MilliporeSigma BD Biosciences Astellas Institute of Regenerative Medicine Asterias Biotherapeutics Cell Cure Neurosciences PerkinElmer Takara Bio Cellular Dynamics International Reliance Life Sciences Research & Diagnostics Systems SABiosciences STEMCELL Technologies Stemina Biomarker Discovery Takara Bio TATAA Biocenter UK Stem Cell Bank ViaCyte Vitrolife

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Celebrities and Astronauts to "Show up for Science" at the NYSCF Gala & Science Fair – WFMZ Allentown

NEW YORK, Oct. 23, 2020 /PRNewswire/ --Hosted by CNN Chief Medical Correspondent Sanjay Gupta, MD and featuring appearances from world-renowned cellist Yo-Yo Ma, former New York Mayor Michael Bloomberg, Whoopi Goldberg, Martha Stewart, actors Annaleigh Ashford, Lilli Cooper, Jesse Tyler Ferguson, Santino Fontana, Victor Garber, Jane Krakowski, Kelli O'Hara, Billy Porter, Seth Rogen, and John Slattery, among others, The New York Stem Cell Foundation Research Institute's first-ever virtual gala is streaming online on the evening of October 27th. Open to the public and free for all who would like to watch, guests can register at http://www.nyscf.org/gala.

Under the theme "Show Up for Science," the program will re-imagine the Science Fair, a signature element of NYSCF's traditional gala at which guests meet and talk with NYSCF Research Institute scientists, turning it into an online experience as special celebrity guests like Garber, Krakowski, andFerguson interview scientists and learn about the latest updates and breakthroughs in stem cell research. The Gala will bring the world of the NYSCF Research Institute laboratories to life, this year in a multi-platform digital experience produced by Broadway Director Scott Ellis with Music by Tree Adams and Andrew Schuyler.

The Gala also honors the three 2020 NYSCF Stem Cell Heroes: internationally renowned architect Frank Gehry; bioethicist and patient advocate Brooke Ellison, PhD, and award-winning architect and designer David Rockwell.

The 2020 NYSCF Research Institute Gala and Science Fair experience will also include NASA astronauts Serena Aun-Chancellor, MD, PhD, and Peggy Whitson, PhD, talking about stem cell research in space and about what this can mean for stem cell research. In Garber's segment, he will talk with NYSCF Senior Vice President of Research Scott Noggle, PhD, on how stem cells can help find a cure for diabetes, while Krakowski will discuss the basics of stem cells and how they are being used to study and fight COVID-19 with NYSCF Vice President, Automation Systems & Stem Cell Biology Daniel Paull, PhD.

The program will also include Ferguson speaking with NYSCF Principal Investigator Laura Andres-Martin, PhD, about NYSCF's new cutting-edge research on women's reproductive cancers, and NYSCF scientists Howard Kim, PhD, and Cecile Terrenoire, PhD will also share an update on NYSCF's macular degeneration stem cell therapy.

The 75-minute program will focus on education about science, using entertainment as a means to help viewers understand scientific concepts. It will also feature a short performance in honor of Frank Gehry by cellist Yo-Yo Ma, and a comedy skit by Fontana and Ashford.

Frank Gehry is perhaps the world's most celebrated living architect, known for his designs of landmark buildings including the Guggenheim Museum in Bilbao, Spain; Walt Disney Concert Hall in Los Angeles; and Fondation Louis Vuitton in Paris. The Los Angeles-based architect, whose buildings are known for the sweeping shapes and dramatic silhouettes, has won the Pritzker Prize, long considered the architecture profession's equivalent of the Nobel, as well as the Praemium Imperiale in Japan and the Gold Medal of the American Institute of Architects and the Gold Medal of the Royal Institute of British Architects. Frank has also dedicated himself to philanthropic work throughout his long career with numerous pro bono design projects in the arts, and he has had a longstanding engagement with medical research. NYSCF is honored to count Frank as a steadfast supporter of its mission to accelerate better treatments and cures for the most devastating diseases of our time through stem cell research.

