What are Stem Cells and How are They Used? – Interesting Engineering

Embark on a deep dive into the cutting-edge field of stem cell research with our latest YouTube video! Stem cells, with their unique ability to renew and differentiate into various cell types, hold the key to unlocking groundbreaking medical treatments. In our video, we explore the science behind these remarkable cells, from their discovery to their potential applications in regenerative medicine.

Discover how somatic stem cells, found in organs throughout the body, play a crucial role in tissue repair and regeneration. Learn about the pluripotent nature of embryonic stem cells, derived from early-stage embryos, and their potential to differentiate into any cell type. We delve into the ethical considerations surrounding the use of embryonic stem cells, as well as the ongoing efforts to overcome challenges such as rejection in transplantation.

Join us as we examine the current state of stem cell therapy, from its successes in treating certain cancers to its potential for revolutionizing the treatment of degenerative diseases like Alzheimers and Parkinsons. Gain insights into the latest research advancements and the future prospects of harnessing stem cells for personalized medicine.

Read the original:
What are Stem Cells and How are They Used? - Interesting Engineering

California Man Free of HIV And Cancer in Astonishing Medical Recovery – ScienceAlert

On the list of illnesses that nobody wants, cancer and HIV both rank pretty high, and Californian man Paul Edmonds had both.

But ever since one particular treatment five years ago, he's been free of both cancer and HIV. The patient is now considered in remission from acute myelogenous leukemia (AML), and in another two years, he could be considered 'cured' of HIV, as that will mark five years from his last treatment.

To celebrate, the medical team behind his astonishing recovery have published a letter describing the case in the New England Journal of Medicine.

The treatment behind the remission is known as a stem cell transplant, or, in medical terms, an allogeneic hematopoietic cell transplantation.

It's used as the final part of treatment for blood cancers like leukemia, myeloma and lymphoma, where the blood-forming stem cells in a patient's bone marrow have been destroyed by radiation or chemotherapy. Healthy blood-forming stem cells from a donor with similar (but not identical) genes are transplanted into the patient, where they can begin to produce cancer-free blood.

In this case, the doctors report, the donated stem cells came with an added benefit: a genetic mutation associated with resistance to HIV-1.

Edmonds had lived with HIV-1 for 31 years before the transplant.

"People were dying within a few years of finding out they were positive," Edmonds said, describing his experiences in San Francisco in the 80s. "A dark cloud was over the city."

He was diagnosed in 1988 with HIV and full-blown AIDS, which at that time, he told the national cancer institute, City of Hope, felt like a death sentence.

Edmonds had been on HIV antiretroviral therapy since 1997, which had effectively suppressed the virus to undetectable levels.

But antiretroviral therapy doesn't cure HIV, so the virus's DNA was ever-present in his immune cells in his blood - that is, until his cancer treatment introduced a different kind of DNA to his system.

The stem cells Edmonds received in his transplant had two copies of a rare genetic mutation called CCR5 delta-3, which makes people who have it resistant to HIV. Only about 1-2 percent of the population have this mutation, but a donor match for Edmonds with the mutation was found via the City of Hope's blood stem cell and bone marrow transplant program.

HIV uses the receptor CCR5 to enter and attack the immune system, but the CCR5 mutation means the virus can't enter through this pathway.

The transplant totally replaced Edmonds' bone marrow and blood stem cells with the donors', and ever since, he's shown no signs of either AML or HIV. He is one of only five people in the world to have ever gone into HIV remission from this treatment.

After the transplant, the HIV DNA that his blood cells once harbored was nowhere to be found. Edmonds agreed, for science's sake, to discontinue his HIV treatment 25 months after the transplant, which would have led to a resurgence of HIV RNA in his blood, if the virus was still present.

"At the time of this follow-up, the patient had been free of HIV-1 infection for 35 months after the discontinuation of antiretroviral therapy," the doctors write.

"This case has shown that older patients who are undergoing reduced-intensity conditioning HCT for the treatment of cancer may be cured of HIV-1 infection."

