Stem Cell Treatments MI | Michigan Center for Renerative …

How would you like to avoid addictive medications for your chronic pain or progressive disease with a revolutionary, safe and effective alternative? Our own stem cells could provide the answers. Found mainly in our bone marrow and fat, stem cells are powerhouses of healing potential. Imagine being able to use your own stem cells to heal injury! The process itself is relatively simple, which involves isolating the stem cells, concentrating them into a syringe and injecting them where they can do the most good.

Here at The Michigan Center for Regenerative Medicine, we utilize the bone marrow stores over fat for a couple of different reasons. First, they work better for the types of conditions we treat. Second, the FDA restricts techniques aimed at isolating fat cells. Because we pride ourselves on our strict compliance with the FDA, we focus on bone marrow aspiration procedures. Virtually painless, stem cell treatments in Michigan have been used here to successfully treat conditions such as spinal disc herniations, osteoarthritis, tendonitis, bursitis, rotator cuff damage, whiplash, plantar fasciitis and much more.

Tired of pain? Looking to avoid dependence on medication or reduce your chances of surgery? We can help. To find out more, call The Michigan Center for Regenerative Medicine today for your consultation at 248-216-1008.

Stem cell treatments in Michigan carry with them many benefits, not the least of which is to finally incorporate a treatment plan that doesnt simply mask the pain such as through pills and cortisone injections, but that truly addresses the underlying cause.

Stem cell treatments can:

Dr. Thomas S. Nabity, Jr., board-certified in physical medicine, rehabilitation and pain medicine, will conduct the procedure with his team. Harvested cells are isolated in an on-site lab using a centrifuge and flow cytometer to achieve the highest concentration of cells possible.The stem cells are then placed in a syringe and re-introduced into the targeted tissue. This all happens on the same day, performed under either x-ray or ultrasound to ensure precise location for stem cell delivery.The entire procedure takes two hours from start to finish, usually only requiring local anesthetic. However, IV sedation is available if you want it.

Scientifically proven regenerative medicine could be your solution. Every year, more and more patients opt to fix their chronic orthopedic conditions with stem cell treatments over invasive surgery. Are stem cell treatments in Michigan right for you?

We would be happy to provide you with a consultation to answer your questions on stem cell treatments in Michigan. Please call us now at 248-216-1008.

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Stem Cell Treatments MI | Michigan Center for Renerative ...

Treating Serious Injuries With Horse Stem Cell Therapy

Treating injuries in horses, particularly orthopedic injuries, is something which has always been done with difficulty. Every thirdsports horse has a tendon or ligament injury during his career. It takes 9-12 month to heal and 70% of them can not reach the previous results again. A repeated injury also occurs in 66% of cases and scar tissue is formed. Value and the skill level of the horse have also fallen,but not if you choose to treat injuries with horse stem cell therapy.

Of course, horse owners always want to ensure that their animals are receiving the best treatment possible and get back to racing as soon as possible. As a result, many of them are jumping at the opportunity to try stem cells. So lets run through the basics of equine stem cell therapy.

The cells used for the treatment of horse injuries are known as mesenchymal stem cells. These are multipotent stromal cells that can differentiate into a variety of cell types,including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells).There are several ways and methods to get hold of donor stem cells:

These donor stem cells are collected and then grown until there are enough stem cells for treatment. In most cases, this is going to be around 10 million stem cells we see this as the optimal amount to increase the success of the treatment.

Stem cells can be used to treat horse injuries. The greatest success seems to be with injuries to the tendon and ligament.

The proper use of stem cells can help to speed up healing of these areas in horses 3-4 times.

One of the areas where we have seen a lot of success with this treatment is injuries to the Deep Digital Flexor Tendons (DDFT). These tendons help to endure most of the animals weight. This means that if they are damaged, it can cause serious damage to the horse. Damage to these tendons can be tough to treat.

It is believed that using traditional methods of treatment will get the animal fully healed about 29% of the time. Anecdotal evidence seems to suggest that the use of stem cells as a healing method could get the animal back to work 75% of the time.

Medrego experience and cases show even up to 90% of success rate.

Obviously, we do not have a 100% success rate, but having such a high success rate is something which really warrants further research.

There are many ways your horse can injure a muscle even when he is sitting somewhere and you spook him by accident, he can still pull, tear or otherwise injure it.

Its the same as with us, humans. We can injure ourselves in a lot of different ways.

If you are competing with your horse in competitions, then you must know that muscle injury can affect the horses performance. You will see that he is not giving his 100% and is lazy.

That is where horse stem cell therapy comes in.

It treats your horses muscle injury much faster than a standard treatment.

Contact us for more information about how it can treat your horses muscle injury.

Treating your horses injuries will not only make your horse heal faster, but also help your older horse live his days better.

When horses get old, they start to become very lazy and unhappy they dont want to do the things they used to do before.

But with stem cell therapy that can change. Look at that from this point of view would you want to spend all the days in your old age sitting on the couch watching tv all day?

