One of Wall Street’s most high-profile hedge funds pushes Alexion’s CEO to the auction block and he’s not budging – Endpoints News

Exhilarating. A major advance. A milestone achievement. If one had just tuned into the panel comments on Biogens presentation at CTAD, it would seem that the biotech had an impressive, disease-modifying Alzheimers drug in aducanumab.

But off the stage, reactions to their admittedly complicated dataset and the biotechs explanation for resurrecting a drug that failed its futility analysis were a lot more mixed, with analysts continuing to question whether the evidence is substantial enough to warrant an FDA approval and raising new doubts on the safety side.

In an investor call later in the day, execs noted that they are not planning another study and stood by their intention, publicized in October to much surprise, to submit regulatory filings based on what they have.

We dont file willy nilly, said Al Sandrock, head of R&D. We only go to filing when we believe that there is a benefit-risk argument based on science, based on data. And if you look at our history, we havent done filings right and left without good reason.

Biogen had a theory going into the Clinical Trials on Alzheimers Disease meeting.

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One of Wall Street's most high-profile hedge funds pushes Alexion's CEO to the auction block and he's not budging - Endpoints News

Mayo Clinic Transplant Center – Regenerative medicine …

Mayo Clinic Regenerative Medicine Consult Service

At Mayo Clinic, an integrated team, including stem cell biologists, bioengineers, doctors and scientists, work together and study regenerative medicine. The goal of the team is to treat diseases using novel therapies, such as stem cell therapy and bioengineering. Doctors in transplant medicine and transplant surgery have pioneered the study of regenerative medicine during the past five decades, and doctors continue to study new innovations in transplant medicine and surgery.

In stem cell therapy, or regenerative medicine, researchers study how stem cells may be used to replace, repair, reprogram or renew your diseased cells. Stem cells are able to grow and develop into many different types of cells in your body. Stem cell therapy may use adult cells that have been genetically reprogrammed in the laboratory (induced pluripotent stem cells), your own adult stem cells that have been reprogrammed or cells developed from an embryo (embryonic stem cells).

Researchers also study and test how reprogrammed stem cells may be turned into specialized cells that can repair or regenerate cells in your heart, blood, nerves and other parts of your body. These stem cells have the potential to treat many conditions. Stem cells also may be studied to understand how other conditions occur, to develop and test new medications, and for other research.

Researchers across Mayo Clinic, with coordination through the Center for Regenerative Medicine, are discovering, translating and applying stem cell therapy as a potential treatment for cardiovascular diseases, diabetes, degenerative joint conditions, brain and nervous system (neurological) conditions, such as Parkinson's disease, and many other conditions. For example, researchers are studying the possibility of using stem cell therapy to repair or regenerate injured heart tissue to treat many types of cardiovascular diseases, from adult acquired disorders to congenital diseases. Read about regenerative medicine research for hypoplastic left heart syndrome.

Cardiovascular diseases, neurological conditions and diabetes have been extensively studied in stem cell therapy research. They've been studied because the stem cells affected in these conditions have been the same cell types that have been generated in the laboratory from various types of stem cells. Thus, translating stem cell therapy to a potential treatment for people with these conditions may be a realistic goal for the future of transplant medicine and surgery.

Researchers conduct ongoing studies in stem cell therapy. However, research and development of stem cell therapy is unpredictable and depends on many factors, including regulatory guidelines, funding sources and recent successes in stem cell therapy. Mayo Clinic researchers aim to expand research and development of stem cell therapy in the future, while keeping the safety of patients as their primary concern.

Mayo Clinic offers stem cell transplant (bone marrow transplant) for people who've had leukemia, lymphoma or other conditions that have been treated with chemotherapy.

