Category Archives: Stem Cell Doctors


How effective is PLX cell therapy in treating coronavirus? Experts answer all queries and more – India TV News

Pluristem Therapeutics or PLX cell therapyuses placentas to grow smart cells, and programs them to secrete therapeutic proteins in the bodies of sick people. It has just treated its first American COVID-19 patient after treating seven Israelis. The patients were suffering from acute respiratory failure and inflammatory complications associated with Covid-19. Now, this theraphy is being touted as a possible 'cure'' for the deadly coronavirus with scientisst conducting varied researches on the same. In an exclusive interaction with India TV, doctors from India and abroadcame together for discussing about how effective can cell therapy be in treating coronavirus. Dr Solomon from Israel, Dr Anil Kaul from the US, DrSanjeev Chaubey from Shanghai and Dr Padma Srivastv and Dr Harsh Mahajan from India threw light upon the stem cell therapy and the possibility of incorporating the same in treating COVID-19 pateints.

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How effective is PLX cell therapy in treating coronavirus? Experts answer all queries and more - India TV News

VIDEO: Is It Allergies or COVID-19? – HealthDay Live – HealthDay Coronavirus Liveblog

Regular exercise can potentially prevent life-threatening cases of COVID-19, according to a review from Zhen Yan, a top exercise researcher at the University of Virginia School of Medicine.

Cardiovascular exercise increases the production of an antioxidant called extracellular superoxide dismutase (EcSOD). Yan compiled a comprehensive review of existing research to find that increased levels of this antioxidant protect the lungs from developing a severe complication associated with COVID-19, called acute respiratory distress syndrome (ARDS). Even a single session of exercise increases the production of this lung-protecting antioxidant.

Some cases of COVID-19 progress to the lungs and cause ARDS, a condition in which fluid collects in the lungs and deprives the body of oxygen. ARDS is a major cause of death in COVID-19 patients. Around 20% to 42% of patients hospitalized with the virus develop ARDS, and approximately 45% of those that develop severe cases of ARDS will die, according to the U.S. Center for Disease Control and Prevention and prior research.

Yan's review suggests that exercise can prevent or reduce the severity of ARDS, according to a press release about the project. "Regular exercise has far more health benefits than we know. The protection against this severe respiratory disease condition is just one of the many examples," said Yan. The findings were published in the journal Redox Biology.

Read the full press release.

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VIDEO: Is It Allergies or COVID-19? - HealthDay Live - HealthDay Coronavirus Liveblog

HealthDay Reports: More Good News on Remdesivir’s Power to Treat COVID-19 – HealthDay Coronavirus Liveblog

The U.S. Food and Drug Administration (FDA) authorized the first at-home sample collection test for COVID-19 today.

The FDA re-issued the emergency use authorization (EUA) for LabCorp's COVID-19 RT-PCR Test, which will now be permitted to test the at-home samples people take using LabCorp's Pixel by LabCorp COVID-19 Test home collection kit.

The at-home sample collection kit includes designated nasal swabs and saline. After someone takes a sample from their nose with the special nasal swab, they mail the sample inside of an insulated package to a LabCorp lab for testing.

According to a tweet from LabCorp, kits will initially be made available to frontline healthcare workers and first responders. Kits will be available to consumers in most states, with a doctor's order, in the coming weeks, according to the FDA release.

This authorization is only for the LabCorp COVID-19 RT-PCR Test for at-home collection of nasal swab specimens using the Pixel by LabCorp COVID-19 home collection kit. This is not a general authorization for at-home COVID-19 sample collection tests.

Read the full press release.

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HealthDay Reports: More Good News on Remdesivir's Power to Treat COVID-19 - HealthDay Coronavirus Liveblog

‘Stem cell therapy more effective on Covid-19’ – Korea Biomedical Review

I dont know why people pay attention only to vaccines and treatments against the new coronavirus. Stem cell therapies are more useful to treat Covid-19.

So claimed Lee Hee-young, president of the Korean Association of Stemcell Therapy, at a news conference in Seoul, Monday. He called for active use of stem cell therapies to treat Covid-19 patients.

Several studies have proved the effects of autologous stem cells in treating acute respiratory distress syndrome (ARDS), which is the leading cause of death in Covid-19 patients, Lee said. The concept of stem cell therapy is the same as that of blood transfusion or bone marrow transplantation. Decades of cell therapies have proved that stem cell therapy is safe.

While the development of a treatment or a vaccine against Covid-19 takes a long time and it may not be able to treat patients immediately because of virus mutation possibilities, stem cell therapies can restore damaged lungs directly, Lee claimed.

It is more important to restore damaged lungs than to fight the virus. Stem cell therapy restores the lungs, giving patients time to beat the virus, he went on to say. However, people are paying attention to vaccine or treatment candidates only. This is why I am holding a news conference.

Lee pointed out that the local environment makes it difficult to use stem cell therapies. Thus, the government should ease regulations on the management and use of cell culture facilities so that doctors can perform stem cell therapies with simple cell culture, he said.

As long as physicians have a positive pressure facility and a culture kit, they can separate and culture cells with simple training, he said. If the authorities allow doctors to perform stem cell therapies with a disposable mobile culture autonomously, the cost of stem cell therapies will go down significantly.

Lee added that he asked related officials to include such rules in the Act on Safety and Support for Advanced Regenerative Medicine and Advanced Biopharmaceuticals, which is to take effect in the second half of the year.

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'Stem cell therapy more effective on Covid-19' - Korea Biomedical Review

Planned Clinical Trial of Allogeneic Stem Cell Therapy Remestemcel-L in Patients with COVID-19 – Cancer Network

Mount Sinai Health System announced that they will be using remestemcel-L (Ryoncil), an innovative allogeneic stem cell therapy, in patients with coronavirus disease 2019 (COVID-19).

Additionally, Mount Sinai indicated that they will play a central role in a clinical trial for patients with severe acute respiratory distress syndrome, which affects individuals with severe cases of COVID-19.

Remestemcel-L has previously been tested in patients who have had a bone marrow transplant, who can experience an overactive immune response similar to that observed in severe cases of COVID-19.

Mount Sinai began administering remestemcel-L to patients in late March under the FDAs compassionate use program. The therapy was given to 10 patients with moderate to severe cases of COVID-19-related acute respiratory distress syndrome (ARDS), most of whom were on ventilators, and the doctors saw encouraging results.

We are encouraged by what we have seen so far and look forward to participating in the randomized controlled trial starting soon that would better indicate whether this is an effective therapy for patients in severe respiratory distress from COVID-19, Keren Osman, MD, medical director of the Cellular Therapy Service in the Bone Marrow and Stem Cell Transplantation Program at The Tisch Cancer Institute at Mount Sinai and associate professor of Hematology and Medical Oncology at the Icahn School of Medicine at Mount Sinai, said in a press release.

