Category Archives: Stell Cell Research


Investments in Innovation to Drive the Animal stem cell therapy Market between 2017 and 2025 – Industry Today

Animal stem cell therapy is a usage of animals stem cell to treat a disease or disorder. The ability of stem cell is to divide and differentiate into a cell with specialized function useful for repairing body tissues damaged by injury or disease.

Animal stem cell therapy is a usage of animals stem cell to treat a disease or disorder. The ability of stem cell is to divide and differentiate into a cell with specialized function useful for repairing body tissues damaged by injury or disease. The animal stem cell therapy process involve three steps which include collection of stem cell sample from animals and preparing the sample to concentrate the stem cells. Finally, the therapy includes transferring the stem cells into the injured site for treatment. Animal stem cell therapy increases the expectancy of life in animals with no side effects. It is available for the treatment of arthritis, degenerative joint disorders, tendon, and ligaments injuries in animals. Stem cell therapy is most often used to treat dogs, cats, and horses. But recent developments made it possible to use animal stem cell therapy in tiger, pig, etc. Present animal stem cell therapy is studied in treatments of the inflammatory bowel, kidney, liver, heart and immune-mediated diseases respectively.

Animal Stem Cell Therapy Market: Drivers and Restraints

Increasing prevalence of disease in animals with growing population and to increase the animals quality of life, the companies focus shifting towards animal stem cell therapies. Along with increasing government funding for the protection of animals and fast approvals of FDA contributing towards the rapid growth of the animal stem cell therapy. The research in animal stem cells offers great promise for understanding underlying mechanisms of animal development; it gives great opportunities to treat a broad range of diseases and conditions in animals. Animal stem cell therapy is increasingly recognized as critical translational models of human disease for treatment. All these factors act as drivers for the robust growth of the animal stem cell therapy market.

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Animal Stem Cell Therapy Market: Segmentation

Segmentation based on Applications

Segmentation based on End-user

Animal Stem Cell Therapy Market: Market Overview

Studies in the animal stem cell therapy continue at a breathtaking pace due to increasing demand and treatment cost covered in reimbursements. And animal stem cell therapy is more effective than traditional treatment available in the market which is boosting the companies to increase the spending in the R&D for innovative methods. Because of the novelty and complexity of animal stem cell therapy, FDA encourages individuals, universities and drug companies for further innovations. The future expected with double CAGR during the forecasted period.

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Animal Stem Cell Therapy Market: Region-wise Overview

Regarding geographies, North America is dominating the global animal stem cell therapy market due to the increased incidence rate and awareness about the therapy. U.S represents the largest market share in the North America due to the increasing demand for the therapy. Europe and Asia-Pacific are showing a significant growth rate during the forecasted period due to the growing adoption of the animal stem cell therapy. The animal stem cell therapy market in underdeveloped countries is slow when compared to the developed countries.

Animal Stem Cell Therapy Market: Key Participants

The key participants in the animal stem cell therapy market are Magellan Stem Cells, ANIMAL CELL THERAPIES, Abbott Animal Hospital, VETSTEM BIOPHARMA, Veterinary Hospital and Clinic Frisco, CO, etc. The companies are entering into the collaboration and partnership to keep up the pace of the innovations.

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Investments in Innovation to Drive the Animal stem cell therapy Market between 2017 and 2025 - Industry Today

Fred Hutch Evergreen Fund awards six grants to promising projects – Fred Hutch News Service

Six Fred Hutchinson Cancer Research Center teams have been selected as this years recipients of grants from the Evergreen Fund, which supports early research projects thought to have enough commercial potential to attract future business partners.

Since 2017, the donor-supported Evergreen Fund has awarded over $4 million to projects proposed by scientists seeking a well-timed financial boost to translate their ideas into lifesaving advances for patients.

Despite the disruption of COVID-19, the Evergreen Fund once again offers our researchers the opportunity to complete the critical experiments that venture capital and pharma partners expect to see when evaluating a partnership opportunity, said Hilary Hehman, the Hutchs associate vice president of Strategic Partnerships & Alliances.

The Hutch program also provides researchers feedback on their research, funded or not, from a group of seasoned investors who evaluated their proposals.

This year, the Evergreen Fund distributed three pilot grants of $50,000 each that are designed to give big and bold ideas with commercial application an infusion of funds to demonstrate the projects potential within a six-month period. Another trio of projects were awarded $200,000 each to accelerate their research over a two-year period. The goal of these larger, so-called Beyond Pilot grants is to help researchers whose ideas are further along. These scientists have shown promising data and a commercial path forward, but their projects need more development to attract external financial support.

Drs. Kristin Anderson and Lucas Sullivan received a Beyond Pilot grant for their project to boost the viability of T cells engineered to destroy pancreatic tumors, malignancies stubbornly resistant to therapies. Andersons T cells, designed with receptors that zero in on specific molecular markers on the pancreatic tumor cell surface, have shown promise in preclinical studies.

Yet these living drugs cannot survive for long in the toxic microenvironment of pancreatic tumors. The team is experimenting with new approach they call metabolic reprogramming, which involves a second bit of T-cell engineering. It equips the T cells with an enzyme that allows them to make their own supply of aspartate, a critical amino acid they are starved of inside these tumors.