Mayo Clinic currently offers a specialty consult service for regenerative medicine within the Transplant Center, the first consult service established in the United States to provide guidance for patients and families regarding stem cell-based protocols. This consult service provides education and consultation for people with many conditions who have questions about the potential use of stem cell therapy. The staff provides guidance to determine whether stem cell clinical trials are appropriate for these individuals. Regenerative medicine staff may be consulted if a doctor or patient has asked about the potential use of stem cell therapies for many conditions, including degenerative or congenital diseases of the heart, liver, pancreas or lungs.

People sometimes have misconceptions about the use and applications of stem cell therapies. This consult service provides people with educational guidance and appropriate referrals to research studies and clinical trials in stem cell therapies for the heart, liver, pancreas and other organs. Also, the consult service supports ongoing regenerative medicine research activities within Mayo Clinic, from basic science to clinical protocols.

Read more about stem cells.

For more information about Mayo Clinic's regenerative medicine consultation service, please call 844-276-2003 (toll free) Monday through Friday from 8 a.m. to 5 p.m. Central time.

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Oct. 10, 2019

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Allogene allies with Notch to make CAR-T production more scalable – BioPharma-Reporter.com

Last year, Arie Belldegrun and David Chang, fresh from selling chimeric antigen receptor (CAR)-T pioneer Kite Pharma to Gilead Sciences, launched Allogene with $300m (271m) and a deal with Pfizer to access off-the-shelf cell therapies. The focus then, as now, was on taking CAR-T therapies mainstream by eliminating factors that could restrict them to niche status, such as the complex, costly production process.

Allogenes founding allogeneic technology moves it some way toward that goal, by enabling therapies to be made from donor cells rather than having to engineer cells taken from the patient themselves.

However, even if the allogeneic approach works as Allogene hopes, it will still require a steady supply of donor cells. When Allogene launched, it set its sights on making up to 100 doses from one donor sample.

The finite nature of donated T cells has spurred interest in induced pluripotent stem cells (iPSC), which could serve as a renewable source of materials for off-the-shelf CAR-T therapies. Notchs work to realize that potential caught the attention of Allogenes CEO, David Chang.

Chang said, We believe [it] to be a scalable and potentially more [good manufacturing practice] amenable manufacturing process. It might be amenable for large-scale manufacturing.

The early stage nature of the iPSC technology Notch is yet to enter the clinic means it is unclear whether the approach can live up to those expectations. An inability to show CAR-T doses are free from undifferentiated iPSCs and failure to generate functioning T cells from iPSCs are two potential stumbling blocks.

Allogene has seen enough potential to bet on Notch, though. The deal will see Allogene pay Notch $10m upfront, take a 25% stake in its new partner and commit to a package of milestones.

Notch will take iPSC AlloCAR T cells through preclinical development before Allogene steps in to test them in humans. Allogene will have global rights to any products resulting from the collaboration.

Other companies are also working to develop oncology cell therapies based on iPSCs. Fate Therapeutics is trialling an engineered natural killer cell therapy created from a clonal master iPSC line, while Bayer-backed startup Century Therapeutics recently raised $250m to take iPSC-derived treatments for blood cancers and solid tumors into the clinic. Takeda is also active in the space.

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Allogene allies with Notch to make CAR-T production more scalable - BioPharma-Reporter.com

Stem cell Manufacturing Market: is predicted to reach a valuation of by 2027 – Weekly Spy

Global Stem cell manufacturing Industry Analysis of the value chain helps to analyze major raw materials, major equipment, production processes, customer analysis and major Stem cell manufacturing Market distributors. A comprehensive analysis of the statistics, market share, performance of the company, historical analysis Till 2018, volume, revenue, growth rate of YOY and CAGR forecast for 2027 is included in the report. Research Report also provides explicit information in recent years on mergers, acquisitions, joint ventures and other important market activities. Research Analysis report also provides Porter analysis, PESTEL analysis and market attractiveness to better understand the macro-and micro-level market scenario. Stem cell manufacturing report also includes a detailed description, a competitive scenario, a wide range of market leaders and business strategies adopted by competitors with their analysis of SWOT.