You would not, and the same goes for your old horse he does not want to spend the rest of his life in the barn, but he also does not feel strong enough to do anything else.

Give him that opportunity with stem cell therapy.

Of course, you will have to follow some standard old horse treatment too.

In the future, researchers are considering seeing stem cells assist with helping damaged or diseased organs, dealing with orthopedic disease, or even dealing with laminitis. We are excited to see the impact this will have on stem cell treatment going forward.

Want to order and try the new Stem Cell Treatment for your Horses? Contact us! >>

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Treating Serious Injuries With Horse Stem Cell Therapy

Stem Cell Alopecia Treatment Market Outlook, Growth by Top Company, Region, Application, Driver, Trends and Forecasts By 2026| Verified Market…

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Stem Cell Alopecia Treatment Market Outlook, Growth by Top Company, Region, Application, Driver, Trends and Forecasts By 2026| Verified Market...

Difference Between Adult and Embryonic Stem Cells | Compare …

The key difference between adult and embryonic stem cells is that adult stem cells are multipotent while embryonic stem cells are pluripotent.

Stem cells are a category of cells with the ability to divide and develop into different types of cells in the body. They are distinguished from the normal cells since they divide and renew themselves over a longer period of time. Moreover, they are unspecialized cells with no specific cellular function in the body. They have the potential to differentiate and become specialized cells in the body such as brain cells, blood cells, and muscle cells. Adult stem cells and embryonic stem cells are two types of stem cells.

1. Overview and Key Difference2. What areAdult Stem Cells3. What are Embryonic Stem Cells4. Similarities Between Adult and Embryonic Stem Cells5. Side by Side Comparison Adult vs Embryonic Stem Cells in Tabular Form6. Summary

Adult stem cells are present in differentiated tissues of the body. These tissues include skeletal muscle, liver, pancreas, brain, eye, dental pulp, skin, bone marrow, blood and lining of the gastrointestinal tract. Moreover, adult stem cells remain in these tissues undifferentiated, with continuous self-renewal and producing identical copies of cells throughout the lifetime of the organism. They undergo differentiation into specialized cells of their tissues of origin when needed.

Figure 01: Adult Stem Cells Repair

Hematopoietic stem cells are a type of adult stem cells present in the bone marrow. They are considered multipotent stem cells as they give rise to different types of blood cells from a single type of cells. Regulated gene expression is responsible for these variations in differentiated cells. It is controlled by special types of transcription factors. Also, stem cells present in the brain are multipotent. They give rise to both muscle and blood cells.

Embryonic stem cells are the undifferentiated cells present in the inner cell mass of the blastocyst a hollow ball of cells developed from the zygote after rapid mitosis. Hence, these stem cells are categorized as stem cells present in the early stages of embryonic development.

Embryonic stem cells are pluripotent. Therefore, they give rise to cells of three germ layers endoderm, ectoderm, and mesoderm except the placenta and umbilical cord. Pluripotency distinguishes embryonic stem cells from adult stem cells.

Figure 02: Embryonic Stem Cells

Embryonic stem cells provide valuable assistance as a renewable resource in the study of diseases and for testing of potential therapeutics and drugs. Under defined conditions, embryonic stem cells possess the ability to divide indefinitely.

Adult stem cells and embryonic stem cells are the two main types of stem cells. The key difference between adult and embryonic stem cells is that adult cells are multipotent as they have a limited ability to differentiate while embryonic stem cells are pluripotent as they have the ability to differentiate into any cell type. Also, a further difference between adult and embryonic stem cells is that the embryonic stem cells can readily grow in cell cultures while the growth of adult stem cells in cell cultures is very challenging.

Moreover, a significant difference between adult and embryonic stem cells is that the adult stem cells are present in adult tissues while embryonic stem cells are present in the early development at the blastocyst stage.

The key difference between adult and embryonic stem cells lies in their potency. That is; the adult stem cells are multipotent while embryonic stem cells are pluripotent. Adult stem cells are present in differentiated tissues of the body such as liver, pancreas, skeletal muscle, etc. Regulated gene expression is responsible for variations in differentiated cells derived from adult stem cells. On the other hand, embryonic stem cells are present in the inner cell mass of the blastocyst. These stem cells give rise to the cells of ectoderm, endoderm, and mesoderm. Furthermore, embryonic stem cells divide indefinitely under defined conditions. This is the summary of the difference between adult and embryonic stem cells.

1. The Adult Stem Cell. National Institutes of Health, U.S. Department of Health and Human Services, Available here.2. Stem Cells. A Closer Look at Stem Cells, Available here.

1. Stemcellheartrepair By US gov -(Public Domain) via Commons Wikimedia2. Human embryonic stem cells only A : Human_embryonic_stem_cells.png: (Images: Nissim Benvenisty)derivative work: Vojtech.dostal (talk) Human_embryonic_stem_cells.png (CC BY 2.5) via Commons Wikimedia

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Difference Between Adult and Embryonic Stem Cells | Compare ...

