Stem Cells | ICMS — Advancing Stem Cell Treatments, Stem …

T he International Cellular Medicine Society (ICMS) is an international non-profit dedicated to patient safety through strict evaluation of protocols and rigorous oversight of clinics and facilities engaged in the translation of point-of-care cell-based treatments.As a Professional Medical Association, the ICMS represents Physiciansand Researchersfrom over 35 countries who share a mission to provide Scientifically Credible and Medically Appropriate Treatments to Informed Patients.Join the ICMS.

The ICMS Works Tirelessly for the Clincial Translation of Field of Cell-Based Point-of-Care Treatments through:

Comprehensive Medical Standards and Best Practice Guidelines for Cell Based Medicine,

Strict Evaluation and Rigerous Oversight of Stem Cell Clinics and Facilities through aGlobal Accreditation Process,

Physician Education through daily updates on the latest Research on Stem Cells, the monthly Currents In Stem Cell Medicine and the annual International Congress for Regenerative and Stem Cell Medicine.

Join the ICMSto receive the latest news and research from cell-based medicne, including the bi-monthly publication, Currents in Stem Cell Medicine.

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Scientist admits mistakes in stem cell 'discovery'

The Japanese scientists who made an apparently groundbreaking discovery in the field of stem cell research earlier this year has called for his research to be withdrawn amid speculations about the validity of the findings.

In January the researcher claimed to have discovered that stem cells could be made quickly and cheaply by simply dipping cells in acid to convert them into the biological building blocks. But the images used in the report were brought into question and other teams of researchers have failed to emulate the results.

The study's author Professor Teruhiko Wakayama said, "It is no longer clear what is right."

Stem cells are set to play a vital role in the future of regenerative medicine as they can transform into any other type of tissue. Teams of scientists are exploring their application in restoring sight to the blind and mending damage caused by heart attacks.

The original study was published in the journal Nature and hit headlines after being branded a

"major scientific discovery" as it suggested stem cells no longer had to be taken from embryos or made with complex and costly genetic manipulation.

While the pioneering findings, which suggested simply shocking cells with acid could cause them to revert to stem cells, has not been discredited it has been called into question.

Wakayama reportedly told Japanese TV, "When conducting the experiment, I believed it was absolutely right. But now that many mistakes have emerged, I think it is best to withdraw the research paper at once and, using correct data and correct pictures, to prove once again the paper is right.

"If it turns out to be wrong, we would need to make it clear why a thing like this happened."

WENN.com

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Scientist admits mistakes in stem cell 'discovery'

Top Las Vegas Pain Management Clinic, Nevada Pain, Now Offering Stem Cell Therapy to Help Avoid Joint Replacement

Las Vegas, Nevada (PRWEB) March 12, 2014

The top Las Vegas pain management centers, Nevada Pain, are now offering regenerative medicine treatments including stem cell therapy and platelet rich plasma therapy. These treatments offer significant potential for repairing injured soft tissues and arthritis. Call (702) 323-0553 for more information and scheduling.

Traditional pain management treatments typically work exceptionally well, however, they act as a proverbial "band aid" to mask pain. Regenerative medicine, on the other hand, may regenerate damaged tissue while providing exceptional pain relief.

Treatments are offered by the Board Certified, Award Winning Las Vegas pain management doctors at Nevada Pain. Platelet rich plasma therapy is one of the treatments offered, which involves a simple blood draw from the patient. The blood is spun rapidly to create a mixture of concentrated platelets and growth factors, which is then injected into the problem area.

Stem cell injections involve treatments with either bone marrow, fat derived or amniotic derived material. The injections are offered as an outpatient and involve very little risk. Each treatment provides a significant concentration of growth factors and stem cells to help with repair.

In addition to regenerative medicine options, Nevada Pain offers over 50 pain management treatments including radiofrequency ablation, spinal cord stimulator implants, several types of epidural injections, and all kinds of nerve blocks. Success rates at the clinic typically exceed 90%.

For more information and scheduling, call (702) 323-0553.

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Top Las Vegas Pain Management Clinic, Nevada Pain, Now Offering Stem Cell Therapy to Help Avoid Joint Replacement

Okyanos CEO Matt Feshbach Announces Appointment of Institutes Marketing Executive Erika Rosenthal to International …

Freeport, The Bahamas (PRWEB) March 10, 2014

Matt Feshbach, CEO of Okyanos Heart Institute whose mission it is to bring a new standard of care and better quality of life to patients with coronary artery disease using cardiac stem cell therapy has announced the appointment of Okyanos senior vice president of marketing, Erika Rosenthal, to the International Stem Cell Society (STEMSO) Advisory Board. She will advise the trade organization in a communications capacity to benefit the membership and the mission.

