Immatics and Molmed become the subjects of very different deals – Vantage

How do companies seal a deal when executives cannot shake hands? Maybe the management teams of Arya Sciences and Immatics bumped elbows when the latter was bought by the blank cheque company on Tuesday in a deal worth $252m. As for the Japanese group AGCs 240m ($267m) offer for Italys Molmed, presumably execs could not meet in person at all given that Italy is still locked down.

Be that as it may an acquisition and a bid have been arranged somehow, proving that though the Covid-19 pandemic has had a deadening effect on deal-making it has not annihilated it altogether. The interesting aspect is how Immatics and Molmed both cell therapy players, albeit of different kinds will develop from here.

A stark mission

Arya Sciences Acquisition Corp was set up to do what its name suggests: its sole purpose is to effect a merger or similar combination with one or more businesses. It is controlled by the hedge fund Perceptive Advisors, and floated on Nasdaq in October 2018, raising $144m.

Immatics will receive $148m of cash from Aryas trust account, which holds the IPO proceeds plus interest, when the deal closes in the second quarter. Perceptive and other institutional investors, including Redmile and Wellington Partners, have committed a further $104m more in pipe funding.

Arya saysImmatics T-cell receptor-based candidates for solid tumours hold the kind of disruptive potential the investment vehicle was looking for. Immatics has two main product classes, adoptive cell therapies, which use natural or engineered T cells against cancer, and T-cell receptor bispecifics, which bind to tumour-specific peptides and to immunomodulating T-cell surface proteins.

Gaining access to the US capital markets will allow Immatics to advance its projects through the clinic. The group expects topline phase I/II data from three TCR projects and one bispecific by the end of this year.

Going public represents a long-held goal for Immatics. The company was already eyeing the US exchanges two years ago (Why Immatics could soon become the next listed cell therapy player, July 16, 2018).

Long term

Molmed could take a very different route if AGCs bid for it is accepted, becoming a part of a much larger whole. Japans AGC is the largest glass company in the world, but is also active in the fields of ceramics, electronics and chemicals.

AGC considers its life sciences business a strategic priority, and aims to get the units sales above 100bn by 2025. Buying Molmed it is offering 0.518 per Molmed share, at a premium of 110% will allow ACG to move into gene and cell therapies.

It will not get there fast. Molmed withdrew Zalmoxis, designed to reduce the risk or rejection of an imperfectly matched stem cell transplant, from sale in Europe after a confirmatory phase III trial failed last summer. Its next most advanced product is its Car-T project CAR44v6, in a phase I/II trial for acute myeloid leukaemia and multiple myeloma. This looks unlikely to yield data before 2023.

Molmed does have another string to its bow that could appeal to AGC: it is the first company in Europe to have obtained GMP manufacturing authorisation for cell and gene therapies ex vivo, and offers this to other groups. For example, it produces Strimvelis, Orchard Therapeutics gene therapy for the immunodeficiency disorder ADA-SCID.

Closure is odds-on, since Molmeds largest shareholder, Fininvest the holding company of the family of the former Italian prime minister Silvio Berlusconi has agreed to tender its 23% stake. Hopefully, in buying this very specialised company, AGC knows what it is doing.

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Immatics and Molmed become the subjects of very different deals - Vantage

Claudia Rodrigues is removed from the clinic where she was hospitalized because of the coronavirus – Crypto Dictation

The new coronavirus is spreading all over the world and, after arriving in Brazil, has changed the lives of most Brazilians. The government's recommendation is that people stay at home and take all recommended hygiene care, thus preventing the virus from spreading in the country.

The greatest concern of the government is with the people who are part of the group considered at risk, which are the elderly and people who already have some type of chronic disease. These people are the ones most likely to have complications if they become infected with the virus.

Actress Claudia Rodrigues is one of those people who are part of the risk group and who must have redoubled health care so that it does not become contaminated with covid-19. The actress has been battling multiple sclerosis for 20 years, which is an autoimmune disease that affects the central nervous system.

The actress has already been hospitalized several times in a serious condition in times of crisis of multiple sclerosis and at the moment was hospitalized in a clinic in the state of So Paulo, following the autoimmune treatment.

Due to government recommendations and fearing contamination by covid-19, the actress was taken home.