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Stem cell manufacturing discusses the required technologies that enable the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic environment as therapeutics, while concurrently achieving control, reproducibility, automation, validation, and safety of the process and the product.

The market of stem cell manufacturing is anticipated to grow with a significant rate in the coming years, owing to the factors such as, growing public-private investments and funding in stem cell-based research, rising public awareness regarding the therapeutic potency of stem cell products, development of advanced genomic analysis techniques for quality control during stem cell manufacturing, technological advancements in stem cell manufacturing and preservation, and evolving regulatory frameworks for stem cell therapeutics.

The report also includes the profiles of key stem cell manufacturing companies along with their SWOT analysis and market strategies. In addition, the report focuses on leading industry players with information such as company profiles, products and services offered, financial information of last 3 years, key development in past five years. Some of the key players influencing the market are Merck KGaA, Thermo Fisher Scientific, Inc., BD, Bio-Rad Laboratories, Inc., Miltenyi Biotec, Pharmicell Co., Ltd, Takara Bio Inc., STEMCELL Technologies Inc., Osiris Therapeutics, Inc., and NuVasive, Inc. among others.

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The Global Stem cell manufacturing Market Analysis to 2027 is a specialized and in-depth study of the biotechnology industry with a focus on the global market trend. The report aims to provide an overview of global stem cell manufacturing market with detailed market segmentation by of product, application and end user. The global stem cell manufacturing market is expected to witness high growth during the forecast period. The report provides key statistics on the market status of the leading market players and offers key trends and opportunities in the market. On the other hand, increasing market focus on embryonic stem cells and induced pluripotent stem cells are expected to offer new growth platforms to conduct advanced research and developments for the players in the global stem cell manufacturing market.

Market segmentation:

Stem Cell Manufacturing Market to 2027 Global Analysis and Forecasts By Product (Stem Cell Lines, Instruments, Culture Media, And Consumables) Application (Research Applications, Clinical Applications, and Cell and Tissue Banking) End User (Pharmaceutical and Biotechnology Companies, Hospitals and Surgical Centers, Academic Institutes, Research Laboratories, and Cros, Cell Banks, and Tissue Banks) and Geography

By Geography North America, Europe, Asia-Pacific (APAC), Middle East and Africa (MEA) and South & Central America. And 13 countries globally along with current trend and opportunities prevailing in the region.

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Stem cell Manufacturing Market: is predicted to reach a valuation of by 2027 - Weekly Spy

Vertex invests in gene therapy manufacturing – BioPharma-Reporter.com

Across 2019, Vertex has struck deals intended to yield a new generation of breakthrough medicines.

In June, Vertex agreed to pay $245m (220m) upfront to acquire Exonics Therapeutics for its gene editing technology and pipeline of programs targeting diseases including Duchenne muscular dystrophy (DMD). Months later, Vertex put up another $950m to buy Semma Therapeutics and its cell therapy treatment for type I diabetes.

The acquisitions moved Vertex, which started out in small molecules, into new areas, and building out capabilities in those areas will cost money.

In recent years, Vertex has grown its annual operating expenses by 10% to 14%. Talking on a recent quarterly results conference call, Vertex CFO Charles Wagner warned investors to expect costs to rise faster in 2020.

Wagner said, Our current expectation is that the rate of growth will be somewhat higher in 2020 as we invest in research and preclinical manufacturing for selling genetic therapies in support of our programs in type I diabetes, DMD and other diseases.

The move into type I diabetes also takes Vertex into territory that, to some observers, looks different than the areas the company has targeted historically.

Asked by an analyst about the shift in focus, Vertex CEO Jeff Leiden downplayed the differences, noting that type I diabetes is treated in the US in a relatively small number ofcenters that can be targeted by a speciality sales force.

Researchers have achieved positive, long-term outcomes by transplanting cadaveric islets into patients but two barriers have stopped companies from industrialising that approach.