STEMSO is a member-based, international, non-profit 501(c) 6 trade association which promotes the interests of organizational members of the global, adult stem cell healthcare community. STEMSO provides information, education, resources, advocacy and public awareness for the advancement of adult stem cell research and therapy. The organization recently hosted a global regenerative medicine conference in Freeport, The Bahamas, entitled, Bridging the Gap: Research to Point of Care which brought together experts in adult stem cell therapy and regulations to discuss commercialization of therapies for chronic disease in a safe, ethical, and compliant manner.

STEMSO is an important organization to the field of stem cell therapy and research, said Feshbach. Communications and healthcare are both fields in which Erika excels, and so I am pleased to see her lend her expertise for an important cause. I look forward to the Okyanos Heart Institute executive team continuing with such efforts for the greater good of medicine.

Rosenthal was a 2008 recipient of the National Association of Women Business Owners Business Woman of the Year award, and was recognized in Business Leader Magazine as a Woman Extraordinaire, for her business accomplishments and contributions to the non-profit community. She is a former faculty member of the University of California where she taught Marketing and Hospitality Management.

It is indeed an honor to work with STEMSO to advance their cause to help advance adult stem cell research and therapy worldwide, and to bring together leading researchers, physicians, regulators and scientists to set standards for ethical and responsible delivery of therapies as they become available to the public worldwide, said Rosenthal. It is an exciting time in medicine, and STEMSO is greatly needed to bring collaboration and guidance between this impressive member group of thought leaders.

STEMSO is pleased to have Erika Rosenthal participate on STEMSOs Advisory Board, said Douglas Hammond, president of STEMSO. Non-profit trade associations are only as strong as their member participation and leadership allows. If other members or prospective organizational members were to support STEMSO as Okyanos Heart Institute and Erika Rosenthal, there would be no limit to STEMSOs impact in the Regenerative Medicine Industry.

About Okyanos Heart Institute: (Oh key AH nos) Based in Freeport, The Bahamas, Okyanos Heart Institutes mission is to bring a new standard of care and a better quality of life to patients with coronary artery disease using cardiac stem cell therapy. Okyanos adheres to U.S. surgical center standards and is led by Chief Medical Officer Howard T. Walpole Jr., M.D., M.B.A., F.A.C.C., F.S.C.A.I. Okyanos Treatment utilizes a unique blend of stem and regenerative cells derived from ones own adipose (fat) tissue. The cells, when placed into the heart via a minimally-invasive procedure, can stimulate the growth of new blood vessels, a process known as angiogenesis. Angiogenesis facilitates blood flow in the heart, which supports intake and use of oxygen (as demonstrated in rigorous clinical trials such as the PRECISE trial). The literary name Okyanos, the Greek god of rivers, symbolizes restoration of blood flow.

END

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Okyanos CEO Matt Feshbach Announces Appointment of Institutes Marketing Executive Erika Rosenthal to International ...

Loss of antioxidant protein Nrf2 represses regeneration of muscle lost to aging

PUBLIC RELEASE DATE:

8-Mar-2014

Contact: Phil Sahm phil.sahm@hsc.utah.edu 801-581-2517 University of Utah Health Sciences

(SALT LAKE CITY)Good news for lifelong exercisers: Along with its salutary effects on the heart, weight, and other facets of health, physical activity also helps to regenerate muscle mass, which tends to diminish as people age.

In a study published in the journal Free Radical Biology and Medicine, researchers from the University of Utah and other institutions found that aged mice lacking Nrf2 that underwent two weeks of endurance exercise stress on treadmills showed poor stem cell regeneration, which is likely to hinder the recovery of lost muscle mass. Nrf2 is protein that regulates the production of antioxidants in the body.

"Physical activity is the key to everything," says Raj Soorappan, Ph.D., assistant research professor of medicine at the University of Utah and senior author on the study. "After this study, we believe that moderate exercise could be one of the key ways to induce stem cells to regenerate especially during senescence."

