Growing Prevalence & Recurrence Of Rheumatoid Arthritis Is Expected To Growth Of The Rheumatoid Arthritis Stem Cell Therapy Market Designer Women…

The Global Rheumatoid Arthritis Stem Cell Therapy Market is replete with new growth opportunities and expansion avenues. There has been an increase in the use of products and services falling under the ambit of Rheumatoid Arthritis Stem Cell Therapy, giving a thrust to the growth of the global Rheumatoid Arthritis Stem Cell Therapy market. The unprecedented use of these products can be attributed to the increasing paying capacity of the masses.

Furthermore, in the absence of robust or utilitarian alternatives, the demand within the global Rheumatoid Arthritis Stem Cell Therapy market is projected to reach new heights of recognition. It is worthwhile to mention that the global Rheumatoid Arthritis Stem Cell Therapy market is treading along a lucrative pathway due to favorable government legislations.

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The COVID-19 pandemic has changed narratives related to growth and expansion across several key industries. Therefore, the Rheumatoid Arthritis Stem Cell Therapy market is also battling the cons of supply chain disruptions and procurement issues. Over the course of the next quarter, market players could be investing in new technologies to recover from the shocks of the pandemic.

The global market for rheumatoid arthritis stem cell therapy is highly fragmented. Examples of some of the key players operating in the global rheumatoid arthritis stem cell therapy market include Mesoblast Ltd., Roslin Cells, Regeneus Ltd, ReNeuron Group plc, International Stem Cell Corporation, TiGenix and others.

Through the latest research report on Rheumatoid Arthritis Stem Cell Therapy market, the readers get insights on:

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Tentatively, the global rheumatoid arthritis stem cell therapy market can be segmented on the basis of treatment type, application, end-user, and geography.

Based on treatment type, the global rheumatoid arthritis stem cell therapy market can be segmented into:

Based on application, the global rheumatoid arthritis stem cell therapy market can be segmented into:

Based on the distribution channel, the global rheumatoid arthritis stem cell therapy market can be segmented into:

Based on geography, the global rheumatoid arthritis stem cell therapy market can be segmented into:

The study further identifies major manufacturing trends, technologies that will be commercialized

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Growing Prevalence & Recurrence Of Rheumatoid Arthritis Is Expected To Growth Of The Rheumatoid Arthritis Stem Cell Therapy Market Designer Women...

Catherine S. Diefenbach, MD, Talks Future of CAR T-cell Therapy Following Liso-Cel Approval in Second-Line LBCL – Cancer Network

Catherine S. Diefenbach, MD, spoke about refining understanding of CAR T-cell therapies after the approval of lisocabtagene maraleucel for patients with relapsed/refractory large B-cell lymphoma.

Lisocabtagene maraleucel (liso-cel; Breyanzi) was recently approved for the second-line treatment of patients with relapsed/refractory large B-cell lymphoma (LBCL), including diffuse large B-cell lymphoma not otherwise specified; high-grade B-cell lymphoma; primary mediastinal LBCL; and grade 3B follicular lymphoma.1 CancerNetwork spoke with Catherine S. Diefenbach, MD, director of both Hematology and Translational Research and the Clinical Lymphoma Program of Perlmutter Cancer Center at NYU Langone Health, about data from the phase 3 TRANSFORM trial (NCT03575351) that led to the approval and how the indication for this and other similar therapies may be expanded in the future with better understand regarding how to tailor the therapy.2

There are a couple of steps that are going to be important. One is to get a better idea of who benefits so we can tailor this therapy to the patients who are going to benefit the most. We need to get better at understanding the mechanisms of relapse and nonresponse to CAR T-cell therapy so that we [avoid subjecting] patients to this toxic therapy who are unlikely to benefit and/or design a next-generation CAR T-cell treatment that is going to allow more patients to have a durable response and be cured than what is currently approved. We need to get better at managing the toxicity of CAR T cells because this is still a fairly toxic therapy, and design next-generation CAR T cells that are less toxic. We need to get better about improving access so more patients can have access to CAR T cells. There are still many issues around insurance and payments for commercial CAR T cells. From a drug development, a clinical, and a public health standpoint, theres still much work that we can do to optimize this therapy.

This is an exciting time in lymphoma. We have a new therapy that was approved initially in the third line thats now moving to the second line and other exciting therapies that are nearing approval. We have more ways than ever to cure patients with lymphoma or extend the lives of people with incurable lymphoma. The challenge going forward is going to understand who benefits from which therapy and understand how to optimize response for all patients with these exciting therapies that we now have. This is an absolutely wonderful and transformative development.

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Catherine S. Diefenbach, MD, Talks Future of CAR T-cell Therapy Following Liso-Cel Approval in Second-Line LBCL - Cancer Network

Global Lupus Market is Expected to Reach USD 4.3 Billion With CAGR of 12.41% By Forecast 2027 Says Maximize Market Research (MMR) – Digital Journal

The Global Lupus Market Is Estimated To Grow To USD 4.3 Billion With A CAGR Of 12.41 Percent By 2027.