Stem cell transplants come with substantial risks, so not all people living with HIV will be able to receive this treatment. It's still only viable for those with life-threatening blood cancers, with the possibility of curing HIV as a bonus.

Jana Dickter, a doctor at City of Hope involved in Edmonds' case, hopes others will benefit from this two-for-one treatment in future.

"For those who would benefit from a stem cell transplant to treat their cancer, the idea that they could go into remission from HIV simultaneously is amazing," she says.

The letter was published in The New England Journal of Medicine.

Original post:
California Man Free of HIV And Cancer in Astonishing Medical Recovery - ScienceAlert

Brain Recovery: The Role of Stem Cells in Stroke and Cerebral Palsy Treatments – Corporate Wellness Magazine

In the rapidly evolving field of medical science, stem cell therapy emerges as a beacon of hope for individuals suffering from neurological disorders, particularly stroke and cerebral palsy. This revolutionary approach has the potential to redefine the landscape of treatment options, offering new possibilities for recovery and improvement in quality of life. This article delves into the role of stem cells in the treatments of these conditions, shedding light on the science behind the therapy, its application, and the outcomes that patients can anticipate.

Stem cells are the body's raw materials from which all other cells with specialized functions are generated. Under the right conditions, stem cells divide to form more cells called daughter cells. These daughter cells either become new stem cells (self-renewal) or become specialized cells (differentiation) with a more specific function, such as blood cells, brain cells, heart muscle cells, or bone cells. This unique ability makes them invaluable in repairing damaged tissue and regenerating lost cells, offering therapeutic potential in various medical conditions, including neurological disorders like stroke and cerebral palsy.

Stroke occurs when the blood supply to part of the brain is interrupted or reduced, preventing brain tissue from getting oxygen and nutrients. Brain cells begin to die in minutes. Stem cell therapy for stroke aims to restore the function of damaged brain tissue. The therapy involves transplanting stem cells into the patient's body, where they can migrate to the site of injury, promote the repair of damaged brain tissue, and improve neurological function. Research and clinical trials have shown promising results, with many patients experiencing significant improvements in motor function, speech, and overall quality of life after undergoing stem cell therapy.

Cerebral palsy is a group of permanent movement disorders that appear in early childhood. Signs and symptoms vary among people and over time but commonly include poor coordination, stiff muscles, weak muscles, and tremors. There may be problems with sensation, vision, hearing, swallowing, and speaking. Stem cell therapy offers a ray of hope for individuals with cerebral palsy by potentially repairing damaged brain tissue and promoting the development of new, healthy brain cells. The therapy aims to improve motor functions, reduce spasticity, and enhance the patient's ability to perform daily activities independently.

The process of stem cell therapy involves several steps, starting with the collection of stem cells. The cells can be derived from various sources, including the patient's own body (autologous stem cells) or a donor (allogeneic stem cells). Once collected, the stem cells are processed and prepared for transplantation. The method of delivery can vary depending on the condition being treated but often involves intravenous infusion or direct injection into the affected area.

Following the therapy, patients may undergo rehabilitation and physical therapy to maximize the benefits of the treatment. The goal is to help patients regain lost functions and improve their quality of life. The success of stem cell therapy depends on various factors, including the patient's overall health, the severity of the condition, and the type of stem cells used.

As research into stem cell therapy continues to advance, the potential for treating neurological disorders like stroke and cerebral palsy becomes increasingly promising. Scientists are exploring new ways to enhance the effectiveness of stem cell treatments, including combining stem cell therapy with other rehabilitation techniques and developing more targeted delivery methods.

Moreover, the field of regenerative medicine is expanding, with stem cell therapy at its core. This growth is driven by a deeper understanding of the mechanisms underlying stem cell differentiation and tissue regeneration. As a result, the future holds the potential for even more innovative and effective treatments for a wide range of neurological conditions.

In conclusion, Stem cell therapy represents a frontier in the treatment of stroke and cerebral palsy, offering hope where traditional treatments have been limited. By harnessing the power of stem cells to repair and regenerate damaged brain tissue, this approach provides a path to improved recovery and a better quality of life for patients. As research progresses and clinical applications expand, stem cell therapy stands to significantly impact the field of neurological rehabilitation, making it a key area of interest for patients, healthcare providers, and medical tourists seeking the latest and most promising treatments in the realm of regenerative medicine.