Firstly, there are too few cadaveric islets to treat all type I diabetics. Secondly, immunosuppression is needed to stop patients from rejecting the transplanted cells.

Semma is trying to tackle the problems by differentiating stem cells and using a device to protect them from the immune system. Vertex thinks these technologies are the breakthroughs the field needs to industrialize the concept.

Leiden said, We were watching companies who are addressing those two problems for the last two, three years. And over the last six to eight months, we were convinced that Semma has actually solved both of those problems.

Vertex reached that conclusion on the strength of preclinical data. Now, Vertex is set to invest to find out whether the idea works in the clinic.

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Vertex invests in gene therapy manufacturing - BioPharma-Reporter.com

[Weekly Funding Roundup] Startups raised $53.3M, a drop of 75.8 pc from last week – YourStory

This week, startups raised $53.3 million in equity funding, down 75.8 percent as compared to last week's $220.7 million. Three venture debt deals were also signed that saw startups raising a total of $6.1 million.

Weekly Funding Roundup

PayU co-founder Jitendra Guptas latest venture, Digifin raised $24 million in an early-stage round from Matrix Partners, Sequoia Capital, Greyhound Capital, 3One4 Capital, Rocket Internet, BeeNext, and Tanglin Venture Partners. The company operates under Amica Financial Technologies.

Exam preparation startup Gradeup this week said it had received $7 million in Series A funding from Times Internet. This is the second fundraise for Gradeup, taking the total funds raised by the startup to $10 million. Gradeup will use the funds to enhance its technology and product capabilities, diversify offerings, and scale its academic team.

Online learning platform Adda247 raised Series B funding of $6 million led by Infoedge (India) Ltd and Asha Impact. STL, a current investor of Adda247, also participated in the latest round. With this round, Adda247 has raised a total of $10 million of funds to date.

Delhi-based healthcare platform BeYouPlus raised$3.2 millionin its Series A funding round, led byIvyCap Ventures.The round also saw participation fromMadison CapitalandSingapore Angel Network, among others.

SafeHouse Technologies, that focusses on mobile-first cybersecurity, raised $2.2 million in a seed funding round led by Barclays UK Ventures, the venture capital business unit of British multinational financial services group Barclays.

Residential proptech startup YourOwnROOM raised $1.3 million in seed fundingfrom a group of investors that includes US-based investment firm Lotus Capital; Ravi Chaturvedi, former President of P&G; Narasimha Murthy, Co-founder of a US-based healthtech company; and a group of angel investors based out of the USand Bengaluru.

Bengaluru-based transport service for kids, PiggyRide raised $1.05 million (Rs 7.5 crore) led by JAFCO Investment Asia Pacific, along with a clutch of angel investors, including InMobis Naveen Tewari; Livspace Co-founders Ramakant Sharma and Anuj Srivastava; Goldman Sachs' MD, Niladri Mukhopadhyay; Zipdials Amiya Pathak; and EzCreds Sachin Maheshwari.

Pet-care platform Wiggles raised angel funding of $1 million from investors such asNachikhet Deshpande, COO of L&T Infotech; Aparna Badkundri, Director, Dell Computers; Sachin Phadke, MD of Vetbiochem India; Abhay Amrute, Senior Partner, IIFL Wealth Management Ltd; Satish Billakota, VP, Europe Cognizant; Risshee Tandulwadkar, Founder, Solo Stem Cell Clinic, apart from a few other HNIs.

Mumbai-based edtech startup ENpower, which provides entrepreneurship learning programmes for teenagers, raised seed funding of $0.37 million (Rs 2.65 crore) from an investor consortium led by Nikhil Vora, Founder & CEO of Sixth Sense Ventures, a consumer-centric venture fund.

The Knotty Tales, a tech startup that acts as a digital wedding planning platform, raised $0.06 million from a group of angel investors as a part of its seed round. This fundraising will be used to focus on new product innovation and further strengthening relationships with clients and vendors.

