Category Archives: Stem Cell Medicine

PUBLIC RELEASE DATE:

9-Oct-2014

Contact: Mark Wheeler mwheeler@mednet.ucla.edu 310-794-2265 University of California - Los Angeles @uclanewsroom

People with autism spectrum disorder often experience a period of accelerated brain growth after birth. No one knows why, or whether the change is linked to any specific behavioral changes.

A new study by UCLA researchers demonstrates how, in pregnant mice, inflammation, a first line defense of the immune system, can trigger an excessive division of neural stem cells that can cause "overgrowth" in the offspring's brain.

The paper appears Oct. 9 in the online edition of the journal Stem Cell Reports.

"We have now shown that one way maternal inflammation could result in larger brains and, ultimately, autistic behavior, is through the activation of the neural stem cells that reside in the brain of all developing and adult mammals," said Dr. Harley Kornblum, the paper's senior author and a director of the Neural Stem Cell Research Center at UCLA's Semel Institute for Neuroscience and Human Behavior.

In the study, the researchers mimicked environmental factors that could activate the immune system such as an infection or an autoimmune disorder by injecting a pregnant mouse with a very low dose of lipopolysaccharide, a toxin found in E. coli bacteria. The researchers discovered the toxin caused an excessive production of neural stem cells and enlarged the offspring's' brains.

Neural stem cells become the major types of cells in the brain, including the neurons that process and transmit information and the glial cells that support and protect them.

Notably, the researchers found that mice with enlarged brains also displayed behaviors like those associated with autism in humans. For example, they were less likely to vocalize when they were separated from their mother as pups, were less likely to show interest in interacting with other mice, showed increased levels of anxiety and were more likely to engage in repetitive behaviors like excessive grooming.

Brain Repair 'May Be Boosted By Curry Spice'

By adminSeptember 29, 2014Stem Cell Medicine

A spice commonly found in curries may boost the brain's ability to heal itself, according to a report in the journal Stem Cell Research and Therapy.

The German study suggests a compound found in turmeric could encourage the growth of nerve cells thought to be part of the brain's repair kit.

Scientists say this work, based in rats, may pave the way for future drugs for strokes and Alzheimer's disease.

But they say more trials are needed to see whether this applies to humans.

Spice injection

Researchers from the Institute of Neuroscience and Medicine in Julich, Germany, studied the effects of aromatic-turmerone - a compound found naturally in turmeric.

Rats were injected with the compound and their brains were then scanned.

Particular parts of the brain, known to be involved in nerve cell growth, were seen to be more active after the aromatic-turmerone infusion.

Scientists say the compound may encourage a proliferation of brain cells.

In a separate part of the trial, researchers bathed rodent neural stem cells (NSCs) in different concentrations of aromatic-tumerone extract.

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Brain Repair 'May Be Boosted By Curry Spice'

Common Curry Ingredient Could Help The Brain Battle The Affects Of Alzheimers

By adminSeptember 28, 2014Stem Cell Medicine

September 27, 2014

Chuck Bednar for redOrbit.com Your Universe Online

Eating spicy Indian food could help boost the brains ability to heal itself, according to new research published in Fridays edition of the journal Stem Cell Research and Therapy.

According to Damian Gayle of The Daily Mail, aromatic turmerone, a compound found in the popular curry spice turmeric, could encourage the growth of nerve cells believed to help repair the brains of those suffering from neurodegenerative conditions such as dementia or Alzheimers disease.

In lab tests involving rats, researchers from the Institute of Neuroscience and Medicine (INM-3) in Germany, the University Hospital of Cologne Department of Neurology and the Max Planck Institute for Neurological Research found that aromatic turmerone promoted the proliferation of brain stem cells and their development into neurons.

The study authors believe it could help scientists develop new ways to treat conditions that kill brain cells, which include strokes and Alzheimers. However, they told BBC News health reporter Smitha Mundasad that additional trials are required to see if the affect is applicable to humans.

The researchers injected the rodents with the compound, and then scanned their brains, Mundasad explained. They found that activity increased in the regions of the brain known to be involved in nerve cell growth following infusion with the bioactive compound. Specifically, they found that the subventricular zone (SVZ) was wider and the hippocampus had expanded in the brains of rats injected with aromatic turmerone.