David Rockwell is the founder and President of the Rockwell Group, an interdisciplinary and innovative architecture and design firm based in New York with offices in Los Angeles and Madrid, with work that ranges from restaurant and hotel design to cultural and educational institutions, theaters, and stage sets, to self-initiated pro bono projects supporting New York City during times of crisis. Ten years ago, David conceptualized the first Science Fair at a NYSCF Gala, and for many years he designed the environment that simulates the NYSCF Research Institute Laboratories and allows benefit guests to meet and mingle with NYSCF scientists. He has received numerous awards and recognition for his groundbreaking work, including a Tony Award in 2016 for set design, and NYSCF is honored to recognize his dedication, creativity, and talent for making cutting-edge science come alive each fall.

Brooke Ellison, PhD, is an Associate Professor at Stony Brook University, and the Director of Education and Ethics at the Stony Brook Stem Cell Facility. An expert in stem cell research policy and ethics, and longtime patient and disability advocate, Brooke has dedicated her professional career to changing the perception of life-saving science. Paralyzed from the neck down and dependent on a ventilator since age eleven following an accident, Brook has surmounted innumerable hurdles to achieve her goals, including serving on the Empire State Stem Cell Board, which designed New York State's stem cell policy. NYSCF is proud to recognize Brooke's tireless efforts to bring the promise of stem cell research to fruition, and for her advocacy for people in need of better solutions.

"Scientific research is more important than ever, particularly now in the midst of a global pandemic," stated NYSCF Research Institute CEO and Founder Susan L. Solomon. "I am thrilled that we are able to bring our research to life through this digital medium, and to honor our three incredible stem cell heroes. Private philanthropy is the fuel that drives our scientific success, and the Gala and Science Fair celebration highlight both the importance of our work and the promise of stem cell research around the world."

About The New York Stem Cell Foundation Research Institute

The New York Stem Cell Foundation (NYSCF) Research Institute is an independent non-profit organization accelerating cures and better treatments for patients through stem cell research. The NYSCF global community includes over 190 researchers at leading institutions worldwide, including the NYSCF Druckenmiller Fellows, the NYSCF Robertson Investigators, the NYSCF Robertson Stem Cell Prize Recipients, and NYSCF Research Institute scientists and engineers. The NYSCF Research Institute is an acknowledged world leader in stem cell research and in developing pioneering stem cell technologies, including the NYSCF Global Stem Cell Array and in manufacturing stem cells for scientists around the globe. NYSCF focuses on translational research in an accelerator model designed to overcome barriers that slow discovery and replace silos with collaboration. For more information, visitwww.nyscf.org.

David McKeon 212-365-7440 dmckeon@nyscf.org

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Celebrities and Astronauts to "Show up for Science" at the NYSCF Gala & Science Fair - WFMZ Allentown

Mesenchymal Stem Cells Market Augmented Expansion to Be Registered by 2020-2025 – Eurowire

The research report on Mesenchymal Stem Cells Market gives thorough insights regarding various key trends that shape the industry expansion with regards to regional perspective and competitive spectrum. Furthermore, the document mentions the challenges and potential restrains along with latent opportunities which may positively impact the market outlook in existing and untapped business spaces. Moreover, it presents the case studies, including the ones related to COVID-19 pandemic, to convey better understanding of the industry to all the interested parties.

The recent market trend of increasingly using Mesenchymal Stem Cells for understanding the development of a disease extensively fuel the growth of this market in the coming years. Another trend that will aid the growth of the global Mesenchymal Stem Cells market is the escalating demand for personalized medicine. Extensive investments are being made by various organizations, pharmaceutical companies, and governments for the research and development of drugs, and this is another trend that is benefiting the growth of the global Mesenchymal Stem Cells market. This is because Mesenchymal Stem Cells techniques enable researchers to compare Mesenchymal Stem Cells changes between disease samples and normal samples. Public health can thus be analyzed as the changes in Mesenchymal Stem Cells are influenced by internal biological system and environment directly.

