The American Academy of Stem Cell Physicians Adds Three Workshops to the June 17-19, 2022 Conference – StreetInsider.com

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MIAMI, May 24, 2022 (GLOBE NEWSWIRE) -- The American Academy of Stem Cell Physicians has added three new workshops to its long-awaited conference this June 17-19, 2022. The hands-on workshops will be led by industry leaders in regenerative medicine. The workshops will be on intradiscal injections, bone marrow aspiration and muscular-skeleton ultrasound techniques. Beyond these educational workshops, The American Academy of Stem Cell Physicians is also presenting a great lineup of acclaimed regenerative medicine leaders discussing what's new in regenerative medicine. This conference is not to be missed.

Dr. Joseph Purita, a pioneer in the use of regenerative cell and PRP therapy for orthopedic conditions, graduated from Georgetown University Medical School and served his surgical internship at the University of Florida Medical Center. Dr. Purita is an instructor and proctor of surgeons in the use of lasers in arthroscopic and orthopedic surgery at a variety of area hospitals. At The American Academy of Stem Cell Physicians, Dr. Purita will lead a workshop on bone marrow aspiration.

Dr. Warren J. Bleiweiss, a guest speaker for AASCP and the American Academy of Stem Cell Physicians' first Fellow graduate, will provide a talk on his innovative regenerative medicine treatments. Dr. Bleiweiss is a national leader in the use of ozone injection treatments for herniated discs, joint and muscle pain, and injuries. He pioneered the outpatient oxygen-ozone disc injection procedure in the United States and remains a leading expert in North America in treating disc herniations with ozone injections without surgery or medication.

The American Academy of Stem Cell Physicians invites you to learn more about Intra Discal PRP injections. Dr. Bleiweiss said, "I am looking forward to discussing all the new advancements in the Regenerative field for 2022 at this year's workshop."

Dr. Kim attended college at Cornell University in NY and received his medical degree from RutgersNew Jersey Medical School. The President of The American Academy of Stem Cell Physicians, Dr. Sunny Kim is also thefounder and President of Progressive Rehabilitation Medicine, whose mission is offering advanced non-surgical pain management solutions. Dr. Kim's workshop is on advanced muscular-skeletal ultrasound diagnostic and injection techniques.

The spokesman for the AASCP, Dr. AJFarshchian,said earlier: "The American Academy of Stem Cell Physicians is a group of physicians, scientists and researchers who collectively represent the most authoritativenon-federal group advocating for guidelines and education on stem cell therapy and regenerative medicine. The AASCP is involved directly with other authorities within the field and seeks only to bring knowledge and awareness for the ever-growing regenerative medicine industry." Dr. Farshchian, a pioneer in regenerative medicine, will offer a workshop on neurogenesis.

AASCP is hosting their medical conference in Miami on June 17-19, 2022. The conference is taking place at the downtown MiamiHyatt Regency, located at 400 SE 2nd Ave., Miami, FL 33131.Becauseof limited seating, we encourage everyone to please RSVP atwww.aascp.net andto register. Registrations are going fast, please register today.

The American Academy of Stem Cell Physicians (AASCP) is an organization created to advance research and the development of therapeutics in regenerative medicine, including diagnosis, treatmentand prevention of disease related to or occurring within the human body. Secondarily, the AASCP aims to serve as an educational resource for physicians, scientistsand the public in diseases that can be caused by physiological dysfunction that areameliorableto medical treatment.

For further information, please contact WilsonDemenessez or Luana Ingrid at AASCP 305-891-4686, and you can also visit us at http://www.aascp.net.

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The American Academy of Stem Cell Physicians Adds Three Workshops to the June 17-19, 2022 Conference - StreetInsider.com

Characteristics of anti-CLL1 based CAR-T therapy for children with relapsed or refractory acute myeloid leukemia: the multi-center efficacy and safety…

Abstract: C-type lectin like molecule-1 (CLL1) is preferentially expressed on acute myeloid leukemia (AML) stem cells and AML blasts, and can be considered as AML-associated antigen. Anti-CLL1-based CAR-T cells exhibited effective tumor killing capacity in vitro and in AML-bearing mouse model. In this report, eight children with relapsed or refractory AML (R/R-AML) were recruited for a phase 1/2 clinical trial of autologous anti-CLL1 CAR-T cell immunotherapy. The objectives of this clinical trial were to evaluate the safety and the anti-AML responses after CLL1-CAR-T cell treatment, with long-term prognosis within those patients who did not receive allogeneic hematopoietic stem cells transplantation (allo-HSCT) as an additional aim. These R/R-AML patients received one dose of autologous CLL1-CAR-T cells after lymphodepletion conditioning. Grade 34 hematologic adverse events were observed post CAR-T cell infusion. Meanwhile, grade 12 cytokine release syndrome (CRS) was observed but without any lethal events. 4 out of 8 AML patients achieved incomplete remission (CRi) and minimal residual disease (MRD) negativity, 2 patients with CRi but MRD positivity, and 2 patients with decreased AML burden and CLL1 positive AML blast clearance. These results suggested that anti-CLL1-based CAR-T cell immunotherapy can be considered as a well-tolerated and effective option for treating children with R/R-AML.

See the article here:
Characteristics of anti-CLL1 based CAR-T therapy for children with relapsed or refractory acute myeloid leukemia: the multi-center efficacy and safety...

