Category Archives: Stem Cell Treatment


Keithley’s Korner: Big benefits from Stem Cell Therapy – Ruidoso News

Tim Keithley, Guest columnist 7:45 a.m. MT March 2, 2017

Tim Keithley(Photo: Courtesy)

Like a lot of folks who love to go skiing, play tennis, and enjoy the Ruidoso year-round beautiful weather, I became discouraged when my right knee went out climbing down a staircase recently.

I waited a few days figuring that it might heal like it always has done before. But this time the injury felt different and seemed to be getting worse.

Turns out you have a torn tendon in your right knee, Dr. Steven Rath of Fusion Medical Spa said on New Mexico in the Morning.

It obviously wasnt going to heal itself, so we had Tim come in and consider stem cell therapy, Dr. Rath said. It turns out that we were able to help his body heal itself without putting him through painful knee surgery.

Within a day after the procedure this week, the knee was sore from having the shots injected right into the tendon, but the regular pain had subsided. It made me a believer in the stem cell therapy Dr. Rath has been talking about on the radio for some time.

Heres a simple explanation of the procedure: Dr. Rath draws your own blood, then separates out the healing platelets through a spinning process, then injects those back into your body to the specific area that needs healing.

Stem cell therapy is nothing new, but its still considered an alternative form of treatment and an experiment, Dr. Rath said. Part of the reason why insurance companies dont cover the procedure has to do with the fact that medical companies prefer patients have surgery when it may not be necessary.

There may be patients out there who definitely need surgery, but providing this procedure has kept many of my patients from having to go under the knife.

Having had the procedure done on my knee this week, I can testify that it works and has given me a new hope that soon Ill be back on the slopes and the tennis court without having the ordeal of potential knee surgery.

Thus far in my practice, stem cell therapy has helped many people in your same situation, Dr. Rath said.

Tim Keithley is the host of the New Mexico in the Morning radio show Monday through Friday, 9 to 10 a.m., on KRUI 1490 AM, KWMW 105.1 FM and 99.1 FM or live streaming at mtdradio.com.

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Keithley's Korner: Big benefits from Stem Cell Therapy - Ruidoso News

Angels Pitcher Put Off Surgery for Stem Cell Treatment – Athletic Business (blog)

Garrett Richards' first thought when he found out about his torn elbow ligament in May was to schedule Tommy John surgery as soon as possible.

It made sense, considering the ligament-replacement procedure has become the standard fix for such injuries. Plus, the Los Angeles Angels ace was familiar with the operating room, having had surgery for a ruptured patellar tendon he suffered on Aug. 20, 2014, toward the end of a breakout season.

Richards knew how to handle the seemingly interminable months of rehab, and he wanted to get the clock started on his return.

But a conversation with Angels head physical therapist Bernard Li convinced Richards to consider other alternatives, and in mid-May he tried a relatively novel treatment in which stem cells taken from bone marrow in his pelvis were injected into the damaged area.

Richards did not pitch again the rest of the year except for a stint in the instructional league, but he has been back on the mound throwing bullpen sessions since the first day of Angels camp and reported no problems.

This weekend, Richards anticipates pitching in a game for the first time since May 1, when his aching elbow forced him from a start after four innings.

"It's nice to know I'll be able to start the season this year and kind of pick up where I left off," Richards said.

A couple of lockers away, fellow starter Andrew Heaney had a different tale to tell.

The promising left-hander also went down with a torn ulnar collateral ligament early in the season, after making one start. Their ailments were the two biggest blows to an Angels rotation that was decimated by injuries, dooming the club to a 74-88 record and a fourth-place finish in the AL West.

Heaney also tried stem cell therapy, two weeks before Richards, both under the supervision of team doctor Steve Yoon. Heaney's ligament didn't heal, though, and after experiencing discomfort throwing after his rehab, he had Tommy John surgery July 1. He has been ruled out for the 2017 season.

"They tell you it's 50-50. It either works, or it doesn't," Heaney said of the stem cell procedure. "Obviously, me and Garrett are pretty much the proof of that rule."

Even with less-favorable odds than reconstructive surgery, which has an 80% success rate for returning to action and 67% for pitching 10 games or more, stem cell therapy is gaining acceptance as an option for pitchers with partial UCL tears. The recovery time is shorter -- three to five months instead of 12 to 18 -- and the treatment less invasive.

There are limitations. Biological approaches based on stem cells or platelet-rich plasma (PRP) won't repair a complete tear of the ligament. The location of the injury and its extent factor into the chances of success. And players whose ligaments don't recover, then have to have surgery, extending their window of time for returning to action.

Even then, the idea of healing without going under the knife is becoming increasingly appealing. New York Yankees ace Masahiro Tanaka treated the small tear in his elbow ligament with PRP and rehabilitation in 2014, sitting out 10 weeks but coming back to pitch in late September.

