Experts dispute doctor’s stem cell breakthrough claim …

By David Fitzpatrick and Drew Griffin CNN Special Investigations Unit

SANTIAGO, Dominican Republic (CNN) -- This Caribbean city already known for cigars, furniture, chocolate and coffee may become a magnet for Americans seeking controversial stem cell therapy for life-threatening illnesses if a Florida cardiologist has his way.

Dr. Zannos Grekos, a Florida cardiologist, says he's had success with stem-cell therapy in the Dominican Republic.

The Food and Drug Administration has not approved this stem cell therapy in the United States because no clinical trials to prove its effectiveness have been done. But Dr. Zannos Grekos says his company, Regenocyte Therapeutic, has successfully used adult stem cells to treat patients with heart and lung disease.

Grekos said he and his associates draw blood from a patient in Florida and then send it to a laboratory in Israel that produces what his company calls "regenocytes." The company defines regenocyte as "a stem cell that has been activated to become a target organ."

"These procedures work," he told CNN, standing inside a hospital room at the Clinica Union Medica del Norte in Santiago. "And it's substantiated by objective data that we are collecting."

But Grekos' procedures have not been reviewed by other researchers, and leading scientists involved in U.S. stem cell research efforts say Grekos is simply wrong. Dr. Irving Weissman, president-elect of the International Society for Stem Cell Research, told CNN, "There is no such cell. There is nothing called a 'regenocyte.' "

"As a stem cell scientist who works in the field of regenerative stem cells, I am disappointed and shocked that somebody would prey on a family that has an untreatable disease with the promise of a therapy that has no scientific or medical basis," Weissman said.

Grekos has a busy practice in Bonita Springs, Florida, outside Naples, and runs a company that promotes and administers stem cell therapies in Santiago, a noisy, crowded industrial city in the central Dominican Republic.

He told CNN that in the past 18 months, about 100 patients have received adult stem cell therapy at a Dominican hospital. Most of them have been patients with severe heart disease, while the rest have suffered from chronic lung illnesses, he said.

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Nationally Recognized Beverly Hills Orthopedic Surgeon, Dr. Raj, Now Offering Stem Cell Procedures to Help Patients …

Beverly Hills, California (PRWEB) August 11, 2014

Nationally recognized Beverly Hills orthopedic surgeon, Dr. Raj, is now offering stem cell procedures to help patients avoid the need for surgery. This may include joint replacement along with tendon or ligament surgery. For more information on stem cell therapy and scheduling at the Beverly Hills Orthopedic Institute, call (310) 247-0466.

As the benefit of stem cells for repair and regeneration of human tissue has evolved, the opportunity to avoid surgery has too. This includes those with cartilage degeneration, tendonitis and ligament injury. Dr. Raj has been a pioneer in bringing stem cell therapies to the forefront, and is now offering the procedures to all patients.

According to Celebrity Fitness Expert Dr. Raj, a nationally recognized Double Board Certified Orthopedic Surgeon at the Beverly Hills Orthopedic Institute, stem cell injections are being used to heal conditions that used to require surgery. Dr. Raj has been featured on The Doctors, SPIKE TV, NBC, CBS, Martha Stewart Living Radio, Beverly Hills Times and has been named Best of LA by KCAL 9 as well we making Americas Top Orthopedics List in 2007, 2009, 2010, and 2011.

Dr. Raj explains that stem cells have started a medical revolution and have altered the way doctors approach treatment. Stem cells help to regenerate the damaged cartilage within a joint and allow patients to take a more conservative route, adds Dr. Raj. Surgery should be a last case scenario after all other options have been exhausted.

For those individuals suffering from joint arthritis of the hip, knee, shoulder or ankle, surgery is an elective decision with nonsurgical options that traditionally did not alter the course of arthritis. They have merely acted as a "band aid" for pain relief, but not effective at long term relief due to healing arthritis.

Stem cell therapy offers the opportunity for relief and increased activity, while staying out of the operating room. The procedures are outpatient and safe, with minimal risks involved.

For more information on the stem cell procedures provided with the top orthopedic doctor in Los Angeles and Beverly Hills, call (310) 247-0466.

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Nationally Recognized Beverly Hills Orthopedic Surgeon, Dr. Raj, Now Offering Stem Cell Procedures to Help Patients ...

Stem cell stroke therapy shows promise after first human trial

A pilot study undertaken by researchers from Imperial College Healthcare NHS Trust and Imperial College London has shown promise in rapid treatment of serious strokes. The study, the first of its kind published in the UK, treated patients using stem cells from bone marrow.

