The Global Cell Expansion Market is expected to grow from USD 11,923.12 Million in 2018 to USD 30,023.12 Million by the end of 2025 at a Compound…

The positioning of the Global Cell Expansion Market vendors in FPNV Positioning Matrix are determined by Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) and placed into four quadrants (F: Forefront, P: Pathfinders, N: Niche, and V: Vital).

New York, March 25, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Global Cell Expansion Market - Premium Insight, Competitive News Feed Analysis, Company Usability Profiles, Market Sizing & Forecasts to 2025" - https://www.reportlinker.com/p05872140/?utm_source=GNW

The report deeply explores the recent significant developments by the leading vendors and innovation profiles in the Global Cell Expansion Market including are Beckman Coulter Inc., Becton, Dickinson and Company, Merck KGaA, Terumo BCT, Thermo Fisher Scientific, Inc., Corning Incorporated, GE Healthcare, Lonza Group LTD., Miltenyi Biotec, Promocell GmbH, Sartorius AG, Stemcell Technologies, Inc., and Takara Bio Inc..

On the basis of Product, the Global Cell Expansion Market is studied across Consumables and Instruments.

On the basis of Cell Type, the Global Cell Expansion Market is studied across Animal Cells and Human Cells.

On the basis of Application, the Global Cell Expansion Market is studied across Cancer and Cell-Based Research and Regenerative Medicine and Stem Cell Research.

On the basis of End User, the Global Cell Expansion Market is studied across Biotechnology & Biopharmaceutical Companies, Cell Banks, and Research Institutes.

For the detailed coverage of the study, the market has been geographically divided into the Americas, Asia-Pacific, and Europe, Middle East & Africa. The report provides details of qualitative and quantitative insights about the major countries in the region and taps the major regional developments in detail.

In the report, we have covered two proprietary models, the FPNV Positioning Matrix and Competitive Strategic Window. The FPNV Positioning Matrix analyses the competitive market place for the players in terms of product satisfaction and business strategy they adopt to sustain in the market. The Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies. The Competitive Strategic Window helps the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. During a forecast period, it defines the optimal or favorable fit for the vendors to adopt successive merger and acquisitions strategies, geography expansion, research & development, new product introduction strategies to execute further business expansion and growth.

Research Methodology:Our market forecasting is based on a market model derived from market connectivity, dynamics, and identified influential factors around which assumptions about the market are made. These assumptions are enlightened by fact-bases, put by primary and secondary research instruments, regressive analysis and an extensive connect with industry people. Market forecasting derived from in-depth understanding attained from future market spending patterns provides quantified insight to support your decision-making process. The interview is recorded, and the information gathered in put on the drawing board with the information collected through secondary research.

The report provides insights on the following pointers:1. Market Penetration: Provides comprehensive information on sulfuric acid offered by the key players in the Global Cell Expansion Market 2. Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and new product developments in the Global Cell Expansion Market 3. Market Development: Provides in-depth information about lucrative emerging markets and analyzes the markets for the Global Cell Expansion Market 4. Market Diversification: Provides detailed information about new products launches, untapped geographies, recent developments, and investments in the Global Cell Expansion Market 5. Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, and manufacturing capabilities of the leading players in the Global Cell Expansion Market

The report answers questions such as:1. What is the market size of Cell Expansion market in the Global?2. What are the factors that affect the growth in the Global Cell Expansion Market over the forecast period?3. What is the competitive position in the Global Cell Expansion Market?4. Which are the best product areas to be invested in over the forecast period in the Global Cell Expansion Market?5. What are the opportunities in the Global Cell Expansion Market?6. What are the modes of entering the Global Cell Expansion Market?Read the full report: https://www.reportlinker.com/p05872140/?utm_source=GNW

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The Global Cell Expansion Market is expected to grow from USD 11,923.12 Million in 2018 to USD 30,023.12 Million by the end of 2025 at a Compound...

Autologous Stem Cell and Non-Stem Cell Based Therapies Market Research Key Players, Industry Overview and Forecasts to 2027 – Packaging News 24

The Global Autologous Stem Cell and Non-Stem Cell Based Therapies Market Analysis to 2027 is a specialized and in-depth study of the medical device industry with a special focus on the global market trend analysis. The report aims to provide an overview of Autologous Stem Cell and Non-Stem Cell Based Therapies market with detailed market segmentation by application, end user, and geography. The global Autologous Stem Cell and Non-Stem Cell Based Therapies market is expected to witness high growth during the forecast period. The report provides key statistics on the market status of the leading Autologous Stem Cell and Non-Stem Cell Based Therapies market players and offers key trends and opportunities in the market.

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The key players influencing the market are:

This report contains:

Autologous Stem Cell and Non-Stem Cell Based Therapies Market report also provide a in-depth understanding of the cutting-edge competitive analysis of the emerging market trends along with the drivers, restraints, and opportunities in the market to offer worthwhile insights and current scenario for making right decision. The report covers the prominent players in the market with detailed SWOT analysis, financial overview, and key developments of last three years. Moreover, the report also offers a 360 outlook of the market through the competitive landscape of the global industry player and helps the companies to garner Autologous Stem Cell and Non-Stem Cell Based Therapies Market revenue by understanding the strategic growth approaches.