He's 26-11 with a 3.26 ERA over the last two seasons, raising the profile of PRP -- a procedure in which the player's own blood is used to promote healing of the injury -- as a non-surgical alternative.

Now Richards looms as the test case for stem cell treatment to fix partial UCL tears, which make up about 60-70% of these injuries. If the hard-throwing right-hander can return to his old form -- he was a Cy Young Award candidate before his knee injury in August2014 -- other pitchers in his situation are bound to at least consider the route he took.

"I hope this opens another path for guys," Richards said. "Obviously, if you can prevent being cut on and having surgery, that's the No.1 priority. I hope guys don't just jump right into Tommy John, that they at least explore this option."

Ageless veteran Bartolo Colon was the first pitcher widely known to have undergone stem cell therapy as he sought to recover from elbow and shoulder ailments in 2010. At the time, the ethics of the procedure were questioned, especially because the doctor who performed it, South Florida-based Joseph Purita, acknowledged using human growth hormone in previous treatments, though not in Colon's.

Since then, the use of stem cells has become more mainstream. They are the focus of Yoon's practice.

"As more and more people start to use it, you're getting a better sense for what it can and can't do," Yoon said. "Baseball definitely has opened up to it quite a bit, and as we see some of the successes like with Garrett, we're getting a better understanding that there's a lot of potential here with these types of treatment."

Yoon calls stem cell therapy a "super PRP" because it combines the curative properties of that treatment with more healing agents and says it can be used on tendon tears, muscle tears and strains and even to address degenerative joint disease.

However, much remains unknown about the benefits of stem cells. Lyle Cain, an orthopedist who has performed Tommy John surgeries and stem cell treatments at the Andrews Sports Medicine & Orthopaedic Center in Birmingham, Ala., said most of the research has been anecdotal, not scientific.

"We still don't have a good understanding even four or five years into it exactly what the stem cells do, what their method is," Cain said. "The theory is there's probably a chemical reaction where it releases chemicals in the cell that help the healing process.

"The stem cells aren't necessarily put in there with the thought they're going to become ligament, but there's probably a cellular chemical mechanism that helps the healing response."

And as Heaney discovered, they're not always effective. His tear was located farther down the arm, which reduced his chances of success with stem cell therapy. Richards was a better candidate because his injury, though deemed "high grade," was located within the ligament, like a slit on a rubber band.

But because Heaney was looking at likely missing most or all of 2017 even if he had surgery right away, he decided to try stem cells. The timing of the injury plays a major role in whether pitchers contemplate alternatives to surgery, with the more conservative approach often recommended if it happens early in the season.

Heaney said he doesn't regret taking that route and would have been upset if he had undergone the ligament-replacement operation right away, only to find out he could have returned to action quicker through another means.

"I'm glad it worked for him," he said of Richards. "It would have been really awful if it hadn't worked for either of us. Then we'd both look like idiots."

Their peers are paying attention. In a major league pitching community where about a quarter of its members have had Tommy John surgery, interest in the effectiveness of alternative cures is high.

The Los Angeles Dodgers' Brandon McCarthy was not a candidate because his ligament tore clear off the bone but said he had heard positive reports about stem cell treatment, not so much about PRP.

The Pittsburgh Pirates' Daniel Hudson, a veteran of two Tommy Johns, is encouraged as well.

"It's supposed to help repair the tissue. Before, ligaments just won't repair themselves," Hudson said. "It might keep a lot of guys from going under the knife."

That's Cain's hope. He regularly treats UCL tears on high school, college and minor league players with stem cells or PRP, but realizes there's heightened pressure on major leaguers to return to the field.

If more of them can do it without visiting an operating room, it would represent a major advancement for the players and the industry.

"There will be certain ligaments that are damaged enough that we don't have an answer; they have to reconstruct," Cain says. "But I think overall, if you look 15 years down the road, I suspect we'll be doing a lot more non-surgical treatment than surgical treatment."

Contributing: Gabe Lacques in Bradenton, Fla.

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Angels Pitcher Put Off Surgery for Stem Cell Treatment - Athletic Business (blog)

Local man fundraising for Stem Cell Transplant Therapy – Sequim Gazette

Spaghetti dinner fundraiser

Proceeds benefit stem cell transplant for Sean McKeown

When: 4-8 p.m. Saturday, March 4

Where: Sequim Boys & Girls Club, 400 West Fir St., Sequim

Admission: $10 for adults, $6 for children ages 10 and under

For more: Contact Karen McKeown at karenlmckeown@gmail.com or visit https://www.gofundme.com/seans-stem-cell-therapy

Sean McKeown has been living with multiple sclerosis for 17 years.

After trying every medication available to stop the progression of the disease, McKeown finally was approved for stem cell transplant therapy that could significantly help improve his condition.

It has been a 17-year journey for the McKeowns, as Sean and his wife Karen describe it. The two met in a Human Relations class at college in Bellingham and got married six months after Sean was diagnosed with multiple sclerosis.