The treatment that actress Claudia Rodrigues performed at the clinic in So Paulo is very delicate, due to her health condition in relation to multiple sclerosis, and for that reason, extra care is needed with the artist, as she already has low immunity due to disease.

Due to the situation faced by the actress, her doctors and family members chose to redouble the artist's health care and for this very reason, they decided that it was better that she be taken home and that she should remain in isolation at her residence.

Adriane Bonato, who is Claudia Rodrigues' businesswoman, revealed that the actress is at her home and that she is performing exercises on the spot. The businesswoman reaffirmed that the artist has low immunity due to having undergone stem cell transplantation and that, for this very reason, she runs a very high risk in relation to the new virus.

According to Adriane, Claudia Rodrigues will remain at home for the next 30 days, preventing herself from being infected by the new coronavirus.

Like most Brazilians, many Celebrity are at home complying with government resolutions on social isolation to prevent the mass spread of the new coronavirus. Many artists are taking advantage of the large number of followers in their profiles to try to make the population aware of the importance of following the recommendations of the Ministry of Health and especially the recommendation to be quarantined at home.

Big names like Luciano Huck, Ana Maria Braga and many others have posted videos asking Brazilians for empathy and to remain in social isolation. The artists Preta Gil and Fernanda Paes Leme, who were diagnosed with the disease, are sharing their experiences with the new coronavirus. They are keeping followers informed about how the isolation is going and the symptoms they are feeling about the coronavirus.

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Stem cells can reverse damage caused by heart attack; repair mechanism discovered: Study – International Business Times, Singapore Edition

Revolutionary Gene-Editing Tool

Cardiovascular or heart disease (CVDs) is the leading cause of death across the world. Heart attacks resulting due to CVDs can cause death, and severe damage to cardiac muscle a muscle that forms the wall of the heart in survivors. However, researchers claim that they have discovered stem-cell activated mechanisms that promote healing after a heart attack.

According to the study by researchers from Mayo Clinic, stem cells were found to reverse the damage and restore cardiac muscle back to its condition before a heart attack. Human cardiopoietic cells obtained from stem cells within the bone marrow were found to hone in on damaged proteins and reverse intricate changes that a heart attack caused.

"The response of the diseased heart to cardiopoietic stem cell treatment revealed development and growth of new blood vessels, along with new heart tissue," said Dr. Kent Arrell, first author of the study, in a statement.

For the study, the researchers examined the diseased hearts of mice. The hearts of mice that received human cardiopoietic stem cell therapy were compared with those of that did not. Nearly 4,000 cardiac proteins were identified using a data science technique to map proteins found in the cardiac muscle. Over 10 per cent of the discovered proteins were found to suffer damage as a result of a heart attack.

"While we anticipated that the stem cell treatment would produce a beneficial outcome, we were surprised how far it shifted the state of diseased hearts away from disease and back toward a healthy, pre-disease state," said Dr. Arrell.

While the organs in the human body have the ability to repair their damaged cells, they may be unable to restore the loss entirely, and this holds good for cardiac cells as well. Dr. Andre Terzic, senior author of the study, said: "The extent of change caused by a heart attack is too great for the heart to repair itself or to prevent further damage from occurring."

He explained that upon the administration of cardiopoietic stem cell therapy to mice, a partial or complete reversal of nearly two-thirds of the damage caused by a heart attack was noted. Around 85 per cent of all cellular functional categories struck by the disease responded favorably to the treatment.

According to the World Health Organisation (WHO), CVDs claim nearly 18 million lives every year, which translates to 31 per cent of all deaths. The findings of the study provide an improved understanding of the restoration of heart health using stem cells and provide a framework for wider utilization of stem cell therapy for the treatment of various conditions.

Stressing that the actual mechanism behind the repair of diseased organs by stem cells is poorly understood, Dr. Terzic added: "This study sheds light on the most intimate, yet comprehensive, regenerative mechanisms paving a road map for responsible and increasingly informed stem cell application."

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Stem cells can reverse damage caused by heart attack; repair mechanism discovered: Study - International Business Times, Singapore Edition

Newly Discovered Memory in Our Bones: Keeping a Record of Previous Infections to Boost Immunity – SciTechDaily

Immune cells by fluorescence microscopy: Blood stem cells remember a previous attack and produce more immune cells like these macrophages to fight a new infection. Credit: Sieweke lab/CIML

These findings should have a significant impact on future vaccination strategies and pave the way for new treatments of an underperforming or over-reacting immune system. The results of this research are published in Cell Stem Cell on March 12, 2020.