Imagine a perfectly ordinary beginning to your day, say burned toast, no matching pair of socks and the usual damp commute to work. Except at some point through the usual minutiae you suffer a massive stroke. If you dont die outright, you may soon afterwards. Even supposing you survive those first days or weeks, the chance of your life resuming its comforting tedium is impossibly remote. You may need assistance for the rest of your shortened life.

According to the Stroke Association, about 152,000 people suffer a stroke in the UK alone each year. However, the five patients treated in the recent Imperial College pilot study all showed improvements. According to doctors, four of those had suffered the most severe kind of stroke, which leaves only four percent of people alive or able to live independently six months after the event. All four of the patients were alive after six months.

A particular set of CD34+ stem cells was used, as they help with the production of blood cells and blood vessels lining cells. These same cells have been found to improve the effects of stroke in animals, and they assist in brain tissue and blood growth in the affected areas of the brain. The CD34+ cells were isolated from samples taken from patients bone marrow and then infused into the affected area via an artery that leads to the brain, using keyhole surgery.

The innovative stem cell treatment differs from others in one important way: patients are treated within seven days of their stroke, rather than six months hence. The stroke sufferers all recorded improvements in terms of clinical measures of disability, despite four of the five having suffered the most severe kind of stroke.

It's still early days for the research, and much more will need to be done to expand clinical trials, but eventually it is hoped that a drug may be developed that can be administered to stroke sufferers as soon as they are admitted to hospital. This could ameliorate longer term effects and allow for speedier recovery and a faster entry into therapy.

A paper detailing the research was published in journal Stem Cells Translational Medicine.

Source: Imperial College London

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Stem cell stroke therapy shows promise after first human trial

Hope for future treatment of thousands of stroke sufferers from stem cells

"So we said what about the other 90 per cent?"

The team targeted patients who had suffered massive strokes involving a blood clot in the blood vessel in the middle of the brain. Typically there is a high mortality rate in these patients and those who survive are often severely disabled, are unable to walk, talk, feed or dress themselves.

The experimental procedure was carried out on five patients aged between 40 and 70, all of whom showed improvement over the following six months and three were living independently.

More than 152,000 people suffer a stroke in England per year and the research team said that the new procedure could eventually help most of them.

Dr Madina Kara, a neuroscientist at The Stroke Association, said: Previous studies have shown that a type of stem cell, called CD34+ cells, shows promise to aid stroke recovery. These latest results suggest that this type of treatment could be administered safely and were looking forward to seeing the outcomes of further studies to see exactly how they are aiding recovery.

This is one of the most exciting recent developments in stroke research; however, its still early days in stem cell research but the findings could lead to new treatments for stroke patients in the future.

"In the UK, someone has a stroke every three and half minutes, and around 58 per cenrt of stroke survivors are left with a disability.

"One of the few existing treatments which can limit brain damage caused by stroke is thrombolysis. However, this drug can only be used to treat strokes caused by blood clots and must be administered within the first 4.5 hours after a stroke. There is an urgent need for alternative treatments to help prevent the debilitating impact of stroke."

The experimental procedure involves several stages, first the patient's own bone marrow is harvested, which was then sent to a specialist laboratory so the specific stem cells, called CD34+ can be selected.

Then the patient undergoes a procedure in which a wire is inserted into a vein in the neck and up into the area of brain damage. Once there the stem cells are released and the wire retracted.

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Hope for future treatment of thousands of stroke sufferers from stem cells

Hope for stroke victims after radical stem cell treatment enables patients to move and talk again

5 stroke victims were treated with stem cells extracted from bone marrow Treatment triggers rapid regeneration of damaged brain cells Patients regained power of speech and use of their arms and legs More than 150,000 people have a stroke in England every year Treatment is at early stage and needs years of testing Imperial College London scientists says it shows 'great potential'

By Ben Spencer

Published: 09:25 EST, 8 August 2014 | Updated: 19:30 EST, 8 August 2014

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Five people who had suffered severe strokes (illustrated) regained the power of speech and mobility thanks to a radical new treatment

Stroke patients have shown remarkable signs of recovery after they were given a radical new treatment.

Five people who had suffered severe strokes regained the power of speech, use of their arms and legs and improved cognition after just six months, according to British research published today.

The three men and two women, aged between 45 and 75, were treated with stem cells extracted from their own bone marrow in the first experiment of its kind.