Autologous Stem Cell and Non-Stem Cell Based Therapies Market is a combination of qualitative as well as quantitative analysis which can be broken down into 40% and 60% respectively. Market estimation and forecasts are presented in the report for the overall global market from 2020 2027, considering 2020 as the base year and 2020 2027 forecast period. Global estimation is further broken down by segments and geographies such as North America, Europe, Asia-Pacific, Middle East & Africa and South America covering major 16 countries across the mentioned regions. The qualitative contents for geographical analysis will cover market trends in each region and country which includes highlights of the key players operating in the respective region/country, PEST analysis of each region which includes political, economic, social and technological factors influencing the growth of the market.

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Autologous Stem Cell and Non-Stem Cell Based Therapies Market Research Key Players, Industry Overview and Forecasts to 2027 - Packaging News 24

Global Cell Culture Market Industry Analysis and Forecast (2019-2026) – Stock Market Herald

Global Cell Culture Market was valued US$ XX Bn in 2018 and is expected to reach US$ XX Bn by 2026, at CAGR of 12% during forecast period.

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Utilization of cell cultures has improved to an extent where old small-scale production and handling of cultures decreasing for the growing demand. This has stimulated the development of automatic large-scale cell culture systems which are proficient of creating high throughput cell cultures of exceptional purity and in larger quantities. Continued development of cell culture methods and applications has poised this market to anticipate a steady and substantial growth by to 2026.

Because of the revolutions in genetic engineering there has been a major increase in the usage of protein based biopharmaceuticals. Their invention is greatly dependent on the protein expression systems resultant from mammalian cell cultures and production of high yielding cell lines. This newly developed application of cell cultures in the biopharmaceutical is responsible for most of the revenue generated from this segment and is also estimated to be the main cause for the same during the forecast period.

Largest share of revenue produced worldwide was accounted for by North America in 2017. Because of the introduction and progress of automated cell culture techniques and increasing usage of stem cell therapy in the region, cell culture finds maximum application in U.S. and Canadian life science laboratories. In U.S. alone, cell culture mechanization for cell-based assays like induced pluripotent stem cell research, cellular expression, culturing of monoclonal antibodies (MaBs) and cryobanking accounted for around a third of the income generated.

As a result of unconventional developments in bioreactors, companies are also contained in the summary and improvement of 3D cell culture methods which are a step up from the predictable 2D cell cultures. Three-dimensional cell collections which are acquired from 3D cultures are more accurate models of in vivo cells and it is projected that there expansion will further boost the market growth.

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The objective of the report is to present a comprehensive assessment of the market and contains thoughtful insights, facts, historical data, industry-validated market data and projections with a suitable set of assumptions and methodology. The report also helps in understanding Cell Culture Market dynamics, structure by identifying and analyzing the market segments and project the global market size. Further, the report also focuses on the competitive analysis of key players by product, price, financial position, product portfolio, growth strategies, and regional presence. The report also provides PEST analysis, PORTERs analysis, and SWOT analysis to address the question of shareholders to prioritizing the efforts and investment in the near future to the emerging segment in Cell Culture Market.Scope of Global Cell Culture Market:

Global Cell Culture Market by Product:

Consumables EquipmentGlobal Cell Culture Market by Application:

Stem Cell Vaccines Therapeutic proteinsGlobal Cell Culture Market by End User:

Pharma Research InstitutesGlobal Cell Culture Market by Region:

North America Asia Pacific Europe Middle East & Africa South AfricaKey Players Operating in the market includes:

Becton Dickinson and Company Thermo Fisher Scientific Merck KGaA HiMedia Laboratories GE Healthcare Lonza Corning Incorporated Sartorius AG Eppendorf AG PromoCell GmbH Danaher Corporation Irvine Scientific InvivoGen CellGenix GmbH

MAJOR TOC OF THE REPORT

Chapter One: Cell Culture Market Overview

Chapter Two: Manufacturers Profiles

Chapter Three: Global Cell Culture Market Competition, by Players

Chapter Four: Global Cell Culture Market Size by Regions

Chapter Five: North America Cell Culture Revenue by Countries

Chapter Six: Europe Cell Culture Revenue by Countries

Chapter Seven: Asia-Pacific Cell Culture Revenue by Countries

Chapter Eight: South America Cell Culture Revenue by Countries

Chapter Nine: Middle East and Africa Revenue Cell Culture by Countries

Chapter Ten: Global Cell Culture Market Segment by Type

Chapter Eleven: Global Cell Culture Market Segment by Application

Chapter Twelve: Global Cell Culture Market Size Forecast (2019-2026)

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Global Cell Culture Market Industry Analysis and Forecast (2019-2026) - Stock Market Herald

Scientists ‘Reset’ The Age of Stem Cells From a Supercentenarian Who Lived to 114 – ScienceAlert

For the first time, scientists have reprogrammed the stem cells of a 114-year-old woman, the oldest donor to date.

After first transforming cells from her blood sample into induced pluripotent stem cells (iPSCs), the researchers then generated mesenchymal stem cells, which help to maintain and repair tissues like bone, cartilage and fat.

"We set out to answer a big question: Can you reprogram cells this old?" says stem cell biologist Evan Snyder at Sanford Burnham Prebys Medical Discovery Institute in California.

"Now we have shown it can be done, and we have a valuable tool for finding the genes and other factors that slow down the aging process."

Stem cells are sometimes called "cellular Rosetta stones", because they allow us to study disease, cancer, ageing and regeneration like never before.