InnoCare Announces Approval to Conduct a Phase II Clinical Trial of Tafasitamab in Combination with Lenalidomide in China – Business Wire

BEIJING--(BUSINESS WIRE)--InnoCare Pharma (HKEX: 09969) announced today that it has received approval to conduct a single-arm, open-label, multicenter phase II clinical trial evaluating the safety and efficacy of tafasitamab in combination with lenalidomide by Chinas National Medical Products Administration (NMPA) for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who are not eligible for autologous stem cell transplantation (ASCT).

Tafasitamab is a humanized Fc-modified cytolytic CD19 targeting monoclonal antibody, which is conditionally approved by both the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) in combination with lenalidomide for the treatment of adult patients with relapsed or refractory DLBCL who are not eligible for ASCT. Tafasitimab is not approved by the NMPA for any indication.

Dr. Jasmine Cui, Co-founder, Chairwoman and CEO of InnoCare, said, We will make every effort to accelerate the clinical development of tafasitamab in combination with lenalidomide to help address the unmet needs of DLBCL patients in China.

Tafasitamab (Monjuvi) is co-commercialized by Incyte and MorphoSys in the United States and by Incyte under the brand name Minjuvi in the EU. As part of its agreement with MorphoSys, Incyte received exclusive commercialization rights for tafasitamab outside the United States, and in August 2021, Incyte entered into a collaboration and license agreement with InnoCare for the development and exclusive commercialization of tafasitamab in hematology and oncology in Greater China.

DLBCL is the most common type of non-Hodgkin lymphoma (NHL), and its incidence accounts for 31% to 34% of NHL globallyi. In China, DLBCL accounts for 45.8% of all NHLsi.

About Tafasitamab

Tafasitamab is a humanized monoclonal antibody targeting CD19.

In 2010, MorphoSys licensed exclusive worldwide rights to develop and commercialize tafasitamab from Xencor, Inc.

Tafasitamab incorporates an XmAb engineered Fc domain, which mediates B-cell lysis through apoptosis and immune effector mechanism including Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Antibody-Dependent Cellular Phagocytosis (ADCP).

In the United States, Monjuvi (tafasitamab-cxix) is approved by the U.S. Food and Drug Administration in combination with lenalidomide for the treatment of adult patients with relapsed or refractory DLBCL not otherwise specified, including DLBCL arising from low grade lymphoma, and who are not eligible for ASCT. This indication is approved under accelerated approval based on overall response rate. Full approval for this indication may be contingent upon results in a confirmatory trial(s).

In Europe, Minjuvi (tafasitamab) received conditional approval, in combination with lenalidomide, followed by Minjuvi monotherapy, for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who are not eligible for autologous stem cell transplant (ASCT).

Tafasitamab is being clinically investigated as a therapeutic option in B-cell malignancies in several ongoing combination trials.

Tafasitamab is not approved for use in China except for in the Boao Lecheng International Medical Tourism Pilot Zone through an early access program.

Minjuvi and Monjuvi are registered trademarks of MorphoSys AG. Tafasitamab is co-marketed by Incyte and MorphoSys under the brand name Monjuvi in the U.S. and marketed by Incyte under the brand name Minjuvi in the EU. As part of its agreement with MorphoSys, Incyte received exclusive commercialization rights for tafasitamab outside the United States, and in August 2021, Incyte entered into a collaboration and license agreement with InnoCare for the development and exclusive commercialization of tafasitamab in hematology and oncology in Greater China.

XmAb is a registered trademark of Xencor, Inc.

About InnoCare

InnoCare is a commercial stage biopharmaceutical company committed to discovering, developing, and commercializing first-in-class and/or best-in-class drugs for the treatment of cancer and autoimmune diseases. We strategically focus on lymphoma, solid tumors, and autoimmune diseases with high unmet medical needs in China and worldwide. InnoCare has branches in Beijing, Nanjing, Shanghai, Guangzhou, Hong Kong, and United States.

InnoCare Forward-looking Statements

This report contains the disclosure of some forward-looking statements. Except for statements of facts, all other statements can be regarded as forward-looking statements, that is, about our or our management's intentions, plans, beliefs, or expectations that will or may occur in the future. Such statements are assumptions and estimates made by our management based on its experience and knowledge of historical trends, current conditions, expected future development and other related factors. This forward-looking statement does not guarantee future performance, and actual results, development and business decisions may not match the expectations of the forward-looking statement. Our forward-looking statements are also subject to a large number of risks and uncertainties, which may affect our short-term and long-term performance.

i Hematology Branch of Chinese Medical Association2013

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InnoCare Announces Approval to Conduct a Phase II Clinical Trial of Tafasitamab in Combination with Lenalidomide in China - Business Wire

Stem Cell Therapy Market 2022 Growing with Major Eminent Key Players Anterogen Co., Ltd., MEDIPOST Co., Ltd., Osiris Therapeutics, Inc. and Pharmicell…

The global Fluoropolymer Films Market study intends to deliver a thorough understanding of the market situation in the present, past along with future projections and market estimations framed based on evidential data provided by marketers. This set of data includes the market size and volume of the Global Fluoropolymer Films Market with respect to current market dynamics and the anticipated business size during the forecast graphically represented. Essential data regarding the cost-structure, supply chain and revenue is portrayed as a whole and with granular classification categorizing the Global Fluoropolymer Films Market into business level, industrial level and regional level defining the business growth of the Global Fluoropolymer Films Market in future.

