Stem Cell Clinic

BioRestorative Therapies Featured in IEEE Pulse Magazine’s Cover Story About Stem Cell Therapies for Low Back Pain – GlobeNewswire

MELVILLE, N.Y., Dec. 16, 2019 (GLOBE NEWSWIRE) -- BioRestorative Therapies, Inc. (BioRestorative or the Company) (OTC: BRTX), a life sciences company focused on stem cell-based therapies, announced today feature coverage in the news outlet, IEEE Pulse, a magazine of the IEEE Engineering in Medicine and Biology Society. According to IEEE, it is the worlds largest technical professional organization for the advancement of technology.

To view the IEEE Pulse Magazines article featuring BioRestorative, click here.

The published cover-story article features commentary from Francisco Silva, Chief Scientist and Vice President of Research and Development for BioRestorative, regarding BRTX-100, the Companys lead therapeutic candidate for chronic lumbar disc disease. Once the U.S. Food and Drug Administration (FDA) authorizes the sale of BRTX-100, we would ship it to your doctor, and with a 30-minute procedure the material would be injected into your disc in a 1.5 ml solution, explains Silva. He elaborates on the product, discussing growing and expanding stem cells from the patients bone marrow under hypoxic conditions that mimic those in the normal intervertebral space. We are enriching the cells to be able to survive in this harsh environment, says Silva.

In addition to BRTX-100, the magazine article also highlights BioRestoratives other research pursuit, its ThermoStem program, utilizing brown adipose (fat) derived stem cells to target treatment of metabolic diseases and disorders, like diabetes, obesity and hypertension.

About BioRestorative Therapies, Inc.

BioRestorative Therapies, Inc. (www.biorestorative.com) develops therapeutic products using cell and tissue protocols, primarily involving adult stem cells. Our two core programs, as described below, relate to the treatment of disc/spine disease and metabolic disorders:

Disc/Spine Program (brtxDISC): Our lead cell therapy candidate, BRTX-100, is a product formulated from autologous (or a persons own) cultured mesenchymal stem cells collected from the patients bone marrow. We intend that the product will be used for the non-surgical treatment of painful lumbosacral disc disorders. The BRTX-100 production process utilizes proprietary technology and involves collecting a patients bone marrow, isolating and culturing stem cells from the bone marrow and cryopreserving the cells. In an outpatient procedure, BRTX-100 is to be injected by a physician into the patients damaged disc. The treatment is intended for patients whose pain has not been alleviated by non-invasive procedures and who potentially face the prospect of surgery. We have received authorization from the Food and Drug Administration to commence a Phase 2 clinical trial using BRTX-100 to treat persistent lower back pain due to painful degenerative discs.

Metabolic Program (ThermoStem): We are developing a cell-based therapy to target obesity and metabolic disorders using brown adipose (fat) derived stem cells to generate brown adipose tissue (BAT). BAT is intended to mimic naturally occurring brown adipose depots that regulate metabolic homeostasis in humans. Initial preclinical research indicates that increased amounts of brown fat in the body may be responsible for additional caloric burning as well as reduced glucose and lipid levels. Researchers have found that people with higher levels of brown fat may have a reduced risk for obesity and diabetes.

Forward-Looking Statements

This press release contains "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and such forward-looking statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause future circumstances, events or results to differ materially from those projected in the forward-looking statements as a result of various factors and other risks, including, without limitation, whether the Company will be able to consummate the private placement and the satisfaction of closing conditions related to the private placement and those set forth in the Company's Form 10-K filed with the Securities and Exchange Commission. You should consider these factors in evaluating the forward-looking statements included herein, and not place undue reliance on such statements. The forward-looking statements in this release are made as of the date hereof and the Company undertakes no obligation to update such statements.

