Stem Cell Therapy for COPD: What You Need to Know | COPD.net

When you have a chronic, incurable disease, its natural to be interested in research and new therapies that might offer hope and a solution that current treatments do not. Stem cell therapy is one of the most talked about and advertised potential new COPD treatments today. Its hard to do any search for COPD on the Internet without running into an ad or claim about stem cell therapy for COPD. In fact, one of the most highly regarded COPD blogs push stem cell treatment in almost every article they publish.

But is this a valid treatment? Or it some kind of scam?

Stem cells are a type of cell in the body that can regenerate on their own. During normal cell division,each new cell can choose either to remain a stem cell or become a different type of cell with a more specialized function. For example, stem cells might become muscle cells, red blood cells or brain cells. In some cases, they have proven useful as a sort of internal repair system.1

So, in other words, stem cells differ from other types of cells in two ways: 1

In the gut and bone marrow, stem cells regularly divide and repair or replenish the body tissues on their own. On the other hand, in other types of body organs, such as the heart and pancreas, stem cells will only behave like that when special conditions exist.

Stem cells can be obtained from both embryos (notably, mouse embryos) and adult tissues. Stem cells in embryos are what eventually morph into the entire organism. In adults,stem cells become replacements for cells that have been lost through normal wear and tear, injury, or disease. 1

Because of their regenerative abilities, stem cells do seem to offer some hope for treating certain illnesses. However, there is still much research to be done to prove the safety and effectiveness of stem cell therapy. Most research to date has been done in laboratories with mice, not with humans in the real world.

Also, while embryonic stem cells are able to replicate and form different types of specialized cells, the same may not be true for adult stem cells. Instead adult cells tend to generate the same types of cells as in the organ where they reside.1 Some scientists believe stem cells can be reprogrammed, given the right conditions. Whether or not this is true is a big debate in the scientific community.

While stem cells have been identified in many other parts of the body, experts did not believe they existed in lung tissue until the last decade or so. With this discovery, there was a surge of interest in using stem cell therapy for COPD.2

Certain cells in the smallest parts of your airways, the alveoli, can be destroyed by tobacco smoking or regular exposure to other harmful substances. This leads to difficulties in gas exchange (oxygen and carbon dioxide), resulting in the typical symptoms of COPD.3 Research done in the lab on animal models has shown promise in:3

However, to date, human clinical trials have failed to show any real benefit when stem cell therapy is used to treat COPD.3 Some experts theorize that result might be better when stem cell therapy is used earlier on in the development of COPD. However, the alternate take on this is that more traditional forms of therapy are also more effective when begun early. So there may be no real advantage to stem cell treatment. Or, could there be? We just dont know yet.

TheInternational Society for Stem Cell Research published an extensive article on things to be aware of when it comes to stem cell therapy.4 I highly encourage you to read it before pursuing stem cell therapy for COPD. They caution:

Many clinics offering stem cell treatments make claims that are not supported by a current understanding of science.

Here is a synopsis of their advice:

Also, most stem cell therapy clinics are extremely expensive and are not covered by insurance. And they do not offer a guarantee that theyll even work, especially for COPD.

Stem cell research is extremely promising. There have already been successes in treating blood-related diseases with stem cells derived from the blood.5 On the other hand, the results have been quite mixed when using stem cell therapy for other diseases, especially COPD. But research is progressing and more clinical trials are being developed each year. So perhaps one day soon, we will see a viable stem cell therapy for COPD. But that day has not yet arrived, no matter what youve heard.

This article represents the opinions, thoughts, and experiences of the author; none of this content has been paid for by any advertiser. The COPD.net team does not recommend or endorse any products or treatments discussed herein. Learn more about how we maintain editorial integrity here.

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Stem Cell Therapy for COPD: What You Need to Know | COPD.net

Stem Cell Therapy for Erectile Dysfunction | Stem Cell …

*Note: For the investigational use of Adipose-Derived Stem Cells (ADSCs) for clinical research and deployment.

Erectile Dysfunction (ED) can have an emotional impact on men, affecting both self-confidence and personal relationships. For many years, treatment for ED was palliative in nature and relied on the use of medication in a timely manner. Although popular medications can be successful in enabling an erection in approximately 75% of patients, the inability to be truly spontaneous in intimacy and possible side effects often diminished their true effectiveness. In addition, medications can begin to lose effectiveness or stop working completely when used continuously.

Recent scientific studies have shed light on both the underlying causes of ED and new treatment options that address them, instead of treating only the symptoms. There are exciting new treatment options for men suffering from erectile dysfunction that can provide natural and lasting results without medication, including stem cell therapy. A pioneer in the use of stem cells for regenerative medicine, Dr. Todd Malan offers treatment for ED that uses the bodys own resources to repair damaged tissue and restore your ability to experience sexual satisfaction with a spontaneous erection.

