Category Archives: Stem Cell Medicine


Asymmetrex’s Kinetic Stem Cell (KSC) Counting Technology Is Featured in the Parent’s Guide to Cord Blood Foundation June Newsletter – 69News WFMZ-TV

The Parent's Guide to Cord Blood Foundation's monthly newsletter reports on research and development of medical treatments using blood and tissues from human umbilical cords in language that is accessible to parents of children receiving or considering such treatments. The June 14 issue of the newsletter features a graphical presentation of stem cell biotechnology company Asymmetrex's KSC technology, which can provide, for the first time, the dosage of the therapeutic stem cells in umbilical cord blood and tissues.

BOSTON, June 15, 2022 /PRNewswire-PRWeb/ -- The Parent's Guide to Cord Blood Foundation is well known for its excellence in advocacy and education to support parents negotiating medical treatments for their children that involve umbilical cord blood and tissues. The Parent's Guide monthly newsletter has a goal of presenting new advances in umbilical cord medical research and treatments in terms that are accessible by parents and others who are not experts. The June 2022 issue, published June 14, provides a graphical presentation of stem cell biotechnology company Asymmetrex's technology that provides the dose of therapeutic umbilical cord stem cells for the first time.

Determining the dosage of therapeutic tissue stem cells is a long-standing unmet need for all tissue stem cell therapies. More commonly mis-called "adult stem cells," tissue stem cells include stem cells found in adults, children, and birth tissues like the placenta and the umbilical cord. Donor umbilical cords are currently a major focus for sourcing therapeutic tissue stem cells, which are found in both their blood (hematopoietic stem cells) and their walls (mesenchymal stem cells). Whereas the medical potential of cord mesenchymal stem cells is still under investigation, the medical efficacy of cord blood hematopoietic stem cells is well established for use in the treatment of childhood leukemias.

Cord blood treatments for children have a continuing need for a method to determine the dose of the therapeutic stem cells. The Parent's Guide newsletter feature describes the two industry standards for certifying cord blood units, flow cytometry and the colony-forming unit (CFU) test. Although they are currently industry certification requirements, neither of these methods gives the stem cell dose or tells which cord blood units will be effective. By some reports, this deficiency leaves nearly 20% of treated children at risk for death.

This June's article is the Parent's Guide newsletter's second feature on Asymmetrex's tissue stem cell counting technology. The first feature appeared in the January 2019 issue of the newsletter. It related the historical context, envisioned applications, and potential impact of kinetic stem cell (KSC) counting, but did not delve into how the technology worked. The latest feature uses a graphical slide format to illustrate how Asymmetrex applies computational simulation to conventional cell count data to determine the number of tissue stem cells in a sample. Asymmetrex's President and CEO James L. Sherley, M.D., Ph.D. is confident that the newsletter's presentation "will help both non-experts and experts to understand how Asymmetrex counts therapeutic tissue stem cells."

In the intervening 3 years, the company's KSC counting technology has advanced greatly. Just in the previous week, at the Meeting in the Millyard Summit of the Advanced Regenerative Manufacturing Institute, the company announced rapid-counting algorithms that will make stem cell counting sufficiently efficient to be performed routinely for research and medicine. CEO Sherley says that he is looking forward to a future Parent's Guide newsletter reporting the use of KSC counting to identify cord blood units that work all of the time for children, instead of only about 80% of the time as now.

About Asymmetrex

Asymmetrex, LLC is a Massachusetts life sciences company with a focus on developing technologies to advance stem cell medicine. The company's U.S. and U.K. patent portfolio contains biotechnologies that solve the two main technical problems stem cell-specific quantification and stem cell expansion that have stood in the way of more-effective use of human adult tissue stem cells for regenerative medicine and drug development. Asymmetrex markets kinetic stem cell (KSC) counting, the first technology for determination of the dose and quality of tissue stem cell preparations for use in stem cell transplantation medicine and pre-clinical drug evaluations. Asymmetrex is a member company of the Advanced Regenerative Manufacturing Institute | BioFabUSA (ARMI) and the Massachusetts Biotechnology Council (MassBio).

Media Contact

James L. Sherley, M.D., Ph.D., Asymmetrex LLC, 617-990-6819, jsherley@asymmetrex.com

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Asymmetrex's Kinetic Stem Cell (KSC) Counting Technology Is Featured in the Parent's Guide to Cord Blood Foundation June Newsletter - 69News WFMZ-TV

VITASPRING BIOMEDICAL CO. LTD. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS. (form 10-Q) – Marketscreener.com

Management's Discussion and Analysis of Financial Condition and Results of Operations

Caution Regarding Forward-Looking Information

This Quarterly Report on Form 10-Q, including, without limitation, statements containing the words "believes", "anticipates", "expects" and words of similar import, constitute forward-looking statements. Such forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the actual results, performance or achievements of the Company, or industry results, to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements.

Such factors include, among others, the following: international, national and local general economic and market conditions: demographic changes; the ability of the Company to sustain, manage or forecast its growth; the ability of the Company to successfully make and integrate acquisitions; existing government regulations and changes in, or the failure to comply with, government regulations; adverse publicity; competition; fluctuations and difficulty in forecasting operating results; changes in business strategy or development plans; business disruptions; the ability to attract and retain qualified personnel; and other factors referenced in this and previous filings.

Given these uncertainties, readers of this Form 10-Q and investors are cautioned not to place undue reliance on such forward-looking statements. The Company disclaims any obligation to update any such factors or to publicly announce the result of any revisions to any of the forward-looking statements contained herein to reflect future events or developments.

VitaSpring Biomedical Co. Ltd., formerly Shemn Corp., was incorporated in Nevada on September 6, 2016. We are a start-up business company. We have been engaged in the business of developing and marketing products that promote wellness and a healthy lifestyle since 2019. A change of 100% of Company's ownership occurred effectively on January 21, 2020. As a result, we changed Company name from Shemn Corp. to VitaSpring Biomedical Co. Ltd. on February 17, 2020.