CONTACT:Email: ir@biorestorative.com

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BioRestorative Therapies Featured in IEEE Pulse Magazine's Cover Story About Stem Cell Therapies for Low Back Pain - GlobeNewswire

UCSF’s 11 Most Popular Health and Science Stories of 2019 – UCSF News Services

New technologies that could soon diagnose Alzheimers and restore speech to the paralyzed; potential new avenues in treating diabetes, multiple sclerosis and Down syndrome; and a genetic test that dramatically saved a babys life these were among the science and health topics that most engaged our readers in 2019.

Look back at these 11 stories of the past year or discover them for the first time they reflect the exciting, transformative research that takes place at UC San Francisco every day of the year.

Researchers trained a machine-learning algorithm on nearly 2,000 brain scans and then challenged it to detect early-stage Alzheimers disease in other scans. The algorithm performed with flying colors, catching the disease six years before a clinical diagnosis a lead time that may eventually help doctors treat the disease.

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For California, a 1 percent drop in the smoking rate could mean $630 million of Medicaid savings the following year. Thats because quitting smoking can reduce many health risks relatively quickly, including heart attacks, lung disease and pregnancy complications, as well as cut long-term health risks such as cancer.

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For the first time, researchers were able to transform human stem cells into mature insulin-producing cells similar to the pancreatic beta cells destroyed by type 1 diabetes. The breakthrough came after the team applied a key tenet of biology, that form follows function, to the way they were growing the cells in the lab.

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Researchers took a new approach to studying Down syndrome focusing on the conditions effect on the protein-making machinery inside cells. In a mouse model of Down syndrome, they found that cells in the brain were tamping down on protein production, leading to cognitive deficits. They were able to activate protein production and improve memory and learning with a drug called ISRIB.

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A sophisticated brain-machine interface could one day give voice to people who have lost the ability to speak due to paralysis or other neurological damage. Researchers first mapped participants brain activity to their vocal tract movements as they made various sounds. An algorithm could then translate new brain activity into movements of the virtual vocal tract and produce realistic speech.

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Whats the best way to eat your vegetables? Should you take supplements? Low-fat, low-carb, intermittent fasting do any diets actually work? Experts weigh in on the latest science behind healthy eating and separate food fact from food fiction. Keep these evidence-based tips in mind for the holidays and in the years to come.

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Baby Quincy was deteriorating fast from an aggressive blood cancer and too sick to undergo a stem cell transplant, his only chance at a cure. Determined to leave no stone unturned, Quincys doctors ordered the UCSF500 a new comprehensive cancer gene panel test that helped to reveal an unusual genetic alteration in his cancer and identified a long-shot therapy.

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Multiple sclerosis (MS) is an autoimmune disease caused by immune cells that attack the protective coating around nerve cells. In a surprise, researchers discovered that other immune cells in the gut, known as plasma cells, can reduce the brain inflammation that results from the disease. Expanding these gut plasma cells may be a new therapeutic approach to treating MS.

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Cooking food changes not only how it tastes but how our gut microbial ecosystems respond. In mice, researchers found that cooked vegetables altered their gut microbiome and caused them to lose weight. In human participants, three days of raw or cooked diets prepared by a professional chef also changed gut microbiomes, but in different ways perhaps holding clues to how our microbes have adapted to human culinary culture.

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Alcohol-associated liver disease has become the top reason for U.S. liver transplants, making up more than one-third of liver transplants in 2016. The increase is largely due to a shift away from a common rule that required patients to abstain from alcohol and drug use for at least six months prior to transplant. A 2011 study found that transplants could be successful without this minimum sobriety period, changing the policy at many centers.

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The emotional tumult of teenage years may in part be due to transformations in the brain. Most human brain cells mature in the first years of life, but a group of neurons in the amygdala, which controls emotional responses, dont mature until adolescence and a small number remain immature throughout life. The brain may hold on to these Peter Pan neurons to keep the brains emotional responses flexible and adaptable into old age.