Sarcopenia age-related loss of skeletal muscle mass occurs naturally and begins in most people around age 30. Fortunately, to help stem this tide, the body produces antioxidants, which are molecules that help maintain muscle mass through the regeneration of stem cells that become muscle cells.

For reasons not yet entirely known, as people age, their bodies produce fewer antioxidants. This can result in oxidative stress, a condition in which the level of molecules called free radicals rogue electrons that travel through the body triggering chemical reactions that damage proteins and cells exceeds that of antioxidants. When this happens, stem cell regeneration and, consequently, formation of muscle cells doesn't keep up with muscle mass loss.

Nrf2 is a protein and transcription factor that turns on and off the genes that produce antioxidants. To test the role of Nrf2 in regeneration of skeletal muscle during aging, Soorappan tested two groups of mice that were 23 months or older the murine equivalent of senior citizens. In one group of mice the gene that codes for Nrf2 had been knocked out while the other group of mice was able to produce the protein. Each group underwent endurance training to create a profound oxidative stress setting.

Typically, regeneration, maintenance and repair of adult skeletal muscle damage due to aging and/or chronic stress states require activation of satellite cells (stem cells). In the group that couldn't produce Nrf2, endurance exercise stress on the treadmills affected stem cell protein expression and limited skeletal muscle regenerative capacity.

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Loss of antioxidant protein Nrf2 represses regeneration of muscle lost to aging

Guidelines on use of stem cell therapy

Google stem cell therapy and a whole host of results show up. Stem cell therapy for hair loss, diabetes, cancer and practically everything else. It is touted as the medicine of hope, the panacea for all ills.

But to ensure that this potentially-powerful technology is not misused in the country, the Indian Council of Medical Research has come up with a set of guidelines to regulate their use.

Under the new guidelines, any use of stem cells in patients will be considered research, not therapy.

This means stem cells can now only be used on patients within the purview of an approved, and monitored clinical trial anything outside of this would be considered malpractice. Ananthram Shetty, professor of minimally-invasive surgery at Canterbury Christ Church University, UK, said the guidelines are much-needed, welcome move in the right direction.

Prof. Shetty, who has been working with stem-cell technology for 27 years, and is often in India to demonstrate their use in research surgeries, said this would prevent anybody and everybody from claiming unproven benefits. Lots of people dont really understand what stem cells are. And those who have a terminal illness are willing to try anything. There are some people who use this to raise false hopes. And this is what the guidelines seek to stop, he said.

J.S. Rajkumar, chairman, Lifeline Hospital, however, said the guidelines could have been clearer about the use of adult stem cells over embryonic stem cells, he said. Now, the procedures involved and the time it would take could dissuade many, he said, while there is a real need for funds to be pumped in for research into this technology.

Another International Ear Care Day passed by on March 3.

It spelled out a clear message ear care can avoid hearing loss.

But the question is how many people know how to take care of their ears. What is interesting is the ear is a self-cleaning organ and does not require any kind of cleaning. But many clean their ears using safety pins, hair pins and even matchsticks.

While doctors advise against the use of such objects, they discourage the use of cotton buds too. Some heat coconut oil and pour into the ears. This could cause fungal infections. The ear drum is very thin and can be damaged, leading to loss of hearing, said M. Ramaniraj, professor of ENT, Government Stanley Medical College Hospital.

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Guidelines on use of stem cell therapy

Human Embryonic Stem Cells Restore Gerbil Hearing

A new study offers proof that stem cells can reconnect the inner ear to the brain

Marcelo Rivolta, University of Sheffield

By Virginia Gewin of Nature magazine

More than 275 million people have moderate-to-profound hearing loss, and many of those cases are caused by a breach in the connection between the inner ear and the brain.

Researchers have now shown how to repair a key component of that connection the auditory nerve by using human embryonic stem cells to restore hearing in gerbils. "We have the proof of concept that we can use human embryonic stem cells to repair the damaged ear," says lead author Marcelo Rivolta, a stem-cell biologist at the University of Sheffield, UK, whose research appears in Nature today. "More work needs to be done, but now we know it's possible."

Stem cells have been differentiated into auditory nerve cells before, but this is the first time that transplanted cells have successfully restored hearing in animals. Some in the field say that it is a pivotal step that will undoubtedly spur more research. Research has been stymied by reviewers wanting evidence that stem cells can connect the inner ear to the central nervous system, says Richard Altschuler, a developmental biologist at the Kresge Hearing Research Institute at the University of Michigan in Ann Arbor.

