Biohack Your Way To Beauty And Health Using Your DNA And Stem Cells At These Wellness Retreats Around The World – Singapore Tatler

(Image: Four Seasons) By Chloe Pek October 11, 2019

Need a different type of getaway? From DNA and blood testing to harvesting your own stem cells, these facilities might make you want to forgo your usual spa retreats

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With so many resorts offering customised retreats tailored to every individual, today's well-travelled spa-goers are no longer satisfied with one-size-fits-all programmes. But beyond personalising activities and treatments to your fitness goals, these destinations are taking bespoke programmes to the next levelones that look into your genetic makeup and medical health to "biohack" your way to beauty and wellness.

(Related: The Tatler 10: Asia's Top Wellness Retreats)

Surrounded by the tropical rainforest in Nusa Dua, south Bali, Revivo Wellness Resort is an intimate retreat that offers 16 Balinese-style suites within three villas. The resort offers a regular schedule of three-day immersive programmes depending on individual goals, from relaxation to weight loss, as well as bespoke retreat programmes. And if you would like to take the personalisation to the next level, Revivo offers three DNA-centric plans that you can add to your programme.

In collaboration with DNA test provider GenePlanet, the Nutrifit and Nutrifit Premium plans offer individually tailored nutritional advice and lifestyle plans, based on your unique DNA makeup. Youll also return with a comprehensive report with analysis from up to 58 different DNA tests to facilitate your wellness goals. Beauty junkies can opt for the Nutriskin plan, which advises on skincare rituals, cosmetics, and diets to achieve optimum skin health.

revivoresorts.com

Surrounded by tropical gardens and white-sand beaches on Mexicos beautiful Riviera Nayarit, the newly renovated Four Seasons Resort Punta Mita offers guest rooms and suites, as well as private beach-front retreats for travellers. Besides a breathtaking oceanside golf-course, the resort also boasts the award-winning Apuane Spa, offering everything from signature massages to holistic therapies.

It is also the only spa in Four Seasons collection that offers DNA testing. Based on results from a simple cheek swab, wellness curators at the resort will create a custom programme that is tailored to your fitness goals and optimal for your genetic makeup, with recommendations to improve your health and diet.

fourseasons.com

(Related: 5 Women's Only Retreats For The Solo Female Traveller)

A preventive health and anti-ageing clinic in Switzerland, Nescens Clinique de Genolier is a luxury destination for medical tourists, overlooking Lake Geneva and the Alps. Programmes include La Cure Nescens, targetted at weight loss; Better-Aging Program which targets lifestyle issues like weight loss, fitness, detox and stress through spa treatments; and the new Nescens Stem Cell Advanced Program, which harnesses your own stem cells to combat signs of ageing.

The programme comprises a very in-depth check-up that includes physical examination, laboratory tests, diagnostic imaging, and cardiology to detect any underlying conditions. Then, following medical consultations with the specialists, a plastic surgeon will extract lipid content via liposuction. Your own stem cells are then separated and re-injected into problem areas together with lipofilling and hydrating mask treatments, to stimulate collagen production and reduce fine lines and wrinkles.

nescens.com

Tucked in a secluded cove by the Caribbean sea, BodyHoliday Saint Lucia is an all-inclusive fitness and spa resort that offers an extensive collection of wellness amenities, including an Ayurvedic temple, wellness centre, freshwater pools, fitness studios, as well as a BodyScience Clinic.

The clinics BodyScience Plus programme offers an in-depth analysis that begins prior to your arrival, requiring guests to complete an online health survey, DNA tests, and other diagnostics recommended by the clinics doctors, such as blood and urine tests. When you arrive, you will receive a personalised plan that will include Ayurvedic meals, a schedule of activities such as yoga, personal training or meditating, and also spa treatments. The programmes are specific to various wellness goals such as digestive health, weight loss, detox, destress and more.

thebodyholiday.com

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Biohack Your Way To Beauty And Health Using Your DNA And Stem Cells At These Wellness Retreats Around The World - Singapore Tatler

Man with at least 17 children sues fertility clinic for being ‘incredibly irresponsible’ with his sperm – Genetic Literacy Project

An Oregon doctor filed a $5.25 million lawsuit [October 2] against a fertility clinic at the Oregon Health & Science University for being incredibly irresponsible with his sperm.