They now have two young children, Madison, 13, and Dylan, 12, that attend Sequim Middle School.

Sean was born and raised in Port Angeles. The McKeowns have been living in Sequim for five years and work for the family owned business called All Weather Heating and Cooling, Inc. located off Kemp Street in Port Angeles.

Seans parents Tom and Ida McKeown opened the business in the 1980s and later sold it to Seans sister Jeanne Sparks and her business partner Dustin Halverson. Karen currently works as the office manager and Sean also worked at the business until 2009 when he could no longer work.

Sean was first diagnosed with multiple sclerosis in 2000 after experiencing double vision. He is no longer able to take the previous medication he was using for 10 years. Last September, he got a call from the University of Washington that notified him he tested positive for the JC Anti-virus for most people it would be similar to the common cold but when Sean contracts the virus it means half of the multiple sclerosis drugs can cause a second disease called PML or brain cancer.

It was a huge wake up call for us, said Karen.

Multiple sclerosis causes Seans legs to constantly shake and he must walk with the assistance of a cane every day. He also has a lack of energy and at one point was in a wheelchair for several months because he did not have the energy to walk short distances.

The McKeowns said they did a lot of research about stem cell transplant therapy for treating multiple sclerosis and Sean was approved for the procedure after he applied. His approval only lasts for 10 weeks but his insurance does not cover the procedure so the McKeowns must raise $16,000 to cover the cost.

The idea behind the treatment is to take Seans stem cells out of his fat areas, such as the stomach, put the cells through a machine that cleans it and creates new stem cells. Doctors will then inject the cells back into his body where they will attach to blood cells and start the healing process.

For multiple sclerosis, stem cell transplant therapy could help with Seans movement and Karen added that doctors want to put some stem cells in his brain.

Sean explained that the bodys nerve endings are almost like a wire, when talking about the process. He explained his T-cells are attacking the fatty tissue surrounding the nerve endings and when these cells get down to the wire or nerve endings the wires snap and short out, he said.

In theory, those stem cells will re-attach those wires, Karen explained.

StemGenex is the San Diego, Calif.-based facility where the McKeowns will travel to have the procedure done. Karen said the facility has been performing stem cell transplant therapy for nine years to treat other diseases such as Parkinsons. The treatment could be done within three days but if the McKeowns do not raise the money for the procedure within 10 weeks, they will have to reapply.

The McKeowns said they are hoping this procedure will allow Sean to have more energy.

For him, mainly it will be his energy level, Karen said. That would be a huge step in the right direction for him.

Karen explained there were days where Sean could barely walk out to the mailbox and back and would need to rest shortly after.

The McKeowns have been trying to raise money for the procedure through a GoFundMe account and a bank account through First Federal under Benefit for Sean McKeown.

The family also is hosting a fundraiser at the Boys &Girls club in Sequim this Saturday, March 4, where there will be a spaghetti dinner and raffle items. So far the McKeowns have raised an estimated $3,000 and the deadline to reach their goal amount is April 24.

For more information about Sean, you can visit https://www.gofundme.com/seans-stem-cell-therapy.

The spaghetti fundraiser will be held from 4-8 p.m. at the Sequim Boys &Girls Club, 400 West Fir St. in Sequim. Admission is $10 for adults and $6 for children ages 10 and under. Contact Karen McKeown at karenlmckeown@gmail.com.

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Local man fundraising for Stem Cell Transplant Therapy - Sequim Gazette

Stem cell therapy can help treat diabetic heart disease – The … – Economic Times

KARAIKAL: Recent advancements in stem cells research have given hope for successfully treating diabetic heart disease (DHD), renowned New Zealand-based researcher in cardiovascular diseases Dr Rajesh Katare said today.

DHD affected the muscular tissues of the heart leading to complications and it had been demonstrated that resident stem cells of myocardium can be stimulated to repair and replace e degenerated cardiac myocytes resulting in a novel therapeutic effect and ultimately cardiac regeneration, he said.

Katare, Director of Cardiovascular Research Division in the University of Otago, New Zealand, was delivering the keynote address at the continuing medical education programme on "Role of Micro-RNAs and stem cells in cardiac regeneration in diabetic heart disease" at the Karaikal campus of premier health institute JIPMER.

Presenting clinical evidences, Katare said stem cell therapy certainly presented a new hope for successfully treating DHD.

Jawaharlal Institute of Post Graduate Medical Education (JIPMER) Director Dr Subash Chandra Parija pointed out that it was the first such programme on the role of stem cells in cardiac regeneration in the whole of the country.

He said as diabetes was highly prevalent in the country, providing treatment for DHD had become a big challenge. Patients suffering from the condition have to undergo lifelong treatment and medications. "In this backdrop, advancements in stem cell therapy assume significance," he said.