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The report covers extensive analysis of the key market players in the market, along with their business overview, expansion plans, and strategies. The key players studied in the report include: Advanced Cell Technology Incorporated, Stem cell technologies Inc., Stemedica Cell Technologies, Inc., Cyagen Biosciences Inc., EMD Millipore Corporation, ScienCell Research Laboratories., Cytori Therapeutics Inc., Cell Applications, Inc., Axol Bioscience Ltd., Aastrom Biosciences, BrainStorm Cell Therapeutics., R&D Systems, Inc., Genlantis, Inc., Celprogen, Inc..

Mesenchymal Stem Cells Market Segmentation:

In market segmentation by types of Mesenchymal Stem Cells, the report covers-

Bone Marrow Umbilical Cord Blood Peripheral Blood Lung Tissue Synovial Tissues Amniotic Fluids Adipose Tissues

In market segmentation by applications of the Mesenchymal Stem Cells, the report covers the following uses-

Injuries Drug Discovery Cardiovascular Infraction Others

Regional Analysis for Mesenchymal Stem Cells Market-:

1) North America- (United States, Canada)

2) Europe- (Germany, France, UK, Italy, Russia, Spain, Netherlands, Switzerland, Belgium)

3) Asia Pacific- (China, Japan, Korea, India, Australia, Indonesia, Thailand, Philippines, Vietnam)

4) Middle East & Africa- (Turkey, Saudi Arabia, United Arab Emirates, South Africa, Israel, Egypt, Nigeria)

5) Latin America- (Brazil, Mexico, Argentina, Colombia, Chile, Peru)

The report provides insights on the following pointers :

Market Penetration: Comprehensive information on the product portfolios of the top players in the Supply Chain Analytics market.

Product Development/Innovation: Detailed insights on the upcoming technologies, R&D activities, and product launches in the market

Competitive Assessment: In-depth assessment of the market strategies, geographic and business segments of the leading players in the market

Market Development: Comprehensive information about emerging markets. This report analyzes the market for various segments across geographies

Market Diversification: Exhaustive information about new products, untapped geographies, recent developments, and investments in the Supply Chain Analytics market

NOTE: Our analysis involves the study of the market taking into consideration the impact of the COVID-19 pandemic. Please get in touch with us to get your hands on an exhaustive coverage of the impact of the current situation on the market. Our expert team of analysts will provide as per report customized to your requirement.

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Table of Content

Chapter 1 Mesenchymal Stem Cells Introduction and Market Overview

Chapter 2 Executive Summary

Chapter 3 Industry Chain Analysis

Chapter 4 Global Mesenchymal Stem Cells Market, by Type

Chapter 5 Mesenchymal Stem Cells Market, by Application

Chapter 6 Global Mesenchymal Stem Cells Market Analysis by Regions

Chapter 7 North America Mesenchymal Stem Cells Market Analysis by Countries

Chapter 8 Europe Mesenchymal Stem Cells Market Analysis by Countries

Chapter 9 Asia Pacific Mesenchymal Stem Cells Market Analysis by Countries

Chapter 10 Middle East and Africa Mesenchymal Stem Cells Market Analysis by Countries

Chapter 11 South America Mesenchymal Stem Cells Market Analysis by Countries

Chapter 12 Competitive Landscape

Chapter 13 Industry Outlook

Chapter 14 Global Mesenchymal Stem Cells Market Forecast

Chapter 15 New Project Feasibility Analysis

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Government of Canada invests in regenerative medicine, genomics research to support Canadians’ health – Canada NewsWire

Funding will help fight cancer and blood disorders and address environmental and agricultural challenges

OTTAWA, ON, Oct. 26, 2020 /CNW/ - As the Government of Canada focuses on responding to the challenges of COVID-19, the importance of investing in science and research is clearer than ever. These investments allow researchers to produce the breakthroughs that improve our daily lives, from delivering cutting-edge therapeutics for treating diseases and chronic conditions to developing new technologies that will help Canadian farmers better protect their crops and livestock.