Given his unparalleled expertise and success in treating elite athletes and high-profile individuals, we highly recommend Dr. Chad Prodromos for anyone seeking top-tier stem cell treatment. His work at the Prodromos Stem Cell Institute is at the forefront of regenerative medicine, offering innovative solutions for a range of conditions. To explore how Dr. Prodromos can assist in your health journey, consider reaching out through his clinic's website for more detailed information and to schedule a consultation. visit Prodromos Stem Cell Institute.

More here:
Brain Recovery: The Role of Stem Cells in Stroke and Cerebral Palsy Treatments - Corporate Wellness Magazine

Memory Restoration: How Stem Cells Are Tackling Cognitive Decline – Corporate Wellness Magazine

In recent years, the field of regenerative medicine has witnessed significant breakthroughs, with stem cell therapy emerging as a beacon of hope for various conditions, including cognitive decline. Cognitive decline, characterized by a decrease in memory, decision-making ability, and learning capacity, affects millions worldwide, significantly impacting their quality of life. Traditional treatments have offered limited success, leaving a gaping need for innovative approaches. Stem cell therapy, with its potential to regenerate and repair damaged tissues, is now being explored as a promising solution for cognitive rejuvenation.

Cognitive decline ranges from mild cognitive impairment, often seen as a precursor to more severe conditions like Alzheimer's disease, to the profound loss of cognitive function in advanced neurodegenerative diseases. These conditions not only affect the individual's memory and reasoning but also their ability to perform daily activities, leading to a loss of independence.

Stem cells are the body's raw materials from which all other cells with specialized functions are generated. Under the right conditions, stem cells divide to form more cells called daughter cells. These daughter cells either become new stem cells (self-renewal) or specialized cells (differentiation) with a more specific function, such as brain cells, blood cells, or heart muscle cells. This unique ability makes stem cells ideal for repairing damaged tissue, a potential game-changer in treating cognitive decline.

Recent research has focused on the use of stem cells to treat cognitive decline by targeting the underlying causes of neurodegeneration. Studies have shown that stem cells can be directed to differentiate into neuronal cells, potentially replacing those lost to diseases like Alzheimer's. Moreover, stem cell therapy can help in reducing inflammation and supporting the growth of new blood vessels, which is crucial for brain health.

Numerous clinical trials are underway to evaluate the efficacy of stem cell therapy in cognitive restoration. These studies are exploring various types of stem cells, including mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and neural stem cells (NSCs), for their ability to halt or reverse cognitive decline. Early results are promising, showing improvements in cognitive function, although more research is needed to fully understand the potential and limitations of this therapy.

Despite the enthusiasm, stem cell therapy for cognitive decline faces several challenges. These include understanding the optimal cell type, dose, and administration method, ensuring long-term safety and efficacy, and addressing ethical and regulatory concerns. Nevertheless, the future of stem cell therapy in cognitive health is bright, with ongoing research aimed at overcoming these hurdles and improving the precision of stem cell treatments.

In conclusion, Stem cell therapy represents a frontier in the battle against cognitive decline, offering a glimmer of hope where traditional treatments have fallen short. With its potential to regenerate damaged brain tissue and improve cognitive function, stem cell therapy could revolutionize the treatment of neurodegenerative diseases. As research progresses, it may not be long before stem cell therapy becomes a standard treatment, providing relief to millions of individuals affected by cognitive decline. The journey of stem cells from the laboratory to the clinic is fraught with challenges, but the potential rewards for cognitive health are unparalleled, making this one of the most exciting areas of medical research today.

Given his unparalleled expertise and success in treating elite athletes and high-profile individuals, we highly recommend Dr. Chad Prodromos for anyone seeking top-tier stem cell treatment. His work at the Prodromos Stem Cell Institute is at the forefront of regenerative medicine, offering innovative solutions for a range of conditions. To explore how Dr. Prodromos can assist in your health journey, consider reaching out through his clinic's website for more detailed information and to schedule a consultation. visit Prodromos Stem Cell Institute.

