Category Archives: Stem Cell Doctors


Dad describes agonising moment son ‘foamed at mouth’ in ‘fatal allergic reaction’ – Mirror Online

A father has told of the agonising moment his son started foaming at the mouth before dying from a suspected allergic reaction after eating at a takeaway.

Chris Kelly, 44, claims son Nick, 16, turned blue and screamed I cant breathe, just minutes after taking a bite of a doner kebab he had ordered from Uno Pizzas in his hometown of Prescot, Merseyside, on March 7.

The dad-of-four said he and fiance Kim Clarke, 35, are going through absolute hell following the death of their son, who was in hospital for four nights on a ventilator before his death on Wednesday.

He passed away after doctors confirmed he was brain dead and there was nothing more they could do to keep him alive.

Chis said his youngest son was everyones best mate who would do anything to help anyone.

Merseyside Police has launched a joint investigation into Nick's death with Knowsley Council.

Stay-at-home dad Chris said: Nick walked home with his food and as soon as he took a bite he was running up the stairs screaming I cant breathe.

His mum tried to get his inhaler but Nick said no Im having a reaction so she started calling the ambulance.

The next minute she turned around and he was going blue in the face and foaming at the mouth.

"His brother gave him his epipen as soon as we realised what was happening but the doctors told us that the reaction was so severe it wouldn't have made a difference no matter how quickly we administered it.

Weve been going through absolute hell ever since.

Im still just waiting for him to come through the door and ask his mum whats for tea or ask me if he can have a bit of pocket money. It doesnt feel real."

After the teen fell to the floor unable to breath, Chris said Joe tried to resuscitate his brother for 10 minutes before paramedics arrived and Nick was rushed to Whiston Hospital in nearby Rainhill at around midnight.

The distraught family watched as medics at the hospital fought to get his heart pumping again but his body had been starved of oxygen and blood for at least an hour before his heart was restarted.

Doctors conducted a brain stem cell test and after finding no brain activity declared Nick officially deceased on Wednesday.

Chris said: There was no hope because his brain had been starved of oxygen and blood for an hour.

Nick was a happy lad just playing football and going out with his mates. He would help anyone he could and he would do anything for anyone, he was everybodys best mate.

He was getting ready to do his GCSEs and go to college to do an apprenticeship in engineering.

I cant believe hes gone.

Chris, who is also dad to Nicks older brother Joe, 17, and two sisters, Tiffany, 13, and Cheryl, 11, said they had known about their sons allergies since his first ever reaction at two-years-old.

Speaking about his son's first reaction, the dad added: "He had been sat in his high chair eating peanut butter sandwiches with his brother and Nicks lips swelled so big his top one was up to his nostril and his bottom was down to the bottom of his chin."

The investigation between Merseyside Police and Knowsley Council into Uno Pizzas is still ongoing as experts wait for samples to come back from the laboratory.

A spokesperson for Merseyside Police previously said: "We can confirm a joint Merseyside Police and Knowsley Council investigation has been launched after a 16-year-old boy fell ill in Prescot on Saturday, March 7, after consuming food from Uno Pizza, Prescot.

"Emergency services were called to Thomas Drive at midnight following reports the boy had collapsed after suffering a suspected allergic reaction.

"Enquiries are ongoing to establish the full circumstances and a cordon is in place at Uno Pizza, Chapel Street."

Uno Pizzas has been approached for comment.

Nicks family are raising money for the cost of his funeral in order to give him the best send off they can and have already received more than 1,100 in donations.

To donate, click here.

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Dad describes agonising moment son 'foamed at mouth' in 'fatal allergic reaction' - Mirror Online

Coronavirus tests stepped up to stop exodus of frontline NHS staff – HeraldScotland

Testingfor coronavirus will be ramped up amid criticism that NHS staff are being lost from the frontline over potentially harmless coughs, while private clinics report being inundated by people who can afford to pay for swab checks.

The Scottish Government says some Covid-19 testing on healthcare workers has already started at a local level anda national approach is being developed which will scale up these initial efforts.

It comes amid speculation that a new four-hour test could be made available in Britain.

Scotland reported its third coronavirus death on Wednesdayand First Minister Nicola Sturgeon confirmed schools across Scotland would close by the end of this week as a result of new advice from Government scientists.

They will also close in England, Wales and Northern Ireland.

Ms Sturgeon said many schools had reached a point where they have lost too many staff to continue as normal and would not necessarily reopen after Easter, or even before the summer holidays.

Prime Minister Boris Johnson said schools and nurseries across the UK would be expected to accommodate vulnerable children or the children of critical workers, such as NHS staff and police during the closure, with free school meals continuing to be provided to all eligible youngsters.

He added that exams would not go ahead as planned in May or June, but that pupils would get the qualifications they deserve.

Earlier Mr Johnson told the House of Commons the number of tests that can be carried out each day for coronavirus will be increased from 5,000 to 10,000, with a goal to expand it to 25,000 per day in England within four weeks.

North of the Border, there are three NHS laboratories currently processing tests and the Scottish Government is working with a range of partners to increase capacity to exceed 2,000 tests per day in the coming weeks.

A number of options to expand that further, and as quickly as possible, are being explored.

The Prime Minister said: We are prioritising testing of NHS staff for the obvious reason that we want them to be able to look after everybody else with confidence that theyre not transmitting the disease, and this country is actually far ahead of many other comparable countries in testing huge numbers of people.

It comes as a coronavirus test that reveals who has had Covid-19 but not shown symptoms is close to becoming available in a move being hailed as a game-changer.

The Governments chief scientific adviser, Sir Patrick Vallance, said Public Health Englands (PHE) work on the antibody test is progressing very fast, and will provide valuable insight into the pandemic.

Mr Johnson said: The great thing about having a test to see whether youve had it is suddenly a green light goes on above your head and you can go back to work safe and confident in the knowledge that you are most unlikely to get it again.

So for an economic point of view, from a social point of view, it really could be a game-changer.

You can really see the potential of that advance, which, as I say, is coming down the track.