Science Fiction Becoming Reality – Reporter Magazine

by Tyler English | published Dec. 11th, 2019

illustration by Darius Serebrova

Ever wonder where those neon yellow, green, blue and pink fish came from? You know, the ones that have all the matching accessories: tanks, decorations, rocks and their own special ultraviolet light? Well, as it turns out, a team ofscientists in Singapore were the first ones to genetically modify fish to glow in such a way.

Genetic editing in small animals and plants has been aroundsince the 1970s, according to Synthego, a company that providesgeneticallyedited stem cells. Starting with plants and bacteria, scientists began to explore the realm of DNA and genetics. As their understanding of the proteins grew, so did their curiosity.

When scientists learned how to modify the genes of small, simple organisms, they began to wonder, "How could this be applied to humans?"

The scientific community is stirring with the emergence of CRISPR DNA,more specifically known as the CRISPR-Cas9 protein.CRISPR stands forClustered Regularly Interspaced Short Palindromic Repeats.CRISPR is a faster, cheaper and more accurate way of editing the genome, according to theNational Institute of Health.By sending in two different pieces of CRISPR DNA,scientists are able to modify genes. To do so, theycutout areas of genes that aren'tperforming how they should be or as they're expected to.

Dr. Sandi Connelly, a principallecturer in the Thomas H. Gosnell School of Life Sciences, explained how DNA works and what the CRISPRCas-9 protein actually does. Connelly compared DNA to a street of houses each person has different foundations that sprout out different and unique homes.

CRISPR is a piece of DNA, and we [scientists] attach to it an enzyme ...it cuts the DNA at a very specific place like a pair of scissors, Connelly said. When we look at CRISPR, typically we look at CRISPR Cas-9."

Whereas CRISPR is the DNA itself, Cas-9 is the enzyme, a specialized protein that splits the DNA.Connelly said that this allows for both the CRISPR DNA and the original DNA to stick together like magnets. However, due to the specificity of this technique, scientists need to know where in the DNA they'relooking.

Using those same enzymes, we can cut [and] place back inthe good gene, Connelly said.

Now, this technique would not be doneby injecting the CRISPR DNA directlyinto a fully grown adult. Instead,scientists would take a sample of a persons bone marrow and alter the genes of those cells. Since bone marrow is responsible for producing red blood cells, the new altered bone marrow will produce cells with the new DNA.

Connelly saidthechangeswouldnot be instantaneous.The human body replaces a majority of its cells within 13 days, soit would take around two weeks for the newly edited gene to be present in the human body.

The ability to now alter genes of morecomplexorganisms brings with it a variety of applications. Plants can be changed to increase nutritional value and pesticidal properties,whereas bacteria can be used to generate hormones and medicines.

Dr. David Holtzman,an adjunct professor in the College of Science, understands how gene editing is used and what it could be used for.

Most people are familiar with it [gene editing] for things like modifying plants ...[but] there is a lot of misunderstanding about gene editing, Holtzman said.

There is a lot of misunderstanding about gene editing.

CRISPR has begun to work its way into at-home kits, where those with some scientificexpertise can genetically modify their own plants to glow or be a different color. This is fairly simple in the world of gene editing as it is changing a simple expressed trait one that isbiologically shown.

Genes decide what traits a person has, but that persons environment and what happens to their body determines how those traits are expressed. As gene editing becomes more and more innovative, Holtzman said that there are limitations to what gene editing can and cannot do.

It turns out most traits are more than one gene, Holtzman said.

Holtzman used hair color as an example. Numerous genes and sections of DNA code for what an individual's hair colorwill be. Itcan behard and time-consuming to find the right area of the DNA to target for modification.

Connelly talked about the idea of changing hair coloras well,but took it a few steps further. Shesuggestedthat we may start wanting to create offspring that all have blonde hair and blue eyes, which realistically we could accomplish. This then opens parents up to the ideas of having all male children or all female children.

In recent years, science has progressed faster than we could have thought.What appeared to be science fiction in the past is inching ever closer to our scientific reality.

The ability to do [new]things happens a lot faster than our understanding of what we are doing, Holtzman said.

Regardless of the potential scientific progress that could be made, Holtzman, Connelly and other members of the scientific community are having conversations about what should be done with this technology. Where should the limits lie, and how far should humans gowith genetic technology?

"Where should the limits lie, and how far should humansgowith genetic technology?"

If our parents changed our genes, they would also be changing the genes of all of our descendants by extension. Did they consent to something like that?

Some might argue, whether we gene edit or not, we dont really have control over what our parents did, Holtzman said. There is the possibility that if we changed [certain genes]then we can change them back.

Reversal isn't a guarantee, though.

Holtzman mentioned ways in which gene editing could greatly improve the quality of life for all humankind, such as curing Alzheimers disease. Connelly brought up how easy it would be to reduce the effects of aging using genetic modification.

The consequences of the choices made nowmay not affect the generation making them. As the movement to improve the genetic composition of the human race pushes forward,plots in sci-finovelsmay no longer be abstract, distant futures. Rather, for better or worse, they could bethe reality we are setting up for generations to come.