Using stem cells, Dr. Todd Malan is able to help men achieve stronger and longer-lasting erections without the use of medications or external support devices. Stem cells actually repair damaged blood vessels for improved blood flow, making this a truly regenerative treatment.

In the past, erectile dysfunction was believed to be a psychological condition. We now know that there are a number of factors that can contribute to ED. It is a very common condition, affecting as many as 30 million men in the United States. Impotence can affect any man at any age, however, it is more common in older men. The incidence of erectile dysfunction also increases with age. Major risk factors include:

One of the most common reasons for erectile dysfunction is damaged blood vessels and reduced blood flow to the penis, which can be caused by any of the factors above. The ability to achieve and maintain an erection is dependent on the capability of the veins in the penis to respond to certain stimulation. Blood vessels must also be able to maintain dilation for the maintenance of an erection. With age, those veins begin to have micro-damage, which is normal with all blood vessels in every area of the body.

Dr. Malan is able to repair that damage with stem cell therapy so that the blood vessels are able to better respond to a stimulus due to sufficient blood flow and produce a stable, more prominent erection.

The Era of Regenerative Medicine: New Hope for Treating EDIt is estimated that as many as 30 million men in the United States are affected by erectile dysfunction. Past treatments focused on the management of symptoms. Stem cells are being widely used by medical doctors to regenerate damaged tissues and blood vessels. In sports medicine, stems cells are highly effective in repairing musculoskeletal injuries.

Applying this knowledge to the treatment of erectile dysfunction, Dr. Malan and other leading physicians are using stem cells to regenerate damaged blood vessels in the penis. These therapies help men achieve longer-lasting, much larger erections than they would normally be able to achieve. Because stem cells have the ability to replicate themselves, they can actually heal the damaged vessels.

There are many different types of stem cells. For the treatment of erectile dysfunction, three types of adult stem cells are commonly used:

Dr. Malan is a pioneer in the use of ADSC. He has developed a technique that involves the use of advanced liposuction to harvest fat cells and a sophisticated purification process to produce a stem cell-rich gel that is then injected into the blood vessels in the penis.

Why Fat Stem Cells?Harvesting adipose-derived stem cells (ADSCs) is much easier and less invasive than harvesting either bone marrow or muscle-derived stem cells. Fat is abundant in the body and is obtained using minimally invasive liposuction. ADSCs have a significantly higher concentration of mesenchymal stem cells, which have the ability to self-renew, clone, and differentiate into multiple tissues.

This procedure is also referred to as autologous stem cell therapy, which means the donor and the recipient are the same people. Because of the high volume of stem cells found in fat tissue, there is no need to culture the cells or wait for them to grow. They can be harvested, concentrated into a stem cell-rich mixture and re-injected into the treatment area on the same day of the procedure.

Throughout the United States, it is popular among doctors to use liquid-based stem cells. Dr. Malan uses the latest technique, developed in Europe, to use a gel or paste stem cell mixtures, which produce far better results.

You dont need to leave the United States to get expert treatment.The Innovative Cosmetic Surgery Center is a leader in stem cell therapies. Dr. Malan trains physicians from around the world in this and other procedures. Our treatments are performed according to FDA standards in our Scottsdale clinic. Your safety and comfort are our foremost concern.

Arizona is the ideal location for a medical vacation. We offer free virtual consultations to discuss your concerns and treatment options. Dr. Malan hosts men from all over the United States for the treatment of erectile dysfunction. Explore your options. Call us at (480) 998-7999 or request an appointment online.

If youve been suffering from erectile dysfunction, now is the time to do something about it. Stem cell therapy is highly effective, minimally invasive and completely safe for the treatment of ED. We routinely host men from all over the United States and will help coordinate the details of your travel if you are out of state.

Call us today for a consultation (480) 998-7999 or request an appointment online.

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Stem Cell Therapy for Erectile Dysfunction | Stem Cell ...

Stem Cell Therapy for Knee Pain – Vitality Medical Centers

For many patients with debilitating knee pain, treatment options are limited: steroid injections, high doses of pain medications, bracing and ultimately joint replacement surgery. In the last few years, innovative treatment options like stem cell injections are now being used to successfully treat patients with a multitude of degenerative orthopedic conditions.

How does stem cell therapy work and what benefits does stem cell therapy offer?