Excerpt from:
Stem cell therapy can help treat diabetic heart disease - The ... - Economic Times

Stem cell therapy can help in treating diabetic heart disease – Business Standard

Recent advancements in stem cells research have given hope for successfully treating diabetic heart disease (DHD), renowned New Zealand-based researcher in cardiovascular diseases Dr Rajesh Katare said today.

DHD affected the muscular tissues of the heart leading to complications and it had been demonstrated that resident stem cells of myocardium can be stimulated to repair and replace e degenerated cardiac myocytes resulting in a novel therapeutic effect and ultimately cardiac regeneration, he said.

Katare, Director of Cardiovascular Research Division in the University of Otago, New Zealand, was delivering the keynote address at the continuing medical education programme on "Role of Micro-RNAs and stem cells in cardiac regeneration in diabetic heart disease" at the Karaikal campus of premier health institute JIPMER.

Presenting clinical evidences, Katare said stem cell therapy certainly presented a new hope for successfully treating DHD.

Jawaharlal Institute of Post Graduate Medical Education (JIPMER) Director Dr Subash Chandra Parija pointed out that it was the first such programme on the role of stem cells in cardiac regeneration in the whole of the country.

He said as diabetes was highly prevalent in the country, providing treatment for DHD had become a big challenge. Patients suffering from the condition have to undergo lifelong treatment and medications. "In this backdrop, advancements in stem cell therapy assume significance," he said.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

Original post:
Stem cell therapy can help in treating diabetic heart disease - Business Standard

All eyes on Garrett Richards, in hopes stem cells stave off Tommy … – USA TODAY

With MLB spring training underway, there's plenty to talk about. USA TODAY Sports

Garrett Richards is aiming to pitch through a ligament tear via stem cell therapy and other recovery methods.(Photo: Rick Scuteri, USA TODAY Sports)

TEMPE, Ariz. Garrett Richards first thought when he found out about his torn elbow ligament last May was to schedule Tommy John surgery as soon as possible.

It made sense, considering the ligament-replacement procedure has become the standard fix for such injuries. Plus, the Los Angeles Angels ace was familiar with the operating room, having undergone surgery for a ruptured patellar tendon he sustained on Aug. 20, 2014, toward the end of a breakout season.

Richards knew how to handle the seemingly interminable months of rehab, and he wanted to get the clock started on his return.

But a conversation with Angels head physical therapist Bernard Li convinced Richards to consider other alternatives, and in mid-May he tried a relatively novel treatment in which stem cells taken from bone marrow in his pelvis were injected into the damaged area.

Richards did not pitch again the rest of the year except for a stint in the instructional league, but he has been back on the mound throwing bullpen sessions since the first day of the Angels camp and reported no problems.

This weekend, Richards anticipates pitching in a game for the first time since May 1, when his aching elbow forced him from a start after just four innings.

Its nice to know Ill be able to start the season this year and kind of pick up where I left off, Richards said.

A couple of lockers away, fellow starter Andrew Heaney had a different tale to tell.

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The promising left-hander also went down with a torn ulnar collateral ligament early in the season, after making only one start. Their ailments were the two biggest blows to an Angels rotation that was decimated by injuries, dooming the club to a 74-88 record and a fourth-place finish in the AL West.

Heaney also tried stem cell therapy, two weeks before Richards, both under the supervision of team doctor Steve Yoon. Heaneys ligament didnt heal, though, and after experiencing discomfort throwing following his rehab, he had Tommy John surgery July 1. He has been ruled out for the 2017 season.

They tell you its 50-50. It either works or it doesnt, Heaney said of the stem cell procedure. Obviously, me and Garrett are pretty much the proof of that rule.

Even with less-favorable odds than reconstructive surgery, which has an 80% success rate for returning to action and 67% for pitching 10 games or more, stem cell therapy is gaining acceptance as an option for pitchers with partial UCL tears. The recovery time is shorter 3-5 months instead of 12-18 and the treatment less invasive.

There are limitations. Biological approaches based on stem cells or platelet-rich plasma (PRP) wont repair a complete tear of the ligament. The location of the injury and its extent factor into the chances of success. And players whose ligament doesnt recover, then have to undergo surgery, extend their window of time for returning to action.

Even then, the idea of healing without going under the knife is becoming increasingly appealing. New York Yankees ace Masahiro Tanaka treated the small tear in his elbow ligament with PRP and rehabilitation in 2014, sitting out 10 weeks but coming back to pitch in late September.

Hes 26-11 with a 3.26 ERA over the last two seasons, raising the profile of PRP a procedure in which the players own blood is used to promote healing of the injury as a non-surgical alternative.

Now Richards looms as the test case for stem cell treatment to fix partial UCL tears, which make up about 60-70% of these injuries. If the hard-throwing right-hander can return to his old form he was a Cy Young Award candidate before his knee injury in August 2014 other pitchers in his situation are bound to at least consider the route he took.