Stem cells in our bodies act as reservoirs of cells that divide to produce new stem cells, as well as a myriad of different types of specialized cells, required to secure tissue renewal and function. Commonly called blood stem cells, the hematopoietic stem cells (HSC) are nestled in the bone marrow, the soft tissue that is in the center of large bones such as the hips or thighs. Their role is to renew the repertoire of blood cells, including cells of the immune system which are crucial to fight infections and other diseases.

Until a decade ago, the dogma was that HSCs were unspecialized cells, blind to external signals such as infections. Only their specialized daughter cells would sense these signals and activate an immune response. But work from Prof. Michael Siewekes laboratory and others over the past years has proven this dogma wrong and shown that HSCs can actually sense external factors to specifically produce subtypes of immune cells on demand to fight an infection. Beyond their role in an emergency immune response, the question remained as to the function of HSCs in responding to repeated infectious episodes. The immune system is known to have a memory that allows it to better respond to returning infectious agents. The present study now establishes a central role for blood stem cells in this memory.

We discovered that HSCs could drive a more rapid and efficient immune response if they had previously been exposed to LPS, a bacterial molecule that mimics infection, said Dr. Sandrine Sarrazin, Inserm researcher and senior-author of the publication. Prof. Michael Sieweke, Humboldt Professor at TU Dresden, CNRS Research Director and last author of the publication, explained how they found the memory was stored within the cells: The first exposure to LPS causes marks to be deposited on the DNA of the stem cells, right around genes that are important for an immune response. Much like bookmarks, the marks on the DNA ensure that these genes are easily found, accessible and activated for a rapid response if a second infection by a similar agent was to come.

The authors further explored how the memory was inscribed on the DNA, and found C/EBP? to be the major actor, describing a new function for this factor, which is also important for emergency immune responses. Together, these findings should lead to improvements in tuning the immune system or better vaccination strategies.

The ability of the immune system to keep track of previous infections and respond more efficiently the second time they are encountered is the founding principle of vaccines. Now that we understand how blood stem cells bookmark immune response circuits, we should be able to optimize immunization strategies to broaden the protection to infectious agents. It could also more generally lead to new ways to boost the immune response when it underperforms or turn it off when it overreacts, concluded Prof. Michael Sieweke.

The research group of Prof. Michael Sieweke works at the interface of immunology and stem cell research. The scientists focus on the study of hematopoietic stem cells and macrophages, long-lived mature cells of the immune system that fulfil an important role in tissue regeneration. In 2018, Prof. Michael Sieweke received the most valuable research award in Germany: the Alexander von Humboldt Professorship, which brings top international researchers to German universities. In addition to his position as Research Director at the Centre for Immunology at the University of Marseille Luminy, he now acts as Deputy Director at the Center for Regenerative Therapies at TU Dresden (CRTD). CRTD is academic home for scientists from more than 30 nations. Their mission is to discover the principles of cell and tissue regeneration and leveraging this for recognition, treatment and reversal of diseases. The CRTD links the bench to the clinic, scientists to clinicians to pool expertise in stem cells, developmental biology, gene-editing and regeneration towards innovative therapies for neurodegenerative diseases such as Alzheimers and Parkinsons disease, hematological diseases such as leukaemia, metabolic diseases such as diabetes, retina and bone diseases.

Reference: C/EBP-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells by Brengre de Laval, Julien Maurizio, Prashanth K. Kandalla, Gabriel Brisou, Louise Simonnet, Caroline Huber, Gregory Gimenez, Orit Matcovitch-Natan, Susanne Reinhardt, Eyal David, Alexander Mildner, Achim Leutz, Bertrand Nadel, Christophe Bordi, Ido Amit, Sandrine Sarrazin and Michael H.Sieweke, 12 March 2020, Cell Stem Cell.DOI: 10.1016/j.stem.2020.01.017

This study was funded by TU Dresden / CRTD through the German Excellence Initiative, the German Research Foundation as well as through an ERC Advanced Grant from the European Research Council and the Alexander von Humboldt Foundation. The study was further supported by funding from the Institut National de la Sante et de la Recherche Medicale, the Centre National de la Recherche Scientifique, Aix-Marseille University, the Agence Nationale de la Recherche, the Foundation ARC pour la Recherche sur le Cancer, an INSERM-Helmholtz cooperation programme and the Einstein Foundation.