Stem cell therapy is a regenerative injection technique that infuses a damaged joint with stem cells, as well as the other components: growth factors that stimulate tissue growth, hyaluronic acid (a natural joint lubricant/buffer that improves mobility), and naturally occurring anti-inflammatory agents such as cytokines et. al. While this matrix has anti-inflammatory properties, much like cortisone and steroid shots, the beneficial effects of stem cell therapy goes well beyond the benefits and capabilities of standard injection therapy. Stem cell injections also have antimicrobial (germ-killing) and anti-fibrotic (i.e. ability to break down scar tissue) properties as well.

Injectable steroids and oral or topical pain medications only provide temporary pain relief and to nothing to address the underlying problem; stem cells restore damaged tissue while providing pain relief. The growth factors in stem cells may replace damaged cells in your body.

Are stem cell injections safe?

While there are risks with any procedure that involves injections, the laboratory that Vitality Medical Centers uses for their stem cells has a long history of stem cell injection procedures without a single reported adverse effect. There are, of course, always risks associated with any injection procedure (e.g. pain, bleeding, risk of infection, etc.) but sterile technique and administration by a trained physician minimizes these risks.

Am I a candidate for stem cell therapy?

Patients suffering from any kind of joint, tendon, or ligament pain may be potential candidates for stem cell therapy. Please keep in mind that not every patient is a reasonable candidate for stem cell therapy and that results from these injections may vary from no response to complete relief of symptoms. Upon evaluation, our physician may be able to provide you with alternative recommendations for treatment of particular conditions, such as physical therapy, viscosupplementation, prolotherapy or PRP (platelet rich plasma) injections, chiropractic care, etc.

What if I have a torn knee ligament?

Stem cell therapy can treat torn knee ligaments as long as there is not a complete tear. In cases where the tear is severe, but there are still some fibers attached, a higher number of injections may be required. Typically, the less severe the injury, the fast the healing time. Factors such as age, obesity, tobacco use, and other health factors can influence the number of injections needed as well as the healing time.

How long will it take me to recover?

The procedure itself takes about an hour in the office. After the procedure, tissue typically takes between one and three months to repair itself, but most patients will notice a change in their symptoms within one to two months. While the total number of injections required may vary depending on age and the type and severity of the condition, most patients require 2-4 sets of injections spaced apart.

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Stem Cell Therapy for Knee Pain - Vitality Medical Centers

Stem Cell Hair Transplant: What Is It and When Will It Be …

A stem cell hair transplant is similar to a traditional hair transplant. But rather than removing a large number of hairs to transplant to the area of hair loss, a stem cell hair transplant removes a small skin sample from which hair follicles are harvested.

The follicles are then replicated in a lab and implanted back into the scalp in the areas of hair loss. This allows hair to grow where the follicles were taken from, as well as where theyre transplanted.

Stem cell hair transplants exist only in theory at the moment. Research is ongoing. Its estimated that stem cell hair transplants may be available by 2020.

Stem cells are cells that have the potential to develop into different types of cells found in the body. Theyre unspecialized cells that are unable to do specific things in the body.

However, theyre able to divide and renew themselves to either stay stem cells or become other types of cells. They help repair certain tissues in the body by dividing and replacing damaged tissues.

A stem cell hair transplant was successfully performed by Italian researchers in 2017.

The procedure begins with a punch biopsy to extract stem cells from the person. The punch biopsy is performed using an instrument with a circular blade thats rotated into the skin to remove a cylindrical sample of tissue.

The stem cells are then separated from the tissue in a special machine called a centrifuge. It leaves a cell suspension thats then injected back into the scalp in the areas of hair loss.

There are several different research teams working on stem cell hair loss treatments. While the procedures may vary slightly, theyre all based on growing new hair follicles in a lab using a small skin sample from the patient.

Currently, there are some clinics offering a version of stem cell hair transplants to the public. These arent approved by the U.S. Food and Drug Administration (FDA). Theyre considered investigational.

In 2017, the FDA released a warning about stem cell therapies. The warning advises anyone considering stem cell therapies to choose those that are either approved by the FDA or being studied under an Investigational New Drug Application (IND). The FDA authorizes INDs.

These procedures are performed in-office on an outpatient basis. They entail removing fat cells from the persons abdomen or hip using a liposuction procedure under local anesthesia.

A special process is used to remove the stem cells from the fat so that they can be injected into the scalp. This procedure takes approximately 3 hours.

The clinics that currently offer this procedure cant provide a guarantee for the outcome of the procedure. The results, if any, can vary from person to person. It may require several treatments over many months to see results.

Some research has found stem cell hair transplants can be effective in treating different hair loss conditions, including:

Some pain following the procedure is expected. It should subside within a week.

No recovery time is required, though excessive exercise should be avoided for a week. Some scarring can be expected where the fat has been removed.