Sir Patrick added: It is a gamechanger. And the reason its a gamechanger is that it allows you to understand the proportion of the asymptomatic population whos had this disease, but hasnt had symptoms.

Going forward its going to be critically important to be able to monitor this disease well because only by being able to monitor it can we start relaxing measuresagain.

The Scottish Government is increasing community surveillance by enabling 200 GP practices, representing a population of 1.2 million, to test patients for the virus.

Health Secretary Jeane Freeman has also promised to roll out testing to frontline NHS staff so that they do not self-isolate unnecessarily.

However, there has been criticism from medics that the process has been too slow and has left key services understaffed at a time when demand is soaring.

Glasgow GP Margaret McCartney tweeted: Our workload has increased 30-40 per cent in last two days.

I know everyone is very busy but a negative test in a symptomatic person would surely allow us to have a hope of functioning?

British Medical Association Scotland chairman Dr Lewis Morrison said: The impact Covid-19 will have on the NHS could be huge. Frontline workers will be working in very different ways and we will need every pair of hands we can possibly get at this time.

That is why it is essential for NHS staff to be tested for the virus if they suspect they have it.

The Scottish Government has assured us this will happen and we now need to see the details of how staff can access testing as soon as possible, to minimise the number of NHS staff who would otherwise be self-isolating.

Professor Michael Griffin, president of the Royal College of Surgeons Edinburgh, said: The recommendation from the UK Government on Monday that pregnant women should self-isolate, as well as a 14-day isolation of those who have been exposed to family members with symptoms, though understandable, has already put a huge pressure on the NHS workforce.

Thats why its absolutely imperative that healthcare workers are tested for Covid-19 to confirm whether they are infected in order to help prevent the unnecessary exclusion of essential NHS staff at the frontline when the epidemic hits its peak.

A test is available for 375 at the Private Harley Street Clinic in London.

Mark Ali, a doctor at the clinic, said it had been inundated with requests for the test, which can be couriered to and from a client for them to take swabs from their own nose and throat.

Mr Ali said: We are testing lords and ladies, knights, and even doctors and dentists who are worried about catching the disease.

As of March 12, the UK had tested just under 30,000 people more than any other European nation except Italy, which had tested 86,000 and Russia which had tested 80,000.

The US had tested fewer than 14,000 in official Centre for Disease Control (CDC) laboratories, compared to 250,000 in South Korea.

Scotland has carried out 6,091 tests to date. US firm ThermoFisher held talks this week with the Prime Minister, HealthSecretary Matt Hancock, Chief Medical Officer Chris Whitty, Chief Scientific Advisor Sir Patrick Vallance and representatives from Boots, Amazon and pharmaceutical giant Roche.

The firm is believed to have been demonstrating its four-hour testing kit which has been approved for use in the US.

The UK death toll from the virus has reached 104 exceeding 100 for the first time and the number of new cases is accelerating, with 676 new cases confirmed yesterday.

Organisers announced that the Glastonbury music festival and Eurovision Song Contest would not go ahead due to the coronavirus outbreak, with filming also suspended temporarily on BBC soaps including Eastenders and Casualty.

It comes as Chinas top coronavirus expert has warned that herd immunity will not contain the global pandemic because the disease is highly infectious and lethal.

Dr Zhong Nanshan, Chinas senior medical adviser, said: We dont yet have the evidence to prove that if you are infected once, you would be immune for life.

Clinical trials for potential vaccines are under way in China and the US, but is not expected to be ready until at least 2021.

Meanwhile, an antiviral drug used in Japan to treat influenza has shown potential to speed recovery from the novel coronavirus that causes Covid-19. The drug, called called Favipiravir or Avigan, was tested on 340 people in China who had been diagnosed with Covid-19.

Half tested negative for the virus within four days of being given the drug compared to 11 days for the patients not on the antiviral.

Lung conditions were also shown in X-rays to have improved in 91 per cent of participants.

There were also claims in China that patients could be cured using stem cell therapy.

Dr Dongcheng Wu, a doctor and stem cell expert based in Wuhan, the epicentre of the outbreak, said he had successfully treated nine patients who were hospitalised with novel coronavirus pneumonia.

All nine reportedly made a full recovery following stem cell transplants and conventional treatment. Dr Wu said: Yes, it is a cure but it is still very early in the process.

It came as Italy recorded 475 coronavirus deaths in a single day the highest 24-hour spike for any country since the infection emerged in China.

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Coronavirus tests stepped up to stop exodus of frontline NHS staff - HeraldScotland

Researchers and Doctors alike pursuing the field of stem cell research in treating heart attack survivors – Medical Herald

Key Takeaways:

The effects of myocardial infarction (heart attack) and congestive heart failure is a daunting task facing doctors and researchers alike. Heart attacks cause irreversible damage to the heart by weakening the heart muscle and making it less efficient in pumping blood through the circulatory system. It is noteworthy to remember that heart cannot take care of itself, meaning it has got minimum strength to regenerate whereby the untraceable muscle is replaced by a scar tissue. This leaves patients with a reduced cardiac role, which often leads to heart failure when the heart fails to accede to the demand placed upon it by the body in distributing blood. Current diagnosis treats the fallible symptoms such as low blood pressure but does not go to the seat of all problems. It is very well understood by this paradigm that heart is very reluctant and on second thoughts does not offer itself for being substituted for by the body.

Mayo Clinics are attributed with introduction of repairing heart attacks in individuals with aid of stem cells. Stem Cells restore cardiac muscle back to its original form meaning, the condition it was in before the heart attack, thus giving a roadmap to how the stem cells may function. Doctors at Mayo Research believe in the mouse model with the mouse prototype being an initial foray into advanced clinical trials in heart patients.

A study published in NPJ Regenerative Medicine digs out that human cardiopoietic cells present in the bone marrow mutate with defunct proteins to counter complex changes caused by a heart attack. The cardiopoietic cells are derived from stem cell sources of bone marrow.

The extent of transformation that a heart attack bears is too large for the heart attack to correct itself or to prevent any complexities from arising. However, cardiopoetic stem cell therapy induces change for the better partially or fully with minimum 85% of cellular functions promising to respond favourably to treatment. This was reiterated by Dr. Andre Terzic of Mayo clinics Center to Regenerative Medicine. He is senior author in this study.