The randomized clinical trial evaluating the therapeutic benefit and safety of remestemcel-L will be conducted at Mount Sinai, which will serve as the clinical and data coordinating center. The stem cell therapy will be evaluated in 240 patients with COVID-19-related ARDS in the US and Canada. Moreover, the trial will be conducted as a public-private partnership between the Cardiothoracic Surgical Trials Network.

The coronavirus pandemic has caused exponential increases of people suffering with acute respiratory distress syndrome, requiring intubation and mechanical ventilation with many dying, Annetine Gelijns, PhD, the Edmond A. Guggenheim Professor of Health Policy at the Icahn School of Medicine at Mount Sinai, said in a press release. We have designed a clinical trial that will expeditiously determine whether the stem cell therapy will offer a life-saving therapy for a group of patients with a dismal prognosis.

Remestemcel-L consists of mesenchymal stem cells. The therapy was previously assessed in a phase III trial in children who had graft-versus-host disease (GVHD), which can occur after bone marrow transplants. Further, the inflammation that occurs in GVHD is the result of a cytokine storm. A similar cytokine storm has been found to take place in patients with COVID-19 who develop acute respiratory distress syndrome.

These stem cells have shown excellent response rates in severe graft-versus-host disease in children, John Levine, MD, professor of Hematology, Medical Oncology, and Pediatrics at the Icahn School of Medicine at Mount Sinai, who is also the co-director of the Mount Sinai Acute GVHD International Consortium (MAGIC), said in a press release. Mesenchymal stem cells have a natural property that dampens excessive immune responses.

Some institutions have also begun testing anti-IL-6 agents, such as tocilizumab (Actemra), for the treatment of cytokine release syndrome in patients with COVID-19 who develop acute respiratory distress syndrome.

Reference:

Mount Sinai Leading the Way in Innovative Stem Cell Therapy for COVID-19 Patients [news release]. New York, NY. Published April 9, 2020. newswise.com/coronavirus/mount-sinai-leading-the-way-in-innovative-stem-cell-therapy-for-covid-19-patients/?article_id=729684&sc=dwhr&xy=10019792. Accessed April 15, 2020.

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Planned Clinical Trial of Allogeneic Stem Cell Therapy Remestemcel-L in Patients with COVID-19 - Cancer Network

What are the underlying conditions causing more serious illness from coronavirus? – KSBW The Central Coast

We've heard that elderly people and those with underlying health conditions are most at risk if they're infected with coronavirus, but those can seem like really general terms. Who does that include? And why can they face more serious illness?"According to the , some of the underlying conditions that may put you at higher risk include: chronic lung disease and asthma, heart disease and undergoing cancer treatment," said CNN Chief Medical Correspondent Dr. Sanjay Gupta. Anyone with diabetes, kidney failure or liver failure may also be at higher risk.The role of the immune system is to protect against disease or other potentially damaging pathogens. A strong one is needed to help stave off coronavirus infection."Think of it like this," Dr. Gupta suggested. "In your everyday life, you're always fighting off pathogens. Most of the time you don't even realize it. If you have an underlying condition, it makes it more challenging to fight off a virus like this. You may develop a fever, shortness of breath or a cough more easily than someone who doesn't have a preexisting illness."Additionally, there are more specific reasons why each condition has its own vulnerabilities. Here's a guide to underlying conditions affected by coronavirus and why, and how you can protect yourself or an at-risk loved one.Older adultsEight out of 10 deaths reported in the U.S. have been in adults ages 65 and older, according to the CDC. Older adults have also been more likely to require hospitalization and admission to an intensive care unit.Older adults are more likely to have long-term health problems that can increase their risk for infection and serious disease. And, our immune systems usually weaken with age, making it more difficult for people to fight off infections, according to Johns Hopkins Medicine.The quality of our lung tissue also declines over time, becoming more elastic and making respiratory diseases such as COVID-19 of important concern because of the potential for lung damage.Inflammation in older adults can be more intense, leading to organ damage.Those with lung disease, asthma or heart conditionsPeople with chronic airway and lung diseases such as chronic obstructive pulmonary disease, asthma, pulmonary fibrosis and interstitial lung disease can lay the foundations for more severe infection with coronavirus because of the inflammation, scarring and lung damage those conditions cause, Johns Hopkins Medicine reported.COVID-19 affects a person's airway and lungs, but those organs work together to provide the body with oxygen. When the lungs are overburdened with an infection, the heart has to work harder, which exacerbates the challenges of people already living with heart disease.The immunocompromisedAccording to the CDC, many conditions can cause a person to be immunocompromised, including cancer treatment, smoking, bone marrow or organ transplantation and immune deficiencies. Poorly controlled HIV or AIDS and prolonged use of man-made steroid hormones or other immune-weakening medications can also hamper a person's immune function.Cancer can weaken immunity by spreading into the bone marrow, which makes blood cells that help fight infection, according to Cancer Research UK. Cancer prevents bone marrow from making enough blood cells.Some cancer treatments can temporarily weaken the immune system, too. Because cancer treatments such as chemotherapy, cancer drugs, radiotherapy or steroids are targeted toward cancer cells, they can also diminish the number of white blood cells created in the bone marrow.A 2017 study found cigarette smoking can harm the immune system by either causing extreme immune responses to pathogens or rendering the body less effective at fighting disease. This may occur by smoking, negatively altering the cellular and molecular mechanisms responsible for keeping an immune system strong.When a person undergoes a bone marrow transplant using stem cells from a donor, or they receive an organ, a doctor may prescribe medications to prevent graft-versus-host disease and mitigate the immune system's reaction by suppressing its function. After the operation, it takes time for your immune system to be up and running again.HIV and AIDS attack the body's immune system, specifically the body's T cells, which help the immune system fight off infection. When the diseases are untreated, HIV reduces the number of those cells, making the person more likely to contract other infections or infection-related cancer, according to the CDC.Severe obesityPeople with severe obesity, or a body mass index of 40 or higher, are at higher risk of serious disease."Obesity shares with most chronic diseases the presence of an inflammatory component," a 2012 study said. Inflammatory responses were linked between the immune system and body fat. Obesity is known to impair immune function by altering white blood cell count as well as the cells that control immune responses.DiabetesPeople with type 1 or type 2 diabetes face an increased risk of getting really sick with COVID-19, as both cause a blood sugar spike. If blood sugar is poorly managed, viral diseases can be more dangerous as high blood sugar may give viruses a place to thrive, according to Diabetes in Control, a news and information resource for medical professionals.Higher levels of inflammation have been discovered in the bodies of people with diabetes, weakening the immune system and making it more difficult for those affected to stave off sickness in general.Kidney and liver diseaseThe kidneys produce several hormones that affect immune responses. Having kidney disease and failure can weaken your immune system, making it easier for infections to take hold. According to the National Kidney Foundation, doctors and researchers have found that most infections are worse in people with kidney disease.The liver is an integral member of the body's line of defense, helping to regulate the number of white blood cells utilized in immune responses and defend against harmful pathogens. Someone with liver disease is experiencing abnormalities in the function of the immune system, giving rise to more serious illness.Neurodevelopmental conditionsNeurological and neurodevelopmental conditions may also increase the risk of serious COVID-19 for people of any age.These include disorders of the brain, spinal cord, peripheral nerve and muscle such as cerebral palsy, epilepsy, stroke and intellectual disability, according to the CDC. Those with moderate to severe developmental delay, muscular dystrophy or spinal cord injury are also more at-risk.People with neurological conditions may not be more at risk due to solely their condition, but because medications they might take to control their condition could hamper their immune system. However, some neurological conditions, such as Parkinson's, have been recognized to have inflammatory components, which may harm the immune system.Others including muscular dystrophy, multiple sclerosis or amyotrophic lateral sclerosis (ALS) could cause paralysis to the diaphragm, which leaves those affected very at risk for respiratory failure if they were to be sick with COVID-19.Staying safe when you're more at riskIf you see yourself on the list of those at higher risk for severe illness, there are several things you can do to protect yourself. First, make sure you are contact your doctor or doctors about your risk level. Second, be extra vigilant about the recommendations that most people are being asked to follow.Stay home whenever possible and avoid close contact with people, the CDC suggests. Wash your hands often to prevent transferring the virus from a surface to your face, and try to clean and disinfect frequently touched surfaces as often as you can.If you don't have an underlying condition, doing your part by practicing these cautionary measures can help protect not only you, but your loved ones with existing conditions.