Excerpt from:
Science Fiction Becoming Reality - Reporter Magazine

Thinning Hair? Here are 8 Ways to Make It Fuller and Shinier – Self

It may be a little distressing to notice, possibly for the first time, that you have thinning hair. For many of us, its a natural part of aging that doesnt necessarily need to be treated. But aging is only one of many factors that can cause or exacerbate thinning hairand some of these causes should be addressed.

Once you know whats causing the issue, it becomes a lot easier to figure out how to manage it. Below, SELF talked to several experts about ways to make your hair feel thicker and look shinier, as well as ways to prevent more hair thinning.

The first thing to know about hair loss is that its actually a bit complex. Your hair grows in three stages, SELF explained previously. These include a growth phase from a root in the hair follicle, a transitional phase when the growing stops, and a resting phase, after which the hair falls out and the follicle takes a break before growing another hair.

Its totally normal to lose between 50 and 100 hairs a day, according to the American Academy of Dermatology (AAD), which you might notice on your pillow in the morning, on your hairbrush, or in the shower. If you go a few days without showering, you might notice more than a single days worth of hair in the shower, which may be a little disconcerting, but is still totally normal.

Youre born with about 100,000 follicles on your scalp, and youll never gain or lose any, the AAD says. However, as you age, some follicles may stop growing hair and you may experience hair loss (also called anagen effluvium). When and how this happens is influenced by a bunch of factors, including our genetics and the natural hormonal changes we experience as we age, Shilpi Khetarpal, M.D., dermatologist at Cleveland Clinic, tells SELF.

But you might also experience hair shedding at certain points in your life, a process thats separate from hair loss. Hair shedding (also called telogen effluvium) is more often caused by temporary changes in hormones, like giving birth, stopping hormonal birth control, or experiencing life stressors, like undergoing chemotherapy or recovering from a serious illness. Nutritional deficiencies, harsh hair products, and certain hair styles can also cause hair shedding, the AAD says.

If your hair is shedding, that means its falling out more quickly than it should be because its being shoved into the resting phase too early, SELF explained previously. But if youre experiencing hair loss, that means theres something stopping the hair from growing in the first place. And, because hair loss can be caused by different factors, its important to figure out which one youre dealing with before trying to treat it.

If you dont know if your thinning hair is due to hair shedding or hair loss, you should check in with an expert. Its also important to talk to a dermatologist if youre losing more than 100150 hairs per day or you notice other issues (bald spots, hair shafts that break easily, or an itchy or burning scalp), Alina G. Bridges, D.O., dermatologist and dermatopathologist at the Mayo Clinic, tells SELF. These could signal a more serious hair-loss issue or an underlying condition (like scalp psoriasis) that warrants professional treatment.

If youre not sure how many hairs youre losing in a single day (understandable) you can test it with the 60-second hair count: Comb your hair forward from the back of your head to the front for a full minute. Collect and count the hairs that were shed through this processyou should see between 10 and 20 strands, depending on your age. If you see more than that, you might be dealing with some excess hair loss. To get the most accurate idea of how many hairs youre losing, you might want to do this a few days in a row.

Once you know what youre up against, there are some easy ways to help manage thinning hair at home or with the help of an expert. Here are the top tips we learned from dermatologists and hair stylists on how to protect your hair and restore some of its fullness and shine.

You likely dont need to wash your hair every day. In fact, Samantha DelaFuente, a stylist at Marie Robinson Salons in New York and Miami, tells SELF that she recommends washing only two or three times a week. Dont be afraid of dirty hair, she says.

And dermatologists agree: Washing too often strips your hair of necessary oils, and washing infrequently can leave hair dull and limp, especially if you overuse dry shampoo, Dr. Bridges says. If you have natural hair, which tends to be drier and more prone to breakage, clean it even less frequently, Dr. Khetarpal says.

Moisturizing shampoos formulated without sulfateschemicals in shampoos that help clean but can also be drying on sensitive or dry scalpsare a safe bet for everyone. In particular, celebrity stylist Tym Wallace tells SELF he recommends Oribe Gold Lust Repair & Restore Shampoo ($154, Bloomingdales or Moroccanoil Moisture Repair Shampoo ($24, Nordstrom).

Conditioner gives your hair shine and reduces static electricity, the AAD explains, which is why it improves the look and feel of dull or damaged hair. Apply to the ends of the hair and work your way up, DelaFuente says. A little goes a long way; the more conditioner you use, the flatter your hair will be.

Remove tangles with a wide-tooth comb and rinse with cool water, which closes the cuticle and makes the hair shiny, Dr. Bridges explains.

If youre looking for conditioners that can specifically help dull or thinning hair, Eric Leonardos, stylist at Ted Gibson, tells SELF he recommends Klorane Gel Conditioner with Peony ($20, Ulta), which contains soothing and hydrating ingredients, or Shu Uemura Muroto Volume Conditioner ($58, Shu Uemura), which has a lightweight formula that wont weigh down hair.

After shampooing and conditioning, try using a leave-in product, like a conditioner or detangler, which will boost moisture and provide heat protection before styling.