You wont be able to drive yourself home following the procedure because of the effects of the local anesthesia.

Theres very little information available about the possible side effects of stem cell hair transplants. As with any medical procedure, theres always the risk of bleeding or infection at the site of the sample and the injection. Scarring is also possible.

Though complications from a punch biopsy are rare, theres a small risk of damage to the nerves or arteries beneath the site. Liposuction can also cause the same side effects and complications.

The research available on the success rate of stem cell hair transplants is very promising. The results of the Italian study showed a 29 percent increase in hair density 23 weeks after the last treatment.

The clinics that currently offer stem cell hair therapies not approved by the FDA dont make any guarantees in regard to results or success rates.

The cost of stem cell hair transplants hasnt been determined since theyre still in the research stages.

Some of the investigational stem cell hair replacement therapies being offered by various clinics range from approximately $3,000 to $10,000. Final cost depends on the type and extent of the hair loss being treated.

The stem cell hair transplant treatments being researched are expected to be available to the public by 2020. Stem cell hair transplants offer options to people who arent candidates for the hair loss treatments currently available.

While some clinics are offering stem cell hair replacement therapies, these are considered investigational and havent been approved by the FDA.

Continued here:
Stem Cell Hair Transplant: What Is It and When Will It Be ...

SELLAS Positive Trial Data, And Other News: The Good, Bad And Ugly Of Biopharma – Seeking Alpha

SELLAS Life Sciences Announces Positive Readout for Leukemia Drug

SELLAS Life Sciences' (SLS) stock shot up as the company reported positive results from its Phase 1/2 study of its Galinpepimut-S treatment for patients with acute myeloid leukemia. The trial demonstrated that the patients treated with the drug candidate showed significant improvement in the survival rate. The median overall survival stood at 21 months while median follow-up remained at 30.8 month, in comparison to 5.4 months in patients treated with best standard care.

SELLAS had earlier reported initial data from the Phase 1/2 study of GPS. The median follow up in that read out was at 19.3 months, while median Overall Survival was 16.3 months, in comparison to 5.4 months in patients given best standard therapy. Angelos Stergiou, MD, ScD h.c., President and Chief Executive Officer of SELLAS, said, Were extremely pleased with this follow-up data, which show that GPS may have potential as a longer-term therapy for AML patients in CR2, an aggressive disease where the majority of patients typically relapse and have a survival rate of approximately 5 months with best standard therapy.

SELLAS is currently working towards recruiting patients for the ongoing Phase 3 REGAL study. It is a 1:1 randomized, open label study which compares GPS monotherapy in the maintenance setting to investigators choice of best available treatment. The trial is aimed at AML patients with hematologic complete remission, with or without thrombocytopenia (CR2/CR2p), after second-line antileukemic therapy. These patients have been found ineligible for or unable to undergo allogeneic stem-cell transplantation. The primary endpoint of the study is related to Overall Survival from the time of study entry whereas the secondary endpoints are related to antigen-specific T-cell immune response dynamics, leukemia-free survival and measurable residual disease by multigene array among others.

In January, the company provided highlights of its clinical development progress and upcoming catalysts during 2020. SELLAS expects to release interim analysis of the Phase 1/2 basket study of GPS with pembrolizumab in multiple tumor types during the second half of 2020. It also anticipates receiving guidance from the FDA on the regulatory and development pathway for NPS in TNBC patients in the first quarter of 2020.

For its third quarter, the company had reported its research and development expenses at $1.8 million, up from $1.7 million it had spent during the third quarter of the previous year. Its general and administrative expenses for the quarter were reported at $2.4 million while the corresponding figure for the previous year quarter was at $1.3 million. SELLAS reported its cash and cash equivalent at $9.1 million as of September 30, 2019. The company announced that its net loss attributable to common stockholders was $11.5 million while its net loss for the third quarter of the previous year was at $9.4 million. The net loss for the nine months stood at $20.5 million, down from $27.9 million in net loss for the corresponding time period of the past year.

SELLAS had a turbulent past year when its stock tumbled more than 97 percent in the stock market. The latest positive news is expected to bring some respite; however, investors are still advised to remain cautious. One of the biggest concerns about the company is its lack of income stream. The company has yet to report any revenue. SELLAS has robust drug pipeline with several ongoing trials. It is testing GPS in combination with Keytruda as a basket study for 5 indications. It is also working on testing drug candidate for treating Malignant Pleural Mesothelioma and Multiple Myeloma. SELLAS has NPS clinical trials going on for breast cancer as well.