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The race to find a coronavirus treatment: One strategy might be just weeks away, scientists say – USA TODAY

As flu season comes to an end and allergy season starts to heat up, there may be concerns about symptoms that mimic the new coronavirus COVID-19. Wochit

MILWAUKEE, Wis. In a week whenthe coronavirus closures and quarantines hitlikefalling dominoes the lockdown in Italy,the emptyworkplaces and college campusesin the U.S., suspended sports seasons, canceled festivals far less attention fell on theglobal scientific community's driveto find treatments forthe new virus.

But researchers are already suggesting strategies tohelp patientssuffering from the virus, which is marked by fever, coughing and difficulty breathing. One treatment could be just weeks away.

With no vaccine expected anytime soon, treatmentsarecrucialtosaving the lives of thousands of the infected, especiallyhigh-riskpatients the elderly, those with compromised immune systems and those with chronic illnesses, such as diabetes, heart disease and lung disease.

"I'm very hopeful and very positive. We'll get through this,"said Robert Kruse, a doctor in the Department of Pathology at Johns Hopkins Hospitalin Baltimore. "I've been shocked this week at the measures that have been taken (to alter daily life). They were probably the correct ones, given that they have worked in other countries."

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Kruse has been pursuing two different treatmentstrategies, one of which has a long history andcould be availablewithinweeks rather than months. The quickest option is likely to be the use ofantibodies from recovered COVID-19 patients. As of Saturday, there were almost 72,000 such patients worldwide. Thevirus has infected about 150,000, killing more than 5,500.

The use of survivor antibodies, serum therapy,dates back to 1891 when it was used successfully to treat a child with diphtheria. Since then, serum from recovered patients has been used "to stem outbreaks of viral diseases such as poliomyelitis, measles, mumps and influenza," according to a paperFriday in The Journal of Clinical Investigation.

"As we are in the midst of a worldwide pandemic, we recommend that institutions consider the emergency use (of serum from recovered patients) and begin preparations as soon as possible. Time is of the essence," wrote the paper's two authors, Arturo Casadevall of Johns Hopkins School of Public Health, and Liise-anne Pirofski of the Albert Einstein College of Medicine in New York.

All of the strategies, including the use of serum from recovered patients, have drawbacks. Transfusion of serum carries potential side effects, including fever, allergic reactions, and a very small risk of infectious disease transmission.

Collecting large amounts of serum from recovered patients could be a sizable task. It could turn outthat serum from one recovered patient is only enough to save a singlesick one, explainedKruse at Johns Hopkins. "It's a logistical challenge to put it together, but at the very least there are no hurdles (from the U.S. Food and Drug Administration)to producing the therapy."

Kruse advanced anothertechnique in a paper published in late Januaryin the journal F1000 Research.

His method seeks to take advantage of the new coronavirus' ability to latch onto and enter cells.

Scientists often talk about "cell receptors," which are essentially doors that allow a virus to enter the cell.

The "door" the new coronavirus is entering through is known as the ACE-2 protein. Kruse's technique involves detaching the externalportionof ACE-2, which would act as a decoy for the virus. Thevirus would bind tothe decoy, leaving it unable to reachtheactual door into the cell, and thus, unable tocause infection.

"It won't realize, 'Oh gosh, this isn't a cell,'" Kruse explained in an interview. "The virus can't mutate away from this."

Kruse'sdecoy therapy would not be available until fall at the earliest. However, a similar version of the strategy is currently being tested in trials in China.

Afaster optioninvolves what's called "repurposing" a drug.

This is when a drug that has already been found safe and approved fortreatment of one disease also is foundusefulin treating another. One example is thedrug Sildenafil, which is sold as Viagra andused to treat both erectile dysfunction andpulmonary hypertension.

There are three ways in which scientists try to findan existing drug that can treat a new condition.

The rational method involves using drugs that have characteristics and targets that suggestthey might be used to treatthe new condition.

The computational method involves examining protein structures and using them to predict an existing drug that might work.

The final method takes advantage of the vast drug libraries possessed by companies and academic institutions. High-speed technology allows researchers to screen thousands of drugs very quickly to determine whether they will act against a specific target.