Seed investor Venture Catalysts invested an undisclosed amount in deep-tech computer vision and augmented reality (AR) specific startup peAR Technologies.

Mitrata Financial Services, a women-focussed microlender, raised Series A funding from a group of individual investors. Sadaf Sayeed, CEO of Muthoot Microfin, was one of the investors in Mitrata.

Mumbai-based podcast startup Kuku FM raised an undisclosed amount from the dream team of VCs 3one4 Capital, Shunwei Capital (a Chinese investment firm spun off from handset-maker Xiaomi), and India Quotient. This investment has raised the bar for the Kuku FM team. The funds raised will be used to expand its content library and increase its user base.

Vehicle maintenance startup Hoopy raised an undisclosed amount of funding from Lead Angels and Venture Farmer. Bengaluru-based family office Venture Farmer typically makes Pre-Series A to Series B investments ranging between $100k-$700k.

Delhi-based startup goStops, a premium chain of youth traveller hostels, raised an undisclosed amount of funds in its initial funding round from angel investors.

Corefactors, an integrated sales and marketing company, raised an undisclosed amount in its seed round from Mumbai based angel investment firm, Ah! Ventures.

There was one late-stage deal this week. Omnichannel furniture brand Urban Ladder has raised close to $2.1 million (Rs 14.91 crore) from SAIF Partners, Steadview Capital and Sequoia Capital India, as a follow-on of its Series E round, according to regulatory filings accessed by YourStory.

News and classifieds platform Lokal raised $3 million from 3one4 Capital, Y Combinator, RB Investments, SOMA Capital, and its existing investor India Quotient. Focused on regional languages, Lokal will be using the freshly raised funds to improve its product and expand to newer geographies.

Data, analytics, and decisioning company Experian has picked up a strategic stake in smart data mobile marketing platform Vserv Digital Services. While the deal size and amount were undisclosed, the company stated the investment was in line with its vision to boost financial inclusion, by ensuring a friction-free digital onboarding experience for its consumers.

Hyderabad-based Thinkwide PGO raised $1 million in equity funding from Sreeni Musani of Ektha Pvt. Ltd. and Narsi Reddy Posham of IRA Reality Pvt. Ltd. The startup has also received an additional commitment of $1 million in equity investment from the same set of investors.

Online furniture rental firm Furlenco raised Rs 2.5 crore ($1.6 million) debt funding from Sandeep Baid, Shakuntalam Holdings, and Ritona Vincom.The company has issued 250 non-convertible debentures (NCDs) of face value Rs 1 lakh each for the same.

Consumer and small and medium enterprises (SMEs) focussed digital lending app InCred raised Rs 31.4 crore ($4.4 million) in its second round of debt financing.

Furniture and electronics leasing platform, Rentomojo raised Rs 1 crore ($0.14 million) as non-convertible debentures (NCDs) from Kamal Bhandari on private placement basis.

Used vehicle marketplace Droom acquired NBFC Xeraphin Finvest Pvt. Ltd.

SoftBank-backed robotic process automation (RPA) player Automation Anywhere which acqui-hired engineering startup Cathyos Labs.

And finally, Netcore Solutions acquiredAI startup Boxx.ai.

(Edited by Suman Singh and Saheli Sen Gupta)

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[Weekly Funding Roundup] Startups raised $53.3M, a drop of 75.8 pc from last week - YourStory

Pet Care Startup Wiggles Raises $1 Mn, Will Expand Its Footprint – Inc42 Media

Wiggles provides pet-focused products across India via partnerships with ecommerce companies

With funds, Wiggles will strengthen its presence, distribution and expand its product range

Wiggles has witnessed 40% month on month growth since June 2019

Pune-based pet healthcare and wellness startup, Wiggles, on Thursday, has raised $1 Mn funding in its first funding round from a long list of angel investors, investing in their own personal capacity.