We've heard that elderly people and those with underlying health conditions are most at risk if they're infected with coronavirus, but those can seem like really general terms. Who does that include? And why can they face more serious illness?

"According to the [Centers for Disease Control and Prevention], some of the underlying conditions that may put you at higher risk include: chronic lung disease and asthma, heart disease and undergoing cancer treatment," said CNN Chief Medical Correspondent Dr. Sanjay Gupta. Anyone with diabetes, kidney failure or liver failure may also be at higher risk.

The role of the immune system is to protect against disease or other potentially damaging pathogens. A strong one is needed to help stave off coronavirus infection.

"Think of it like this," Dr. Gupta suggested. "In your everyday life, you're always fighting off pathogens. Most of the time you don't even realize it. If you have an underlying condition, it makes it more challenging to fight off a virus like this. You may develop a fever, shortness of breath or a cough more easily than someone who doesn't have a preexisting illness."

Additionally, there are more specific reasons why each condition has its own vulnerabilities. Here's a guide to underlying conditions affected by coronavirus and why, and how you can protect yourself or an at-risk loved one.

Eight out of 10 deaths reported in the U.S. have been in adults ages 65 and older, according to the CDC. Older adults have also been more likely to require hospitalization and admission to an intensive care unit.

Older adults are more likely to have long-term health problems that can increase their risk for infection and serious disease. And, our immune systems usually weaken with age, making it more difficult for people to fight off infections, according to Johns Hopkins Medicine.

The quality of our lung tissue also declines over time, becoming more elastic and making respiratory diseases such as COVID-19 of important concern because of the potential for lung damage.

Inflammation in older adults can be more intense, leading to organ damage.

People with chronic airway and lung diseases such as chronic obstructive pulmonary disease, asthma, pulmonary fibrosis and interstitial lung disease can lay the foundations for more severe infection with coronavirus because of the inflammation, scarring and lung damage those conditions cause, Johns Hopkins Medicine reported.

COVID-19 affects a person's airway and lungs, but those organs work together to provide the body with oxygen. When the lungs are overburdened with an infection, the heart has to work harder, which exacerbates the challenges of people already living with heart disease.

According to the CDC, many conditions can cause a person to be immunocompromised, including cancer treatment, smoking, bone marrow or organ transplantation and immune deficiencies. Poorly controlled HIV or AIDS and prolonged use of man-made steroid hormones or other immune-weakening medications can also hamper a person's immune function.

Cancer can weaken immunity by spreading into the bone marrow, which makes blood cells that help fight infection, according to Cancer Research UK. Cancer prevents bone marrow from making enough blood cells.

Some cancer treatments can temporarily weaken the immune system, too. Because cancer treatments such as chemotherapy, cancer drugs, radiotherapy or steroids are targeted toward cancer cells, they can also diminish the number of white blood cells created in the bone marrow.

A 2017 study found cigarette smoking can harm the immune system by either causing extreme immune responses to pathogens or rendering the body less effective at fighting disease. This may occur by smoking, negatively altering the cellular and molecular mechanisms responsible for keeping an immune system strong.

When a person undergoes a bone marrow transplant using stem cells from a donor, or they receive an organ, a doctor may prescribe medications to prevent graft-versus-host disease and mitigate the immune system's reaction by suppressing its function. After the operation, it takes time for your immune system to be up and running again.

HIV and AIDS attack the body's immune system, specifically the body's T cells, which help the immune system fight off infection. When the diseases are untreated, HIV reduces the number of those cells, making the person more likely to contract other infections or infection-related cancer, according to the CDC.

People with severe obesity, or a body mass index of 40 or higher, are at higher risk of serious disease.

"Obesity shares with most chronic diseases the presence of an inflammatory component," a 2012 study said. Inflammatory responses were linked between the immune system and body fat. Obesity is known to impair immune function by altering white blood cell count as well as the cells that control immune responses.

People with type 1 or type 2 diabetes face an increased risk of getting really sick with COVID-19, as both cause a blood sugar spike. If blood sugar is poorly managed, viral diseases can be more dangerous as high blood sugar may give viruses a place to thrive, according to Diabetes in Control, a news and information resource for medical professionals.

Higher levels of inflammation have been discovered in the bodies of people with diabetes, weakening the immune system and making it more difficult for those affected to stave off sickness in general.

The kidneys produce several hormones that affect immune responses. Having kidney disease and failure can weaken your immune system, making it easier for infections to take hold. According to the National Kidney Foundation, doctors and researchers have found that most infections are worse in people with kidney disease.

The liver is an integral member of the body's line of defense, helping to regulate the number of white blood cells utilized in immune responses and defend against harmful pathogens. Someone with liver disease is experiencing abnormalities in the function of the immune system, giving rise to more serious illness.

Neurological and neurodevelopmental conditions may also increase the risk of serious COVID-19 for people of any age.

These include disorders of the brain, spinal cord, peripheral nerve and muscle such as cerebral palsy, epilepsy, stroke and intellectual disability, according to the CDC. Those with moderate to severe developmental delay, muscular dystrophy or spinal cord injury are also more at-risk.

People with neurological conditions may not be more at risk due to solely their condition, but because medications they might take to control their condition could hamper their immune system. However, some neurological conditions, such as Parkinson's, have been recognized to have inflammatory components, which may harm the immune system.

Others including muscular dystrophy, multiple sclerosis or amyotrophic lateral sclerosis (ALS) could cause paralysis to the diaphragm, which leaves those affected very at risk for respiratory failure if they were to be sick with COVID-19.

