First really effective treatment for multiple sclerosis could be available within five years – iNews

At the moment, treatments help alleviate the symptoms of relapsing-remitting MS, the milder, more common form of the disease (Photo: LINDSEY PARNABY/AFP/Getty)

The first really effective treatment for multiple sclerosis (MS) could be available within five years after researchers raised hopes that they had discovered the holy grail of MS therapy.

Scientists have identified a natural mechanism in the body that could be boosted with an existing diabetes drug to protect against the nerve damage at the centre of the disease.

This would not only halt progression of MS but may partially reverse it as well, they say.

At the moment, treatments help alleviate the symptoms of relapsing-remitting MS, the milder, more common form of the disease although these do little to slow its progression.

Meanwhile, there are no treatments for the more serious form of the condition, known as Primary Progressive MS.

This is an incredibly important discovery one we believe could finally bridge the gap in MS treatment, said Don Mahad, of the University of Edinburgh.

Despite major advances in scientific understanding of MS in the past two decades, there is still no treatment to protect nerve fibres although that could be about to change, Dr Mahad said.

Such protection is the holy grail in MS treatment not only for the relapsing form of MS, which has various options available, but for progressive forms too, where treatment continues to lag behind, he said.

Tests on mice and human cells in a lab suggest the Pioglitazone diabetes drug would be a highly effective treatment.

The drug is now being trialled in humans and Dr Mahad is hopeful that it could be available on the health service within four to five years although he cautions more research is needed to confirm early findings.

Emma Gray, of the MS Society, which part-funded the research, said finding treatments for everyone with MS is now a very real prospect.

We can see a future where nobody needs to worry about MS getting worse.MS treatment could in the near future look completely different, Dr Gray said.

To stop multiple sclerosis from progressing we need treatments that protect nerves from damage a goal that has proved elusive.

In MS the protective coating that surrounds nerves, known as myelin, is damaged and nerves become less energy efficient as a result. Not having the energy they need makes nerves vulnerable to further damage and causes disability over time.

But for the first time researchers have discovered a natural mechanism in the body that tackles this issue. Our discovery shows that nerves respond to myelin damage by increasing the movement of mitochondria the cell powerhouse, which produces energy to the area of damage, said Don Mahad, of Edinburgh University. The researchers are calling the response ARMD, which stands for axonal response of mitochondria to demyelination.

Remarkably, we were able to enhance ARMD and protect these vulnerable nerves using the readily available diabetes drug pioglitazone, said Dr Mahad.

Over the last few decades there have been huge strides in our understanding of MS, and there are now over a dozen effective treatments for people with relapsing MS but these only address damage caused by the immune system. In order to truly stop MS and treat everyone, we need to find ways to both protect nerves from further injury and repair damaged myelin, Dr Mahad said. This is where the new discovery comes in.

The study was welcomed by experts not involved in the research.

This is an important study for our understanding of multiple sclerosis [and] might be an important step towards the development of neuroprotective treatment strategies a major unmet need in multiple sclerosis, said Professor Martin Kerschensteiner of the University of Munich.

The paper, published in Acta Neuropathologica, involved scientists from 15 universities and hospitals around the world.

They include Wellcome Trust-MRC Cambridge Stem Cell Institute, Queen Mary University of London, University of College London, Biomedical Primate Research Centre in the Netherlands, the Mayo College of Medicine and Science in Rochester, US, and the Ohio State University.

The MS Society said that more than 130,000 people in the UK live with the condition, which can be relentless, painful and disabling.

Like any responsible medical association, the MS Society takes great care not to raise false hopes where treatments are concerned.

So when it announces new research with the headline Holy Grail discovery to prevent disability in multiple sclerosis you know its something to take seriously.

Not that the discovery will automatically lead to a breakthrough MS treatment as the society would be the first to acknowledge since many more tests are required to confirm early promise.

But there is definitely a high degree of excitement around the development.

A further stroke of luck is that a potentially effective drug is already available for diabetes.

This reduces the need for extensive safety trials and should speed up the process by which the drug should become available assuming it is found to be effective in large human trials.

All going well and that is by no means a certainty we could see the drug being prescribed for MS within five years, researchers say.

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First really effective treatment for multiple sclerosis could be available within five years - iNews

Evolution and Expansion of Therapies in the Global Cell and Gene Therapy Tools and Reagents Market 2020-2024 – PRNewswire

DUBLIN, Aug. 4, 2020 /PRNewswire/ -- The "Cell and Gene Therapy Tools, and Reagents: Global Markets" report has been added to ResearchAndMarkets.com's offering.

Gene and cell therapy are emerging as important tools to treat human health. Techniques such as CAR-T therapy have emerged as key ways of treating many different types of cancers. The promise of gene therapy using technologies such as CRISPR is starting to be realized in clinical trials, and markets are scaling up to treat other diseases as well, particularly rare gene-based diseases. As these therapies are coming to the fore, a new market for tools to develop these therapies using standard methodologies is emerging. This report will cover what those tools are, how they impact the larger life science tools market, and how they will evolve over the next five years.

The scope of this study encompasses an investigation of the market's cell and gene therapy tools such as GMP proteins, media, cell separation and activation reagents, viral and non-viral, cytokine release syndrome monitoring products, GMP antibodies, leukapheresis instrumentation, immunoassays (multiplex and singleplex) and bioreactors. This research analyzes each tool type, determines its current market status, examines its impact on future markets, and presents forecasts of growth over the next five years. Technological issues, including the latest trends, are discussed. The report analyzes the industry on a worldwide basis, from both application and demand perspectives, in the major regions of the world.

The Report Includes:

Key Topics Covered:

Chapter 1 Introduction

Chapter 2 Summary and Highlights

Chapter 3 Market and Technology Background

Chapter 4 Market Breakdown by Region

Chapter 5 Market Breakdown by End User

Chapter 6 Government Regulations

Chapter 7 Patent Review/New Developments

Chapter 8 Analysis of Market Opportunities

Chapter 9 Company Profiles

For more information about this report visit https://www.researchandmarkets.com/r/p5fqx6

About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.

Media Contact:

Research and Markets Laura Wood, Senior Manager [emailprotected]

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Evolution and Expansion of Therapies in the Global Cell and Gene Therapy Tools and Reagents Market 2020-2024 - PRNewswire

After season full of injury and struggle, Brooks Koepka ready to defend titles at PGA Championship – Yahoo News Australia

Brooks Koepka is looking for his third consecutive win at the PGA Championship this week, which would cap an impressive stretch at major championships for him over the past two years.

This time around, however, the situation is vastly different.

Not only does this years event at TPC Harding Park in San Francisco mark the first major championship of the season a result of the COVID-19 pandemic but Koepka has been battling back from a persistent knee injury that hasnt improved much at all.

