Category Archives: Stem Cell Doctors


GPs asked to review 1.5 million patients most at risk from coronavirus – Pulse

GPs should review 1.5 million patients identified by NHS England as the most vulnerable to the coronavirus (Covid-19).

NHS England will send a standard letter to these patients asking them to stay at home at all times and avoid any face-to-face contact for at least 12 weeks.

GPs will be able to access a report on which patients will be contacted with specific advice from today - with NHS England directing GPs to review the list and provide additional support to patients.

The patients, who are at'thehighest risk of severe illness that would require hospitalisation from coronavirus', include those who have had an organ transplant; people with specific cancers; people with severe respiratory conditions; people with rare diseases; people onimmunosuppression therapies; and pregnant women with significant heart disease.

NHS England said in a letter to GPs: 'We ask that you review this report for accuracy and, where any of these patients have dementia, a learning disability or autism, that you provide appropriate additional support to them to ensure they continue receiving access to care.'

GPs can identify the patients contacted by NHS England through an 'at high risk' indicator code that has been applied to each patient record by the practice's clinical system supplier.

'Your supplier will inform you of the code they have used, which should be treated as temporary until a definitive list of Covid-19 "at risk" SNOMED codes is released,' NHS England said.

'Your GP System supplier will also provide a report that will list those patients that have been centrally identified as being at high risk. You should have this by 23 March.'

But NHS England said central datasets were 'not sophisticated enough to identify all categories of patients who should be included in the vulnerable groups list' and it was therefore calling on GPs and specialist consultants to help identify patients who may have been missed.

The letter said: 'We appreciate this is a complex task requiring difficult judgements, and we ask for your help, as the GP central to the care of these patients, in achieving this.'

In a separate letter, England's chief medical officer Professor Chris Whitty asked GPs to add to the list of most vulnerable patients using their 'clinical judgement'.

The letter said: 'You may know of specific additional patients in your practice who you think are particularly high risk.

'On the other hand there are a limited number of people that we can shield effectively or for whom this highly socially isolating measure would be proportionate on health grounds; many patients who fulfil the criteria may after discussion with you prefer not to be placed under such strict isolation for what will be a prolonged period.'

1. Solid organ transplant recipients

2. People with specific cancers

People with cancer who are undergoing active chemotherapy or radical radiotherapy for lung cancer

People with cancers of the blood or bone marrow such as leukaemia, lymphoma or myeloma who are at any stage of treatment

People having immunotherapy or other continuing antibody treatments for cancer

People having other targeted cancer treatments which can affect the immune system, such as protein kinase inhibitors or PARP inhibitors.

People who have had bone marrow or stem cell transplants in the last 6 months, or who are still taking immunosuppression drugs.

3. People with severe respiratory conditions including all cystic fibrosis, severe asthma and severe COPD

4. People with rare diseases and inborn errors of metabolism that significantly increase the risk of infections (such as SCID, homozygous sickle cell disease)

5. People on immunosuppression therapies sufficient to significantly increase risk of infection

6. People who are pregnant with significant heart disease, congenital or acquired

Source:NHS England

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GPs asked to review 1.5 million patients most at risk from coronavirus - Pulse

The American Academy of Stem Cell Physicians Recommends a Treatment Protocol for COVID-19 to the WHO – Yahoo Finance

Treatment plans are outlined for doctors and hospitals by The American Academy of Stem Cell Physicians

MIAMI, March 19, 2020 /PRNewswire/ --The American Academy of Stem Cell Physicians has Recommendations for the Treatment of COVID-19. Treatment plans were sent to the WHO representatives and DirectorDr. Tedros Adhanom earlier today.

The following are recommendations of The American Academy of Stem Cell Physicians for treatment of COVID-19:

For Hospitalized Patients (Based on 70KG weight):

1. Intravenous Vitamin C 50 grams QD (Need to check patients for G6PD deficiency before high dose IVC.)2. Zinc 8mg IV QD3. Vitamin D3 100000-150000 IU Intramuscularly QD4. Chloroquine 10mg/kg bid5. Umbilical Cord Blood - 1 million MNC/kg QD6. Nebulizer with Amniotic fluid derived Exosomes 1 Billion/Kg Q4h.

Please note the vitamins and minerals are given at a higher dose than are normally recommended and physicians should do prophylaxis for gastrointestinal protection and add probiotics.

Non-Hospitalized Patients:

1. Zinc 40 mg BID2. Vitamin C 5000mg/day3. Chloroquine 500mg BID initial loading dose of 1000mg4. Vitamin D 5000 IU QD5. Oral iodine 300mg PO bid

6. Dietary and lifestyle recommendations:a. 8oz of water/hourb. No sugarc. More vegetables at each meal.d. Exercise 30 minutes per day.e. Meditate.f. Sleep minimum of 7-8 hours/day.

A spokesman for The American Academy of Stem Cell Physicians, Dr. A.J. Farshchian said earlier today,"The AASCP members have been working on the above protocol this past week. We have to thank all the physicians contributing to this protocol in particular."

Thephysicians are :

Kristine Salter, M.D.Sunny Kim, M.D.Pedro Abrantes, DPMTom Yarema, M.D.Robert Hamilton, M.D.

This protocol is to be tailored for each individual patient. Physicians from around the world are welcome to contact us, as we will continuously be updating this protocol.

For updates, check The American Academy of Stem Cell Physicians website: http://www.aascp.net.