If you see yourself on the list of those at higher risk for severe illness, there are several things you can do to protect yourself. First, make sure you are contact your doctor or doctors about your risk level. Second, be extra vigilant about the recommendations that most people are being asked to follow.

Stay home whenever possible and avoid close contact with people, the CDC suggests. Wash your hands often to prevent transferring the virus from a surface to your face, and try to clean and disinfect frequently touched surfaces as often as you can.

If you don't have an underlying condition, doing your part by practicing these cautionary measures can help protect not only you, but your loved ones with existing conditions.

See the original post here:
What are the underlying conditions causing more serious illness from coronavirus? - KSBW The Central Coast

What are the underlying conditions causing more serious illness from coronavirus? – WPBF West Palm Beach

We've heard that elderly people and those with underlying health conditions are most at risk if they're infected with coronavirus, but those can seem like really general terms. Who does that include? And why can they face more serious illness?"According to the , some of the underlying conditions that may put you at higher risk include: chronic lung disease and asthma, heart disease and undergoing cancer treatment," said CNN Chief Medical Correspondent Dr. Sanjay Gupta. Anyone with diabetes, kidney failure or liver failure may also be at higher risk.The role of the immune system is to protect against disease or other potentially damaging pathogens. A strong one is needed to help stave off coronavirus infection."Think of it like this," Dr. Gupta suggested. "In your everyday life, you're always fighting off pathogens. Most of the time you don't even realize it. If you have an underlying condition, it makes it more challenging to fight off a virus like this. You may develop a fever, shortness of breath or a cough more easily than someone who doesn't have a preexisting illness."Additionally, there are more specific reasons why each condition has its own vulnerabilities. Here's a guide to underlying conditions affected by coronavirus and why, and how you can protect yourself or an at-risk loved one.Older adultsEight out of 10 deaths reported in the U.S. have been in adults ages 65 and older, according to the CDC. Older adults have also been more likely to require hospitalization and admission to an intensive care unit.Older adults are more likely to have long-term health problems that can increase their risk for infection and serious disease. And, our immune systems usually weaken with age, making it more difficult for people to fight off infections, according to Johns Hopkins Medicine.The quality of our lung tissue also declines over time, becoming more elastic and making respiratory diseases such as COVID-19 of important concern because of the potential for lung damage.Inflammation in older adults can be more intense, leading to organ damage.Those with lung disease, asthma or heart conditionsPeople with chronic airway and lung diseases such as chronic obstructive pulmonary disease, asthma, pulmonary fibrosis and interstitial lung disease can lay the foundations for more severe infection with coronavirus because of the inflammation, scarring and lung damage those conditions cause, Johns Hopkins Medicine reported.COVID-19 affects a person's airway and lungs, but those organs work together to provide the body with oxygen. When the lungs are overburdened with an infection, the heart has to work harder, which exacerbates the challenges of people already living with heart disease.The immunocompromisedAccording to the CDC, many conditions can cause a person to be immunocompromised, including cancer treatment, smoking, bone marrow or organ transplantation and immune deficiencies. Poorly controlled HIV or AIDS and prolonged use of man-made steroid hormones or other immune-weakening medications can also hamper a person's immune function.Cancer can weaken immunity by spreading into the bone marrow, which makes blood cells that help fight infection, according to Cancer Research UK. Cancer prevents bone marrow from making enough blood cells.Some cancer treatments can temporarily weaken the immune system, too. Because cancer treatments such as chemotherapy, cancer drugs, radiotherapy or steroids are targeted toward cancer cells, they can also diminish the number of white blood cells created in the bone marrow.A 2017 study found cigarette smoking can harm the immune system by either causing extreme immune responses to pathogens or rendering the body less effective at fighting disease. This may occur by smoking, negatively altering the cellular and molecular mechanisms responsible for keeping an immune system strong.When a person undergoes a bone marrow transplant using stem cells from a donor, or they receive an organ, a doctor may prescribe medications to prevent graft-versus-host disease and mitigate the immune system's reaction by suppressing its function. After the operation, it takes time for your immune system to be up and running again.HIV and AIDS attack the body's immune system, specifically the body's T cells, which help the immune system fight off infection. When the diseases are untreated, HIV reduces the number of those cells, making the person more likely to contract other infections or infection-related cancer, according to the CDC.Severe obesityPeople with severe obesity, or a body mass index of 40 or higher, are at higher risk of serious disease."Obesity shares with most chronic diseases the presence of an inflammatory component," a 2012 study said. Inflammatory responses were linked between the immune system and body fat. Obesity is known to impair immune function by altering white blood cell count as well as the cells that control immune responses.DiabetesPeople with type 1 or type 2 diabetes face an increased risk of getting really sick with COVID-19, as both cause a blood sugar spike. If blood sugar is poorly managed, viral diseases can be more dangerous as high blood sugar may give viruses a place to thrive, according to Diabetes in Control, a news and information resource for medical professionals.Higher levels of inflammation have been discovered in the bodies of people with diabetes, weakening the immune system and making it more difficult for those affected to stave off sickness in general.Kidney and liver diseaseThe kidneys produce several hormones that affect immune responses. Having kidney disease and failure can weaken your immune system, making it easier for infections to take hold. According to the National Kidney Foundation, doctors and researchers have found that most infections are worse in people with kidney disease.The liver is an integral member of the body's line of defense, helping to regulate the number of white blood cells utilized in immune responses and defend against harmful pathogens. Someone with liver disease is experiencing abnormalities in the function of the immune system, giving rise to more serious illness.Neurodevelopmental conditionsNeurological and neurodevelopmental conditions may also increase the risk of serious COVID-19 for people of any age.These include disorders of the brain, spinal cord, peripheral nerve and muscle such as cerebral palsy, epilepsy, stroke and intellectual disability, according to the CDC. Those with moderate to severe developmental delay, muscular dystrophy or spinal cord injury are also more at-risk.People with neurological conditions may not be more at risk due to solely their condition, but because medications they might take to control their condition could hamper their immune system. However, some neurological conditions, such as Parkinson's, have been recognized to have inflammatory components, which may harm the immune system.Others including muscular dystrophy, multiple sclerosis or amyotrophic lateral sclerosis (ALS) could cause paralysis to the diaphragm, which leaves those affected very at risk for respiratory failure if they were to be sick with COVID-19.Staying safe when you're more at riskIf you see yourself on the list of those at higher risk for severe illness, there are several things you can do to protect yourself. First, make sure you are contact your doctor or doctors about your risk level. Second, be extra vigilant about the recommendations that most people are being asked to follow.Stay home whenever possible and avoid close contact with people, the CDC suggests. Wash your hands often to prevent transferring the virus from a surface to your face, and try to clean and disinfect frequently touched surfaces as often as you can.If you don't have an underlying condition, doing your part by practicing these cautionary measures can help protect not only you, but your loved ones with existing conditions.