In a different part of the trial, the researchers bathed rodent neural stem cells (NSCs) in different concentrations of aromatic tumerone extract. NSCs are stem cells found within adult brains that differentiate into neurons, and play a vital role in the self-repair and recovery of brain function in neurodegenerative diseases, the authors explained.

Rat fetal NSCs were cultured and grown in six different concentrations of aromatic tumerone during a 72-hour period, and at some concentrations, the compound was shown to increase stem cell proliferation by as much as 80 percent without having any impact on cell death. Furthermore, the cell differentiation process also became accelerated in cells treated with the aromatic tumerone compound when compared to untreated controls.

In a statement, lead author and INM-3 researcher Dr. Maria Adele Rueger said, While several substances have been described to promote stem cell proliferation in the brain, fewer drugs additionally promote the differentiation of stem cells into neurons, which constitutes a major goal in regenerative medicine. Our findings on aromatic turmerone take us one step closer to achieving this goal.

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Common Curry Ingredient Could Help The Brain Battle The Affects Of Alzheimers

Cell Isolation/Cell Separation Market Worth $5.1 Billion by 2019

By adminSeptember 24, 2014Stem Cell Medicine

DALLAS, September 24, 2014 /PRNewswire/ --

According to the new market research report "Cell Isolation/Cell Separation Marketby Product (Reagent, Media, Bead, centrifuge), Cell Type (human, stem cell, animal), Technique (Filtration, Surface Marker),by Application (Research, IVD) &by End user (Hospital, Biotechnology) - Forecast to 2019", published by MarketsandMarkets, provides a detailed overview of the major drivers, restraints, challenges, opportunities, current market trends, and strategies impacting the Cell Isolation Market along with the estimates and forecasts of the revenue and share analysis.

Browse 194 market data tables and 53 figures spread through 211 pages and in-depth TOC on"Cell Isolation/Cell Separation"

http://www.marketsandmarkets.com/Market-Reports/cell-isolation-market-103931479.html Early buyers will receive 10% customization on this report.

The global Cell Isolation Market is expected to reach $5.1 Billion by 2019 from $2.5 Billion in 2014, growing at a CAGR of 15.8% from 2014 to 2019.

The report segments this market on the basis of product, cell type, technique, application, and end user. Among various techniques, the centrifugation-based cell isolation technique is expected to account for the largest share in 2014, while surface marker-based cell isolation technique is expected to account for the fastest-growing segment in the cell isolation market, owing to technological advancement due to which new products are being launched in the market. Furthermore, rising usage of surface market-based cell isolation techniques in stem cell and cancer research is another major reason for the growth of this market.

Based on geography, the global Cell Isolation Market is segmented into North America, Europe, Asia, and Rest of the World (RoW). North America is expected to account for the largest share of the market by the end of 2014. The large share of this region can be attributed to various factors including increasing government support for cancer and stem cell research and expanding biotechnology and biopharmaceutical industries in this region.

Further Inquiry:http://www.marketsandmarkets.com/Enquiry_Before_Buying.asp?id=103931479

Prominent players in the Cell Isolation Market are BD Biosciences (U.S.), Danaher Corporation (U.S.), GE Healthcare (U.K.), Merck Millipore (U.S.), Miltenyi Biotec (Germany), pluriSelect (U.S.), STEMCELL Technologies (Canada), Sigma-Aldrich Corporation (U.S.), Terumo BCT (U.S.), and Thermo Fisher Scientific, Inc. (U.S.).

Browse related reports

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Cell Isolation/Cell Separation Market Worth $5.1 Billion by 2019

Germantown's Next Healthcare pairs with NFL player

By adminSeptember 22, 2014Stem Cell Medicine

Company plans for the future of stem cell use

by Samantha Schmieder

Staff Writer

Next Healthcare Inc. of Germantown recently launched a partnership with Arizona Cardinals wide reciever Larry Fitzgerald to promote its newest venture, CelBank Pro to other professional athletes.