About AASCP

The American Academy of Stem Cell Physicians (AASCP) is an organization created to advance research and the development of therapeutics in regenerative medicine, including diagnosis, treatment, and prevention of disease related to or occurring within the human body. The AASCP aims to serve as an educational resource for physicians, scientists, and the public.

Contact Marie Barba at AASCP.net or305-891-4686.

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aascp-recommendations-to-treat.jpeg AASCP recommendations to treat Covid-19 AASCP recommendation memo

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SOURCE The American Academy of Stem Cell Physicians

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The American Academy of Stem Cell Physicians Recommends a Treatment Protocol for COVID-19 to the WHO - Yahoo Finance

March 21: 7 best things that happened this week – The Vanderbilt Hustler

Whether youre feeling anxious, stressed, fearful or straight bored, everyones emotions were running high this week. But believe it or not, some (shocker!) actually great things happened while we were drowning in the headlines. Read on for the seven best things that happened over the last seven days.

MAttigan Kelly

While the world feels like it's falling apart, at least people are fostering more puppies! Read on for other great things that happened this week.

1. Britney Spears made a stand for herself and, well, everyone.

Contrary to popular belief, Britney is very much still in. If you dont follow her Instagram, do yourself a favor, follow it and prepare for your feed to be flooded with her washboard abs and clich screenshots of quotes thatll bring you back to 2012. At 38 and with 2 kids, I can only hope to look like Britney when I grow up. With that being said, she receives her fair share of hate on social media for her Ill post whatever I want attitude and stream of bikini shots. On Wednesday, the Queen of Pop had had enough. She clapped back on all her haters with a genuine post (featuring yet another screenshotted quote) advocating for her right to basically do what she wants and post what she wants without having to deal with online bullies. Especially in todays climate of fear and anxiety, Britney shouldnt have to deal with strangers telling her what to post, and neither should we.

2. The second patient ever was cured of HIV in London.

While everyones busy worrying about not contracting COVID-19, a medical breakthrough happened on March 10 in London. Fourty-year-old Adam Castillejo had been taking HIV medication for months, but it was not that which cured him. Doctors say a stem cell treatment that he received for cancer involved an uncommon gene which stopped the virus from replicating in his body. It is now a year after he was announced clear of the virus, which researcher Prof. Ravindra Kumar Gupta told BBCindicates an almost certain cure. While the solution isnt permanent for certain, it is a step in the right direction for the millions of people living with HIV.

3. People adopted more pets.

At this time, there is no evidence that pets can spread COVID-19. What does that mean for America? More adoption, apparently! Mans best friend comes in clutch yet again, providing endless entertainment for the millions of Americans feeling lonesome in their homes. However, not everyone is willing to take the plunge with a permanent pet pal in this time of economic uncertainty; according to The New York Times, the number of fostering requests across the United States have spiked in recent weeks. Not only is this benefitting the animals themselves whod otherwise be isolated in kennels, but it satiates the need for companionship that their new owners are craving. Reach out to your local Humane Society or Animal Care Center to learn more about how you can adopt or foster a pet in your area.

4. Italians went off.

If you havent seen the videos trending all over Twitter and Instagram, I dont know where youve been. Italians have been doing the most while under strict quarantine, taking their energy and flair to their balconies while singing hit singles karaoke-style. Theyve pulled out all the stops, even bringing out instruments to serenade each other across the streets. Time and time again, history has proven the strength of the unifying power of music in hardship, and this is no exception. The countrys death toll may surpass even Chinas, but that hasnt stopped Italians from trying to have a good time.

5. People actually started using Netflix Party.

Lets be honest, when you and your friends hang out, 5 percent of the time is spent going on spontaneous outings while the other 95 percent blows by while youre on the couch watching Netflix. With Netflix Party, a Chrome extension that synchronizes your Netflix screening, you can still host movie nights with virtually (pun intended) everyone. After downloading the extension from netflixparty.com, all you have to do is open Netflix in your browser, start watching your favorite show, and then click the NP on the upper-right corner of your screen. From there, a chat should pop up, providing you with a sharable link that you can send to all your friends. But wheres the virtual popcorn?

6. Google Arts and Culture allowed us to stroll through online museums.

Google Arts & Culture is what some would call the pioneer of virtual exploration, partnering with over 500 global art institutions to allow anyone with internet access to interact with the same enriching experience of a traditional museum from the comfort of their La-z-boy. The app officially launched in 2016, but the latest advancements in virtual reality provide a whole new platform to experience while youre bundled up at home. Whether you want to stroll through Versailles or make a pit-stop at the National Museum of Modern and Contemporary Art in Korea, the innovators at Google allow you to do it all.

7. Everyone got better at TikTok dances.

At this point in quarantine, youd be lying if you said you hadnt even tried to memorize a TikTok dance with all this time on your hands. Savage by Megan Thee Stallion (shoutout Commodore Quake) has gone viral on the popular app, with everyone from Tyler and Hannah (The Bachelorette lovebirds) to Megan Thee Stallion herself taking their shot at the trending dance. The hashtag #boredathome has also been flooding everyones TikTok For You page, featuring families and their various shenanigans while on lockdown. But seriously, why does everyone have a funny dad?

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March 21: 7 best things that happened this week - The Vanderbilt Hustler

Letters to the editor: Goose feces – News – Mount Shasta Herald

FridayMar20,2020at12:01AM

This letter is not intended to impugn the service, doctors or staff of Mercy Medical Hospital of Mount Shasta.