TheGlobal Lupus Markethas gained traction in the last decade, and from 2022 to 2027, it is expected to grow at a compound annual growth rate (CAGR) of 4.3 percent. Market revenue will have increased to USD 4.3 billion by the end of 2027, up from USD 1.88 billion in 2020.

Global Lupus Market Scope and Dynamics:

Due to factors such rising healthcare costs, a growing female population, rapid urbanisation, supportive government measures, rising rates of SLE disease, etc., the industry has been expanding over the past few years. Different groups and the government are doing a number of actions to educate people about SLE. Several research institutions are offering medicines and treatments to SLE patients with government funding. Government-funded trials for several novel medications are now underway. The Centers for Disease Control and Prevention (CDC) in the US frequently publish SLE disease statistics and alert the public to the diseases serious side effects, particularly in the female population.

The market is anticipated to expand quickly over the forecast period as a result of a number of current trends, including an increase in clinical trials, the use of stem cell therapy, increased public awareness, etc. One of the most promising emerging areas of medicine for the treatment of Global Lupus, particularly for patients who do not respond well to more conventional forms of treatment, may be stem cell therapy. Stem cell therapy is becoming more popular since it is a cutting-edge method for treating Global Lupus, which will boost the growth of the Global Lupus market.

One of the key elements anticipated to restrain the growth of the global Global Lupus therapeutic market over the forecast period is the negative effects of medications used to treat the disease. For instance, almost all patients receiving treatment for SLE report one or more side effects such nausea, vomiting, bone toxicity, and other symptoms, according to a paper published in the peer-reviewed, open access journal Global Lupus Science and Medicine in March 2018.

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Global Lupus Market Region Insights:

Geographically, the North America are expected to lead the Global Lupus market due to the growing need for better treatment choices, the diseases increasing prevalence, government initiatives for it, and the availability of reimbursement. In addition, the regions developed healthcare system and easy access to biologics are anticipated to support market growth.

The Global Lupus market is expected to place Europe in second place. The growth of R&D initiatives and the increased incidence of Global Lupus in the area are both credited with driving the market in this region.

China, Japan, South Korea, India, Australia, and the rest of Asia-Pacific make up the Asia-Pacific Global Lupus market. Due to the rising Global Lupus prevalence, the growing healthcare industry, and the increasing geographical development of major market participants, the Asia-Pacific region is anticipated to have the quickest growth.

Global Lupus Market Segmentation:

By Technique:

By Product:

By End-User:

By Region:

Key Players in Global Lupus Market:

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Maximize Market Research provides syndicated and custom B2B and B2C business and market research on high-growth emerging technologies, opportunities, and threats for companies in the chemical, internet of things, food and beverage, healthcare, pharmaceuticals, electronics and communications, aerospace, and defense. Maximize Market Research is best positioned to assess, estimate, and anticipate market size along with the competitive landscape of industries as businesses across the globe are battling to keep up with the pace of changing market, along with changing industrial, and technical conditions.

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Global Lupus Market is Expected to Reach USD 4.3 Billion With CAGR of 12.41% By Forecast 2027 Says Maximize Market Research (MMR) - Digital Journal

Does Chemotherapy Have Cognitive and Emotional Side Effects? – Healthline

Chemotherapy has transformed cancer care, but its benefits come with side effects. Chemo brain is the name some people give to the brain fog and fuzziness that can result from these lifesaving treatments.

Chemotherapy works by destroying fast-reproducing cancer cells. But it can kill other healthy cells along the way, including certain brain cells. The destruction of brain cells can impact your emotional state and ability to think, leading to memory and concentration problems, among other concerns.

This article will explore what types of cognitive and emotional changes you might expect from chemotherapy, what factors increase your risk for these symptoms, and what you can do to treat them.

Various emotional and cognitive symptoms can occur during chemotherapy, and they should be categorized separately. Even though they both apply to your brain and can be considered mental side effects, emotion and cognition are different.

Cognition refers broadly to the intellectual processes of absorbing, analyzing, and using information. Emotions are our feelings and responses to experiences, environments, and relationships. For example, trouble focusing is a cognitive side effect, whereas irritability is an emotional one.

Lets go over some of the most common chemotherapy side effects in both categories.

Cognitive changes are usually the most noticeable impacting daily functioning, work or school performance, and personal relationships.

Confusion or delirium is the most common of these symptoms, affecting roughly 57 to 85 percent of people undergoing chemotherapy, compared to 15 to 30 percent of people hospitalized for other medical reasons.

Cognitive changes can look different depending on the individual but commonly include:

In addition to chemo, other factors can contribute to emotional stress as part of a cancer diagnosis. The emotional impacts of chemo can look like shifts in mood, depression or anxiety. Personality changes are common, too.