While its been a long time coming, Koepka said on Tuesday that he feels his game is finally in a good place something he proved to himself last week at the World Golf Championships-FedEx St. Jude Invitational.

My game feels like its in really, really good shape right now, Koepka said. I like the way Im hitting it Every day is a lot more comfortable. Im excited. This is a big boy golf course. Have to hit the ball straight. Got to put it in the fairway. Its going to play long. I think it kind of plays into my hands.

Koepka underwent a stem cell treatment to repair a partially torn patella tendon in his left knee right after the Tour Championship last season, though he re-tore the tendon a few months later in October after slipping on wet concrete at The CJ Cup in South Korea.

He has tried to play through it since play resumed, though has complained about his knee several times. At one point last month, he even said that nothing had improved at all since October. Koepka has long been against sitting out of the season or undergoing treatment now, however, rather opting to attempt to make a late season push.

I got frustrated. I think anybody would, Koepka said. Nobody likes playing bad. But at the same time, I knew it was only a couple swings away.

That push finally seemed to come to fruition last week in TPC Southwind.

After a pair of missed cuts and two finishes outside the top-30 since play resumed in June, Koepka was in position to win throughout the WGC-FedEx St. Jude Invitational and finished in a tie for second his best finish of the year. His performance jumped him 59 spots in the FedExCup standings, too, more than enough to get him in the field for the first FedExCup Playoffs event.

Just to be in contention I thought was nice I feel great, he said. I think it was more about getting in contention again and just having those feelings back, which felt good.

With that under his belt, Koepka finally feels like hes peaking at just about the right time.

I felt like I was playing a little bit better, wasnt seeing the results, but piece by piece it was coming, Koepka said. I knew it was eventually going to be there. As far as confidence, I got frustrated. I think anybody would. Nobody likes playing bad.

But at the same time, I knew it was only a couple swings away. Once I got the feeling, Id be off and running, and here we are.

Brooks Koepka looks over a putt on the 17th green during the final round of the World Golf Championship-FedEx St. Jude Invitational at TPC Southwind on August 02, 2020. (Andy Lyons/Getty Images)

Koepka will tee off with Shane Lowry and Gary Woodland for the first two rounds this week. Though he may not like to admit it, a win for him in San Francisco would be historic.

Its been 64 years since someone has won a major championship three years in a row and only Walter Hagan has done so at the PGA Championship. Koepka nearly pulled off the feat at the U.S. Open last year, too, but finished just behind Woodland in second at Pebble Beach.

That experience, he said, has relieved any worry of winning three in a row.

And after the year hes had, Koepka said he isnt stressed headed into Thursdays opening round.

I dont put any expectations on myself, just go out and go play golf exactly like I know how, he said. If I do that, then yeah, I probably should win.

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After season full of injury and struggle, Brooks Koepka ready to defend titles at PGA Championship - Yahoo News Australia

The global cell and gene therapy market by revenue is expected to grow at a CAGR of over 30.90% during the period 20192025 – GlobeNewswire

August 04, 2020 09:13 ET | Source: ReportLinker

New York, Aug. 04, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Cell & Gene Therapy Market - Global Outlook and Forecast 2020-2025" - https://www.reportlinker.com/p05827567/?utm_source=GNW 90% during the period 20192025.

The global cell and gene therapy market is one of the fastest-growing segments in the regenerative medicine market. The market is expected to grow at a faster pace during the forecast period. The demand can be attributed to the growing prevalence of several chronic diseases such as cancer, cartilage related problems, wounds, diabetic foot ulcer, genetic disorders, and other rare diseases across the globe. The prevalence of cancer and diabetes is increasing in the global population, which is influencing the growth of the market. There is a large unmet need in the treatment available, which is filled by cell and gene therapies. The market is growing due to the increased availability of funding from various public and private institutions. Besides, there is increased support from regulatory bodies for product approval. Several governments are creating awareness of cell and gene therapies in the population.

The following factors are likely to contribute to the growth of the cell and gene therapy market during the forecast period: Increase in Strategic Acquisition Activities Increased Funding for Cell & Gene Therapy Products Expanding Applications of Cell and Gene Therapies Increased in the Patient Pool

The study considers the present scenario of the cell and gene therapy market and its market dynamics for the period 2019?2025. It covers a detailed overview of several market growth enablers, restraints, and trends. The report offers both the demand and supply aspects of the market. It profiles and examines leading companies and other prominent ones operating in the market. Cell And Gene Therapy Market Segmentation The global cell and gene therapy market research report includes a detailed segmentation by product, disease, end-user, and geography. In 2019, the cell therapy segment accounted for a market share of over 53% in the global cell and gene therapy market. The segment is expected to grow at a steady rate during the forecast period due to the increase in the target population and the rise in the number of countries preferring cell therapies in their patients. Increased therapeutic benefits are attracting several countries to invest in this technology and conduct a high number of clinical trials. However, the lack of advanced infrastructure in developing countries is hindering the growth of the segment.

In 2019, the oncology segment accounted for a share of over 40% in the global cell and gene therapy market. Oncology has been one of the targets of intense research for the gene therapy procedures & approach. More than 60% of on-going gene therapy clinical trials are targeting cancer. The segment is expected to grow at a promising rate on account of the high prevalence of cancer diseases, especially in low and middle-come countries. The market is growing at a double-digit CAGR, which is expected to help the segment as many cell and gene therapy for cancer are commercially available.

The dermatology application segment in the cell and gene therapy includes wound care management among patients. Vendors are focusing on the development and commercialization of advanced wound care products for the treatment of chronic and acute wounds, thereby increasing the growth of the wound care market. The increased pervasiveness of diabetics is increasing acute and chronic wounds, including surgical wounds, pressure ulcers, diabetic foot ulcers, and other wounds.

In 2019, the oncology segment accounted for a share of over 40% in the global cell and gene therapy market. Oncology has been one of the targets of intense research for the gene therapy procedures & approach. More than 60% of on-going gene therapy clinical trials are targeting cancer. The segment is expected to grow at a promising rate on account of the high prevalence of cancer diseases, especially in low and middle-come countries. The market is growing at a double-digit CAGR, which is expected to help the segment as many cell and gene therapy for cancer are commercially available.

The dermatology application segment in the cell and gene therapy includes wound care management among patients. Vendors are focusing on the development and commercialization of advanced wound care products for the treatment of chronic and acute wounds, thereby increasing the growth of the wound care market. The increased pervasiveness of diabetics is increasing acute and chronic wounds, including surgical wounds, pressure ulcers, diabetic foot ulcers, and other wounds.