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Leading players of Fluoropolymer Films Market including:

The Chemours Company, 3M, Saint-Gobain, Nitto Denko, Honeywell International, Daikin, Rogers Corporation, DUNMORE, AGC Chemicals, Guarniflon, Textiles Coated International

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Polytetrafluoroethylene (PTFE) films Polyvinylidene fluoride (PVDF) films Fluorinated Ethylene Propylene (FEP) films Perfluoroalkoxy Polymer (PFA) films Ethylene Tetrafluoroethylene (ETFE) films Others

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Electrical & Electronics Industrial Automotive & Aerospace Medical & Pharmaceutical Consumer Products Others

Predominant Questions Answered in This Report Are:

1. Which segments will perform well in the Fluoropolymer Films market over the forecasted years? 2. In which markets companies should authorize their presence? 3. What are the forecasted growth rates for the market? 4. What are the long-lasting defects of the industry? 5. How share market changes their values by different manufacturing brands? 6. What are the qualities and shortcomings of the key players? 7. What are the major end results and effects of the five strengths study of industry?

Table of Content:

1 Scope of the Report 1.1 Market Introduction 1.2 Research Objectives 1.3 Years Considered 1.4 Market Research Methodology 1.5 Economic Indicators 1.6 Currency Considered 2 Executive Summary 3 Global Fluoropolymer Films by Players 4 Fluoropolymer Films by Regions 4.1 Fluoropolymer Films Market Size by Regions 4.2 Americas Fluoropolymer Films Market Size Growth 4.3 APAC Fluoropolymer Films Market Size Growth 4.4 Europe Fluoropolymer Films Market Size Growth 4.5 Middle East & Africa Fluoropolymer Films Market Size Growth 5 Americas 6 APAC 7 Europe 8 Middle East & Africa 9 Market Drivers, Challenges and Trends 9.1 Market Drivers and Impact 9.1.1 Growing Demand from Key Regions 9.1.2 Growing Demand from Key Applications and Potential Industries 9.2 Market Challenges and Impact 9.3 Market Trends 10 Global Fluoropolymer Films Market Forecast 11 Key Players Analysis 12 Research Findings and Conclusion

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ABOUT US:

Adroit Market Research is an India-based business analytics and consulting company. Our target audience is a wide range of corporations, manufacturing companies, product/technology development institutions and industry associations that require understanding of a markets size, key trends, participants and future outlook of an industry. We intend to become our clients knowledge partner and provide them with valuable market insights to help create opportunities that increase their revenues. We follow a code Explore, Learn and Transform. At our core, we are curious people who love to identify and understand industry patterns, create an insightful study around our findings and churn out money-making roadmaps.

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Stem Cell Therapy Market 2022 Growing with Major Eminent Key Players Anterogen Co., Ltd., MEDIPOST Co., Ltd., Osiris Therapeutics, Inc. and Pharmicell...

OPINION: What would happen if Roe v. Wade is overturned? – Westside Eagle Observer

So, what would happen if Roe v. Wade was overturned?

Should the Supreme Court overturn the Roe v. Wade decision of 1973, the issue would go back to the states, where it was prior to the 1973 decision -- where it constitutionally belongs -- and the federal government would, as before, have no jurisdiction over the issue.

It was taken from the states in violation of Amendment 10, which reserves powers not given to the federal government in Article I, Section 8, to the states or to the people, as described in the recent column, "The Word Abortion has never been in the Constitution."

Planned Parenthood would receive no federal allocations, so their extermination centers would largely disappear.

According to the Guttmacher Institute, there are 13 states that have banned most or all abortions. These are Arkansas, Idaho, Kentucky, Louisiana, Mississippi, Missouri, North Dakota, Oklahoma, South Dakota, Tennessee, Texas, Utah and Wyoming. Five additional states have a preexisting Roe v. Wade abortion ban on the books that would probably be reactivated. These are Alabama, Arizona, Michigan, West Virginia and Wisconsin. Yet another four states currently have laws banning abortion after the six-week mark which are currently ruled unconstitutional but probably would be reversed if Roe was overturned. Finally, another four states, Florida, Indiana, Montana and Nebraska, appear likely to ban or severely restrict abortion if Roe is overturned "based upon current legislative effort" (X22 Reports, Ep. 2767B -- Much to be Revealed Renegade Panicking, The Deal Keeps Iran Quiet, Control lost. May 4, 2022).

Twenty-six states, over half of the United States, would be likely to abandon abortion as an acceptable alternative to birth control. It is increasingly difficult to make babies pay for their right to exist when they have a heartbeat at six weeks old. The stain and stench of innocent blood are in the practice and cannot be hidden anymore.

Then too, revelations of genocide by Planned Parenthood in Idaho against black babies turn the stomachs of Christian and moral people. Project Veritas caught on tape a caller's question, "What about abortions for under-aged minority groups? The Planned Parenthood employee: "Certainly, and showed a willingness to accept larger donations to abort black babies!" "Caller: We just think ... You know ... the less black kids out there the better. Planned Parenthood employee: (laughs) Understandable! Understandable!"

Abortion is the Democrat Party's sacred cow. Virtually all Democrats look the other way (a form of approval) of the genocide of their own unwanted or inconvenient humankind. If racism and eugenics have merged with the party, as appears so in the conversation above to "kill off segments of the population," such is unacceptable in any society. Reportedly 79% of Planned Parenthood clinics are in minority neighborhoods (X22 Reports, Ep. 2767B, May 4, 2022, 27:00). Planned Parenthood founder Margaret Sanger certainly supported the eugenics of black babies.