The most valuable type are embryonic stem cells (ESCs), but their acquisition is linked to some ethical issues, and such cells can be difficult to get a hold of. Thankfully, somatic cells, or adult stem cells, can be found in any human; we have the technology to genetically reprogram these units into induced pluripotent stem cells, which are nearly as potent as ESCs.

Until now, however, we weren't sure just how long an adult's cells remain programmable in this way. While some previous research suggests older stem cells cannot be reprogrammed, in recent years, scientists have been able to generate iPSCs from centenarians, or people who live to be more than 100 years old.

So, what about those who've won an even bigger genetic lottery? What about supercentenarians?

In the whole wide world, currently we know of only 28 people verified to be over the age of 110. This unique population is difficult to study, not only because of its limited sample size but also because of our records, which can be pretty shoddy at times.

Nevertheless, research so far has found supercentenarians not only age slower, they also show a strange immunity in general to chronic age-related diseases, like Alzheimer's and Parkinson's, that doesn't seem to have a lot to do with lifestyle.

"Why do supercentenarians age so slowly?" says Snyder. "We are now set to answer that question in a way no one has been able to before."

To do this, the team reprogrammed lymphoblastsfrom three donors: the supercentenarian woman, a healthy 43-year-old individual, and an 8-year-old child with a condition that causes rapid ageing.

Not only did the supercentenarian cells transform into iPSCs just as easily as the others, the telomeres - sequences of 'protective' DNA that sit at the ends of our chromosomes and shrink as we age - were also reset to more "youthful levels".

Granted, this telomere resetting didn't occur as frequently in older cells, only a third of the time. Nevertheless, the authors say what they were able to achieve on these occasions was equivalent to turning back the cellular clock from age 114 to age zero.

"These data indicate that extreme age is not an absolute barrier to reprogramming with restoration of telomere length," the authors write.

What's more, their technique only required four reprogramming factors - a manageable number that will make it relatively easy for scientists to see how these supercentenarian stem cells compare in the long run.

They claim reprogramming donor cells from extremely or prematurely aged donors is feasible, and that by doing so with retrospective samples, we might be able to expand on this small pool of supercentenarian donors.

The authors of the study hope their research will allow us to better investigate how and why supercentenarians live so long and are so extraordinarily resistant to degenerative disease. There's much we can learn from these remarkable people.

The study was published in Biochemical and Biophysical Research Communications.

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Scientists 'Reset' The Age of Stem Cells From a Supercentenarian Who Lived to 114 - ScienceAlert

The Global Cell Culture Market is expected to grow from USD 14,923.23 Million in 2018 to USD 35,236.23 Million by the end of 2025 at a Compound Annual…

The positioning of the Global Cell Culture Market vendors in FPNV Positioning Matrix are determined by Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) and placed into four quadrants (F: Forefront, P: Pathfinders, N: Niche, and V: Vital).

New York, March 25, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Global Cell Culture Market - Premium Insight, Competitive News Feed Analysis, Company Usability Profiles, Market Sizing & Forecasts to 2025" - https://www.reportlinker.com/p05872141/?utm_source=GNW

The report deeply explores the recent significant developments by the leading vendors and innovation profiles in the Global Cell Culture Market including are Becton, Dickinson and Company, Cellgenix, Corning, Danaher, Eppendorf, Fujifilm Irvine Scientific, GE Healthcare, Hi-Media Laboratories, Invivogen, Lonza Group AG, Merck KGaA, Miltenyi Biotec, Promocell, and Sartorius AG.

On the basis of Product, the Global Cell Culture Market is studied across Consumables and Equipment.

On the basis of Application , the Global Cell Culture Market is studied across Biopharmaceutical Production, Diagnostics, Drug Screening and Development, Stem Cell Research, and Tissue Engineering & Regenerative Medicine.

On the basis of End User , the Global Cell Culture Market is studied across Cell Banks, Hospitals and Diagnostic Laboratories, Pharmaceutical & Biotechnology Companies, and Research Institutes.

For the detailed coverage of the study, the market has been geographically divided into the Americas, Asia-Pacific, and Europe, Middle East & Africa. The report provides details of qualitative and quantitative insights about the major countries in the region and taps the major regional developments in detail.

In the report, we have covered two proprietary models, the FPNV Positioning Matrix and Competitive Strategic Window. The FPNV Positioning Matrix analyses the competitive market place for the players in terms of product satisfaction and business strategy they adopt to sustain in the market. The Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies. The Competitive Strategic Window helps the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. During a forecast period, it defines the optimal or favorable fit for the vendors to adopt successive merger and acquisitions strategies, geography expansion, research & development, new product introduction strategies to execute further business expansion and growth.

Research Methodology:Our market forecasting is based on a market model derived from market connectivity, dynamics, and identified influential factors around which assumptions about the market are made. These assumptions are enlightened by fact-bases, put by primary and secondary research instruments, regressive analysis and an extensive connect with industry people. Market forecasting derived from in-depth understanding attained from future market spending patterns provides quantified insight to support your decision-making process. The interview is recorded, and the information gathered in put on the drawing board with the information collected through secondary research.