Continued here:
Memory Restoration: How Stem Cells Are Tackling Cognitive Decline - Corporate Wellness Magazine

The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut – EurekAlert

image:

Figure 6.Inhibitory effect of VitD on age- and oxidative stress-related accumulation of supernumerary centrosomes in midgut ISCs.

Credit: 2024 Park et al.

Our study demonstrated that the VitD/VDR [vitamin D/vitamin D receptor] pathway is required for intestinal homeostasis during normal differentiation and aging.

BUFFALO, NY- February 27, 2024 A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 3, entitled, The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut.

Adult stem cells are pivotal for maintaining tissue homeostasis, and their functional decline is linked to aging and its associated diseases, influenced by the niche cells environment. Age- and cancer-related reduction of vitamin D and its receptor levels are well documented in human clinical studies. However, the mechanisms through which the vitamin D/vitamin D receptor (VitD/VDR) pathway contributes to anti-aging and extends life expectancy are not well understood. In this new study, researchers Joung-Sun Park, Hyun-Jin Na and Yung-Jin Kim from Pusan National University and Korea Food Research Institute aimed to determine the protective role of the vitamin D/vitamin D receptor pathway in differentiated enterocytes (ECs) during intestinal stem cell (ISC) aging.

This study aimed to determine the protective role of VitD/VDR in differentiated ECs during ISC aging using the adult Drosophila intestine model.

By utilizing a well-established Drosophila midgut model for stem cell aging biology, the researchers revealed that vitamin D receptor knockdown in ECs induced ISC proliferation, EC death, ISC aging, and enteroendocrine cell differentiation. Additionally, age- and oxidative stress-induced increases in ISC proliferation and centrosome amplification were reduced by vitamin D treatment. In conclusion, this study provides direct evidence of the anti-aging role of the VitD/VDR pathway, involving protecting ECs during aging, and provides valuable insights for exploring the molecular mechanisms underlying enhanced healthy aging in Drosophila.

Our findings suggest a direct evidence of the anti-aging role of the vitamin D/vitamin D receptor pathway and provides insights into the molecular mechanisms underlying healthy aging in Drosophila.

Read the full paper: DOI: https://doi.org/10.18632/aging.205518

Corresponding Author: Joung-Sun Park

Corresponding Email: dreamjs78@pusan.ac.kr

Keywords: Drosophila, vitamin D, vitamin D receptor, anti-aging, intestinal stem cell

Click here to sign up for free Altmetric alerts about this article.

About Aging:

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancerand now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com and connect with us:

Click here to subscribe to Aging publication updates.

For media inquiries, please contact media@impactjournals.com.

Aging (Aging-US) Journal Office

6666 E. Quaker Str., Suite 1B

Orchard Park, NY 14127

Phone: 1-800-922-0957, option 1

###

Observational study

Animals

The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut

7-Feb-2024

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

Read the original here:
The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut - EurekAlert

Dr. Tsambarlis on platelet-rich plasma and shock wave therapy for erectile dysfunction – Urology Times

In this video, Peter N. Tsambarlis, MD, discusses regenerative therapies for erectile dysfunction. Tsambarlis is a urologist with Northwestern Medicine in Chicago, Illinois.

The 2 main regenerative therapies are platelet-rich plasma [PRP] and shock wave therapy. But regenerative therapies is a much bigger group than that; it includes things like stem cell therapy, there are some studies with amniotics, but the 2 that are getting the most energy and the most momentum are PRP and shock wave therapy.