There is however an issue that I have tried to call attention to for the last 4 years. The geese. I am a stage 4 lymphoma cancer survivor, and a stem cell transplant recipient.

The issue is that the feces from the geese, its everywhere including the roof of the building. I know that the hospital has made a major effort to wash the sidewalks down. Not getting all the mess and not realizing that what was washed into the grass dries out and becomes airborne when disturbed.

You really must pay attention to where you walk because if you step in it and take it home on your shoes, it gets on your carpet or other surfaces and dries then can become airborne.

I happened by chance to speak with a hospital board member that admitted the hospital made a major mistake in putting in the pond at the hospital.

Having spent time in the UC Davis Medical System (not the cleanest), I hold Mercy Medical in Redding as the most biologically clean facility in northern California, Mount Shasta would be next if the pond and geese were gone.

Please dont ignore this issue. I would be glad to help find a solution.

Ken Roseberry

Mount Shasta

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Letters to the editor: Goose feces - News - Mount Shasta Herald

For Texas ill and immunocompromised, coronavirus brings a new threat and familiar precautions – KSAT San Antonio

After she stocked the deep freezer and canceled the physical therapy appointments, there still remained the problem of the mail.

At first, Shannon Huehlefeld would pick it up in a pair of hospital gloves she keeps a box by the door and thumb through it carefully. If she needed a letter immediately, shed spray it with Lysol on both sides. Everything else she just let sit. The virus, she knew, can live on some surfaces for days.

Shed been thinking about her vacuum, which has a light on its underside thats supposed to sterilize the floor beneath it. Then, last week, while she was shopping online for bacterial wipes, a solution appeared as a suggested purchase: a UVC bulb that can sterilize a surface in 30 minutes or less. She bought one she can screw into a clip-on lamp above the counter in the laundry room. Shell do one side, then flip the mail over and do the other.

Huehlefeld is not letting anyone in or out of the house near the Gulf Coast in Freeport that she shares with her husband, Ken, and their two Maltese mixes. That goes for the two of them and, unfortunately, for her niece, who after losing her mother in January had been coming over to see them a lot.

I said, Im sorry, Im so sorry, I miss you and I want to see you but I cannot let anybody get my husband sick, said Huehlefeld, 49. Spraying the mail I know it seems ridiculous. But I dont know where this [virus] stuff is, and they dont know where this stuff is. They dont even know who has it and where it is and where its not.

I cannot let my husband get sick, she continued, in something of a mantra. He doesnt know that he could survive a bad respiratory illness like that.

For Texans with compromised immune systems or those with sick loved ones the precautions being taken in the face of the new coronavirus are high stakes, and in some cases extreme. The limited scientific research about the mysterious COVID-19 shows it is deadliest for the elderly and the sick. Already, thousands have died worldwide and at least 69 people are infected in Texas.

But if only the immunocompromised are careful, the virus will continue to spread rapidly. Experts are exhorting even the young and healthy to limit social interaction in order to flatten the curve, slowing the rate of infection to ensure hospitals can care for all who fall ill. Cities across the county, including Dallas and Houston, have closed bars and banned dine-in service at restaurants in an effort to limit the spread of the virus. The Centers for Disease Control and Prevention recommended canceling any event of more than 50 people for the next eight weeks. But some in the most vulnerable population fear not everyone is taking the outbreak seriously enough.

Shannon Huehlefeld has rheumatoid arthritis, which means her immune system mistakenly attacks healthy cells in her body, causing severe fatigue and making it painful to move around. But she worries more about her husband, a retired sheriffs deputy, who is 63 and diabetic. In December 2014, he spent 10 days in intensive care with diabetic ketoacidosis, a serious complication of diabetes. He hasnt been the same since, she said; he lost the majority of his muscle mass, and hes very frail, with a history of lung issues and pneumonia. She still remembers the nurse scolding her for not bringing him in sooner.

She hasnt left the house since Super Tuesday two weeks ago, and when she did, she wiped down the car as best she could. They have at least a months supply of groceries; the deep freezer is so full it wont close. Worst-case scenario, shell ask her niece who is young and healthy and has been making a mint lately, working for a grocery delivery service to bring something by. Then shell get out her Lysol.

The coronavirus threat is new, but for many, the precautions are familiar. Its a collective-action conundrum that keeps the immunocompromised up at night. They are doing what they can. They just wish others would take the same steps.

We are perpetually at risk, said Shelby Chiles, 42, who along with her mother has neuro-Behcets, a rare autoimmune disease. Both wear nasal cannulas and rely on external oxygen supplies. Her husband works as a high school teacher in Frisco ISD essentially a petri dish, she said.

Its not really that different for me and my family on a day-to-day level, because we have to be cautious every day, she said. Its just the overwhelming response to how everyone else is being cautious. I wish that people used common sense and hygiene proper hygiene on a daily basis.

Renee Brown of Corinth is in her 50s, but she has what her doctor calls an immature immune system, like it was a child. Nineteen months after undergoing a stem cell transplant, she is no longer taking immunosuppressants, but she is still taking care. She has aplastic anemia, an autoimmune disease in which the bone marrow produces insufficient blood cells, and after her transplant, she spent weeks isolated in the hospital. She knows for her, the virus could be a problem.

But the virus doesnt frighten me, she said. Im not afraid of it because I know what to do. I have kind of had this lifestyle, of having to avoid the flu because I couldnt get vaccinated for it. Im actually pretty used to avoiding crowds when I can, washing my hands, that sort of thing.