VitaSpring Biomedical Co., Ltd aims to build a cell medical industry, invest in research and development of stem cell applications in regenerative medicine, establish advanced medical research centers and high standard cell production centers, and provide "GTP" standard stem cell preparations for the development of cellular drugs.

For future business development and medical applications, VitaSpring cooperates with affiliated companies to support the mass production and commercialization of X.msc-related medical projects. Some X.msc-based projects are researches and trials of Investment New Drugs and part of them are related to X.exosome, the critical material in the related skincare products. VitaSpring management also expect X.msc-related medical projects to implement in hospitals from a small scale in the future five years.

On March 30, 2020, VitaSpring filed a Certificate of Amendment to its Articles of Incorporation (the "Articles of Amendment") with the Secretary of State of the State of Nevada effecting a name change of the Company to VitaSpring Biomedical Co. Ltd. (the "Corporate Action"). The Corporate Action and the Amended Articles became effective on April 21, 2020, following compliance with notification requirements of the Financial Industry Regulatory Authority.

Under new management, VitaSpring has completed the transition from patent technology into the know-how in the mass-production process of the purifying and culturing technology in the allogeneic mesenchymal stem cell production from the maternal-part placenta. The subject know-how can effectively and steadily culture more than 20 generations of sub-culture cells, which maintain the same level of activity index and contain the magnification of one thousand exosomes than other MSCs in terms of per ml. Accordingly, VitaSpring is able to build stem cell bank regulated by US FDA to provide the ready-to-use allogeneic mesenchymal stem cell for the emergent allogeneic stem cell transplantation at the cost the patient can afford.

VitaSpring's research team has been awarded the 16th, 17 th, 18 th Taiwan National Innovation Award certificates in 2019, 2020, and 2021 and joined the regenerative medicine flagships of the Ministry of Science and Technology from 2007 to 2020, including research projects for the mechanism of human placenta mesenchymal stem cells in different diseases. It highlights the technological foundation for the future clinical application of X.msc.

Through the development of cell medicine, we became a leading international business group in the fields of regenerative medicine applied to the innovative fields of medicine, preventive health care, beauty, and anti-aging. We do not sell products in a form for use by consumers although we may, in the future, develop products for use by consumers.

We have many unique advantages elevating us to be the best in the industry:

1. Discovery and successful isolation of special mesenchymal stem cells (X.msc)

2. Unlike typical MSCs, X.msc do not promote cancer and tumor growth, and is safe to use for the entire body

3. Homogeneous purification technology

4. Viability of X.msc is 1000 time that of the competitor

5. Able to proliferate and maintain stemness of stem cells to 25+ generations

6. Exclusive composition formula of culture medium

7. The exclusive formula of exosomes have a variety of applications

8. Extensive uses of X.msc

9. Immunomodulation and anti-inflammation effect

We file with the SEC our annual reports on Form 10-K, quarterly reports on Form 10-Q, current reports on Form 8-K and amendments to reports to be filed pursuant to Sections 13(a) and 15(d) of the Securities Exchange Act of 1934, as amended. The public may read and copy any materials we file with the SEC at the SEC's Public Reference Room at 100 F Street, NE, Washington, D.C. 20549, on official business days during the hours of 10 a.m. to 3 p.m. The public may obtain information on the operation of the Public Reference Room by calling the SEC at 1-800-SEC-0330. The SEC maintains a website at http://www.sec.gov that contains reports, proxy and information statements, and other information regarding issuers that file electronically with the SEC.

Our corporate headquarters are located at 400 Spectrum Center Dr. #1620, Irvine, CA 92618. Our telephone number is (949) 202-9235. We maintain a website at http://www.vitaspringbio.com that links to our electronic SEC filings and contains information about our subsidiaries which is not a part of this report. All the above documents are available free of charge on our website as soon as reasonably practicable after filing such material electronically or otherwise furnishing it to the SEC

Results of Operations for the Three months Ended April 30, 2022 Compared to the Three months ended April 30, 2021

Revenue and cost of goods sold

For the Three months ended April 30, 2022 and April 30, 2021 the Company generated total revenue of $1,490,000 and $533,800 from selling products to the customer. The cost of goods sold for the quarter ended April 30, 2022 and April 30, 2021 was $922,000 and $294,000, which represent the cost of raw materials.

Total operating expenses for the quarter ended April 30, 2022 and April 30, 2021 were $224,873 and $60,390. The increase was primarily related to increased selling, general and administrative expenses.

The net income for the quarter ended April 30, 2022 and April 30, 2021 was $276,656 and $235,662, accordingly.

Liquidity and Capital Resources and Cash Requirements

At April 30, 2022, the Company had cash of $79,151. The Company had working capital of $1,823,019.

During the quarter ended April 30, 2022, the Company generated $(28,061) of cash in operating activities.

During the quarter ended April 30, 2022 the Company used no cash in investing activities or financing activities.

We cannot guarantee that we will manage to sell all the shares required. We will attempt to raise the necessary funds to proceed with all phases of our plan of operation. As of the date of this report, the current funds available to the Company will not be sufficient to continue maintaining a reporting status.

Our auditors have issued a "going concern" opinion, meaning that there is substantial doubt we can continue as an on-going business for the next twelve months unless we obtain additional capital. Our only sources for cash at this time are investments by others in this offering, selling our paper dung products and loans from our director. We must raise cash to implement our plan and stay in business.

Management believes that current trends toward lower capital investment in start-up companies pose the most significant challenge to the Company's success over the next year and in future years. Additionally, the Company will have to meet all the financial disclosure and reporting requirements associated with being a publicly reporting company. The Company's management will have to spend additional time on policies and procedures to make sure it is compliant with various regulatory requirements, especially that of Section 404 of the Sarbanes-Oxley Act of 2002. This additional corporate governance time required of management could limit the amount of time management has to implement is business plan and impede the speed of its operations.