Segmentation by Product Cell Therapy Gene Therapy Segmentation by Disease Dermatology Musculoskeletal Oncology Genetic Disorders Others Segmentation by End-user Hospitality Cancer Care Centers Wound Care Centers Ambulatory Surgical Centers Others

INSIGHTS BY GEOGRAPHY In 2019, North America accounted for a share of over 60% of the global cell and gene therapy market. There are more than 530 regenerative medicine companies, including cell and gene therapy manufacturing developers. The number of products approved in North America grew significantly in 2019, with developers filed for marketing authorization for 10+ regenerative medicines, many of which we expect to be approved in 2020. Within the next 12 years, the number of approved gene therapies is expected to double. The US and Canada are the major contributors to the cell and gene therapy market in North America. Regulatory bodies are supporting several investigational products, fast track approvals, RMAT designation for the faster approval of the product into the market. The alliance for regenerative medicine and Medicare and Medicaid is working together to bring the structured reimbursement channels for cell and gene therapies.

Segmentation by Geography North America o US o Canada Europe o UK o Germany o France o Spain o Italy APAC o China o Japan o South Korea o Australia o India Latin America o Brazil o Mexico Middle East & Africa o Saudi Arabia o Turkey o South Africa o UAE

INSIGHTS BY VENDORS The global cell and gene therapy market is highly dynamic and characterized by the presence of several global, regional, and local vendors offering a wide range of therapies. Dendreon, Gilead Sciences, Novartis, Organogenesis, Osiris Therapeutics, Vericel, Amgen, and Spark Therapeutics are the leading players in the market with significant shares. Vendors such as NuVasive, APAC Biotech, Nipro, Orthocell, bluebird bio, J-TEC, and Terumo are the other prominent players in the market with a presence, especially in the cell therapy market. Most leading players are focusing on implementing strategies such as product launches and approvals, marketing and promotional activities, acquisitions, increased R&D investments, and strengthening their distribution networks to enhance their share and presence in the market.

Prominent Vendors Gilead Sciences Spark Therapeutics Novartis Organogenesis Amgen Osiris Therapeutics Dendreon Vericel

Other Prominent Vendors Anterogen Tego Sciences Japan Tissue Engineering JCR Pharmaceuticals Medipost MolMed AVITA Medical CollPlant Biosolution Stempeutics Research Kolon Tissue Gene Orchard Therapeutics Sibiono GeneTech NuVasive Corestem Pharmicell Shanghai Sunway Biotech RMS Regenerative Medical System Takeda Pharmaceutical Company CHIESI Farmaceutici CO.DON AnGes GC Pharma Human Stem Cells Institute JW CreaGene APAC Biotech Nipro Terumo Orthocell bluebird bio

Key Questions Answered 1. What is the cell and gene therapy market size and growth rate during the forecast period? 2. What are the factors impacting the growth of the cell and gene therapy market share? 3. How is the growth of the healthcare segment affecting the growth of the cell and gene therapy market? 4. Who are the leading vendors in the cell and gene therapy market, and what are their market shares? 5. Which product type/ end-user type/region is generating the largest revenue in the Asia Pacific region? Read the full report: https://www.reportlinker.com/p05827567/?utm_source=GNW

About Reportlinker ReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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The global cell and gene therapy market by revenue is expected to grow at a CAGR of over 30.90% during the period 20192025 - GlobeNewswire

ReViral Announces FDA Fast Track Designation Granted to Sisunatovir For The Treatment of Serious Respiratory Syncytial Virus Infection – Business Wire

LONDON & RESEARCH TRIANGLE PARK, N.C.--(BUSINESS WIRE)--ReViral Ltd., a clinical-stage biopharmaceutical company focused on discovering, developing, and commercializing antiviral therapeutics that target respiratory syncytial virus (RSV), today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to sisunatovir for the treatment of patients with serious RSV infection. Sisunatovir is the companys most advanced product candidate, with two international multicentre Phase 2 clinical studies recently initiated in pediatric and high-risk adult patient populations.

We are very pleased that sisunatovir has received Fast Track designation for the treatment of serious RSV, a significant global health concern, said Alex Sapir, CEO, ReViral. RSV affects approximately 64 million people and causes approximately 160,000 deaths each year. We look forward to working closely with the FDA throughout the clinical development of this program with the goal of bringing a potentially life-saving treatment to patients as quickly as possible.

Fast Track is a process intended to facilitate the development and expedite the review of drug candidates that treat serious conditions and fill an unmet medical need. A drug candidate with Fast Track designation is eligible for greater access to the FDA for the purpose of expediting the drug product candidate's development, review, and potential approval.

Notes to Editors

About Sisunatovir

Sisunatovir is an orally administered fusion inhibitor designed to block RSV replication by inhibiting RSV F-mediated fusion of RSV with the host cell. Preclinical tests showed sisunatovir to have an excellent toxicity profile with an attractive therapeutic index. In Phase 1 clinical studies, sisunatovir showed excellent exposure with no serious adverse events being reported. In 2018, results from a Phase 2a challenge study in healthy adult volunteers were reported in which sisunatovir produced statistically significant reductions in viral load and clinical symptoms. ReViral has recently initiated two international multicentre Phase 2 clinical studies of sisunatovir in pediatric and adult high-risk patient populations.

About Respiratory Syncytial Virus (RSV)

RSV is a respiratory pathogen that can lead to severe and life-threatening lower respiratory tract infections, or LRTIs, in high-risk populations, such as infants, immunocompromised patients, and the elderly. RSV constitutes a substantial disease burden. The US-based National Institute of Health (NIH) estimates that, globally, RSV affects approximately 64 million people and causes approximately 160,000 deaths each year. Globally, there are an estimated 33 million cases of RSV LRTI each year in children younger than five years of age, with about 3 million of them being hospitalized and approximately 60,000 dying each year from complications associated with the infection. Currently, there are no effective therapeutic treatment options for patients who develop RSV infection.

About ReViral

ReViral is a clinical-stage biopharmaceutical company focused on discovering, developing, and commercializing antiviral therapeutics, with an initial focus on the treatment of respiratory syncytial virus (RSV). The companys lead product candidate, sisunatovir, is an orally administered fusion inhibitor currently being evaluated in two global Phase 2 clinical studies: one in a pediatric patient population and the other in an adult stem-cell transplant patient population. In addition, the company has an N-protein inhibitor program in late preclinical development. Both programs were discovered in-house and the company has retained worldwide development and commercialization rights.

For more information, please visit http://www.reviral.com

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ReViral Announces FDA Fast Track Designation Granted to Sisunatovir For The Treatment of Serious Respiratory Syncytial Virus Infection - Business Wire

Janssen Announces Health Canada Approval of DARZALEX* SC, a New Subcutaneous Formulation for the Treatment of Patients with Multiple Myeloma – Canada…

DARZALEX SC reduces administration time from hours to minutes and demonstrates consistent efficacy with a reduction in administration-related reactions compared to intravenous DARZALEX (daratumumab)

TORONTO, Aug. 4, 2020 /CNW/ - The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that Health Canada has approved DARZALEX SC (daratumumab), a new subcutaneous formulation of daratumumab.1 DARZALEX SC is approved in four regimens across five indications in patients with multiple myeloma, most notably newly diagnosed, transplant-ineligible patients as well as relapsed or refractory patients. As a fixed-dose formulation, DARZALEX SC can be administered over approximately three to five minutes, significantly less time than intravenous (IV) DARZALEX, which is administered over hours.2 DARZALEX SC is the only subcutaneous CD38-directed antibody approved in the treatment of multiple myeloma.