I hope this opens another path for guys, Richards said. Obviously, if you can prevent being cut on and having surgery, thats the No. 1 priority. I hope guys dont just jump right into Tommy John, that they at least explore this option.

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Ageless veteran Bartolo Colon was the first pitcher widely known to have undergone stem cell therapy as he sought to recover from elbow and shoulder ailments in 2010. At the time, the ethics of the procedure were questioned, especially because the doctor who performed it, South Florida-based Joseph Purita, acknowledged using human growth hormone in previous treatments, though not in Colons.

Since then, the use of stem cells has become more mainstream. They are the focus of Yoons practice.

As more and more people start to use it, youre getting a better sense for what it can and cant do, Yoon said. Baseball definitely has opened up to it quite a bit, and as we see some of the successes like with Garrett, were getting a better understanding that theres a lot of potential here with these types of treatment.

Yoon calls stem cell therapy a super PRP because it combines the curative properties of that treatment with more healing agents, and said it can be used on tendon tears, muscle tears and strains and even to address degenerative joint disease.

However, much remains unknown about the benefits of stem cells. Lyle Cain, an orthopedist who has performed both Tommy John surgeries and stem cell treatments at the Andrews Sports Medicine & Orthopaedic Center in Birmingham, Ala., said most of the research has been anecdotal, not scientific.

We still dont have a good understanding even four or five years into it exactly what the stem cells do, what their method is, Cain said. The theory is theres probably a chemical reaction where it releases chemicals in the cell that help the healing process. The stem cells arent necessarily put in there with the thought theyre going to become ligament, but theres probably a cellular chemical mechanism that helps the healing response.

And as Heaney discovered, theyre not always effective. His tear was located farther down the arm, which reduced his chances of success with stem cell therapy. Richards was a better candidate because his injury, though deemed high grade, was located within the ligament, like a slit on a rubber band.

But because Heaney was looking at likely missing most or all of 2017 even if he had surgery right away, he decided to try stem cells. The timing of the injury plays a major role in whether pitchers contemplate alternatives to surgery, with the more conservative approach often recommended if it happens early in the season.

Heaney said he doesnt regret taking that route, and would have been upset if he had undergone the ligament-replacement operation right away, only to find out he could have returned to action quicker through another means.

Im glad it worked for him, he said of Richards. It would have been really awful if it hadnt worked for either of us. Then wed both look like idiots.

Their peers are paying attention. In a major league pitching community where about a quarter of its members have undergone Tommy John surgery, interest in the effectiveness of alternative cures is high.

The Los Angeles Dodgers Brandon McCarthy was not a candidate because his ligament tore clear off the bone, but said he had heard positive reports about stem cell treatment, not so much about PRP.

The Pittsburgh Pirates Daniel Hudson, a veteran of two Tommy Johns, is encouraged as well.

Its supposed to help repair the tissue. Before, ligaments just wont repair themselves, Hudson said. It might keep a lot of guys from going under the knife.

Thats Cains hope. He regularly treats UCL tears on high school, college and minor-league players with stem cells or PRP, but realizes theres heightened pressure on major leaguers to return to the field.

If more of them can do it without visiting an operating room, it would represent a major advancement for both the players and the industry.

I think overall the biologic treatment of these injuries will certainly progress and it will be somewhat the wave of the future, Cain said. There will be certain ligaments that are damaged enough that we dont have an answer; they have to reconstruct. But I think overall, if you look 15 years down the road, I suspect well be doing a lot more non-surgical treatment than surgical treatment.

Contributing: Gabe Lacques in Bradenton, Fla.

More here:
All eyes on Garrett Richards, in hopes stem cells stave off Tommy ... - USA TODAY

Generous Teessiders fund mum’s 15000 trip to China for stem cell treatment – Gazette Live

A MUM has China in her sights thanks to the kindness of Tessiders.

The Gazette told last October how Teesville mum Jodie Hardwick, 29, was diagnosed with a muscle-wasting condition when she was 11 and has coped with life in a wheelchair - and deteriorating sight - ever since.

Her failing eyesight means she can only see children Rhys and Sian in silhouette - but pioneering stem cell surgery in China could change all that.

And thanks to the generosity of family, friends and many people she doesnt even know, shell be heading to the Far East in May.

With more than 12,000 of her 15,000 target raised, it means Jodie, mum Michelle and her aunty Julie Allport will be jetting out to Hong Kong at the end of May before travelling to the Shixin Hospital in Dongguan, on the Chinese mainland.

Its hoped the treatment she receives there, while not offering a cure for her Friedrichs Ataxia, could slow its progress and even bring back some of Jodies sight, hearing and muscle function.

Treatment on people with similar conditions has seen some improvement with their sight, speech and muscle control.

Its been a whirlwind few months of fundraising for the family - and theyre eager to say thanks to everyone who has helped.