Today, William Amos, Parliamentary Secretary to the Minister of Innovation, Science and Industry (Science), on behalf of the Honourable Navdeep Bains, Minister of Innovation, Science and Industry, announced an investment of more than $20 million to support advances in stem cell and regenerative medicine and support genomics research.

Today's investments include:

Quotes

"The Government of Canada is proud to support Canada's world-leading stem cell and genomics research community. Today's investment has the potential to save lives and come up with new ways of solving environmental and agricultural challenges. This is Canadian science and innovation in action." William Amos, Parliamentary Secretary to the Minister of Innovation, Science and Industry (Science)

"The health and safety of Canadians remains the government's top priority, and the COVID-19 pandemic has illustrated the continued importance of investing in science and research. I would like to extend my congratulations and gratitude to today's recipients, who continue to work so tirelessly to improve the lives of Canadians. The Government of Canada is committed to supporting science and research, which has far-reaching impacts on Canadians' health and day-to-day lives." The Honourable Navdeep Bains, Minister of Innovation, Science, and Industry

"The projects the Stem Cell Network is funding underscore the depth, breadth and innovation of this highly diverse and collaborative community. Thanks to the continued, long-term funding of the Government of Canada, we will continue to deliver leading-edge and viable stem cellbased therapeutics to treat serious illnesses and chronic diseases, for the benefit of all Canadians." Dr. Michael Rudnicki, O.C., FRS, FRSC, Scientific Director & CEO, Stem Cell Network

"Research will be a key driver of Canada's economic recovery and long-term prosperity. Investments in leading genomics research and technology will support the development of sustainable agriculture, more resilient food systems, healthier communities and a greener resource sector. Genome Canada, in partnership with the Government of Canada, is proud to support collaboration between research institutions and industry that will have transformative impacts on the lives of Canadians." Dr. Rob Annan, President and CEO, Genome Canada

Quick facts

Associated links

For Canadian Science news, follow @CDNScienceon social media: Twitter, Instagram, Facebook Follow Innovation, Science and Economic Development Canada on Twitter: @ISED_CA Follow Stem Cell Network on Twitter: @StemCellNetwork Follow Genome Canada on Twitter: @GenomeCanada

SOURCE Innovation, Science and Economic Development Canada

For further information: John Power, Press Secretary, Office of the Minister of Innovation, Science and Industry, 343-550-1456, [emailprotected]; Media Relations, Innovation, Science and Economic Development Canada, 343-291-1777, [emailprotected]; Janice Nicholson, Director of Communications, Stem Cell Network, 613-402-3974, [emailprotected]; Nicola Katz, Director, Communications, Genome Canada, 613-297-0267, [emailprotected]

http://www.ic.gc.ca/eic/site/icgc.nsf/eng/home

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Government of Canada invests in regenerative medicine, genomics research to support Canadians' health - Canada NewsWire

Five ballot propositions that would affect students – CALmatters

Hundreds of thousands of college and university students are among the Californians expected to cast votes between now and November 3. The number of 18- to 24-year-olds registered to vote in California has climbed by 24% since the last presidential election, and students are finding creative ways to inspire their peers to vote amid the coronavirus pandemic. Heres a rundown of the ballot propositions most likely to impacthigher education, students and other young people. (For more about all of this years ballot propositions, check out CalMatters 2020 Election Guide.)

Student activism was a driving force behind Prop. 16, which would once again allow public colleges to consider race, gender, ethnicity, and national origin in admissions and hiring decisions. California voters passed a constitutional amendment banning the practice, Prop. 209, in 1996.

Enrollment of Black, Latino and Native American students dropped by 25% at UC Berkeley in the wake of the affirmative action ban, and by an average of 12% across the University of California system, according to the university.

While numbers have rebounded somewhat since, those groups are still underrepresented at UC compared with their share of Californias population, a fact cited by student advocates who lobbied Assemblymember Shirley Weber to sponsor a resolution placing affirmative action back on the ballot. It passed the Legislature this summer in the wake of nationwide protests over racial justice.