Limited operating history; need for additional capital

There is no historical financial information about us upon which to base an evaluation of our performance. We are in a start-up stage of operations and have generated limited revenues since inception. We cannot guarantee that we will be successful in our business operations. Our business is subject to risks inherent in the establishment of a new business enterprise, including limited capital resources and possible cost overruns due to price and cost increases in services and products.

Off-Balance Sheet Arrangements

We do not maintain any off-balance sheet arrangements, transactions, obligations or other relationships with unconsolidated entities that would be expected to have a material current or future effect upon our financial condition or results of operations.

The Company has a retained earnings of $1,093,380 and a negative cash flow from operations amounting to $(28,061) for the three months ended April 30, 2022. The Company had $1,490,000 in revenues for the three months ended April 30, 2022. The Company currently earned profit for the period and is in the process of completing its efforts to establish a stabilized source of revenue sufficient to cover operating costs over an extended period. Therefore, there is still a substantial doubt about the Company's ability to continue as a going concern. Management anticipates that the Company will be dependent, for the near future, on additional investment capital to fund operating expenses. The Company intends to position itself so that it will be able to raise additional funds through the capital markets. In light of management's efforts, there are no assurances that the Company will be successful in this or any of its endeavors or become financially viable and continue as a going concern.

Recent Accounting Pronouncements

In October 2016, the FASB issued ASU 2016-16, Income Taxes (Topic 740): Intra-Entity Transfer of Assets Other than Inventory, which requires the recognition of the income tax consequences of an intra-entity transfer of an asset, other than inventory, when the transfer occurs. ASU 2016-16 is effective for interim and annual periods beginning after December 15, 2018, with early adoption permitted. .

In February 2016, the FASB issued ASU 2016-02, Leases, which will amend current lease accounting to require lessees to recognize (i) a lease liability, which is a lessee's obligation to make lease payments arising from a lease, measured on a discounted basis, and (ii) a right-of-use asset, which is an asset that represents the lessee's right to use, or control the use of, a specified asset for the lease term. ASU 2016-02 does not significantly change lease accounting requirements applicable to lessors; however, certain changes were made to align, where necessary, lessor accounting with the lessee accounting model. This standard will be effective for fiscal years beginning after December 15, 2018, including interim periods within those fiscal years.

Management has considered all recent accounting pronouncements issued since and their potential effect on our financial statements. The Company's management believes that these recent pronouncements will not have a material effect on the Company's consolidated financial statements.

Other recent accounting pronouncements issued by the FASB, including its Emerging Issues Task Force, the American Institute of Certified Public Accountants, and the Securities and Exchange Commission did not or are not believed by management to have a material impact on the Company's present or future financial statements.

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VITASPRING BIOMEDICAL CO. LTD. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS. (form 10-Q) - Marketscreener.com

Orthopedic Regenerative Medicine Market To Witness the Highest Growth Globally in Coming Years 2022-2028: Ortho Regenerative Technologies Inc,…

TheGlobal Orthopedic Regenerative MedicineMarket 2022 by Manufacturers, Regions, Type and Application, Forecast to 2028 is a valuable source of insightful data for business strategists. It provides the industry overview with growth analysis and historical & futuristic cost, revenue, demand and supply data (as applicable). The research analysts deliver an elaborate description of the value chain, future roadmaps and its distributor analysis. This Market study offers comprehensive data that enhances the understanding, scope, and application of this report. Our reports are single-point solutions for businesses to grow, evolve, and mature. Our real-time data collection methods along with ability to track more than one million high growth niche Orthopedic Regenerative Medicine are aligned with your aims.

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Top LeadingCompanies/Players: Ortho Regenerative Technologies Inc, Personalized stem cells Inc., Anika Therapeutics Inc., Arthrex Inc., Baxter International Inc., Conmed Corporation, Aziyo Biologics, Curasan Inc., Swiss biomed Orthopedics AG, Octane Medical Inc., Stryker Corporation, Carmell Therapeutics Corporation, Zimmer Holdings, Smith & Nephew plc., NuVasive Inc., and Other.

This report segments the Global Orthopedic Regenerative Medicine Market on the basis of Types are:

Stem Cell Therapy (Allogeneic Bones, Autogeneic Bones, and Bone Grafting)

Plasma Based Therapy

Tissue Engineering (Allograft)

On the basis of Application, the Global Orthopedic Regenerative Medicine Market is segmented into

Osteoarticular Diseases

Rheumatoid Arthritis

Ligament Injuries

Bursitis

Osteoporosis

Region Included are:North America, Europe, Asia Pacific, Oceania, South America, Middle East & Africa

Country Level Break-Up:United States, Canada, Mexico, Brazil, Argentina, Colombia, Chile, South Africa, Nigeria, Tunisia, Morocco, Germany, United Kingdom (UK), the Netherlands, Spain, Italy, Belgium, Austria, Turkey, Russia, France, Poland, Israel, United Arab Emirates, Qatar, Saudi Arabia, China, Japan, Taiwan, South Korea, Singapore, India, Australia and New Zealand etc.

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The content of the study subjects, includes a total of 15 chapters:

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Chapter 2, to profile the top manufacturers of Orthopedic Regenerative Medicine, with price, sales, revenue and global market share of Orthopedic Regenerative Medicine from 2019 to 2022.

Chapter 3, the Orthopedic Regenerative MedicineOrthopedic Regenerative Medicine competitive situation, sales, revenue and global market share of top manufacturers are analyzed emphatically by landscape contrast.

Chapter 4, the Orthopedic Regenerative Medicine breakdown data are shown at the regional level, to show the sales, revenue and growth by regions, from 2017 to 2028.