Both tumor and healthy cells alike need aspartate, but within these toxic tumors, T cells are outcompeted by cancer cells for the raw material both need to make it. By engineering an aspartate-making enzyme into their T cells, the researchers hope to give them the extra oomph needed to survive. If they stay alive, these T cells may have a fighting chance against a cancer known to researchers as the beast of all beasts.

Drs.Irv Bernsteinand Suzanne Furuyama are studying whether they can reverse the ability of solid tumors to evade immunotherapy. Their focus is on the tumor microenvironment, where a tug-of-war is underway for control of the bodys immune response. Key to winning is to turn on an intercellular signaling system called Notch, which shifts the balance of immune cells from a tumor-protective to an anti-tumor state.

But simply flipping the Notch switch on can set inflammation loose against healthy cells as well. Bernsteins team has engineered a switch-flipper that recognizes both tumor cells and Notch to ramp up the inflammatory response of immune cells only in the right places. Their project will involve studies in mice to determine if the Notch-induced, anti-tumor immune cell state enhances solid tumor susceptibility to immunotherapies.

Drs. Justin Taylor and Jim Boonyaratanakornkit are developing a laboratory-designed antibody, a type of immune protein, capable of blocking four different respiratory viruses. Each of these common viruses poses a significant threat to the lives of cancer patients recovering from blood stem cell transplants. The four targeted viruses respiratory syncytial virus, human metapneumovirus, and two common strains of human parainfluenzavirus are among the deadliest for these patients and afflict vulnerable children and the elderly as well. Previously, the Taylor Lab has been able to isolate antibodies capable of protecting against at least two such viruses at the same time. The aim of this project is to engineer and test in animal models an antibody that can neutralize all four targeted viruses, leading to a new type of drug capable of saving thousands of lives each year.

Drs. Jarrod Dudakov and Sinad Kinsella study age-related decline of the thymus, the gland responsible for generating the diverse selection of T-cell receptors needed for a successful response to vaccines or pathogens. In their search for ways to stimulate regeneration of the thymus, they have identified two proteins, known as FOXN1 and DLL4, that are critical to regenerating thymus cells. The goal of their pilot project is to create a screening test for molecules that drive production of either of those proteins. Such protein-inducing molecules might serve as the basis for new clinical approaches that boost T- cell reconstitution. They could help restore immune function in transplant recipients as well as in patients whose thymus glands have been decimated by age, infection or chemotherapies.

Dr. Stephen Tapscott has joined with Dr. Robert Bradley, holder of the McIlwain Family Endowed Chair in Data Science, on a pilot project to explore the therapeutic potential of their discoveries of one way tumors may evade destruction by our immune system. Their focus is on a protein called DUX4, which may be used by a developing embryo and fetus to shield its cells from a mothers immune system. Shut down during childhood, the DUX4 gene is reawakened by some tumor cells, which use the ensuing shower of DUX4 proteins as an invisibility cloak against assault by cancer-attacking T cells. The researchers will develop an inventory of tumor cells that ramp up production of DUX4, explore what mutations enable this reawakening and establish strategies to disrupt it.

Drs. Ming Yu and William Grady are developing a highly sensitive test for early detection of both a deadly form of esophageal cancer and a precursor condition of abnormal cell growth known as high grade dysplasia, or HGD. Their testing panel, which picks up three distinctive genetic markers in patient specimens, has been shown to detect either HGD or the cancer esophageal adenocarcinoma in samples from biopsies or endoscopies. However, those procedures are invasive and expensive.

The pilot project aims to validate their test panel for use in a low-cost device that probes the esophagus with a pill-sized balloon rather than an endoscope. A less-expensive early detection test is expected to reduce mortality from esophageal adenocarcinoma, which is diagnosed in nearly 20,000 Americans each year.

Note:Scientists at Fred Hutch played a role in developing these discoveries, and Fred Hutch and certain of its scientists may benefit financially from this work in the future

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Fred Hutch Evergreen Fund awards six grants to promising projects - Fred Hutch News Service

Asymmetrex Receives $0.42 Million Award from the NIH-National Heart Lung and Blood Institute to Develop the AlphaSTEM Test for Stem Cell Therapies and…

Asymmetrex Receives $0.42 Million R&D Award from NIH-NHLBI

BOSTON (PRWEB) September 22, 2020

On the heals of Asymmetrexs recently published peer-reviewed report describing its development of a method for quantifying therapeutic tissue stem cells, on Saturday September 19, the company received a Notice of Award of its first Phase I Small Business Innovation Research (SBIR) grant from the U.S. National Institutes of Health. Sponsored by the National Heart Lung and Blood Institute, the $0.42 million 1 year award recognizes the potential major impact of Asymmetrexs first-in-kind technology in the stem cell medicine and drug development industries.

Asymmetrex founder and director James L. Sherley, M.D., Ph.D. spent most of Saturday contacting collaborators, contract service providers involved in the project, corporate partners, and industry colleagues who endorsed the grant application to share the news of the award. I couldnt wait until Monday to share this news. No one does biotechnology development and commercialization successfully alone; and Asymmetrex is fortunate to have the kind of support that gets a company to important milestones like this one.