These can be linked to chemotherapy treatments, the disease process, and coping with a cancer diagnosis.

Learn more about the emotional impacts of a cancer diagnosis and cancer treatment.

There are several reasons why chemotherapy can impact your mental and emotional health.

One reason is that chemo medications cross the blood-brain barrier, causing inflammation. Brain shrinkage, or a loss of neurons, has been observed as a result of both cancer and chemotherapy.

Cognitive changes can also be heightened by complications of cancer treatment or other medical conditions. Chronic pain and lack of sleep or appetite from chemotherapy treatments can have profound negative life impacts.

This can affect your energy and strength levels, making it hard to focus or regulate your emotions.

Cancers spread to the brain can also directly affect cognitive and emotional functioning. This can be separate from, or in addition to, chemo.

While chemotherapy aims to slow or stop the spread of cancer, increased changes in mental status and cognition can also be signs of metastasis, or that the cancer is spreading.

Your doctor may also want to rule out intolerances or reactions to your chemotherapy treatment.

Treating cancer requires an individualized and multidisciplinary approach. Often, a rehabilitation plan is involved in helping you cope with or heal from the effects of chemotherapy and other intensive treatments, including any surgeries.

Your doctor may want to adjust your chemotherapy regimen depending on your side effects.

Cognitive rehabilitation is sometimes included in a chemotherapy plan and offers activities or exercises to help keep your mind sharp and focused during treatment.

The American Cancer Society suggests that exercise and meditation can go a long way in reducing the mental toll of chemotherapy and other cancer treatments.

Also, talk therapy, including cognitive behavioral therapy (CBT), may help you process the complex emotions arising from a cancer diagnosis and treatment.

Talk therapies can help you develop coping techniques that may help you manage fatigue, confusion, and any depression or anxiety you are experiencing due to chemotherapy.

There are particular cancer and chemotherapy medications that can increase the chances of confusion, delirium, and other cognitive changes in some people. Your doctor should review any risks of a potential treatment option with you when designing your chemo regimen.

Consider coming to your appointment prepared with questions about what risk of physical and mental impacts chemo may cause. Ensure your doctor knows all medications you are currently taking to avoid adverse reactions.

If you choose to move forward with treatment, your doctor may be able to help you find ways to preserve your thinking abilities should chemo affect them, or at the very least learn to cope with the changes.

There are certain risk factors that may increase your chance of experiencing mental side effects during chemotherapy.

Besides taking specific medications or having brain cancer, this can include having:

Chemotherapy can effectively manage cancer and bring about remission. But the medications for chemotherapy are strong and highly toxic to other cells and systems in your body. This treatment can cause unpleasant physical, mental, and emotional symptoms.

The physical effects of chemotherapy like nausea and hair loss are well-known, but substantial mental and cognitive changes can also happen with this therapy. Chemo brain refers to the fatigue, confusion, and overall brain fog some people experience.

Talk with your doctor about the specific risks versus benefits for your type of cancer, stage, and prescribed chemotherapy regimen. Your medical team should be able to help you with therapies and strategies that can help you cope with the emotional and cognitive toll of cancer and chemotherapy.

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Does Chemotherapy Have Cognitive and Emotional Side Effects? - Healthline

Academic-industry partnership aims to lower the cost of cultivated meat – University of Toronto

When the University of TorontosMichael Gartongot a call from Myo Palate a company that is producing meat without raising whole animals he knew it was the opportunity hed been waiting for.

My research has always been focused on health care and medical applications, says Garton, an assistant professor in the Institute of Biomedical Engineering in the Faculty of Applied Science & Engineering.

But environmental issues are something I really care about something we all care about. Given the impact that agriculture has on the environment, I knew this would be a great way to make a difference.

Myo Palate is looking tap the synthetic biology expertise of Garton and his team in an effort to reduce the cost of growing muscle cells. The collaborationis funded by a grant provided jointly by Genome Ontario and the Canadian Food Innovation Network.

This is an exciting opportunity to collaborate with Dr. Garton and utilize cutting-edge synthetic biology techniques to reduce the cost of growing muscle cells, says Frank Yu, co-founder of Myo Palate.

While our initial products will not contain genetic modifications, we think that this will be a game changer for the future.

Gartonscurrent medical researchinvolvesdesigning customized stem cells, derived from a patients own tissues, that could be used to treat certain diseases or conditions.

For example, one challenge we are interested in is neurological diseasessuch as multiple sclerosis or ALS, which are caused or amplified by chronic inflammation of nerve tissue, says Garton.

We can take stem cells from a patient and program them to specifically detect chronic inflammation and to release anti-inflammatory molecules in response. We could then re-implant those cells back into the body.

Because the anti-inflammatory molecules are released only where and when they are needed, this approach known asex vivogene therapy could reduce the side effects associated with treatment via traditional drugs.

Using this knowledge to create cultivated meat that is, animal cells grown outside a living animal may not seem like an intuitive leap to make, but Garton says that there are plenty of parallels.