Chapter 5 and 6, to segment the sales by Type and application, with sales market share and growth rate by type, application, from 2017 to 2028.

Chapter 7, 8, 9, 10 and 11, to break the sales data at the country level, with sales, revenue and market share for key countries in the world, from 2017 to 2022.and Orthopedic Regenerative Medicine market forecast, by regions, type and application, with sales and revenue, from 2022 to 2028.

Chapter 12, the key raw materials and key suppliers, and industry chain of Orthopedic Regenerative Medicine.

Chapter 13, 14, and 15, to describe Orthopedic Regenerative Medicine sales channel, distributors, customers, research findings and conclusion, appendix and data source.

Browse Full Report for TOC and Description:

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The report delivers an in-depth evaluation of the Orthopedic Regenerative Medicine market by highlighting data on different aspects which contains drivers, restraints, opportunities, and threats. This information can help stakeholders to make appropriate decisions before investing. Additional, it also allows you to do valuable competitor research to get inspiration for marketing the products. When it comes to satisfaction, it is necessary to get definitive idea about what is exactly going in the market. This report exactly provides overall market scenario.

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Orthopedic Regenerative Medicine Market To Witness the Highest Growth Globally in Coming Years 2022-2028: Ortho Regenerative Technologies Inc,...

Maike Sander named to lead the Max Delbrck Center – EurekAlert

image:Maike Sander has been selected to direct the Max Delbrck Center for Molecular Medicine (MDC). view more

Credit: Peter Himsel / MDC

On November 1, 2022, Prof. Maike Sander will take the reins as Scientific Director and Chair of the Board of the Max Delbrck Center for Molecular Medicine in the Helmholtz Association (MDC). The Supervisory Board of the MDC formally appointed her to the post on Thursday, June 16, 2022. The MDC, which is celebrating its 30th anniversary this year, is one of five Health Centers in the Helmholtz Association of German Research Centers. The internationally renowned researcher and experienced science manager Maike Sander will be succeeding Prof. Thomas Sommer, who has directed the MDC on an interim basis since 2019. That will make Sander the first woman to head one of the Helmholtz Health Centers.

The MDC has distinguished itself as an internationally renowned center for highly innovative biomedical research, says Maike Sander. Work at the MDC lays the foundation for better medicine of the future. The MDC provides on outstanding environment for research and attracts talent from around the globe. I had the opportunity to experience this first-hand as a visiting professor at the MDC. As Scientific Director, my goal will be to further strengthen the MDCs role as a leading biomedical research center and to deepen partnerships with other institutions in Berlin and beyond, so that our discoveries can be rapidly turned into medical innovations. Sander emphasizes that medical innovation needs strong basic science, clinical science and industry partners components that are all part of the vibrant Berlin biomedical ecosystem, she points out. The Berlin region is developing into a flourishing biotech pharma hub and I see the MDC as a principal driver of innovation in this landscape. I very much look forward to working with all stakeholders across Berlin.

Maike Sanders research focuses on identifying novel therapeutic approaches for diabetes. To this end, Sander studies the molecular mechanisms that underlie the formation and function of the different cell types in the pancreas, in particular the insulin-producing beta cells. Her goal is to identify strategies for replacing beta cells in diabetes using beta cells derived from human pluripotent stem cells.

Since 2012, Sander has served as the Director of the Pediatric Diabetes Research Center at the University of California, San Diego (UC San Diego), where she is also a Professor in the Departments of Pediatrics and Cellular & Molecular Medicine. In Berlin, Maike Sander will be appointed as Professor at the Charit Universittsmedizin.

Maike Sander is an outstanding scientist with a track record of innovation in biomedical research, says Bettina Stark-Watzinger, Germanys Federal Minister of Education and Research. I am delighted we have been able to bring her back to Germany after many years in the United States and to win her as the new Scientific Director of the Max Delbrck Center. It demonstrates the attractiveness of Berlin as a hub for biomedical research. As a scientist and administrator, Prof. Sander is the perfect match for the MDC with its mission to improve human health through transformative biomedical research. Also, having a female leader is an important signal. Prof. Sanders appointment represents a significant gain for German research.

Berlins Senator for Higher Education and Research, Health, Long-Term Care and Gender Equality, Ulrike Gote, says: In Prof. Maike Sander, the Max Delbrck Center has gained an internationally renowned scientist as its new Scientific Director. I warmly welcome her to the science and healthcare metropolis Berlin. Prof. Sanders expertise and experience provide the ideal background for future development of the MDC and for increasing the international visibility of the vibrant life sciences community at the MDC and in Berlin. As the senator in charge of higher education, research, and gender equality, I am delighted to see a woman at the helm of a Helmholtz Health Center.

I got to know Maike Sander as an expert in diabetes and stem cells when she was a visiting professor at the MDC, says OtmarD.Wiestler, President of the Helmholtz Association. With her high scientific standing and international experience, she is the ideal person to determine the future direction of the MDC as Scientific Director and Chair of the Board. With Prof. Sander we are gaining an excellent scientist whose expertise will be of tremendous benefit to the Helmholtz Association. A critical focus area is the development of precision medicine approaches. The MDC is at the forefront of advancing research in this important area. I look forward to working with Prof. Sander and to a vivid exchange of ideas.

Maike Sander, a native of Gttingen, is 54 years old. After graduating with a medical degree from the University of Heidelberg Medical School in 1994, she conducted research at the University of California, San Francisco. Before moving to UC San Diego in 2008, she held faculty positions at Hamburg Medical School and the University of California, Irvine. An expert on insulin-producing pancreatic beta cells, she has nearly 30 years of experience in medicine and diabetes research.