Next Healthcares CelBank is the collection of cell samples and storage of their blood, skin or stem cells to be used in the future. Stem cells are unspecialized cells that are able to renew themselves through cell division and can be scientifically manipulated to become another type of cell with a more specialized function. They offer hope to provide new ways to fight disease or injuries, according to the National Institutes of Health.

Essentially we are in the business of banking cells for people, Vin Singh, the founder and CEO of Next Healthcare, said.

While CelBank is geared toward anyone interested in using their own cells later in their life, CelBank Pro is geared toward sports players who are very likely to get injured or just worn down during their career.

Skin cells and stem cells are stored at a healthy time at someones life for later use in regenerative medicine, Singh said.

In 2006 and 2007, Singh, who lives in Boyds, heard about a method in Japan that was able to turn adult skin cells into stem cells. Singh decided to build Next Healthcare around these induced pluripotent stem cells, or iPS cells.

For me that was the real spark. I heard about that and thought, Wow, this is an amazing, revolutionary breakthrough, Singh said. Thats where the idea came from, what can we do with that technology. There has to be something that I can do for consumers to give them an advantage.

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Germantown's Next Healthcare pairs with NFL player

Germantown

By adminSeptember 22, 2014Stem Cell Medicine

Company plans for the future of stem cell use

by Samantha Schmieder

Staff Writer

Next Healthcare Inc. of Germantown recently launched a partnership with Arizona Cardinals wide reciever Larry Fitzgerald to promote its newest venture, CelBank Pro to other professional athletes.

Essentially we are in the business of banking cells for people, Vin Singh, the founder and CEO of Next Healthcare, said.

Skin cells and stem cells are stored at a healthy time at someones life for later use in regenerative medicine, Singh said.

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Germantown

Bone paste could provide treatment for ostoeporosis …

By adminSeptember 21, 2014Stem Cell Medicine

About three million Briton currently suffer osteoporosis which is affected by a number factors such as genes, a lack of exercise and poor diet and results in about 60,000 hip, 50,000 wrist and 120,000 spinal fractures every year, according to the National Osteoporosis Society, costing about 1.7 billion in health and social care.

Dr Ifty Ahmed, a researcher at Nottingham University, said his team wanted to provide a preventative treatment, strengthening the bones of those at risk before they suffered a fracture.

Speaking at the Regener8 conference on regenerative medicine, in Leeds last week, he said: Our aim would be to use screening to spot people who are at risk, then strengthen their bones before they get fractures.

It means that rather than waiting until people have a fall and break something, we would try to stop that ever happening, along with the consequences, loss of independence, surgery and secondary illnesses.

Previous attempts have been made to find ways of strengthening thinning bones but the difficulties of protecting the fragile stem cells has meant no such treatments have yet been developed.

Dr Ahmeds team hope to overcome this problem by puncturing the tiny hollow spheres of calcium phosphate allowing the stem cells to migrate inside them where they are protected.

The experimental treatment has not yet been trialled on humans.

It would involve extracting stem cells from a patients bone marrow and mixing them with the microspheres before injecting the paste into the vulnerable bones.

Dr Ahmed said: "If it works, this kind of treatment could be done in a day.

Until now the team have been funded by the Engineering and Physical Sciences Research Council but they are now looking for a commercial partner.

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Bone paste could provide treatment for ostoeporosis ...

Stem Cell Children at BioKidz to benefit from child friendly recipes designed by TV Celebrity Health Food Chef, Sally …

By adminSeptember 18, 2014Stem Cell Medicine

(PRWEB UK) 18 September 2014

Sally Bee, whose children have their stem cells stored with specialist bank BioEden has just released videos and recipes for BioKidz, the children whose stem cells are stored with this specialist bank.

Sally appears regularly on British TV, and is a wonderful ambassador for all things health, given that her survival of 3 heart attacks in one week at a very young age, was put down to a healthy lifestyle.

Sally is a wonderful cook, who creates amazing food from simple fresh ingredients,and is supporting BioEden the tooth stem cell bank in their quest to bring stem cell medicine and science to children and to schools.