In our work, we face the challenge of getting our stem cells to grow and differentiate into the types of tissues we want to make, he says.

Producers of cultivated meat will be doing much of the same thing. And because their cells will be consumed as food, rather than implanted into a patient, there are fewer obstacles in the overall process, which in a way makes it slightly easier.

But the challenges of creating cultivated meat go well beyond whether or not it is technically possible economics are also critically important. Cultivated meat is not yet cost-competitive with raising whole animals, which is one of the major factors limiting its widespread adoption.

Unless we can get the cost down, its just not going to fly, says Garton. What were hoping is that our expertise in synthetic biology can reduce or even remove the need for some of the more costly inputs.

One example is growth factors, which are specialized biochemicals that signal what kind of environment a given cell is growing in. Their presence or absence determines what type of tissue a stem cell will grow into: for example, skin, nerves or muscle.

In the case of cultivated meat, the goal is typically to produce myocytes, or large muscle cells. While growth factors that result in this type of tissue can be readily purchased, their relatively high cost is a major hurdle to producing cultivated meat at a competitive price.

Garton and his team hope that their research can result in stem cells that require lower amounts of these growth factors, or even none at all.

Were testing lots of different ways of approaching this challenge, and were also automating the process so we can do it in a high-throughput way, says Garton.

Were developing machine learning methods that can sort through the data to find out whats working and whats not, and what will most likely be successful in the next iteration.

Garton says he is excited about the opportunity to make an impact in a fast-growing field.

Its going to be a very long time before we have a stem cell that automatically grows into a real muscle in the lab with minimal inputs, he says.But in terms of putting the foundational pieces and core building blocks in place to achieve that, I think were going to be able to deliver some real insights relatively quickly.

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Academic-industry partnership aims to lower the cost of cultivated meat - University of Toronto

Crowdfunder launched to pay for life-changing treatment abroad for Brora mum battling MS issues: ‘If you can help me get a chance of a new life, I…

Residents in Sutherland are being urged to support a crowdfunder to meet the cost of private treatment abroad for a local woman diagnosed with a potentially life-threatening illness.

A fundraising drive has been launched in the hope of sending 41-year-old Kirsteen Mackay, a Durness native now living in Brora, to Mexico for treatment which she is unable to access on the NHS.

Within hours of the crowdfunder going live this week, it had reached 20 per cent of its 57,000 target.

On her social media page, Ms Mackay, who is experiencing a complication linked to multiple sclerosis, said: The last few years have been a struggle for me and this last year has been the worst as I have had failed treatments with awful side effects.

I just want to thank those who have helped me and continue to do so, as I would not have made it this far without you.

I know money is tight for everyone, but if you can help me get a chance of a new life, I will be forever grateful.

The caring, generous and fun-loving mum, who has a six-year-old son Ruaraidh and who runs Kirsteens Kollection, a decor service for all occasions, was diagnosed in 2018 with relapsing-remitting multiple sclerosis (RRMS).

Jade McAlea, who set up the crowdfunder said: Kirsteens RRMS is very active and medication is crucial to keeping symptoms or the progression of symptoms under control.

But Ms Mackay was recently dealt a devastating blow when she was told she had tested positive for John Cunningham virus (JC).

The virus is common and usually harmless - in most people it is dormant and does not directly cause health problems. However it can trigger a life-threatening condition called multifocal leukoencephalopathy (PML).

A few of the medications that doctors use to treat MS can reactivate the dormant virus and lead to PML.

This means that treatment for RRMS has been reduced to one option, which can be used for a year, said Ms McAlea. Unfortunately this treatment is also linked to patients being in a high-risk category for developing PML.

The NHS has been wonderful so far in supporting Kirsteen with effective treatment for her RRMS diagnosis, but with this most recent development of JC, the treatment option and timeline is simply time she does not have to spare due to the risk of symptoms exacerbating..

Her most hopeful outcome is to undergo treatment which is available privately in Mexico, but the cost of this treatment means it is an option out of reach. That is where we believe people can make the lifesaving difference.

The procedure Ms Mackay hopes to undergo at Clinica Ruiz in Puebla, is Haematopoietic Stem Cell Transplantation (HSTC), an intense chemotherapy treatment where the patients own stem cells are used to reboot their immune system.

Ms Mackay is not eligible for HSTC on the NHS because she is not a wheelchair user, her family said. The treatment is not available privately in Scotland and there are long waiting lists to have it privately in England.

Ms McAlea continued: We have every faith in our community that we can all come together at such a devastating time for Kirsteen and her family.

No help is too big or small and with all your support, we can provide Kirsteen with the hope of a healthy, happy future.

Click here to donate.

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Crowdfunder launched to pay for life-changing treatment abroad for Brora mum battling MS issues: 'If you can help me get a chance of a new life, I...