Dr. Bryce Cleary, 53, alleges that the OHSU clinic used his 1989 sperm donation to father at least 17 childrensome who live in his areadespite him making an agreement with the clinic at the time that his sperm would be used for no more than five children, all born to women living out of the state.

Dr. Cleary, who lives in Corvallis, learned that at least two of his unexpected biological children conceived through the clinic have attended the same schools, as well as church and social activities, as some of the children he has with his wife.

The idea that you can produce that many children from one donor and throw them all in the same region? Cleary said inan emotional statement at a news conference. There has got to be some reforms.

In his lawsuit, filed in Multnomah County Circuit Court, Cleary says he is profoundly distressed and is grappling with the moral, legal, ethical, and personal obligations to his many children.

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Man with at least 17 children sues fertility clinic for being 'incredibly irresponsible' with his sperm - Genetic Literacy Project

I donated my embryos years ago. Now I’m friends with the mom who received them – Yahoo Lifestyle

In 2005 I donated embryos, and nine months later, the fertility clinic kindly informed me that the transfer had taken, and a twin girl and boy were born. I felt grateful for the news. In 2013 I heard from the clinic again, this time informing me of two new updates.

1. A third child was born in 2009. (Theyd forgotten to send the news at the time.)2. The recipient was satisfied that her family was complete, and rather than donating the eggs to stem cell science as is customary, she wanted to know if I wanted my cryogenically preserved embryos back.

Beyond the wondrous surprise of the email, the thoughtfulness of a stranger quietly holding this possibility for me felt like a cosmic miracle. I was touched by the idea of the potential children that might be born of these embryos one unlikely day, but more than that, I was moved by this anonymous persons generosity and grace. I instantly felt a deep connection when we began corresponding through a website for anonymous donors and recipients.

When the mother and I first started emailing each other, I was thrilled by the chance to connect with this person and exchange stories, which she was so utterly generous with. I made a point of taking my cues from her, never pushing for any information, and mostly listening. This woman had been so thoughtful about me, all these years, while I had no idea. Possibly, this is why our communication brought instant honesty. Once the embryos were transferred back to me, the mother wrote kindly about wanting to tell me that, thanks to details revealed in my donor profile and picturesmainly my devotion to writing, my deep gayness, and my look of short messy hair, tortoiseshell glasses, cuffed jeans, and a popped collarshe already had a deep sense of me.

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The mother and I entered into a consistent correspondence, and more than once she shared with me her gratitude for what she called this immaculate coupling that has created three perfect beingshealthy, loving, smart, their unborn siblings sure to follow suit. She expressed joy at being able to help another woman (me!) work on her career, unfettered by any biological imperative to raise children within a particular timeline. Then she opened up about the twins, a boy and a girl, and the youngest, a girl, a sibling configuration very similar to my own family.

In another email she shared a story with me about going to a yard sale with the three kids. Her stories gave me the sense that the girl and her twin both were a bit androgynous, and the younger sister was described as a quiet, pensive tomboyjust like my own sister. I laughed to myself, thinking that maybe queerness was genetic and all the cryobabies would be queer. When this problematic idea crossed my mind, I smiled at the intersection of biology and identity and some kind of science fiction-level genetic technology that I dont really understand beyond how it feels to have gone through the donation process, medically and emotionally, and how much wonder I feel in the face of the connection born between us. The mother also recounted a story of the girl twin heading straight to the section of boys clothes, where for $10 she amassed an entire back-to-school wardrobe embodying, the boyish, preppy look of Shiloh Jolie-Pitt crossed with KD Lang, to add a more tasteful flair. The mother wrote about being secretly proud, a feeling I experienced reading her secondhand account.