We've heard that elderly people and those with underlying health conditions are most at risk if they're infected with coronavirus, but those can seem like really general terms. Who does that include? And why can they face more serious illness?

"According to the [Centers for Disease Control and Prevention], some of the underlying conditions that may put you at higher risk include: chronic lung disease and asthma, heart disease and undergoing cancer treatment," said CNN Chief Medical Correspondent Dr. Sanjay Gupta. Anyone with diabetes, kidney failure or liver failure may also be at higher risk.

The role of the immune system is to protect against disease or other potentially damaging pathogens. A strong one is needed to help stave off coronavirus infection.

"Think of it like this," Dr. Gupta suggested. "In your everyday life, you're always fighting off pathogens. Most of the time you don't even realize it. If you have an underlying condition, it makes it more challenging to fight off a virus like this. You may develop a fever, shortness of breath or a cough more easily than someone who doesn't have a preexisting illness."

Additionally, there are more specific reasons why each condition has its own vulnerabilities. Here's a guide to underlying conditions affected by coronavirus and why, and how you can protect yourself or an at-risk loved one.

Eight out of 10 deaths reported in the U.S. have been in adults ages 65 and older, according to the CDC. Older adults have also been more likely to require hospitalization and admission to an intensive care unit.

Older adults are more likely to have long-term health problems that can increase their risk for infection and serious disease. And, our immune systems usually weaken with age, making it more difficult for people to fight off infections, according to Johns Hopkins Medicine.

The quality of our lung tissue also declines over time, becoming more elastic and making respiratory diseases such as COVID-19 of important concern because of the potential for lung damage.

Inflammation in older adults can be more intense, leading to organ damage.

People with chronic airway and lung diseases such as chronic obstructive pulmonary disease, asthma, pulmonary fibrosis and interstitial lung disease can lay the foundations for more severe infection with coronavirus because of the inflammation, scarring and lung damage those conditions cause, Johns Hopkins Medicine reported.

COVID-19 affects a person's airway and lungs, but those organs work together to provide the body with oxygen. When the lungs are overburdened with an infection, the heart has to work harder, which exacerbates the challenges of people already living with heart disease.

According to the CDC, many conditions can cause a person to be immunocompromised, including cancer treatment, smoking, bone marrow or organ transplantation and immune deficiencies. Poorly controlled HIV or AIDS and prolonged use of man-made steroid hormones or other immune-weakening medications can also hamper a person's immune function.

Cancer can weaken immunity by spreading into the bone marrow, which makes blood cells that help fight infection, according to Cancer Research UK. Cancer prevents bone marrow from making enough blood cells.

Some cancer treatments can temporarily weaken the immune system, too. Because cancer treatments such as chemotherapy, cancer drugs, radiotherapy or steroids are targeted toward cancer cells, they can also diminish the number of white blood cells created in the bone marrow.

A 2017 study found cigarette smoking can harm the immune system by either causing extreme immune responses to pathogens or rendering the body less effective at fighting disease. This may occur by smoking, negatively altering the cellular and molecular mechanisms responsible for keeping an immune system strong.

When a person undergoes a bone marrow transplant using stem cells from a donor, or they receive an organ, a doctor may prescribe medications to prevent graft-versus-host disease and mitigate the immune system's reaction by suppressing its function. After the operation, it takes time for your immune system to be up and running again.

HIV and AIDS attack the body's immune system, specifically the body's T cells, which help the immune system fight off infection. When the diseases are untreated, HIV reduces the number of those cells, making the person more likely to contract other infections or infection-related cancer, according to the CDC.

People with severe obesity, or a body mass index of 40 or higher, are at higher risk of serious disease.

"Obesity shares with most chronic diseases the presence of an inflammatory component," a 2012 study said. Inflammatory responses were linked between the immune system and body fat. Obesity is known to impair immune function by altering white blood cell count as well as the cells that control immune responses.

People with type 1 or type 2 diabetes face an increased risk of getting really sick with COVID-19, as both cause a blood sugar spike. If blood sugar is poorly managed, viral diseases can be more dangerous as high blood sugar may give viruses a place to thrive, according to Diabetes in Control, a news and information resource for medical professionals.

Higher levels of inflammation have been discovered in the bodies of people with diabetes, weakening the immune system and making it more difficult for those affected to stave off sickness in general.

The kidneys produce several hormones that affect immune responses. Having kidney disease and failure can weaken your immune system, making it easier for infections to take hold. According to the National Kidney Foundation, doctors and researchers have found that most infections are worse in people with kidney disease.

The liver is an integral member of the body's line of defense, helping to regulate the number of white blood cells utilized in immune responses and defend against harmful pathogens. Someone with liver disease is experiencing abnormalities in the function of the immune system, giving rise to more serious illness.

Neurological and neurodevelopmental conditions may also increase the risk of serious COVID-19 for people of any age.

These include disorders of the brain, spinal cord, peripheral nerve and muscle such as cerebral palsy, epilepsy, stroke and intellectual disability, according to the CDC. Those with moderate to severe developmental delay, muscular dystrophy or spinal cord injury are also more at-risk.

People with neurological conditions may not be more at risk due to solely their condition, but because medications they might take to control their condition could hamper their immune system. However, some neurological conditions, such as Parkinson's, have been recognized to have inflammatory components, which may harm the immune system.

Others including muscular dystrophy, multiple sclerosis or amyotrophic lateral sclerosis (ALS) could cause paralysis to the diaphragm, which leaves those affected very at risk for respiratory failure if they were to be sick with COVID-19.

If you see yourself on the list of those at higher risk for severe illness, there are several things you can do to protect yourself. First, make sure you are contact your doctor or doctors about your risk level. Second, be extra vigilant about the recommendations that most people are being asked to follow.

Stay home whenever possible and avoid close contact with people, the CDC suggests. Wash your hands often to prevent transferring the virus from a surface to your face, and try to clean and disinfect frequently touched surfaces as often as you can.

If you don't have an underlying condition, doing your part by practicing these cautionary measures can help protect not only you, but your loved ones with existing conditions.

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What are the underlying conditions causing more serious illness from coronavirus? - WPBF West Palm Beach

Devoted coach, father and husband remembered for ‘bringing out the best’ in people throughout life – Elk Grove Citizen

By Kerensa Uyeta-Buckley

Sports Editor

In middle school, Justis Bowers (now Daigler) got pedicures with her friends to celebrate a birthday. Not only did her dad, Joe, take them to the salon, he sat right next to them and got a pedicure too.

When Joes son, J.C. Bowers, played basketball for Bradshaw Christian High School in his senior year, Joe was happy to coach his son.

Family meant everything to Joe, and when his wife, Melissa, coached Bradshaw Christians volleyball team to a Sac-Joaquin Section Championship in 2016, Joe, who was known to lead the fans in an occasional cheer during games, cried.