Updates in the Treatment of HER2+ mBC from ASCO 2022 – OncLive

Vijayakrishna Gadi, MD, PhD: I would say that, in all of this HER2 disease, sadly if you have HER2-postivie breast cancer, although weve done a tremendous job extending the lives of those patients, ultimately the majority of those patients still die. We cant rest on our laurels, and weve got to keep innovating in this area. There are many, many new molecules and entities that are being considered, and Im excited to test those. Weve heard about a number of them at this 2022 ASCO [American Society of Clinical Oncology Annual] Meeting, and obviously in its early days, and we hope that those will come in.

The other emphasis or way to look at it is, now that we have all these tools, what can we put together in a safe manner that could still be effective for our patients? Ill highlight a few trials in this regard. One is looking at combining T-DM1 [trastuzumab emtansine] with tucatinib; the so-called HER2CLIMB-02 study [NCT03975647]. Thats a trial thats ongoing. We hope that itll accrue quickly, and then well have answers, but heres a generally well-tolerated antibody-drug conjugate being combined with tucatinib, which has the CNS [central nervous system]-penetrating ability. You can see where Im going with this with covering our bases above the neck but also below the neck. That could be one option. If its successful, its a randomized phase 3 trial, so it could be a new standard of care depending on what we learn from that.

Theres a DESTINY-Breast trial looking in a phase 2 setting at patients with CNS metastases and the combination of tucatinib. That study is still looking at safety initially, and then hopefully we will be able to expand out to efficacy cohorts. Itll be a smaller study, but it may give us a signal that then we can formally test in a larger randomized control trial. Thats another option. Then lastly, [we are] looking at combinations with drugs like tucatinib and conventional things like chemotherapy: trastuzumab and pertuzumab. Although its not from the metastatic setting, when we try to do that in the I-SPY2 trial [NCT01042379] in the preoperative setting, that was actually too toxic. It was effective, but it was too toxic and should not be pursued at this time, so weve got to go back to the drawing board on that one. Its not all wins. We are going to look at these combinations, but certainly, with the tools we have, we may be able to push the needle quite a bit by just combining them. The adage is, If you cant beat them, join them, so thats what were seeing in this space.

At2022 ASCO, a standing ovation talk claimed there is a new standard of care, which was the DESTINY-Breast04 trial [NCT0373402].. To refresh everybodys memory just in case, DESTINY-Breast04 was a trial that looked at patients with HER2-low diseaseIm going to talk about the definition of HER2-low in a minuteand using trastuzumab deruxtecan vs physicians choice chemotherapy options. In that trial, [there was a] running away nice separation of the curves for this HER2-low population favoring the trastuzumab deruxtecan. Fortunately, [there were] not a lot of new emergent [adverse] effects or toxicities that make us take pause in this. [They were] very familiar in terms of toxicities and were in many cases favorable compared to chemotherapy. [It is] very easy to say, Yeah, this could be a new standard of care.

Now Im Monday-morning quarterbacking on this molecule in this study. First off, what is HER2-low? We know that some cancers, when they express HER2 strongly, we call it HER2+. Those are cancers where the driver is the HER2 gene. Those are cancers that we can target with all our conventional therapies that weve had access to: trastuzumab, pertuzumab, tucatinib, neratinib, and all these molecules become relevant. For these, HER2, IHC [immunohistochemistry] 2-positive and below, this is not a driver. Its a target of convenience. The expression is necessary to get the antibody-drug conjugate to the location, internalize the chemotherapy, and then kill the cancer cell. Fortunately, with trastuzumab deruxtecan, you have this wonderful thing called bystander killing. The chemotherapy leaks out and kills the neighboring cells as well. Even if you have low or heterogeneous expression of the HER2 target as a target of convenience, its localizing the chemotherapy to where we need it to be, and that chemotherapy is very potent. That has now formally been tested in a randomized controlled [phase] 3 trial and that hypothesis is true. This is an effective molecule for that disease space.

As we try to integrate this, a lot of these patients have hormone receptorpositive disease. I suspect were going to continue to tackle that because those therapies are well tolerated compared to chemotherapies and even antibody-drug conjugates. Once those stop working for our patients, its very easy to think how well be reaching for trastuzumab deruxtecan for those patients. Within that trial, they also studied what we call triple-negative disease thats HER2-low. For those patients, there are now a couple of options. We have sacituzumab govitecan, which is formally evaluated in a robust dataset and [has been] shown to benefit those patients, but we also have this very active molecule, trastuzumab deruxtecan. If you notice how Im saying these words, govitecan [and] deruxtecan, they end in the same terminal 5 letters. These are all Topo1 inhibitors, so there may be cross-resistance. Our ability to use these drugs one after the other isnt assumed. We have to test that formally to see if thats even possible. I think, in the triple-negative space, [its] a little murky. For those HER2-low [cases], you have a couple of options, and for those that dont make HER2 at any level, the so-called HER2-0 [cases], I think sacituzumab govitecan might be the choice for those patients.