Wallace recommends the moisturizing and protecting Its a Ten Miracle Leave-In Conditioner Spray Product ($38, Ulta) as well as the truly multitasking Form Multitask 3-in-1 Leave-in Lotion ($32, Form Beauty).

Once a week, apply a deep conditioning mask for extra moisturizing powers, and leave on for 1520 minutes, Dr. Bridges says. Finish by rinsing with cool water.

Leonardos recommends LOreal Elvive Total Repair 5 Damage-Erasing Balm, which he says lends shine and smooths the hair cuticle ($8, Amazon), and Shu Uemura Ultimate Reset Hair Mask, which he explains imparts a smooth texture and smells divine ($68, Sephora).

DelaFuente swears by Milbon Plarmia Hairserum Treatment ($35, Amazon), which comes in formulas for fine-to-medium and coarse hair, and Christophe Robin Regenerating Mask With Prickly Pear Seed Oil ($71, Sephora), a product thats made without parabens and sulfates, which may be irritating to some sensitive scalps.

On his clients, Wallace uses Moroccanoil Restorative Hair Mask ($43, Amazon), made with moisturizing argan oil and shea butter, or Its a Ten Miracle Hair Mask ($32, Ulta), which is designed to nourish color-treated, heat-styled hair.

Rub a small amount of serum through your wet hair before styling or air-drying. In addition to adding shine and combating fly-aways, these products help to prevent frizz.

Wallace recommends Paul Mitchell Smoothing Super Skinny Serum ($21, Ulta), which also helps speed up the drying process, while DelaFuente swears by Alterna Haircares CAVIAR Anti-Aging Restructuring Bond Repair 3-in-1 Sealing Serum ($38, SkinStore), especially for damaged or drier hair.

As an alternative, oilssuch as argan, coconut, and jojobaprovide similar benefits as serums, but actually penetrate deeper into the hair, Dr. Bridges says. They can be applied to wet hair or to dry hair as an anytime treatment or shine enhancer. Leonardos recommends the custom hair oils from Prose ($48).

If styling with a hot tool, do your best to limit heat to a maximum of about 400 degrees Fahrenheit for normal hair, 390 degrees for color-treated, and 350370 degrees for fine, processed hair to avoid causing damage, Dr. Bridges says. Not all heat tools have temperature readingsor the ability to change the temperature, so it may be worth investing in a tool that does have those options if you heat style frequently, such as the CHI Temperature Control Hairstyling Iron ($100, Ulta) or Harry Josh Pro Tools 2-in-1 Ceramic Marcel Curling Iron ($185, Dermstore).

To get a little more lift, try applying volumizing root spray to your roots, then lightly adding mousse to the mid-lengths and ends, Leonardos suggests. In particular he recommends wallet-friendly VERB Volume Spray ($18, Amazon) or, for a longer-lasting option, Oribe Maximista Thickening Spray ($39, Dermstore).

For mousse, DelaFuente swears by Alternas Bamboo Volume Weightless Whipped Mousse ($22, Ulta), which provides long-lasting hold without making hair feel crunchy. And Wallace likes Big Sexy Hair Root Pump Spray Mousse ($19, Ulta). This product actually comes out of the can as a spray and then transforms into a mousse, which might make it a little easier to work with.

Then blow-dry at the roots, using hot or Velcro rollers, to add more volume and set the style. Finish with cool air and a texture spray, such as SGX NYC the Do-It-All 3-in-1 Dry Texture Spray ($9, Amazon), which Leonardos says lends a natural, matte texture; for a longer-lasting option without product build-up, try Oribe Dry Texturing Spray ($46, Dermstore). DelaFuente prefers Milbons Thickening Mist 4 ($26, Amazon), which she says doesnt leave hair feeling stiff or sticky.

One particular type of hair losstraction alopeciais caused by chronic stress on the hair follicle, often due to too-tight hair styles, and its especially common among black women. But if you can treat traction alopecia early on, you can adjust your habits and keep the condition from worsening; in fact, you can prevent hair loss from becoming permanent.

In particular, make sure youre not wearing hairstyles that pull on the scalplike high, tight ponytails, braids, or dreadsfor extended periods of time.

If changing up your styling habits hasnt helped, then it may be worth trying one of two daily-use OTC treatment options. The first one, minoxidil, is available in liquid or foam form at 2% and 5% concentrations, Dr. Bridges says.

This medication prolongs the growth phase of hair, she says, which prevents any more hair loss and may also stimulate new hair growth. However, be prepared to wait: Youll have to use minoxidil daily for at least four months before seeing any effects. And when you stop using it, any new hair is likely to just fall out. Also, its important not to use this if youre pregnant or nursing.

As an alternative, you can try hair-growth products containing a combination of redensyl, capixyl, and procapil (RCP), ingredients that are thought to target hair follicle stem cells, Dr. Bridges says. A study published earlier this year looked at the effects of RCP and minoxidil in 120 men with hair loss over 24 weeks. The results showed that those who received RCP treatment had significantly more improvement in their hair during the study compared to the minoxidil group. However, its not clear how well these results would translate to women or if the over-the-counter products out there containing these ingredients would stack up to those used in the study.