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Hope for stroke victims after radical stem cell treatment enables patients to move and talk again

Japanese researcher's death highlights problems in dealing with scientific misconduct

10 hours ago by Michael Eisen, The Conversation Yoshiki Sasai was a leading stem-cell scientist in Japan. Credit: EPA

In 1987, my father, a scientist at the US National Institute of Health, killed himself after a member of his lab committed scientific fraud and he got caught up in the investigation. So I found the news that Yoshiki Sasai, a Japanese stem-cell scientist, had allegedly committed suicide in the wake of the STAP controversy deeply disturbing.

The STAP controversy began in January over two papers published in the journal Nature. In them, researchers claimed to have developed a simple method of creating embryonic-like stem cells, called STAP (or stimulus-triggered acquisition of pluripotency). The claim, if true, would have given stem-cell research a big boost. But, within months, problems with the papers were spotted and the researchers' institute deemed that the lead author Haruko Obokata was guilty of scientific misconduct.

Sasai, one of the leading stem-cell researchers in Japan, was a co-author on both the papers, which have now been retracted from Nature. He was, however, cleared of any charges of misconduct.

Neither was my father involved in fraud. But as one of the senior scientists on the research project, my father bore the brunt of institutional criticism. And he seemed to have been far more disturbed by it than the people who were found guilty of the fraud.

It is hard for me not to place at least part of the blame for my father's death on the way the scientific community responds to scientific misconduct.

Obviously, fraud is a terrible thing. Nothing provides as deep an existential threat to the scientific enterprise than making up data. But as bad as it is, there is something deeply ugly about the way the scientific community responds to misconduct.

We need to deal swiftly with fraud when it is identified. But time after time I have watched not only the accused, but everyone around them, be treated with such sanctimonious disdain.

Imagine what it must be like to have devoted your life to science, and then to discover that someone in your midst someone you have some role in supervising has committed the ultimate scientific sin. That itself must be disturbing enough. Indeed I remember how upset my father was as he was trying to prove that fraud had taken place. But then imagine what it must feel like to all of a sudden become the focal point for scrutiny to experience your colleagues and your field casting you aside. It must feel like your whole world is collapsing around you, and not everybody has the mental strength to deal with that.

We are all so confident this could never happen to us, that it must be that somebody in a position of power was lax, or that the environment was flawed. It is there in the institutional response. And it is there in the whispers. I still remember how the faculty in my graduate department at the California Institute of Technology talked about David Baltimore when Thereza Imanishi-Kari, a researcher with whom Baltimore had published a paper in the journal Cell, was accused of scientific fraud. (Imanishi-Kari was eventually deemed not guilty.)

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Japanese researcher's death highlights problems in dealing with scientific misconduct

Embryonic Stem-Cell Research: Experts Debate Pros and Cons

Experts debate embryonic stem-cell research. What are the pros and cons? Is it necessary? Is it ethical? Get the facts and learn the issues from the experts themselves.

The positions couldnt be more polar.

Some say it could save lives. Others say it kills them. And the embryonic stem-cell research debate shows no signs of dying down any time soon.

We invited each participant to write an argument, then read the opponents argument and write a rebuttal. Neither was allowed to read the others initial argument before writing his own, and neither could read the others response before rebutting.

Opponents point out that research on adult stem cells has yielded more practical results so farfor example, bone marrow transplants. But proponents believe embryonic stem cells hold more promise. Besides, they say, research on adult stem cells has been going on longer than on embryonic ones.

In the end, whatever such cells may or may not be able to give us, the question comes down to: Is embryonic stem-cell research ethical? And thats what we asked our experts to debate.

Share your opinions in the comments section at the end of the article.

Human embryonic stem-cell research is not only ethical, it is an essential field to pursue to make key advances in biomedical research to treat diseases effectively where there are currently no curesincluding, but not limited to, paralysis from spinal cord injury, diabetes, Parkinsons disease and cancer.

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Embryonic Stem-Cell Research: Experts Debate Pros and Cons

Quebec womans leukemia battle highlights need for minority bone marrow and stem cell donors

MONTREALA Quebec womans desperate online plea for a compatible stem-cell donor in her bid to fight cancer a second time is shedding light on the lack of minorities on official lists in Canada and abroad.

Mai Duong finds herself battling leukemia again and doctors say they would like to proceed with a transplant of bone marrow or cord blood stem cells within a month.

But Duong, 34, has discovered that locating the right person can be a needle-in-a-haystack challenge, particularly for those who are from a non-Caucasian background.