This prompted Candace Owens to say, "If it wasn't for the abortion industry, the black population would be virtually doubled today" (Tucker Carlson). Let that sink in. If blacks ever come to recognize that they have been the targeted race of white Democrats for black eugenics, the Democratic Party would cease to exist overnight and Planned Parenthood facilities would likely be burned to the ground nationwide.

Another dark secret seems to be festering in Ukraine, already seen as the Deep State laundering capital of the world for dark money, bioweapons labs, illegal drugs, etc. JuliansRum posed the question, "Where do all these aborted-baby body parts go? And follows up with Ukraine as a "baby maker" operation. He asks: "Why is Ukraine at the world's forefront of fetal stem cell therapies? -- The first fetal stem cell treatment in humans occurred at the National Medical University of Ukraine. -- The world's first center to use fetal stem cells for therapeutic purposes in humans was founded in Kyiv, Ukraine. -- The world's first-ever fully licensed fetal stem cell bank was in Ukraine. -- The world's largest fetal stem cell therapy clinic (EmCell) is in Ukraine. Stem cell anti-aging therapy is big biz there." He ends with the observation that "Ukraine has become the self-styled stem cell capital of the world" (X22 Reports, Ep. 2767B -- May 4, 2022).

BBC News was the first news outlet to focus on Ukrainian research in the area ("Ukraine Babies in Stem cell probe," BBC News, by Matthew Hill, BBC Health Correspondent, Dec. 12, 2006). The column hypothesized, "There is heated debate about the ethics of using stem cells. Healthy newborn babies may have been killed in Ukraine to feed a flourishing international trade in stem cells, evidence obtained by BBC suggests." The report "describes a general culture of trafficking of children snatched at birth and a wall of silence from hospital staff upwards."

Why Ukraine? For the same reason 13 bioweapons labs existed there. The Deep State is the Ukrainian government and is unregulated in its dark science and dark money. Ukraine appears to be the world's Deep State playground for activities that civilized nations would never permit, such as "gain of function research" on human killer diseases and/or stem cell "research on live human cells." Far-fetched? Perhaps, but that is what they said about the "nonexistent" bioweapons labs before Putin took them out -- something no longer seriously disputed. Conspiracy theories have a history of becoming conspiracy realities when enough money is attached.

So what would happen to abortion if Roe v. Wade was overturned? Almost anything from returning the issue to the states in accordance with Amendment 10 to deeper revelations about eugenics on blacks in America to even darker revelations of stem cell research to preserve the youth of rich, old people -- all positive for ending the darkest chapter in the world's history.

Frankly, I believe America is tired of the guilt and shame which always accompany the practice.

Harold W. Pease, Ph.D., is an expert on the United States Consitution and a syndicated columnist. He has dedicated his career to studying the writings of the Founding Fathers and applying that knowledge to current events. He taught history and political science from this perspective for more than 30 years. To read more of his weekly articles, visit http://www.LibertyUnderFire.org. The opinions expressed are those of the author.

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OPINION: What would happen if Roe v. Wade is overturned? - Westside Eagle Observer

Hunting for the immune cells that predispose people to severe COVID-19 – EurekAlert

Some macrophages help the human body fight SARS-CoV-2 without systemic inflammation. But an aggressive subset of these immune molecules instead starts a cascade of events that can lead to multi-organ failure, researchers have discovered

image:Asst. Prof. Huanhuan Joyce Chen of Pritzker Molecular Engineering lead a new study showing that the type of macrophages present in a persons body might determine how likely they are to develop severe inflammation in response to COVID-19. view more

Credit: John Zich

When a virus makes its way into a persons body, one of the immune systems first responders is a set of pathogen-removal cells called macrophages. But macrophages are diverse; they dont all target viruses in the same way.

Researchers at the University of Chicagos Pritzker School of Molecular Engineering (PME) have discovered that the type of macrophages present in a persons body might determine how likely they are to develop severe inflammation in response to COVID-19. Their study has been published inNature Communications.

Clinicians know that COVID-19 can cause a spectrum of disease severity from mild to severe symptoms. Why some people, and not others, develop very severe disease has been a mystery, said Asst. Prof.Huanhuan Joyce Chen, who led the research with Qizhou Lian of the University of Hong Kong.This is the first time anyone has linked the variation in symptoms to macrophages.

A better model for COVID-19 infection Studying the cellular and molecular effects of the SARS-CoV-2 virus has been challenging for researchers who usually turn to model organisms to mimic human diseases; mice, rats, and many other animals dont develop the same COVID-19 symptoms as people. Thats why, shortly after the COVID-19 pandemic began, Chens group harnessed human stem cells to study the virus.

As reported previously in Nature, Chen and her colleagues grew stem cells into functioning mini-lungs and colonscalled lung and colon organoidsto probe the effects of SARS-CoV-2 on those organs and screen drugs to treat the virus.

In the new study, the researchers first analyzed lung biopsies from COVID-19 patients and discovered that they had especially high levels of macrophages. To better understand the role of macrophages during a COVID-19 infection, Chens team developed an approach that could exploit the same line of human stem cells to become both lung cells and macrophages simultaneously. The fact that they arose from the same initial stem cells was important to prevent the immune cells from attacking the lung cells.

This model system provides a perfect way to decode, step by step, how these three componentsthe immune system, the lungs, and the virusinteract, said Chen.

A cascade of inflammation When Chens lab infected the stem cell-derived lungs and macrophages with SARS-CoV-2, they found that not all macrophages responded in the same way. One subset, dubbed M2 macrophages, eliminate the virus by physically engulfing virus and virus-infected cells in a process known as phagocytosis, while releasing anti-inflammatory molecules.