Endo International (ENDP) reported its fourth-quarter results where it surpassed revenue and net income estimates. The company announced its EPS at $0.74, beating consensus estimate of $0.57. Its revenue for the quarter stood at $764.8 million, surpassing the market estimate of $731.43 million. However, its revenue dropped 3 percent on a year-over-year basis as it had earned $786 million in revenue during the fourth quarter of the previous year.

Endo also provided segment wise update where its revenue from the Sterile Injectables segment increased by 10% to $285 million. The increase was mainly due to the continued robust growth of Vasostrict and Adrenalin. The companys Generic Pharmaceuticals revenues dipped 14% due to the competitive pressure on generic products.

Endo provided guidance for FY 2020 as it expects its total revenue to be in the range of $2.72 billion and 2.92 billion. Its adjusted EPS from continuing operations will likely be between $2.15 and $2.40. The consensus estimates for EPS stands at $2.25 while revenue is expected to be $2.90 billion. Paul Campanelli, Chairman, President and Chief Executive Officer at Endo, said, In 2019, Endo delivered stronger than expected performance during the fourth quarter and for the full year, driven by continued double-digit percentage revenue growth in our Sterile Injectables segment and in the Specialty Products Portfolio of our Branded Pharmaceuticals segment, and as a result of our dedication to operational execution.

Endo is engaged in the development and marketing of branded and generic pharmaceuticals in the United States. The company has strong pipeline and has multiple trials going on for treating different ailments. Some of its most prominent products are Testopel, Fortesta and Xiaflex.

Menlo Therapeutics (MNLO) announced that its Phase 2 clinical for treating chronic pruritus of unknown origin failed to meet its primary endpoint. The trial involved patients treated with one a day daily oral serlopitant. The data demonstrated that there was no meaningful difference between the placebo group and serlopitant group. The main purpose of the study was to demonstrate reduction in itching as measured by a rating scale.

The study showed that 37.9 percent of patients treated with serlopitant achieved a 4 point or greater improvement on the rating scale. However, the placebo group showed 39.3 percent of patients hitting that mark. The placebo group also showed 10 percent higher response than in any of the previous studies testing the once-daily pill. The company CEO Steve Basta said that there is no such indication that such a high rate would be replicated in future studies. He added, That would be putting undue weight on the [chronic pruritus of unknown origin] results. I think what youll see is this is an outlier. He also said that, The higher placebo response rate may be due to characteristics of the CPUO population, which is not well understood clinically.

The company expects the results from Phase 3 trials for the treatment of pruritus associated with prurigo nodularis to be out in the months of March or April this year.

However, this is not the first time the placebo effect has disrupted serlopitant tests. The company suffered two mid-stage failures, involving the testing of drugs for managing itching in atopic dermatitis and chronic cough. These research and development measures will now likely take place under the management of Foamix. Menlo and Foamix have agreed for an all-stock merger, which was approved by Menlo shareholders in January. It is expected that the agreement will close on or around March 9, 2020.

Thanks for reading. At the Total Pharma Tracker, we do more than follow biotech news. Using our IOMachine, our team of analysts work to be ahead of the curve.

That means that when the catalyst comes that will make or break a stock, weve positioned ourselves for success. And we share that positioning and all the analysis behind it with our members.

Disclosure: I/we have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

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SELLAS Positive Trial Data, And Other News: The Good, Bad And Ugly Of Biopharma - Seeking Alpha

‘Survivor 40’: Why Ethan Zohn Doesn’t Think it Was a Smart Idea to Return for ‘Winners at War’ – Showbiz Cheat Sheet

Who doesnt love a good redemption story? Survivor: Winners at War was designed to bring former Survivor winners together and give them another chance at glory, but there is one winner in particular who this season is especially sweet for. Ethan Zohn won the competition in 2001 and then competed on the All-Stars season in 2004. Now, hes back for Winners at War after a 15-year hiatus. During that break from tv, Zohns real life became a game of Survivor, so he originally didnt think that returning to the actual show was the greatest idea.

In 2009, Zohn was diagnosed with CD20-positive Hodgkins lymphoma. After a year of treatment, he went into remission. But his battle wasnt over. Over a year and a half later, the cancer came back in his chest. In 2013, he beat the cancer again and went into remission.

After getting healthy, he was invited to come back to Survivor in 2016 but turned it down.

After beating cancer twice, Zohn felt it was time to come back and play the game again.

The fact that I was part of this show way back in the day and had the opportunity to play again, for me, it was a huge gift, he told Entertainment Tonight. Ive been through some health challenges and Iremember sitting in the hospital room watchingHeroes vs. Villains, getting my second stem cell transplant and dreaming to myself that someday Id be healthy enough mentally, physically, spiritually to be able to go playSurvivoragain. When they called for season 40, I instantly said yes because it was just getting to this point in my life, to be able to go playSurvivorfor me was, like, thats winning for me.