A few months into our pen-pal relationship, our conversations about turned more precisely to gender, trans identity, and the nuanced fluidity of the child self, uncontainable within ideological notions of gender, imposed through words and systems far too restrictive for a child. I learned the girl twin had started playing around with different pronouns at age three, eventually settling on she, and living out her own exact aesthetic and social selves under the loving watch of her utterly attentive mother.

When the mother asked about my own experiences with gender, I sent her links to Psychology Today blogs I had written about this very topic. Quickly she responded, My first reaction to your literary contributions is that Im proud of you, before going on to marvel that, I never thought in a million years that your writing would become my future child-rearing material.

From all the anecdotes and details she shared with me, I had a clear mental image of all three children, and an automatic, indescribable sense of identification with the one child in particular. Through our communications about this childs gender, the mother and I were able to connect on a level I can only describe as spiritual.

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I felt the call of these stories wishing to be told by our genes, and I continue to feel it in every cell in my body, despite having no specific words to share with this child and her siblings. Of all the anecdotes and images shared with me, here is the one that breaks me open every time I remember the early email where I learned details about the girl twin.And here I am, the mother had written, on the cusp of offering to reveal my life and giving a part of myself to someone Ive never met but I have. She is with us every day, her smile, her quirkiness, her drive, her cropped hair and Clark Kent glasses, her confusion, her revelations and rebirths, I have met her.

Reading this, I wiped the tears fogging up my Clark Kent glasses, my reflection glancing back at me in the glow of the screenmy cropped hair, my popped collar, my entire sense of self at once affirmed and exploded.

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I donated my embryos years ago. Now I'm friends with the mom who received them - Yahoo Lifestyle

Senior, caregivers conference and expo coming Oct. 11 – The Daily Courier

Seniors and caregivers are invited to the Senior & Caregivers Conference & Expo from 10 a.m. to 3 p.m. Friday, Oct. 11. at Liberty Traditional School, 3300 N. Lake Valley Road, Prescott Valley. This free event is sponsored by the Senior Connection, whose goal is to connect seniors and family caregivers with providers of products, services and support they may need.

The purpose of the Conference & Expo is to provide one central location where the public can learn about issues facing them in their role as a senior or caregiver, and speak with representatives from local companies that may be of help.

Presentations by local experts will occur on the hour, starting at 10 a.m., on some of the most important issues related to the challenges of being a senior or caregiver. The schedule is as follows: 10 a.m. Surviving Todays Healthcare System How to Become Your Own Advocate with Bonnie Shimko Arizona Care Management Solutions; 11 a.m. Loneliness The Silent Epidemic with Sam Downing, MD; noon Stem Cell Therapy New Hope or Snake Oil? with Wayne Bennett, DC Bennett Clinic; 1 p.m. Legal Issues for Caregivers with Chip McLaughlin Law Offices of Chester McLaughlin, P.C.; 2 p.m. Finding Hope Through Hospice with Kelly Paradis, Good Samaritan Society Hospice.

In addition to the presentations, attendees will have the opportunity to speak with representatives from approximately 60 local senior resource providers who will have information booths with literature about their products and services. Exhibitors represent a wide range of local resources, including in-home care assistance, independent and assisted living options, hospice care, legal and financial help, and health and fitness.

Debbie Stewart, CEO of Senior Connection says, There are a lot of resources available locally. However, it can be difficult to know where to begin and how to find them. Oftentimes, we dont even know what questions to ask. Dont wait until youre in the midst of a crisis to find out what help is available. Our message to Seniors and Family Caregivers is You are not alone help is available!

Attendees may stay for all or part of the day, as their schedule allows. RSVPs are not necessary.

For more information about the Senior Connection, including the online resource directory and Caregiver Connection newsletter, visit http://www.SeniorConnection.us or call 928-778-3747.

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Senior, caregivers conference and expo coming Oct. 11 - The Daily Courier

Stem cell research is a good thing | Opinion – Chart

Stem cell research is becoming more of a taboo topic as many people of the United States move into a seemingly more anti-abortion stance.