Considerable hope,interest and money have been invested in one drug not previously approved, remdesivir. The drug was previously tested against Ebola, but failed in trials.

Gilead Sciences, a Foster City, California-based biopharmaceutical company,announced that two clinical studies of the drugare beginning thismonth. Two more clinical trials of the drug are already underway in China.

In the U.S., the clinical trials process is slow and painstaking, takingseveral years andsometimes much longer.

Another approach to the new virus championed by numerous researchers isthe use oflab-made proteinscalled monoclonal antibodies.

These confer what's called "passive immunity" and have been used previously to treat cancer, multiple sclerosis,cardiovascular disease and many other conditions.

"The use of monoclonal antibodies is a new era in infectious disease prevention which overcomes many drawbacks associated with serum therapy ... in terms of specificity, purity, low risk of blood-borne pathogen contamination and safety," wrote the authors of a recent paper in the Asian Pacific Journal of Allergy and Immunology.

The biotechnology company Regeneron, based in Tarrytown, New York, started work searching for a monoclonal antibody "for this particular virus in early/mid-January," said Christos Kyratsous, the company's vice president for infectious diseases and viral vector technologies. "But really we started working on it decades ago when we began building our unique end-to-end drug discovery and development technologies."

Gregory Poland, director of Mayo Clinic's Vaccine Research Group, said the use of monoclonal antibodies "needs to be designed and tested in this specific disease, but I wouldn't see any reason it wouldn't work. The idea is right."

Like other scientists, Poland was less hopeful that a vaccine would be developed anytime soon.

"We won't have a vaccine for this outbreak," he said. "It will be before thenext (outbreak)."

Monoclonal antibodies do havepitfalls. They require extensive testing. Also, viruses can mutate and escape from the antibodies. Companies sometimestarget two different parts of the virus to make it harder for the virusto mutate and elude the antibodies.

Ajay K. Sethi,associate professor of population health sciences at the University of Wisconsin-Madison, expressed support for the development of monoclonal antibodies.

"In my opinion, trying a strategy like monoclonal antibodies to provide passive immunity is a good idea," Sethi said.He added that given the technique's past successes, "it is hopeful, but not surprising."

Strategies forcombating the new coronavirus will likely requirereaching patients early before they get too sick. Toward that end, Kruse said he believes the U.S. should pursue the much broader coronavirus testing policythat South Koreaadopted.

"Maybe in the next few weeks we will get to the point where we are testing everyone," he said.

Take a break from coronavirus news: The 12 adorable baby animal photos you need right now

Coronavirus: Here are some TikToks and memes to get you through the panic

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The race to find a coronavirus treatment: One strategy might be just weeks away, scientists say - USA TODAY

Woman meets stranger who saved her life and allowed her to become a mum – Mirror Online

As Jo Kelly met her hero for the first time, she struggled to find the words to thank him for the two most precious of gifts.

Stem cell donor Stefan Berens did not just save Jo after she was given only months to live. He also gave her the opportunity to become a mum to baby Phoebe.

So Jo showed her gratitude the only way she could. She embraced Stefan then introduced him to her beautiful daughter.

Jo, 34, said: Meeting Stefan was one of the best experiences of my life. It felt like meeting long-lost family. He called me his blood sister, so I knew he felt the same way.

Introducing him to Phoebe was like showing him the ultimate symbol of my recovery. If it wasnt for him, she wouldnt be here. I can feel myself getting tearful when I say that.

Stefan, 32, an economist from Germany, said: I was very nervous about meeting Jo, but it felt so natural. There was a unique bond between us. Meeting Phoebe was the cherry on top, realising she wouldnt exist without me. I am so happy for them.

Jo was just 22 when she was diagnosed with blood cancer Hodgkin Lymphoma in 2007. Despite intensive radiotherapy and chemotherapy, the cancer spread to her lungs and bones.

Three years later, doctors told her the cancer was terminal and she would not live to see Christmas.

Jo had been dating Pete Ames, himself a testicular cancer survivor, for just six months. She said: A few weeks later, we were painting my room and Pete burst into tears. He said he didnt want me to leave this world not being his wife.

Business analyst Pete, now 35, decorated his house with fairy lights and wrote, I love you on the walls in 25 different languages to pop the question. The couple then planned their wedding in just eight weeks.

Jo said: I had an IV drip taped to the underside of my arm, but it was an incredible day.