Consecutive Heart Attacks leads to heart failure:

The heart muscles are sustained by an oxygen-rich blood flow to keep the heart pumping-contracting and expanding. However, during a heart attack, the arteries leading the blood flow are hindered by blockages in the artery. With no further outgo of blood, that area of the heart that is sourced by the artery begins to collapse involuntarily and a unhealthy scar tissue forms in the area. This could lead to a heart failure that eventually gives rise to heart failure.

A new insight into how stem cells repair the lifeless heart could pave the way to finding how stem cell therapy can help in the broader scheme of things.

The incisive insight in study of stem cells is lacking as to how it will rejuvenate other functional mechanisms, throwing light on the most intimate yet singularly comprehensive or regenerative mechanism in the body. Though customarily heart is considered to be a tough customer, it fails to pump blood as efficiently as it could from decapitated areas, and is the reason behind patients who have suffered a heart attack need to ingest a life-time of medicines to mitigate another heart attack and ensure its smooth functioning.

Heart Attack is the leading cause of death in the U.S as noted by Center for Disease Control and Prevention. The research additionally states that in a heart attack, the cardiac tissue dies involuntarily, thus weakening the heart.

The diseased heart responded to cardiopoeitic stem cell treatment with growth of blood vessels along with new heart tissue, so said Kent Arreli, Phd, Mayo Clinic Cardiovascular Researcher and first author of the study.

The Research: Leading the way

There is this research that delves upon the diseased hearts of mice that did not receive human cardiopoietic stem cell therapy with those that did. The result gave vent to the belief that more than 4000 cardiac proteins were present, 10 % of which suffered damages by a heart attack.

While we were always expecting a normal heart function after this study, the present outcome quite bewildered us where the diseased hearts shifted to and fro and came to rest on a healthy pre-diseased heart.

Cardiopoietic Stem Cells are being put to test in advanced clinical trials in heart patients.

It has been corroborated that current findings in stem cell therapy will bring some additional guidance and will steer therapeutic exercise in the near future.

Though it has to this point been proven, the fruitful remedies of stem cell therapies for heart failure, there are several unproven stem cell remedy experiments that are not still not ready to exercise in the real world.

A heart attack has been understood to happen when blood supply is cut-off to that portion of the heart muscle that causes irreparable damage and with time and many repeat attacks, a scar is formed resulting in a heart failure!

It is for over 2 decades that scientists have studied the positive benefits of stem cells which might repair a frail and damaged heart and restore it and these cell types can be made from other cells also coming as it does under the umbrella tern cardiac regeneration.

Cardiac Regeneration:

Cardiomyocites are highlighted here that are the beating muscle cells located in the chamber of the heart, Although scientists can grow cardiomycites in the lab from embryonic stem cells, growing them from the heart itself is showcasing itself plausibly.

Stem cells are inserted in the heart using a catheter. These stem cells are taken from the bone marrow and now that they are in place, they rejuvenate damaged heart tissues. There are pros and cons with this technique of insertion of stem cells into the heart. Having said that, it comes as no surprise when a donor who may be a stranger donates a stem cell which could be unacceptable to the body. But a positive point is that donor problems do not pose a big problem that helps the doctors to forge ahead relentlessly.

Long term effects are a bother still and more trials have to be conducted to probe the longevity question.

Though it comes as no surprise now with stem cells being delivered to the heart is possible and error-free, but the evidence is not noteworthy. There are 61 centers in all in the United States that accomplish the stem cell therapy to bring to life people with heart failure. These centers charge an estimated USD 7694 for a single treatment of autologous stem cells. ( from ones own body) which portrays a lot of scope with some 17 patients who were infused with stem cells taken from their own hearts to succeed in an unequivocal way.

Wrapping Up:

Two methods have come to light so far in passing stem cells into the body with one coming from external donors and the other being fed by ones own body. It has to be revealed still as to which method comes as more cogent in its delivery. When can one say with authority that stem cell therapy has come to stay? It is a few years down the line, some say with a view that it is work in progress and others are of the opinion that there is much work to be done.

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Researchers and Doctors alike pursuing the field of stem cell research in treating heart attack survivors - Medical Herald

Weston man builds epic motorcycle to promote saving lives through Be The Match donations – Wausau Daily Herald

Todd Euen of Johnstown, Pennsylvania, and Mark Ecklund of Weston stand behind the Be the Match motorcycle that Ecklund designed and built. Ecklund donated life-saving stem cells to Euen.(Photo: Photo courtesy of Mark Ecklund)

WESTON - It's a gleaming, curvy, sport-style motorcycle with a distinctArt Deco look, and there's no other bike like it on Earth.

Mark Ecklund of Weston took two years of painstaking, detail-oriented work to build it, hand-fabricating most of its body work from thin aluminum. For just the tail section, the 53-year-old machinist took two weeks to patiently and gently tap using a hand-held, hammer-like metal molding toolapiece of aluminum into the shape he wanted.

The project represents the ability to save lives. Mark created the motorcycle to honor and promote Be The Match, a worldwideorganization that works to matchdonors of life-saving bone marrow and stem cells to people suffering from blood cancers such a leukemia and lymphoma. In 2012, Mark donated stem cells that were used to save the life of a 53-year-old Pennsylvania man, who is a husband, father and grandfather.

Mark is a serial inventor who has built and designed things such as a one-person hovercraft, a safety faucet that prevents scaldingand an improved version of a compound bow, and it's his habit to enthusiastically andcompulsively throw himself into projects. But even for his standards, this motorcycle, once a brand-new Indian cruiser, is special.

A year after the transplant, Ecklund and the stem cell recipient, Todd Euen of Johnstown, Pennsylvania, met and became instant friends. The experience was so gratifying that Ecklund can't even begin to explain it. All he can say is that the motorcycle is a physical manifestation of those feelings, and a vehicle to promote Be The Match. He and his wife, Chris Ecklund,are doing anything they can to encourage people to register for Be The Match donations.

"We want to bring that awareness to people, to have more people register," Chrissaid.