In the Phase 3 COLUMBA study published in The Lancet, DARZALEX SC demonstrated a consistent overall response rate (ORR) and pharmacokinetics and a similar safety profile compared with IV DARZALEXin patients with relapsed or refractory multiple myeloma. In addition, there was a nearly two-thirds reduction in systemic administration-related reactions (ARRs) for DARZALEX SC compared to IV DARZALEX(13 per cent vs. 34 per cent, respectively).3

"DARZALEX has become a backbone therapy in the treatment of multiple myeloma, supported by a robust body of evidence in both the frontline and relapsed and refractory settings," says Dr. Darrell White, Hematologist, Queen Elizabeth II Health Sciences Centre, Halifax. "With this new subcutaneous formulation, not only is treatment much more convenient for patients, but it will also play a very important role in reducing wait times and the burden on our busy healthcare system, especially during this time."

The approval is based on data from the Phase 3 COLUMBA and Phase 2 PLEIADES studies.4,5In the COLUMBA study, the ORR was non-inferior for patients taking DARZALEX SC as monotherapy compared to those taking IV DARZALEXas monotherapy (41 per cent vs. 37 per cent, respectively).6 Additionally, in the Phase 2 PLEIADES study evaluating the efficacy and safety of DARZALEXSC in combination therapies, objective responses were demonstrated in combination with bortezomib, melphalan and prednisone (D-VMP) in newly diagnosed transplant ineligible patients. In addition, objective responses were demonstrated in combination with lenalidomide and dexamethasone (D-Rd) in relapsed or refractory patients who received one prior line of therapy.7In a pooled safety population of 490 patients who received DARZALEXSC as monotherapy or in combination, the ARR rate was 11 per cent.8

DARZALEX SC is approved in all current IV indicationsincluding (1) in combination with bortezomib, melphalan and prednisone in newly diagnosed patients who are ineligible for autologous stem cell transplant, (2) in combination with lenalidomide and dexamethasone in newly diagnosed patients who are ineligible for autologous stem cell transplant and in patients with relapsed or refractory multiple myeloma who have received at least one prior therapy, (3) in combination with bortezomib and dexamethasone in patients who have received at least one prior therapy, and (4) as monotherapy, in patients who have received at least three prior lines of therapy including a proteasome inhibitor (PI) and an immunomodulatory agent or who are double-refractory to a PI and an immunomodulatory agent.9

Active discussions are ongoing with public insurers to determine how DARZALEX SC can be made accessible for both relapsed or refractory patients as well as newly diagnosed, transplant ineligible patients.

"This approval exemplifies Janssen's mission and commitment to bringing together passion, science and ingenuity to advance novel solutions for patients," said Mathai Mammen, M.D., Ph.D., Global Head, Janssen Research & Development, LLC.

About the COLUMBA Study The randomised, open-label, multicenter Phase 3 COLUMBA study included 522 patients (median age of 67 years) with multiple myeloma who had received at least three prior lines of therapy including a proteasome inhibitor (PI) and an immunomodulatory drug (IMiD), or whose disease was refractory to both a PI and an ImiD. In the arm that received DARZALEX SC (n=263), patients received a fixed dose of DARZALEX SC 1,800 milligrams (mg), co-formulated with recombinant human hyaluronidase PH20 (rHuPH20) 2,000 Units per milliliter (U/mL), subcutaneously weekly for Cycles 1 2, every two weeks for Cycles 3 6 and every four weeks for Cycle 7 and thereafter. In the IV DARZALEXarm (n=259), patients received DARZALEXfor IV infusion 16 milligrams per kilogram (mg/kg) weekly for Cycles 1 2, every two weeks for Cycles 3 6 and every four weeks for Cycle 7 and thereafter. Each cycle was 28 days. In the arm that received DARZALEX SC, it was given in a fixed volume of 15 mL over three to five minutes; the median injection time was five minutes. In the arm that received the IV administration, the median durations of the first, second and subsequent IV DARZALEXinfusions were 7.0, 4.3 and 3.4 hours, respectively. Patients in both arms continued treatment until disease progression or unacceptable toxicity.10,11

About the PLEIADES Study The non-randomised, open-label, parallel assignment Phase 2 PLEIADES study included adults with multiple myeloma, including 67 patients with newly diagnosed multiple myeloma who were treated with 1,800 mg of DARZALEX SC in combination with bortezomib, melphalan, and prednisone (D-VMP) and 65 patients with relapsed or refractory disease who were treated with 1,800 mg of DARZALEX SC plus lenalidomide and dexamethasone (D-Rd). The primary endpoint for the D-VMP and D- Rd cohorts was overall response rate.12

About DARZALEXand DARZALEX SCDARZALEX is the first CD38-directed monoclonal antibody (mAb) approved to treat multiple myeloma and in 2020, DARZALEX SC (daratumumab) follows as the only subcutaneous CD38-directed antibody approved to treat patients with multiple myeloma.13It binds to CD38,a surface protein highly expressed across multiple myeloma cells.14 DARZALEX induces tumor cell death through cell lysis via multiple immune-mediated mechanisms of action, including complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP).15DARZALEX has also demonstrated immunomodulatory effects such as increasing CD4+ and CD8+ T-cells counts, which may contribute to clinical response.16

In August 2012, Janssen Biotech, Inc. and Genmab A/S entered a worldwide agreement, which granted Janssen an exclusive license to develop, manufacture and commercialize DARZALEX. Janssen Inc. commercializes DARZALEX and DARZALEX SC in Canada. For full Prescribing Information and more information about DARZALEX and DARZALEX SC, please visit http://www.janssen.com/canada.

About Multiple MyelomaMultiple myeloma is an incurable blood cancer that affects a type of white blood cell called plasma cells, which are found in the bone marrow.17 When damaged, these plasma cells rapidly spread and replace normal cells with tumors in the bone marrow. In 2020, it is estimated that 3,400 Canadians will be diagnosed with multiple myeloma and there will be 1,600 deaths associated with the disease.18 While some patients with multiple myeloma have no symptoms in the early stages, patients are diagnosed due to symptoms that can include bone disease or pain, anemia, calcium elevation, and kidney problems.19

About the Janssen Pharmaceutical Companies of Johnson & Johnson At Janssen, we're creating a future where disease is a thing of the past. We're the Pharmaceutical Companies of Johnson & Johnson, working tirelessly to make that future a reality for patients everywhere by fighting sickness with science, improving access with ingenuity, and healing hopelessness with heart. We focus on areas of medicine where we can make the biggest difference: Cardiovascular & Metabolism, Immunology, Infectious Diseases & Vaccines, Neuroscience, Oncology, and Pulmonary Hypertension.