The report provides insights on the following pointers:1. Market Penetration: Provides comprehensive information on sulfuric acid offered by the key players in the Global Cell Culture Market 2. Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and new product developments in the Global Cell Culture Market 3. Market Development: Provides in-depth information about lucrative emerging markets and analyzes the markets for the Global Cell Culture Market 4. Market Diversification: Provides detailed information about new products launches, untapped geographies, recent developments, and investments in the Global Cell Culture Market 5. Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, and manufacturing capabilities of the leading players in the Global Cell Culture Market

The report answers questions such as:1. What is the market size of Cell Culture market in the Global?2. What are the factors that affect the growth in the Global Cell Culture Market over the forecast period?3. What is the competitive position in the Global Cell Culture Market?4. Which are the best product areas to be invested in over the forecast period in the Global Cell Culture Market?5. What are the opportunities in the Global Cell Culture Market?6. What are the modes of entering the Global Cell Culture Market?Read the full report: https://www.reportlinker.com/p05872141/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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The Global Cell Culture Market is expected to grow from USD 14,923.23 Million in 2018 to USD 35,236.23 Million by the end of 2025 at a Compound Annual...

The Global Cell Isolation/Cell Separation Market is expected to grow from USD 5,721.23 Million in 2018 to USD 15,089.25 Million by the end of 2025 at…

New York, March 25, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Global Cell Isolation/Cell Separation Market - Premium Insight, Competitive News Feed Analysis, Company Usability Profiles, Market Sizing & Forecasts to 2025" - https://www.reportlinker.com/p05872137/?utm_source=GNW

The report deeply explores the recent significant developments by the leading vendors and innovation profiles in the Global Cell Isolation/Cell Separation Market including are Beckman Coulter Inc. (Subsidiary of Danaher Corporation), Becton, Dickinson and Company, Merck KGaA, Terumo Bct, Thermo Fisher Scientific, Inc., Bio-Rad Laboratories, Inc., GE Healthcare, Miltenyi Biotec, Pluriselect Life Science Ug (Haftungsbeschrnkt) & Co. Kg, and Stemcell Technologies, Inc..

On the basis of Product, the Global Cell Isolation/Cell Separation Market is studied across Consumables and Instruments.

On the basis of Cell Type, the Global Cell Isolation/Cell Separation Market is studied across Animal Cells and Human Cells.

On the basis of Cell Source, the Global Cell Isolation/Cell Separation Market is studied across Adipose Tissue, Bone Marrow, and Cord Blood/Embryonic Stem Cells.

On the basis of Technique, the Global Cell Isolation/Cell Separation Market is studied across Centrifugation-Based Cell Isolation, Filtration-Based Cell Isolation, and Surface Marker-Based Cell Isolation.

On the basis of Application, the Global Cell Isolation/Cell Separation Market is studied across Biomolecule Isolation, Cancer Research, In Vitro Diagnostics, Stem Cell Research, and Tissue Regeneration & Regenerative Medicine.

On the basis of End User, the Global Cell Isolation/Cell Separation Market is studied across Biotechnology & Biopharmaceutical Companies, Hospitals & Diagnostic Laboratories, and Research Laboratories & Institutes.

For the detailed coverage of the study, the market has been geographically divided into the Americas, Asia-Pacific, and Europe, Middle East & Africa. The report provides details of qualitative and quantitative insights about the major countries in the region and taps the major regional developments in detail.

In the report, we have covered two proprietary models, the FPNV Positioning Matrix and Competitive Strategic Window. The FPNV Positioning Matrix analyses the competitive market place for the players in terms of product satisfaction and business strategy they adopt to sustain in the market. The Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies. The Competitive Strategic Window helps the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. During a forecast period, it defines the optimal or favorable fit for the vendors to adopt successive merger and acquisitions strategies, geography expansion, research & development, new product introduction strategies to execute further business expansion and growth.

Research Methodology:Our market forecasting is based on a market model derived from market connectivity, dynamics, and identified influential factors around which assumptions about the market are made. These assumptions are enlightened by fact-bases, put by primary and secondary research instruments, regressive analysis and an extensive connect with industry people. Market forecasting derived from in-depth understanding attained from future market spending patterns provides quantified insight to support your decision-making process. The interview is recorded, and the information gathered in put on the drawing board with the information collected through secondary research.

The report provides insights on the following pointers:1. Market Penetration: Provides comprehensive information on sulfuric acid offered by the key players in the Global Cell Isolation/Cell Separation Market 2. Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and new product developments in the Global Cell Isolation/Cell Separation Market 3. Market Development: Provides in-depth information about lucrative emerging markets and analyzes the markets for the Global Cell Isolation/Cell Separation Market 4. Market Diversification: Provides detailed information about new products launches, untapped geographies, recent developments, and investments in the Global Cell Isolation/Cell Separation Market 5. Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, and manufacturing capabilities of the leading players in the Global Cell Isolation/Cell Separation Market

The report answers questions such as:1. What is the market size of Cell Isolation/Cell Separation market in the Global?2. What are the factors that affect the growth in the Global Cell Isolation/Cell Separation Market over the forecast period?3. What is the competitive position in the Global Cell Isolation/Cell Separation Market?4. Which are the best product areas to be invested in over the forecast period in the Global Cell Isolation/Cell Separation Market?5. What are the opportunities in the Global Cell Isolation/Cell Separation Market?6. What are the modes of entering the Global Cell Isolation/Cell Separation Market?Read the full report: https://www.reportlinker.com/p05872137/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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The Global Cell Isolation/Cell Separation Market is expected to grow from USD 5,721.23 Million in 2018 to USD 15,089.25 Million by the end of 2025 at...