Rivolta has spent the past decade developing ways to differentiate human embryonic stem cells into the two cell types that are essential for hearing: auditory neurons, and the inner-ear hair cells that translate sound into electrical signals.

He treated human embryonic stem cells with two types of fibroblast growth factor (FGF) FGF3 and FGF10 to produce two, visually distinct, groups of primordial sensory cell. Those that had characteristics similar to hair cells were dubbed otic epithelial progenitors (OEPs), and those that looked more like neurons were dubbed otic neural progenitors (ONPs).

His team then transplanted ONPs into the ears of gerbils that had been treated with ouabain, a chemical that damages auditory nerves, but not hair cells. Ten weeks after the procedure, some ofthe transplanted cells had grown projections that formed connections to the brain stem. Subsequent testing showed that many of the animals could hear much fainter sounds after transplantation, with an overall improvement in hearing of 46%.

Hear this Rivoltas findings along with a study published in July showing that gene therapy can restore hearing in deaf-born mice reinforce a spate of studies demonstrating that stem cells and gene therapy can restore sensory functions, including smell (see 'Gene therapy restores sense of smell to mice') and vision (see 'Regenerative medicine repairs mice from top to toe').

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Human Embryonic Stem Cells Restore Gerbil Hearing

Patient-Specific Human Embryonic Stem Cells Created by Cloning

The breakthrough might set up another showdown about cloning for therapeutic purposes

OHSU Photos

From Nature magazine

It was hailed some 15 years ago as the great hope for a biomedical revolution: the use of cloning techniques to create perfectly matched tissues that would someday cure ailments ranging from diabetes to Parkinsons disease. Since then, the approach has been enveloped in ethical debate, tainted by fraud and, in recent years, overshadowed by a competing technology. Most groups gave up long ago on the finicky core method production of patient-specific embryonic stem cells (ESCs) from cloning. A quieter debate followed: do we still need therapeutic cloning?

A paper published this week by Shoukhrat Mitalipov, a reproductive biology specialist at the Oregon Health and Science University in Beaverton, and his colleagues is sure to rekindle that debate. Mitalipov and his team have finally created patient-specific ESCs through cloning, and they are keen to prove that the technology is worth pursuing.

Therapeutic cloning, or somatic-cell nuclear transfer (SCNT), begins with the same process used to create Dolly, the famous cloned sheep, in 1996. A donor cell from a body tissue such as skin is fused with an unfertilized egg from which the nucleus has been removed. The egg reprograms the DNA in the donor cell to an embryonic state and divides until it has reached the early, blastocyst stage. The cells are then harvested and cultured to create a stable cell line that is genetically matched to the donor and that can become almost any cell type in the human body.

Many scientists have tried to create human SCNT cell lines; none had succeeded until now. Most infamously, Woo Suk Hwang of Seoul National University in South Korea used hundreds of human eggs to report two successes, in 2004 and 2005. Both turned out to be fabricated. Other researchers made some headway. Mitalipov created SCNT lines in monkeys in 2007. And Dieter Egli, a regenerative medicine specialist at the New York Stem Cell Foundation, successfully produced human SCNT lines, but only when the eggs nucleus was left in the cell. As a result, the cells had abnormal numbers of chromosomes, limiting their use.

Monkeying around Mitalipov and his group began work on their new study last September, using eggs from young donors recruited through a university advertising campaign. In December, after some false starts, cells from four cloned embryos that Mitalipov had engineered began to grow. It looks like colonies, it looks like colonies, he kept thinking. Masahito Tachibana, a fertility specialist from Sendai, Japan, who is finishing a 5-year stint in Mitalipovs laboratory, nervously sectioned the 1-millimetre-wide clumps of cells and transferred them to new culture plates, where they continued to grow evidence of success. Mitalipov cancelled his holiday plans. I was happy to spend Christmas culturing cells, he says. My family understood.

The success came through minor technical tweaks. The researchers used inactivated Sendai virus (known to induce fusion of cells) to unite the egg and body cells, and an electric jolt to activate embryo development. When their first attempts produced six blastocysts but no stable cell lines, they added caffeine, which protects the egg from premature activation.

None of these techniques is new, but the researchers tested them in various combinations in more than 1,000 monkey eggs before moving on to human cells. They made the right improvements to the protocol, says Egli. Its big news. Its convincing. I believe it.