Thank you very much for listening to my ramblings about HER2-positive metastatic breast cancer. Its a rapidly changing field. If you took boards just a few years ago, youve go5t to know a lot going forward to make sure you do well on the boards in the future. Fortunately, for our patients, this innovation is really making an impact for them, so thank you to the patients whove also participated on these studies to help the patients coming down the pipe.

Transcript has been edited for clarity.

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Updates in the Treatment of HER2+ mBC from ASCO 2022 - OncLive

Global Adrenoleukodystrophy Treatment Market Trends, Growth, Opportunities and Forecast to 2029 Designer Women – Designer Women

Theadrenoleukodystrophy treatment marketis expected to witness market growth at a rate of 10.25% in the forecast period of 2022 to 2029. Data Bridge Market Research report on adrenoleukodystrophy treatment market provides analysis and insights regarding the various factors expected to be prevalent throughout the forecast period while providing their impacts on the markets growth. The rise in the prevalence of chronic diseases globally is escalating the growth of adrenoleukodystrophy treatment market.

Adrenoleukodystrophy refers to a rare genetic condition that causes the buildup of long chain fatty acids (VLCFAs) in the brain. ALD is led by a mutation in the ABCD1 gene on the X chromosome. The three types of adrenoleukodystrophy including Adrenomyelopathy, Childhood cerebral ALD and Addisons disease. Childhood cerebral ALD is known to progress rapidly in children between the ages of 3 and 10.

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This adrenoleukodystrophy treatment market report provides details of new recent developments, trade regulations, import export analysis, production analysis, value chain optimization, market share, impact of domestic and localized market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, geographic expansions, technological innovations in the market. To gain more info adrenoleukodystrophy treatment market contact Data Bridge Market Research for anAnalyst Brief, our team will help you take an informed market decision to achieve market growth.

Global Adrenoleukodystrophy Treatment Market Scope and Market Size

The adrenoleukodystrophy treatment market is segmented on the basis of types, treatment, route of administration, end-users and distribution channel. The growth among segments helps you analyze niche pockets of growth and strategies to approach the market and determine your core application areas and the difference in your target markets.

To get more insights into the market analysis, browse the research report summary @- https://www.databridgemarketresearch.com/reports/global-adrenoleukodystrophy-treatment-market

Adrenoleukodystrophy Treatment Market Country Level Analysis

The adrenoleukodystrophy treatment market is analyzed and market size information is provided by country, types, treatment, route of administration, end-users and distribution channel as referenced above. The countries covered in the global adrenoleukodystrophy treatment market report are U.S., Canada and Mexico in North America, Peru, Brazil, Argentina and Rest of South America as part of South America, Germany, Italy, U.K., France, Spain, Netherlands, Belgium, Switzerland, Turkey, Russia, Hungary, Lithuania, Austria, Ireland, Norway, Poland, Rest of Europe in Europe, Japan, China, India, South Korea, Australia, Singapore, Malaysia, Thailand, Indonesia, Philippines, Vietnam, Rest of Asia-Pacific (APAC) in Asia-Pacific (APAC), South Africa, Saudi Arabia, U.A.E, Kuwait, Israel, Egypt, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA).

North America dominates the adrenoleukodystrophy treatment market due to the well-established healthcare infrastructure and presence of key market players within the region. Asia-Pacific is expected to witness high growth during the forecast period of 2022 to 2029 because of the rise in awareness about rare diseases in the region.

The country section of the report also provides individual market impacting factors and changes in regulation in the market domestically that impacts the current and future trends of the market. Data points such as new sales, replacement sales, country demographics, disease epidemiology and import-export tariffs are some of the major pointers used to forecast the market scenario for individual countries. Also, presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, impact of sales channels are considered while providing forecast analysis of the country data.

Competitive Landscape and Adrenoleukodystrophy Treatment Market Share Analysis

The adrenoleukodystrophy treatment market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies focus related adrenoleukodystrophy treatment market.

Some of the major players operating in the adrenoleukodystrophy treatment market report are bluebird bio, Inc., Orpheris, Inc., MedDay Pharmaceuticals, MINORYX THERAPEUTICS SL, Pfizer Inc., Amgen Inc., AstraZeneca, Abbott, agtc, ReceptoPharm, Inc., The Myelin Project, SOM Biotech SL, Viking Therapeutics, Nutra Pharma Corporation, Genetix Biotech Asia Pvt. Ltd., Magenta Therapeutics, NeuroVia, Inc., Novartis AG, CELGENE CORPORATION, Jazz Pharmaceuticals, Inc., and Sanofi among others.

Browse Complete TOC athttps://www.databridgemarketresearch.com/toc/?dbmr=global-adrenoleukodystrophy-treatment-market

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Global Adrenoleukodystrophy Treatment Market Trends, Growth, Opportunities and Forecast to 2029 Designer Women - Designer Women

SCUBE3 as a treatment for hair loss and alopecia – Open Access Government

Researchers from the University of California have discovered that a signalling molecule called SCUBE3 potently stimulates hair growth and may offer therapeutic treatment for androgenetic alopecia, a common form of hair loss in both women and men.

