Global Cell Therapy Market (2020 to 2025) – Growth, Trends, and Forecast – ResearchAndMarkets.com – Business Wire

DUBLIN--(BUSINESS WIRE)--The "Cell Therapy Market- Growth, Trends, and Forecast (2020 - 2025)" report has been added to ResearchAndMarkets.com's offering.

The cell therapy market will show rapid growth due to the increasing prevalence of chronic conditions, rising adoption of regenerative medicine and rise in the number of clinical studies pertaining to the development of cellular therapies.

Chronic diseases and conditions are on the rise worldwide. According to the World Health Organization, chronic disease prevalence is expected to rise by 57% by the year 2020. The emerging markets will be hardest hit, as population growth is anticipated be most significant in developing nations. Increased demand for healthcare systems due to chronic disease has thus become a major concern. Healthcare expenditures greatly increase, with each additional chronic condition with greater specialist physician access, emergency department presentations and hospital admissions.

Therefore the increasing prevalence of chronic conditions, government assistance and numerous companies investing heavily in stem cell therapy research and development will help to stimulate the industry growth. The proven effectiveness of cell therapy products coupled with increasingly favorable guidelines pertaining to cell therapy research and manufacturing should positively impact industry growth.

Companies Mentioned

Key Market Trends

Allogeneic Therapies Segment Accounted for the Largest Share in the Cell Therapy Market

Allogeneic therapies rely on a single source of cells to treat many patients. They increase the risk of eliciting an immune response within a patient, and immunosuppressive therapies are sometimes administered in combination with allogeneic products. Therefore there is an increasing inclination of physicians towards therapeutic use of allogeneic therapies coupled with rising awareness about the use of cord cells and tissues across various therapeutic areas is driving revenue generation.

Furthermore, the presence of a substantial number of approved products for clinical use has led to the large revenue share of this segment.

North America is Leading the Cell Therapy Market

North America is estimated to retain the largest share of the market due to the presence of strong regulatory framework in order to promote cellular therapy development, the existence of industry big shots, and high cost of therapies in the U.S. There is also the presence of leading universities that supports the research activities in the U.S. is one of the key factor driving the market for cell therapy in North America.

The Asia Pacific market is also increasing at a rapid rate due to the availability of therapies at lower prices coupled with growing awareness among the healthcare entities and patients pertaining the potential of these therapies in chronic disease management.

Key Topics Covered:

1 INTRODUCTION

2 RESEARCH METHODOLOGY

3 EXECUTIVE SUMMARY

4 MARKET DYNAMICS

4.1 Market Overview

4.2 Market Drivers

4.2.1 Increasing Prevalence of Chronic Conditions

4.2.2 Rising Adoption of Regenerative Medicine

4.2.3 Rise in Number of Clinical Studies Pertaining to the Development of Cellular Therapies

4.3 Market Restraints

4.3.1 High Cost of Therapies

4.4 Porter's Five Force Analysis

4.4.1 Threat of New Entrants

4.4.2 Bargaining Power of Buyers/Consumers

4.4.3 Bargaining Power of Suppliers

4.4.4 Threat of Substitute Products

4.4.5 Intensity of Competitive Rivalry

5 MARKET SEGMENTATION

5.1 By Type

5.1.1 Autologous

5.1.2 Allogeneic

5.2 By Therapy

5.2.1 Mesenchymal Stem Cell Therapy

5.2.2 Fibroblast Cell Therapy

5.2.3 Hematopoietic Stem Cell Therapy

5.2.4 Other Therapies

5.3 By Application

5.3.1 Musculoskeletal

5.3.2 Malignancies

5.3.3 Cardiovascular

5.3.4 Dermatology & Wounds

5.3.5 Other Applications

5.4 Geography

5.4.1 North America

5.4.1.1 United States

5.4.1.2 Canada

5.4.1.3 Mexico

5.4.2 Europe

5.4.2.1 Germany

5.4.2.2 United Kingdom

5.4.2.3 France

5.4.2.4 Italy

5.4.2.5 Spain

5.4.2.6 Rest of Europe

5.4.3 Asia-Pacific

5.4.3.1 China

5.4.3.2 Japan

5.4.3.3 India

5.4.3.4 Australia

5.4.3.5 South Korea

5.4.3.6 Rest of Asia-Pacific

5.4.4 Middle-East and Africa

5.4.4.1 GCC

5.4.4.2 South Africa

5.4.4.3 Rest of Middle East and Africa

5.4.5 South America

5.4.5.1 Brazil

5.4.5.2 Argentina

5.4.5.3 Rest of South America

6 COMPETITIVE LANDSCAPE

6.1 Company Profiles

6.1.1 Anterogen Co., Ltd.

6.1.2 Tego Science

6.1.3 Chiesi Farmaceutici S.p.A.

6.1.4 Corestem Inc.

6.1.5 Pharmicell Co Ltd.

6.1.6 Fibrocell Technologies Inc

6.1.7 Nipro Corp

6.1.8 MEDIPOST

6.1.9 TiGenix (Takeda Pharmaceuticals)

6.1.10 Stempeutics Research Pvt. Ltd.

7 MARKET OPPORTUNITIES AND FUTURE TRENDS

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Global Cell Therapy Market (2020 to 2025) - Growth, Trends, and Forecast - ResearchAndMarkets.com - Business Wire