M1 macrophages behaved in an opposite way: these cells released a plethora of inflammatory chemical signals that not only fight SARS-CoV-2, but cause a more widespread immune response. These same inflammatory factors have been shown to be present in the blood of people with severe COVID-19 symptoms.

Our results suggest that people who already have M1 macrophages activated in the lungs when infected with COVID-19 might be more likely to develop very severe inflammation from the virus, said Chen.

Elderly people and those with certain conditions like hypertension or diabetesalready known to be prone to more severe COVID-19 symptomsmay have higher levels of the M1 macrophages, she added.

Her team went on to show that antibodiessimilar to those already used clinically to treat COVID-19helped M2 macrophages clear the SARS-CoV-2 virus. More work is needed to show whether the observations hold true in humans, but the findings could help inform the prevention or treatment of severe COVID-19 in the most at-risk patients. And Chen is already thinking ahead to her next experiments with the stem cell-derived organoids.

This model system is useful for decoding the molecular mechanisms behind not only COVID-19, but other infectious diseases, said Chen.

In the future, her group hopes to make more complex mini-organs that include not only lung and immune cells, but blood vessels, nerves and other supporting cell types.

##

Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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Hunting for the immune cells that predispose people to severe COVID-19 - EurekAlert

Data at the 2022 ASCO Annual Meeting Highlight Genentech’s Continued Commitment to Innovation in Oncology and Personalized Healthcare – BioSpace

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)-- Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), today announced that new data from clinical trials of 18 approved and investigational medicines across more than 20 cancer types will be presented at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting, which will be held June 3-7, 2022. Genentech and its partners will present clinical studies across medicines, comprehensive genomic tests, and real-world data at this years meeting.

At ASCO this year, progress from our portfolio, partnerships and collaborations showcase our commitment to advance innovation in cancer care, said Levi Garraway, M.D., Ph.D., chief medical officer and head of Global Product Development. Were especially pleased to present data from our broad hematology portfolio, including pivotal data for glofitamab, a potential first-in-class bispecific antibody that may improve the lives of people with heavily pre-treated aggressive lymphoma.

Focusing on improving outcomes in non-Hodgkin lymphoma

New and updated data in non-Hodgkin lymphoma will be presented at ASCO. This includes pivotal data from the Phase II NP30179 study investigating glofitamab, an investigational CD20xCD3 T-cell engaging bispecific antibody, in heavily pre-treated patients with diffuse large B-cell lymphoma (DLBCL). DLBCL is an aggressive form of lymphoma, where as many as 40% of patients will relapse, at which point treatment options are limited and survival is shortened. Glofitamab is part of Genentechs broad bispecific antibody development program, which may offer a new immunotherapy-based approach to tackle a range of blood cancers. It is being investigated in several clinical trials including the STARGLO Phase III study, evaluating glofitamab in combination with gemcitabine and oxaliplatin (GemOx) versus MabThera/Rituxan (rituximab) in combination with GemOx in autologous stem-cell transplant ineligible relapsed or refractory DLBCL. In addition, key findings from an analysis of the Asia subpopulation from the pivotal Phase III POLARIX study investigating Polivy (polatuzumab vedotin) in combination with MabThera/Rituxan plus cyclophosphamide, doxorubicin and prednisone (R-CHP) in people with newly diagnosed DLBCL will be featured. Polivy plus R-CHP is the first treatment regimen to significantly improve outcomes in previously untreated DLBCL in more than 20 years, potentially transforming treatment for people with this disease.

Driving innovation in personalized cancer care

More than 20 new pieces of research from partnerships with Foundation Medicine will be presented, which continue to support innovation as well as progress in personalized cancer care. This includes new data from the Phase II Profiler02 study,* which investigates the use of a comprehensive genomic profiling testing panel from Foundation Medicine, with the aim of informing possible treatment decisions for patients based on their tumors unique genomic information.

Data from the imCORE network

Additionally, three abstracts from the Immunotherapy Centers Of Research Excellence (imCORE) Network will be presented at ASCO: a Phase I study** investigating autogene cevumeran (an mRNA-based individualized neoantigen-specific immunotherapy [iNeST]***) in the adjuvant setting of pancreatic ductal adenocarcinoma; a data mining study** evaluating intermediate endpoints for survival in metastatic breast cancer in the real-world setting; and a study identifying mechanisms of acquired resistance to immune checkpoint blockade.**

imCORE is an academic-industry network for scientific collaboration. Established by Genentech and connecting experts from 26 leading institutions around the globe, imCORE is committed to advancing and accelerating cancer immunotherapy research. imCORE is an example of Genentechs dedication to collaborating with the global cancer community to further understand cancer biology and immunology, help inform the development of potential future treatment, and transform patients lives.

Genentechs data presented at ASCO will feature its efforts to drive innovation and commitment to health equity through delivery of pioneering medicines and personalized cancer care that together improve outcomes for every patient while reducing the cost to society, inclusive clinical trials that remove barriers to participation, partnerships that multiply our ability to address challenges in cancer care, and bringing innovation into earlier stages of disease to maximize a chance of cure.