Learn more at http://www.janssen.com/canada. Follow us at @JanssenCanada. Janssen Inc. is a member of the Janssen Pharmaceutical Companies of Johnson & Johnson.

*All trademark rights used under license. **Dr. White was not compensated for any media work. He has been compensated as a consultant.

Cautions Concerning Forward-Looking StatementsThis press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995 regarding DARZALEX SC. The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of Janssen Inc., any of the other Janssen Pharmaceutical Companies and/or Johnson & Johnson. Risks and uncertainties include, but are not limited to: challenges and uncertainties inherent in product research and development, including the uncertainty of clinical success and of obtaining regulatory approvals; uncertainty of commercial success; manufacturing difficulties and delays; competition, including technological advances, new products and patents attained by competitors; challenges to patents; product efficacy or safety concerns resulting in product recalls or regulatory action; changes in behavior and spending patterns of purchasers of health care products and services; changes to applicable laws and regulations, including global health care reforms; and trends toward health care cost containment. A further list and descriptions of these risks, uncertainties and other factors can be found in Johnson & Johnson's Annual Report on Form 10-K for the fiscal year ended December 29, 2019, including in the sections captioned "Cautionary Note Regarding Forward-Looking Statements" and "Item 1A. Risk Factors," and in the company's most recently filed Quarterly Report on Form 10-Q, and the company's subsequent filings with the Securities and Exchange Commission. Copies of these filings are available online at http://www.sec.gov, http://www.jnj.com or on request from Johnson & Johnson. None of the Janssen Pharmaceutical Companies nor Johnson & Johnson undertakes to update any forward-looking statement as a result of new information or future events or developments.

References:

1

[DARZALEX SC Product Monograph, Janssen Inc., July 29, 2020]

2

[DARZALEX SC Product Monograph, Janssen Inc., July 29, 2020]

3

Mateos MV, et al. Subcutaneous versus intravenous daratumumab in patients with relapsed or refractory multiple myeloma (COLUMBA): a multicentre, open-label, non-inferiority, randomised, phase 3 trial [published online ahead of print March 23, 2020]. Lancet Haematol doi.org/10.1016/S2352-3026(20)30070-3.

4

Mateos M-V et al. Efficacy and Safety of the Randomized, Open-Label, Non-inferiority, Phase 3 Study of Subcutaneous (SC) Versus Intravenous (IV) Daratumumab (DARA) Administration in Patients (pts) With Relapsed or Refractory Multiple Myeloma (RRMM): COLUMBA. 2019 American Society of Clinical Oncology Annual Meeting. June 2019.

5

Janssen Research & Development, LLC. A Study to Evaluate Subcutaneous Daratumumab in Combination With Standard Multiple Myeloma Treatment Regimens. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000 [cited July 5, 2019]. Available at: https://clinicaltrials.gov/ct2/show/NCT03412565. Identifier: NCT03412565.

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Mateos MV, et al. Subcutaneous versus intravenous daratumumab in patients with relapsed or refractory multiple myeloma (COLUMBA): a multicentre, open-label, non-inferiority, randomised, phase 3 trial [published online ahead of print March 23, 2020]. Lancet Haematol doi.org/10.1016/S2352-3026(20)30070-3.

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Chari A, M. J., McCarthy H, et al Subcutaneous daratumumab plus standard treatment regimens in patients with multiple myeloma across lines of therapy: PLEIADES study update. Poster presented at: 61st American Society of Hematology (ASH) Annual Meeting. Orlando, FL.

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[DARZALEX SC Product Monograph, Janssen Inc., July 29, 2020]

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[DARZALEX SC Product Monograph, Janssen Inc.,July 29, 2020]

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[DARZALEX SC Product Monograph, Janssen Inc., July 29, 2020]

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Mateos MV, et al. Subcutaneous versus intravenous daratumumab in patients with relapsed or refractory multiple myeloma (COLUMBA): a multicentre, open-label, non-inferiority, randomised, phase 3 trial [published online ahead of print March 23, 2020]. Lancet Haematol doi.org/10.1016/S2352-3026(20)30070-3.

12

Janssen Research & Development, LLC. A Study to Evaluate Subcutaneous Daratumumab in Combination With Standard Multiple Myeloma Treatment Regimens. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000 [cited July 5, 2019]. Available at: https://clinicaltrials.gov/ct2/show/NCT03412565. Identifier: NCT03412565.

13

Janssen Research & Development, LLC. A Study to Evaluate Subcutaneous Daratumumab in Combination With Standard Multiple Myeloma Treatment Regimens. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000 [cited July 5, 2019]. Available at: https://clinicaltrials.gov/ct2/show/NCT03412565. Identifier: NCT03412565.

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[DARZALEX SC Product Monograph, Janssen Inc., July 29, 2020]

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[DARZALEX SC Product Monograph, Janssen Inc., July 29, 2020]

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[DARZALEX SC Product Monograph, Janssen Inc., July 29, 2020]

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Kumar, SK et al. Risk of progression and survival in multiple myeloma relapsing after therapywith IMiDs and bortezomib: a multicenter international myeloma working group study. Leukemia. 2012 Jan; 26(1):149-57.

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Canadian Cancer Society. "Signs and Symptoms of Multiple Myeloma." Available at: https://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/statistics/?region=on.Accessed June 2020.

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Canadian Cancer Society. "Signs and Symptoms of Multiple Myeloma." Available at: http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/signs-and-symptoms/?region=on.Accessed June 2020.

SOURCE Janssen Inc.

For further information: Media Contact: Janssen Inc., Jennifer McCormack, Office: (416) 382-5121; Investor Contact: Jennifer McIntyre, Office: (732) 524-3922

http://www.janssen.ca/

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Janssen Announces Health Canada Approval of DARZALEX* SC, a New Subcutaneous Formulation for the Treatment of Patients with Multiple Myeloma - Canada...

