Sakaguchi, A. & Kimura, W. Metabolic regulation of cardiac regeneration: Roles of hypoxia, energy homeostasis, and mitochondrial dynamics. Curr. Opin. Genet. Dev. 70, 5460 (2021).

Article CAS PubMed Google Scholar

Mohammadi Nasr, S. et al. Biodegradable nanopolymers in cardiac tissue engineering: From concept towards nanomedicine. IJN 15, 42054224 (2020).

Article PubMed PubMed Central Google Scholar

He, L. & Chen, X. Cardiomyocyte induction and regeneration for myocardial infarction treatment: Cell sources and administration strategies. Adv. Healthc. Mater. 9, 2001175 (2020).

Article CAS Google Scholar

Lu, T.-Y., Xiang, Y., Tang, M. & Chen, S. 3D printing approaches to engineer cardiac tissue. Curr. Cardiol. Rep. 25, 505514 (2023).

Article PubMed PubMed Central Google Scholar

Lu, B. et al. Electrical stimulation promotes the vascularization and functionalization of an engineered biomimetic human cardiac tissue. Adv. Healthc. Mater 12, 2300607 (2023).

Article CAS Google Scholar

Abdolahzadeh, H. et al. Progress and promise of cell sheet assisted cardiac tissue engineering in regenerative medicine. Biomed. Mater. 18, 032001 (2023).

Article ADS Google Scholar

Lian, X., Zhang, J., Zhu, K., Kamp, T. J. & Palecek, S. P. Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical Wnt signaling can rescue this inhibition. Stem Cells 31, 447457 (2013).

Article CAS PubMed Google Scholar

Lian, X. et al. Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/-catenin signaling under fully defined conditions. Nat. Protoc. 8, 162175 (2013).

Article CAS PubMed Google Scholar

Vukovi, S. et al. Characterization of cardiac metabolism in iPSC-derived cardiomyocytes: Lessons from maturation and disease modeling. Stem Cell Res. Ther. 13, 332 (2022).

Article PubMed PubMed Central Google Scholar

Karbassi, E. et al. Cardiomyocyte maturation: Advances in knowledge and implications for regenerative medicine. Nat. Rev. Cardiol. 17, 341359 (2020).

Article PubMed PubMed Central Google Scholar

Parikh, S. S. et al. Thyroid and glucocorticoid hormones promote functional t-tubule development in human-induced pluripotent stem cell-derived cardiomyocytes. Circ. Res. 121, 13231330 (2017).

Article CAS PubMed PubMed Central Google Scholar

Goversen, B., Van Der Heyden, M. A. G., Van Veen, T. A. B. & De Boer, T. P. The immature electrophysiological phenotype of iPSC-CMs still hampers in vitro drug screening: Special focus on I K1. Pharmacol. Ther. 183, 127136 (2018).

Article CAS PubMed Google Scholar

Xu, Y., Xiao, M., Li, X. & Jiang, Z. Regulatory effect of anisotropic structure on cardiomyocyte maturation. STEMedicine 4, e179 (2023).

Article Google Scholar

Ding, M. et al. Aligned nanofiber scaffolds improve functionality of cardiomyocytes differentiated from human induced pluripotent stem cell-derived cardiac progenitor cells. Sci. Rep. 10, 13575 (2020).

Article ADS CAS PubMed PubMed Central Google Scholar

Wu, P. et al. Maturation strategies and limitations of induced pluripotent stem cell-derived cardiomyocytes. Biosci. Rep. 41, BSR20200833 (2021).

Article CAS PubMed PubMed Central Google Scholar

Li, H., Bao, M. & Nie, Y. Extracellular matrixbased biomaterials for cardiac regeneration and repair. Heart Fail. Rev. 26, 12311248 (2021).

Article PubMed Google Scholar

Lutter, G. et al. Biodegradable poly--caprolactone Scaffolds with ECFCs and iMSCs for tissue-engineered heart valves. IJMS 23, 527 (2022).

Article CAS PubMed PubMed Central Google Scholar

Tomecka, E. et al. Poly( l -lactic acid) and polyurethane nanofibers fabricated by solution blow spinning as potential substrates for cardiac cell culture. Mater. Sci. Eng. C 75, 305316 (2017).