Stem cells come from a fetus that is between three to five days old (the clump of cells is called a blastocyst at this point) and can be used to reverse the effects of chemotherapy, and help repair damaged muscle.

According to the Mayo Clinic, stem cell research and transplants can also replace neurons damaged by any spinal cord injustices, improve the symptoms of Alzheimers and Parkinsons, and produce insulin to help people with diabetes. Adult stem cells can be used as well, but they are not as useful and can only be used to work with certain types of tissues, unlike the cells of a fetus which are more malleable.

According to the California Institute for Regenerative Medicine, the cells from these fetuses are donated with full consent from the donors and are from cells that were created by in vitro fertilization at various medical research clinics. Stem cells can also be collected from the placenta of a new born baby.

Stem cell research is viewed by a lot of people as the destruction of a human fetus, and that could not be farther from the truth. At three to five days old, a fetus is just a clump of cells.

It has no distinct characteristics other than it is made from the same cells as humans are. Many people think that it is unethical because these cells are possible humans, and instead of being used to create life, it is used for something completely different.

Lets say that we cut off all funding for research having to do with stem cells, including medical procedures using stem cells to repair parts of the body. This would prohibit many people from getting their bodies back to normal after receiving intense chemotherapy treatment, or due to being affected by a neurological disease.

The benefits of this type of research helps so many people that it would be ridiculous to choose a clump of cells over helping people who have been on this earth, making a difference in their own ways. It is inhumane to pick something so small, over helping a human obtain better quality of life.

It is understandable why people would be so against this, but the pros far outweigh the cons. It is an amazing scientific discovery that scientists can take new, healthy cells, and use them to repair damage.

The people against it should stop and think about how many lives can be changed or possibly saved in the future with more testing being done. It is amazing that scientists have even found out that it was possible to use cells to repair parts of the body that have been damaged.

Just imagine what kind of scientific discoveries scientists will be able to make in 10 years from now that could completely change our lives. It all starts with discoveries like this.

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Stem cell research is a good thing | Opinion - Chart

Regenerative medicine today: Are diabetes and vascular disease treatments ready for the clinic? – Science Magazine

Regenerative medicinewhich involves regrowing damaged or dysfunctional cells, tissues, and organs, in order to treat and cure human diseaseholds great promise. Discoveries in stem cell research and tissue engineering as well as advances in regulatory and industry support have brought regenerative medicine treatments closer than ever to the clinic. Two areas showing particular potential are diabetes and vascular disease. Whether acquired or congenital, diabetes afflicts millions of people worldwide and presents a tremendous burden both in terms of physical deterioration and loss of economic capacity. Current treatments rely mainly on lifetime injections of exogenous hormones and palliative treatments with pharmaceuticals, neither of which can address the lack of properly functioning beta cells in the pancreas. Similarly, vascular diseases are among the leading causes of mortality and morbidity. The ability to generate new, clinical-grade vascular tissue is critical to the long-term treatment of complications arising from ischemic injury, stroke, aneurisms, retinopathy, and other acute and chronic vascular conditions; significant progress has been made in using stem cell sources to produce this tissue. But what is needed to get such potentially transformative treatments over the finish line?

During this webinar, the speakers will:

This webinar will last for approximately 60 minutes.

University of Miami Miller School of MedicineMiami, FL

Juan Domnguez-Bendala, Ph.D., is director of the Stem Cell Development for Translational Research and research associate professor of surgery at the Diabetes Research Institute (DRI), University of Miami Miller School of Medicine. Before joining the DRI faculty, he worked at the Roslin Institute (Scotland, United Kingdom) under the supervision of one of the creators of Dolly the sheep. He obtained his Ph.D. there and acquired considerable experience in embryonic stem cell research and state-of-the-art genetic engineering techniques. Working with other DRI faculty and international collaborators, Dr. Domnguez-Bendala is currently involved in several projects that focus on the use of stem cells to obtain pancreatic islets that could be safely and efficiently transplanted into patients with type 1 diabetes. He is also working on new methods for the endogenous regeneration of pancreatic beta cells.