Larger donations have included 2,500 from a fundraising night at the Dormans club in Middlesbrough, 1,000 from Blueline and Marton Taxis and 1,430 from two bucket collections at the Waterloo Road mosque in Middlesbrough.

The Club Bongo International, the Red Lion in Linthorpe and family and friends have also helped hugely with fundraising.

Mum Michelle said: Weve got most of the money in now - we just need that final push to reach the 15,000.

People have donated through the GoFundMe page but its mainly been through direct donations.

Its been unbelievable really, were so grateful. Jodies quiet astonished and excited - she didnt think it was going to happen.

Were flabbergasted at how generous people have been.

Visit http://www.gofundme.com/2tkcv4s.

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Generous Teessiders fund mum's 15000 trip to China for stem cell treatment - Gazette Live

Heart failure BREAKTHROUGH: Stem cells trial offers hope to millions – Express.co.uk

GETTY

A high-level meeting has paved the way for global trials to begin on hundreds of patients.

British scientists have found a way to use stem cells to repair damaged tissue which could help millions living with heart failure, the UKs leading cause of death.

Scarring due to disease or heart attacks affects more than two million people in Britain.

This would be the biggest breakthrough since the first transplants three decades ago

Professor Steve Westaby

Initial trials involving more than 100 patients are being planned for the autumn at two London hospitals.

World renowned cardiac surgeon Professor Steve Westaby, who helped pioneer the revolutionary technique, said it had been thought that repairing heart damage was impossible.

But results from a long-term trial that began in Greece five years ago have shown that this is not the case.

Preliminary data from this trial showed the engineered stem cells, known as Heartcel, can reverse scarring by up to 79 per cent.

The data, presented at the European Society of Cell and Gene Therapy in Florence, showed an average of 40 per cent reduction in heart damage in those on the treatment.

Last month researchers finalised talks with European and US regulators to discuss the timetable for global trials next year involving 500 people.

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6 early signs of a heart attack

Professor Westaby, from the John Radcliffe Hospital, Oxford, said: I am very excited at the prospect of a trial which will hopefully lead to the availability of this stem cell treatment to thousands of patients annually in the UK.

Other scientists have tried in vain to repair damaged heart muscle using stem cells over the past few decades.

This is the first time scarring has been shown to be reversible. It could herald an end to transplants and lead to a treatment for heart failure within three to five years.

GETTY

Professor Westaby said: This would be the biggest breakthrough since the first transplants three decades ago.

Professor Westaby has been working on the technique for more than a decade and is carrying out the study with Professor Kim Fox, head of the National Heart and Lung Institute, at Imperial College London.

The implanted stem cells were created by medical outfit Celixir, co-founded by Nobel laureate Professor Martin Evans, the first scientist to culture mice embryonic stem cells in a laboratory.

Professor Westaby was inspired to work on the breakthrough in 1999 after a four-month-old baby girls heart healed itself after he carried out a major life-saving operation.

Kirsty Collier, from Swindon, was dying of a serious and rare heart defect. In a last ditch effort Professor Westaby cut away a third of her badly damaged heart.

GETTY

GETTY

Surprisingly it began to beat. Fourteen years later a scan has shown that the heart had healed itself.

Now Kirsty, 18, has a normal one. Professor Westaby said: She was essentially dead and was only resurrected by what I regarded at the time as a completely bizarre operation.

The fact there was no sign of heart damage told me there were foetal stem cells in babies hearts that could remove scarring of heart muscle. That never happens in adults.

Its all down to the clues we got from Kirstys operation.

Read more:
Heart failure BREAKTHROUGH: Stem cells trial offers hope to millions - Express.co.uk

HealthWatch: Stem Cell Therapy for Osteoarthritis – WeAreGreenBay.com

CHICAGO. (Ivanhoe Newswire) -- Osteoarthritis is the most common form of arthritis in the U.S., affecting nearly 27 million adults. It is currently an incurable disease in which the joints deteriorate. Now, a therapy that has been used in eye surgery and to heal the skin of burn victims is being used for the first time in knees. This new form of treatment involves stem cells from amniotic fluid.

As a professional photographer, climbing up step ladders and walking down stairs are part of the daily grind for 65-year-old Linda Schwartz.

"There's constant activity; you're moving the whole time, really," Schwartz told Ivanhoe.

But the pain of osteoarthritis in both of her knees was making all that activity a little harder.

Schwartz detailed, "I tried cortisone shots. I had something called Euflexxa. I was sent to physical therapy twice. I mean, I did try acupuncture in my knees. But it didn't really seem to make a difference."

Adam Yanke, M.D., an orthopedic surgeon at Rush University Medical Center in Chicago, explained, "It's like the rubber on the tire. So as you start to lose the rubber in your tire and the rim hits the road, that's what happens when you have bone on bone arthritis and you've lost all the cartilage in your knee."