The motorcycle is a work of art, Mark said, "that is more of a campaign."

Todd Euen and his family have grown close to Mark Ecklund and his wife, Chris. They posed for this portrait: Front row, left to right: Kaiden Miller (Todd's grandson), Khloe Miller (granddaughter), Rachael Euen (daughter) and Kylie Miller (granddaughter). Middle row, left to right: Amy Euen (Todd's wife); Emily Euen (daughter); Chris Ecklund. Back row: Erik Euen (son); Todd Euen; Mark Ecklund.(Photo: Courtesy of Todd Euen)

Todd, a controller at a Ford dealership, was diagnosed with leukemia in July 2012. In order to save his life, doctors rushed him to Pittsburgh, located about 66 miles west of Johnstown. If Todd hadn't gotten treatment, he likely would have died within two weeks, doctors told him.

"I was in shock," Todd said.

He received Mark's donation in a procedure done on Christmas Eve of 2012.

Be The Match requires that donors and recipients wait a yearafter procedures before connecting with each other. After that year passed, Todd contacted Mark to get to know him and thank him.

"I didn't know what to expect when I met him. He basically saved my life," Todd said. "It was real emotional when we met. ... Our family is forever grateful to him."

Mark Ecklund's motorcycle is etched with information about the Be The Match donor program.(Photo: Courtesy of Mark Ecklund)

Chris and Mark decided to become donors when Mark turned 35. They both regularly give blood, and it was Mark's idea to do more.

"We just wanted to help people," Mark said.

They found Be The Match, did a little research, and then, almost on a whim, drove to the Appleton office of Be The Match to register. Chris still hasn't been matched with a recipient.

"I'm really jealous of Mark," she said.

After meeting Todd , Mark came up with the idea to design and build the Be The Match motorcycle. He talked about his plans with Chris, and she agreed that they should purchase the 2015 Indian Scout to convert. Chrisdidn't quite grasp what her husband had in mind; she thought it would be a light modification of the new Indian model.

As Mark started to the project, "I thought, 'We spent all this money to tear it apart,'" Chris said.

Markvisualized his motorcycle from the start. "I knew exactly what I wanted. I knew exactly what I was going to do," he said.

He wanted something that would be magnetic to other motorcycle enthusiasts.And even though Chris didn't know the details, she's been married to Mark for 29 years. So she wasn't surprised when he spend nearly all his free time working on the bike. Nor was she surprised at the result.

They take the motorcycle to races and shows. First riders come see the bike, then Chris and Mark go into their Be The Match spiel, and often Chris will get people to register for donations on the spot. (It requires filling out a form and doing some cheek swabs to get DNA samples.)

Jess Klingberg, the Be The Match community engagement specialist based in Appleton, said the motorcycle is magnet for potential donors, helping sign up potential donors by the dozen. She attended a motorcycle rally with the Ecklunds. "That motorcycle turns a lot of heads," she said.

Todd accompanied Mark and Chris to one show near Pittsburgh, and even though he's gotten to know Mark and his all-in attitude, he was still surprised at how much gusto both Mark and Chris display when promoting Be The Match.

"They have jumped all in," Toddsaid with a laugh.

A live, over-the-air Radiothon for Be the Match will be held from 7 a.m. to 7 p.m. March 19 on the Wausau rock radio stationWIFC-FM 95.5Jess Klingberg, the Be The Match community engagement specialist who works in the organization's Appleton office, will be on air to explain details about the program and tell stories about what Be The Match can mean for individuals dealing with cancer.

Contact Keith Uhlig at 715-845-0651 or kuhlig@gannett.com. Follow him at @UhligK on Twitter and Instagram or on Facebook.

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Weston man builds epic motorcycle to promote saving lives through Be The Match donations - Wausau Daily Herald

2nd person cured of HIV thanks to stem cell transplant – Medical News Today

Researchers in the United Kingdom have confirmed that a stem cell transplant has cured a second person of HIV.

In 2007, Timothy Ray Brown became the first person ever whom doctors declared to be cured of HIV. At the time, they referred to him publicly as the Berlin patient.

His journey toward a cure was not straightforward. After having received an HIV diagnosis in the 1990s, Mr. Brown received antiretroviral treatment the usual course of action for an HIV infection.

However, later on, he also received a diagnosis of acute myeloid leukemia, for which he eventually required a stem cell transplant.

As he was looking for a suitable donor match, his doctor had the idea to try an experiment. He looked for a donor with a specific genetic mutation that made them practically immune to HIV.

Receiving stem cells from this donor, it turned out, not only treated Mr. Browns leukemia but also cured the HIV infection.

Now, as a study featuring in The Lancet shows, another person has officially been cured of HIV, also thanks to a stem cell transplant.

In this second case, the person received a stem cell transplant with cells that did not express the CCR5 gene, which produces a protein that helps the virus enter cells.

The cells without the CCR5 gene were part of a bone marrow transplant, which the person was undergoing as a treatment for Hodgkin lymphoma.

Following the transplant, and at 30 months after the person ceased antiretroviral therapy, doctors confirmed that the HIV viral load remained undetectable in blood samples.

This finding means that whatever traces of the viruss genetic material might still be in the system, they are so-called fossil traces, meaning that they cannot lead to further replication of the virus.

The specialists confirmed that HIV also remained undetectable in samples of cerebrospinal fluid, semen, intestinal tissue, and lymphoid tissue.

We propose that these results represent the second ever case of a patient to be cured of HIV, says the studys lead author, Prof. Ravindra Kumar Gupta, from the University of Cambridge in the U.K.

Our findings show that the success of stem cell transplantation as a cure for HIV, first reported 9 years ago in the Berlin patient, can be replicated.

Prof. Ravindra Kumar Gupta

However, Prof. Gupta emphasizes that [i]t is important to note that this curative treatment is high risk and only used as a last resort for patients with HIV who also have life threatening hematological [blood] malignancies.

Therefore, this is not a treatment that would be offered widely to patients with HIV who are on successful antiretroviral treatment, the researcher goes on to caution.