Mayo ClinicRochester, MN

As deputy director of Translation for the Center for Regenerative Medicine, medical director of the Advanced Product Incubator, and director of the Van Cleve Cardiac Regenerative Medicine Program at the Mayo Clinic in Rochester, Minnesota, Dr. Behfar has worked to establish off-the-shelf good manufacturing practice (GMP)-grade regenerative technologies. Over the last two decades, his program has engaged in evaluating cell-based technologies for restoration of skeletal and cardiac muscle function. During this time, he initiated clinical trials in heart failure along with Dr. Andre Terzic, using stem cells to restore cardiac function and treating over 400 patients. Through that experience, it was discovered that exosome secretion was the primary driver of the regenerative action of stem cells. More specifically, an exosome product was purified (termed purified exosome product, or PEP) from our regenerative platform that revealed massive biopotency in activating regeneration through mitogenic, antioxidant, anti-inflammatory and provasculogenic influence. This discovery now serves as the basis for many preclinical and clinical efforts at Mayo Clinic.

Science/AAASWashington, D.C.

Dr. Oberst did her undergraduate training at the University of Maryland, College Park, and her Ph.D. in Tumor Biology at Georgetown University, Washington D.C. She combined her interests in science and writing by pursuing an M.A. in Journalism from the Philip Merrill College of Journalism at the University of Maryland, College Park. Dr. Oberst joined Science/AAAS in 2016 as the Assistant Editor for Custom Publishing. Before then she worked at Nature magazine, the Howard Hughes Medical Institute, The Endocrine Society, and the National Institutes of Mental Health.

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Regenerative medicine today: Are diabetes and vascular disease treatments ready for the clinic? - Science Magazine

Dr Naveen Pemmaraju Outlines the Symptoms of Myelofibrosis – AJMC.com Managed Markets Network

Myelofibrosis has a very heterogeneous disease presentation, which means patients with it can present to the clinic with a number of different symptoms, explained Naveen Pemmaraju, MD, associate professor in the Department of Leukemia at MD Anderson Cancer Center.

Myelofibrosis has a very heterogeneous disease presentation, which means patients with it can present to the clinic with a number of different symptoms, explained Naveen Pemmaraju, MD, associate professor in the Department of Leukemia at MD Anderson Cancer Center.

Transcript

What does the myelofibrosis patient population look like? How do they present with symptoms?

So, patients with myelofibrosis (MF) in 2019, we know a lot more than we did 10 years ago. The most important aspect of the patient presenting into the clinic is to think about the performance status and MPN, or myeloproliferative neoplasm symptom burden. Its a heterogeneous disease presentation, which means that patients with patients with MF can present in a number of different ways.

On the lower-risk end, by the International prognostics scoring system, patients may actually be more like a chronic disease presentation, such as essential thrombocytosis and polycythemia vera. And the life expectancy may be measured in decades. But as you move into the intermediate to high risk, patients with MF can actually present quite ill to the clinic, large organomegaly hepatosplenomegaly, cachexia, weight loss, night sweats, fevers, and they can either present very sick or become ill quite quickly just from the disease itself. So, you have a wide range of patients with myelofibrosis.

The second aspect is the way were scoring the prognosis continues to exponentially increase. Theres so many scoring systems out there, but the bottom line is trying to capture the patients clinical presentation, including their age, their cytogenetics, and their molecular markers to try to come up with whos low risk, intermediate-high risk, who would benefit from a stem cell transplant, who would not, and then trying to figure out clinical trials and targeted therapies.

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Dr Naveen Pemmaraju Outlines the Symptoms of Myelofibrosis - AJMC.com Managed Markets Network

Businesses Sponsor Another Season Of Movies In The Park Square – Osprey Observer

Local residents are invited to do something a little different with their Saturday nights this fall. Businesses in FishHawk Ranchs Park Square are coordinating the Movies in the Park series for the second year with fun new attractions for the whole family.

The series, which kicked off last month with Aladdin, is coordinated by Eric Soncrant, owner of the Art Monkey Emporium.