Sander is an elected member of the German National Academy of Sciences Leopoldina, the Association of American Physicians, and the American Society of Clinical Investigation. In addition, she is a member of two NIH consortia: The Human Islet Research Network and the NIH Impact of Genomic Variation on Function Consortium, which seeks to define basic mechanisms of gene regulation.

She is a recipient of the Grodsky Award of the Juvenile Diabetes Research Foundation, the 2022 Albert Renold Prize of the European Association for the Study of Diabetes, and the Alexander von Humboldt Foundation Research Award. Since 2019, Sander has been an Einstein Visiting Fellow at the Berlin Institute of Health at Charit (BIH).

30 Years MDC

Sander Laboratory and Publications at University of California, San Diego

German Federal Ministry of Education and Research (BMBF) Division for Press; Social Media; Internet Kapelle-Ufer 1 10117 Berlin +49-(0)30-1857-5050 presse@bmbf.bund.de

Jutta Kramm Head of the Staff Unit Communications Max Delbrck Center for Molecular Medicine in the Helmholtz Association (MDC) +49-(0)30-9406-2140 jutta.kramm@mdc-berlin.de or presse@mdc-berlin.de

The Max Delbrck Center for Molecular Medicine in the Helmholtz Association (MDC) is one of the worlds leading biomedical research institutions. Max Delbrck, a Berlin native, was a Nobel laureate and one of the founders of molecular biology. At the MDCs locations in Berlin-Buch and Mitte, researchers from some 60 countries analyze the human system investigating the biological foundations of life from its most elementary building blocks to systems-wide mechanisms. By understanding what regulates or disrupts the dynamic equilibrium in a cell, an organ, or the entire body, we can prevent diseases, diagnose them earlier, and stop their progression with tailored therapies. Patients should benefit as soon as possible from basic research discoveries. The MDC therefore supports spin-off creation and participates in collaborative networks. It works in close partnership with Charit Universittsmedizin Berlin in the jointly run Experimental and Clinical Research Center (ECRC), the Berlin Institute of Health (BIH) at Charit, and the German Center for Cardiovascular Research (DZHK). Founded in 1992, the MDC today employs 1,600 people and is funded 90 percent by the German federal government and 10 percent by the State of Berlin.

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Maike Sander named to lead the Max Delbrck Center - EurekAlert

Ambys Medicines to Present Data from Universal Human Hepatocyte Program at the 2022 ISSCR Annual Meeting – Galveston County Daily News

Country

United States of America US Virgin Islands United States Minor Outlying Islands Canada Mexico, United Mexican States Bahamas, Commonwealth of the Cuba, Republic of Dominican Republic Haiti, Republic of Jamaica Afghanistan Albania, People's Socialist Republic of Algeria, People's Democratic Republic of American Samoa Andorra, Principality of Angola, Republic of Anguilla Antarctica (the territory South of 60 deg S) Antigua and Barbuda Argentina, Argentine Republic Armenia Aruba Australia, Commonwealth of Austria, Republic of Azerbaijan, Republic of Bahrain, Kingdom of Bangladesh, People's Republic of Barbados Belarus Belgium, Kingdom of Belize Benin, People's Republic of Bermuda Bhutan, Kingdom of Bolivia, Republic of Bosnia and Herzegovina Botswana, Republic of Bouvet Island (Bouvetoya) Brazil, Federative Republic of British Indian Ocean Territory (Chagos Archipelago) British Virgin Islands Brunei Darussalam Bulgaria, People's Republic of Burkina Faso Burundi, Republic of Cambodia, Kingdom of Cameroon, United Republic of Cape Verde, Republic of Cayman Islands Central African Republic Chad, Republic of Chile, Republic of China, People's Republic of Christmas Island Cocos (Keeling) Islands Colombia, Republic of Comoros, Union of the Congo, Democratic Republic of Congo, People's Republic of Cook Islands Costa Rica, Republic of Cote D'Ivoire, Ivory Coast, Republic of the Cyprus, Republic of Czech Republic Denmark, Kingdom of Djibouti, Republic of Dominica, Commonwealth of Ecuador, Republic of Egypt, Arab Republic of El Salvador, Republic of Equatorial Guinea, Republic of Eritrea Estonia Ethiopia Faeroe Islands Falkland Islands (Malvinas) Fiji, Republic of the Fiji Islands Finland, Republic of France, French Republic French Guiana French Polynesia French Southern Territories Gabon, Gabonese Republic Gambia, Republic of the Georgia Germany Ghana, Republic of Gibraltar Greece, Hellenic Republic Greenland Grenada Guadaloupe Guam Guatemala, Republic of Guinea, Revolutionary People's Rep'c of Guinea-Bissau, Republic of Guyana, Republic of Heard and McDonald Islands Holy See (Vatican City State) Honduras, Republic of Hong Kong, Special Administrative Region of China Hrvatska (Croatia) Hungary, Hungarian People's Republic Iceland, Republic of India, Republic of Indonesia, Republic of Iran, Islamic Republic of Iraq, Republic of Ireland Israel, State of Italy, Italian Republic Japan Jordan, Hashemite Kingdom of Kazakhstan, Republic of Kenya, Republic of Kiribati, Republic of Korea, Democratic People's Republic of Korea, Republic of Kuwait, State of Kyrgyz Republic Lao People's Democratic Republic Latvia Lebanon, Lebanese Republic Lesotho, Kingdom of Liberia, Republic of Libyan Arab Jamahiriya Liechtenstein, Principality of Lithuania Luxembourg, Grand Duchy of Macao, Special Administrative Region of China Macedonia, the former Yugoslav Republic of Madagascar, Republic of Malawi, Republic of Malaysia Maldives, Republic of Mali, Republic of Malta, Republic of Marshall Islands Martinique Mauritania, Islamic Republic of Mauritius Mayotte Micronesia, Federated States of Moldova, Republic of Monaco, Principality of Mongolia, Mongolian People's Republic Montserrat Morocco, Kingdom of Mozambique, People's Republic of Myanmar Namibia Nauru, Republic of Nepal, Kingdom of Netherlands Antilles Netherlands, Kingdom of the New Caledonia New Zealand Nicaragua, Republic of Niger, Republic of the Nigeria, Federal Republic of Niue, Republic of Norfolk Island Northern Mariana Islands Norway, Kingdom of Oman, Sultanate of Pakistan, Islamic Republic of Palau Palestinian Territory, Occupied Panama, Republic of Papua New Guinea Paraguay, Republic of Peru, Republic of Philippines, Republic of the Pitcairn Island Poland, Polish People's Republic Portugal, Portuguese Republic Puerto Rico Qatar, State of Reunion Romania, Socialist Republic of Russian Federation Rwanda, Rwandese Republic Samoa, Independent State of San Marino, Republic of Sao Tome and Principe, Democratic Republic of Saudi Arabia, Kingdom of Senegal, Republic of Serbia and Montenegro Seychelles, Republic of Sierra Leone, Republic of Singapore, Republic of Slovakia (Slovak Republic) Slovenia Solomon Islands Somalia, Somali Republic South Africa, Republic of South Georgia and the South Sandwich Islands Spain, Spanish State Sri Lanka, Democratic Socialist Republic of St. Helena St. Kitts and Nevis St. Lucia St. Pierre and Miquelon St. Vincent and the Grenadines Sudan, Democratic Republic of the Suriname, Republic of Svalbard & Jan Mayen Islands Swaziland, Kingdom of Sweden, Kingdom of Switzerland, Swiss Confederation Syrian Arab Republic Taiwan, Province of China Tajikistan Tanzania, United Republic of Thailand, Kingdom of Timor-Leste, Democratic Republic of Togo, Togolese Republic Tokelau (Tokelau Islands) Tonga, Kingdom of Trinidad and Tobago, Republic of Tunisia, Republic of Turkey, Republic of Turkmenistan Turks and Caicos Islands Tuvalu Uganda, Republic of Ukraine United Arab Emirates United Kingdom of Great Britain & N. Ireland Uruguay, Eastern Republic of Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Viet Nam, Socialist Republic of Wallis and Futuna Islands Western Sahara Yemen Zambia, Republic of Zimbabwe