Were experiencing a civil rights movement again, said Kyndall Dowell, who helped lead the push for Prop. 16 as vice-chair of the UC Student Associations Racial Justice Now campaign. This is the age and decade of having to address colorblindness and the false narratives of racism not existing and people having equal opportunity.

This is the age and decade of having to address colorblindness and the false narratives of racism not existing and people having equal opportunity.

UCs board of regents also supported putting Prop. 16 on the ballot, and the governing boards of California State University and the California Community Colleges have endorsed it. Opposition includes the California College Republicans and Students for Fair Admissions, who sued Harvard over affirmative action admissions policies in 2014, arguing that the university was discriminating against Asian-American students.

California College Republicans is against Democrats push to allow discrimination on the basis of race, sex, color, ethnicity, or national origin in public employment, public education, and public contracting, said the organizations communications director, Dylan Martin. The Republican Party has been against this discrimination historically, as it was Republicans that championed Prop. 209 in 1996.

Some Chinese-American groups have raised similar arguments, saying Prop. 16 could make it harder for qualified Asian-American applicants to win admission to Californias public universities.

U.S. Supreme Court cases have already limited the scope of the use of race in college admissions. Racial quotas, for example, are illegal. But a repeal of Prop. 209 could free up universities for more targeted outreach to diversify the pool of applicants, said OiYan Poon, a professor at Colorado State University who studies affirmative action.

Read more about Prop. 16 here.

Having trouble making the rent for your off-campus room? Youre not alone. The lack of affordable housing near campus was a major motivation behind this springs wildcat strike of University of California graduate students. UC teaching assistants earn an average of $21,000 a year and were pushing for a cost of living adjustment.

Because of our low wages, the rental markets that were forced to live in create a situation where student workers are being priced out of neighborhood after neighborhood, said Ethan Hill, a UCLA doctoral student and organizer with the graduate student union, United Auto Workers Local 2865.

Just how to solve Californias affordable housing crisis is the question behind Prop. 21. Current law only allows local governments to limit rent increases on properties built before 1995. Prop. 21 would also allow rent control on a wider range of properties, including those older than 15 years for landlords who own multiple buildings. While current law allows landlords to increase rent to market price after a tenant moves out, Prop. 21 would allow increases of only up to 15%.

Keep tabs on the latest California policy and politics news

Were forced to live in a situation where student workers are being priced out of neighborhood after neighborhood.

Landlords and some affordable housing advocates say Californians housing woes stem from an undersupply of housing, which they say Prop. 21 would exacerbate. And they point out that the state already passed a law this year to cap rent increases at about 8%.

Our true problem in California is the lack of affordable housing. Proposition 21 does nothing to address this issue and lacks a means test for acquiring a rent controlled unit, meaning even rich tenants will experience the benefits of rent control and, in fact, will be the first prospective tenants to gain access to the limited number of housing units at turnover, further making it harder for tenants of limited means to find housing, said Debra Carlton, vice president of state public affairs at the California Apartment Association.

But rent control can be effective at improving stability of neighborhoods and affordability for long term residents, said Mark Treskon, a senior research associate at the Urban Institute. Treskon said rent control is most effective as a suite of policies that include more housing for growing communities.

If Prop. 21 passes, Hill said, UAW 2865 members plan to organize locally to support the implementation of rent control in college neighborhoods. Both students and workers at California university campuses make up a really large percentage of the residents of those municipalities in which campuses are located, he said. So we are in a position to really move local law and organize to vote in politicians who represent our politics and who are willing to go to bat for us to fight for affordable housing.

Read more about Prop. 21 here.

Prop. 18 will allow 17-year-olds who will be 18 at the time of the general election to vote in the state primary and special elections. Eighteen states have similar measures in place, according to the National Conference of State Legislatures.

Supporters argue that this will allow young people to vote on important matters that directly affect them. Some studies have shown that people who vote from a young age are more likely to continue voting and that 17-year-olds score as well on civic knowledge as voters in their early 20s.

Young people are directly affected by issues like employment initiatives, affordable housing and education funding, state Assemblymember Kevin Mullin, the measures author, said in a press release. They have what I would call skin in the game on these and other issues and I believe we should be looking for ways to amplify their voices.