Sernova Enters into Exclusive Worldwide License Agreement with University of Miami for Therapeutic Cell Immune Protection Technologies -…

Sernova expands its intellectual property portfolio and capabilities to develop first-in-class cell therapy solutions for type 1 diabetes and other chronic diseases that eliminate the need for life-long immunosuppression drugs

LONDON, ONTARIO - August 4, 2020 - Sernova Corp. (TSXV:SVA) (OTC:SEOVF) (FSE:PSH), a clinical-stage regenerative medicine company developing a 'functional cure' for type 1 diabetes and other chronic diseases, announced today it has entered into an exclusive, worldwide license with the University of Miami at Coral Gables, Florida, for the commercial rights to novel conformal coating immune protection technologies. The technologies were developed by Dr. Alice Tomei, Dr. Jeffrey Hubbell, and Aaron Stock (Graduate Student). Dr. Tomei is a leading international expert in immunoprotection and diabetes immunoengineering, of the renowned Diabetes Research Institute (DRI), a designated Center of Excellence at the University of Miami Miller School of Medicine. Dr. Hubbell is the Eugene Bell Professor of Tissue Engineering at the University of Chicago and leading international researcher in immunoengineering.

This exclusive worldwide license agreement is important to Sernova because it broadens the technology scope of Sernova's immune protection conformal coating technologies and related intellectual property. Furthermore, it adds to a series of recent strategic acquisitions and collaborations for the Company and builds on our goal of protecting Sernova's therapeutic cells or tissues transplanted into Sernova's Cell Pouch(TM) from a detrimental auto-immune system response while eliminating the need for immunosuppressive drugs in treated patients.

"Sernova is further advancing development of its novel Cell Pouch System(TM) as a therapeutic platform to provide cell therapy solutions to patients with chronic diseases, such as type 1 diabetes, without the current need for life-long immunosuppressive drugs. We believe, with the addition of local immune protection, our breakthrough technologies will have the potential to significantly expand access to and the availability of therapeutic solutions to millions of people as a 'functional cure' for the chronic diseases from which they are suffering," said Dr. Philip Toleikis, President and CEO of Sernova Corp.

Dr. Toleikis continued, "As we continue to advance our first-in-class technologies, we have diligently selected complementary technologies developed by recognized experts in the field such as those by Dr. Tomei and colleagues to add to our Cell Pouch(TM) platform. With the continued expansion of our regenerative medicine therapeutics platform, we are positioning the Company at the forefront in the development of safe, functional regenerative medicine therapeutics."

Dr. Alice Tomei, the Director of the Islet Immunoengineering Laboratory at DRI stated, "Following my postdoctoral training in Dr. Hubbell's laboratory at Ecole Polytechnique Federale de Lausanne, Switzerland, I joined the University of Miami where I have focussed my academic career in the pursuit and development of novel cellular immune protection technologies to advance the field of cell therapy. With Sernova's goal of a 'functional cure' for diabetes, supported by its positive preclinical and more recent, emerging clinical safety and efficacy data from the University Chicago clinical trial, I am excited to contribute to the addition of local immune protection technologies provided by conformal coatings as the next important step towards this ultimate goal."

ABOUT SERNOVA CORP.

Sernova Corp is developing regenerative medicine therapeutic solutions using a medical device (Cell Pouch(TM)) and immune protected therapeutic cells/tissues (i.e., human donor cells, corrected human cells and stem cell-derived cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as insulin-dependent diabetes, blood disorders including hemophilia, and other diseases treated through cellular production of proteins or hormones missing or in short supply within the body. For more information, please visit http://www.sernova.com.

ABOUT SERNOVA'S CELL POUCH(TM) SYSTEM

The Cell Pouch(TM), as part of the Cell Pouch(TM) System, is a novel, proprietary, scalable, implantable macro- encapsulation device solution designed for the long-term survival and function of therapeutic cells. The device upon implantation is designed to incorporate with tissue, forming highly vascularized tissue chambers for the transplantation and function of therapeutic cells, which then release proteins and hormones as required to treat disease. The Cell Pouch(TM), along with therapeutic cells, has been shown to provide long-term safety and efficacy in small and large animal models of diabetes and has been proven to provide a biologically compatible environment for insulin-producing cells in humans in a Canadian first-in-human study. Sernova is currently conducting a Phase I/II study at the University of Chicago.

FOR FURTHER INFORMATION, PLEASE CONTACT:

Dominic Gray

Sernova Corp.

Tel: (519) 858-5126

dominic.gray@sernova.com

http://www.sernova.com

FORWARD-LOOKING INFORMATION

This release contains statements that, to the extent they are not recitations of historical facts, may constitute "forward-looking statements" that involve various risks, uncertainties, and assumptions, including, without limitation, statements regarding the prospects, plans, and objectives of the Company. Wherever possible, but not always, words such as "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects", "potential for" and similar expressions, or that events or conditions "will", "would", "may", "could" or "should" occur are used to identify forward-looking statements. These statements reflect management's beliefs with respect to future events and are based on information currently available to management on the date such statements were made. Many factors could cause Sernova's actual results, performances or achievements to not be as anticipated, estimated or intended or to differ materially from those expressed or implied by the forward-looking statements contained in this news release. Such factors could include, but are not limited to, the Company's ability to secure additional financing and licensing arrangements on reasonable terms, or at all; ability to conduct all required preclinical and clinical studies for the Company's Cell Pouch System and/or related technologies, including the timing and results of those trials; ability to obtain all necessary regulatory approvals, or on a timely basis; ability to in-license additional complementary technologies; ability to execute its business strategy and successfully compete in the market; and the inherent risks associated with the development of biotechnology combination products generally. Many of the factors are beyond our control, including those caused by, related to, or impacted by the novel coronavirus pandemic. Investors should consult the Company's quarterly and annual filings available on http://www.sedar.com for additional information on risks and uncertainties relating to the forward-looking statements. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

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Fighting for a life unlimited with the Cystic Fibrosis Trust – Health Europa

Founded in 1964, the UKs Cystic Fibrosis Trust offers support and resources to patients affected by cystic fibrosis (CF), as well as funding research into treatments and the search for a cure for CF; and ensuring that CF patients can receive appropriate care and therapy. Cystic Fibrosis Trust Director of Research Dr Lucy Allen tells HEQ about the Trusts research strategy and the implications of precision treatment.

The Cystic Fibrosis Trust is the only UK charity dedicated to fighting for a life unlimited for everyone affected by CF. Cystic fibrosis is a genetic condition that affects the lungs, digestive system and other organs. It is caused by a faulty gene that controls the movement of salt and water in and out of cells, causing a buildup of thick, sticky mucus. There are more than 10,500 people living with CF in the UK; and one in 25 of us carries the faulty gene that causes it, usually without knowing. Living with CF means hours of nebulisers, physiotherapy and up to 60 tablets a day, just to stay healthy. Only half of those born with CF today are expected to live past 47 years.

Medication, physiotherapy and general health all must be considered when planning the simplest activity and being unwell can often interfere with work and education but we are fighting to overcome all those hurdles and are achieving great things through our investment in an exciting and dynamic portfolio of research and innovation. The Cystic Fibrosis Trust is the biggest charity funder of research specifically for the benefit of people with CF in the UK. New research is vital for discovering the next transformational breakthrough that will help deliver our vision of a life unlimited for all people affected by CF.