How Crucial is the Cellular Communications Between the Detached Cancerous Cells and Fibroblast for Growing Metastasis – Spark Health MD

Researchers from the German Cancer Research Center and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine have found that some tumor cells get separated from the parent tumors and then stimulate the connective tissue cells to release certain transmitters for promoting metastasis. This process is done to colonize the other organs and the detached tumors manipulate the environment according to their needs for creating the metastatic niche.

This discovery is helpful for scientists to better understand the mechanism that how these harmful metastases arise. This research paper is published in the journal Nature Communications.

When cancer spreads to other parts of the body from the initial site then the process is called metastasis. It usually develops when the cancerous cells break their connection from the main or parent tumor and move to the bloodstream or lymphatic system. Through these systems, the detached tumor travels far away from the main site and form new tumors when they settle down in specific tissue.

If the cancerous cells detached from the parent tumors, then many of them were died before colonizing other tissues and forming metastases. Because When a tumor detached from the parent tumor then the body immunes system gets activated and protects the healthy cells and tissues of the body from the intruding effects of cancerous cells.

These migrant cells will only survive in the body if they have the power to manipulate their new environment for creating the metastatic niche. This metastatic niche makes them survive in the body by protecting against the bodys immune system.

Thordur Oskarssan and his team of researchers from the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) are concerned in exploring the mechanism that how this metastatic niche evolves. Scientists found that in breast cancer some specific aggressive cells stimulate a certain condition which is similar to the inflammation in the lung tissue. So, it confirms that these cells colonize the other healthy tissues and promote metastases.

Also Read: Human Immune System is Effective Against a Number of Viruses

Two inflammatory signaling molecules known as interleukins are released from the detached cancerous cells. In microenvironment, these interleukins stimulate fibroblasts in the lungs to release two more inflammatory signaling molecules i.e. CXCL10 and CXCL9.

Migrant cancer cells carry receptors on their surface that attach to these signaling molecules which is a pivotal step during the process of metastases. The signaling molecules (CXL10 and CXCL9) and inflammation aid the particular aggressive breast cancerous cells to colonize other tissues and form metastases.

Maren Pein who is a lead author of the study said that the same tumors cells that provoke the fibroblast to release CXCL10 and CXCL9 also contain some other receptors for theses cytokines which help the growing process of metastases. This indicates that cellular communication between fibroblasts and detached cancerous cells in the new microenvironment is very crucial for metastasis.

During the experimental studies, scientists treated the lungs of mice with an inhibitor which blocked the receptors on the cancer cells. These inhibitors used to prevent the growing process of metastasis.

Scientists took tissue samples from the patients of breast cancer and found that the same cellular communication was also present in breast cancer cells. The process in which tumors cells having the relevant receptors utilize these interactions along with fibroblast to create the metastatic niche is also found in the breast cancer patients.

Oskarsson further explained that before developing any treatment approaches, it is necessary to understand the exact mechanism of metastasis. Initially, the study was carried out to explore the actual process that helps to arise metastases. A better understanding will enable scientists to develop different ways to prevent metastases in the future.

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How Crucial is the Cellular Communications Between the Detached Cancerous Cells and Fibroblast for Growing Metastasis - Spark Health MD

Sangamo Therapeutics: Market Cap Is At A Bargain Relative To Its Cash Position – Seeking Alpha

Introduction

Sangamo Therapeutics (SGMO) is a clinical-stage biotech company focusing on the research and development of genomic medicine across 4 distinct technology platforms: gene therapy, cell therapy, in vivo genome editing, and in vivo genome regulation.

Sangamo is best-known for developing its proprietary gene-editing technology, zinc finger proteins ("ZFPs"), which is a naturally occurring class of transcription factor proteins found in humans and other species. The company has used its internal know-how and technical expertise to develop a proprietary synthetic ZFP platform with potential clinical utility in ex vivo gene-edited cell therapy, in vivo genome editing, and in vivo genome regulation.

ZFPs also can be engineered to make zinc finger nucleases ("ZFNs") which proteins that can be used to specifically modify DNA sequences by knocking in or knocking out select genes, or genome editing, and ZFP transcription-factors ("ZFP-TFs") which are proteins that can be used to selectively increase or decrease gene expression.

Sangamo is developing a series of clinical programs, which are either wholly-owned or partnered with well-established pharma and biotech companies, to focus on 3 therapeutics areas in inherited metabolic disease ("IMDs"), central nervous system ("CNS), and inflammatory and autoimmune diseases. Its full list of clinical pipeline programs is listed in Figure 1.

Figure 1 Sangamo Therapeutics' Clinical Pipeline (Source)

The company's most advanced program is an investigational gene therapy for severe hemophilia A, SB-525. SB-525 is developed under a global collaboration with Pfizer (PFE), of which the rights of SB-525 have been transferred to Pfizer to run a phase 3 trial. In December 2019, both companies announced updated initial data from the phase1/2 trial of SB-525. SB-525 was generally well-tolerated and demonstrated a sustained increase in Factor VIII activity. SB-525 has been granted RMAT, Orphan Drug, and Fast Track designation by the FDA as well as Orphan Medicinal Product Designation by the European Medicines Agency ("EMA").