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Ambys Medicines to Present Data from Universal Human Hepatocyte Program at the 2022 ISSCR Annual Meeting - Galveston County Daily News

Local Father Battling Cancer to Host Blood Stem Cell Drive at SH Sprint Triathlon – The Hudson Indy Westchester’s Rivertowns News – – The Hudson…

Eugene Doherty is a local fire captain and father of a nine-year-old daughter.

June 9, 2022

By Rick Pezzullo

A local fire department captain is on a mission to register potential stem cell donors to help others like himself who have been stricken with cancer.

Eugene Doherty, 46, is battling acute lymphoblastic leukemia (ALL) but was fortunate enough to find a matching donor in his family, which is not often the case for 70 percent of people suffering from blood-related illnesses who must seek a match from a stranger to save their life.

Originally from Ireland, Doherty resides in Sleepy Hollow and has volunteered for 12 years with the Sleepy Hollow Sprint Triathlon. Prior to his diagnosis, he was an active triathlete.

This weekend, Doherty is teaming up with DKMS, the worlds largest blood stem cell donor center, at Kingsland Point Park at 299 Palmer Ave. in Sleepy Hollow to try to register potential donors.

Anyone in good health between the ages of 18 and 55 is encouraged to attend. Potential registrants will review medical eligibility, fill out a registration form, swab the insides of their cheeks, and return their completed packet before leaving the drive. Anyone who cannot attend the registration drives can register by ordering a free swab kit viahttps://www.dkms.org/get-involved/virtual-drives/sleepy-hollow-sprint-triathlon-donor-drive.

The registration drive will take place Saturday, June 11 from 9 to 11 a.m. and Sunday, June 12 from 7 a.m. to noon.

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Bridge Therapy For Neuroblastoma: A Game-Changing Paediatric Cancer Treatment | TheHealthSite.com – TheHealthSite

Patients Suffering From Neuroblastoma May Benefit From Bridge Therapy

Written by Kinkini Gupta | Updated : June 9, 2022 12:31 PM IST

Neuroblastoma, a pediatric cancer that arises from immature nerve cells has a very high risk of recurrence among approximately half of the children who are already suffering from cancer. With ever-advancing medicine and technology, researchers however have discovered a new therapy called the 'bridge therapy.' A study conducted and published the journal Cancer states that patients suffering from neuroblastoma may benefit from this therapy between induction and consolidation treatments. Neuroblastoma can often be cured by surgical removal of tumors followed by chemotherapy. These patients often receive induction therapy composed of various drugs used to carry out chemotherapy and surgery. This is followed by consolidation therapy, which involves a high-dose chemotherapy and stem cell transplants. Unfortunately, these treatments, which are currently in use, have not been successful in many children.

This newly discovered therapy will include immunotherapy drugs that have demonstrated anti-neuroblastoma activity in combination with chemotherapy, radiolabeled MBIG or combinations of chemotherapeutic agents. Research suggests that this therapy could offer some benefit to cancer patients. To examine the effectiveness of this therapy, a study including the data from 201 patients diagnosed with neuroblastoma at various hospitals from 2008-2018 were taken into consideration. Some patients were treated in three groups with different approaches based on physician, institutional or family preferences. The three steps were:

This study was especially done to find out if patients are responding well to bridge therapy prior to consolidation with stem cell transplant. They found out that the following results with patients who directly underwent consolidation:

Response to induction therapy is known to increase survival rate, and the study suggests that bridge therapy prior to consolidation therapy benefits patients with high-risk neuroblastoma with a poor response to induction. Also, response to bridge therapy prior to consolidation therapy is associated with outcome, and patients with less than a partial response may benefit from alternative treatment approaches. An accompanying editorial discusses the findings and agrees that future studies of bridge therapy for patients who do not experience a favorable response following standard induction therapy are needed.