We have also established a groundbreaking Clinical Trials Accelerator Platform (CTAP) a UK-wide initiative bringing together cystic fibrosis (CF) centres, to increase participation and improve access to and delivery of high impact CF clinical trials. CTAP works with the CF community and informs them of relevant clinical trials and how they can take part in them, which is a crucial step in ensuring we get more new CF therapies and technologies to the market.

Much of this work is supported by the UK Cystic Fibrosis Registry: a secure centralised database, sponsored and managed by the Cystic Fibrosis Trust. The Registry records health data on consenting people with cystic fibrosis (CF) in England, Wales, Scotland and Northern Ireland. CF care teams enter data at every specialist centre and clinic across the UK, with over 99% of people with CF consenting to their data being submitted.

We also provide support to CF clinical teams in the NHS and support the continuous improvement of care that is provided across the UK, which is a fundamental role of the Cystic Fibrosis Trust. We also support and attract new talent into the field of CF care. The Trust provides up-to-date information, support and advice that enables even more people with CF to make the right choices for them at all stages of their lives; and our high impact campaigns for change are helping to influence key people in government and industry. Ultimately, we want everyone with CF to be in control of their own lives, and not have their conditions in control of them.

Our five-year research strategy, called putting the person into personalised medicine, was published in 2018. It sets out how our research investments will focus on research to deliver treatment and care that is tailored to everyone with cystic fibrosis (CF).

Cystic fibrosis is caused by mutations in the CFTR gene. Some effective treatments for people with specific mutations, known as precision medicines, have now been developed; and arrangements for access to the latest of these drugs, Kaftrio, are currently under discussion. For the latest updates on these ongoing discussions, please see the Life Saving Drugs area of our website at http://www.cysticfibrosis.org.uk.

These treatments could have a dramatic impact on the lives of people with CF (and have begun doing so already) by improving their life expectancy, reducing the number of lung infections and improving their quality of life. However, the era of precision medicines brings new challenges which the research strategy aims to help solve. The impact of taking these precision medicines will be different for everyone with cystic fibrosis. For example, older people with CF may have more lung damage, or complications such as CF-related diabetes (CFRD). This means that the way that their CF is managed will be unique to them, and treatments will need to reflect this. Were funding research to look at how treatments can be personalised to everyone with cystic fibrosis.

The development of precision medicines for people with CF is a huge leap forwards, but there are several reasons we shouldnt be complacent. More research is needed to determine whether CFTR modulators may be beneficial for more genotypes than they are currently approved for. To address this, we are working hard to assess whether people with other, rarer genotypes may also benefit from these drugs. Studies such as HIT-CF and research within the UK Cystic Fibrosis Innovation Hub will be important to determine this.

There is also room for improvement in the drugs that are licensed: by tweaking the drug design we could improve how they work and reduce the side effects, creating the next generation of precision medicines. To achieve this, we also need to continue lab-based biomedical research to increase our understanding of how the CFTR protein works and how it goes wrong in cystic fibrosis, and novel ways to restore its function.

Its also important to keep the interest of the drug companies involved, working with and supported by CTAP where appropriate, as they may decide to work on easier (and more profitable) disease areas if we dont. Importantly, we are still looking to develop drugs that would work for anyone with CF, whatever their genotype. This would be of particular benefit to people with rare mutations or those for whom the current drugs dont work or cause side effects.

In June of this year, we heard the exciting announcement from the European Medicines Agency (EMA) that they had found the CF drug Kaftrio safe and effective, meaning it can now progress towards being prescribed across Europe. Kaftrio is a triple-combination therapy made up of three different compounds, tezacaftor and ivacaftor (which together make up Symkevi) combined with elexacaftor.

Initially, Kaftrio is licensed for children and adults aged over 12 who have two copies of the F508del mutation, the most common CF causing mutation of the CFTR gene, or one copy of F508del and one copy of a minimal function mutation. The details of which precise genotypes the latter group covers is still to be confirmed. In addition, clinicians will be able to prescribe Kaftrio for certain patients with other rare mutations that are covered by the US Food and Drug Administrations (FDA) licensing decisions. We also expect that following completion of clinical trials, the drug licensing will expand availability to children under 12. Trials are actively being conducted in six- to 11-year-olds and the next step will be to conduct trials in children under six years old.

In clinical trials for Kaftrio, people with two copies of the F508del mutation had a 10% increase in lung function compared to treatment with Symkevi, and people with a single copy of F508del had more than a 14% increase in lung function compared to treatment with the placebo.

In England, NHS England have agreed a deal with the drugs manufacturer Vertex to facilitate access to Kaftrio from the first day the European licence is granted, which is expected to be later this summer or early autumn. Similarly, in Wales, the Health Minister also recently announced that a deal had been agreed for Kaftrio. We are continuing to work with all key stakeholders to ensure access to everyone in the UK who could benefit. In the first instance, that is seeking more information and updates about negotiations and access in Scotland, Northern Ireland, and the crown dependencies of Jersey, Guernsey, and the Isle of Man. We are also working to understand the mutations covered in the NHS England and NHS Wales deals and what flexibility clinicians will have in prescribing Kaftrio for people with rare or other mutations.

We are working with the UK Cystic Fibrosis Medical Association to support plans for rollout to ensure everyone can start Kaftrio as fast as clinically possible and we also support the UK CF Registry, which will continue its valuable work in monitoring the effectiveness of this drug, among many others.

At least three companies, including AbbVie, Proteostasis Therapeutics and Vertex Pharmaceuticals, are developing other potential triple combination therapies. Through our Clinical Trials Accelerator Platform, we are actively working to support the ongoing HIT-CF Europe research project which aims to provide better treatments for people with rare CF mutations who are currently ineligible for Kaftrio.

An important role for the CF Trust is to push the boundaries, demonstrating leadership and innovation to ensure research is excellent, timely and relevant. The ongoing development of our flagship research programmes, which include Strategic Research Centres, the Innovation Hub in CF Lung Health, the CF Syndicate in Antimicrobial Resistance, investments in digital health and CTAP, has enabled us to create a unique platform, placing the Trust in a strong position to facilitate research which addresses some of the key challenges that will confront healthcare over the next decade.

As the general population gets older, they start to become affected by a range of different diseases and conditions. The same will be true for people with cystic fibrosis. We know that people with CF may also be affected by conditions like cancer, diabetes, heart disease and social wellbeing, and perhaps in different ways to those who dont have cystic fibrosis. It is important to explore and better understand these multiple long term conditions, also a current priority for UK government, and to reduce their impact.