Overview of key presentations featuring Genentech medicines

Medicine

Abstract title

Abstract number

Blood cancer

Glofitamab

Glofitamab in patients (pts) with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) and 2 prior therapies: Pivotal Phase II expansion results

#7500

Mosunetuzumab

CELESTIMO: a Phase III trial evaluating the efficacy and safety of mosunetuzumab plus lenalidomide versus rituximab plus lenalidomide in patients with relapsed or refractory follicular lymphoma who have received 1 line of systemic therapy

#TPS7588

Polivy

Asia subpopulation analysis from the Phase III POLARIX trial

#7558

Initial safety run-in results of the Phase III POLARGO trial: polatuzumab vedotin plus rituximab, gemcitabine, and oxaliplatin in patients (pts) with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL)

#7551

Lung cancer

Tiragolumab

SKYSCRAPER-02: primary results of a Phase III, randomized, double-blind, placebo-controlled study of atezolizumab (atezo) plus carboplatin plus etoposide (CE) with or without tiragolumab (tira) in patients (pts) with untreated extensive-stage small cell lung cancer (ES-SCLC)

#LBA8507

Breast cancer

Giredestrant

Neoadjuvant giredestrant (GDC-9545) plus palbociclib (P) versus anastrozole (A) plus P in postmenopausal women with estrogen receptor-positive, HER2-negative, untreated early breast cancer (ER+/HER2 eBC): final analysis of the randomized, open-label, international Phase 2 coopERA BC study

#589

Inavolisib

Long-term safety of inavolisib (GDC-0077) in an ongoing Phase 1/1b study evaluating monotherapy and in combination (combo) with palbociclib (palbo) and/or endocrine therapy in patients (pts) with PIK3CA-mutated, hormone receptor-positive/HER2-negative (HR+/HER2) metastatic breast cancer (BC)

#1052

Tumor agnostic treatment and personalized healthcare

Rozlytrek

Efficacy/safety of entrectinib in patients (pts) with ROS1-positive (ROS1+) advanced/metastatic NSCLC from the Blood First Assay Screening Trial (BFAST)

#LBA9023

Rozlytrek

Trial in progress: a randomized Phase 3 study of entrectinib vs crizotinib in patients (pts) with locally advanced/metastatic ROS1 fusion-positive (fp) NSCLC with or without baseline CNS metastases (mets)

#TPS9141

Comprehensive genomic profiling

(IIS, Centre Lon Brard)

Increasing targeted therapy options for patients with relapsed cancer with broader somatic gene panel analysis from the primary tumor: The Profiler02 randomized Phase II trial*

#3130

Comprehensive genomic profiling

Clinical and genomic characteristics of patients with durable benefit from immune checkpoint inhibitors (ICI) in advanced non-small cell lung cancer (aNSCLC)

#9048

Comprehensive genomic profiling

ctDNA Shed as a Tool to Select Immune Checkpoint Inhibitors (ICPI) with or without Chemotherapy for Patients (pts) with advanced Non-small Cell Lung Cancer (aNSCLC)

#9045

Comprehensive genomic profiling

Trial in progress: LCMC LEADER Neoadjuvant Screening Trial: LCMC4 Evaluation of Actionable Drivers in Early Stage Lung Cancers

#TPS8596

Real world data

A real world (rw) evidence study quantifying the clinical value of multi-gene testing in early-stage lung adenocarcinoma (LUAD)

#8525

Real world data

Real world analysis of quantitative MET copy number (CN) as a biomarker in advanced NSCLC (aNSCLC)

#9123

Real world data

Ancestry-based differences in gene alterations in non-small cell lung cancer: real-world data using genetic ancestry analysis

#9125

imCORE,

ISR, Genentech

Identifying mechanisms of acquired immune escape from sequential, paired biopsies**

#2519

imCORE

ISR, Dana-Farber Cancer Institute

Real-World Progression-Free Survival (rwPFS) and Time to Next Line of Therapy (TTNT) as Intermediate Endpoints for Survival in Metastatic Breast Cancer: A Real World Experience**

#6520

imCORE

ISR, Memorial Sloan Kettering Cancer Center

Phase I Trial of Adjuvant Autogene Cevumeran, an Individualized mRNA Neoantigen Vaccine, for Pancreatic Ductal Adenocarcinoma**

#2516

* IIS, investigator-initiated study

** ISR, institution-sponsored research

*** jointly developed by Genentech and BioNTech

About Polivy (polatuzumab vedotin-piiq)

Polivy is a first-in-class anti-CD79b antibody-drug conjugate (ADC). The CD79b protein is expressed specifically in the majority of B cells, an immune cell impacted in some types of non-Hodgkins lymphoma (NHL), making it a promising target for the development of new therapies. Polivy binds to CD79b and destroys these B cells through the delivery of an anti-cancer agent, which is thought to minimize the effects on normal cells. Polivy is being developed by Genentech using Seagen ADC technology and is currently being investigated for the treatment of several types of NHL.

Polivy U.S. Indication

Polivy is a prescription medicine used with other medicines, bendamustine and a rituximab product, to treat diffuse large B-cell lymphoma in adults who have progressed after at least two prior therapies.

The accelerated approval of Polivy is based on a type of response rate. There are ongoing studies to confirm the clinical benefit of Polivy.

Important Safety Information

Possible serious side effects

Everyone reacts differently to Polivy therapy, so its important to know what the side effects are. Some people who have been treated with Polivy have experienced serious to fatal side effects. A patients doctor may stop or adjust a patients treatment if any serious side effects occur. Patients must contact their healthcare team if there are any signs of these side effects.

Nerve problems in arms and legs: This may happen as early as after the first dose and may worsen with every dose. If a patient already has nerve pain, Polivy may make it worse. The patients doctor will monitor for signs and symptoms, such as changes in sense of touch, numbness or tingling in hands or feet, nerve pain, burning sensation, any muscle weakness, or changes to walking patterns

Side effects seen most often

The most common side effects during treatment were:

Polivy may not be for everyone. A patient should talk to their doctor if they are:

These may not be all the side effects. Patients should talk to their healthcare provider for more information about the benefits and risks of Polivy treatment.