The new funds will accelerate the technical and business development of two applications of the companys AlphaSTEM Test tissue stem cell counting technology. One goal is to evaluate in a head-to-head comparison how the companys computational counting technology relates to the only existing method for specific estimation of the dosage of a therapeutic tissue stem cell.

Human blood stem cells can be estimated specifically by transplanting cells into mice. This test method is expensive, slow (taking 12-16 weeks), and variable. Asymmetrex already established reported in the recent publication that its technology compares well to the published literature for the mouse test, but has significantly less variability. The direct comparison will increase industry confidence and pave the way to raising more financing for advancing the AlphaSTEM Test to clinical evaluations. The companys first clinical application target is determining the dose of stem cells in umbilical cord blood to identify which units will be lifesaving for children after leukemia treatment. In current clinical practice, 15-18% of children receive an ineffective transplant, because the stem cell dose was not known.

The second major milestone accomplished with award funding will be measurement of how well the AlphaSTEM Test identifies drug candidates that are toxic to tissue stem cells, like those in the liver and bone marrow. Drugs that are toxic to tissue stem cells cause chronic organ failure, a life-threatening event for clinical trial patients and a financial catastrophe for a drug development program. Such failures in Phase II and Phase III clinical trials cost the U.S. pharmaceutical industry $4-5 billion in losses each year. Currently, besides these late costly failures, the only way to identify tissue stem cell-toxic drug candidates is with expensive animal toxicology evaluations. Animal evaluations are notorious for their poor ability to predict human toxicities.

The companys seminal report contains preliminary evidence of the AlphaSTEM Tests ability to identify either tissue stem cell-toxic or tissue stem cell-activating compounds inexpensively in cell culture. The latter ability has application for discovery of new compounds that accelerate wound healing and combat effects of aging, including cosmetics. With the new award, Asymmetrex will extend the preliminary studies to the full-scale analyses needed by pharmaceutical companies for their evaluations.

About Asymmetrex

Asymmetrex, LLC is a Massachusetts life sciences company with a focus on developing technologies to advance stem cell medicine. The companys U.S. and U.K. patent portfolio contains biotechnologies that solve the two main technical problems production and quantification that have stood in the way of effective use of human adult tissue stem cells for regenerative medicine and drug development. Asymmetrex markets the first technology for determination of the dose and quality of tissue stem cell preparations (the AlphaSTEM Test) for use in stem cell transplantation therapies and pre-clinical drug evaluations. Asymmetrex is a member company of the Advanced Regenerative Manufacturing Institute BioFabUSA and the Massachusetts Biotechnology Council.

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Asymmetrex Receives $0.42 Million Award from the NIH-National Heart Lung and Blood Institute to Develop the AlphaSTEM Test for Stem Cell Therapies and...

City of Hope Enters Licensing Agreement With Chimeric to Develop Its Pioneering Chlorotoxin CAR T Cell Therapy | DNA RNA and Cells | News Channels -…

Details Category: DNA RNA and Cells Published on Tuesday, 22 September 2020 10:38 Hits: 317

The comprehensive cancer center has also dosed its first patient in chlorotoxin CAR T cell therapy trial

DUARTE, CA, USA I September 21, 2020 I City of Hope, a world-renowned independent research and treatment center for cancer, diabetes and other life-threatening diseases, today announced that it has licensed intellectual property relating to its pioneering chlorotoxin chimeric antigen receptor (CLTX-CAR) T cell therapy to Chimeric Therapeutics Limited, an Australian biotechnology company.

The therapy is currently being used in a phase 1 clinical trial at City of Hope to treat glioblastoma (GBM), a type of brain tumor. The first patient in the trial was recently dosed; Behnam Badie, M.D., chief of City of Hopes Division of Neurosurgery and The Heritage Provider Network Professor in Gene Therapy, is leading this innovative, first-of-its-kind trial.

Chimeric has acquired the exclusive worldwide rights to develop and commercialize certain patents relating to City of Hopes CLTX-CAR T cells, as well as to further develop the therapy for other cancers.

City of Hope is excited to enter into this agreement with Chimeric as it supports our innovative research in CAR T cell therapy and our commitment to extend these therapies to more patients, particularly those with GBM and other solid tumors that are difficult to treat, said Christine Brown, Ph.D., The Heritage Provider Network Professor in Immunotherapy and deputy director of City of Hopes T Cell Therapeutics Research Laboratory. Chimeric shares our goal of providing effective CAR T cell therapies to more patients with current unmet medical needs.

Led by Brown and Michael Barish, Ph.D., chair of City of Hopes Department of Developmental and Stem Cell Biology, and Dongrui Wang, Ph.D., a recent graduate of City of Hopes Irell & Manella Graduate School of Biological Sciences, the team developed and tested the first CAR T cell therapy using CLTX, a component of scorpion venom, to direct T cells to target brain tumor cells. The research was published this past March in Science Translational Medicine.

Chimeric is excited to join City of Hope in its quest to find more effective cancer therapies. This is an exceedingly rare opportunity to acquire a promising technology in one of the most exciting areas of immuno-oncology today, said Paul Hopper, executive chairman of Chimeric. Furthermore, the CLTX-CAR T cell therapy has completed years of preclinical research and development, and recently enrolled its first patient in a phase 1 clinical trial for brain cancer.