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Bridge Therapy For Neuroblastoma: A Game-Changing Paediatric Cancer Treatment | TheHealthSite.com - TheHealthSite

Expression of stem cell biomarkers Bmi1 and KLF4 in osteosarcoma and its clinical significance – Newswise

Abstract:

Objective To observe the expression of osteosarcoma stem cell biomarkers Bmi1 and KLF4 in osteosarcoma tissues and explore their value in the diagnosis, treatment and prognosis of osteosarcoma.

Methods Using retrospective research methods, 51 patients (28 males and 23 females) with osteosarcoma who were surgically resected and diagnosed by pathology in the Second Hospital of Shanxi Medical University from October 2009 to July 2019 were used as the experimental group. The age of cases varies from 10 to 67 (average 27.04) years old, and bone tissues adjacent to the tumor were taken from 10 samples as the normal control group. Immunohistochemical method was used to assess the expression levels of Bmi1 and KLF4 in 51 patients with osteosarcoma and 10 cases of paraneoplastic bone tissue specimens. Chi-square test was applied to analyze the relationship between the expression of Bmi1 and KLF4 and the clinical pathological data of patients. Correlation analysis was analyzed by the number of connections. The survival rate of patients was calculated by the Kaplan-Meier method. The log rank univariate analysis and Cox regression multivariate analysis were carried out to evaluate the prognostic value.

Results The positive expression rates of Bmi1 and KLF4 in the osteosarcoma group were 78.43% (40/51) and 80.39% (41/51), respectively, and in the bone tissue group were both 3/10. The difference of the positive expression rates of Bmi1 and KLF4 in the osteosarcoma group and bone tissue group was statistically significant (P < 0.05). In osteosarcoma group, the expression levels of Bmi1 and KLF4 were positively correlated (R = 0.399, P < 0.01). Bmi1 protein-positive, KLF4 protein-positive, and Bmi1 and KLF4 protein double-positive expression were statistically significant in Enneking surgical staging, lung metastasis, and pathological typing (all P < 0.05), but there was no statistically significant difference between different ages, genders, local recurrences, and tumor sizes (all P > 0.05).

Conclusion The expression of Bmi1 and KLF4 in osteosarcoma tissue was significantly higher than that in surrounding bone tissues, and their positive expression is a risk factor for the prognosis of patients with osteosarcoma.

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Expression of stem cell biomarkers Bmi1 and KLF4 in osteosarcoma and its clinical significance - Newswise

Experts see blood stem cell transplant as a curative treatment for thalassemia – India Today

Baby Bhushra Naqeeb, an 11-year-old girl who has suffered from thalassemia since the age of 6 months, recently suggested an allogeneic stem cell transplant as her only chance of survival after over 10 years of blood transfusion. Finally, with the support from the DKMS-BMST thalassemia programme, she underwent stem cell transplantation in October 2021 under Dr. Sachin Jadhav, HCG (HeathCare Global Enterprises Ltd.) group of hospitals. Post the transplant, Bhushra is able to lead a normal life as she also attends regular school.

India is also known as the Thalassemia capital of the world. The country has the largest number of children with thalassemia major with over 10,000 children born with it every year. According to the World Health Organisation (WHO), over four million Indians are thalassemia carriers and more than 1,00,000 are patients. Parents, who are usually asymptomatic, are the carriers of this disease and have a 25% chance of passing this disease to their children.

Patients suffering from thalassemia are required to undergo lifelong regular blood transfusions to maintain their hemoglobin levels. However, it can now be cured with stem cell transplantation.

THE ONLY CURE

Dr. Sunil Bhat, Director and Clinical Lead, Pediatric Hematology, Oncology and Blood & Marrow Transplantation, Narayana Health said, Thalassemia patients are mostly children who go through painful blood transfusion for several years in their life. Blood transfusions have their own challenges and risks for the patients. A stem cell transplantation is currently the only curative option available for this condition. Recent data shows a more than 90% success rate of stem cell transplantation in patients who have HLA (Human Leukocyte Antigen) matched stem cell donors.

In a blood stem cell transplant, stem cells are collected from the blood of the donors and transplanted into the thalassemia patient after their bone marrow has been destroyed. Only 30% of patients who need transplants have a fully HLA-matched donor in their family, while the rest of them depend on an unrelated donor.

Shobha Tuli, the founder of the NGO - Thalassemics India, President-Federation of Indian Thalassemia Associations, says At present, stem cell transplant is the only curative treatment available for Thalassemia patients. If not cured on time, such patients are dependent on blood transfusions all throughout their lives along with other expensive treatments & regular investigations. Thalassemia Bal Sewa Yojna is a unique project initiated by the Ministry of Health & Family Welfare, Govt. of India. Under this scheme, a patient can get financial aid up to Rs. 10 lakhs from Coal India Ltd. DKMS has offered us an opportunity to get free HLA tests done in the country. This enables the patients to check if they have a matched sibling.

LOW AWARENESS

There are around 270 million Thalassemia patients in the world but awareness about the disease is alarmingly less. Symptoms of Thalassemia usually start at 4 to 6 months of age and usually present with lethargy, poor feeding, progressive pallor, poor weight gain and sometimes vomiting and diarrhoea. On examination, the babies are pale and have liver and spleen enlargement.