Our goal is [to] provide fun things for families to do in Park Square, said Soncrant. We want Park Square to be active with our communitys families.

Voting is currently underway for the first October movie, which will take place on October 5. The options are The Secret Life of Pets 2, Avengers: End Game, Pokemon: Detective Pikachu and Shazam.

Our first movie had bear hugs where kids could make their own stuffed animals, and theyll be back for more events throughout the year, said Soncrant. We are working on some other surprises as well.

On October 19, Park Square will welcome local band Smakk for a concert, and two other concerts will take place during the series with a Winterfest event scheduled for November 30. All movies are free to everyone and will be shown on a 19-foot inflatable movie screen starting at dusk.

Come out at 6 p.m. to visit with our sponsors and order dinner, drinks and dessert from Park Square businesses, said Soncrant. We couldnt do this without the generosity of all of our sponsors, so please support them so we can keep building these events and provide more free fun in Park Square.

The events featured sponsor is the Tony Baroni Team at Keller Williams Realty and the starring sponsors are Watts Dental and Motion Chirotherapy. Other sponsors include Certified Roofers, Tampa Printer, LadyBird Academy FishHawk, Davenports Daily Delights, Briggs Family Insurance Services Amerifirst, Brandon Sports and Aquatic Center, Foundation Title and Trust, TECO Energy, Brandon Stem Cell Clinic and the Law Office of Kari L. McDonald.

For more information, call the Art Money Emporium at 315-9803. Visit Art Monkeys Facebook page to learn more and vote on upcoming movies. Park Square is located at 16132 Churchview Dr. in Lithia.

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Businesses Sponsor Another Season Of Movies In The Park Square - Osprey Observer

Stem Cell Manufacturing | Research Report Overview By Top Key Players, Opportunities, Key Drivers, Application and Regional Outlook To 2027 -…

(MENAFN - iCrowdNewsWire) Oct 4, 2019

Stem Cell Manufacturing MarketReport Provides Future Development Possibilities By Key Players , Key Drivers, Competitive Analysis, Scope, Key Challenges Analysis. The Reports Conjointly Elaborate The Expansion Rate Of The Industry Supported The Highest CAGR And Global Analysis. This Report Providing An In Depth And Top To Bottom Analysis By Market Size, Growth Forecast By Applications, Sales, Size, Types And Competitors For The Creating Segment And The Developing Section Among The Stem Cell Manufacturing Market. Market Expansion Worldwide With Top Players Future Business Scope And Investment Analysis Report

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MARKET INTRODUCTION

Stem cell manufacturing discusses the required technologies that enable the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic environment as therapeutics, while concurrently achieving control, reproducibility, automation, validation, and safety of the process and the product.

The market of stem cell manufacturing is anticipated to grow with a significant rate in the coming years, owing to the factors such as, growing public-private investments and funding in stem cell-based research, rising public awareness regarding the therapeutic potency of stem cell products, development of advanced genomic analysis techniques for quality control during stem cell manufacturing, technological advancements in stem cell manufacturing and preservation, and evolving regulatory frameworks for stem cell therapeutics.

The report also includes the profiles of key stem cell manufacturing companies along with their SWOT analysis and market strategies. In addition, the report focuses on leading industry players with information such as company profiles, products and services offered, financial information of last 3 years, key development in past five years.

Key Competitors In Market are Merck KGaA, Thermo Fisher Scientific, Inc., BD, Bio-Rad Laboratories, Inc., Miltenyi Biotec, Pharmicell Co., Ltd, Takara Bio Inc., STEMCELL Technologies Inc., Osiris Therapeutics, Inc., and NuVasive, Inc. among others.