Stem Cell Therapy Market Research, Technology, Demand, Analysis, Services, Type and Global Industry Forecast 2025 | Anterogen Co., Ltd. (South Korea),…

Introducing the Stem Cell Therapy Market: Gauging the Scope This versatile research report is presenting crucial details on market relevant information, harping on ample minute details encompassing a multi-dimensional market that collectively maneuver growth in the global Stem Cell Therapy Market. This holistic report presented by the report is also determined to cater to all the market specific information and a take on business analysis and key growth steering best industry practices that optimize million-dollar opportunities amidst staggering competition in Stem Cell Therapy market. The intricately presented market report is in place to unravel all growth steering determinants, presenting a holistic overview and analytical delivery governing the realms of opportunity diversification, a thorough review of challenges and threats to plan and deliver growth driven business strategies.

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A thorough assessment of the various facets of the market including segmentation reveals that the market has been categorized into prominent segments enlisting type, technology, applications as well as end-user segments. The report illustrates a vivid diversification of the segments in order to encourage wise and remunerative business discretion in the Stem Cell Therapy market. Analysis by Type: Various fact-based details about the diverse product types are housed in this section of the report to well identify the segment that reckons high investment returns. Analysis by Application: In the successive sections of the report, readers are presented with elaborate details on various applications in accordance to end-user needs across regions.

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Study on Table of Contents: Stem Cell Therapy Market Overview, Scope, Status and Prospect (2015-2020) covering COVID-19 Pandemic. Global Stem Cell Therapy Market Competition by Manufacturers Global Stem Cell Therapy Capacity, Production, Revenue (Value) by Region (2015-2020) Global Stem Cell Therapy Supply (Production), Consumption, Export, Import by Region (2015-2020) Global Stem Cell Therapy Production, Revenue (Value), Price Trend by Type Global Stem Cell Therapy Manufacturers Profiles/Analysis Stem Cell Therapy Manufacturing Cost Analysis Industrial Chain, Sourcing Strategy and Downstream Buyers Marketing Strategy Analysis, Distributors/Traders Global Stem Cell Therapy Market Effect Factors Analysis and Forecast (2020-2025)

Stem Cell Therapy Market Segmentation

Type Analysis of Stem Cell Therapy Market:

Based on cell source, the market has been segmented into,

Adipose Tissue-Derived Mesenchymal SCs Bone Marrow-Derived Mesenchymal SCs Embryonic SCs Other Sources

Applications Analysis of Stem Cell Therapy Market:

Based on therapeutic application, the market has been segmented into,

Musculoskeletal Disorders Wounds & Injuries Cardiovascular Diseases Gastrointestinal Diseases Immune System Diseases Other Applications

Investing in the Report: Know Why This report aims to holistically characterize and classify the Stem Cell Therapy market for superlative reader understanding A thorough evaluation to investigate material sources and downstream purchase developments are echoed in the report Elaborate references on purchaser needs, barrier analysis and opportunity assessment are also ingrained The report surveys and makes optimum forecast pertaining to market volume and value estimation

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Adroit Market Research is an India-based business analytics and consulting company incorporated in 2018. Our target audience is a wide range of corporations, manufacturing companies, product/technology development institutions and industry associations that require understanding of a markets size, key trends, participants and future outlook of an industry. We intend to become our clients knowledge partner and provide them with valuable market insights to help create opportunities that increase their revenues. We follow a code Explore, Learn and Transform. At our core, we are curious people who love to identify and understand industry patterns, create an insightful study around our findings and churn out money-making roadmaps.

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Stem Cell Therapy Market Research, Technology, Demand, Analysis, Services, Type and Global Industry Forecast 2025 | Anterogen Co., Ltd. (South Korea),...

CC-486 Constitutes Standard of Care for Subset of Patients with AML – Targeted Oncology

Older patients with acute myeloid leukemia are traditionally treated with intensive induction chemotherapy and derive benefit, but responses are not durable, and the overall survival (OS) with this treatment in short. It was hypothesized by Guillermo Garcia-Manero, MD et al, that maintenance therapy for post-remission AML might improve upon survival in the patient population, and the phase 3 QUAZAR AML-001 clinical trial was designed to investigate the hypothesis.

The oral hypomethylating agent, CC-486 induced a statistically significant improvement in OS compared with placebo in patients with AML, according to results from QUAZAR AML-001 (NCT0175753). These study findings recently drove the FDAs decision to approve the drug as a maintenance treatment for adult patients with AML who achieved a first complete remission or with incomplete blood count recovery after intensive induction chemotherapy and who are unable to complete intensive curative therapy.