BioKidz was launched by BioEden in the UK just 2 days ago, and promotes healthy living for children who are members of BioKidz. The BioKidz site is a fun way for children to look inside a tooth stem cell laboratory, whilst not overlooking the all important basics of good food, an active lifestyle and having fun whilst growing up!

Sally will be promoting BioKidz in a special schools education programme which is to start in her home town later this month.

BioEden's CEO Tony Veverka said, 'I am delighted that Sally has chosen to support BioEden and BioKidz and I look forward to involving more schools not just in the UK, but around the world of the importance of stem cell banking.

Visit BioKidz by visiting the main BioEden website

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Stem Cell Children at BioKidz to benefit from child friendly recipes designed by TV Celebrity Health Food Chef, Sally ...

Global Stem Cells Group Signs Consortia Innovas, SA to Exclusive Representative Contract for Chile Territory

By adminSeptember 15, 2014Stem Cell Medicine

MIAMI (PRWEB) September 15, 2014

Global Stem Cells Group, Inc. has signed an exclusive representative contract with Consortia Innovas, SA, a Santiago, Chile-based health management, development and biotech company. Founded by entrepreneur Enrique Testart, M.D., Consortia Innovas focuses on helping patients gain access to the latest medical treatments regenerative medicine has to offer.

According to Global Stem Cells Group Founder Benito Novas, Testart searches the globe for innovative stem cell companies that fit in with the Chilean markets, and Global Stem Cells Group turned out to be a perfect fit. Innovas will be in charge of all Global Stem Cells Group divisions and programs in Chile, including patient recruiting through Regenestem, physician training and certification trough Stem Cell Training, and stem cell equipment and disposables sales through Adimarket.

Regenestem, Stem Cell Training and Adimarket are all subsidiaries of the Global Stem Cells Group brand.

Our main objective is to organize Chiles first symposium on Stem Cells and Regenerative Medicine in Santiago in early 2015, Novas says. Our new alliance with Consortia Innovas will allow us to establish our brand as the leader in regenerative medicine therapies in Chile.

The first annual Global Stem Cells Symposium is scheduled to take place in Buenos Aires Oct 2, 2014, to be preceded by an intensive two-day hands-on training course in stem cell harvesting, isolation and applications Sept. 27 and 28 at Santiagos Innovas facilities.

The key to Global Stem Cells Groups strategy to expand into foreign markets by recruiting local representatives and distributors like Consortia Innovas to help manage the companys growth in a specific geographic area. Global Stem Cells group requires any company under consideration for the expansion program to have more than five years experience in the health care industry with at least some experience in the field of regenerative medicine .

In addition, geographic alliances require a commitment to a number of stem cell training courses during a one-year period, certification of physicians, and willingness to organize a large medical meeting or symposium in their territory.

To learn more about the Global Stem Cells Group alliance with Consortia Innovas, SA, visit http://www.stemcellsgroup.com, email bnovas(at)stemcellsgroup(dot)com, or call 305.224.1858.

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Global Stem Cells Group Signs Consortia Innovas, SA to Exclusive Representative Contract for Chile Territory

Significant milestone in stem cell research at The Wellcome Trust – Medical Research Council institute

By adminSeptember 13, 2014Stem Cell Medicine

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Scientists are celebrating a breakthrough in stem cell research.

A type of human stem cell has been replicated in a lab for the first time in history.

The cells, previously impossible to duplicate, have been recreated to the equivalent of those between seven and nine days old the same as found in an embryo before it implants in the womb.

The creation of the human pluripotent cells opens a door for specialised cells to be created in the future for use in regenerative medicine.

The Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute led the research, which was carried out by both British and Japanese academics.

Professor Austin Smith, director, said: "Our findings suggest that it is possible to rewind the clock to achieve true ground state pluripotency in human cells.

"These cells may represent the real starting point for formation of tissues in the human embryo. We hope that in time they will allow us to unlock the fundamental biology of early development, which is impossible to study directly in people."

The "reset" cells could be used as "raw material" for therapies, as well as diagnostic tools and drug screenings.

Scientists also hope that after further studying, the cells will help them learn more about how an embryo develops correctly, and how miscarriages and developmental disorders are caused.

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Significant milestone in stem cell research at The Wellcome Trust - Medical Research Council institute

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