But going into the game this time was different than Zohns previous two stints on the show as his mindset had changed.

Having gone through such a major health challenge and recovering from that [was hard], he said. Going through cancer isdifficult but for me, personally, it was the after-effects that was the most difficult. Im a giant ball of anxiety. I live in fear that my cancer is going to come back for a third time, and it just does something to you.

Zohn was able to use the fact that people underestimated him to his advantage. No one knew that much about him as he hadnt played the game in over a decade. He was, however, voted out in the third episode.

Despite enjoying playing in Winners at War, Zohn doesnt think hell compete again.

I dont think I dont know! he said when asked if he would do Survivor again. Its so I just want to put into perspective where, and Im not trying to be the poor me, crying B, but building yourself back up after cancer isa difficult process. AndSurvivor, the game itself, there are moments like I said, I was afraid to go out there without my toolkit that I had and I just didnt know what it would do to me but it screws you up mentally and physically and spiritually and socially. It messes you up.

I just dont know at this age, and what Ive been through health-wise, that I could ever really I dont think it would be a smart decision to go, he continued. I dont think it was a smart decision to play this time, but I think it would be an even worse decision to go next time, health-wise.

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'Survivor 40': Why Ethan Zohn Doesn't Think it Was a Smart Idea to Return for 'Winners at War' - Showbiz Cheat Sheet

Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market to Surge at a Robust Pace in Terms of Revenue Over 2020 to 2025 – News Times

The Global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market report by Globalmarketers.Biz sets out the production, consumption, revenue, gross margin, cost, gross, market share, CAGR, and global market influencing factors of the market for 2020-2025. The segmentation of regional market included the historical and forecast mandates for North America, Europe, Asia-Pacific, Latin America, the Middle East and Africa. The Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market report provides a far-reaching industry analysis by types, applications, players and regions.

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Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market to Surge at a Robust Pace in Terms of Revenue Over 2020 to 2025 - News Times

Colne woman widowed after husband dies just six months after wedding – LancsLive

A woman from Colne was left widowed after losing her husband to cancer just six months after their wedding.

Emma Smith has told how her husband Scott died after a battle with Hodgkins Lymphoma - a type of blood cancer - in August last year.

The pair - who met in their teens - had got married just six months earlier in March.

The 29-year-old said: "Scott and I met when I was 18 and he was 19, we were both on a night out in Burnley. I remember saying to Scott that I didnt want a boyfriend as I was going away to university in Birmingham and I wasnt going to be coming home every weekend!

"But he said that was fine, and the rest is history."

Just over two years ago, Scott Smith, a 29-year-old firefighter, discovered a lump on his neck.

Due to his dad having recently died from prostate cancer, he was particularly aware of his health and went straight to see his GP.

Emma added: "His GP said it wasnt anything serious. Scott wasnt happy so he went back again and saw the practice manager who told him to come back in six weeks if the lump hadnt gone."

After returning to his GP six weeks later, Scott was referred to hospital for tests which revealed that he had Hodgkins Lymphoma - a type of blood cancer.

Emma said: "We were told that if you get cancer, this is the one you want to get as its so curable and easy to treat. Six months of chemotherapy and then you should be fine.

"Because of this we really thought everything was going to be okay, but things didnt work out that way at all."

A few days after receiving his diagnosis, Scott started chemotherapy and radiotherapy. However, he didnt respond to treatment like doctors had hoped.

This is when the possibility of a stem cell transplant was first mentioned. Despite numerous knock backs, Scott approached the road ahead with positivity and bravery.

The Colne woman explained: "We were told if chemo works, he will need a transplant. That was the dream, a transplant. The chance of a cure."

Emma and Scott had got engaged in 2017 and had their wedding booked for April of last year.

Due to Scotts diagnosis, they took the decision to cancel the wedding in advance, as they thought Scott would be too ill to go ahead with the day.

Emma recalled: "However when we were sat in the hospital one day, we decided to get married. We were madly in love and best friends, we wanted to spend the rest of our lives together.

"Just six weeks later we got married surrounded by our closest friends and family, it was a magical day filled with love and laughter."

Shortly after their wedding, Scott developed a hole between his oesophagus and bronchial, which was caused by the cancer and worsened by the radiotherapy he was having. This resulted in fluid directly entering his lungs and he developed pneumonia after pneumonia.

Emma explained: "At this point we were told that we had two options, stop the radiotherapy and give Scott end of life care or they could attempt to reconstruct Scotts airways, but we were told that he could be in hospital for up to two years and chances are he wont survive.

"So, they gave us two choices but really there was only one."