Among the angel investors, prominent ones included Nachikhet Deshpande, COO of L&T Infotech, Aparna Badkundri, director, Dell Computers, Dr Sachin Phadke, managing director of Vetbiochem India, Abhay Amrute, senior partner, IIFL Wealth Management Ltd, Satish Billakota, vice president, Europe Cognizant, and Rishi Tanduulwadkar, founder of Solo Stem Cell Clinic, among others.

Founded in 2018 by father-daughter duo of Anushka Iyer and Rajh V Iyer along with Venky Mahadevan, Wiggles provides pet-focused products across India via partnerships with ecommerce companies.

Besides selling its products online, Wiggles also provides vet on call and grooming services across Pune and Mumbai.

With its first round of funds, Wiggles will strengthen its presence, operations, distribution and expand its product range and introduce more products. Additionally, the company is also planning to increase its footprint and launch its services in Hyderabad and Udaipur.

Founder and CEO of Wiggles, Anushka Iyer said that the company has witnessed 40% month on month growth since June 2019 along with a 4x return on costs. Having started off our operations in a single city Pune, we have now expanded our presence to Mumbai. We are focused on creating a brand with PAN India presence, she added.

Moreover, in a press statement, the company said that it aims to introduce transparency associated with costs, medication, nutrition and wellness options across the pet industry.

Wiggles claims that the platforms flagship offering is the Wiggles Box which contains anti-parasitic medicines, nutritional products and essential vitamins for a pet, which is backed by personalised alerts through the companys app ensuring that the pets never misses their doses again.

Pet care technology has been gaining ground across the world and one dog walking startups, Wag, backed by SoftBank, has even managed to enter the unicorn league.

In India, the technology trend is picking up force with tech players operating in the pet industry. While, pet food is the major segment in India, capturing more than two-thirds of the market revenues, pet accessories, grooming and healthcare are also growing rapidly into urban markets.

Besides gaining market popularity, startups operating in this space have also been able to attract investors and bag a substantial amount of funding.

Last month, a Delhi-based pet care and products retailer, Heads Up For Tails, completed a $10 Mn Pre-Series A funding round. The investment was led by a group of family offices, HNIs and existing promoters.

Another pet care startup CoZo, in August 2019, was in talks with marquee investors Sequoia Capital and Matrix Partners for raising funds for its pet wellness service.

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Pet Care Startup Wiggles Raises $1 Mn, Will Expand Its Footprint - Inc42 Media

New NCCN Guidelines Debut to Manage Complications and Improve Readiness for Stem Cell Transplant Recipients – Yahoo Finance

National Comprehensive Cancer Network expands resources to meet growing utilization of cell-based cancer treatments

PLYMOUTH MEETING, Pa., Oct. 30, 2019 /PRNewswire/ --Today, the National Comprehensive Cancer Network (NCCN ) published new NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ) for Hematopoietic Cell Transplantation (HCT), also known as stem cell transplant or historically as bone marrow transplant. This new resource provides step-by-step information on best practices in evaluating patients for hematopoietic cell transplantation and managing complications afterwards. This type of specialized treatment is increasingly common, occurring approximately 22,000 times a year in the United States in people with various malignancies, most commonly for blood-related cancers.1

NCCN Logo (C)NCCN(R) 2018. All rights reserved.

"Establishing NCCN Guidelines for Hematopoietic Cell Transplantation is a key accomplishment in the management of blood cancers," said Ayman A. Saad, MD, Professor of Clinical Medicine, The Ohio State University Comprehensive Cancer Center James Cancer Hospital and Solove Research Institute, Chair of the NCCN Guidelines Panel for HCT. "The current version of the guidelines addresses both pre-transplant evaluation and the management of a common complication: graft versus host disease (GVHD). Given the diversity of practice and expertise, we believe these guidelines will provide a pivotal tool for learning about the continuously updated therapy landscape in HCT. We hope this will help streamline clinical practices and educate new generations of physicians-in-training."