In some cases, youll need a dermatologists help to diagnose and manage your thinning hair. As we mentioned previously, thats especially true if you think you may be dealing with an underlying health condition or if you have specific symptoms, like bald spots or itchiness.

Depending on the root cause of your hair issues, your derm may recommend prescription medications, including birth control pills and spironolactone, Dr. Khetarpal says. These options can target hormone-related hair loss.

For a pricier, in-office approach, you could try platelet-rich plasma (PRP) scalp injections, which generally require repeated treatments that may cost around $1,000 per session. With this method, doctors draw blood, separate out the platelets, and then inject these platelets into the scalp. Platelets may help stimulate hair growth thanks to the growth factors they contain, Dr. Khetarpal says. But so far scientific evidence supporting PRP for this use has been mixed. For instance a double-blind study published in Dermatologic Surgery in 2016 found that more patients who received PRP for hair loss reported a substantial improvement in their hair loss and hair thickness compared to those in the placebo group. However, laboratory testing didnt find any significant difference between the results of those receiving PRP and those who got the placebo treatment.

Healthy hair requires adequate nutrients, especially things like vitamin D and biotin (vitamin B7). So if you think your hair loss could be due to an underlying nutritional deficiency, check with your doctor for a blood test. They may recommend supplementing with specific forms of the vitamins, Dr. Khetarpal says.

There are other serious conditions that can contribute to hair loss, including autoimmune disorders and nutritional deficiencies. If youre not sure whats causing your hair loss or you havent had any success with these other tips, its important to check in with a dermatologist to figure out whats going on.

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Thinning Hair? Here are 8 Ways to Make It Fuller and Shinier - Self

Former Kansas congressman assists with release of U.S. prisoner in Iran – The Garden City Telegram

Former U.S. Rep. Jim Slattery parlayed decades of international relationship-building to assist with gaining freedom of a Chinese-American captive and the release of an Iranian accused of violating trade sanctions.

Slattery, who served an eastern Kansas district in the U.S. House for more than a decade, worked as an attorney and consultant after leaving Congress. He forged relationships along the way that included Majid Ravanchi, a former University of Kansas student now serving as Irans ambassador to the United Nations. In an interview Monday, Slattery said he also was familiar with Iran Foreign Minister Mohammad Javad Zarif.

He contributed to dialogue that led to exchange of Xiyue Wang, a Princeton University doctoral student arrested in Tehran during a research trip, accused of being a spy and incarcerated the past three years, for Massoud Soleimani, an Iranian researcher held since 2018 in the United States on charges of breaking U.S. trade sanctions.

"Bottom line is two families are reunited," Slattery said. "One in Iran and one in Princeton, New Jersey."

On Saturday, the administration of President Donald Trump confirmed the brokered agreement would result in release of Soleimani and Wang. The president said in a statement freeing Americans was of vital importance to his administration and "we will continue to work hard to bring home all our citizens wrongfully held captive overseas."

Slattery, a Democrat engaged for 15 years in outreach projects in Iran, said he was invited to participate by Wang's family attorney. Slattery said he worked pro bono on the project, and told Zarif, the Iranian foreign minister, during a September meeting in New York there was no credible evidence Wang was engaged in espionage.

"I was completely convinced he was not a spy and completely convinced he was being held on bogus charges," Slattery said.

Wang was taken into custody in 2016, convicted on two counts of espionage and sentenced to 10 years in prison in Tehran.

The former Kansas congressman also concluded the U.S. Department of Justice had a weak case against Soleimani, a stem-cell researcher arrested after invited by the Mayo Clinic to come to Minnesota.

The case against him involved exportation of a growth factor used in research to Iran, but Slattery said Soleimani's lawyers could have convincingly argued in court the material was covered by a medical exception to the trade ban.

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Former Kansas congressman assists with release of U.S. prisoner in Iran - The Garden City Telegram

By turning stem cells into brain cells, Aspen Neuroscience hopes to rewind the progress of Parkinson’s disease – FierceBiotech

The idea of a cell therapy for Parkinsons disease starts out simple: Symptoms of the progressive disease are largely driven by the deaths of dopamine-producing neurons found deep within the brain. With lower levels of the neurotransmitter come the characteristic tremors, rigidity and slow movements.

By replacing those lost nerve cells with new dopamine producers, researchers hope to renew the brains connection to the bodys muscles and improve a persons overall motor function.

But in the brain, everything becomes more complicated. On top of the risk of immune system rejection that comes with any kind of living tissue transplant, its important to make sure the implanted cells function correctly and do not pick up any dangerous genetic mutations as they grow.

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Now, a new company, Aspen Neuroscience, aims to tackle both obstacles at once.

First, the startup hopes to avoid any harmful immune reactions by using a patients own cells as a starting point. Then, Aspen plans to implement a rigorous quality control program employing whole genome sequencing and artificial intelligence to make sure the cells stay in line as theyre processed and readied for the procedure.