Commenting on these findings, other researchers involved in the study express the hope that, in the future, scientists may be able to use state-of-the-art gene editing tools as part of interventions meant to treat and cure HIV.

Dr. Dimitra Peppa, who is from the University of Oxford in the U.K. and co-authored the study, notes that [g]ene editing using the CCR5 has received a lot of attention recently.

Nevertheless, she points out, there is still a long way to go before such therapies may become viable.

There are still many ethical and technical barriers e.g., gene editing, efficiency, and robust safety data to overcome before any approach using CCR5 gene editing can be considered as a scalable cure strategy for HIV, she says.

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2nd person cured of HIV thanks to stem cell transplant - Medical News Today

Insights Into the $8.8 Billion Cell Therapy Industry, 2020-2027 – Rising Adoption of Regenerative Medicine, Introduction of Novel Platforms &…

DUBLIN, March 11, 2020 /PRNewswire/ -- The "Cell Therapy Market Size, Share & Trends Analysis Report by Use-type (Research, Commercialized, Musculoskeletal Disorders), by Therapy Type (Autologous, Allogeneic), by Region, and Segment Forecasts, 2020 - 2027" report has been added to ResearchAndMarkets.com's offering.

The global cell therapy market size is expected to reach USD 8.8 billion by 2027 at a CAGR of 5.4%, over the forecast period.

Cellular therapies hold a great therapeutic promise across various clinical applications. This has resulted in substantial global investments in research and clinical translation. Moreover, rapid advances in stem cell research hold the potential to fulfill the unmet demand of pharmaceutical entities, biotech entities, and doctors in disease management. These factors have boosted revenue growth for the market.

Currently, there are a limited number of FDA-approved commercial stem and non-stem cell therapies in the market. Furthermore, LAVIV (Azficel-T), manufactured and commercialized by Fibrocell Technologies, witnessed revenue wind-down in the past years. Key developers are making substantial investments in the adoption of advanced technologies to address the aforementioned challenges.

The introduction of proprietary cell lines is recognized as the primary means by which a single cell can be exploited for the production of a robust portfolio of candidates. Companies are leveraging new technologies not only for the expansion of their product portfolio but also for establishing out-licensing or co-development agreements with other entities to support their product development programs.

For instance, MaxCyte has more than 40 high-value cellular therapy partnership programs within immune-oncology, regenerative medicine, and gene editing, including fifteen clinical-stage programs. Increase in the number of collaborations between entities for product commercialization is anticipated to accelerate market revenue to a major extent in the coming years.

In Asia-Pacific, the market is anticipated to witness significant growth over the forecast period. This is attributed to rising awareness cellular therapies among patients and healthcare entities in chronic disease management. In addition, availability of therapeutic treatment at lower prices is also driving the regional market. Japan is likely to witness fast growth over the forecast period attributed to increasing research activities on regenerative medicine.

Further key findings from the report suggest:

Key Topics Covered

Chapter 1 Executive Summary

Chapter 2 Research Methodology

Chapter 3 Cell Therapy Market Variables, Trends & Scope3.1 Market Segmentation & Scope3.1.1 Market driver analysis3.1.1.1 Rise in number of clinical studies pertaining to the development of cellular therapies3.1.1.2 Rising adoption of regenerative medicine3.1.1.3 Introduction of novel platforms and technologies3.1.2 Market restraint analysis3.1.2.1 Ethical concerns related to stem cell research3.1.2.2 Clinical issues pertaining to development & implementation of cell therapy3.1.2.2.1 Manufacturing issues3.1.2.2.2 Genetic instability3.1.2.2.3 Stem cell culture condition3.1.2.2.4 Stem cell distribution after transplant3.1.2.2.5 Immunological rejection3.1.2.2.6 Challenges associated with allogeneic mode of transplantation3.2 Penetration & Growth Prospect Mapping For Therapy Type, 20193.3 Cell Therapy Market (Stem & Non-stem Cells)-Swot Analysis, by Factor (Political & Legal, Economic and Technological)3.4 Industry Analysis - Porter's3.5 Cell Therapy Market (Stem & Non-stem Cells)-Regulatory Landscape

Chapter 4 Cell Therapy Market (Stem & Non-stem Cells) Categorization: Use-type Estimates & Trend Analysis4.1 Cell Therapy Market (Stem & Non-stem Cells): Use-type Movement Analysis4.2 Clinical-use4.3 Research-use

Chapter 5 Cell Therapy Market (Stem & Non-stem Cells) Categorization: Therapy Type Estimates & Trend Analysis5.1 Cell Therapy Market (Stem & Non-stem Cells): Therapy Type Movement Analysis5.2 Allogeneic Therapies5.3 Autologous Therapies

Chapter 6 Cell Therapy Market (Stem & Non-stem Cells) Categorization: Regional Estimates & Trend Analysis, by Product6.1 Cell Therapy Market (Stem & Non-stem Cells) Share by Regional, 2019 & 20276.2 North America6.3 Europe6.4 Asia-Pacific6.5 Latin America6.6 MEA

Chapter 7 Competitive Landscape7.1 Strategy Framework7.2 Company Profiles7.2.1 Kolon TissueGene, Inc.7.2.2 JCR Pharmaceuticals Co. Ltd.7.2.3 MEDIPOST7.2.4 Osiris Therapeutics, Inc.7.2.5 Stemedica Cell Technologies, Inc.7.2.6 Cells for Cells7.2.7 NuVasive, Inc.7.2.8 Fibrocell Science, Inc.7.2.9 Vericel Corporation7.2.10 Pharmicell Co. Ltd.7.2.11 Anterogen Co. Ltd.7.2.12 Celgene Corporation

For more information about this report visit https://www.researchandmarkets.com/r/ma559h

Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.

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Research and Markets Laura Wood, Senior Manager press@researchandmarkets.com

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Insights Into the $8.8 Billion Cell Therapy Industry, 2020-2027 - Rising Adoption of Regenerative Medicine, Introduction of Novel Platforms &...

Second HIV Patient Reportedly ‘Cured’ – HealthDay

MONDAY, March 9, 2020 (HealthDay News) -- It was 12 years ago that a German patient was seemingly cured of HIV. Now doctors in the United Kingdom believe they've finally duplicated that success, this time in a 40-year-old Englishman.