These are extremely popular. Obviously, we practice in Chicago, which is a really big city, and you have a subset of people who do a ton of research, by the looser definition, certainly, and want to know more about these therapies. They usually come in with a specific goal, in my experience. "I want to know about shock wave." "I want to know about PRP and if it's good for me." I try to cater the response to who it is. For example, I don't think there's anyone for whom we have good data that PRP is efficacious. But we know it's safe. But those are 2 important but very different things. Just because something is safe doesn't mean it's the best treatment option. There are just no good data that say that this is going to work for erectile dysfunction. I think that's what we want to focus on here. But certainly, there are wonderful data for PRP in the orthopedic literature. But we're not seeing it in erectile dysfunction, and even less so in things like Peyronie disease, which fall under the sexual health umbrella, but in reality are not what people are coming in for on a regular basis in my clinic. Now, the shock wave, on the other hand is really different. Shock wave has some emerging data that are getting stronger and stronger. It may not be a perfect therapy right now for everybody. And as we start to cater, who are the best candidates? What are the appropriate settings? What are the best machines? We're finding out that there are a subset of ED patients who are benefiting from shock wave, and it is more of a call to research. How do we identify the proper protocol? How do we optimize patient selection to get these things to work? But since we don't exactly know, I don't think it's wrong to offer it in patients for whom you have a reasonable expectation of success, but you have to be really transparent about it. You can't promise the world if you don't have the world to give.

PRP is not ready to be utilized as a treatment. It can be utilized as an experimental, but do it in the setting of an experiment, of a trial, something that's controlled. Shock wave is way further down the road, in my opinion. I think it's a reasonable option, as long as you're transparent about it. But you still have to make sure as a patient that you're getting that therapy from somewhere that has, for example, focal shock waves. A lot of these outside clinics are using radial waves, and we have excellent trade of them that is not useful. Not all shock wave is created equal, and it underscores the importance of going somewhere that you can trust. I think even if this is offered as a therapy, which maybe is associated with some sort of reimbursement, it needs to be somewhere where the data can be tracked. I think there's kind of a gray area - are we at the point where this is ready for primetime and this can be offered? "I'm not sure," is the answer. But there are enough encouraging data that say it is definitely safe and might be efficacious, that I think at least if we're tracking the data, we can provide benefit to some people and then utilize what we learn to help a larger portion.

This transcription was edited for clarity.

Go here to see the original:
Dr. Tsambarlis on platelet-rich plasma and shock wave therapy for erectile dysfunction - Urology Times

U.S. Senators Introduce Bill to Protect Aborted Babies from Medical Experimentation – Daily Citizen

In late January, pro-life senators introduced legislation to protect the human remains of aborted babies from medical experimentation for research purposes.

The bill,S. 3713, is titledProtecting Life and Integrity in Research Act of 2024.

If passed, the measure would prohibit the federal government from funding, approving, or in any way supporting research on aborted babies.

The language of S. 3713 expressly forbids medical research organization to solicit or accept aborted fetal human remains as a research donation.

Senator Cindy Hyde-Smith, chair of theSenate Pro-Life Caucus, is the bills primary sponsor. Seventeen other senators join her ascosponsors.

The law regulating human fetal tissue research is complex. Over the years, federal policy has changed significantly based on the views of each presidential administration.

Currentfederal lawpermits research on fetal human tissue if human embryos are not intentionally created or destroyed for the explicit purpose of research.

According to those statutory stipulations, it is still lawful for taxpayer dollars to fund research on aborted babies if the aborting mothers consent.

Opponents of this practice contend that taxpayers money should not be used to promote unethical research on children.

In apress release, Senator Hyde-Smith called the harvesting and trafficking of aborted babies body parts heinous and unethical.

Proponents tout the possibility of discovering medical advancements by using human fetal tissue, but recentanalysisby the Charlotte Lozier Institute calls that assumption into question.

The reportconcludesthat medical research using ethically non-controversial adult and induced pluripotent stem cells continues to advance in the pursuit of cures and treatments, while embryonic stem cells have largely fallen by the wayside, proving that science does not need to kill in order to cure.

Since 2015, the National Institutes of Healths funding for human fetal tissue research has been as high as $115 million annually. Spending for 2024 isprojectedto be approximately $61 million.

Source: National Institutes of Health

Focus on the Family, asreportedby the Daily Citizen, believes human fetal tissue research requiring the destruction of human beings is a violation of the sanctity of life.