And to do it, the San Diego-based company is starting out with $6.5 million in seed money plus an impressive roster of names.

They are led by neurology researcher Howard Federoff, previously vice chancellor for health affairs and CEO of the University of California, Irvine health system as well as the executive dean of medicine at Georgetown University. Hes joined by Aspen co-founder and stem cell scientist Jeanne Loring, founding director and professor emeritus of the Center for Regenerative Medicine at the Scripps Research Institute.

Meanwhile, the seed round was led by Domain Associates and Axon Ventures with additional backing from Alexandria Venture Investments, Arch Venture Partners, OrbiMed and Section 32.

Aspen looks to combine its expertise in stem cell biology, genomics and neurology to offer the first autologous cell therapy for Parkinsons diseasewhile others in the space have pursued allogeneic routes, or therapies derived from donors other than the patient.

The process starts with a culture of the patients skin cells, which are then genetically induced to become pluripotent stem cellsor cells capable of differentiating into any other cell type in the body. These are then chemically nudged further to transform into precursor versions of the dopamine-producing neurons, which are typically found in the midbrain and regions responsible for the movement of limbs.

We can say without any equivocation that we can produce the population of cells necessary to transplant, and in a short enough period of time to have a potential beneficial impact on the evolution of the disease, said Federoff, who has also served as chair of the NIHs Recombinant DNA Advisory Committee and helped lead the U.S. Parkinsons Disease Gene Therapy Study Group.

We envisage that this will set back the clock on patients who have Parkinsons, unlike any other therapy that we know of, he told FierceMedTech in an interview.

The number of cells needed would be much smaller compared to other cell therapies and cancer treatments. The healthy human brain contains only about 200,000 dopamine-producing nerve cells, split between its two hemispheres, while patients with Parkinsons disease have lost about 50% or more of those neurons.

Aspen aims to evaluate two doses: one that aims to replace about 60% to 65% of a persons normal cell complement and another larger treatment, Federoff said.

Those smaller doses, as well as starting with a patients donor cells, help make the treatment safer to produce by requiring fewer steps. Each cycle of cell division and multiplication to increase their numbers carries the risk of introducing genetic mutations.

As the cells are grown, they are consistently evaluated with data-driven techniques pioneered by Lorings laboratory. Using whole genome RNA sequencing, Aspen will match the cells up at every stage with a genetic barcode taken from each patient at the start. This will allow them to look for changes, duplications or deletions in the pluripotent stem cell genome.

If the cells harbor mutations that are cancer drivers, we don't want to put those into people, Loring said. The only way is to check the sequencing before we transplant them.

The cells used in the transplant procedure arent fully grown; as neuron progenitors, they mimic the development steps seen in the brain of a growing fetus after theyre placed in the body as they wire themselves up to other neural structures and begin to form new networks of their own.

We anticipate that they will manufacture and release dopamine in a manner that is consistent with synaptic neurotransmission and the process of communicating from cell-to-cell, said Federoff. They will take up dopamine from synapses when it has done its business, bring it back into the cell, and prepare it for another synaptic release.

These are not just dopamine pumps, theyre real neurons, added Loring. They will genuinely replace the cells that have been lost in every way.

Aspen plans to pursue two courses of therapy, for the two major types of Parkinsons disease. Their lead candidate is for idiopathic, or sporadic Parkinsons, while their second is a CRISPR-edited version of the therapy designed to address one of the diseases most common genetic mutations, linked to about 5% of cases.

This would not only aim to restart dopamine production in this orphan indication, but also restore the damaged enzyme GBA, which is seen as an underlying cause. Federoff and Loring expect their sequencing-based quality check system will also help catch any off-target edits linked to the use of CRISPR-Cas9.

The company has yet to secure permission from the FDA to officially launch clinical trials, but the agency has signed off on Aspens plans to prepare a trial-ready cohort of Parkinsons disease patients in the meantime. This would include the initial stages of recruitment and testing, including the selection of patients capable of having their skin cells made into pluripotent stem cells.

After it receives its go-ahead from the FDA, Aspen plans to hit the ground running,enrolling at least 176 participants in a phase 1/2 study that includes a randomized stage to determine clinical benefits.

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By turning stem cells into brain cells, Aspen Neuroscience hopes to rewind the progress of Parkinson's disease - FierceBiotech

SelectScience Interview: Regenerative medicine technique development and the importance of cooperative research – SelectScience

Learn how a new imaging center in South Korea is working to overcome existing experimental limitations with hopes to improve quality of life for cancer patients

SelectScience talks with Eunsoo Lee, Director of Research Support at Ewha Womans University Fluorescence Core Imaging Center, about its work on the observation and regulation of the microenvironment of cancer cells as it seeks to fine-tune tissue-specific methods. Here, Lee highlights the teams focus on designing and supporting experiments that require cooperative research and reveals a key technology underpinning its work.