The guidelines provide recommendations on how to evaluate a potential transplant recipient to determine if the patient is an appropriate candidate for the procedure, and how to best manage different manifestations of post-transplant GVHD. They reflect the latest evidence and consensus from foremost experts across the 28 leading academic cancer centers that comprise NCCN, including hematologists/oncologists, transplant-specific practitioners, and infectious disease specialists.

"These guidelines provide an algorithmic pathway for a systematic approach to allogeneic (donor) transplantation across several different cancer types including leukemia, lymphoma, and multiple myeloma," explained Marcos de Lima, MD, Professor of Medicine, Case Comprehensive Cancer Center and University Hospitals of Cleveland , Vice-Chair of the NCCN Guidelines Panel for HCT. "Thankfully, the number of blood and bone marrow donors has increased substantially in just the past decade. When you combine the National Marrow Donor Program registry adult donors with cord blood donors and relatives (matched and mismatched), we are now able to perform this potentially cancer-curing procedure on significantly more patients than we could in the past. That's why it's so important to set standards for preventing and treating common adverse events and infections."

"Early referral for consideration of HCT can be life-saving, so we strongly encourage all oncologists to take a look at these guidelines and refer any possible candidates to transplant centers for evaluation," said Alison W. Loren, MD, MSCE, Director, Blood & Marrow Transplant, Cell Therapy & Transplant Program, Abramson Cancer Center of the University of Pennsylvania , Member of the NCCN Guidelines Panel for HCT. "We also urge oncologists who may be caring for patients after HCT to familiarize themselves with the varied manifestations of GVHDa very common and significant post-transplant complicationand to consult with transplant providers to optimize their ongoing care. The guidelines explain how to diagnose and treat this condition in order to achieve the best possible outcomes."

Story continues

The NCCN Guidelines for Hematopoietic Cell Transplantation are available free-of-charge for non-commercial use at NCCN.org and via the recently improved Virtual Library of NCCN Guidelines App for smartphone and tablet. NCCN will continue expanding blood cancer resources through continuous updates to the HCT guidelines, along with upcoming new NCCN Guidelines for Histiocytosis, Myeloid/Lymphoid Neoplasms, Pediatric B-Cell Lymphomas, and Pediatric Hodgkin Lymphoma.

About the National Comprehensive Cancer NetworkThe National Comprehensive Cancer Network (NCCN) is a not-for-profit alliance of 28 leading cancer centers devoted to patient care, research, and education. NCCN is dedicated to improving and facilitating quality, effective, efficient, and accessible cancer care so patients can live better lives. Through the leadership and expertise of clinical professionals at NCCN Member Institutions, NCCN develops resources that present valuable information to the numerous stakeholders in the health care delivery system. By defining and advancing high-quality cancer care, NCCN promotes the importance of continuous quality improvement and recognizes the significance of creating clinical practice guidelines appropriate for use by patients, clinicians, and other health care decision-makers around the world.

The NCCN Member Institutions are: Abramson Cancer Center at the University of Pennsylvania, Philadelphia, PA; Fred & Pamela Buffett Cancer Center, Omaha, NE; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute, Cleveland, OH; City of Hope National Medical Center, Duarte, CA; Dana-Farber/Brigham and Women's Cancer Center | Massachusetts General Hospital Cancer Center, Boston, MA; Duke Cancer Institute, Durham, NC; Fox Chase Cancer Center, Philadelphia, PA; Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance, Seattle, WA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL; Mayo Clinic Cancer Center, Phoenix/Scottsdale, AZ, Jacksonville, FL, and Rochester, MN; Memorial Sloan Kettering Cancer Center, New York, NY; Moffitt Cancer Center, Tampa, FL; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH; O'Neal Comprehensive Cancer Center at UAB, Birmingham, AL; Roswell Park Comprehensive Cancer Center, Buffalo, NY; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center, Memphis, TN; Stanford Cancer Institute, Stanford, CA; UC San Diego Moores Cancer Center, La Jolla, CA; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA; University of Colorado Cancer Center, Aurora, CO; University of Michigan Rogel Cancer Center, Ann Arbor, MI; The University of Texas MD Anderson Cancer Center, Houston, TX; University of Wisconsin Carbone Cancer Center, Madison, WI; Vanderbilt-Ingram Cancer Center, Nashville, TN; and Yale Cancer Center/Smilow Cancer Hospital, New Haven, CT.