CARs commonly incorporate a monoclonal antibody sequence in their targeting domain, enabling CAR T cells to recognize antigens and kill tumor cells. In contrast, the CLTX-CAR uses a synthetic 36-amino acid peptide sequence first isolated from death stalker scorpion venom and now engineered to serve as the CAR recognition domain.

In this recent study, City of Hope researchers used tumor cells in resection samples from a cohort of patients with GBM to compare CLTX binding with expression of antigens currently under investigation as CAR T cell targets. They found that CLTX bound to a greater proportion of patient tumors, and cells within these tumors.

CLTX binding included the GBM stem-like cells thought to seed tumor recurrence. Consistent with these observations, CLTX-CAR T cells recognized and killed broad populations of GBM cells while ignoring nontumor cells in the brain and other organs. The study team demonstrated that CLTX-directed CAR T cells are highly effective at selectively killing human GBM cells without off-tumor targeting and toxicity in cell-based assays and in animal models.

City of Hope, a recognized leader in CAR T cell therapies for GBM and other cancers, has treated more than 500 patients since its CAR T program started in the late 1990s. The institution continues to have one of the most comprehensive CAR T cell clinical research programs in the world it currently has 30 ongoing CAR T cell clinical trials, including CAR T cell trials for HER-2 positive breast cancer that has spread to the brain, and PSCA-positive bone metastatic prostate cancer. It was the first and only cancer center to treat GBM patients with CAR T cells targeting IL13R2, and the first to administer CAR T cell therapy locally in the brain, either by direct injection at the tumor site, through intraventricular infusion into the cerebrospinal fluid, or both. In late 2019, City of Hope opened a first-in-human clinical trial for patients with recurrent GBM, combining IL13R2-CAR T cells with checkpoint inhibitors nivolumab, an anti-PD1 antibody, and ipilimumab, blocking the CTLA-4 protein.

Both an academic medical center and a drug development powerhouse, City of Hope is known for creating the technology used in the development of human synthetic insulin and numerous breakthrough cancer drugs. Its unique research and development hybrid of the academic and commercial creates an infrastructure that enables City of Hope researchers to submit an average of 50 investigational new drug applications to the U.S. Food and Drug Administration each year. The institution currently holds more than 450 patent families.

"City of Hope is delighted to license this technology to Chimeric, said Sangeeta Bardhan Cook, Ph.D., City of Hope director of the Office of Technology Licensing. We are impressed with the ability of their executive team to push and bring therapies to market expeditiously. At City of Hope, our mission is to transform the future of health care. We believe Chimeric has the vision to offer innovative therapies to cancer patients.

About City of Hope

City of Hope is an independent biomedical research and treatment center for cancer, diabetes and other life-threatening diseases. Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hopes translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin and numerous breakthrough cancer drugs are based on technology developed at the institution. A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope has been ranked among the nations Best Hospitals in cancer by U.S. News & World Report for 14 consecutive years. Its main campus is located near Los Angeles, with additional locations throughout Southern California. For more information about City of Hope, follow us on Facebook, Twitter, YouTube or Instagram.

SOURCE: City of Hope

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City of Hope Enters Licensing Agreement With Chimeric to Develop Its Pioneering Chlorotoxin CAR T Cell Therapy | DNA RNA and Cells | News Channels -...

Voting while God is watching does having churches as polling stations sway the ballot? – Huron Daily Tribune

Eds: This story was supplied by The Conversation for AP customers. The Associated Press does not guarantee the content.

Jordan LaBouff, University of Maine

(THE CONVERSATION) Houses of worship may be busier than usual come Election Day as Americans head to the polls rather than the pews.

A 2010 census of religious congregations identified nearly 350,000 churches, mosques, temples and other religious establishments attended by more than 150 million Americans, primarily for spiritual needs and social relationships.

But during elections, such places double as centers of civic life serving as community polling places. In some electoral districts, houses of worship make up a significant number of all voting places, raising important issues about whether voting in a place of worship influences how people cast their ballots.

Church and state

Voting in religious spaces is nothing new.

Americans have long been casting their ballots in the same place where they or their neighbors worship. In early America, the town meeting house often served both religious and secular functions with the same space housing prayer meetings, schooling and town business.

Although the separation of church and state has largely moved the practice of religious and secular life into separate spheres, churches have continued to house voting booths.

As urban population densities have grown more than 500% from 1910 to 2010 election boards have been asked to identify polling sites that are large and empty enough to accommodate voters. They also need to be accessible and rent-free. Since government buildings can rarely accommodate these needs indeed, less than 1% of polling sites in 2018 were specifically election offices religious leaders have often offered their buildings as polling sites as a public service.

Although no national data on religious spaces as polling places exists, this arrangement appears to be very common.

For example, 22% of polling sites for the 2020 general election in Minneapolis are houses of worship. In St. Louis, 27% of precincts vote in religious spaces and, in one ward, all eight of the polling places are churches.

Priming voters

As a scholar who studies how social situations can influence attitudes, I believe where someone votes can subtly but significantly affect how they vote.

Social scientists have long understood that physical and social context shapes the way people think, feel and behave. Without even realizing it, most of us are likely to speak more quietly when talking about the possibility of visiting a library than when discussing plans to dine at an exclusive restaurant.

Each physical setting offers cues that, at least temporarily, prompt people to think and behave in ways consistent with stereotypes about that space. Scholars call this a priming effect.