Days before the wedding, Jo was given a new drug which stopped the cancer progressing, before another drug sent it into remission. For the first time, Jo was stable enough for a stem-cell transplant.

But blood disease charity Anthony Nolan only found one potential lifesaver with a matching tissue type on the worldwide register. That person was Stefan, who joined the register in his home town of Bielefeld, North West Germany.

Jo said: We were terrified he might not want to go through with it, but everything fell into place.

Stefan said: My question was never, Should I do this?. It was, How do I help?.

Stefan made the 360-mile round trip from Hamburg, where he was an intern, to a clinic in Berlin to donate. Jo had her transplant in 2012, but the chemo she needed to kill off her immune system before she received Stefans cells left her so weak she nearly died.

She said: There was one night where I hit rock bottom. I knew if I chose, I could pass away quietly. But I had to keep trying for Pete and my parents.

Jo slowly recovered and wrote a thank you letter to Stefan shortly after the life-saving transplant.

She never received Stefans reply and believes it was delivered to an old address.

Their incredible story might have ended there. But nearly two years ago Jo, who was left infertile by the chemotherapy before her transplant, tried for a baby with husband Pete via IVF.

An embryo made using Petes sperm and a donor egg was implanted in Jos womb. Phoebe was born in March last year and celebrated her first birthday last Thursday.

Jo, a data engineer from Lichfield, Staffs, said: I still marvel at the fact this little soul wasnt really meant to exist, yet she is so special.

Having Phoebe felt like such a big moment, I had to try to tell my donor. Im so glad I did.

Stefan agreed. It was a little bit heartbreaking to find out that Jo didnt receive my first letter. Im so pleased she wrote again. Jo also developed a new passion for running, which she shares with Stefan. She completed the London Marathon on her 33rd birthday in 2018.

When Jo met Stefan in Manchester, she presented him with her marathon medal to thank him for everything. Jo said: It belongs to Stefan as much as me, I wouldnt have it without him.

We joked that he gave me his love of running along with his stem cells.

And she added: Meeting Stefan feels like a fitting conclusion to a huge chapter of my life. I dont know what the future holds, but I hope I can keep in touch with my blood brother.

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Cancer Stem Cell Therapy Market Global Size, Demand-sales, Suppliers by Key Applications 2019 Detailed Analysis and Growth Aspects on Manufacturing…

In this report, the global Cancer Stem Cell Therapy market is valued at USD XX million in 2019 and is projected to reach USD XX million by the end of 2025, growing at a CAGR of XX% during the period 2019 to 2025.

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The following manufacturers are covered:AVIVA BioSciencesAdnaGenAdvanced Cell DiagnosticsSilicon Biosystems

Segment by RegionsNorth AmericaEuropeChinaJapanSoutheast AsiaIndia

Segment by TypeAutologous Stem Cell TransplantsAllogeneic Stem Cell TransplantsSyngeneic Stem Cell TransplantsOther

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Cancer Stem Cell Therapy Market Global Size, Demand-sales, Suppliers by Key Applications 2019 Detailed Analysis and Growth Aspects on Manufacturing...

Stem Cell Manufacturing Market Analysis By Recent Trends, Developments In Top Manufacturing Technology And Regional Growth Overview And Forecast To…

The Insight Partners delivers well-researched industry-wide information on the Stem Cell Manufacturing market. It provides information on the markets essential aspects such as top participants, factors driving Stem Cell Manufacturing market growth, precise estimation of the Stem Cell Manufacturing market size, upcoming trends, changes in consumer behavioral pattern, markets competitive landscape, key market vendors, and other market features to gain an in-depth analysis of the market. Additionally, the report is a compilation of both qualitative and quantitative assessment by industry experts, as well as industry participants across the value chain. The report also focuses on the latest developments that can enhance the performance of various market segments.

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Stem cell manufacturing discusses the required technologies that enable the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic environment as therapeutics, while concurrently achieving control, reproducibility, automation, validation, and safety of the process and the product.

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Key vendors engaged in the Stem Cell Manufacturing market and covered in this report:

The report also includes the profiles of key stem cell manufacturing companies along with their SWOT analysis and market strategies. In addition, the report focuses on leading industry players with information such as company profiles, products and services offered, financial information of last 3 years, key development in past five years. Some of the key players influencing the market are Merck KGaA, Thermo Fisher Scientific, Inc., BD, Bio-Rad Laboratories, Inc., Miltenyi Biotec, Pharmicell Co., Ltd, Takara Bio Inc., STEMCELL Technologies Inc., Osiris Therapeutics, Inc., and NuVasive, Inc. among others.