Rather than using drugs to correct the function of the CFTR protein, another area of research underway is looking to correct the CFTR gene itself, either by delivering healthy, non-mutated copies of the gene using gene therapy, or by correcting the existing damaged copy of the gene using gene editing. If this cutting-edge research is successful, future gene editing treatments for CF could either do on the job repairs to the cells that line the surface of the lungs, or the CF gene could be edited in cells in the lab and then corrected cells could be delivered back into the lungs. Whilst good progress is being made towards genetic-based treatments it is unlikely this will be available as a standard treatment for people with CF for many years. However, if they do become available, they could make a significant difference to everyone, irrespective of their genetic mutation.

People with CF can have a range of different lung infections, and its important to know which infections are present and how to treat them. Current post-licensing drug studies on the first of the CFTR modulators Ivacaftor showed that while people taking this modulator drug have fewer flare-ups of poor lung health and fewer infections, people are still susceptible to some infection, highlighting the importance of continuing investment in research to treat and understand lung infections in CF.

The earlier the infections are detected, the better chance there is of effectively treating them. Understanding how the bugs (bacteria, viruses and fungi) work can help researchers to identify possible druggable targets Increasingly these bugs are becoming resistant to antimicrobial therapies used to treat infections which means that better understanding and overcoming antimicrobial resistance is a key priority for CF, just as it is for public health globally.

As the lungs get more damaged, for many with CF a lung transplant may become the only treatment option, but there are sadly not enough donor lungs readily available. Researchers are investigating whether a combination of stem cell technology and gene editing could replace damaged lung cells, regenerating the lungs and providing an alternative to lung transplant.

The Cystic Fibrosis Trust supports a balanced portfolio of research, conducted within universities, private companies, hospitals and other healthcare settings around the world. The impact of the COVID-19 pandemic on Trust-funded research studies will vary on an individual study-by-study basis, and any true negative or positive impact is likely to emerge over time. As part of an ongoing dialogue with our grantees, we have put measures in place to try and protect both the research and the researchers we fund from the financial impact of COVID-19. We have encouraged all grantees to make use of the government-initiated financial support schemes where appropriate. We are also receiving regular updates on how or whether the pandemic has affected their ability to complete their research studies in a timely way.

COVID-19 has impacted on every area of life for many around the globe and has caused great deal of anxiety for many people with cystic fibrosis. In fact, many of the CF community will have been shielding to protect themselves from the risk of infection.

At the CF Trust, we are doing all we can to try and support people with CF and their families through this unprecedented time:

The UK Cystic Fibrosis Innovation Hub based at Cambridge University is a groundbreaking strategic partnership between the Cystic Fibrosis Trust and the University of Cambridge. Its aim is to harness multidisciplinary world class research to accelerate progress towards preventing lung damage in CF and subsequent loss of lung function. Its a five-year programme that began in 2018. The CF Trust aims to raise 5 million over the next five years for the Innovation Hub, which the University of Cambridge has already committed to match pound for pound to 5 million. In addition, the Innovation Hub has secured a physical presence for CF research in the new Heart and Lung Research Institute (HLRI) located close to Royal Papworth Hospital.

Increasingly CF bacterial infections are becoming resistant to these antibiotics, known as antimicrobial resistance or AMR, and it can become harder and harder to treat them. There is increasing concern worldwide about AMR; the UK Government has recently appointed the former Chief Medical Officer Dame Sally Davies as its Special Envoy on AMR, to raise its profile in the G7 and G20. Researchers within the Innovation Hub are designing new antibiotics to tackle AMR and to treat these serious CF infections from a first-principles approach. They are applying world-leading and cutting-edge methods to investigate the transmission of infection, and the biology of what makes Pseudomonas aeruginosa and Mycobacterium abscessus, two of the most aggressive bacterial infections in the CF lung, grow and survive.

They are aiming to combine all their approaches to design new, more effective antibiotics to deliver a shorter, more efficient eradication of bacteria and treatments that are harder for bacteria to develop resistance to. As many infections develop AMR, treating infections across the population is a world-wide health concern. Innovations made in tackling AMR in CF will also be applicable to solving AMR for all those with drug-resistant infections.

Dr Lucy Allen Director of Research Cystic Fibrosis Trust http://www.cysticfibrosis.org.uk

This article is from issue 14 of Health Europa. Clickhere to get your free subscription today.

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Fighting for a life unlimited with the Cystic Fibrosis Trust - Health Europa

Ozzy Osbourne: I was convinced I was dying during nightmare health year – Dothan Eagle

Ozzy Osbourne was "convinced" he was dying amid his year plagued with health setbacks.

The 'Crazy Train' hitmaker suffered a nightmare year in 2019 which saw him endure several medical issues including a fall, neck surgery, an infection in his hand, and hospitalization for the flu.

And at the start of 2020, he revealed he had been diagnosed with Parkinson's - which is a brain disorder that leads to shaking, stiffness, and difficulty with walking, balance, and coordination - for which he later had stem cell treatment to try and ease the symptoms.

Discussing his year of ill health, Ozzy said: "I'm not back to 100 percent. I'm about 75 percent there, but it's such a slow recovery. Spine surgery is bad news, man. I've been in such a bad state with pain; I'm still having a lot of pain.

"There was a point I was convinced that I was dying. I was in that much discomfort and pain and misery. I thought they were all hiding it from me. I remember saying to Sharon, 'You've gotta level with me. Is it worse than you're making it out [to be]?' She says, 'No.' ... I've dropped all the medication for pain now."

And despite his health woes, the 71-year-old rocker is itching to get back on stage as soon as the coronavirus pandemic - which has forced all concerts to be cancelled - has passed.

He added in an interview for SiriusXM: "I cannot wait [to get on stage], but I was talking to Tony Iommi the other day, and he was saying with the way it's going with this coronavirus, indoor shows will be a thing of the past."

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Ozzy Osbourne: I was convinced I was dying during nightmare health year - Dothan Eagle

Stem Cell Therapy Market Is Forecasted To Register A CAGR Growth Of XX% Between And2020 – Bulletin Line

With having published myriads of reports, PMR imparts its stalwartness to clients existing all over the globe. Our dedicated team of experts deliver reports with accurate data extracted from trusted sources. We ride the wave of digitalization facilitate clients with the changing trends in various industries, regions and consumers. As customer satisfaction is our top priority, our analysts are available 24/7 to provide tailored business solutions to the clients.

In this new business intelligence report, PMR serves a platter of market forecast, structure, potential, and socioeconomic impacts associated with the global Stem Cell Therapy market. With Porters Five Forces and DROT analyses, the research study incorporates a comprehensive evaluation of the positive and negative factors, as well as the opportunities regarding the Stem Cell Therapy market.

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Prominent players operating in the Stem Cell Therapy market players consist of the following:

Some of the major companies operating in the global stem cell therapy market are Mesoblast Ltd., Celgene Corporation, Aastrom Biosciences, Inc. and StemCells, Inc.

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Stem Cell Therapy Market Is Forecasted To Register A CAGR Growth Of XX% Between And2020 - Bulletin Line