Sometimes this happens consciously as people realize that they are influenced by the situation. For example, you might feel serious and reverent while visiting a war memorial. Much of the time, however, people arent aware of the subtle priming influences of everyday spaces.

These unconscious influences can be powerful.

For example, people in a business-themed room with briefcases and boardroom tables tended to act more competitive and self-interested in decisions than those making the same decisions in a classroom, researchers found.

Similarly, on average, people who could see a sports drink rather than a bottle of water ran longer on a treadmill. And those hearing French music over supermarket loudspeakers were more likely to buy French wine than when German music was playing.

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Ballot bias

These effects extend to the polling booth.

In Arizonas 2000 general election, citizens voting in schools were more likely to support a state sales tax increase to fund education than citizens with similar social and political characteristics who cast ballots elsewhere.

In a related laboratory study, voters shown images of a school encouraged support for education-oriented taxation, whereas images of a church reduced support for stem-cell research.

In 2012, my colleagues and I asked approximately 100 participants from more than 20 different countries to answer questions about their political attitudes and feelings toward various minority groups while standing in front of a cathedral or City Hall in Maastricht, the Netherlands.

Regardless of their own religious identity or beliefs, respondents who could see the church supported more conservative approaches to issues such as immigration, taxes, drug policies, warfare and abortion than those who could see City Hall. They were also more prejudiced toward minorities such as gay men and immigrants especially those of Arab descent.

Our recent analysis of 2016 election data from Virginia reveals similar tendencies. Controlling for population, county-level religiosity and other factors, citizens casting their ballots in churches were significantly more likely to vote for Republican candidates than their nearly identical neighbors who were voting in secular venues.

This effect was strongest for counties with the highest proportion of religious people. That is, when Christians vote in churches, they seem to be even more likely to vote for conservative candidates than when they vote outside of churches.

Further, which houses of worship are selected may invite more bias into the polling booth. When a single mosque was included as a polling site among more than 50 churches in Palm Beach County, Florida, in 2016, the countys election board received complaints and threats of violence until they removed the mosque as a polling site.

Meanwhile, Christian churches are common polling sites even in communities that are not themselves predominantly Christian.

As a result, some citizens who may feel stigmatized and threatened by religious institutions are expected to visit them to vote.

Small influence but tight margins

Although some non-Christian citizens have complained that voting in churches violates their rights, courts have consistently ruled that the availability of alternatives such as absentee voting means that having places of religion serve as polling stations does not represent a violation of the First Amendment of the Constitution, which guarantees the freedom of religion.

In other words, where you are can influence who you are, even when you dont notice it. Although the influences of physical spaces are small and people are more likely to be influenced by these kinds of peripheral cues when they dont already have strong opinions on a topic, elections can be decided by fractions of a percent especially in consequential local races where people may enter the polling booth undecided, and thus be more susceptible to the influences of the space theyre in.

The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts. The Conversation is wholly responsible for the content.

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Voting while God is watching does having churches as polling stations sway the ballot? - Huron Daily Tribune

Synthetic Stem Cells Market Research: Aim To Achieve The Pinnacle In Qualitative Industry Research And Business Intelligence – The Daily Chronicle

The report titled Synthetic Stem Cells Marketoffers a primary impression of the Synthetic Stem Cells industry covering different productScope, Characterizations, Classifications, Objectives, and Participantsin the industry chain structure. Synthetic Stem Cells Market (6 Forces Forecast 2020-2026) research report offers in-intensity insight of the Synthetic Stem Cells industry masking all vital parameters along with Marketing Channel, Direct Marketing, Indirect Marketing,Brand Strategy, Pricing Strategy,Market Positioning, Target Client, and Distributors/Traders List.

Synthetic Stem Cells market report profiles major topmost manufactures operating (North Carolina State University, Zhengzhou University) in terms of analyses various attributes such asCompany Profile, Product Specifications, Revenue, Gross, Gross Margin, Cost, Capacity, CAGR, Production Valueand contact information.

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Synopsis of Synthetic Stem Cells Market:Synthetic stem cells offer therapeutic benefits comparable to those from natural stem cells and could reduce some of the risks associated with stem cell therapies. Additionally, these cells have better preservation stability and the technology is generalizable to other types of stem cells.

On the basis of product, this report displays the sales volume, revenue (Million USD), product price, market share and growth rate of each type, primarily split into-

Cardiovascular Diseases Neurological Disorders Other Diseases

On the basis on the end users/applications, this report focuses on the status and outlook for major applications/end users, sales volume, market share and growth rate of Synthetic Stem Cells market for each application, including-

Cancers Wounds and Injuries Musculoskeletal Disorders Blood disorders

Synthetic Stem Cells Market: Regional Analysis Includes:

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What are some of the most prominent Synthetic Stem Cells market currently in development? What are their activities, platform technology and recent developments?

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Synthetic Stem Cells Market Research: Aim To Achieve The Pinnacle In Qualitative Industry Research And Business Intelligence - The Daily Chronicle

Cell Line Development Market Report Analysis with Industry Share Insights Shared in Detailed Report – The Daily Chronicle

Cell line development is an important technology in life sciences. Stable cell lines are used for various applications including monoclonal antibody and recombinant protein productions, gene functional studies, and drug screening. Manual screening method is a traditional method used for cell line development. This method is tend to be disadvantageous as it is labor-intensive and time-consuming. Automation in tools used for cell line development is likely to replace manual methods of cell line development.