Its other people she frets for more. She remembers from her months of isolation that some friends dont take illness seriously. They dont understand they need to stay away when theyre fighting a cough or running a fever. Theyre not cautious in public places. Some end up drifting away.

People dont understand, and they often dont comply, she said. They think about colds and flus in terms of things people get over.

For Tessa Phillips, who has had a weak immune system ever since she underwent a bone marrow transplant as a teenager, what might be a cold or bronchitis for a healthy person turns into walking pneumonia. Her ear infections turn into mastoiditis. She worries about what the new virus could do to her.

I dont think other people should be foolish about how they take care of themselves and impose that upon you, she said.

A year before the virus began to spread in Texas, she was already taking precautions to keep herself from getting sick when she had to travel for work. She drives instead of flying; she avoids hotels near airports; she skips restaurants and loathes gas stations.

But she knows others are not so careful. On Friday morning, the sound of a hacking cough from somewhere in her apartment complex sent her and her husband spinning.

Right now, it seems like its a very stark contrast: You either have doomsday preppers buying all the toilet paper, or youve got people who are just out and about like nothings happening, she said. All of us should be somewhere in that sweet spot in the middle. We all need to get in the middle together. But 6 feet away from each other.

There have not been any cases confirmed yet in Winnsboro, the rural East Texas town of about 3,300 where Bette Swann, 76, lives. But in Tyler, about 40 miles away, three people tested positive, the city announced Friday.

Thats getting really close to home, she said. Thats where my doctors are and where we go shopping.

When Swann goes to see her doctor in May, itll mark 14 years in remission from lung cancer. She was never a smoker, but she has half a lung missing, chronic obstructive pulmonary disease and asthma, as well as the autoimmune disease lupus. Her husband will be 80 next month.

So they are quarantining themselves at home, where she has already spent a not-insignificant portion of her time chastising Facebook friends who claim the virus is a hoax. When her sister called to remark on how few people were at Red Lobster for lunch Thursday, Swann scolded her, too: You shouldnt have been there, either.

Swann wasnt always so careful, even after cancer. She and her husband would leave the grocery store, and shed touch her face. He would scold her if she didnt use hand sanitizer first.

He really just kind of grounded me, she laughed. Id say, Dont tell me that! I can touch my nose if I want to.

But Im not doing that now, she said. I kind of learned.

Swann always gets the flu vaccine, but she still got the flu two of the last three years. Both times, it kept her bedridden for two weeks. One year, right before Christmas, the doctor told her she would need to be hospitalized if her fever didnt go down in 24 hours. She would have missed the holiday with her children. A day later, she felt well enough to go home.

She knows from her niece, an internist, that the threat of the coronavirus is far greater than that of the flu. She and her husband are up near that dangerous age. And she knows that her poor health makes her vulnerable.

Im in remission, but my immune systems not well. Evidently Im more prone to get sick, she said. Knowing how the flu affected her, she is scared about an illness that could hit her lungs even harder.

Swann and her husband dont much mind being home, where they stay most of the time anyway. They love to read. When it gets a little warmer, shell plant flowers in their garden. Her husband plants the peas.

They plan to call in grocery orders so they can get food delivered straight to the car. She doesnt miss eating out, but she does miss going to Walmart. And she hates that theyre not going to church.

Recently, Swann read a news story about a couple in Northern Italy who reportedly died of the virus within two hours of each other. Severa Belotti was 82, and Luigi Carrara was 86.

The story has stuck with her. They were just like my husband and I, active in their lives we go to church, we work in the garden, she said.

They had been isolated at home, and their son wasnt even able to see them before they died, she recalled. How sad that mustve been.

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For Texas ill and immunocompromised, coronavirus brings a new threat and familiar precautions - KSAT San Antonio

Disruptions in cancer care in the COVID-19 era – NewsDio

What your doctor is reading on Medscape.com:

MARCH 20, 2020 Even in the midst of the COVID-19 pandemic, cancer care must continue, but changes to the way care is provided may be necessary."We are heading toward a time when there will be significant disruptions in the care of cancer patients," said Len Lichtenfeld, MD, deputy chief medical officer for the American Cancer Society (ACS), in a statement. "For some it may be as simple as a delay in elective surgery. For others, it may be delaying preventive care or adjuvant chemotherapy to prevent cancer from coming back or rescheduling appointments."Lichtenfeld emphasized that cancer care teams will do their best to provide care to those most in need. However, even under those circumstances, life will not be as usual. "It will take patience from everyone as we go through this pandemic," he said."The way we treat cancer in the coming months will change enormously," writes a British oncologist in an article published in The Guardian."As oncologists, we will have to find a tenuous balance between insufficient treatment of people with cancer, leading to more deaths from the disease in the medium and long term and the increase in deaths from COVID-19 in a population of vulnerable patients. Together with our patients, we will have to make difficult decisions regarding treatments, with only low-quality evidence to guide us, "writes Lucy Gossage, MD, consulting oncologist at the University Hospital of Nottingham, UK.Evidence to date (from China's Lancet Oncology reports) suggests that people with cancer are at significantly higher risk of serious disease resulting in intensive care admissions or death when infected with COVID-19, particularly if they recently received chemotherapy or surgery."Many of the cancer treatments we use today, especially those given after surgery to reduce the risk of cancer recurrence, have relatively small benefits," he writes."In the current climate, the balance of offering these treatments may change; a small reduction in the risk of cancer recurrence in the next 5 years may be offset by the potential for a short-term increase in the risk of death from COVID- 19. In the long term, more people's cancer will come back if we can't offer these treatments, "he adds.