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He mapped the human genome, now he wants to 'cure' aging

Craig Venter, the U.S. scientist who raced the U.S. government to map the human genome over a decade ago and created synthetic life in 2010, is now on a quest to treat age-related disease.

Venter has teamed up with stem cell pioneer Dr Robert Hariri and X Prize Foundation founder Dr Peter Diamandis to form Human Longevity Inc., a company that will use both genomics and stem cell therapies to find treatments that allow aging adults to stay healthy and functional for as long as possible.

Were hoping to make numerous new discoveries in preventive medicine. We think this will have a huge impact on changing the cost of medicine, Venter said on a conference call announcing his latest venture.

The San Diego-based startup company has $70-million in private backing and has already purchased two ultrafast HiSeq X Ten gene sequencing systems from Illumina Inc, a leading manufacturer of DNA sequencing machines, with the option to buy three more.

The company will use that technology to map 40,000 human genomes in a push to build the worlds largest database of human genetic variation. The database will include sequences from the very young through the very old, both diseased and healthy.

This will be one of the largest data studies in the history of science and medicine, Venter told the conference call.

In addition to gathering whole genome data, the company will collect genetic data on the trillions of microbes including bacteria, viruses and fungi living in and on humans.

By better understanding the microbiomes in the gut, in the mouth, on the skin and other sites on the body, the company said it hopes to develop better probiotics as well as better diagnostics and drugs to improve health and wellness.

Along with the microbiome data, Human Longevity Inc. or HLI will collect data on the metabolome the various metabolites, biochemicals and fats in the body in order to get a better picture of the circulating chemicals that contribute to health and affect how drugs work.

The companys initial treatment targets will be some of the toughest age-related diseases: cancer, diabetes and obesity, heart and liver diseases, and dementia.

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He mapped the human genome, now he wants to 'cure' aging

Stem.MD | National Regenerative Medical Practice

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Thank you for giving my life and health back. The PRP treatment worked wonders and helped alleviate the pain. I highly recommend the anti-inflammatory diet, Dr. Purita suggested. My body noticed the difference and I lost 35 pounds. I can finally be active again!

Jennica Califf Coconut Creek, Florida

I thought there was no hope for my chronic back pain. I am so thankful I found out about Dr. Purita and stem cells. I have had back pain for over 5 years, debilitating me to do everyday things. Today my pain has gone down 50%. I tell all my friends and family and wish everyone knew about this wonderful treatment. Thank you so much Dr. Purita

It has been 3 months since my mothers procedure to her knees. Now, my mom climbs into the van without any help, before we had to pull her up and assist her. She does not take painkillers anymore, even her recurring bladder infection and Diabetes is well controlled. All my friends and colleagues are super amazed every time I show them a video of my mom dancing. Thank you so much what you have done for my mom it is truly wonderful and I am forever indebted to you.

Malou Aragon-De Veyra Philippines

I came to Dr. Purita on the advice of a friend when I expressed trepidations about cortisone shots or the possibility no matter how remote of a joint replacement. I was a wrestler in high school and college, and this had done no good for my kneed as I aged. I had no expectations, only hope that somehow my knees could be made less fragile by the stem cell therapy my friend described. I had gotten to the point where any down stairs journey or stepping down off a van or public bus was excruciating, to the point that I usually made an exclamation that wasn't fit for public utterance every time I stepped off a bus or a van. My expectations were neutral at best. I had no idea as to how this stem cell therapy would impact my general health whatsoever. I can say without hesitation that the results have been beyond what I could have hoped. My knees are now cooperative to the point that sometimes I take the stairs down just because I can. I have resumed walking the stairs up and down at work, and I can say that I really don't think about anything I want to do where my kneed are involved. I am not quite where I was when I was 20, but 35 is a real thought, my flexibility and agility are restored to a level I could not have imagined. As an additional part of the procedure Dr. Purita also injected stem cell into my left hand, which has been diagnosed with some arthritis. The results are less instantaneously spectacular, but the had continues to improve. I no longer sit in my office while my hand burns with joint pain, my movement and most of my strength are improving daily, and I have a feeling that within a month or so I will have the same level of improvement I have experiences with my knees. Many thanks to the friend who recommended the trip to Dr. Purita's office, and to Dr. Purita and his staff who have put thoughts of joint replacement and the mad merry-go-round of cortisone shots far in the past for me.

Mark Burns Hypoluxo, Florida

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