Dr. Yanke enrolled Schwartz in an experimental new therapy that involved injecting amniotic fluid that contained stem cells donated by healthy mothers into the knees of osteoarthritis patients.

"Between the two of those they're a potent anti-inflammatory and they also have growth factors that help promote healing or healthy growth of tissue," said Dr. Yanke.

It was by far the most effective pain treatment that Schwartz has tried. Unlike cortisone shots, there are no side effects. The pain relief has so far lasted up to a year.

"It was a very gradual feeling of it's a little bit better, it's a little bit better, and then realizing, wow, it's really pretty good," said Schwartz.

The one drawback is this therapy is not for patients whose arthritis is so bad it requires knee replacement surgery. Even though it's still in the experimental stage, Dr. Yanke offers the stem cell treatment to his patients. But at a cost of $2,200 a shot, it is not yet covered by insurance.

Contributors to this news report include: Cyndy McGrath, Supervising Producer; Jessica Sanchez, Field Producer; Milvionne Chery, Assistant Producer; Roque Correa, Editor.

MEDICAL BREAKTHROUGHS

RESEARCH SUMMARY

TOPIC: Stem Cell Therapy for Osteoarthritis

REPORT: MB #4213

BACKGROUND: Osteoarthritis, also known as degenerative joint disease or degenerative arthritis, is the most chronic condition in the joints, affecting 27 million Americans. This disease is an incurable one in which the tissue and bone in the joints deteriorate. Because the cartilage is a cushion between the bones, when this is lost a person can experience considerable pain, swelling and problems when moving the joint. This condition can affect people of any age, but it is more common in people over the age of 65. Some common risk factors include:

* Age

* Obesity

* Previous joint injury

* Overuse of the joint

* Weak thigh muscles

* Genetics

(Source: http://www.arthritis.org/about-arthritis/types/osteoarthritis/what-is-osteoarthritis.php)

TREATMENTS: Although there is no cure for osteoarthritis, there are several treatments that exist to treat it. Each treatment depends on the patient and the severity of the disease, but all focus on managing pain, stiffness and swelling; as well as joint mobility and flexibility. Some of these treatments are:

* Medications, like analgesics, nonsteroidal anti-inflammatory drugs, pills, cream and lotions

* Physical and occupational therapies

* Surgery

* Natural and alternative therapies like nutritional supplements, acupuncture, massages, physical activities, and weight management

(Source: http://www.arthritis.org/about-arthritis/types/osteoarthritis/treatment.php)

STEM CELL THERAPY: Stem cell therapy consists of a membrane product that also has amniotic fluid in it. They are usually used in eye surgery and to heal the skin of burned victims but now they're being used to treat osteoarthritis in an experimental therapy. The main goal of the trial is to demonstrate this is an adequate therapy for relieving inflammation in the joints. The therapy involves injecting amniotic fluid that contains stem cells donated by healthy mother into the knees of patients. Dr. Adam Yanke says it's too soon to tell if the stem cell therapy will actually help with growing back healthy tissue in order to avoid surgery, or if it will simply delay the process. Furthermore, the therapy can't be given to patients suffering from chronic arthritis and are in need of knee replacement surgery. Nevertheless, the treatment helps with pain relief, movement and there are no reported side effects.

(Source: Adam Yanke)

FOR MORE INFORMATION ON THIS REPORT, PLEASE CONTACT:

Deb Song

Media Relations

Deb_song@rush.edu

If this story or any other Ivanhoe story has impacted your life or prompted you or someone you know to seek or change treatments, please let us know by contacting Marjorie Bekaert Thomas at mthomas@ivanhoe.com

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HealthWatch: Stem Cell Therapy for Osteoarthritis - WeAreGreenBay.com

Thanks to Stem Cell Therapy, Thinning Hair May Be a Thing of the … – W Magazine

Call me a creature of habit, or just plain boring, but Ive been wearing my hair long, blonde, straight, and side-parted for more than 15 years. The only thing thats really changed is how much of it I have left. Whether the result of bleach, blowouts, stress, hormones, genetics, or all of the above, Ive been shedding like a cheap angora sweater since the age of 30. And, to make matters worse, the hair I do have is fine, fragile, and flyaway.

It wasnt always so. Flipping through old photo albums, I found evidence not only of my natural color (a long-forgotten brown) but also of the graphic, blunt bob I sported in my early 20s. I had oodles of hair back then and would smooth it to my head with pomade and push it behind my earsmuch like Guido Palau did on some of the models in Pradas spring runway show, I noted smugly.

Efforts in the ensuing years to save my ever-sparser strands have been all but futile. You name it, Ive tried it: platelet-rich plasma (PRP), treatments in which your own blood is spun down to platelets and injected into your scalp; mesotherapy (painful vitamin shots, also in the scalp); oral supplements; acupuncture; massage; herbal remedies; and high-tech hair products. Ive even resorted to wearing a silly-looking helmet that bathed my head in low-level laser light and was said to stimulate failing follicles. At this point, I would soak my mane in mares milk under the glow of a waxing supermoon if I thought it would help.