Continued

Postpone routine detection

One thing that may be in the background for now is the routine cancer screening, which can be postponed for now to conserve health system resources and reduce contact with health centers, ACS says."Patients seeking routine cancer screenings should delay them until further notice," said Lichtenfeld. "While early detection is important, the need to prevent the spread of the coronavirus and reduce strain on the medical system is more important at this time."But as soon as restrictions are lifted to reduce the spread of COVID-19 and routine visits to health facilities are safe, regular screenings should be rescheduled.

ASCO Orientation

The American Society for Clinical Oncology (ASCO) has released a new guide on caring for cancer patients during the COVID-19 outbreak.First, ASCO encourages providers, centers, and anyone caring for cancer patients to follow existing guidelines from the Center for Disease Control and Prevention (CDC) when possible.ASCO highlights the CDC's general recommendation for healthcare facilities that suggests that "elective surgeries" in inpatient facilities be rescheduled if possible, which has also been recommended by the American College of Surgeons.However, in many cases, cancer surgery is not elective but essential, he notes. Therefore, this is very much an individual determination that doctors and patients will need to make, considering the potential harm of delaying the cancer related surgery that is needed.Systemic treatments, including chemotherapy and immunotherapy, leave cancer patients vulnerable to infection, but ASCO says there is no direct evidence to support changes in regimens during the pandemic. Therefore, it is not recommended to routinely discontinue anticancer or immunosuppressive therapy, as the balance of potential harm that may result from delaying or stopping treatment versus the potential benefits of possibly preventing or delaying COVID-19 infection remains very unclear.Clinical decisions should be individualized, ASCO emphasized, and suggested that the following points of practice be considered:

For patients who are already in deep remission and who are receiving maintenance therapy, stopping treatment may be an option.

Some patients may switch from IV to oral therapies, which would decrease the frequency of clinic visits.

Decisions about modifying or discontinuing chemotherapy should take into account both the indication and the goals of care, as well as the patient's location in the treatment regimen and tolerance to therapy. As an example, the risk-benefit assessment for continuing chemotherapy in patients with untreated extensive small cell lung cancer is quite different from proceeding with pemetrexed maintenance for metastatic non-small cell lung cancer.

If local coronavirus transmission is a problem at a particular cancer center, reasonable options may include taking a 2-week break from treatment or scheduling treatment at a different center.

Assess whether the infusion at home is medically and logistically feasible.

In some settings, delaying or modifying adjuvant treatment presents a higher risk of compromised disease control and long-term survival than others, but in cases where the absolute benefit of adjuvant chemotherapy may be quite small and there are other options. available, the risk of COVID -19 can be considered an additional factor when evaluating care.

Continued

Delaying stem cell transplants

For patients who are candidates for allogeneic stem cell transplantation, a delay may be reasonable if the patient is currently well controlled with conventional treatment, ASCO says. It also directs physicians to follow the recommendations provided by the American Society for Transplantation and Cell Therapy and by the European Society for Blood and Marrow Transplantation regarding this matter.Finally, there is also the question of prophylactic antiviral therapy: should it be considered for cancer patients undergoing active therapy?The answer to that question is currently unknown, ASCO says, but "this is an active area of research and the evidence may be available at any time."

Medscape Medical News

2020 WebMD, LLC. All rights reserved.. (tagsToTranslate) cancer (t) malignancy (t) carcinoma (t) Coronavirus (t) 2019 New coronavirus (t) 2019-nCoV (t) Wuhan coronavirus (t) Human coronavirus HKU1 (t) Human coronavirus OC43 (t) HCoV -OC43 (t) Human coronavirus 229E (t) HCoV-229E (t) chemotherapy (t) biological therapy (t) immunotherapy (t) cancer risk (t) pandemic (t) transplant (bone marrow) (t) bone marrow transplant (t) bone marrow (transplant) (t) bmt (t) hematology (t) patient safety

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Where We’re at with Vaccines and Treatments for COVID-19 – Healthline

With COVID-19 cases worldwide passing the 200,000 mark and continuing to grow, scientists are pushing forward with efforts to develop vaccines and treatments to slow the pandemic and lessen its damage.

Some of the earliest treatments will likely be drugs that are already approved for other conditions or have been tested on other viruses.

People are looking into whether existing antivirals might work or whether new drugs could be developed to try to tackle the virus, said Dr. Bruce Y. Lee, a professor of health policy and management at City University of New York.

Still, theres only so much that vaccine and drug development can be sped up, even with improvements in genetic sequencing and other technologies.

Even though technological advances allow us to do certain things more quickly, Lee told Healthline, we still have to rely on social distancing, contact tracing, self-isolation, and other measures.

Heres a rundown of the latest COVID-19 vaccine and drug developments.

Several companies are developing or testing antivirals against the virus that causes COVID-19.

Antivirals target the virus in people who already have an infection. They work in different ways, sometimes preventing the virus from replicating, other times blocking it from infecting cells.

Lee says antivirals work better if you administer them sooner, before the virus has a chance to multiply significantly.

And also before the virus has caused significant damage to the body, such as to the lungs or other tissues.

Dr. Robert Amler, dean of the School of Health Sciences and Practice at New York Medical College and former chief medical officer at the Centers for Disease Control and Prevention (CDC), says both antivirals and vaccines will be valuable tools in combating COVID-19.