Cell line development and culturing is being rapidly adopted in areas of biological drug developments for various chronic diseases, regenerative medicines such as stem cells & cell-based therapies, recombinant protein, and other cellular entities for pharmaceuticals, diagnostics, and various other industries

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Global Cell Line Development Market Witness Most Promising Rise in Demand:

Rise in focus on research & development, owing to increase in prevalence of cancer and other chronic diseases is anticipated to drive the market. Several institutes, such as Cancer Research Institute, National Cancer Institute, Advanced Centre for Treatment, Research and Education in Cancer (Cancer Research Centre [ICRC]), and NCI Community Oncology Research Program (NCORP), are engaged in research & development for cancer diagnosis and treatment. Hence, the initiative of government and non-government organizations is likely boost the growth of the market.

Advances in bioinformatics and recombinant technologies have led to development of new cell lines for synthesis or production of essential peptides, enzymes, saccharides, and other molecules which are being used in pharmaceuticals and various other industries.

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The global cell line development market is highly concentrated due to the presence of key players. A large number of manufacturers hold major share in their respective regions. Key players engaged in adopting new strategies are likely to drive the global cell line development market. Key players are developing new, cost-effective biologic products. This is anticipated to augment the market.

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This report profiles major players in the global Cell Line Development market based on various attributes such as company overview, financial overview, product portfolio, business strategies, and recent developments

Merck KGaA, Selexis SA, Lonza, ATCC, Solentim Ltd. Sphere Fluidics Limited, WuXi Biologics, Thermo Fisher Scientific, GE Healthcare, Aragen Bioscience Contract Manufacturer, Sartorius AG

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Genprex Names Seasoned IP Executive, Thomas C. Gallagher, as Senior Vice President of Intellectual Property and Licensing – Business Wire

AUSTIN, Texas--(BUSINESS WIRE)--Genprex, Inc. (Genprex or the Company) (NASDAQ: GNPX), a clinical-stage gene therapy company developing potentially life-changing technologies for patients with cancer and diabetes, today announced it has named Thomas C. Gallagher, Esq. as the Companys Senior Vice President of Intellectual Property and Licensing. Mr. Gallagher has extensive experience in the area of biotechnology intellectual property (IP) law, business development, and licensing transactions with industry and academic institutions.

Mr. Gallagher will play a critical role in advancing our expanding intellectual property estate by spearheading IP strategy, which is an important element of the Companys overall success and value creation. A seasoned biotech executive, he will provide significant support as we execute on broadening our research and development programs, explore opportunities for partnerships on our existing programs, and opportunistically acquire new technologies to further expand our pipeline, said Rodney Varner, President and Chief Executive Officer of Genprex.

Mr. Gallagher has more than 20 years of experience as an intellectual property attorney. Prior to joining Genprex, he served as Principal at the Fenagh Group, an IP and licensing consultancy providing clients in the healthcare sector guidance on all aspects of patent and trademark portfolio management, intellectual property due diligence, freedom-to-operate analysis and related transactional work. He has also served as Senior Vice President of Intellectual Property and Licensing at Kadmon Corporation, LLC, a biopharmaceutical company based in Manhattan. Prior to joining Kadmon, he served as in-house IP counsel at Neostem Inc. (now Caladrius Biosciences, Inc.), a company focused on stem cell biology. Previously, he held several positions at ImClone Systems Incorporated, most recently as Vice President of Intellectual Property and Licensing. While at ImClone, he was responsible for all aspects of intellectual property and led the IP function in multiple due diligence undertakings by major pharmaceutical companies, which resulted in a $2 billion strategic investment, the highest-valued biotech deal ever at the time, and the eventual sale of the company to Eli Lilly and Company for $6.5 billion.

Mr. Gallagher is experienced in both patent prosecution and litigation, as well as intellectual property issues relating to business development and licensing matters. His patent litigation experience includes European litigation and opposition proceedings. In addition to a law degree, Mr. Gallagher holds a Masters degree in molecular biology. Before becoming an attorney, Mr. Gallagher worked as a molecular biologist in France, Spain and the United States.

About Genprex, Inc.

Genprex, Inc. is a clinical-stage gene therapy company developing potentially life-changing technologies for patients with cancer and diabetes. Genprexs technologies are designed to administer disease-fighting genes to provide new treatment options for large patient populations with cancer and diabetes who currently have limited treatment options. Genprex works with world-class institutions and collaborators to develop drug candidates to further its pipeline of gene therapies in order to provide novel treatment approaches. The Companys lead product candidate, GPX-001 (quaratusugene ozeplasmid), is being evaluated as a treatment for non-small cell lung cancer (NSCLC). GPX-001 has a multimodal mechanism of action that has been shown to interrupt cell signaling pathways that cause replication and proliferation of cancer cells; re-establish pathways for apoptosis, or programmed cell death, in cancer cells; and modulate the immune response against cancer cells. GPX-001 has also been shown to block mechanisms that create drug resistance. In January 2020, the U.S. Food and Drug Administration granted Fast Track Designation for GPX-001 for NSCLC in combination therapy with osimertinib (AstraZenecas Tagrisso) for patients with EFGR mutations whose tumors progressed after treatment with osimertinib alone. For more information, please visit the Companys web site at http://www.genprex.com or follow Genprex on Twitter, Facebook and LinkedIn.