Adam Castillejo was known until recently only as the "London patient." Now, after surviving years of grueling treatments, he says he sees himself as an "ambassador of hope" for others.

Although his doctors publicly describe his case as a long-term remission, experts in interviews have called it a cure for the AIDS-causing virus, according to a report in The New York Times.

"This will inspire people that cure is not a dream," said Dr. Annemarie Wensing, a virologist at the University Medical Center Utrecht in the Netherlands. "It's reachable," she told the Times. Wensing is also co-leader of IciStem, a group of scientists studying stem cell transplants to treat HIV.

Like Timothy Ray Brown, his predecessor, Castillejo was getting treatment for a blood cancer (Castillejo had Hodgkin's lymphoma; Brown had leukemia). Both underwent bone-marrow transplants designed to beat the cancer, not the HIV.

In both cases, the critical transplant was from a donor with a mutation in the CCR5 protein. The Times explained that HIV uses the protein to enter certain immune cells but cannot latch on to the mutated version. In other words, the donor was HIV-resistant.

Castillejo's transplant was in May 2016. He has been off anti-HIV drugs since September 2017. He and Brown are the only patients known to have stayed HIV-free for more than a year after quitting the drugs.

To be cured of both cancer and HIV was "surreal," Castillejo told the newspaper. "I never thought that there would be a cure during my lifetime."

Details of the new case, to be published March 10 in Nature, were scheduled for presentation at this week's Conference on Retroviruses and Opportunistic Infections, in Seattle.

Brown, whose case was described in 2007, is now 52 and living in Palm Springs, Calif. He was far sicker after his procedures than Castillejo, and nearly died.

One of the U.K. doctors, Dr. Ravindra Gupta of University College London, called the new case a game-changer. "Everybody believed after the Berlin patient that you needed to nearly die basically to cure HIV, but now maybe you don't," Gupta told the Times.

Transplants are dangerous and may not be a realistic treatment right now. But experts say the new "cure" may pave the way for related but more practical immune cell-modifying approaches.

There are no guarantees that Castillejo's remission will persist, but Gupta said the indications are good since there are so many similarities with Brown's recovery.

Brown, meanwhile, said he is rooting for Castillejo. "If something has happened once in medical science, it can happen again," Brown said. "I've been waiting for company for a long time."

More information

The U.S. National Library of Medicine has more about living with HIV.

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Second HIV Patient Reportedly 'Cured' - HealthDay

Cancerous tumors, surrounding cells illuminated by new imaging agent – Washington University in St. Louis Newsroom

Scientists at Washington University School of Medicine in St. Louis have developed a new imaging agent that could let doctors identify not only multiple types of tumors but the surrounding normal cells that the cancer takes over and uses as a shield to protect itself from attempts to destroy it.

The study appears March 9 in the journal Nature Biomedical Engineering.

The imaging agent, referred to as LS301, has been approved for investigational use in small clinical trials atSiteman Cancer Centerat Barnes-Jewish Hospital and Washington University School of Medicine. The first trial will investigate its use in imaging breast cancer.

This unique imaging agent identifies cancer cells as well as other compromised cells surrounding the tumor, saidSamuel Achilefu, the Michel M. Ter-Pogossian Professor of Radiology. Cancer transforms surrounding cells so that it can proliferate, spread to other parts of the body and escape treatment. This imaging compound can detect cancer cells and their supporting cast, the diseased cells that are otherwise invisible.

The compound binds to the activated form of a protein called annexin A2, which is present in many types of solid tumors but not healthy tissue. The activated form of the protein promotes inflammation and invasiveness of these tumors, which allows the cancer to spread.

Solid tumors that contain activated annexin A2 are found in breast, colon, liver, pancreatic, head and neck, and brain cancers. Since the activated form of the protein also is present in the cells that surround the tumor and not normal, healthy cells doctors potentially could use this imaging agent to identify cells the tumor has hijacked. Despite their benign status, these hijacked cells protect the tumor from chemotherapy, radiation and other attempts to kill the cancer cells. Such co-opted cells also conceal cancer stem cells, whose stealth presence can lead to a recurrence of the tumor.

We are coming to the realization that to eradicate cancer, we also need to focus on the microenvironment of the tumor, said Achilefu, who also directs the universitysOptical Radiology Labat theMallinckrodt Institute of Radiologyand is co-leader of the Oncologic Imaging Program at Siteman. Most cancer drugs are designed to target cancer cells. But cancer cells create their own fiefdom, where they impose their own rules. If a normal cell nearby wants to continue living, it must follow the new rules. And slowly these cells come to identify with the tumor rather than their normal identity.

Achilefu expects that with a tumor and its surrounding fiefdom illuminated by the new imaging agent, doctors would have a better chance of removing the entire tumor as well as any areas that are likely to harbor microscopic cancer cells. In past work, Achilefus team has developed cancer goggles that allow surgeons to visualize cancer cells in real time during surgery to remove a tumor. The new imaging agent can be used with these goggles, which are being evaluated in clinical trials. The researchers also are working on a version of the compound that could be used in positron emission tomography (PET) scans, which many cancer patients undergo to assess whether cancer has spread.

As Achilefu and his colleagues saw that the compound lit up the hijacked cells on the periphery of the tumor, they were surprised to see the imaging agent light up parts of the central core of the tumor as well.

We were amazed when we saw this because its extremely difficult to access anything inside a tumor, Achilefu said. There seems to be a type of immune cell that carries the imaging agent into the core of the tumor. So we now see the tumor margin and the core light up. This allows us to imagine a situation in which we could deliver a drug to the outside and the inside of the tumor at the same time. This dual targeting is not something we purposefully designed its not something we ever anticipated.

With this in mind, Achilefus team conducted mouse studies to show that the researchers can attach a chemotherapy drug to the compound and use it to image the tumor and treat the disease simultaneously.

Attaching a chemotherapy drug to this targeted imaging agent could reduce side effects as we are delivering the drug directly to the tumor, he said. If the clinical trials are successful with the imaging, we will move into therapy.