However, he told Healthline that antivirals are likely to be developed and approved before a vaccine, which typically takes longer.

Drug development is sometimes described as a pipeline with compounds moving from early laboratory development to laboratory and animal testing to clinical trials in people.

It can take a decade or more for a new compound to go from initial discovery to the marketplace. Many compounds never even make it that far.

Thats why antivirals being eyed as treatments for COVID-19 are drugs that already exist. They include:

Scientists are also looking at other ways to target the virus or treat the complications of COVID-19, such as:

While a lot of the focus is on developing new treatments for COVID-19, improvements in how doctors care for patients using existing technology are also crucial.

The things that we have to worry about with the novel coronavirus is that it can cause pneumonia and acute respiratory distress syndrome, Lee said. There are ways of treating those things that can reduce the effects, so doctors are trying to use those as well.

No company has offered a timeline for when its drug might be used more widely to treat COVID-19. This isnt an easy thing to estimate.

After laboratory and animal testing, drugs have to pass through several clinical trial stages before they can be approved for widespread use in people.

Its also difficult to speed things up, because scientists have to enroll enough people in each stage to have useful results. They also have to wait long enough to see whether there are harmful side effects of the drug.

However, drugs can sometimes be given to people outside a clinical trial through the Food and Drug Administrations compassionate use program. For this to happen, people must have an immediately life-threatening condition or serious disease or condition.

Doctors at the University of California, Davis were able to secure this type of approval for a woman with severe COVID-19 to receive remdesivir. They report that shes now doing well.

Many will take this as a sign that the drug works. But because the drug was given outside of a clinical trial to just one person, its not possible to know for certain. Also, other people may not have the same response to the drug.

A vaccine is designed to protect people before theyre exposed to a virus in this case, SARS-CoV-2, the virus that causes COVID-19.

A vaccine basically trains the immune system to recognize and attack the virus when it encounters it.

Vaccines protect both the person whos vaccinated and the community. People who are vaccinated cant become infected with a virus, which means they cant pass it to others. This is known as herd immunity.

Many groups are working on potential vaccines for SARS-CoV-2, with several backed by the nonprofit Coalition for Epidemic Preparedness Innovations (CEPI).

Several of these groups started their work shortly after Chinese scientists shared the genetic sequence of the virus. These include:

Advances in genetic sequencing and other technological developments have sped up some of the earlier laboratory work for vaccine development.

However, Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, told reporters last week that a vaccine wont be available for widespread use for at least another 12 to 18 months.

This is the timeline to complete the phase III clinical studies. Theres no guarantee that the vaccine candidates will work.

Theres a lot of uncertainty with vaccine development, Lee said. Naturally, you have to make sure the vaccine is safe. But you also have to make sure the vaccine will elicit enough of an immune response.

Like drugs, potential vaccines have to pass through the same clinical trial stages. This is especially important when it comes to safety, even during a pandemic.

The publics willingness to back quarantines and other public-health measures to slow spread tends to correlate with how much people trust the governments health advice, Shibo Jiang, a virologist at Fudan University in China, wrote in the journal Nature.

A rush into potentially risky vaccines and therapies will betray that trust and discourage work to develop better assessments, he said.

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Where We're at with Vaccines and Treatments for COVID-19 - Healthline

Eliminating the Fear Factor – Chicago Health

Testicular cancers high cure rates turn panic into promise

Testicular cancer rarely makes the headlines. Because so few men are diagnosed with the disease each year the American Cancer Society puts the number of new cases at 9,610 annually many men dont pay attention to it. But they should. The earlier testicular cancer is detected, the easier it is to cure.

Cancer of the testicles the organ that produces sperm and testosterone typically affects young men. The average age at diagnosis is 33, according the American Cancer Society. But the age range is wide: About 6% of cases are found in children and teenagers and about 8% in men over age 55.

We do know that this is a cancer that is most common between the ages of 15 and 35, but we dont know why, says Britt Hanson, DO, a hematologist/oncologist at NorthShore University HealthSystem.

Some notable cases affecting young athletes have made headlines. Figure skating fans will remember Olympic medalist Scott Hamilton, who returned to the sport after being treated for testicular cancer at age 38. And cyclists may recall that Lance Armstrong was diagnosed with stage 3 testicular cancer when he was 25 years old. After Armstrong successfully underwent treatment for the disease which had spread to his abdomen, lungs and brain he continued to compete and have more children.

Fortunately, the disease is rarely fatal. A mans lifetime risk of dying from testicular cancer is about 1 in 5,000, according to the American Cancer Society.

The earlier the disease is diagnosed, the easier it is to treat, Hanson says, and even if it travels to the brain or the lungs, it is curable.

Treatment is effective, says Michael McGuire, MD, a urologist at Northwestern Medicine. The five-year survival rate is 99% if the cancer hasnt spread. It is one of the greatest success stories in the history of medicine, he says.

This is a disease that is emotionally scary. But the reality is that we have the opportunity of getting [people] back to doing everything they did before treatment.

While there are many forms of testicular cancer, more than 90% of cases are germ cell cancers that start in the cells that make sperm. Treatment depends on the stage, type and size of the cancer. Diagnosing the disease early opens up more treatment avenues, McGuire says.

Earlier detection is important, he says, because it allows for more opportunity for options of treatment.

Depending on the stage, physicians may recommend active surveillance to follow the individual regularly for any further signs of cancer. Usually, surgery is needed to remove the affected testicle.