Forward-Looking Statements

Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements regarding the effect of Genprexs product candidates, alone and in combination with other therapies, on cancer and diabetes, regarding potential, current and planned clinical trials, regarding the Companys future growth and financial status and regarding our commercial partnerships and intellectual property licenses. Risks that contribute to the uncertain nature of the forward-looking statements include the presence and level of the effect of our product candidates, alone and in combination with other therapies, on cancer; the timing and success of our clinical trials and planned clinical trials of GPX-001, alone and in combination with targeted therapies and/or immunotherapies, and whether our other potential product candidates, including GPX-002, our gene therapy in diabetes, advance into clinical trials; the success of our strategic partnerships, including those relating to manufacturing of our product candidates; the timing and success at all of obtaining FDA approval of GPX-001 and our other potential product candidates including whether we receive fast track or similar regulatory designations; costs associated with developing our product candidates, whether we identify and succeed in acquiring other technologies and whether patents will ever be issued under patent applications that are the subject of our license agreements or otherwise. These and other risks and uncertainties are described more fully under the caption Risk Factors and elsewhere in our filings and reports with the United States Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. We undertake no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.

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Genprex Names Seasoned IP Executive, Thomas C. Gallagher, as Senior Vice President of Intellectual Property and Licensing - Business Wire

Global Vaccine, Insulin and Stem Cell Market Research Report Profitable Segments, Current and Future Industry Analysis till 2026 – The Daily Chronicle

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Global Vaccine, Insulin and Stem Cell Market Research Report Profitable Segments, Current and Future Industry Analysis till 2026 - The Daily Chronicle

Changing STEM Representation Trends Through the Philadelphia AMP Alliance – DrexelNow – Drexel Now

Jazmean Williams, a 2020 graduate with a BS in biomedical engineering, in the lab during her six-month research co-op in Wellington, New Zealand funded partially by Drexel-LSAMP.

When Stephen Cox started as an undergraduate student at Drexel University (then called the Drexel Institute of Technology) in 1969, it was sparsely populated with minority students like him, he says.

Then, after receiving his BS in physics and atmospheric science in 1974 and his MS in biophysics and biomedical engineering (both from Drexel) in 1976, Cox left Drexel and jumped into an industry career with positions at General Electric and Boeing. There, he saw a similar trend very few people of color were operating alongside him in these scientific positions and venues.

So in the early 90s, Cox started working to reverse this trend, and he had help. The National Science Foundation (NSF) wanted to establish multi-year, multi-million-dollar grants to support institutions and programming proven to increase the number of underrepresented students moving into STEM-related paths of study and, ultimately, careers.

In 1994, this funding and Coxs work helped found the Greater Philadelphia Region Alliance for Minority Participation (Philadelphia AMP), which is part of the national, NSF-founded Louis Stokes Alliances for Minority Participation (LSAMP) program. Philadelphia AMP brought together nine higher-education institutions to work and share resources toward a common goal to double the number of minority students receiving degrees in STEM disciplines over the next five years as this NSF-funded alliance model had already proven successful in doing so in additional areas of the country.

Stephen Cox (BS '74 MS '76) is co-principal investigator and project director of Philadelphia AMP.

And in that five-year time frame, Philadelphia AMP had more than achieved the goal, and Cox had also been invited to headquarter the alliance at his alma mater. He is now co-principal investigator and project director of Philadelphia AMP, leading the alliance alongside Nina Henderson Provost Paul Jensen, PhD, and Aroutis Foster, PhD, an associate dean of Drexels School of Education.

Because I knew of the impact of cooperative education, I thought that Drexel would be a good site to create the leadership of the initiative, he said.

Now, the 27-year-old Philadelphia AMP Alliance continues to thrive at host institution Drexel and across partner institutions, including the University of Pennsylvania, Temple University, Community College of Philadelphia, Cheyney University of Pennsylvania, Lincoln University, the University of Delaware, Delaware State University and Rowan University. The LSAMP model has also taken hold in all areas of the country, from Puerto Rico to Hawaii.

Each university in the Philadelphia Alliance supports its own programming, activities, research opportunities, academic coaching, mentorship and funding, and the institutions also support each other, all in an effort to sustain what is now the annual graduation of well over 1,000 minority students into STEM graduate and PhD programs or careers. This is compared to the just 200 graduating with STEM degrees back before the alliance began.

As an alliance, we've been very successful in capturing the funding, but also providing the opportunities for students to succeed, who prior to this were not really looked at as a necessary outcome, Cox said. You know, it's easy to talk about being diverse, but the reality of diversity is how you produce a product and we've been able to do that successfully over a 26-year period, so much so that this year NSF has awarded us again a $3.2 million grant to continue this work from now through 2025.

The continued work of Philadelphia AMP is both important and complex, and critical in current turbulent times, Cox said.

We see right now, the country is in turmoil. Issues of race and ethnicity and gender are all things that are still issues 25, 30 years later, he added. That has not gone away in America.