The OS observed with CC-486 in QUAZAR AML-001 was 24.7 months compared with 14.8 months with placebo (HR, 0.69; 95% CI, 0.55-0.86;P=.0009). In addition to the OS benefit, relapse-free survival (RFS) was improved with CC-486 at 10.2 months compared to only 4.8 months with placebo(HR, 0.65; 95% CI, 0.52-0.81;P=.0001). During the presentation of these findings at the 2019 American Society of Hematology (ASH) Annual Meeting, the investigators concluded that CC-482 is the first agent used in the maintenance setting to show statistically significant and clinically meaningful improvements in both OS and RFS in post-remission patients with AML.

In an interview with Targeted Oncology following the FDA approval of CC-486, Dr. Garcia-Manero, professor, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, discussed the key findings from the QUAZAR AML-001 study and the importance of the FDA approval of CC-486 in post-remission AML.

TARGETED ONCOLOGY: It is known that azacitidine injection is effective for the treatment of AML, but why was is necessary to develop a new form of this drug?

Garcia-Manero: We refer to these drugs as hypomethylating agents. The issue with them is that if the patient responds to them, this requires therapy that could last for multiple months or years. We have 2 hypomethylating agents now, which are decitabine and azacitidine. The agents are usually given for five days a month or sometimes seven consecutive days a month.

This means some patients have to take IV or subcutaneous injections every week for the rest of their life.Because of this, weve been trying to develop an oral hypomethylating agent for about 50 years, and its exciting that we finally have it.

TARGETED ONCOLOGY: What was the rationale for the QUAZAR AML-001 clinical trial?

Garcia-Manero: This was a very interesting study where patients with AML that were in remission were treated in a randomized fashion with azacitadine tablets or a control. The problem with AML is relapse and there have been multiple trying this concept of maintenance therapies to see if some type of low-dose intensive chemotherapy approach would improve survival.

TARGETED ONCOLOGY: What were the key findings of the QUAZAR AML-001 study? What was the safety profile observed with CC-486 in this study?

Garcia-Manero: This is the first study where we see a survival benefit that is quite significant with the hypomethylating agent CC-486, which is a consolidation therapy approach rather than doing nothing.

The data are highly significant in terms of improvement in OS. It is close to 10 months which we have not seen in the past with almost no intervention. The only intervention performed was stem cell transplantation.

The toxicity profile of the compound was well tolerated. That said, these kinds of drugs are mild forms of chemotherapy and therefore can induce cytopenia or mild gastrointestinal toxicities.

TARGETED ONCOLOGY: Now that CC-486 is FDA approved, what will be the overall impact of this drug in the AML treatment landscape?

Garcia-Manero: Theres an interesting shift in the landscape because another oral hypomethylating agent (decitabine) was approved by the FDA last month. For CC-486, in particular, I think were going to have to decide what the role of the drug is outside its current indication of post-consolidation maintenance therapy because this CC-486 is not exactly like azacitadine, it has a different pharmacokinetic and pharmacodynamic profile. We are going to have to design new studies in AML and myelodysplastic syndrome. Right now, the role of CC-486 is clearly post-consolidation maintenance therapy.

TARGETED ONCOLOGY: How would you advise oncologists to use CC-486 in practice, now that is available?

Garcia-Manero: In my opinion, using for CC-486 in patients that have completed consolidation therapy, or who are not candidates for stem cell transplantation or had significant toxicity from consolidation, the data from QUAZAR constitute using CC-486 as the standard of care. I would advise using this maintenance approach for this patient population.

If a patient can undergo stem cell transplantation, that should be considered over CC-486. I think the future, we should also pay attention to particular genetic alterations of the patients because there may be a specific subset of patient mutated disease that may be candidates for other targeted agents instead of CC-486.

Reference:

Wei A,DohnerH, Pocock C, et al. The QUAZAR AML-001 Maintenance Trial: Results of a Phase III International, Randomized, Double-Blind, Placebo-Controlled Study of CC-486 (Oral Formulation ofAzacitidine) in Patients with Acute Myeloid Leukemia (AML) in First Remission.Blood .2019;134(suppl 2):LBA3.doi:10.1182/blood-2019-132405.

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CC-486 Constitutes Standard of Care for Subset of Patients with AML - Targeted Oncology

Covid-19 Impact on Global Cell Therapy Market 2020 Outlook: Industry Insights, Statistics, Shares and Forecasts to 2025 – The Daily Chronicle

Introduction & Scope: Global Cell Therapy Market

Global Cell Therapy market research report presentation demonstrates and presents an easily understandable market depiction, lending crucial insights on market size, market share as well as latest market developments and notable trends that collectively harness growth in the global Cell Therapy market. Research analysts and industry experts through this report are also aiming to lend ample light on further essential determinants such as a meticulous review and analytical take of opportunity assessment, also encompassing threat and challenge analysis that constantly deter upward growth spurt in Cell Therapy market.

Leading Companies Reviewed in the Report are:

JCR Pharmaceuticals Co., Ltd., Kolon TissueGene, Inc.; and Medipost and many more.

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Gauging COVID-19 Impact

To enable mindful business discretion amidst catastrophic developments such as COVID-19 and its subsequent implications, this ready-to-refer research report on the global Cell Therapy market is designed to answer the queries pertaining to the pandemic to emerge from catastrophic implications.