Patrick Paul, CEO, DKMS BMST Foundation India, says, It is our mission to support blood cancer, and other blood disorders such as Thalassemia patients in India, for which we have initiated the DKMS-BMST Thalassemia programme. Under this programme, DKMS-BMST collaborates with local NGOs and transplantation clinics to organise camps where paediatric thalassemia patients and their siblings travelling from afar places in India to give buccal swab samples for free HLA typing. Samples from the camps are analysed in the DKMS laboratory based out of Germany and clinical matching reports of the same are provided. In cases where there is no matching sibling for a sick child, we also support unrelated donor searches for patients. Since the inception of the programme, so far, 7,162 HLA typings have been facilitated by DKMS-BMST.

HOW YOU CAN HELP

Dr. Bhat also added, A successful blood stem cell transplant depends on a perfect HLA tissue match. Patients and donors of Indian origin have unique HLA characteristics that are severely under-represented in the global database, which makes the probability of finding a suitable donor even more difficult. Indian patients mainly require an Indian tissue match. This calls for increased awareness and the need to encourage many more people in India to register as potential blood stem cell donors.

To register as a potential blood stem cell donor, healthy individuals between 18-50 years of age can register at: dkms-bmst.org/register

All it takes is five minutes of your time and a simple 3-step process:

Step 1: Visit the site, fill in an online form and you will receive a DIY swab kit at home.

Step 2: Once you receive the swab kit, fill out the consent form and take a tissue sample from the inside of your cheeks with 3 cotton swabs provided in the kit.

Step 3: Send back your swab sample in the pre-paid envelope provided.

The DKMS laboratory will then analyse your tissue type and your details will be available in the global search for blood stem cell donors. If you do come up as a suitable donor, DKMS-BMST will get in touch with you straight away. Once you come up as a match, blood stem cells will be obtained from the bloodstream using a procedure called Peripheral Blood Stem Cell Collection, which is similar to a blood donation wherein only your stem cells are taken. This is a safe, non-surgical outpatient procedure.

READ MORE | JNU biologists identify a new way to better treat kala-azar

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Experts see blood stem cell transplant as a curative treatment for thalassemia - India Today

Sleep deprivation may increase the risk of eye disease – Medical News Today

While scientists know that sleep deprivation has a negative effect on the body, they are still researching how it affects different organs.

Researchers from China and the U.S. recently published a study in Stem Cell Reports on how poor sleep can affect the eyes. They found that sleep deprivation can affect both stem cells in the cornea and the tear film surface of the cornea.

Getting a good nights sleep on a regular basis is important, but according to the Centers for Disease Control and Prevention (CDC), more than one-third of adults dont get enough sleep. Doctors recommend that adults get at least 7 hours of sleep per night.

The CDC reports that not getting enough sleep can cause a myriad of health issues, such as having a higher risk for obesity, developing diabetes, and high blood pressure.

Part of the issue contributing to so many people not getting enough rest is having a sleep disorder. The National Institutes of Health reports that around 40 million Americans have a sleep disorder.

Some sleep disorders include:

For those who are not affected by a sleep disorder, the best way to regularly get enough sleep is to practice good sleep hygiene. People can accomplish this by going to bed at the same time every night, avoiding screens 1-2 hours before bed, and not drinking alcohol before bed.

The researchers in this study used mice to learn more about how sleep deprivation affects the eyes.

According to the authors, the cornea is the clear front surface of the eye. They also write that the cornea has an overlying tear film that helps keep the eyes comfortable and offers protection against infection.

The researchers were interested to find out to what degree sleep deprivation may affect stem cells in the cornea.

As Dr. Neil Neimark, a board certified family physician in functional medicine who applies stem cell therapy in his practice, noted in a TEDx Talks podcast, stem cells have healing power and all tissue repair in the body is initiated by stem cells.

The researchers of the current study assessed gene expression in the mice after 2 days of sleep deprivation and then after 10 days of sleep deprivation.

At the 2-day point, the researchers found that 287 genes were significantly upregulated and 88 were downregulated in corneas. At the 10-day point, they saw 272 significantly upregulated genes and 150 downregulated genes.

The authors tested the mice after 1 and 2 months of further sleep deprivation and found that the transparency of the cornea was reduced and the ocular surface was rough.

While stem cells were upregulated in the sleep-deprived mice early on, it eventually led to what the authors referred to as an early manifestation of limbal stem cell deficiency. After being upregulated for so long, the stem cells became depleted.

Short-term consequences of insufficient sleep or delayed sleep cause ocular discomfort, including dryness, pain, pruritus, and hyperemia of the eye, the authors note.

Despite these issues, the authors observed that treating the mice with damaged corneas with eye drops containing antioxidants helped restore the eye health of the mice.

Dr. Howard R. Krauss, a surgical neuro-ophthalmologist and director of Neuro-Ophthalmology for the Pacific Neuroscience Institute at Providence Saint Johns Health Center in Santa Monica, CA, who was not involved in the study, spoke to Medical News Today about the findings.

The design of the study was to study chemical and cellular changes in the ocular surface of sleep-deprived mice, revealing indeed that there are damaging effects, which shed light on mechanisms which may be at play in human symptoms and disease, Dr. Krauss said.

While Dr. Krauss thought the study was helpful at showing how sleep deprivation can potentially affect humans, he noted a limitation.

A weakness of the study is the methodology by which sleep deprivation is induced in mice, who are in cages, perched on sticks to remain above a water-filled bottom when the mouse falls asleep, it falls into the water, immediately wakes up, and climbs back up onto the stick, Dr. Krauss explained.

Dr. Krauss said the method used to induce sleep deprivation raises the question of how much of the chemical and cellular change they observed was purely secondary to sleep deprivation and how much may be a stress reaction to the means by which sleep deprivation has been engineered.

Nonetheless, the study refocuses our attention on sleep deprivation and leads us to think that the scope of damaging effects of sleep deprivation may be far [broader] than we realize, he said.

As such, the human need for sleep for maintenance of good health becomes more obvious every day. Dr. Howard R. Krauss

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Sleep deprivation may increase the risk of eye disease - Medical News Today