His playful, giving and loving nature defined Joe to those who spent time with him. That time he spent as a basketball coach, father, husband and friend was stunningly cut short on April 10, however, when he passed away after a lengthy battle with leukemia with Melissa by his side in San Francisco.

Joes re-emergence of cancer came out of nowhere, however. After a grim diagnosis over the summer, he had made nearly a complete turnaround and was on a careful but optimistic road to recovery.

In March, after three to four weeks of experiencing headaches, Joe went to the emergency room at UC Davis on March 28 after showing some numbness and not being able to talk fully.

Doctors discovered a bleed on his brain and he was released then went for a follow-up April 1 at University of California, San Francisco, where doctors discovered his cancer had returned full force and had spread into his brain and spinal fluid, Melissa Bowers said.

During his time in the hospital, the Bowers family Facetimed with Joe, with Justis in Fort Bragg, J.C. in Australia, and Melissa from home due to amped-up measures surrounding hospitals regarding COVID-19.

After three rounds of chemotherapy, on April 8, however, his doctor informed Melissa that the treatment wasnt working. Treatment was stopped, and Melissa drove from Sacramento to be with her husband immediately.

During a time where he could have focused on himself or thought negatively, instead the 67 former college basketball player and longtime high school coach turned his attention to something bigger, Melissa said.

At the end, Wednesday or Thursday night before he passed, I asked him, Joe, are you scared? Although he couldnt communicate very well, he had to struggle to talk, he said, No, Im not scared, I just want to make this about Christ, which was really huge for us. He wanted to encourage me, his students, (everyone); theres something bigger here and Gods up to something, Melissa said.

That faith, as well as his strength, were two traits that also had become familiar aspects of Joes nature to those who were in his life.

Joe could read me, and one of the best conversations Ive had with anybody was about a year and a half ago. He pulled me aside and just talked to me and gave me some words of encouragement. Next thing I know, we were talking for three hours till midnight, J.J. Mina, who played for Joe in high school and coached with him at Bradshaw Christian as well, said. He realized I was hurting.

Mina and current Pride varsity boys basketball head coach Alex Williams won the Sac-Joaquin Section Championship in 2009 as players at Bradshaw Christian under former head coach Mike Ruble, with Joe on the coaching staff as well.

The team went 12-1 in the Sac Metro League that year, and beat Forest Lake Christian for the Section Championship, 55-52.

This year, Mina, Williams and Bowers all coached another formidable Pride roster to the SJS title game as well as the semifinals of the CIF Nor Cal playoffs, which is further than any Pride team had reached in program history, Williams said.

It was equally hard for both of us, Williams said of himself and Mina when they found out Joe had passed away. I think what we were both saying was it was almost like God gave him another six months to have a victory lap, of sorts [after struggling in the summer of 2019 with both leukemia and a fungal infection before recovering]. I know Joe really enjoyed this past year of basketball.

Bowers was the Prides head coach before handing the team to Williams for the 2019-20 season so that the team could focus on basketball while he recovered. Last week, Williams informed the team through text and phone calls of his passing.

Ive had a lot of kids reach out to me and say he was a good man, Im going to miss him. Whether you really knew Joe that well or saw him in passing, he made an impact on people. Having him around, he taught me a lot as a coach. This was my first year as a head coach and having him be a part of that was pretty special.

Joe has always been the father type of coach and, of course, he knew the game of basketball like no other. He would do anything for anybody, Mina said. He was just a selfless person and when I say hed give you the shirt off his back, he would.

Never one to shy away from yelling while coaching a game if he had to, Joes experience with basketball was honed from his days playing in high school and at Sacramento City College, Cosumnes River College and Bethany College.

He coached at Capital Christian, which also turned out to be the site of the Prides last playoff game, from the late 90s to 2004 before moving on to other schools, including Bradshaw Christian.

He had a way of bringing out the best. Id say he brought out more, Melissa said of Joes coaching strategy.

One highlight in his personal life was walking Justis down the aisle at her April 2019 wedding three weeks after his stem cell transplant.

His impact on others families will be felt far beyond his own in the coming years, as Williams noted.

As I grow up, I just had a daughter, shes two months old, hes the kind of guy you look up to, Williams said of Joe. Those are the kinds of things you just look up to with a guy like that. He just possesses a lot of qualities that are hard to match.

Melissa said that, although the family cant hold the service it would have liked for Joe because of social distancing restrictions due to the novel coronavirus, shed like to hold one when she is able to, as soon as possible.

Our hope is that maybe in June or July we will have a celebration of life. In the meantime, were still making plans for family and how we want to do that. But I know that I want all these friends and family and also so many students to be able to say goodbye, said Melissa.

In that time, peers will be able to remember the man who once became a human ice cream sundae, had life-long friendships that reached as far back as second grade, and whod drop everything to be there for his family.

He never made excuses for anything. He didnt give you an excuse. He was always making people laugh, Mina said.

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Devoted coach, father and husband remembered for 'bringing out the best' in people throughout life - Elk Grove Citizen

Helping the helpers – The Jewish Standard

Not only is it all about community, but its the way that the community responds that shows us what the community is, and who we really are, Angelica Berrie says.

It also helps define leaders, she added.

Ms. Berrie, the philanthropist and activist, who lives in Englewood and among many other activities runs the Russell Berrie Foundation of Teaneck, has begun giving grants in response to the pandemic. These grants, the first wave in what will be at least three, shaped to fit the stage of the crisis, will go toward helping organizations meet their most immediate needs as they work with the most vulnerable populations.

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That first wave of grants gives $1.6 million locally and another $1 million to Israel.

Holy Name Medical Center in Teaneck is at the epicenter of the pandemic in New Jersey. Thats not a good place to be. Ms. Berrie has been supporting it not only with the $225,000 her foundation is giving for personal protective equipment and ventilators, but also by paying for food on a regular basis for staff, Holy Names president and chief executive officer, Michael Maron, said. She is helping us source PPE, equipment, and ventilators. She and her entire board are remarkable in that way.

Reflecting on the course of the pandemic so far, Mr. Maron sees some hope, but he cautions that nothing is clear yet. We have more inpatients than ever, but the rate of growth absolutely has slowed down, he said earlier this week. That might be because social distancing has begun to flatten the curve, as it was intended to do, but it might be an artefact of the calendar. Weve just gotten beyond Pesach and Easter, and often people who arent sure about whether they should go to the hospital hang on at home until those holy days are over.

Angelica Berrie and Mike Maron celebrated at the Holy Name gala. (JEFFREY RHODE, COURTESY OF HOLY NAME MEDICAL CENTER)

Were a little nervous about what might happen next, he said.

Holy Name, like many other hospitals, has made adjustments. We have expanded our capacity significantly, Mr. Maron said. We normally have 20 ICU beds, but now we have 120. We managed to build five units in two weeks. The big auditorium, Marian Hall, has been totally transformed into three critical care units.