Article CAS Google Scholar

Karimi, S. N. H., Aghdam, R. M., Ebrahimi, S. A. S. & Chehrehsaz, Y. Tri-layered alginate/poly( -caprolactone) electrospun scaffold for cardiac tissue engineering. Polym. Int. 71, 10991108 (2022).

Article CAS Google Scholar

Ahmadi, P., Nazeri, N., Derakhshan, M. A. & Ghanbari, H. Preparation and characterization of polyurethane/chitosan/CNT nanofibrous scaffold for cardiac tissue engineering. Int. J. Biol. Macromol. 180, 590598 (2021).

Article CAS PubMed Google Scholar

Fakhrali, A. et al. Biocompatible graphene-embedded PCL/PGS -based nanofibrous scaffolds: A potential application for cardiac tissue regeneration. J. Appl. Polym. Sci. 138, 51177 (2021).

Article CAS Google Scholar

Homaeigohar, S. & Boccaccini, A. R. Nature-derived and synthetic additives to poly(-caprolactone) nanofibrous systems for biomedicine; an updated overview. Front. Chem. 9, 809676 (2022).

Article PubMed PubMed Central Google Scholar

Jirofti, N., Mohebbi-Kalhori, D., Samimi, A., Hadjizadeh, A. & Kazemzadeh, G. H. Small-diameter vascular graft using co-electrospun composite PCL/PU nanofibers. Biomed. Mater. 13, 055014 (2018).

Article ADS PubMed Google Scholar

Janmohammadi, M. & Nourbakhsh, M. S. Electrospun polycaprolactone scaffolds for tissue engineering: A review. Int. J. Polym. Mater. Polym. Biomater. 68, 527539 (2019).

Article CAS Google Scholar

Khan, M. et al. Evaluation of changes in morphology and function of human induced pluripotent stem cell derived cardiomyocytes (HiPSC-CMs) cultured on an aligned-nanofiber cardiac patch. PLoS One 10, e0126338 (2015).

Article PubMed PubMed Central Google Scholar

Dos Santos, D. M., Correa, D. S., Medeiros, E. S., Oliveira, J. E. & Mattoso, L. H. C. Advances in functional polymer nanofibers: From spinning fabrication techniques to recent biomedical applications. ACS Appl. Mater. Interfaces 12, 4567345701 (2020).

Article PubMed Google Scholar

Dadol, G. C. et al. Solution blow spinning (SBS) and SBS-spun nanofibers: Materials, methods, and applications. Mater. Today Commun. 25, 101656 (2020).

Article CAS Google Scholar

Wojasiski, M., Pilarek, M. & Ciach, T. Comparative studies of electrospinning and solution blow spinning processes for the production of nanofibrous poly(L-lactic acid) materials for biomedical engineering. Pol. J. Chem. Technol. 16, 4350 (2014).

Article Google Scholar

Keshvardoostchokami, M. et al. Electrospun nanofibers of natural and synthetic polymers as artificial extracellular matrix for tissue engineering. Nanomaterials 11, 21 (2020).

Article PubMed PubMed Central Google Scholar

Karkan, S. F., Davaran, S., Rahbarghazi, R., Salehi, R. & Akbarzadeh, A. Electrospun nanofibers for the fabrication of engineered vascular grafts. J. Biol. Eng. 13, 83 (2019).

Article PubMed PubMed Central Google Scholar

Hong, Y. et al. Engineering the maturation of stem cell-derived cardiomyocytes. Front. Bioeng. Biotechnol. 11, 1155052 (2023).

Article PubMed PubMed Central Google Scholar

Scuderi, G. J. & Butcher, J. Naturally engineered maturation of cardiomyocytes. Front. Cell Dev. Biol. 5, 50 (2017).

Article PubMed PubMed Central Google Scholar

Gorecka, J. et al. The potential and limitations of induced pluripotent stem cells to achieve wound healing. Stem Cell Res. Ther. 10, 87 (2019).