This is a global problem, Duong, who is of Vietnamese origin, said in an interview from her room at Montreals Maisonneuve-Rosemont Hospital.

We cant do a scavenger hunt every time someone has this type of problem.

Duong, who returned home a few days after being interviewed, said a recent bone marrow biopsy showed no signs of cancer. She will now begin four weeks of maintenance chemotherapy, which is given in lower doses to assist in prolonging a remission.

The mother of a 4-year-old girl, Duong successfully fought off acute leukemia in 2013 with chemotherapy. She had to terminate a 15-week pregnancy to undergo the treatment. Duong was in remission until a blood test revealed leukemia had returned this past May.

Seventy per cent of people who had that type of leukemia were just cured with chemotherapy, and unfortunately Im in the 30 per cent, she said.

The diagnosis and a lack of a match in her family have touched off a mad scramble to find a fellow Vietnamese donor. An online campaign has taken that hunt global.

I have cancer, I had a relapse, I dont have a bone marrow (donor) these are things I cannot change, Duong said. So I said, what can I do about it?

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Quebec womans leukemia battle highlights need for minority bone marrow and stem cell donors

Early Stem Cell Transplant Vital in ‘Bubble Boy’ Disease …

By Amy Norton HealthDay Reporter

WEDNESDAY, July 30, 2014 (HealthDay News) -- Babies born with so-called "bubble boy" disease can often be cured with a stem cell transplant, regardless of the donor -- but early treatment is critical, a new study finds.

Severe combined immunodeficiency (SCID), as the condition is medically known, actually refers to a group of rare genetic disorders that all but eliminate the immune system. That leaves children at high risk of severe infections.

The term "bubble boy" became popular after a Texas boy with SCID lived in a plastic bubble to ward off infections. The boy, David Vetter, died in 1984 at the age of 12, after an unsuccessful bone marrow transplant -- an attempt to give him a functioning immune system.

Today, children with SCID have a high chance of survival if they receive an early stem cell transplant, researchers report in the July 31 issue of the New England Journal of Medicine.

In the best-case scenario, a child would get stem cells -- the blood-forming cells within bone marrow -- from a sibling who is a perfect match for certain immune-system genes.

But that's not always an option, partly because kids with SCID are often their parents' first child, said Dr. John Cunningham, director of hematopoietic stem cell transplantation at the University of Chicago Comer Children's Hospital. He was not involved in the study.

In those cases, doctors typically turn to a parent -- who is usually a "half" match, but whose stem cells can be purified to improve the odds of success. Sometimes, stem cells from an unrelated, genetically matched donor can be used.

The good news: Regardless of the donor, children with SCID can frequently be cured, according to the new findings. But early detection and treatment is vital.

"These findings show that if you do these transplants early -- before [the age of] 3.5 months, in a child without infection -- the results are really quite comparable to what you have with a matched sibling," said lead researcher Dr. Richard O'Reilly, chief of the pediatric bone marrow transplant service at Memorial Sloan-Kettering Cancer Center in New York City.

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Early Stem Cell Transplant Vital in 'Bubble Boy' Disease ...

Extracted fat put forward as cure for wobbly knees

Mary Ann Benitez

Thursday, July 31, 2014

Health Innovative Technology chief executive Matthew Fan Chun-yin said his company is banking on the fat graft's potential as a drug in future and acquired ProStemCell last year to expand its bio- bank storage and research capabilities.

The government plans to issue new rules and regulations governing stem cell laboratories, he said.

During a tour of the laboratories of HIT ProStemCell in Kowloon Bay, Fan said scientists discovered stem cells from the extracted fat stimulate the repair of the knee cartilage and relieves pain for osteoarthritic patients.

He said it was unfortunate that liposuction has been tarnished by the death of a dance teacher and studio owner Josephine Lee Ka-ying, 32, who fell comatose and died after a four-hour liposuction treatment at the Regrowth Hair Transplant Centre in Tsim Sha Tsui on June 27 this year.

"You should not do any liposuction in a non-qualified day surgery center," said Fan, a former dietician.

He said ProStemCell, which HIT acquired last year, built a "clean-room" laboratory four years ago which meets the US Food and Drug Administration's standards.

The classification is the same required of companies for drug manufacturing and for hospital operating theaters which do open-heart surgery.

ProStemCell built the laboratory because the administration put out guidelines in 2009 requiring such stringent laboratory guidelines.

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Extracted fat put forward as cure for wobbly knees