Originally published by the School of Medicine

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Cancerous tumors, surrounding cells illuminated by new imaging agent - Washington University in St. Louis Newsroom

Low back and neck pain is costing us a fortune. Here’s how to stop – jacksonprogress-argus

If you're constantly seeking relief for bothersome back and neck pain, you're likely not alone, according to a study published Tuesday in JAMA.

In 2016, Americans and their insurance companies spent an estimated $134.5 billion on lower back and neck pain -- more than all forms of cancer combined.

Researchers estimated US public, private and out-of-pocket spending on health care for 154 health conditions from 1996 to 2016 and low back and neck pain was first, followed by other musculoskeletal conditions including joint and limb pain, then spending for diabetes, heart disease, falls and urinary diseases.

"In terms of health and wellness, I think the study highlights [that] a lot of the issues could be prevented with proper wellness and nutrition balance in our lives," said Dr. Sheldon Yao, chair and professor of Osteopathic Manipulative Medicine at the New York Institute for Technology's College of Osteopathic Medicine. Yao was not part of the study.

Drivers of back and neck pain

Back pain can be debilitating, removing people from enjoying the activities of everyday life. This area of the body is composed of complex system of muscles, ligaments, tendons, disks and bones, which all coordinate to support the body.

Obesity, sedentary lifestyles, technology and poor diet have all been linked to back and neck pain.

"Obesity is a giant epidemic that plays a part into back pain," Yao said, explaining that a loss of core strength due to obesity can put someone at increased risk for back pain.

Poor posture and a lack of core- and neck-strengthening exercises -- such as planks, neck-tilts, yoga and lifting weights -- also contribute to increased incidence of low back and neck pain, because weak muscles fail to properly support bones and are more prone to injury.

The amount of time a person spends sitting at their desk or bending over their cell phone can also be to blame.

"Everyone's on their smart phone now, constantly connected 24/7 and your posture is just looking forward," Yao said. The strain on a person's spine from constantly bending one's neck to text or browse can feel like the equivalent of 20 or 30 pounds, according to a 2018 study.

"Those are things where, as a society, we are not balanced," Yao said. "I'm not saying you can't eat any of those things, but just be aware of how much we're taking in in terms of those inflammatory foods."

How to alleviate pain at home

Health care spending on neck and back pain has increased each year since 1996, the study found, including newer and more expensive treatments such as stem cell and plasma injections, and an increase in surgeries instead of outpatient treatment.

The dollars don't appear to be well-spent, said Dr. Joseph Dieleman of the Institute for Health Metrics and Evaluation at the University of Washington's School of Medicine.

"The big picture trend suggests that all of the spending isn't essentially leading to fewer cases," said Dieleman, lead author of the study.

"In fact, we see that the health burden essentially hasn't changed at all over time, despite the huge increases in spending," he said. "It suggests that we have increased our spending a huge amount but we're not necessarily getting a lot more for it."

There are ways to mitigate back and neck pain at home before it becomes a larger problem.

It might seem counterintuitive, but staying moderately active by going for a walk can help reduce pain and prevent muscles from weakening.

"One of the biggest misconceptions is, 'I hurt myself. I need to go on complete bed rest and lie in bed and do nothing,' " Yao said. "That's been shown to really not be effective and ideally they need to try to maintain some form of activity as much as they can, and that's been shown to have positive results."

Eating healthier can not only reduce the inflammation that can lead to chronic back pain; it can also help someone lose excess weight, another factor of back pain.

Chronic back pain can be emotionally straining in addition to the physical symptoms.

To manage frustration, depression and other psychological side effects, Johns Hopkins Medicine recommends mindfulness and meditation as two nonsurgical methods for easing back pain. Taking breaks from activity when needed and being patient with yourself can prevent the condition from advancing.

Lower back pain can stem from a range of causes, from a mild strain to a traffic accident. If pain becomes something more serious, it's important to seek additional care from a doctor instead of self-medicating, Yao said. Doctors can recommend multiple treatments including muscle relaxants, injections and physical therapy.

Yao said the study highlights the extent to which society as a whole can improve on their muscle and joint health and ensure that patient care is at the forefront.

"Exercise is the last thing we do, eating right is the last thing we do," Yao said. "Society as a whole is so stressed and overworked and taxed out that health becomes really on the back burner.

"Patients have to take care of and responsibility for their own health. The more that a doctor can help facilitate that, the better."

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Low back and neck pain is costing us a fortune. Here's how to stop - jacksonprogress-argus

Ethan Zohn Talks Survivor: Winners at War and Life After Cancer – menshealth.com

Survivor fans have been waiting for an all-winners season of the hit CBS show for a very long time, and when the official cast list for Survivor: Winners at War was finally released, everyone was excited to see Ethan Zohn's name among the list of returnees. With his positive attitude, he quickly became a fan favorite when he played (and won) Survivor: Africa back in 2002, and when he later appeared on Survivor: All-Stars in 2004.

Zohn's been busy in the 16 years between All-Stars and Winners at War, from the nonprofit organization he co-founded to his appearance on The Amazing Race in 2011. Zohn played professional soccer prior to Survivor, and after the show, he reported for ESPN during the 2002 FIFA World Cup. Zohn has also been open about his post-show health struggles, as he battled a rare type of cancer called CD20-positive Hodgkin's lymphoma in 2009 and 2011. In 2012, Zohn received two stem cell transplants from his brother, and he's been in remission ever since.

While Zohn started off strong on Winners of War by forming an alliance with big-name players, he ended up getting majorly blindsided on the season's fourth episode, and it also looks like he might be in some trouble during tonight's episode. Zohn spoke with Men's Health about his time on the show, how he prepped for his long-awaited return, and how his experience on the Edge of Extinction paralleled his battle with cancer.

This interview has been edited and condensed for clarity.

"I had no idea whatsoever that I was about to be voted off that night. Definition of blindside ... I had a good thing going with my alliance (Rob and Parvati), and I had a little side thing going with Adam, and so when Adam revealed the plan to go against Parvati, we were just like, 'Uhh no,' because both Rob and I were working with Parvati, more than Adam. So we had to switch the script and go after Adam and it backfired for a lot of different people, most importantly me."