Article CAS PubMed PubMed Central Google Scholar

Li, J., Feng, X. & Wei, X. Modeling hypertrophic cardiomyopathy with human cardiomyocytes derived from induced pluripotent stem cells. Stem Cell Res. Ther. 13, 232 (2022).

Article CAS PubMed PubMed Central Google Scholar

Lewis-Israeli, Y. R. et al. Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease. Nat. Commun. 12, 5142 (2021).

Article ADS CAS PubMed PubMed Central Google Scholar

Tan, Y. et al. Engineering a conduction-consistent cardiac patch with rGO/PLCL electrospun nanofibrous membranes and human iPSC-derived cardiomyocytes. Front. Bioeng. Biotechnol. 11, 1094397 (2023).

Article PubMed PubMed Central Google Scholar

Tian, F. et al. Aligned nanofibrous net deposited perpendicularly on microridges supports endothelium formation and promotes the structural maturation of hiPSC-derived cardiomyocytes. ACS Appl. Mater. Interfaces 15, 1751817531 (2023).

Article CAS PubMed Google Scholar

Chen, Y., Chan, J. P. Y., Wu, J., Li, R. & Santerre, J. P. Compatibility and function of human induced pluripotent stem cell derived cardiomyocytes on an electrospun nanofibrous scaffold, generated from an ionomeric polyurethane composite. J. Biomed. Mater. Res 110, 19321943 (2022).

Article CAS Google Scholar

Liu, L. et al. Integrated manufacturing of suspended and aligned nanofibrous scaffold for structural maturation and synchronous contraction of HiPSC-derived cardiomyocytes. Bioengineering 10, 702 (2023).

Article CAS PubMed PubMed Central Google Scholar

Hashida, A. et al. Effect of morphological change on the maturation of human induced pluripotent stem cell-derived cardiac tissue in rotating flow culture. Regen. Ther 24, 479488 (2023).

Article CAS PubMed PubMed Central Google Scholar

Kitsara, M., Agbulut, O., Kontziampasis, D., Chen, Y. & Menasch, P. Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering. Acta Biomater. 48, 2040 (2017).

Article CAS PubMed Google Scholar

Kai, D., Prabhakaran, M. P., Jin, G. & Ramakrishna, S. Guided orientation of cardiomyocytes on electrospun aligned nanofibers for cardiac tissue engineering. J. Biomed. Mater. Res. 98B, 379386 (2011).

Article CAS Google Scholar

Gao, Y. et al. Recent progress and challenges in solution blow spinning. Mater. Horiz. 8, 426446 (2021).

Article ADS CAS PubMed Google Scholar

Querdel, E. et al. Human engineered heart tissue patches remuscularize the injured heart in a dose-dependent manner. Circulation 143, 19912006 (2021).

Article CAS PubMed PubMed Central Google Scholar

Li, J. et al. Human pluripotent stem cell-derived cardiac tissue-like constructs for repairing the infarcted myocardium. Stem Cell Rep. 9, 15461559 (2017).

Article ADS CAS Google Scholar

Li, J. et al. Developing thick cardiac tissue with a multilayer fiber sheet for treating myocardial infarction. Adv. Fiber Mater. 5, 19051918 (2023).

Article CAS Google Scholar

Guo, Y. & Pu, W. T. Cardiomyocyte maturation: New phase in development. Circ. Res. 126, 10861106 (2020).

Article CAS PubMed PubMed Central Google Scholar

Eom, S. et al. Fabrication of an align-random distinct, heterogeneous nanofiber mat endowed with bifunctional properties for engineered 3D cardiac anisotropy. Compos. B Eng. 226, 109336 (2021).

Article Google Scholar

Li, D. et al. Fabrication of multilayered nanofiber scaffolds with a highly aligned nanofiber yarn for anisotropic tissue regeneration. ACS Omega 5, 2434024350 (2020).

Article CAS PubMed PubMed Central Google Scholar

Kolanowski, T. J., Antos, C. L. & Guan, K. Making human cardiomyocytes up to date: Derivation, maturation state and perspectives. Int. J. Cardiol. 241, 379386 (2017).

Article PubMed Google Scholar

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