But despite all this complexity, how Drexel students get involved with LSAMP on an individual level is often quite simple.

For Jazmean Williams, a 2020 graduate with a BS in biomedical engineering, it started with a friend encouraging her to come to an LSAMP meeting while she was on campus summer term of her first year participating in the STAR Scholars program.

Just hearing what some of the current students in the program were doing and how LSAMP had basically bolstered their research rsum and the different outreach programs that they were able to do, that just made me so excited, Williams remembered. So I was like, OK, I'm going to join and I'm going to be involved, and I've been involved ever since.

From that moment on, LSAMP became a very big part of Williams Drexel experience. Without it, she said many of the research opportunities she was able to do in undergrad wouldnt have been possible, including the six-month research co-op in New Zealand she completed last year, and through which she solidified her goal of doing stem cell research as a career.

Jazmean Williams enjoying some down time while on an LSAMP-funded research co-op in New Zealand.

Without LSAMP, I would have never been able to leave the ground, Williams said. [The program] was able to help pay for my plane ticket and also provided resources for finding housing.

Because of that experience, I feel like it made my rsum a lot more attractive. Its a great talking point, too. I'm able to just talk about the experience of living in a new country on my own and being involved within a new culture, she continued. It shows not only your flexibility, but your ability to adapt and ability to problem solve. So, yeah, it was just an awesome experience.

For Julian Rath and Salamata Bah, it started with an email from Drexel-LSAMP Director Marisol Rodriguez Mergenthal, which arrived in their inbox at the right time, offering the right opportunity. Rath was having trouble back in March securing his first co-op opportunity due to complications caused by the pandemic. Then he found out that through LSAMP, he could take an online scientific computing course taught by scientists of the Brookhaven National Laboratory that was bound to help give him a leg up in his area of career interest, nuclear science. Better yet, he could get paid to take the course.

There were literally no aspects of the opportunity that I could have ever considered turning down, Rath, a pre-junior majoring in chemistry, said. With the career that I'm planning on going into, I need as much experience and credibility as I can get. Taking a class with Brookhaven National Laboratory on how to actually use the programs utilized in the field should help me greatly in the future.

Funded by a part-time stipend from LSAMP, Rath went on to complete a co-op position with the Peace Innovation Institute arranged by Joseph Hughes, PhD, and other College of Engineering faculty.

Bah, now a second-year computer science major, got involved with LSAMP during her first year when she saw an email about a research project in partnership with Cheyney University. LSAMP students from both institutions worked with faculty on annotating videos and collecting data centered around machine learning. Bah even had the opportunity to design the front end of an application the team wanted to create for the research.

Salamata Bah, a second-year computer science major involved with Drexel-LSAMP.

Bah said this experience helped her be accepted and solidify a project for the STAR Scholars program this summer.

I chose to do something related to machine learning because I found it so interesting, she said.

Because of how much LSAMP helped shape their time at Drexel, all of these participants would encourage other eligible students to keep an eye out for emails about programming and get involved.

I wouldn't be doing half the things that I've been doing over the past six months if I just never got the email and I never signed up for it, Rath said. It's only done good things for me, basically. Its an opportunity just sitting there

You never know which one of them will help you in your career or just build the network that will help you in the future, Bah added.

Williams specifically encouraged eligible students to get involved early on in their Drexel career like she did, whether theyre students who hit the ground running or take more time to adjust.

It's really great to have someone who's like a cheerleader, who's willing to cheer you on and make sure that you're getting the resources that you need, getting involved in the things that you need to be involved in, and also just providing mental health advice and academic advice, she said. Even if you're not a student who's ready to just take on the world right once you step on the campus, it's good to have someone who's willing to guide you through that process and to also have other students and other upperclassmen who've been where you've been and who can also guide you through that process as well.

Through the years, Cox has enjoyed hearing from students how much the LSAMP program at their institution or the Philadelphia AMP Alliance as a whole benefitted their personal growth and development.

Many of them attribute their success in their life now, many of them have families and children that it had to do with working with me, because I told them that they could do anything they wanted to do if they really invested themselves in believing that they could do it, he said. Many times, while I could say that I was the catalyst for their success, the reality is they were the raw material that just needed some encouragement.

Cox will be taking the Philadelphia AMPs Phase VI grant period, which will carry the alliance through 2025 and 30 years of existence, to start grooming a predecessor to take over his role and continue with this important work.

The reality is I could probably do this forever because I really enjoy what I do, but I will be 72 in October of this year, he said. In order to ensure the same kind of energy and excitement about this continues, I need to groom some other people.

All in all, he was happy to play a part in reversing the trends he saw as a student 50 years ago, and help students not unlike himself over the past 25 years find success, motivation and community.

At one of our graduation sequences, as the students were walking across stage, I overheard [the late Drexel University President Constantine Papadakis] say, These are Steve Coxs kids, he remembered. For me, that kind of summed it up, because there are so many students that I invested my knowledge, my background in industry, my technical capacity and my belief that all students can learn, particularly underrepresented students, if they are given the opportunity.

To find out more about Drexel-LSAMP participation and programming, please contact the Director Marisol Rodriguez Mergenthal at mr444@drexel.edu.

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Changing STEM Representation Trends Through the Philadelphia AMP Alliance - DrexelNow - Drexel Now