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Stem Cell Manufacturing Market Analysis By Recent Trends, Developments In Top Manufacturing Technology And Regional Growth Overview And Forecast To...

Kuur Therapeutics Launches to Develop and Commercialize Off-the-shelf CAR-NKT Cell Therapies Targeting Hematological and Solid Tumors | DNA RNA and…

DetailsCategory: DNA RNA and CellsPublished on Wednesday, 11 March 2020 09:29Hits: 358

HOUSTON, TX, USA I March 10, 2020 I Kuur Therapeutics today announced the launch of its new business in partnership with Baylor College of Medicine and Baylors Center for Cell and Gene Therapy. Houston-based Kuur Therapeutics will advance the work of its predecessor, Cell Medica, to develop anti-cancer therapies using its innovative chimeric antigen receptor natural killer T cell (CAR-NKT) therapy platform.

IP Group, Baylor College of Medicine and Schroeder Adveq are investing to support two phase 1 studies: GINAKIT 2 (autologous CAR-NKT cells in neuroblastoma) and ANCHOR (allogeneic CAR-NKT cells in CD19 malignancy). The ongoing GINAKIT2 study is now enrolling patients at the third dose level and the ANCHOR study IND has recently been approved by the FDA, with first patient treatment expected in 1H 2020. The funding will also support the preclinical development of an allogeneic CAR-NKT product for treatment of hepatocellular carcinoma, ahead of an IND submission anticipated in 1H 2021.

In conjunction with the new investment, Kevin S Boyle, Sr, was named CEO of Kuur, succeeding Chris Nowers. Mr Boyle joined Cell Medica as CFO in February 2018. Kevin previously held senior finance roles at both NASDAQ-listed and private equity backed companies. He is an accomplished capital markets professional, having raised over $2.0 billion in equity and debt capital.

Kuurs novel CAR-NKT platform is a next-generation technology of engineered immune cells with enhanced functions for the treatment of hematological and solid tumors. It utilizes the unique properties of NKT cells, a specialized type of innate lymphocyte, which shares properties with both T and NK cells. This platform, developed in the laboratory of Baylor Principal Investigator Leonid Metelitsa, is exclusively licensed to Kuur by its partner and collaborator, Baylor College of Medicine.

Annalisa Jenkins, Chair of Kuurs Board, said: We are fortunate to have Kevin step up to the role of CEO. He will act as a change agent, leading the company during a crucial period for our clinical trials and working to secure the additional capital required to progress our two lead CAR-NKT products through the clinic.

The Board would also like to thank Chris for his exceptional leadership during a transition period that has resulted in a company on the right path forward for its investors, with a focus on its important collaborations.

Kevin S Boyle, Sr, Kuurs CEO, said: I am excited to lead Kuur Therapeutics at such a pivotal moment. We are making final preparations to take our off-the-shelf program into the clinic and believe the allogeneic approach holds huge promise for unlocking the potential of CAR therapies for large patient populations. Compared with patient-specific autologous CAR products, it is immediately available for treatment and less expensive to manufacture.

Leonid S. Metelitsa, BCM Principal Investigator, said: My goal is to make a difference in the lives of cancer patients, especially children, and Im excited to be working with the Kuur team to make this goal a reality. I believe that the NKT-cell platform technology, developed in my laboratory and progressed to first-in-human clinical testing in close collaboration with colleagues at BCM and Texas Childrens Hospital, offers a unique route to next-generation off-the-shelf CAR therapies for a broad range of malignancies.

About Kuur Therapeutics

Kuur Therapeutics, headquartered in Houston, is a clinical-stage biotechnology company focused on transforming the treatment of solid and hematological cancers by developing next generation chimeric antigen receptor-natural killer T cell (CAR-NKT) therapies. Developing a portfolio of primarily allogeneic therapies, the company's revolutionary platform spanning both hematological and solid tumors is being created in partnership with Baylor College of Medicine and Baylor's Center for Cell and Gene Therapy.