In opposition to the proposition, the Elections Integrity Project told the Legislature that 17-year-olds are legal minors. Under that definition, they are still considered children. They are almost all still living at home and under the strong influence of their parents. This is not conducive to independent thought and voting without undue pressure from their immediate superiors.

But young people dont blindly follow their parents beliefs, said Tyler Okeke, a youth advocate for Power California, which has supported measures to lower the voting age to 16 in the Bay Area and Los Angeles.

Were a generation that is very skeptical of what is being forced down our throats, he said. We all have to think for ourselves. And usually we go contrary to what were being told because we just have a record of being lied to.

Read more about Prop. 18 here.

Californias community colleges could see a windfall if Prop. 15 passes. Like Prop. 16, its a flashback to an earlier time in the states political historyin this case, 1978, when voters passed Proposition 13, which let landowners pay taxes based on a propertys original purchase price instead of its market value. Prop. 13 dramatically shrank the funding base for public schools and community colleges. Prop. 15 would expand that base again by assessing property tax based on market value for businesses that own California property worth more than $3 million. Homeowners will get to keep their tax breaks.

The tax change could generate up to $4.6 billion in new funding for K-12 schools and community colleges, the state Legislative Analysts Office estimates. (Local governments, which collect property taxes, would decide how to spend the rest of the funds.)

Improving educational attainment in California is not only a moral imperative, but also an economic one for both the students who stand to gain from quality, affordable higher educational opportunity as well as for the state as a whole, Debbie Cochrane, executive vice president for The Institute for College Access & Success, said in a statement. The passage of Proposition 15 would provide our states schools and community colleges with desperately needed support.

Opponents, including the California Chamber of Commerce, say that big commercial landlords targeted by the measure could pass costs on to their tenants. That could threaten small businesses and lead to price increases at stores and restaurants, they say.

Dont believe anyone who tells you that an $11.5 billion property tax increase wont cause economic harm, Edwin Lombard, president of the California Black Chamber of Commerce, wrote in a CalMatters opinion piece, particularly in a state facing more than 11.4% unemployment, with millions of businesses closed or a pay period away from closing.

Read more about Prop. 15 here.

Should California take on debt to continue funding stem cell research? The University of California regents think so and the university would be one of the biggest beneficiaries of Proposition 14 if it passes.

California has been running its own stem cell research agency since 2004, back when the federal government wouldnt fund certain experiments because of ethical concerns by pro-life advocates.

The California Institute for Regenerative Medicine provides grants for stem cell research, and runs internship programs in which high school and college students get hands-on training in the field. Higher education institutions have received a majority of the grant funds.

But in 2019, the agency announced that it was running out of money.

If Prop. 14 passes, the state would float $5.5 billion dollars in bonds to fund CIRM, guaranteeing it could continue to give grants, including $1.5 billion for the study of brain and neurological diseases. A bond is a loan that taxpayers have to pay back; last year, the state used around 3% of its general fund to repay bonds.

Besides UC, the Yes on 14 coalition includes patient advocacy organizations and other research institutes, who say the state would benefit from the clinical breakthroughs, jobs and royalty payments generated by CIRMs work.

But concerns have emerged about conflicts of interest on the board that awards the grants; even one of the boards own members, Jeff Sheehy, called Prop. 14 a scam. The board has members appointed by some of the same universities and pharmaceutical companies that have received the biggest chunks of funding. In 2013, the Institute of Medicine released a report recommending that CIRM change its governance structure to appoint more independent members, and to not guarantee membership to organizations. Prop. 14 does not address those recommendations.

Read more about Prop. 14 here.

Ethan Edward Coston is a former fellow with the CalMatters College Journalism Network, a collaboration between CalMatters and student journalists from across California. This story and other higher education coverage are supported by the College Futures Foundation.

As a nonprofit newsroom, we rely on the generosity of Californians like you to cover the issues that matter. If you value our reporting, support our journalism with a donation.

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Five ballot propositions that would affect students - CALmatters