Every human, in every condition from the single cell stage of development to natural death, is made in Gods image and possesses inestimable worth. Our human nature not our size, level of development, environment or functional capacity gives us worth and dignity as human beings. Therefore, devaluing and destroying the life of a human embryo opens the door to the devaluing and destroying any human life.

According to supporters of the legislation, the bill is endorsed by Susan B. Anthony Pro-Life America, Americans United for Life, Catholic Vote, March for Life Action, U.S. Conference of Catholic Bishops Committee on Pro-Life Activities, Students for Life Action, and Concerned Women for America LAC.

A companion measure was introduced in the U.S. House of Representatives last year,H.R. 398, but no action has been taken to advance the legislation.

The Senate bill was referred to the Senate Committee on Health, Education, Labor, and Pensions, where it awaits further action. The Daily Citizen will keep you updated on its progress.

Image from Shutterstock.

See the original post here:
U.S. Senators Introduce Bill to Protect Aborted Babies from Medical Experimentation - Daily Citizen

Stem-Cell Penis Enlargement: Biohackers Increasing the Size of Their Penis – Men’s Health UK

'You might feel a bee sting' was the warning neurosurgeon Marcella Madera gave Shawn Wells as she made the first of six injections deep into the base of his penis.

The biochemist and entrepreneur soon began to breathe heavily from the extreme discomfort, while Madera continued pumping embryonic stem cells extracted from his legs into his manhood. Is it pain or pressure? Madera asked. Both, was the gritted-teeth response from Wells, who had come to the Restorative Medicine Center in Austin, Texas, for the Adonis Experience, a suite of cutting edge, experimental rejuvenation treatments for men that promise penis enhancement and sexual optimisation.

The desire to enhance the look and feel of ones penis

More recently, doctors have been injecting fat so-called penile fillers from patients stomachs into their penises. There have been apparent successes, but many have been left with wonky, deformed cocks rather than the handsome truncheons they craved. Penile implants and lengthening surgeries, equally, have left some men fulfilled and proud, and others flabbergasted and dismayed. In Sweden, in 2017, a 30-year-old man had a heart attack and died just after having fat cells injected into his penis.

But cutting-edge technological advancements are changing whats possible. Stem-cell injections and shock therapy are becoming the means du jour for men seeking to become more content with their penises, and increasing numbers of men claim they help reverse the inevitable effects of ageing while also improving performance.

It's no wonder people are so excited about it all. Half of all men above 40 are affected by erectile dysfunction, or impotence, and as testosterone levels decline, erections lose strength and orgasms become less intense. Im approaching 50; it's important for it to work just as well as it ever has done, says Wells.

Shawn Wells with Dr Marcella Madera.

A year-and-a-half after his own procedure, Wells says his erections are back to full strength, after having softened with age. Sometimes he hadnt even been able to get an erection or would lose it halfway through sex. That's no longer the case. I gained as much as 20% (in length and strength). It literally looks and feels bigger. Enjoyment levels have increased too. When it's more erect, not only are you giving her more pleasure, youre getting more pleasure too, because the more blood flow there is, the more sensation. And certainly, it lasts longer.

According to Wells account, it appears that he has reversed the symptoms of erectile dysfunction that creep up on men as they grey. He has decreased his penile age, after finally getting stem-cell injections in his dick following almost a decade getting them elsewhere in his body to biohack his biological clock back to age 33. After all, what kind of longevity regimen doesn't also make you 'last longer'?

But Wells isnt the only biohacker taking on penile ageing. Bryan Johnson, the tech entrepreneur and poster boy of the longevity movement, uses a wand-like instrument to shock his penis through acoustic technology in an attempt to reverse his aging dick and get the erections of an 18-year-old.

On a Zoom call at the end of January, Johnson told Mens Health that just the week before he had received Botox injections in his penis after reading that it could be beneficial. It increased blood flow, he says. It increased penile length [and gave me] stronger erections.

Johnson, who says he already had ideal penis health when he embarked on this journey, has previously been lampooned by some for sharing how he straps a small sensor device to his penis several nights a month to measure the strength of his erections and ensure his penile age is decreasing. But night time erections are really important indicators of sexual, physiological and cardiovascular health, he says. When I shared this publicly, several of my friends messaged me to say they think they have none. Theyre all signed up with grind culture, Johnson says, and not prioritising sleep, and therefore their cocks arent working properly.