This intensively compiled research report presentation is a versatile hub of innate knowledge factors such as sales volume and bulk production, pricing matrix and sales figures, overall growth review and margin, chances of growth in the future and their range amongst other additional growth determinants that influence growth in the Cell Therapy market.

Regional Analysis

Furthermore, the report helps as a expedient guide to design and instrument probable growth routing activities across select regional hubs in the Cell Therapy market. Frontline companies and their result-based growth approaches are also recruited in the report to emulate growth.

In addition to in its succeeding sectors of the report, this detailed presentation of the Cell Therapy market offers vigorous details on regional belts and expansion projects identifying potential growth possibilities.

Quick Read Table of Contents of this Report @ https://www.adroitmarketresearch.com/industry-reports/cell-therapy-market

Global Cell Therapy Market is segmented based by type, application and region.

Based on Type, the Market has been segmented into:

By Use & Type Outlook, (Clinical-use,By Cell Therapy Type,,Non-stem Cell Therapies,Stem Cell Therapies,BM, Blood, & Umbilical Cord-derived Stem Cells,Adipose derived cells,Others), By Therapeutic Area, (Malignancies,Muscoskeletal Disorders,Autoimmune Disorders,Dermatology,Others,Research-use), By Therapy Type, (Allogenic Therapies,Autologous Therapies)

According to research inputs, this global Cell Therapy market is also likely to register a thumping growth of USD xx million in 2020 and is further anticipated to reach over xx million USD by the end of 2027, clocking at a steady CAGR of xx% through the forecast span, 2020-27. Expert opinion also suggests that the global Cell Therapy market is likely to tread on the road to recovery in the foreseeable future.

Five-Pointer Guide for Report Investment

* A rigorous, end-to-end review and analysis of the Cell Therapy market events and their implications

* A thorough compilation of broad market segments

* A complete demonstration of best in-industry practices, mindful business decisions and manufacturer activities that steer revenue sustainability in the global Cell Therapy market

* A complete assessment of competition spectrum, inclusive of relevant details about key and emerging players

* A pin-point review of the major dynamics and dominant alterations that influence growth in the global Cell Therapy market

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Adroit Market Research is an India-based business analytics and consulting company incorporated in 2018. Our target audience is a wide range of corporations, manufacturing companies, product/technology development institutions and industry associations that require understanding of a Markets size, key trends, participants and future outlook of an industry. We intend to become our clients knowledge partner and provide them with valuable Market insights to help create opportunities that increase their revenues. We follow a code- Explore, Learn and Transform. At our core, we are curious people who love to identify and understand industry patterns, create an insightful study around our findings and churn out money-making roadmaps.

Contact Us :

Ryan Johnson Account Manager Global 3131 McKinney Ave Ste 600, Dallas, TX75204, U.S.A. Phone No.: USA: +1 972-362 -8199/ +91 9665341414

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Covid-19 Impact on Global Cell Therapy Market 2020 Outlook: Industry Insights, Statistics, Shares and Forecasts to 2025 - The Daily Chronicle

Stem Cell Therapy Market to Fuel Revenues Through 2020 Lake Shore Gazette – Lake Shore Gazette

Stem cells are most vital cells found in both humans and non-human animals. Stem cells are also known as centerpiece of regenerative medicine. Regenerative medicines have capability to grow new cells and replace damaged and dead cells. Stem cell is the precursors of all cells in the human body. It has the ability to replicate itself and repair and replace other damaged tissues in the human body. In addition, stem cell based therapies are used in the treatment of several chronic diseases such as cancer and blood disorders.

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The global stem cell therapy market is categorized based on various modes of treatment and by therapeutic applications. The treatment segment is further sub-segmented into autologous stem cell therapy and allogeneic stem cell therapy. The application segment includes metabolic diseases, eye diseases, immune system diseases, musculoskeletal disorders, central nervous system disorders, cardiovascular diseases and wounds and injuries.

In terms of geographic, North America dominates the global stem cell therapy market due to increased research activities on stem cells. The U.S. represents the largest market for stem cell therapy followed by Canada in North America. However, Asia is expected to show high growth rates in the next five years in global stem cell therapy market due to increasing population. In addition, increasing government support by providing funds is also supporting in growth of the stem cell therapy market in Asia. China and India are expected to be the fastest growing stem cell therapy markets in Asia.

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In recent time, increasing prevalence of chronic diseases and increasing funds from government organizations are some of the major drivers for global stem cell therapy market. In addition, rising awareness about stem cell therapies and increasing focus on stem cell research are also supporting in growth of global stem cell therapy market. However, less developed research infrastructure for stem cell therapies and ethical issues related to embryonic stem cells are some of the major restraints for global stem cell therapy market. In addition, complexity related with the preservation of stem cell also obstructs the growth of global stem cell therapy market.

Some of the major companies operating in the global stem cell therapy market are Mesoblast Ltd., Celgene Corporation, Aastrom Biosciences, Inc. and StemCells, Inc.

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To support companies in overcoming complex business challenges, we follow a multi-disciplinary approach. At PMR, we unite various data streams from multi-dimensional sources. By deploying real-time data collection, big data, and customer experience analytics, we deliver business intelligence for organizations of all sizes.