The precise mechanism uses dermal papilla cells, which play a pivotal role in controlling hair growth.

These cells specialise in signal-making fibroblasts at the bottom of each hair follicle, which promotes new hair growth.

The production of activating molecules by the dermal papilla cells is critical for efficient hair growth in mice and humans. In people with androgenetic alopecia, dermal papilla cells malfunction, greatly reducing the normally abundant activating molecules.

The genetic basis of the activating molecules involved has been previously poorly understood, so the researchers used a mouse model with hyperactivated dermal papilla cells and excessive hair to facilitate more discoveries about hair growth regulation.

After the researchers microinjected SCUBE3 into mouse skin, where human scalp follicles had been transplanted, new growth began in both the dormant human and surrounding mouse follicles.

Maksim Plikus, Ph.D., UCI professor of developmental & cell biology, said: At different times during the hair follicle life cycle, the very same dermal papilla cells can send signals that either keep follicles dormant or trigger new hair growth.

We revealed that the SCUBE3 signalling molecule, which dermal papilla cells produce naturally, is the messenger used to tell the neighbouring hair stem cells to start dividing, which heralds the onset of new hair growth.

Co-first author Yingzi Liu, a UCI postdoctoral researcher in developmental & cell biology, added: Studying this mouse model permitted us to identify SCUBE3 as the previously unknown signalling molecule that can drive excessive hair growth.

Currently, there are two medications on the market, finasteride and minoxidil, which have been approved by the Food and Drug Administration for androgenetic alopecia in the USA.

Finasteride is only approved for use in men, but both drugs are not universally effective and need to be taken daily to maintain their clinical effect. SCUBE3 could be an alternative to these medications in the future.

co-first author Christian Guerrero-Juarez, a UCI postdoctoral researcher in mathematics, said: These experiments provide proof-of-principle data that SCUBE3 or derived molecules can be a promising therapeutic for hair loss.

Plikus finalised: There is a strong need for new, effective hair loss medicines, and naturally occurring compounds that are normally used by the dermal papilla cells present ideal next-generation candidates for treatment. Our test in the human hair transplant model validates the preclinical potential of SCUBE3.

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SCUBE3 as a treatment for hair loss and alopecia - Open Access Government

Tevogen Bio Appoints Acclaimed Oncologist and Immunotherapy Expert Neal Flomenberg, M.D. as Chief Scientific Officer and Global Head of R&D – Yahoo…

WARREN, N.J., July 07, 2022--(BUSINESS WIRE)--Tevogen Bio, a late stage clinical biotechnology company specializing in developing cell and gene therapies in oncology, neurology, and virology, today announced the appointment of preeminent oncologist Neal Flomenberg, M.D. as Chief Scientific Officer (CSO) and Global Head of Research and Development. Dr. Flomenberg will lead the companys diverse and rapidly advancing research and development initiatives of its highly adaptable precision T cell product pipeline in oncology, neurology, and virology.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220707005531/en/

Acclaimed oncologist and immunotherapy expert, Neal Flomenberg, M.D. joins Tevogen Bio as Chief Scientific Officer and Global Head of R&D (Photo: Business Wire)

Most recently, Dr. Flomenberg served as Professor and Chairman of the Department of Medical Oncology and Deputy Director of Sidney Kimmel Cancer Center of Thomas Jefferson University & Hospital. Under his leadership, Jeffersons Department of Medical Oncology more than tripled in size, established a nationally recognized senior adult oncology program as well as an embedded Supportive Medicine and Survivorship Program. At Jefferson, Dr. Flomenberg also served as Director of the Hematologic Malignancies, Blood and Marrow Transplantation (BMT) Program.

Throughout his more than forty-year career, Dr. Flomenberg has maintained a longstanding interest in the immunogenetics and immunology of stem cell transplantation, with the goal of making transplantation safer and more widely available. As Chairman of Tevogens Scientific Advisory Board, he helped advance Tevogens lead investigational product, TVGN-489, through proof-of-concept clinical trial for treatment of high-risk COVID-19 patients. Trial enrollment is currently nearing completion.

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In his new capacity at Tevogen, Dr. Flomenberg will serve as member of the executive team and lead companys ambitious R&D initiatives, allowing for further advancement of its next generation precision T cell technology platforms. Dr. Flomenberg and his leadership team will operate out of Tevogens R&D Center located in Philadelphias Wanamaker building.

"There is no better person than Neal to lead the advancement of Tevogens highly promising genetically unmodified T cell technology platforms, which we believe will pave the way for the next era of personalized T cell therapeutics for large patient populations through convenience and affordability for the very first time," said Tevogen CEO Ryan Saadi, M.D., M.P.H. "A lifelong student of science, Neals compassionate nature, brilliant mind, and unwavering passion to innovate leading-edge medicines for the good of humanity are just a few of the characteristics that make him the ideal leader to realize the fullest potential of our R&D initiatives."