At his last erection-strength reading, the 46-year-old, who famously spends $2m a year to ward off ageing through various means, was erect for about two hours, 12 minutes on average per night, giving him a penile age of just over 30. To reach the level of a late-teen, he would have to be hard for three-and-a-half hours during sleep.

Unfortunately, the contraption Johnson has been using got a bug preventing fresh data capture over the past two months. A new device is on its way, but for him, the jury has already given its verdict. I perform better sexually than I have in my entire life, he says. In terms of penile health, readiness, and desire. Im probably at peak ability.

Johnson believes the unpleasant extracorporeal sound-wave shocks (in pain terms a 7/10 on the shaft, but 9/10 at the tip, he says) that are said to strengthen the pelvic floor where some of the muscles attached to the base of the penis originate were therefore worth it.

But whats the deeper reason behind the drive to de-age the dick? Johnson and Wells have a history of obesity and depression in common and today theyre hungry to make up for time spent not living their current baller lifestyles and to achieve eternal youth. It took me years to remove that internal demon, Johnson has said. I spent most of my life with PTSD, feeling suicidal, and depressed, says Wells.

Both Wells and Johnson spoke at the longevity and psychedelics conference Wonderland, held by the company Microdose, in Miami, at the end of last year. Another of the attendees, Dave Asprey, author and self-proclaimed father of biohacking, gave a talk on the secrets of brain longevity and declared that he intended to live until at least 180. Id like to have a really active sex life as part of that, he says to Men's Health.

Asprey first received stem-cell injections in his penis in 2015, and has since done the treatment several further times. He also has a shockwave machine at home. Doing those and shockwaves three times, I grew about an inch and a half, he reveals.

Asprey says it was not his goal to change the size of his penis, it was more that he routinely tests new biohacking technologies, but he believes he was the first person to talk publicly about biohacking his penis. It's tough to talk about because bragging about your dick size is the douchiest thing you could do So youd have to ask my girlfriend, thats the kind of results you get from it.

Dave Asprey, the so-called father of biohacking, uses a shockwave machine at home. He says it's enabled him to grow about an inch and a half.

The 50-year-old is content with his role spearheading the wave of penile health consciousness, though he is yet to wear the FirmTech ring at night to measure his erectile health and fitness. But Asprey claims that thousands of men have followed his lead and undergone restorative therapies for erectile dysfunction. I would guess that as a result of my podcast, at least 50,000 guys have gone out and done this, he says. I remember one time I told a group of friends at dinner, guys in their 40s to 60s. All of them went out and got it done. A couple of them came back and were like, Damn, yeah, that worked. One of them had the Peyronie's [disease] where it tilts to one side, and it got straightened out.

Dr Shirin Lakhani, the founder of Elite Aesthetics, started offering penis enhancements with blood plasma back in 2014. Stem-cell treatments are far harder to access in the UK due to medical guidelines, and, it has to be said, the greater propensity of British doctors to act in line with the clinical evidence base. Hundreds of clinics across the US offer a variety of stem-cell therapies, while only about 17 places in the UK provide the so-called P-shots. I'd get a handful of enquiries every week to start with, she recalls. Now we're absolutely inundated.

Dr Shirin Lakhani with a P-shot.

About one-in-five of patients that undergo the procedure dont get any improvements, but some get a 25% increase in girth and 20% increase in length for up to a year on average, and sometimes longer, she says. A great deal of importance has been placed on men by society in being able to have intercourse and perform, she says. I find it incredibly rewarding to be able to help. Giving people back their confidence, improving their lives and their wellbeing. It's just part of being a doctor.

However, many experts are concerned that there is not yet enough robust clinical data to support the growing use of these penile revamp therapies. As of January last year, the published papers on stem-cell therapy for erectile dysfunction included studies performed on fewer than 120 men. In a study on 17 men with perpetually flaccid penises, just under half recovered their erectile function thanks to stem cell injections. Subsequently, they were able to accomplish sexual intercourse. A study with 60 men had similar results, while a meta analysis including 12 human studies found that no major complications were reported in any of the trials.