Our center is still new, having opened just last month. It provides a variety of imaging systems to support the observation of cellular activity/the proteins and morphology of tissue samples. There is a research scientist in charge of each device to offer analytical services. I work on designing and supporting research experiments that require joint/cooperative research.

We are currently involved in research about the regulation of the microenvironment of cancer cells, as well as studying the regulation of reactive oxygen species (ROS) by organelles to determine the role and mechanisms of ROS. My personal research is to investigate the effects of tissue-specific extracellular matrix proteins on cell differentiation.

We are developing new experimental methods to control the microenvironment or control the levels of ROS freely, with the goal of further subdividing and fine-tuning them into organelle- and tissue-specific methods. For cell differentiation experiments using extracellular matrix proteins, we have developed a new method to secure tissue-specific extracellular matrix proteins and are looking to determine whether culturing stem cells in these proteins cause them to differentiate into the respective tissues cells. In this way, we try to overcome the existing experimental limitations by developing new techniques optimized for our research.

We frequently use both the LUNA-FL Dual Fluorescence Cell Counter and X-CLARITY Tissue Clearing System from Logos Biosystems - we keep the LUNA-FL where we culture our stem cells, and it is used for the qualitative and quantitative analysis of cells at each passage.

Ewha Woman's University Fluorescence Core Imaging Center

When studying the differentiation of stem cells according to their location in the brain, we have to isolate six regions of the brain and extract stem cells from each region. When using the traditional method to count cells, it is not only time consuming, but cell quality also slowly deteriorates over time. Using the LUNA-FL makes it possible to get stem cell counts from all six regions quickly while checking cell quality at the same time. Because of this, we can use a similar standard of cells every time, making our experiments more reliable.

Yes, Logos Biosystems products are generally designed with customers in mind and have the advantage of being very easy to use and fast. When it comes to the LUNA-FL, it is especially convenient that, after it counts the cells, there is a dilution calculator for subsequent experiments, and live/dead ratios that need to be recorded can be reviewed directly on the LUNA-FL. Lastly, I think most consumers would choose a product with an attractive design when considering similarly priced devices.

Early next year, Logos Biosystems will launch the newest member of the LUNA family, designed to build on the success of its predecessors: the LUNA-FX7 Automated Cell Counter.

As my research is mainly focused on using tissue scaffolds to study recellularization and tissue-specific cell differentiation, I am hopeful about this ultimately leading to the development of implants that can be used for patients. The development of tailored, purpose-specific functional scaffolds would be a huge contribution to improving patient quality of life in the field of regenerative medicine.

Do you use Logos Biosystems products in your lab? Write a review today for your chance to win a $400 Amazon gift card>>

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SelectScience Interview: Regenerative medicine technique development and the importance of cooperative research - SelectScience

Mechanism may have therapeutic bone healing applications – Baylor College of Medicine News

Periosteal stem cells are major contributors to bone healing

The researchers discovered specific markers for periosteum stem cells in mouse models. The markers identified a distinct subset of stem cells that contributes to life-long adult bone regeneration.

We also found that periosteum stem cells respond to mechanical injury by engaging in bone healing, Park said. They are important for healing bone fractures in the adult mice and, interestingly, their contribution to bone regeneration is higher than that of bone marrow stem cells.

In addition, the researchers found that periosteal stem cells also respond to inflammatory molecules called chemokines, which are usually produced during bone injury. In particular, they responded to chemokine CCL5.

Periosteal stem cells have receptors molecules on their cell surface that bind to CCL5, which sends a signal to the cells to migrate toward the injured bone and repair it. Deleting the CCL5 gene in mouse models resulted in marked defects in bone repair or delayed healing. When the researchers supplied CCL5 to CCL5-deficient mice, bone healing was accelerated.

The findings suggested potential therapeutic applications. For instance, in individuals with diabetes or osteoporosis in which bone healing is slow and may lead to other complications resulting from limited mobility, accelerating bone healing may reduce hospital stay and improve prognosis.

Our findings contribute to a better understanding of how adult bones heal. We think this is one of the first studies to show that bone stem cells are heterogeneous and that different subtypes have unique properties regulated by specific mechanisms, Park said. We have identified markers that enable us to tell bone stem cell subtypes apart and studied what each subtype contributes to bone health. Understanding how bone stem cell functions are regulated offers the possibility to develop novel therapeutic strategies to treat adult bone injuries.

Other contributors to this work include Laura C. Ortinau, Hamilton Wang, Kevin Lei, Lorenzo Deveza, Youngjae Jeong, Yannis Hara, Ingo Grafe, Scott Rosenfeld, Dongjun Lee, Brendan Lee and David T. Scadden. The authors are affiliated with one of the following institutions: Baylor College of Medicine, Texas Childrens Hospital, Pusan National University School of Medicine and Harvard University.

This study was supported by the Bone Disease Program of Texas Award and the Caroline Wiess Law Fund Award, the NIAMS of the National Institutes of Health under award numbers 1K01AR061434 and 1R01AR072018 and U54 AR068069 and the NIDDK of the NIH.

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Mechanism may have therapeutic bone healing applications - Baylor College of Medicine News