Reduce variation with the most complete, defined system for human embryonic stem cell (ES cell) and induced pluripotent stem cell (iPS cell) culture featuring mTeSR1 and the TeSR media family. From generation of iPS cells to maintenance, differentiation, characterization and cryopreservation of ES and iPS cells, see how you can "Maximize Your Pluripotential".

A Complete System for Supporting Your Human Pluripotent Stem Cell Research Human pluripotent stem cell (hPSC) research is an expanding field that has potential to change the way human diseases are studied and treated. The ability to differentiate ES cells and iPS cells to specific downstream cell types opens up new avenues for drug development and regenerative medicine.

STEMCELL Technologies offers an array of products designed to support the various steps of your ES and iPS cell culture workflow, from isolation, reprogramming and expansion to directed differentiation and characterization. For help with your hPSC workflow decision making, use ourinfographicsto find the right reagents for you.

Small Molecules for Reprogramming iPS cells have been traditionally generated through exogenous expression of pluripotency genes (via viral or episomal vectors). However, small molecules are increasingly being utilized and have been demonstrated to increase reprogramming efficiency:

Small Molecules for Maintenance Maintenance of stem cells in defined culture systems can reduce experimental variability. Small molecules have been used to stimulate the self-renewal capabilities of ES and iPS cells or increase viability of single cells.

TeSR-E5 and TeSR-E6 are defined, serum- and xeno-free media that are based on the formulation of TeSR-E8, but do not contain transforming growth factor (TGF-), basic fibroblast growth factor (bFGF), or in the case of TeSR-E5, insulin. They may be used as basal media for differentiation of human ES or iPS cells or other applications where removal of the above cytokines and insulin is desirable. To learn more about the functions of the different cytokines in the TeSR media, click here.

Small Molecules for Differentiation Differentiation of pluripotent stem cells to specialized cell types requires selective activation or inhibition of specific signaling pathways. Small molecules have been used to identify pathways required for differentiation, and are often used in place of expensive growth factors to direct differentiation.

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Embryonic Stem Cell Maintenance & Differentiation (Human)