"I am thrilled to serve in this new role at Tevogen, a truly patient-centric company designed to achieve commercial success through its advanced science and efficient business model which ensure affordability. I have dedicated my career to increasing our understanding of blood cancers and the infections which plague these and other patient groups as well as the cellular immunologic approaches which might be used to address these problems," said Dr. Flomenberg. "Tevogens proprietary approach allows cellular immunotherapeutics to be developed with unprecedented specificity and precision while remaining affordable and broadly applicable. Applications range from acute viral infections such as COVID-19, to longer term consequences of infections such as Long-COVID and Multiple Sclerosis, to viral-induced and non-viral induced cancers," he added.

Dr. Flomenberg has been the recipient of numerous awards including: The Simon Gratz Award for Research Most Likely to influence Patient Care (2003), The Leukemia Lymphoma Society Contributions to Mankind Award (2006), The Pennsylvania State University Outstanding Science Alumnus Award (2006), Inaugural recipient of the Philadelphia Chapter of the Leukemia Lymphoma Societys Lifetime Achievement Award (2018), Thomas Jefferson Universitys Alumnus of the Year Award (2019), and Jeffersons Deans Lifetime Distinguished Service Award (2022).He received a Bachelor of Science degree from Penn State University and earned a Doctor of Medicine degree from Jefferson Medical College.

About Tevogens Next Generation Precision T Cell Platform

Tevogens next generation precision T cell platform is designed to provide increased specificity to eliminate malignant and virally infected cells, while allowing healthy cells to remain intact. Multiple targets are selected in advance with the goal of overcoming mutational capacity of cancer cells and viruses.

Tevogen is investigating its technologys potential to overcome the primary barriers to the broad application of personalized T cell therapies: potency, purity, production-at-scale, and patient-pairing, without the limitations of current approaches. Tevogens goal is to open the vast and unprecedented potential of developing personalized immunotherapies for large patient populations impacted by common cancers and viral infections.

The companys lead product, TVGN-489, is currently in clinical trial for high-risk COVID-19 patients at Jefferson University Hospitals in Philadelphia. TVGN-489 is a highly purified, genetically unmodified, off-the-shelf, allogeneic SARS-CoV-2-specific cytotoxic CD8+ T lymphocyte (CTL) product designed to detect targets spread across the entire viral genome.

Tevogen recently announced the initiation of the fourth and final dose level of its investigational T cell therapy for high-risk COVID-19 patients in the proof of concept clinical trial of TVGN-489. No dose limiting toxicities or treatment-related adverse events, including Cytokine Release Syndrome (CRS), have been observed to date in any of the dose cohorts.

About Tevogen Bio

Tevogen Bio is driven by a team of distinguished scientists and highly experienced biopharmaceutical leaders who have successfully developed and commercialized multiple franchises. Tevogens leadership believes that accessible personalized immunotherapies are the next frontier of medicine, and that disruptive business models are required to sustain medical innovation in the post-pandemic world.

Forward Looking Statements

This press release contains certain forward-looking statements relating to Tevogen Bio Inc (the "Company") and its business. These statements are based on managements current expectations and beliefs as of the date of this release and are subject to a number of factors which involve known and unknown risks, delays, uncertainties and other factors not under the Companys control that may cause actual results, performance or achievements to be materially different from the results, performance or other expectations implied by these forward-looking statements. Forward-looking statements can sometimes be identified by terminology such as "may," "will," "should," "intend," "expect," "believe," "potential," "possible," or their negatives or comparable terminology, as well as other words and expressions referencing future events, conditions, or circumstances. In any forward-looking statement in which the Company expresses an expectation or belief as to future results, there can be no assurance that the statement or expectation or belief will be achieved. Various factors may cause differences between the Companys expectations and actual results, including, among others: the Companys limited operating history; uncertainties inherent in the execution, cost and completion of preclinical studies and clinical trials; risks related to regulatory review and approval and commercial development; risks associated with intellectual property protection; and risks related to matters that could affect the Companys future financial results, including the commercial potential, sales, and pricing of the Companys products. Except as required by law, the Company undertakes no obligation to update the forward-looking statements or any of the information in this release, or provide additional information, and expressly disclaims any and all liability and makes no representations or warranties in connection herewith or with respect to any omissions herefrom.

View source version on businesswire.com: https://www.businesswire.com/news/home/20220707005531/en/

Contacts

Media: Katelyn Joyce Corporate Communications Lead T: 1 877 TEVOGEN, Ext 709 Katelyn.joyce@tevogen.com

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Tevogen Bio Appoints Acclaimed Oncologist and Immunotherapy Expert Neal Flomenberg, M.D. as Chief Scientific Officer and Global Head of R&D - Yahoo...