Since hair regeneration is one of the cosmetics-research worlds holiest grails (read: potential multibillion-dollar industry), Ive always hoped that a bona fide breakthrough was around the corner, and prayed it would arrive well ahead of my dotage. As it turns out, it might actually be a five-hour flight from New Yorkand around $10,000away.

It was the celebrity hairstylist Sally Hershberger who whispered the name Roberta F. Shapiro into my ear. You have to call her, she said. She is on to something, and it could be big. Shapiro, a well-respected Manhattan pain-management specialist, treats mostly chronic and acute musculoskeletal and myofascial conditions, like disc disease and degeneration, pinched nerves, meniscal tears, and postLyme disease pain syndromes. Her patient list reads like a whos who of the citys power (and pain-afflicted) elite, and her practice is so busy, she could barely find time to speak with me. According to Shapiro, a possible cure for hair loss was never on her agenda.

But thats exactly what she thinks she may have stumbled upon in the course of her work with stem cell therapy. About eight years ago, she started noticing a commonality among many of her patientsevidence of autoimmune disease with inflammatory components. Frustrated that she was merely palliating their discomfort and not addressing the underlying problems, Shapiro began to look beyond traditional treatments and drug protocols to the potential healing and regenerative benefits of stem cellsspecifically, umbilical cordderived mesenchymal stem cells, which, despite being different from the controversial embryonic stem cells, are used in the U.S. only for research purposes. After extensive vetting, she began bringing patients to the Stem Cell Institute, in Panama City, Panama, which she considers the most sophisticated, safe, and aboveboard facility of its kind. Its not a spa, or a feel-good, instant-fix kind of place, nor is it one of those bogus medical-tourism spots, she says. Lori Kanter Tritsch, a 55-year-old New York architect (and the longtime partner of Este Lauder Executive Chairman William Lauder) is a believer. She accompanied Shapiro to Panama for relief from what had become debilitating neck pain caused by disc bulges and stenosis from arthritis, and agreed to participate in this story only because she believes in the importance of a wider conversation about stem cells. If it works for hair rejuvenation, or other cosmetic purposes, great, but that was not at all my primary goal in having the treatment, Kanter Tritsch said.

While at the Stem Cell Institute, Kanter Tritsch had around 100 million stem cells administered intravenously (a five-minute process) and six intramuscular injections of umbilical cord stem cellderived growth factor (not to be confused with growth hormone, which has been linked to cancer). In the next three months, she experienced increased mobility in her neck, was able to walk better, and could sleep through the night. She also lost a substantial amount of weight (possibly due to the anti-inflammatory effect of the stem cells), and her skin looked great. Not to mention, her previously thinning hair nearly doubled in volume.

As Shapiro explains it, the process of hair loss is twofold. The first factor is decreased blood supply to hair follicles, or ischemia, which causes a slow decrease in their function. This can come from aging, genetics, or autoimmune disease. The second is inflammation. One of the reasons I think mesenchymal stem cells are working to regenerate hair is that stem cell infiltration causes angiogenesis, which is a fancy name for regrowing blood vessels, or in this case, revascularizing the hair follicles, Shapiro notes. Beyond that, she says, the cells have a very strong anti-inflammatory effect.

For clinical studies shes conducting in Panama, Shapiro will employ her proprietary technique of microfracturing, or injecting the stem cells directly into the scalp. She thinks this unique delivery method will set her procedure apart. But, she cautions, this is a growing science, and we are only at the very beginning. PRP is like bathwater compared with amniotic- or placenta-derived growth factor, or better yet, umbilical cordderived stem cells.

Realizing that not everyone has the money or inclination to fly to Panama for a treatment that might not live up to their expectations, Hershberger and Shapiro are in the process of developing Platinum Clinical, a line of hair products containing growth factor harvested from amniotic fluid and placenta. (Shapiro stresses that these are donated remnants of a live birth that would otherwise be discarded.) The products will be available later this year at Hershbergers salons.

With follicular salvation potentially within reach, I wondered if it might be time to revisit the blunt bob of my youth. I call Palau, and inquire about that sleek 1920s do he created for Prada. Fine hair can actually work better for a style like this, he says. In fact, designers often prefer models with fine hair, so the hairstyle doesnt overpower the clothing. Then he confides, Sometimes, if a girl has too much hair, we secretly braid it away. Say what? I know, its the exact opposite of what women want in the real world. But models are starting to realize that fine hair can be an asset. Look, at some point you have to embrace what you have and work with it. Wise words, perhaps, and proof that, like pretty much everything else, thick hair is wasted on the young.

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Thanks to Stem Cell Therapy, Thinning Hair May Be a Thing of the ... - W Magazine