"I was so discombobulated. Watching it back is actually fun for me, because it was such a blur ... Once I saw my name the second time up there, I was like, 'This is the end for me.' I had put in a lot of time and energy and motivation in getting ready to go play the game. And after 16 years, two cancer diagnoses, for me to get to the starting point was such a huge, huge deal. I dont think people understand the complexity of my health challenges leading up to this point. So to be kicked off early and get sent to the Edge of Extinction was very disappointing, I had very high expectations for myself. I'm a former professional soccer player, a marathoner, an athlete and I like to win, so I would have liked to play the game of Survivor. The Edge of Extinction, we get to play but its a different game."

"I like to think that Im generally positive. I think whats interesting about the Edge of Extinction is that its this weird world between life and death. So I think the parallels between living on the Edge of Extinction and going through cancer is kind of similar. Youre here on this island, youre caught between life in the game and life out of the game, youre isolated from your friends and family, youre tired youre hungry, youre thirsty, youre lethargic."

"But the incredible thing about the Edge of Extinction is that you may have a couple chances to get back into the game, and that was all I needed. All you need is a tiny bit of hope. And that hope can come in a multitude of different ways: winning challenges, fire tokens, other ways to get back in the game. With cancer there is a clear parallel. You gotta just stay alive long enough because you just never know whats around the corner. A new cure, a new drug, cancer research, whatever it is. But as long as you keep that hope alive, theres a way out of this thing."

"I was extremely excited as you can imagine, but I was also like, 'I have to get off the couch and start getting into shape again.' I was so excited, I knew this probably going to happen at some point in my life, that there was going to be an all-winners edition. And I remember, I was literally in my second stem transplant watching Heroes vs. Villains, and I was fairly confident that I would have been asked to play that season if I hadnt been sick. So here I am, literally surviving for my life here in this hospital room watching my friends play another game, and I would have done anything to be out there, because to me that represents adventure and life and health. Being a healthy person in this world to me, is going out there and being able to compete at the highest level in a game that touches you physically, mentally, socially, spiritually, environmentally. And so I was like if I get out of this thing alivewhich I had a 50% shot ofthen Im going to do everything in my power to get myself ready to go play this game again."

"Yes. I was completely dumbfounded to see Amber out there. They had separated us prior to the game as boys and girls, and then we get out there and we see the women show up. I expected that, but then I saw Amber. I was standing next to Rob and I tapped him on the back and was like, 'Hey dude, you got your wife out here? Well done, well played.'"

"I was researching on the internet pretty heavily, and there was a lot of fan theories and fans analyzing for us, and I love when people do that [laughs]. I was watching all the seasons of the people that I thought might be in there."

"Parvati and I are friends outside of the game so we definitely spoke, but other than that I didnt speak to anyone ... Theres a lot of activity with the new schoolers now. They go to parties, charity events, social media-ing. So theres a lot of pre-existing relationships that I think may or may not have played a factor in the game. But thats not part of my game. When you get to the island the game starts, thats when the game starts."

"I live in New Hampshire, so when I got the call, there was snow up to my thighs outside. So my wife [interior designer Lisa Heywood] and I left New Hampshire, packed the house, moved to a ridiculously amazing health and wellness community called Serenbe near Atlanta so I could be outside and train and light fires. My wife was hiding idols in the forest for me, I was tying and untying knots, doing puzzles.

"Im playing 16 years of catch up, and the game is moving at a rocket pace, and I am used to game where ... there was no idols, there were no clues, there was no way to get back in the game, no fire tokens or currency, no Edge of Extinction, nothing. So I really had to play a lot of catch up and get used to this new gameplay and I just tried to do the things that I could.

"I read some body language books and some lip reading stuff. I really took this seriously, but it may not have looked it, because I got voted off on the fourth episode [laughs]. But I thought if Im really going to do this and this is my last hurrah and Im going to win this money, then I have to put in the time and effort."

"I hired Aaron Leventhal, hes the strength and conditioning coach for the Minnesota Thunder. Hes also a former professional soccer player and we played together back in the day. So I hired him to give me a training plan, an eating plan, everything.

"This time, I really focused on eating. I cut out coffee, sugar, I stopped using cannabis. So that was a big thing for me because I use CBD everyday and cannabis is part of my recovery from going through cancer and dealing with all the anxiety. I started going to bed when the sun went down, I tried to rise when the sun came up. I did everything I could to get myself on a cycle and on a system where my body wasnt going through shock.

"I actually asked the Survivor doctors if I could bring it out there, because I use it as a medicine, and its not illegal in all states. But its illegal in Fiji!"

"Cancer is fairly easy to go throughwhen the doctor tells you to do something or youre going to die, you pretty much do it, you dont have any choice. But with surviving cancer and being a young adult with this whole world in front of you, thats when it really gets tough. Theres uncertainty, theres scars that need healing, you dont know if the cancer is going to come back. There's anxiety that your whole life is going to be different, whos going to want to marry you, am you going to have kids, can you get a job or health insurance.

"All that stuff is just going through your head on a daily basis and I just got sucked into that life of fear and anxiety and it was hard for me to break out of that. But then I finally did and now I have to go on Survivor and be away from everything. I had gotten to a point in my life where everything was all good, so that was really difficult for me to be honest, behind the scenes. I might look calm and collected out there, but on the inside I was...it was war of the worlds going on.

"I became an investor in a farm in upstate Vermont thats called MontKush, and we produce certified organic, high altitude outdoor hemp. I actually have a line of CBD tinctures that will be coming out in the summer. Theres also a TV show coming out that's going to be about the farm, and the leads are Anthony Sullivan from OxiClean and Dave Christian [Ed: Zohn will also appear on the show, but he won't be a main character]. I moved up there this past summer when I got back from Survivor and I lived on the farm and did everything a farmer would do."

"Lets put it this way: I would like to see an old schooler win this game."

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Ethan Zohn Talks Survivor: Winners at War and Life After Cancer - menshealth.com