We also took the top floor, where we had started construction, back when the world was normal, to expand our operating room. So we stopped the construction, and those crews built two 20-bed ICUs in that space. And when this is over, we will go back and expand our operating rooms.

Holy Name transformed its spaces to fit in more ICU beds. (JEFFREY RHODE, COURTESY OF HOLY NAME MEDICAL CENTER)

Well leave up the ICS in Marian Hall, though, for at least a year, because a lot of the models are predicting spikes and surges. So until we have either a vaccine or aggressive treatment, we will leave it in place.

Hes proud of how the ICUs have been built; its an innovative design, developed in house, that we encourage other health systems to come by and see, he said.

The engineering feat is that its all designed to keep patients in a negative pressure area, Mr. Maron said. The entire inside room is negative pressure. That means that it extracts the airflow out of the room at a very high volume. Any virus expelled in that space goes right up a vent, and through a high micron-capturing filter. The cleansed air is released outside, and the viruses stay trapped in the filter until they die. We will decontaminate the filters when all this is done, but the virus has a limited life span on inanimate objects, so it will die naturally, Mr. Maron said.

Covid-19 patients can FaceTime with their family and friends. (JEFFREY RHODE, COURTESY OF HOLY NAME MEDICAL CENTER)

The other nice part of it is that all these rooms have big windows, so most of the nursing care is done on the outside. Nurses can check IV pumps, ventilators, monitors, and all sorts of other high-tech medical equipment without having to get hazmat-suited to walk into the dangerous, virus-laden rooms. That deprives the patients of even more human contact, but because any human contact must be mediated through that bulky, feature-hiding protective gear, the effect is pretty similar to what the patients already experience.

Nurses and PPE are the two most critical resources, and theyre in short supply, Mr. Marans said. This allows us to preserve PPE, because we need to use less of it. It also saves time for the nursing staff, which they can use to watch over their patients; its slow work taking the gear on and off.

Much of Holy Names innovation comes from its close collaboration with Shaare Zedek Medical Center in Jerusalem. Our emergency room was totally rebuilt after 9/11, in cooperation with Shaare Zedek, Mr. Maron said. They gave us tremendous insight into how you would deal with the mass casualty events that Israel has to deal with all the time. That emergency room, built below ground because of Israels experience with bombings, is the space now turned into ICUs. It is very effective clinical care space, Mr. Maron said.

The collaboration that we have with Israel has paid back in spades, he continued. Because of Angelica and because of that relationship with Israel, we are beginning to use a stem-cell treatment that was developed in Israel to help fight covid-19.

Across the country, like here at Holy Name, staff members undertake quiet acts of heroism many times a day. (JEFFREY RHODE, COURTESY OF HOLY NAME MEDICAL CENTER)

Its placenta-harvested stem cells, called Pluristem, that boosts the immune system, and they give them to people with covid. Its relatively new, and we managed to get FDA approval; it took a week or two to get through the FDA approval process. As of this writing, one patient had gotten the treatment and two more were scheduled to receive it.

It helps boost the immune system, Mr. Maron said. Its for people who already are on ventilators. The cells themselves do not directly heal tissue, but they create an immune response that then contributes to enhancing the healing of the tissue thats already been damaged or swollen. It helps reduce inflammation and that helps heal the tissue.

Despite the hospitals greatly expanded capacity, it is far better for patients to be able to stay out of it, Mr. Maron said. We have successfully sent home patients who tested positive. We feel that with aggressive home telemonitoring, home is the best place to care for them.

So rather than admit people who have gone to the ER, been swabbed and tested here, we have nurse practitioners call them. Depending on the acuity of their level of illness, they call two to four times a day.

These are video calls, he said; everyone has at least a phone, if no other, larger screen. That has worked very effectively. Using video and telephone, one nurse can manage many more patients safely, and with more limited exposure. So were helping people get through these challenging times safely. Theyre at home, and theyre not alone.

Overall it has had a very big impact on helping people recover faster and better, and it keeps many more people safe and not exposed to the virus.

The nurses will put patients through breathing exercises and get them to be more mobile, Mr. Maron continued. Being sedentary is one of the worse things you can do, but the fatigue level is quite high. You have to take as many deep breaths as you can to keep your oxygen level up, and the only way you can do that is if someone is calling you and coaching you and pulling you through it. Otherwise, you will just curl up in bed and not want to move.

I can attest to that personally.

Mr. Maron got the virus. I am okay now, but it took me about two weeks, and I lost 20 pounds. My doctors here caution me, because when I give interviews Ive been saying that I had a mild case, but my primary care physician said, Mike, you lost 20 pounds. That alone tells me that it was not mild.

You do not want to get this disease. Listen to me. I can tell you firsthand. You really do not want to get covid.

In my lowest point, I was teetering on the edge of being admitted and having to go on a ventilator. That was a very scary moment. The mortality rate is just too high.

Dont fool yourself, Mr. Maron said. I was one of those people who never gets sick. I never get colds. I never get the flu. I dont think I called in sick out of work in 28 years. I was just one of those people. But this knocked me off my feet in a big way.

The superman mentality just doesnt work.

I have seen far too many young people in their 20s and 30s, who were otherwise fit and healthy, lose their lives. This disease does not discriminate. We do not know why some people succumb and others do not. But it can happen in hours. You can go from breathing on your own, just struggling a little bit, to having to be on a ventilator.

You have to take that seriously. You have to self-quarantine.

Mr. Maron commends the leaders of the Jewish community for being so quick to ask for self-quarantining, and so thorough and unyielding in their recommendations. The rabbis were way ahead of the curve, and they took a lot of heat for it, but we are seeing very positive results from it now. They should be applauded and thanked for their willingness to take the heat and to lead.

Its hard to remain in hiding from a virus, but we must stay the course, he said. Our concern is that the human spirit has only so much sacrifice that it can give, and people are reaching the end of their rope. The virus is still very active. We might be at a point where the rate of infection declines, but we have to be very careful, he said, and in fact we might be nowhere near that point, our great desire to be there notwithstanding.

I know that people are hurting, and we are in a very painful state economically, but when you take all the pain together, when you see how devastating this virus is, you see that this is the lesser pain. Its the lesser of two evils.

The Berrie Foundation also has given a grant to the Bergen Volunteer Medical Initiative.

Were a nonprofit health care center in Hackensack, the groups president and CEO, Amanda Missey, said. We provide free primary health care for people who are working but not earning much money, who live in Bergen County and dont have health insurance. The nonprofit has about 75 volunteers health care professionals, including several specialists, she said. In normal times, it is just like a regular doctors office. But nothing is normal any more.

Back before the pandemic, Bergen Volunteer Medical Initiatives Michelle Kaye, RN, its nurse manager, is on the phone. (COURTESY BVNI)

Because their patients have neither much money nor much time, they often live in small spaces with other people, and they often had low health literacy before this started. That put them at even higher risk for covid-19 infection than luckier, wealthier people have been. So not only do their patients suffer from a full range of health issues, exacerbated by low income and a history of infrequent access to health care outside emergency rooms, now they face the threat of this virus.