Report side effects to the FDA at (800) FDA-1088 or http://www.fda.gov/medwatch. Report side effects to Genentech at (888) 835-2555.

Please visit http://www.Polivy.com for the full Prescribing Information for additional Important Safety Information.

About Tecentriq (atezolizumab)

Tecentriq is a monoclonal antibody designed to bind with a protein called PD-L1. Tecentriq is designed to bind to PD-L1 expressed on tumor cells and tumor-infiltrating immune cells, blocking its interactions with both PD-1 and B7.1 receptors. By inhibiting PD-L1, Tecentriq may enable the re-activation of T cells. Tecentriq may also affect normal cells.

Tecentriq U.S. Indications

Tecentriq is a prescription medicine used to treat adults with:

See original here:
Data at the 2022 ASCO Annual Meeting Highlight Genentech's Continued Commitment to Innovation in Oncology and Personalized Healthcare - BioSpace

How the Metaverse Will Reshape Mental Health Therapy – Entrepreneur

Opinions expressed by Entrepreneur contributors are their own.

The tech industry has seen a seismic shift in awareness around the metaverse following Facebook's rebranding to Meta and announcements about its development from other tech leaders like Microsoft, AMD, Nvidia and Epic Games. However, it's true potential lies beyond gaming, social media and consumer technology. For one thing, therapy in this new format, could soon become the standard way to get and provide mental health care.

In this digital age of interconnectedness, our society has become more cut-off than ever before. A recent report by Harvard suggests that 36% of all Americans, including 61% of young adults, feel serious loneliness, which recent research indicates is a key risk factor for mental health conditions. One study by the American Cancer Society analyzed data from more than 580,000 adults and found that social isolation increases the risk of premature death for every race.

Unable to access face-to-face care during the pandemic, many people are turning to support online. As VR headsets grow in popularity, that same technology could soon become an essential tool for therapy that is more engaging than traditional telemedicine or mobile apps.

Related:Into theMetaverse: How Digital Twins Can Change the Business Landscape

Many healthcare companies are developing innovative new business models in the metaverse to solve current challenges. Companies that make therapy sessions more human will be the ones that will make the greatest impact on therapy in the metaverse.

Most people still prefer in-person care, as evidenced by a recent survey by The Harris Poll finding that 80% of US patients always prefer face-to-face visits. This is mainly because sessions that take place in a therapist's office provide a space away from everyday life, and can increase trust when compared to digital therapy.

Conversely,a recent pollconducted byBetterHelp, found that 35% of those surveyed claimed that their opinion of how a therapy session went, wasdependent on which day of the week the appointment took place, the weather outside (31%) or by recent current events (30%).

Thats why the metaverse care model has the potential to radically change how digital therapy is delivered. Simply put, its as close to being in-person as you can get.

Being able to access support without geographical limitations from the comfort of your home has already taken off with telemedicine, but the metaverse provides a much more life-like experience.

This new increased depth of immersion can create greater engagement, focus, and connectedness compared to other digital therapy solutions. The natural environments and the intuitive nature of the design can also lead to a greater bond between patients and providers. There is a possibility that treatment outcomes can be improved due to these potential benefits but more research is needed to find out the best way to deliver therapy through VR.

My company, Rocket VR Health, is getting ready to launch a clinical trial exploring the use of mental health therapy delivered via virtual reality in patients undergoing stem cell transplantation. We have partnered with Massachusetts General Hospital in Boston to take a well-researched conventional therapy program and transform it into an immersive VR treatment.

We hypothesize that the result will be a more effective, accessible, and data-driven approach to therapy, which could be invaluable not just for the participants in the trial, but also for countless individuals suffering from mental health conditions for years to come.

Related:The 3 Biggest Challenges to Marketing in theMetaverse

Despite all the Facebook and Web3 metaverse hype, the reality is VR headsets are expensive, and though usage is growing, its estimated that only 12.5 millionwere sold in 2021. The majority of the metaverses that currently exist are for entertainment and healthcare is typically much slower to catch on.

For starters, healthcare providers must ensure that they properly manage patient data and provide security that meets the highest standards of mental healthcare.

In addition, further research needs to be done to prove the efficacy of VR therapy and convince insurance companies to cover this new treatment delivery method. Were hoping that research like our study with Massachusetts General will help make the case. Previous research findings are positive, and the FDA approved the first VR software as a medical device to treat pain management. Meanwhile, insurance companies are already covering VR-based telemedicine.

Lastly, the most compelling therapy offerings will provide headsets to patients directly, so that access to the most well-researched, cutting-edge treatments isnt dependent upon individual purchases of VR technology by consumers.

The exciting news is that a small but growing group of researchers, technologists and investors are already beginning to overcome these challenges. Slowly but surely, the metaverse will be a bigger part of all of our lives, and given the proper attention mental health may prove to be one of its best use cases in due time.

Related:Why Intellectual Property Will Dominate NFTs

Originally posted here:
How the Metaverse Will Reshape Mental Health Therapy - Entrepreneur

Premature Ovarian Failure Treatment Market Size 2022 Share, New Trends, Industry News, Business Growth, Top Key Players Analysis to 2028 The Daily…

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Based on previous estimations, the studys goal is to project market sizes for specific categories and geographies in the coming years. The Premature Ovarian Failure Treatment market research is designed to offer both qualitative and quantitative information on the industry in each of the studys areas and countries. The research also includes a comprehensive analysis of the competitive landscape and key firms product offerings, as well as available micro market investment options for stakeholders.