Our client success stories feature a range of clients from Fortune 500 companies to fast-growing startups. PMRs collaborative environment is committed to building industry-specific solutions by transforming data from multiple streams into a strategic asset.

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Stem Cell Therapy Market to Fuel Revenues Through 2020 Lake Shore Gazette - Lake Shore Gazette

ERC-funded postdoctoral position at the Institut of Human Genetics, – Nature.com

The University Hospital Heidelberg is one of the major healthcare centers in Germany. Our objective is the development of innovative diagnostics and therapies as well as their quick implementation for the patient. With about 10,700 employees in more than 50 specialized clinical departments with almost 2,000 beds, about 80,000 patients in part-time and full-time inpatient treatment as well as 1,000,000 patients in ambulant treatment are medicated each year.

JobID: P0025V280

Location: Institut of Human Genetics, INF 366, 69120 Heidelberg Contract: 2 years with extension possibilities, begin as soon as possible Salary: Competitive, subject to skills and experience

The newly created Nephrogenetics unit headed by Matias Simons is looking for an enthusiastic postdoc to join our research group at the Institute of Human Genetics of the University Hospital Heidelberg. The general interest of the lab is in the molecular mechanisms underlying hereditary kidney and metabolic diseases. Most of these diseases are caused by single-gene defects and thereby offer unique opportunities to decipher fundamental regulatory pathways of human physiology and to develop targeted diagnostic and therapeutic options. Recent publications include Marchesin et al, Cell Rep 2020; Bedin et al, J Clin Invest 2019; Goncalves et al, PloS Genetics 2018; Simons, JASN 2018; Rujano et al, J Exp Med 2017; Trepiccione et al, JASN 2016; Gleixner et al, Cell Rep 2014. We combine human genetics with several experimental approaches, including fly and mouse genetics, cell culture, microscopy and biochemistry. For more info on the lab see http://www.simons-lab.de.

We offer an exciting project aimed at exploring the role of random monoallelic expression in renal development and homeostasis. For this project, we invite applications from individuals with a solid background in molecular cell biology. Prior experience with stem cells (e.g. mouse ESCs), organoids, single cell RNA-seq, epigenetics and kidney research is an advantage but not a prerequisite. The projects will be carried out in a stimulating work environment with scientific collaborations within the institute, across the Heidelberg life science community (e.g. EMBL, DKFZ) and worldwide.

The successful applicant will have good communication and organisational skills and a PhD in a relevant area (or be in the final stages of completion). We also invite applications from research-oriented MDs. Candidates are expected to be highly motivated and to work independently with a strong work ethic. As we are an international lab, profictiency in English language is a requirement. Applications including a cover letter, a detailed CV including a publication list and contacts of up to three referees should be sent as soon as possible to matias.simons@med.uni-heidelberg.de

The University Hospital Heidelberg offers:

http://www.klinikum.uni-heidelberg.de/karriere

We stand for equal opportunities. People with disabilities are given priority with the same suitability. The university hospital aims at a general increase in the proportion of women in all areas and positions where women are underrepresented. Qualified women are therefore particularly encouraged to apply.

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ERC-funded postdoctoral position at the Institut of Human Genetics, - Nature.com

Omeros Corporation : – Expert Panel Points to Central Role of Endothelial Injury and Lectin Pathway Activation in Critically Ill COVID-19 Patients -…

SEATTLE - Omeros Corporation (Nasdaq: OMER) today announced that the Demy-Colton Virtual Salon Series featured an expert discussion of developments in the treatment of severe COVID-19.

The panel session, entitled Lessons from Bergamo: Discoveries in Treating Critically-ill COVID-19 Patients, was held on September 2, 2020 and included international experts in hematology, oncology and complement science. The panel was moderated by Sara Jane Demy, founder and chief executive officer of Demy-Colton. A replay of the panel can be viewed here (free registration required).

The panel discussed the emerging evidence that endothelial injury and the activation of the lectin pathway of complement are central drivers of the acute respiratory distress syndrome (ARDS) and thrombosis seen in critically ill COVID-19 patients. Narsoplimab, Omeros' investigational human monoclonal antibody targeting mannan-binding lectin-associated serine protease-2 (MASP-2), the key effector of the lectin pathway of complement, was identified as a potentially highly effective therapy to treat critically ill COVID-19 patients.

Omeros previously announced positive results from the treatment with narsoplimab of six critically ill COVID-19 patients under a compassionate use protocol. All patients initially required mechanical ventilation and, following treatment with narsoplimab, all recovered, survived and were discharged from the hospital.

About Narsoplimab

Narsoplimab, also known as 'OMS721,' is an investigational human monoclonal antibody targeting mannan-binding lectin-associated serine protease-2 (MASP-2), a novel pro-inflammatory protein target and the effector enzyme of the lectin pathway of complement. Importantly, inhibition of MASP-2 does not appear to interfere with the antibody-dependent classical complement activation pathway, which is a critical component of the acquired immune response to infection. Omeros controls the worldwide rights to MASP-2 and all therapeutics targeting MASP-2.