And sometimes, doctors also remove lymph nodes in the abdomen to prevent future cancer. Chemotherapy is an option for a disease that has spread, McGuire says.

We want to give men the best treatment with the least side effects, McGuire says. Sometimes we do chemotherapy, stem cell transplantation or immunotherapy for advanced disease, but most men dont need anything that aggressive.

While men who have a testicle removed may be concerned about their ability to have children, McGuire says the cancer does not affect fertility in most men. Even if one testicle is removed, another functioning one remains.

If necessary, there are ways to retain fertility. We have the opportunity to store sperm, and we have a specialist who can get sperm from a testicle with cancer in it, McGuire says.

Testicular cancer, however, doesnt only have a physical effect; theres an emotional effect, too. This is a disease that is emotionally scary, McGuire says. Young men seeing their mortality is a shock, especially when it involves losing a part of their genitalia. But the reality is that we have the opportunity of getting them back to doing everything they did before treatment.

To catch testicular cancer early, McGuire recommends that every man conduct a self-exam each month after puberty for signs of the disease. Any hard spot in the testicles should be seen by a doctor, he says. The problem is, he adds, even after feeling a lump, many men wait six to eight months before they see a physician.

Theres no reason to wait, because the vast majority of the lumps and bumps that men feel in their testicles are not testicular cancer, McGuire says. Nothing makes me happier than to say, This isnt cancer. You have nothing to worry about.

But seeking medical attention early is key to a proper diagnosis. And with the good prognosis for testicular cancer, its possible to eliminate the fear factor.

Nancy Maes, who studied and worked in France for 10 years, writes about health, cultural events, food and the healing power of the arts.

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Eliminating the Fear Factor - Chicago Health

Four pandemics that changed the world – AL DIA News

When the World Health Organization (WHO)labeled the new COVID-19a "pandemic", that is, a disease that is occurringall over the world at the same time, there were moments reminiscentof times of war: thedeserted streets, supermarkets overwhelmed by hundreds of people scrambling for goods, and the constant media monitoring of the infection's progress the number of sick and dead increasing daily.Although our health system is not what it was in 1918, when the Spanish Fluwreaked havoc, nor will the coronavirus be as lethal as smallpox the most deadly pandemic some people will still make historical comparisons.To keep you up to date with what's happening now and what's happened in the past, here's tour of the five most devastating pandemics that we've emerged from.

HIV/AIDS

It has killed more than 25 million people worldwide, and although preventive treatments such as PrEP have been developed toreduce infections by 90%, a global cure has yet to be found.HIV originated in Africa, where apes have an HIV-like virus known as SIV.

Scientists still speculate on whether interspecies contagion occurred from hunting or eating infected chimp meat.AIDS wasn't detected as a disease until the 1980s, when it was observed in the United States, especially among homosexual patients in New York and California. It was later determined an evolution of the HIV infection, which transmitted through any passage of bodily fluid (intravenous drug usage and sexual intercourse were the most common). Doctors named it acquired immunodeficiency syndrome (AIDS)because the virus attacks the white blood cells that help fight infection.Today, there are two patients worldwide who have been cured of HIV thanks to a stem cell transplant whose donor carried a mutation known as CCR5-delta 32.

The Black Death or Bubonic Plague

It ravaged the European continent from the mid-14th century until its last outbreak three hundred years later and is responsible for more than 75 million deaths.

Although at that time the devastating epidemic was attributed to Divine Cholera and even to the passage of a comet, the origin was a bacterium that appeared in Asia and spread through parasites such as rat fleas. Its spread originated at trade ports, and was helped by the poor hygiene conditions and diet of the time period.

Death occurred in less than a week after the disease manifested, with the appearance of buboes - or swelling of nodes in the lymphatic system - accompanied by high fevers, delirium, chills and stinking suppurations. The sick were confined to their homes along with their families as means of containment. In some cases, it wiped out whole villages in Europe, which were sometimes discovered hundreds of years later.

Spanish Flu

The disease gotits name during WWI fromSpanish newspapers, which remained neutral in the conflict, and were the only ones to report on its lethality without censorship.

It is believed that Spanish Flu was responsible for between 50 and 100 million deaths and some the first cases reported were among the United States military, who could have broughtit to Europe when they landed to fight the Germans. Regardless, there are many theories around its origin.

As deadly as it is heartbreaking, there were cases in the United States of people rising with fever and dying on their way to work.

In a previous article, we commented on why its fatality rate, which is often used incomparisontoCovid-19, is wrong, as it is well over the 2% reported by WHO.

Smallpox

Holding the position of the most devastating global pandemic,Smallpoxhas contributed to the decline of entire civilizations such as the Aztec and Inca Empires when theSpanish brought the disease in their "conquest" of the New World in 1519. It is estimated that 90% of indigenous deaths during European colonization were not due to "fire," but rather, disease.

In Europe, smallpox killed 60 million people in the 18th century alone, and a hundred years later there were 300 million deaths worldwide.

Its Latin name means "spotted", because of the bumps and bruises that appeared on the faces of those afflicted. It was highly contagious and those who survived would carry marks on their skin for the rest of their lives, and some even wentblind.

One of modern medicine's greatest achievements was the creation of a vaccine for smallpox in 1979. As a result, Smallpox is considered eradicated.