TOC points of Market Report:

Market size & shares

Market trends and dynamics

Market Drivers and Opportunities

Competitive landscape

Supply and demand

Technological inventions in industry

Marketing Channel Development Trend

Market Positioning

Pricing Strategy

Brand Strategy

Target Client

MARKET SCOPE

The "Global Stem cell manufacturing Market Analysis to 2027" is a specialized and in-depth study of the biotechnology industry with a focus on the global market trend. The report aims to provide an overview of global stem cell manufacturing market with detailed market segmentation by of product, application and end user. The global stem cell manufacturing market is expected to witness high growth during the forecast period. The report provides key statistics on the market status of the leading market players and offers key trends and opportunities in the market. On the other hand, increasing market focus on embryonic stem cells and induced pluripotent stem cells are expected to offer new growth platforms to conduct advanced research and developments for the players in the global stem cell manufacturing market.

Market segmentation:

By Product (Stem Cell Lines, Instruments, Culture Media, And Consumables)

Application (Research Applications, Clinical Applications, and Cell and Tissue Banking)

End User (Pharmaceutical and Biotechnology Companies, Hospitals and Surgical Centers, Academic Institutes, Research Laboratories, and Cros, Cell Banks, and Tissue Banks)

By Geography North America, Europe, Asia-Pacific (APAC), Middle East and Africa (MEA) and South & Central America. And 13 countries globally along with current trend and opportunities prevailing in the region.

The target audience for the report on the market

Manufactures

Market analysts

Senior executives

Business development managers

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R & D staff

Distributors

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Governments

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MENAFN0410201900703403ID1099086064

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Stem Cell Manufacturing | Research Report Overview By Top Key Players, Opportunities, Key Drivers, Application and Regional Outlook To 2027 -...

Sigilon Therapeutics approaches the clinic – Vantage

The haemophilia A programme SIG-001, which has orphan drug status, leads the companys pipeline for rare diseases.Mr Vivaldi has form when it comes to haemophilia: he was formerly chief commercial officer atSpark, one of the groups developing a gene therapy for the disorder and a takeover target of Roche.

Haemophilia A, in which patients cannot produce clotting factor VIII, is the subject of intense gene therapy research, by companies including Biomarin, Sangamo and Spark. Clinical progress was initially highly promising, but long-term effectiveness remains to be proven (Two more patients bolster Sangamos haemophilia A gene therapy, July 6, 2019).

Mr Vivaldi says Sigilons technology could have several advantages over gene therapy, even if these projects do make it through the clinic to market. Haemophilia gene therapies tend to be unsuitable for children, liver or kidney disease patients, or those with pre-existing antibodies to viral vectors. This could exclude up to 80% of patients, he says.

Gene therapies cannot be re-dosed if their efficacy starts to wane; Mr Vivaldi says that patients can be re-treated with SIG-001 if necessary or have some spheres removed if the dose is too high.

The most important potential advantage is cost. Gene therapies are hugely expensive and no satisfactory payment model has so far been worked out. SIG-001is off-the-shelf and,according to Mr Vivaldi, easily scalable and more cost-effective.

Ofcourse this is all academic until SIG-001 justifies itself in human trials.He explains that the studies will be essentially the same as those for haemophilia A gene therapies, with endpoints including factor VIII levels, bleeding rates and quality of life measures. Data could appear by the end of next year or beginning of 2021.

Diabetes

The other main area of the groups research is diabetes. The timing of clinical trials here is under wraps for now owing to the collaboration agreement Sigilon has with Lilly. In April 2018 Lilly paid $63m up front and made what Mr Vivaldi calls a small equity investment in Sigilon. Milestones of up to $410m and high single-digit royalties on worldwide sales are also part of the package.

The cells are intended to provide a functional cure for type 1 diabetes a condition with which Mr Vivaldi himself lives.This is the same goal being chased by Semma Therapeutics, which was bought by Vertex this month and whose projects are also still preclinical (Vertex spends nearly $1bn on Semmas unproven diabetes cell tech, September 3, 2019). Two other companies, Viacyte and Sernova, have posted very early human data.

The central problem with implanted cell therapies is that unshielded cells have tended to work, but prompted an immune response, whereas encapsulated ones are non-immunogenic but have limited efficacy. Mr Vivaldi believes that Sigilons platform can overcome this, but proof is still some way away.

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Sigilon Therapeutics approaches the clinic - Vantage