In April, Scott stopped all treatment and Emma stopped work to care for him.

Emma's sisters, Hannah and Charlie, and the rest of their close family and friends rallied around both her and Scott during this time.

Scott died in August, at the age of 30.

Emma said: "The week before Scott died our friends and family didnt leave the house. Charlie lived in London but came to stay with her boyfriend, Lynas and Hannah was even with Scott when he passed away.

"Im so close to my sisters, we speak numerous [times] a day. Its the little things, Hannah has given me a house key and they took me away between Christmas and New Year, as they knew it was going to be a difficult time.

"The list of things they do for me is endless, Im very lucky. As clich as it sounds, I couldnt have got through it without them.

"I know that Scott took great comfort in knowing I had them by my side."

Before Scott died, Emma talked to him about doing the London Marathon and after asking Hannah and Charlie if they would be up for the challenge, the three of them signed up for the 2020 event together.

They are raising money for the blood cancer charity Anthony Nolan.

The trio call themselves the Hope Runners as they aim to give hope to other people like Scott, who sadly died before he was able to have a stem cell transplant.

Emma claims running has helped her to cope since the passing of her husband.

She said: "Weve set ourselves a big goal for fundraising and training to give us something amazing and positive to focus on in what we know will be the hardest year.

"Weve seen each other through the darkest of times so if we can get through that together, we can get through a marathon."

Anthony Nolan is the charity that finds matching donors for people with blood cancer and gives them a second chance of life.

The charity also carries out ground-breaking research to save more lives and provide information and support to patients after a stem cell transplant.

Anna Scalera, head of events and community at Anthony Nolan, said: We are delighted that the Hope Runners are lacing up her trainers and running theLondon Marathonfor us this year.

"With every mile completed they will be providing hope. The funds they raise will enable us to recruit more potential stem cell donors to the Anthony Nolan register any one of whom could give a second chance of life for someone with blood cancer.

To find out more about The Hope Runners, or to make a donation, click here.

Originally posted here:
Colne woman widowed after husband dies just six months after wedding - LancsLive

Brief respite for Wills in cancer battle – Pentiction Western News

Its Saturday afternoon and nine-year-old Wills Hodgkinson has just returned from visiting a friend. Upstairs in the playroom of his familys Naramata home, his attention is divided between the shiny new Yamaha drum set and the Mighty Ducks movie playing on television.

This is the best part, he said, cranking up the volume on the remote for the critical scene of the show. Its just a really well-made movie, I like the storyline. This is the second Ducks movie, the first one was really good but the third one sucks.

For most kids his age, this would not be anything special. But for Wills, who for the second time in his young life is battling cancer, its anything but typical.

Last week Wills, his father Tim and younger sister Scarlett got to come home from B.C. Childrens Hospital for the first time as a family since late December when Wills had surgery and began chemotherapy again.

But at least for a few days, even with the medical tubes still attached to the outside of his chest, the punishing hospital routine is a lifetime away.

Im feeling really good, its nice to come home and see my friends. I just got back from my best friend Jordans an hour ago and hes coming over tomorrow morning, weve been friends for five years, ever since kindergarten, said Wills with his ever-present smile. Its really great to see my friends, theyve been there to see me at the hospital and its really important that I get to see them again, I miss them.

READ MORE: Nine-year-old Penticton boy fighting cancer with a smile

The other fun thing he got to do on this trip home: I went to school again on two days and saw my other friends and everybody was glad to see me again and they asked about the hospital and I told them some stuff. It was fun.

Wills is in Grade 4 at Holy Cross School and staff and students have been in close touch, even buying him an iPad so they could Facetime back and forth and allowing him to participate in class when hes able.

In Feb. 2018, Wills was diagnosed with a Wilms tumour, a rare kidney cancer that primarily affects children. Then, just before Christmas almost a year past he was cleared two new tumours on his lung were discovered and treatment began all over again, including surgery to remove one of them.

Coming home for Wills has been immense, massive, said his father, Tim. Its so important to have that human contact, for him to sleep in his bed, have his toys, with all the best intentions in the world you cant replace that, theres nothing like it.

Just to let him be part of normal life, he gets to swap being a cancer patient for being a kid again.

Hodgkinson admitted it was with mixed emotions when they walked in the front door of the house last week for the first time since their hasty departure in December. Scarlett, Tim and mom Neeley Brimer have been staying with Wills at B.C. Childrens Hospital as he was treated.

We came home to all our Christmas decorations still being up, our tree had unfortunately lost all its needles and there were unwrapped Christmas presents still waiting. It was a really happy return but it was also kind of a bit sad, he said. But it has really been good for Wills, coming home is not going to be a miracle cure but it does lift a lot of weight. We hope the happier he is the better it will be for him to fight the cancer itself.