For further information, please visit http://www.kuurtx.com. Follow Kuur Therapeutics on LinkedIn

About Kuur's CAR-NKT cell technology

One of the challenges with allogeneic therapies is that infusing a patient with donor-derived lymphocytes can induce graft versus host disease (GvHD), a potentially life-threatening condition in which the infused cells recognize the patient's tissues as foreign. The NKT cells used in Cell Medica's CAR-NKT platform have an invariant T cell receptor (iTCR) that does not distinguish between self- and non-self tissues, making them unlikely to induce GvHD when given to another person. Kuur's CAR-NKT cells are also engineered to secrete IL-15, to prolong persistence and enhance anti-tumor activity.

Baylor has previously reported evidence of clinical activity and a good safety profile in neuroblastoma patients treated at low dose levels of autologous CAR-NKT cells at the 2019 American Society for Gene and Cell Therapy conference.

About Baylor College of Medicine

Baylor College of Medicine (www.bcm.edu) in Houston is recognized as a premier academic health sciences center and is known for excellence in education, research and patient care. It is the only private medical school in the greater southwest and is ranked 16th among medical schools for research and 5th for primary care by U.S. News & World Report. Baylor is listed 21st among all U.S. medical schools for National Institutes of Health funding and number one in Texas. Located in the Texas Medical Center, Baylor has affiliations with seven teaching hospitals and jointly owns and operates Baylor St. Luke's Medical Center, part of CHI St. Luke's Health. Currently, Baylor trains more than 3,000 medical, graduate, nurse anesthesia, physician assistant and orthotics students, as well as residents and post-doctoral fellows.

Follow Baylor College of Medicine on Facebook (http://www.facebook.com/BaylorCollegeOfMedicine) and Twitter (http://twitter.com/BCMHouston).

About the Baylor College of Medicine Center for Cell and Gene Therapy

The Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital in Houston, Texas is led by Helen E Heslop, MD, DSc (Hon), Director and Malcolm K Brenner, MD, PhD, Founding Director. The Center for Cell and Gene Therapy provides an infrastructure to rapidly translate novel cell and gene therapy protocols from the laboratory to the clinic. The comprehensive approach of the center brings a wide variety of scientists and clinicians together to develop strategies for the treatment of cancer, HIV and cardiovascular disease. Patient facilities include the adult stem cell transplant unit at Houston Methodist Hospital and the pediatric stem cell transplant unit at Texas Children's Hospital.

SOURCE: Kuur Therapeutics

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Kuur Therapeutics Launches to Develop and Commercialize Off-the-shelf CAR-NKT Cell Therapies Targeting Hematological and Solid Tumors | DNA RNA and...

The London Patient, Cured of H.I.V., Reveals His Identity – The New York Times

For Mr. Castillejo, the experience was surreal. He watched as millions of people reacted to the news of his cure and speculated about his identity. I was watching TV, and its, like, OK, theyre talking about me, he said. It was very strange, a very weird place to be. But he remained resolute in his decision to remain private until a few weeks ago.

For one, his doctors are more certain now that he is virus-free. We think this is a cure now, because its been another year and weve done a few more tests, said his virologist, Dr. Ravindra Gupta of the University of Cambridge.

Mr. Castillejo also tested his own readiness in small ways. He set up a separate email address and telephone number for his life as LP, as he refers to himself, and opened a Twitter account. He began talking weekly with Mr. Brown, the only other person who could truly understand what he had been through. In December, Mr. Castillejo prepared a statement to be read aloud by a producer on BBC Radio 4.

After talking through his decision with his doctors, friends and mother, he decided the time was right to tell his story.

I dont want people to think, Oh, youve been chosen, he said. No, it just happened. I was in the right place, probably at the right time, when it happened.

Mr. Castillejo grew up in Caracas, Venezuela. His father was of Spanish and Dutch descent which later turned out to be crucial and served as a pilot for an ecotourism company. Mr. Castillejo speaks reverently of his father, who died 20 years ago, and bears a strong resemblance to him. But his parents divorced when he was young, so he was primarily raised by his industrious mother, who now lives in London with him. She taught me to be the best I could be, no matter what, he said.

As a young man, Mr. Castillejo made his way first to Copenhagen and then to London in 2002. He was found to have H.I.V., the virus that causes AIDS, in 2003.

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The London Patient, Cured of H.I.V., Reveals His Identity - The New York Times