Clinicians, visit NCCN.org. Patients and caregivers, visit NCCN.org/patients. Media, visit NCCN.org/news. Follow NCCN on Twitter @NCCN, Facebook @NCCNorg, and Instagram @NCCNorg.

1 D'Souza A, Fretham C. Current Uses and Outcomes of Hematopoietic Cell Transplantation (HCT): CIBMTR Summary Slides. 2018. Available at: https://www.cibmtr.org/ReferenceCenter/SlidesReports/SummarySlides/pages/index.aspx.

Media Contact: Rachel Darwin 267-622-6624 darwin@nccn.org

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New NCCN Guidelines Debut to Manage Complications and Improve Readiness for Stem Cell Transplant Recipients - Yahoo Finance

Stem Cell Research and Hair Transplants How Far Have We Come? – Science Times

(Photo : Stem cell research and hair transplants how far have we come?)

We all know that hair loss is a major problem, particularly for men around the world. While men who have enough hair left can have hair transplant procedures such as the FUT, FUE or DHI, done, this is not always possible.

It is always a smart move to consult with a hair loss specialist regardless of your situation because they may still be able to suggest something if you still have some hair. Only the specialist can tell assess what your situation is and what options are available. You can, for example, always contact a specialist at the Vera Clinic in Turkey to get evaluated.

In fact, men who are already very bald and have lost most of the hair found in the donor areas such as the back of the head may be out of luck when it comes to being able to have transplant surgery. This is a reason that scientists have been conducting experiments using stem cells. Some types of stem cells can be used to regenerate other types of cells and tissues in the body, so it is only natural that the idea came about to use stem cells to grow new hair follicles.

Stem cell research

There is often a lot of controversy regarding stem cell research because many people, including politicians, think that only human fetuses have stem cells and thus they argue that it is an unethical area of research. However, everybody has stem cells, not just fetuses, and it is a person's own stem cells that hold the potential to make new tissues. This is also partly why PRP therapy has been so successful, because the plasma actually contains many stem cells which trigger growth and repair of tissues.

Researchers have been able to grow some human hair follicles in the laboratory using stem cells. These same hairs were then transplanted into a mouse. Human testing cannot begin until animal testing is completed and many countries have rigorous processes in place when it comes to scientific investigations in humans.

This means that we can expect it to be some time yet before any human trials can take place using stem cells and hair transplants from follicles that are grown in the lab. The other problem which the scientists have noted is that it is more complicated than it seems since even though hair was transplanted into the mice, the outcome was not good and the hair was found to grow at odd angles. This could have been because it was a transplant between different species, but the reality is that hair transplantation is not as simple as it seem.

Stem cells may, however, be the last chance for people who have lost most of their hair. Scientists think that autologous hair transplants based on growing hair from a person's own stem cells may be something that becomes a reality in the future. At the moment, more studies need to be undertaken and the best advice is to seek treatment for hair loss before it reaches a point where nothing can be done.

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Stem Cell Research and Hair Transplants How Far Have We Come? - Science Times

Animal Stem Cell Therapy Market Sales Overview, Market Size, Opportunities, Demands, Market Share and Growth Analysis 2017 2025 – Health News Office

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Animal Stem Cell Therapy Market Sales Overview, Market Size, Opportunities, Demands, Market Share and Growth Analysis 2017 2025 - Health News Office