READ MORE: Nine-year-old Penticton boy faces return of lung tumours

The three returned to Vancouver Feb. 25 and Wills was expected to undergo a medical evaluation this week and learn his prognosis.

The family is expecting to get those results from the doctors on Friday at the hospital.

This will be one of those hold-the-breath moments, to see how effective the chemo has been on the remaining tumour they deliberately left in, said Hodgkinson, adding Wills could be in for another four, month-long chemo cycles as well as a stem cell implant.

So were in it for the long haul, we know that, just fingers crossed.

Both he and Brimer, who separated in 2016, have been spending time in Vancouver during treatment, Brimer at the hospital with Wills and Scarlett, who is four-and-a-half years old, and Hodgkinson at Ronald McDonald House.

Both parents had immense praise for the enormous support they have received from friends and the many people they dont even know.

Its incredible, in the best possible way its overwhelming, said Brimer. Im incredibly grateful for where we live and the people that are involved in our community.

Cancer

Tim Hodgkinson with his children, Scarlett, 4, and Wills, 9 at their Naramata home. The family has been in Vancouver since late December for Wills cancer treatments. (Mark Brett - Western News)

Wills Hodgkinson, 9, relaxes on the front porch of his Naramata home after being allowed a break in his cancer treatment in Vancouver. (Mark Brett - Western News)

Wills Hodgkinson takes a break from the drums that he got to play again after returning home from B.C. Childrens Hospital for a few days. (Mark Brett - Western News)

Link:
Brief respite for Wills in cancer battle - Pentiction Western News

Review Finds The Effects Of Obesity On The Body Mirror Those Of Aging – IFLScience

Obesity is a widespread health concern affecting around 1.9 billion adults and 380 million children across the globe, with reports from the World Health Organization (WHO) saying that more people are now dying as a result of being overweight than underweight. Obesity has long been known to cause devastation to vital organs and vessels, but new research published in the journal Obesity Reviews highlights how the changes it causes both to our bodies and on a cellular level reflect those of aging.

Obesity increases your risk of developing diseases thatcan dramatically alter your quality of life or even prove fatal. It can cause compromised genomes that increase your risk of cancer and a weakened immune system, making you sicker more often. It also leads to decreased cognition and increases your chances of developing Alzheimer's disease and cardiovascular disease, alongside a host of other illnesses.

The team reviewed over 200 papers looking at the effects of obesity on one'shealth andcells. Weve known for a while that obesity is linked to premature death, but the review also noted the link between obesity and cell death (apoptosis) and the maintenance of healthy cells (autophagy) two processes thatare known to impact physical aging.

"We are trying to comprehensively make the argument that obesity parallels aging," said lead researcher Sylvia Santosa, a Tier II Canada Research Chair in Clinical Nutrition, in a statement. "Indeed, the mechanisms by which the comorbidities of obesity and aging develop are very similar."

One study on various organs of mice including the heart, liver, and kidneys found that apoptosis was increased in clinically obese subjects. Meanwhile, another paper observed that autophagy, which is the bodys way of clearing out unhealthy cells, was negatively impacted, a consequence thatis strongly linked to the emergence of diabetes, Alzheimers, and cardiovascular disease.

Researchers on the review also found obesity can impact our ability to fight off illness as it speeds up the aging of the immune system by targeting different immune cells. These changes not only negatively impacted the bodys ability to fight sickness but also couldnt be reversed by weight loss at a later time. This means obese individuals are at greater risk of picking up bugs like influenza, which are already known to cause more severe symptoms in significantly overweight individuals.

As well as physical changes to our health and cells, aging can be observed at the genetic level as alterations impact the quality of our chromosomes, making them more likely to code for errors and dysfunctional cells. One such example was the shortening of telomeres protective caps thatwere observed to be 25 percent shorter in obese participants when compared to those of a healthy weight.

Scaling up, the review also found that more tangible issues such as cognitive decline, reduced mobility, and increased hypertension and stress all age-related problems associated with later life were seen in obese participants.

The extensive review came about in response to the rising trend of obese children and young adults developing adult-onset conditions such as high cholesterol, diabetes, and hypertension. In a statement, Santosa said, "I ask people to list as many comorbidities of obesity as they can. Then I ask how many of those comorbidities are associated with aging. Most people will say all of them. I'm hoping that these observations will focus our approach to understanding obesity a little more, and at the same time allow us to think of obesity in different ways.

Find out how human stem cells could hold the key to curing diabetes.

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Review Finds The Effects Of Obesity On The Body Mirror Those Of Aging - IFLScience