Phase 3 clinical programs are in progress for narsoplimab in hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA), in immunoglobulin A (IgA) nephropathy, and in atypical hemolytic uremic syndrome (aHUS). The FDA has granted narsoplimab breakthrough therapy designations for HSCT-TMA and for IgA nephropathy; orphan drug status for the prevention (inhibition) of complement-mediated thrombotic microangiopathies, for the treatment of HSCT-TMA and for the treatment of IgA nephropathy and fast track designation for the treatment of patients with aHUS. The European Medicines Agency has granted orphan drug designation to narsoplimab for treatment in HSCT and for treatment of primary IgA nephropathy.

About Omeros Corporation

Omeros is a commercial-stage biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market and orphan indications targeting inflammation, complement-mediated diseases, disorders of the central nervous system and immune-related diseases, including cancers. In addition to its commercial product OMIDRIA (phenylephrine and ketorolac intraocular solution) 1%/0.3%, Omeros has multiple late-stage clinical development programs focused on complement-mediated disorders, including COVID-19, and substance abuse. A rolling biologics license application for narsoplimab, the company's lead MASP-2 inhibitor, in hematopoietic stem cell transplant-associated thrombotic microangiopathy is being completed for submission to the U.S. FDA. Omeros also has a diverse group of preclinical programs including GPR174, a novel target in immuno-oncology that modulates a new cancer immunity axis recently discovered by Omeros. Small-molecule inhibitors of GPR174 are part of Omeros' proprietary G protein-coupled receptor (GPCR) platform through which it controls 54 new GPCR drug targets and their corresponding compounds. The company also exclusively possesses a novel antibody-generating platform.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, which are subject to the 'safe harbor' created by those sections for such statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as 'anticipate,' 'believe,' 'can,' 'could,' 'estimate,' 'expect,' 'goal,' 'intend,' 'likely', 'look forward to,' 'may,' 'on track,' 'plan,' 'potential,' 'predict,' 'project,' 'prospects,' 'scheduled,' 'should,' 'slated,' 'targeting,' 'will,' 'would' and similar expressions and variations thereof. Forward-looking statements, including statements regarding anticipated regulatory submissions, the timing and results of ongoing or anticipated clinical trials, and the therapeutic application of Omeros' investigational product, are based on management's beliefs and assumptions and on information available to management only as of the date of this press release. Omeros' actual results could differ materially from those anticipated in these forward-looking statements for many reasons, including, without limitation, availability and timing of data from clinical trials and the results of such trials, unproven preclinical and clinical development activities, regulatory oversight, intellectual property claims, competitive developments, litigation, and the risks, uncertainties and other factors described under the heading 'Risk Factors' in the company's Annual Report on Form 10-K for the year ended December 31, 2019, filed with the Securities and Exchange Commission (SEC) on March 2, 2020, as supplemented by its Quarterly Report on Form 10-Q filed with the SEC on August 10, 2020 and subsequent filings with the SEC. Given these risks, uncertainties and other factors, you should not place undue reliance on these forward-looking statements, and the company assumes no obligation to update these forward-looking statements, whether as a result of any new information, future events or otherwise, except as required by applicable law.

Contact:

Jennifer Cook Williams

Tel: 360.668.3701

Email: jennifer@cwcomm.org

(C) 2020 Electronic News Publishing, source ENP Newswire

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Omeros Corporation : - Expert Panel Points to Central Role of Endothelial Injury and Lectin Pathway Activation in Critically Ill COVID-19 Patients -...

Animal Stem Cell Therapy Market 2020 with Top Countries Data : Market Size, Growth, Segments, Revenue, Top Manufacturers and Forecast to 2024 -…

Animacel

Scope of the Animal Stem Cell Therapy Market Report:The classification of animal stem cell therapy includes dogs, horses and others. And the proportion of dogs in 2020 is about 50.42%, and the proportion is in increasing trend from 2013 to 2020.North America is the largest consumption region of animal stem cell therapy, with a consumption market share nearly 58.63% in 2020. Japan is the second largest supplier of animal stem cell therapy, enjoying production market share nearly 15.17% in 2020.

The worldwide market for Animal Stem Cell Therapy is expected to grow at a CAGR of roughly 38.3% over the next five years, will reach 110 million US$ in 2024, from 16 million US$ in 2019, According to a New Research study.

This report focuses on the Animal Stem Cell Therapy in global market, especially in North America, Europe and Asia-Pacific, South America, Middle East and Africa. This report categorizes the market based on manufacturers, regions, type and application.

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Report further studies the market development status and future Animal Stem Cell Therapy Market trend across the world. Also, it splits Animal Stem Cell Therapy market Segmentation by Type and by Applications to fully and deeply research and reveal market profile and prospects.