Beyond SB-525, the company is also investigating 2 wholly-owned gene therapy. ST-920 is being evaluated to treat Fabry disease, a rare inherited metabolic disease, in a phase 1 study in the US and UK. SB-920 has received Orphan Drug designation by the FDA. The company also plans to advance ST-101 into clinical trials in 2021 to treat phenylketonuria ("PKU") which is a rare inherited disorder that originates from a defect in the PAH gene and results in a harmful accumulation of phenylalanine in cells throughout the body.

Sangamo is working with Sanofi (NASDAQ:SNY) to develop ex vivo gene-edited cell therapies, ST-400 and BIVV-003, for transfusion-dependent beta-thalassemia ("TDT") and sickle cell disease ("SCD") respectively. Both ST-400 and BIVV-003 are related product candidates using the same technology involving gene editing of a patient's own hematopoietic stem progenitor cells using non-viral delivery of ZFN technology.

Sangamo is the phase 1/2 study of ST-400 in 6 patients with TDT while Sanofi is recruiting the phase1/2 study evaluating BIVV-003 in patients with SCD, and Sanofi is responsible for the subsequent development, manufacturing, and commercialization of both programs.

In Dec 2009, Sangamo presented interim results for the first 3 patients ST-400. As of the data cut date, 2 more patients have been enrolled although they were not included in the interim updates. The 3 patients treated with ST-400 experienced prompt hematopoietic reconstitution, demonstrating neutrophil engraftment in 14-22 days and platelet engraftment in 22-35 days. No emerging clonal hematopoiesis had been observed as measured by on-target indel pattern monitoring in the three treated patients. The downside of the data readout is that its treatment of TDT appears to be not as efficacious as other competitors such as bluebird bio (BLUE).

Sangamo also has a global collaboration and license agreement with Kite Pharma, a wholly-owned subsidiary of Gilead Sciences (GILD), for the development of engineered cell therapies for cancer. The company is working together with Kite to design ZFNs and viral vectors to disrupt and insert select genes in T cells and natural killer cells. The first program of this agreement expected to start a clinical trial in 2020 is KITE-307, which is an allogeneic anti-CD19 CAR-T cell therapy. Given the well-documented struggles of Kite's approved autologous CAR-T, Yescarta, the success of allogeneic CAR-Ts will be very beneficial.

Lastly, Sangamo is also evaluating the potential of regulatory T-cells ("Tregs") genetically modified with a CAR ("CAR-Tregs") in solid organ transplantation. CAR-Treg cell therapies are being conducted in several preclinical studies in autoimmune and inflammatory diseases such as multiple sclerosis ("MS") and inflammatory bowel disease ("IBD"). The most advanced CAR-Treg cell therapy is TX200, which is an autologous treatment for the prevention of solid organ transplant rejection and the clinical trial is expected to be initiated in 2020.

Sangamo is only planning to start a new clinical trial for its in vivo genome editing programs. SB-913 is a second-generation ZFNs program that will be used to treat Mucopolysaccharidosis type II ("MPS II") and a new clinical trial is planned to start this year.

The company had previous programs from first-generation ZFNs that have been halted as they did not demonstrate enough clinical benefits. The company plans to use data from the SB-913 study to definite the next steps for its in vivo genome editing programs.

The company also has several preclinical programs evaluating their ZFP-TF technology as a novel therapeutic approach for CNS diseases. In December, Sangamo announced a collaboration with Biogen (BIIB) to develop and commercialize ST-501 for tauopathies including Alzheimer's disease, ST-502 for synucleinopathies including Parkinson's disease, a third undisclosed neuromuscular disease target, and up to 9 additional neurological disease targets. Under the terms of the agreement, Biogen will pay Sangamo $350M upfront, inclusive of a license fee and equity investment, and Sangamo is eligible to receive up to $2.37B in future milestones.

Sangamo also has a partnership with Pfizer and Takeda (NYSE:TAK) to develop and evaluate ZFP-TFs. The company is working with Pfizer to evaluate ALS and frontotemporal lobar degeneration ("FTLD") that are linked to the mutations in the C9ORF72 gene. In the partnership with Takeda, the company is evaluating a preclinical program for Huntington's disease in which ZFP-TF is designed to differentially down-regulate the mutated disease-causing huntingtin gene ("HTT gene") while preserving the expression of the normal version of the gene.

As of 31 December, 2019, cash and equivalents on hand was $385M. The amount is excluding the $350M injection from the collaboration with Biogen, and when factored in, cash on hand should comfortably be in the range of high $600-700M. This should give them a comfortable runway to fund all operations well into 2021, an important point given that the recent stock market crash which limits any secondary offering options.

Impressively, the company has managed to strike several high-profile partnerships with 5 global biotech/big pharma companies. Such partnerships not only validate Sangamo's technology and capabilities, but they also provide future avenues of funding with as much as $6.34B royalties on net product sales and potential milestone payments due to the company.

Figure 1 Sangamo Therapeutics' Partnerships (Source)

In terms of competition, the company competes with several players, particularly in the cell and gene therapy space. bluebird bio has more advanced programs in both TDT and SCD and, to date, has shown much better efficacy. There are also other companies such as CRISPR Therapeutics (CRSP) that are using an alternative gene-editing method, CRISPR/Cas9 in gene therapy. Other companies such as Editas Medicine (EDIT) and Intellia Therapeutics (NTLA) are also developing CRISPR/Cas9 for treatments in TDT and SCD, although it must be noted that these are not their lead programs.