The Berrie Foundation is providing us with a very sizable grant for a telehealth program, Ms. Missey said. We have about a dozen nurses and nurse practitioners who want to be part of it, as well as our own clinical staff.

When the crisis first hit and social distancing began, when we were closed for those first two weeks, we really were just doing phone triage. Wed take the calls, order them in priority, and then dispense with them.

Now, though, the new platform allows patients and professionals to see each other. (Everyone has a phone, even if its a pay-as-you-go one, Ms. Missey said.) Its not the same as being in person there are nuances that are not visible over the phone, although body language and facial expressions can be; obviously, for example, you cant do a gynecological exam by telehealth, Ms. Missey said. But there are many check-ups and check-ins that are as useful by phone as in person, and require a lot less of the patients time.

Thats why this new system will be useful even when the crisis is over. We have been talking about telehealth for a long time, Ms. Missey said. But youre busy doing stuff every day, and so you cant make time for a new project, even when you want to. So this kind of forced our hand.

Well have the technology in place because of the grant, and we will be able to expand our capacity once this is all over, and we settle in our new normal.

There really are a lot of benefits to us from this. There arent many silver linings to covid-19, but this is one of them.

Dr. Robin Goland is the director of the patient care and clinical research programs at the Naomi Berrie Diabetes Center at Columbia University; the center is named for Angelica Berries late mother-in-law.

The Berrie Center provides care for and clinical research on 14,000 children and adults with diabetes, Dr. Goland said. This is a very high-risk time for diabetics; diabetes is one of the highest risks for covid-19.

Its not that they are more at risk for getting the infection, but that if they get infected it destabilizes their diabetes regimen, and the high blood sugars that ensue make it much harder to fight off the infection. And it seems to be emerging that high body weight which often but not always is associated with diabetes is also a big problem.

Given the dangers posed to its patients, and the impossibility of continuing as they had, in the face of the virus, we essentially have taken the large in-person practice model and moved it so it can function remotely, Dr. Goland said.

There are huge operational barriers to doing this; economic, technological, and emotional barriers. And the Berrie Foundation immediately leapt into action and supported us, our staff, and our patients, in making this enormous transition.

All of our visits are provided in virtual settings, on iPhones, and if we cant do that on iPads, and if we cant do that on FaceTime or Zoom, or if all else fails, on the phone. That required the staff all having the technological wherewithal that they just didnt all have. All the challenges with the office, the patients, the regimens its just mindboggling.

The Berrie Foundation helped us meet this huge challenge, so we could be there for our patients.

Like Ms. Missey at Bergen Volunteer Medical Initiative, going virtual, at least for some things, had been an idea that Berrie Center leaders like but upon which they had not had the time to focus, Dr. Goland said. And then it started, and it was a like a revolution. A tsunami. It is a remarkable transition, and we couldnt have done it without them. And the speed! she marveled.

Ms. Berrie wants as much publicity as possible for these and the other ventures that her foundation is supporting. Thats not because her name is attached to it, but because the whole point is that its a call to action, she said.

We cant do it alone. There are many others who have stepped up to do a lot.

She quotes the writer and activist Rebecca Solnit. Its about falling together instead of falling apart.

Its about how a community comes together in a crisis, instead of being like Lord of the Flies, where each one of us is in it only for ourselves.

Any friendly (or for that matter not-so-friendly) competition between institutions might drive each to greater heights during normal times, but competition is not helpful right now, she said dryly.

This situation is bringing out the best in most people, and the worst in others. Mike Maron can tell you how many people are looking to sell the hospital stuff, and some of them are price gouging, and taking advantage of this dire situation, she said. The community is being tested by this crisis. It is how we respond that will determine its character and resilience.

She talked about the institutions that her foundation is supporting with this first wave of grants, which also includes the local Diabetes Foundation, the Bergen Volunteer Center, and the Jewish Federation of Northern New Jersey; support also goes to seven Israeli nonprofits, all to help disenfranchised, elderly, or otherwise marginalized people there, and $1 million for Ogden Social Finance, which gives loans to small for-profit and non-profit businesses and groups in Israel.

The common thread in this first round is to help in the emergency, and not just by giving them cash. Much of the funds allocated on this first round will go to help organizations go virtual, helping them buy equipment that they can use once the emergency is over. Other funding goes to providing food to hungry people, and beyond that studying the issue of food security to make more structural changes. As that shows, we are already doing the homework for the second round, for more midterm needs, Ms. Berrie said. Its what we call the fuzzy middle.

Theres the initial response, the fuzzy middle, where you dont know what the needs will be, and then the long-term needs, which hopefully will be sustainable and will create a resilient infrastructure before the next crisis.

Ms. Berrie thinks a great deal about leadership, about the importance of leading by example, because leadership matters. She cites governors Andrew Cuomo and Phil Murphy as providing great examples of that leadership. And she does what she can in her world.

I am encouraging people in my sphere of influence in philanthropy not to think about their portfolios, she said. We are here to do the most good we can, wherever we can, and we just have to do it, even if we have to spend more now. Even if our portfolios have taken a hit, we have to do it.

This is the time to lead.

When she first converted to Judaism, she said, she asked about the value of doing a mitzvah, like giving tzedakah, publicly. Why should you allow yourself to be honored for doing something that you would have done anyway? But a friend explained that its because you have to set an example.

That shes done.

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Helping the helpers - The Jewish Standard

List of coronavirus treatments now being tested in clinical trials – Business Insider UK

Repurposed drugs are the most promising options for finding a treatment quickly for COVID-19, the disease caused by the novel coronavirus.

Dozens of clinical trials are enrolling patients and testing drugs originally designed for other ailments, such as Ebola, HIV, malaria, and arthritis. Results will trickle in over the coming weeks and months.

These potential treatments have already been tested in humans for other diseases, and some are already approved to treat other conditions. That means we already know how safe they are for people to take, and what side effects to expect. Therefore, researchers can skip some of the early steps of drug development, and instead move them quickly into human trials testing their efficacy in COVID-19.

While repurposed drugs can be tested now, they aren't expected to be anything close to a panacea for the virus. The gold standard for halting infectious diseases remains vaccines, which can protect healthy people from getting infected in the first place.

Vaccine research typically takes years. Even under the urgency of this pandemic, US health officials have said it will take at least a year to know if any vaccine is safe and effective.

Other biotech and pharma companies are scrambling to craft new therapeutics. These will be tailored specifically to fighting this novel coronavirus. Even under the most aggressive timetables for clinical testing, those won't be widely available to patients until at least the fall.

That leaves repurposed drugs as the near-term hope. Here are the top candidates and how they are being tested against COVID-19. These treatments have already been tested in people and are now in late-stage trials to find out whether they work against the coronavirus.

Original post:
List of coronavirus treatments now being tested in clinical trials - Business Insider UK