Major Classifications are as follows:

Geographically,this report is segmented into severalkey regions, with sales, revenue, market share and growth Rate of Animal Stem Cell Therapy in these regions, from 2014 to 2024, covering

This Animal Stem Cell Therapy Market Research/Analysis Report Contains Answers to your following Questions

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Major Points from Table of Contents:

1. Market Overview 1.1 Animal Stem Cell Therapy Introduction 1.2 Market Analysis by Type 1.3 Market Analysis by Applications 1.4 Market Dynamics 1.4.1 Market Opportunities 1.4.2 Market Risk 1.4.3 Market Driving Force

2.Manufacturers Profiles

2.4.1 Business Overview 2.4.2 Animal Stem Cell Therapy Type and Applications 2.4.2.1 Product A 2.4.2.2 Product B

3.Global Animal Stem Cell Therapy Sales, Revenue, Market Share and Competition By Manufacturer (2019-2020)

3.1 Global Animal Stem Cell Therapy Sales and Market Share by Manufacturer (2019-2020) 3.2 Global Animal Stem Cell Therapy Revenue and Market Share by Manufacturer (2019-2020) 3.3 Market Concentration Rates 3.3.1 Top 3 Animal Stem Cell Therapy Manufacturer Market Share in 2020 3.3.2 Top 6 Animal Stem Cell Therapy Manufacturer Market Share in 2020 3.4 Market Competition Trend

4.Global Animal Stem Cell Therapy Market Analysis by Regions

4.1 Global Animal Stem Cell Therapy Sales, Revenue and Market Share by Regions 4.1.1 Global Animal Stem Cell Therapy Sales and Market Share by Regions (2014-2019) 4.1.2 Global Animal Stem Cell Therapy Revenue and Market Share by Regions (2014-2019) 4.2 North America Animal Stem Cell Therapy Sales and Growth Rate (2014-2019) 4.3 Europe Animal Stem Cell Therapy Sales and Growth Rate (2014-2019) 4.4 Asia-Pacific Animal Stem Cell Therapy Sales and Growth Rate (2014-2019) 4.6 South America Animal Stem Cell Therapy Sales and Growth Rate (2014-2019) 4.6 Middle East and Africa Animal Stem Cell Therapy Sales and Growth Rate (2014-2019)

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5.Animal Stem Cell Therapy Market Forecast (2020-2024) 5.1 Global Animal Stem Cell Therapy Sales, Revenue and Growth Rate (2020-2024) 5.2 Animal Stem Cell Therapy Market Forecast by Regions (2020-2024) 5.3 Animal Stem Cell Therapy Market Forecast by Type (2020-2024) 5.3.1 Global Animal Stem Cell Therapy Sales Forecast by Type (2020-2024) 5.3.2 Global Animal Stem Cell Therapy Market Share Forecast by Type (2020-2024) 5.4 Animal Stem Cell Therapy Market Forecast by Application (2020-2024) 5.4.1 Global Animal Stem Cell Therapy Sales Forecast by Application (2020-2024) 5.4.2 Global Animal Stem Cell Therapy Market Share Forecast by Application (2020-2024)

6.Sales Channel, Distributors, Traders and Dealers 6.1 Sales Channel 6.1.1 Direct Marketing 6.1.2 Indirect Marketing 6.1.3 Marketing Channel Future Trend 6.2 Distributors, Traders and Dealers

7.Research Findings and Conclusion

8.Appendix 8.1 Methodology 8.2 Data Source

Continued..

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Stem Cell Trial Tests Treatment for Often-Fatal COVID-19 …

By Jen A. Miller

Researchers are studying whether cells drawn from deep inside our bones may hold hope for the sickest of COVID-19 patients who have severe lung injury called acute respiratory distress syndrome, or ARDS.

The clinical trial, led by Michael Matthay, MD, of UC San Francisco, is testing the effects of infusions of stem cells drawn from bone marrow in the hopes of finding a therapy for the deadly syndrome.

For a patient suffering from ARDS, tiny air spaces in the lungs fill up with fluid and prevent normal oxygen uptake in the lungs, said Michael Matthay, MD, professor of medicine at the UCSF School of Medicine. Thats why the patient has respiratory failure. Usually these patients have to be intubated and treated with a mechanical ventilator.

There is not currently any drug to treat ARDS, which has a mortality rate of 27 percent for mild cases and 45 percent for the most severe cases. An early study on COVID-19 patients with ARDS found that only about 25 percent survive, though that percentage may be as high as 40 percent, according to Matthay.

Patients in a randomized double blind clinical trial are being given mesenchymal stem cells (MSCs) or placebo to test the effectiveness of the therapy. The trial ongoing at UCSF, Zuckerberg San Francisco General Hospital, and soon to expand to UC Davis and four other sites in September hopes to repair the severe and often fatal lung damage in people suffering from ARDS.

Its a very interesting possible therapy, said Matthay. Were really in the early phases of understanding these cell-based therapies.

MSCs are stromal cells found in bone marrow, play a key role in how our bodies make and repair skeletal tissues things like bone and cartilage and support the cells in the bone marrow that produce red and white blood cells. Once researchers discovered that MSCs could modulate inflammation when transplanted into other people, they began exploring them as potential therapies for a range of diseases and traumas.