In terms of allogeneic CAR-T, there are more established players such as Allogene Therapeutics (ALLO), Cellectis (CLLS), and Precision Biosciences (DTIL). The main difference among these companies is primarily the choice of gene-editing tools with Allogene and Cellectis using TALEN while Precision is using ARCUS. All these companies are, currently, in a similar stage of clinical development.

In addition to healthy donors derived allogeneic therapies, Fate Therapeutics (FATE) is developing allogeneic therapies from induced pluripotent stem cells ("iPSCs") as a renewable cell source. The advantage of this is that product consistency and potency will be improved, and the manufacturing process will be akin to the well-established biologics where they are produced from a single cell line. It is notable to note that Allogene is also investigating using iPSCs as a renewable cell source. Also, Atara Biotherapeutics (ATRA) is developing an Epstein-Barr Virus ("EBV")-based allogeneic T cell therapy platform. Their lead program is in Phase 3 and a BLA filing is expected by the second half of the year. That should put them in the lead position of commercializing an allogeneic T cell therapy and the company is gradually moving into allogeneic CAR-T space as well.

Sangamo is, currently, trading at a market cap of around $700M, which is almost as much as its cash position. While its cash position will eventually deplete to fund operations and clinical trials, the current valuation means that there is also no value for its technology and intellectual position. I consider it a good time to take up a small position in Sangamo, especially if investors have a time horizon of at least a year to weather the COVID-19 black swan event and wait for further clinical updates from the company.

It must be cautioned though that investing in clinical-stage biotech can be extremely risky, given the binary nature of the field. This is especially so, given the market turmoil from the COVID-19 pandemic. The pandemic has also led to several countries announcing lockdowns, which have disrupted supply chain and operations. Several clinical trials have already been delayed globally and this may impact Sangamo negatively, as their cash burn will continue even if clinical trials are delayed.

Disclosure: I am/we are long ATRA, BLUE. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

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Sangamo Therapeutics: Market Cap Is At A Bargain Relative To Its Cash Position - Seeking Alpha

Partner Therapeutics Announces Initiation of Clinical Trial to Evaluate Leukine in Patients with COVID-19 Associated Respiratory Illness – P&T…

LEXINGTON, Mass., March 24, 2020 /PRNewswire/ --Partner Therapeutics, Inc. (PTx) announced that Leukine (sargramostim, rhu-GM-CSF)is being assessed in the SARPAC trial (sargramostim inpatients withacute hypoxic respiratory failure due toCOVID-19 EudraCT #2020-001254-22) at University Hospital Ghent to treat patients with respiratory illness associated with COVID-19. Major medical centers in Germany, Italy and Spain are considering joining the study. The study will evaluate the effect of Leukine on lung function and patient outcomes.

"Patients with COVID-19 who progress to acute hypoxic respiratory failure due to COVID-19 have very limited treatment options and a high mortality rate," said Prof. Bart Lambrecht, Principal Investigator for the trial at University Hospital Ghent and the Flanders Institute of Biotechnology (VIB). "We rapidly initiated this study with Leukine, because GM-CSF has profound effects on antiviral immunity, can provide the stimulus to restore immune homeostasis in the lung, and can promote lung repair mechanisms."

Granulocyte macrophage colony stimulating factor (GM-CSF) is essential for the health of the lungs. Alveolar macrophages, a cell type found in the lungs, are dependent on GM-CSF for differentiation and normal functioning. GM-CSF is an immunomodulator that plays a critical role in host defense against pathogens and maintaining proper functioning of the immune system.1 GM-CSF confers resistance to influenza by enhancing innate immune mechanisms.2 In animal studies, GM-CSF reduced morbidity and mortality due to acute respiratory distress syndrome (ARDS) from viral pneumonia.3 In clinical studies, use of Leukine showed beneficial effects in patients with viral pneumonia.4,5 Recent data highlight the importance of understanding the immune status of patients and role of immunomodulating agents like GM-CSF to activate the immune system to help clear virus and reduce the risk of secondary infections.6

"Partner Therapeutics is committed to investigating Leukine in patients with COVID-19 and we are working with academic and government agencies here in the US and in Europe in this effort," said Dr. Debasish Roychowdhury, Chief Medical Officer at Partner Therapeutics. "We believe, like many investigators and scientists, that GM-CSF has multiple ways by which it may help these patients, including playing a role in clearing the infection, boosting the immune system and repairing damaged tissues."

"In pre-clinical studies, GM-CSF protects the lungs from viral pneumonia and the influenza A virus", stated E. Scott Halstead, MD, PhD, Associate Professor, Penn State University College of Medicine, Department of Pediatrics, Division of Pediatric Critical Care Medicine. "Preliminary data indicate an apparent benefit of inhaled Leukine therapy for autoimmune pulmonary alveolar proteinosis ("aPAP") and suggest it has reduced the need for whole lung lavage therapy for patients receiving treatment. Collectively, the data suggest that aerosolized Leukine may prove to be a meaningful therapy to decrease mortality and increase ventilator-free days in patients with respiratory disorders associated with viruses such as COVID-19 and Influenza A."

For the treatment of COVID-19 associated acute hypoxic respiratory failure and ARDS, Leukine will be used in nebulized form for direct inhalation or through intravenous administration for patients already on a respirator. Nebulized Leukine has been studied in phase 2 and phase 3 randomizedtrials in pulmonary conditions that affect alveolar macrophages, such as aPAP. IV administration of Leukine has been studied extensively in other conditions and in phase 2 randomized trials in ARDS.