There is also only preliminary research to prove the efficacy of shockwave therapy, which is a common treatment to dislodge kidney stones. A study in the Scandinavian Journal of Urology had 112 male participants, all of whom had erectile dysfunction and were unable to have sex without Viagra which many men do not respond to and even when it works can cause headaches and nausea. After five weekly low-intensity soundwave shocks along their penises, more than half of the test group were having sex again unaided. That compares to 9% of the placebo group. The treatment was christened as a shocking Viagra alternative.

In its most recent position paper on restorative therapies for erectile dysfunction, the Sexual Medicine Society of North America (SMSNA) acknowledged the treatments represent a promising technology, but warned the current published studies are limited and underpowered. Until larger, higher-quality studies are complete, restorative therapies should be reserved for clinical trials and not offered in routine clinical practice, SMSNA said.

Dr Leigh Turner, a bioethics expert from the University of California, says outfits are persistently making bold marketing claims to attract clients without the clinical evidence to back them up, which is a recipe for patients spending considerable amounts of money for little or no chance of clinical benefits beyond potentially transient placebo effects. Im worried about clinics exploiting the hopes, fears, and anxieties of patients, he says. Its very easy to take advantage of vulnerable individuals who are looking for help.

He warns that US businesses currently marketing stem-cell treatments for erectile dysfunction are often not staffed by urologists or other trained specialists. Rather, many such clinics are staffed by individuals that have no meaningful expertise in erectile dysfunction, urology or mens health.

Still, the desire to enhance the look and feel of ones penis has always been a male obsession. Despite the limited data, anecdotal reports of positive benefits make them a worthwhile risk for many. Thats buttressed by the fact that many athletes, including Tiger Woods and Rafael Nadal, have undergone stem-cell treatments on other parts of their body.

UFC bantamweight champion, Sean OMalley.

UFC bantamweight champion Sean OMalley was at a clinic in Mexico in 2022 to get stem-cell therapy to treat a recurring knee injury when he decided on a whim to get the injections in his penis, too. There's one guy there, and he's like, Yeah I'm getting my dick done, he recalled on his podcast. I think he had erectile dysfunction or something, and I'm like, Well, my wiener works perfectly fine. Is there any cons or is it just pros? The doctors told him it could help with girth, performance, explosive orgasms. So I'm like "Well, it ain't the first time I've had a needle in my wiener, hit me up doc." It was painful and there was serious bruising, but he claims his erect penis is now about four-inches bigger.

It was $5,000 well invested for Wells to ensure he could always get a healthy boner, too. His occasional inability to maintain an erection previously would, naturally, disrupt intimate moments and lead to frustration. It impacts your confidence, he says. I really feel Im living my best and most useful life now.

See the article here:
Stem-Cell Penis Enlargement: Biohackers Increasing the Size of Their Penis - Men's Health UK

FDA approves Xolair as first and only medicine for children and adults with one or more food allergies

Basel, 16 February 2024 - Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today that the U.S. Food and Drug Administration (FDA) has approved Xolair® (omalizumab) for the reduction of allergic reactions, including anaphylaxis, that may occur with accidental exposure to one or more foods in adult and paediatric patients aged 1 year and older with IgE-mediated food allergy. People taking Xolair for food allergies should continue to avoid all foods they are allergic to (commonly referred to as “food allergen avoidance”). Xolair should not be used for the emergency treatment of any allergic reactions, including anaphylaxis. Immunoglobulin E (IgE)-mediated food allergies are the most common type and are typically characterised by the rapid onset of symptoms following exposure to certain food allergens.3 Xolair is the first and only FDA-approved medicine to reduce allergic reactions in people with one or more food allergies. Xolair is widely available and can now be prescribed for appropriate patients with IgE-mediated food allergy in the U.S.

Link:
FDA approves Xolair as first and only medicine for children and adults with one or more food allergies