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Four pandemics that changed the world - AL DIA News

INNOVATION IN HEALTHCARE MAKES MEDICAL TREATMENTS EFFICIENT AND ACCESSIBLE EFFORTS OF DR. SHARMILA ANANDASABAPATHY – RecentlyHeard.com

The automotive sector, corporate world, educational system, and healthcare are under a strong technological influence. Every day smart innovations and advanced technological solutions are introduced that can enable breakthrough performance and enhance efficiency. Cryptocurrencies, voice assistants, driverless vehicles, reusable rockets, and robot assistants are some of the innovations that are changing the world for better. There are some amazing innovations in the healthcare sector that are making medical treatments efficient and accessible to the world.

Drone delivery of medical supplies by David Abney, a stem-cell cure for diabetes by Doug Melton, 54gene by Abasi Ene-Obong, CTRL-kit by Thomas Reardon, and The SmartPod by Baylor College of Medicine are few revolutionary healthcare technological solutions. The benefits of these smart solutions make healthcare efficient. Out of all these innovations, SmartPods is an innovation that makes healthcare accessible to people living in the rural parts of the world. The easy-to-transport healthcare facility was created by a team of medical experts with Dr. Sharmila Anandasabapathy, a Sri Lankan-American physician, as the primary creator.

The SmartPod is a deployable healthcare facility that was developed at The Baylor College of Medicine in response to the 2014 Ebola epidemic. The purpose of the SmartPods was to reduce the response time and effectively address the medical emergencies or disease outbreaks in remote or underserved parts of the world. These pods are aluminum containers with steel frames that meet ISO shipping standards. These are fully-equipped to provide high-quality healthcare to people residing in regions lacking quality healthcare.

The SmartPods are standard shipping containers of 820 feet and can be easily transported by air, by sea, and by road. The containers can turn into a proper 400+ square foot healthcare facility in less than five minutes. These pods open manually with just four people. Efforts have been made in the past to provide top quality medical care to inaccessible parts of the world. However, the absence of technological equipment and improper communication channels made it impossible for healthcare professionals to extend their services to the people deprived of reliable medical care.

Currently, several units have been deployed worldwide as clinics, laboratories (BSL 2 and BSL 3), and pharmacies. Operating rooms and isolation units for respiratory pathogens (SARS-COVID-2) are also being developed. The SmartPods are deployed globally, and they feature a UV and HEPA filtration system which maintains a hygienic environment in these pods by filtering out the allergens and pathogens that spread viruses. Other features of these pods include air conditioning, disinfectant-ready surfaces, temperature-controlled pharmaceutical inventory, and hardware /software for telemedicine or teleguidance.

Dr. Sharmila Anandasabapathy has put in significant efforts to make these deployable pods a possibility. Her research and hard work are helping the world cater to disease outbreaks efficiently in both urban as well as rural parts of the world.

The primary focus of Dr. Sharmila Anandasabapathy is on gastrointestinal cancer. The Sri Lankan-American physician is involved in extensive research on using novel technologies that can make cancer diagnosis and treatment quick and efficient. Trained in advanced gastrointestinal endoscopy says that cancer in complex parts of the body makes it difficult for the doctors to make an accurate diagnosis. To treat gastrointestinal cancer, doctors must identify the exact affected areas. Neoplastic growth in the body is typically accompanied by hyperplasia and inflammation in the surrounding regions. It is crucial to identify cancer to provide correct treatments, but diagnosis needs to be done accurately and efficiently to avoid unnecessary biopsies which increase cost and risk

Dr. Sharmila Anandasabapathys research has led to the evaluation of advanced imaging technology for the detection of gastrointestinal cancer. Microendoscopy is a cost-effective detection method that easily gets inserted in the biopsy channel of an endoscope and provides 1000x magnification, allowing an optical biopsy of the affected tissue.

The use of augmented reality in cancer diagnosis and treatment is another way healthcare providers can stay connected to expert interpretation while operating in rural areas. In underdeveloped countries, the lack of screening and diagnostic technology makes it impossible for doctors to diagnose cancer growth at its early stage. According to Dr. Sharmila Anandasabapathy, the best way to cure cancer is to prevent cancer. Early diagnosis can help prevent cancer before it becomes advanced and incurable.

A researcher and a professor of Medicine in Gastroenterology at the Baylor College of Medicine in Houston, Sharmila Anandasabapathys work is invaluable for the medical sector. Her research papers and articles are published in notable journals. After getting her bachelors degree in English Literature from Yale University in 1993, she went to The Albert Einstein College of Medicine from where she graduated with an M.D degree with distinction in research in 1998.

After graduating with a doctor of medicine degree, she worked as an intern for four years at the New York-Presbyterian Hospitals Weill Cornell Medical Center and Memorial Sloan Kettering Cancer Center. In 2004, Sharmila went to Mount Sinai Medical Center, where she completed her gastroenterology fellowship and received advanced training in the endoscopic management of Barretts esophagus and esophageal cancer.

Currently, she is the Vice President and Director of Baylor Global Health, overseeing international programs focused on global healthcare capacity development and research. She is Chair of the AGA Womens Committee as well as Associate Editor of Gastrointestinal Endoscopy. Previously, she served as an attending physician at both Mount Sinai Medical Center and M.D. Anderson Medical Center. Her work is highly valued on a global level. She was listed as one of the most influential women in Houston and has been repeatedly ranked in the list of Super and Top doctors USA. Moreover, she is a featured USAID female innovator.

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INNOVATION IN HEALTHCARE MAKES MEDICAL TREATMENTS EFFICIENT AND ACCESSIBLE EFFORTS OF DR. SHARMILA ANANDASABAPATHY - RecentlyHeard.com