Leukine was initially approved in the United States in 1991 and has been approved for use in five clinical indications. Its safety and tolerability profile are well understood. In 2018, Leukine was approved for use as a medical countermeasure to treat Acute Radiation Syndrome (ARS) and has been procured for use by the U.S. Strategic National Stockpile. Leukine is distributed outside the U.S. on a named-patient basis through PTx's designated program manager, Tanner Pharma Group. The use of Leukine to treat respiratory disorders associated with COVID-19 is investigational and has not been fully evaluated by any regulatory authority.

Please see full Prescribing Information for LEUKINE at http://www.leukine.com

About Leukine(sargramostim)Leukine is a yeast-derived recombinant humanized granulocyte-macrophage colony stimulating factor (rhuGM-CSF) and the only FDA approved GM-CSF. GM-CSF is an important leukocyte growth factor known to play a key role in hematopoiesis, epithelial repair, and augmentation of innate host defense by effecting the growth and maturation of multiple cell lineages as well as the functional activities of these cells in antigen presentation and cell mediated immunity.

Important Safety Information for LEUKINE (sargramostim)

Contraindications

Warnings and Precautions

Adverse Reactions

Adverse events occurring in >10% of patients receiving LEUKINE in controlled clinical trials and reported in a higher frequency than placebo are:

Please see full Prescribing Information for LEUKINE at http://www.leukine.com

Indications and Usage

LEUKINE (sargramostim) is a leukocyte growth factor indicated for the following uses:

About Partner Therapeutics, Inc.: PTx is an U.S.-based commercial-stage biotech company focused on the development and commercialization of therapeutics that improve health outcomes in the treatment of cancer. PTx's development focus spans the entire range of cancer therapy from primary treatments to supportive care. The company believes in delivering great products with the purpose of creating the best possible outcomes for patients and their families.

References

Cited References

Other RelevantReferences

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Unlocking the Potential of a Widely Used Drug – Technology Networks

The blood-thinning drug heparin is used all over the world. But, the underlying sugar structures of heparin and the wider family of heparan sulfate sugars in cells have not been fully mapped. Now, a research group headed by a recent recruit from the UK, Dr Rebecca Miller at the University of Copenhagen has invented a method to map this type of sugar structure in detail. This method has vast potential to reveal important biological functions and allow new drugs to be developed.

GAGs of the heparan sulfate type play key roles in regulating many biological functions, including inflammation, neurodegeneration and tumor metastasis. In fact, a special type of heparan sulfate called heparin is currently one the most used drugs in the clinic where it is used to prevent coagulation. Researchers are therefore intensively trying to map the detailed structures of heparan sulfates and link them to their biological functions.

So far, only a few structures have been successfully identified, but that may be about to change. In a new study inNature Communicationsfrom the Danish National Research Foundation Centre for Glycomics at the Department of Cellular and Molecular Medicine, University of Copenhagen, Rebecca and her team has invented a new method that will boost the mapping of these structures.

Determining the structures is a key question in the research about sugars. If we know the structure, we can determine what the cues are for specific biological functions and consider potential ways to exploit this in the development of therapeutics. This is hugely important and clinically relevant, as shown by the widely used anti-coagulant heparins, and the potential application of new heparin-based drugs for multiple diseases in the future, says Dr Rebecca Louise Miller, corresponding author of the new study and Assistant Professor at the Copenhagen Center for Glycomics.

The researchers new method is called Shotgun ion mobility mass spectrometry sequencing or SIMMS2. The technique relies on advanced mass spectrometry to break the sugar structures into smaller fragments, separate them, and fingerprint them compared to known standards. Virtual reassembly of the sugar pieces into a picture of the original sugar like a big jigsaw puzzle only infinitely more complicated can for the first time determine larger sequences of polysaccharides that are big enough to capture the cues that direct functions like anti-coagulation.

The instrumentation behind this new method was invented by the company Waters Ltd in 2006 and is available to many pharmaceutical companies and researchers. This means that the method could be easily implemented and widely used for drug discovery by many research groups in a short period of time, says Professor Jeremy Turnbull, University of Liverpool and Copenhagen Center for Glycomics, a co-author on the study.

The GAG team at Copenhagen Center of Glycomics recently reported the first cell-based method (GAGOme) to produce all variants of GAGs for discovery of functions and development of therapeutics (Chen et al,Nature Methods2018), and this will be combined with the new method for sequencing of GAG structures. The hope is to follow up on many promising therapeutic effects of heparins in cancer and neurogenerative diseases and pioneer new use of GAGs in medicine.

To continue the development of the SIMMS method and pioneer new use of GAGs in medicine, Miller and Turnbull were recently awarded an EU grant worth 3.8m to a consortium that also includes researchers from Freie Universitt Berlin, University of Utrecht, University of Liverpool and Karolinska Institutet in Stockholm. They will also apply the method to understand heparan sulfate structural cues that regulate stem cells to generate specialized neurons for treatment of Parkinsons disease.

Reference:Miller, R.L., Guimond, S.E., Schwrer, R. et al. (2020) Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides. Nat Commun. DOI: https://doi.org/10.1038/s41467-020-15284-y

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Unlocking the Potential of a Widely Used Drug - Technology Networks