Premature Ovarian Failure Treatment Market Segmentation, By Type

Premature Ovarian Failure Treatment Market Segmentation, By ApplicationByproduct

Premature Ovarian Failure Treatment Market Segmentation, By Region

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The research includes a SWOT analysis as well as a complete industry analysis based on Porters five forces model. It compares how different providers do in terms of revenue creation and client base. This study examines the competition landscape, capacity, and recent developments such as mergers, acquisitions, and investments of the following key competitors in the global Premature Ovarian Failure Treatment market. The report also covers some key suggestions that can help market participants to beat their competition.

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Information on key Premature Ovarian Failure Treatment market segments and sub-segments, including quantitative, qualitative, value, and volume data.

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Continued

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Premature Ovarian Failure Treatment Market Size 2022 Share, New Trends, Industry News, Business Growth, Top Key Players Analysis to 2028 The Daily...

Stem cell therapy offers a new hope to repair brain damage in newborns – Yahoo News UK

A few hours after Tom (not his real name) was born, he became restless and did not want to be breastfed. His mother noticed that his left arm and leg were shaking rhythmically something was not right.

Tom was immediately transferred to the neonatal intensive care unit. An MRI scan revealed that he had suffered a severe stroke. Doctors told Toms parents that there was no treatment they could give the child. He would probably be disabled.

Most people think of stroke as something that mainly affects the elderly, but it can also occur in newborn babies. These perinatal strokes happen when one of the major arteries to the brain becomes blocked, leading to a lack of blood supply and hence oxygen to certain brain areas. About one in 5,000 newborns have a stroke. It usually happens in the first few days after they are born.

Most of the babies will have problems later in life, with the severity of the problems depending on which brain areas were injured. These problems can include muscle tightness in the arms and legs (cerebral palsy), behaviour problems, learning difficulties and epilepsy.

No therapy exists for newborns with stroke. Researchers, including our own team at University Medical Center Utrecht, have been working on new treatments, one of which involves stem cells.

Stem cells have the ability to turn into many different cells in the body, and they are little factories of several growth factors (proteins that stimulate the growth of specific tissues). The theory is that if we can get stem cells into the damaged part of a babys brain, the stem cells growth factors will stimulate the brain to repair itself.

Earlier studies in animals showed that injecting stem cells into the brains of newborn mice with stroke dramatically reduced the amount of brain damage and disability they suffered. The experiments showed that the treatment was safe and had no side-effects in the mice. These animal studies gave us hope that the treatment would work in newborn babies, too, preventing a lifetime of disability.

Story continues

But how do you deliver stem cells to a babys brain without having to use needles or surgery? We decided to try an intranasal route (through the nose), which was tested in mice. After we delivered the stem cells intranasally, the cells travelled rapidly and specifically to the injured brain areas. The injured brain area sends out alarm signals which guide the stem cells to the right spot in the brain.

Once the stem cells arrived at the damaged area, they secreted growth factors that boosted the repair systems of the mices brains. Within a few days, the stem cells were broken down and not traceable in the brain any longer. After several experiments with this method, we concluded that dripping stem cells in the nose is the safest and most efficient way to deliver them to the brain.

After many years of laboratory research, we have finally tested the treatment in babies. The results have been published in The Lancet Neurology.

Baby Tom, mentioned earlier, was the first baby to participate in the study and received stem cells within a week of being born. To ask parents to enrol in an experimental therapy in the first week of their newborn childs life is a very delicate process.

After we had a long conversation with his parents, they decided to let their son take part in the study. He received stem cells via nose droplets, a procedure that took only several minutes. Afterwards, Tom was monitored closely for a few days before he went home.

We treated ten newborns who were transferred from hospitals across the Netherlands to the University Medical Center Utrecht after suffering from a stroke. In all ten newborns, the stem cell droplets were administered without any complications. There was one baby who had a mild fever after the treatment, which quickly cleared up on its own.

A follow-up MRI scan of the brain made three months after the stroke showed less injury than expected, possibly because of the stem cells. At four months, the treated babies, including Tom, performed well when the quality of their movements was tested. When the children are two years old, we will check their development again.

We are now looking for opportunities to proceed with a randomised controlled trial (the gold standard for medical studies) to prove that stem cell therapy can effectively repair brain injury after perinatal stroke.

The discovery of a new and safe therapy with stem cells also opens up opportunities for other babies with brain injury, such as babies who are born too early, or babies that suffer from a lack of oxygen during birth (perinatal asphyxia). Stem cell therapy gives hope to the most vulnerable patient group, with possible lifelong benefits.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

The Conversation

Nienke Wagenaar receives funding from Utrecht University, Wilhelmina Children's Hospital Research Fund, Royal Netherlands Academy of Arts and Sciences and the Research Training Centre of the Hospital for Sick Children. For previous work, including the PASSIoN study, she received funding from the Netherlands Organisation for Health Research and Development (ZonMW).

Lisanne Baak receives funding from the Netherlands Organisation for Health Research and Development (ZonMW).

Niek van der Aa receives funding from the Wilhelmina Children's Hospital Research Fund, Health Holland, Utrecht University and the Vaillant Fund.

Excerpt from:
Stem cell therapy offers a new hope to repair brain damage in newborns - Yahoo News UK