For example, MSCs are often used to stop graft versus host disease, which is when transplant patients from rejecting new organs or bone marrow. More recent studies have focused on an array of potential disease targets because MSCs have properties that may be useful to treat a variety of human illnesses, said Matthay. Those include autoimmune diseases like Crohns disease and multiple sclerosis, and severe, acute conditions like sepsis and ARDS.

ARDS can be caused by trauma, bacterial infection, or a viral infection like COVID-19. In an earlier trial, Matthay and his team showed that MSCs are be safe to use, and that they have promising benefits in treating patients with ARDS. But they do not know how effective the MSC infusions are, and if results vary depending on what caused ARDS in the first place. Would they work better in a patient whose ARDS was caused by trauma? Or maybe they work better in concert with antibiotics used to treat ARDS that was set off by a bacterial infection.

ARDS is a syndrome of acute respiratory failure that we understand reasonably well, but theres a lot of heterogeneity in terms of the different mechanisms of injury to the lung and also outcomes, he said.

In this Phase 2 double blind clinical trial being funded by the Department of Defense, the National Institutes of Health, and the California Institute of Regenerative Medicine researchers are enrolling 120 ARDS patients. Enrollees are adult ICU patients who are on ventilators with excess fluid in their lungs, and no sign of heart failure as a primary cause of the respiratory failure.

Half of the patients will receive MSCs and half a placebo. As of late August, 28 patients were enrolled in the study, which will run until researchers reach 120 enrollees. The MSCs used in the study have been donated by young, healthy adults via an NIH-supported cell laboratory at the University of Minnesota.

When Matthay launched a new study in early January, he didnt expect it be a COVID trial. Thats because COVID as far as was known then wasnt in the U.S. But thats exactly what it inadvertently became since many patients who met the ARDS study criteria were suffering the condition because of COVID-19.

We started the study in January 2020, and then COVID-19 hit, so we have been enrolling patients over the last eight months, he said. Most of the patients weve enrolled in the trial have ended up having severe viral pneumonia from COVID.

Based on these outcomes and further studies on MSCs, Matthay sees them as a possible route for cell-based therapy. Much like cancer treatment isnt one approach but instead different therapies tailored to the type of cancer cells, use of something like MSCs could be perhaps tailored exactly to whatever specific kind of syndrome of respiratory failure.

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Stem Cell Trial Tests Treatment for Often-Fatal COVID-19 ...

Allogeneic Hematopoietic Stem Cell Transplant Effective for Patients with CLL Previously Treated with Novel Agents – Curetoday.com

Novel agents are becoming an important part of the chronic lymphocytic leukemia landscape as they improve outcomes for patients, but the number of novel agents used prior to allogeneic hematopoietic stem cell transplant (alloHCT) and after do not have an impact on survival outcomes.

AlloHCT was the standard of care for patients with early relapse or refractory chronic lymphocytic leukemia (CLL) and provided an opportunity for long-term disease control in the absence of other treatments. Now, novel agents such as Imbruvica (ibrutinib), Calquence (acalabrutinib) and Venclexta (venetoclax) are improving response rates, progression-free survival (PFS) and overall survival (OS) in patients and paving the way for long-term disease control depending on sequential treatment. Moreover, these novel agents dont come with the same risks as alloHCT such as graft-versus-host-disease (GVHD), organ toxicity and non-relapse mortality (NRM).

However, some patients still face initial barriers with these novel agents and all of the novel agents may not work for them, but researchers have determined that alloHCT remains an option for these patients and is not adversely impacted by novel agents. In a study of 65 patients with CLL who underwent one or more treatments with novel agents, whether prior to alloHCT or after, researchers found a two-year PFS of 63%, OS of 81%, NRM of 13% and relapse incidence of 27%. Moderate to severe GVHD developed in 27% of patients.

The data presented here support consideration of alloHCT for novel agents treated, fit patients, with responding disease, the authors wrote, and should be considered particularly for patients in whom novel agents are not expected to provide long-term disease control.

Ninety-two percent of patients received novel agent immediately prior to alloHCT treatment with a 6% complete response for those receiving Imbruvica, 97% of patients then discontinued it before alloHCT treatment. Patients receiving Venclexta-based therapy prior to alloHCT had a 52% complete response and 95% discontinued treatment prior to alloHCT with intolerance of the therapy in 5%.

After alloHCT treatment, researchers looked at patients in two arms, those who were exposed to one novel agent versus two or more novel agents with similar poor risk features and a similar median age of 60. Both groups had similar PFS and OS outcomes that were not significantly different and that exposure to these novel agents prior to alloHCT were also predictors of PFS after alloHCT treatment with no significant differences between the arms. The predicated outcomes were initially estimated at 66% PFS and 94% OS. Those results suggest that alloHCT is still a meaningful treatment even when patients with CLL are exposed to novel agents, the authors explained.

Taken together, this study suggests that alloHCT is safe and effective in patients with CLL exposed to one or more novel agents prior to alloHCT, they concluded. These data support the use of alloHCT for well-selected patients with high-risk CLL.

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Allogeneic Hematopoietic Stem Cell Transplant Effective for Patients with CLL Previously Treated with Novel Agents - Curetoday.com