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In 2019, UCSF drove advancements in care delivery, scientific discovery, education, public service, and more. See the highlights

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UCSF's 11 Most Popular Health and Science Stories of 2019 - UCSF News Services

New research targets stem cells that drive aggressive blood cancer – Griffith News

Griffith University researchers played a key role in identifying that particular enzymes are critical for regulating leukemic stem cells.

In collaborative research published in Nature, the team found a way to target acute myeloid leukaemia (AML) at its source a discovery that could yield a more effective treatment for this aggressive and often incurable blood cancer.

Led by the Peter MacCallum Cancer Centre in Melbourne, Professor Vicky Averys team from the Griffith Research Institute for Drug Discovery contributed to the publication by developing essential cellular assays.

These wereutilisedtoidentify and evaluatehighly selective small molecule inhibitors that discriminatedbetween the major families of histone acetyltransferases(HAT),whichplay pivotal rolesin leukaemiastem cellregulation.

Thisresearch providesvalidation ofHBO1as a target forcancerdrug discovery, Professor Avery said.

Ithas the potential to significantly impact future therapeutic interventions for cancers in urgent need of novel therapeutic strategies.

Prof Mark Dawson and Dr Laura MacPherson led the international research team, in collaboration with researchers in Europe and Australia including at the Walter and Eliza Hall Institute of Medical Research (WEHI), Monash Institute for Pharmaceutical Sciences (MIPS) and Cancer Therapeutics CRC.

They identified a new druggable target in AML stem cells, which are the roots that sustain this type of cancer. Although these stem cells are rare, they are likely to be the main cause for resistance to current anti-cancer therapies.

Our current treatments for AML are good at eliminating the majority of cancer cells but they can leave these rare leukemic stem cells behind, resulting in the cancer coming back after treatment, Prof Dawson said.

There is a critical need for new AML treatments that eradicate these stem cells, and with this discovery weve taken a major step towards such a treatment.

In the paper the scientists described how the protein HBO1 was essential for the survival of leukemic stem cells. When HBO1 is lost, these cells are no longer ableto drive cancer growth in laboratory models of human and mouse AML.

We found that HBO1 loss caused these difficult-to-treat leukemic stem cells to cease dividing, transition to less malignant forms and, in some cases, undergo cell death, study lead author Dr MacPherson said.

The scientists then undertook a series of experiments to discover the part of the HBO1 protein that was critical for its function in stem cells. In collaboration with medicinal chemists in Melbourne, the team developed a small molecule the first building block of a drug that could suppress the activity of HBO1 in AML cells.

When we treated a range of human and mouse AML cells with a drug that inhibits HBO1 in the laboratory, we discovered that this compound potently induced anti-cancer effects, Dr MacPherson said.

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New research targets stem cells that drive aggressive blood cancer - Griffith News

Platelet Rich Plasma and Stem Cell Alopecia Treatment Market is Projected to Reach US$XX by the end of 2018 – 2026 – Markets Gazette 24

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competitive landscape of the industrial workwear market, thereby positioning all the major players according to their geographic presence and recent key developments. The comprehensive industrial workwear market estimates are the result of our in-depth secondary research, primary interviews, and in-house expert panel reviews. These market estimates have been analyzed by taking into account the impact of different political, social, economic, technological, and legal factors along with the current market dynamics affecting the growth of the industrial workwear market. Market share analysis has been included under the competitive landscape to understand the top players contribution to the market. Each company is studied on the basis of basic information, financial highlights, revenue highlights of regional contribution and segment contribution, and product portfolio. Additionally, the company strategy and recent developments if any are also incorporated under each company profile section.

Some of the key players in the industrial workwear market include 3M, VF Corporation, Ansell Ltd., and Honeywell International Ltd., E. I. du Pont de Nemours and Company, Williamson-Dickie Manufacturing Co., Hultafors Group, Lakeland Inc., Aramark, and Fristads Kansas Group. The key players operating in the industrial workwear market adopt numerous strategies to sustain in the market. Product development and acquisition and partnership are some of the main strategies adopted by key players to gain a competitive edge.

The industrial workwear market is segmented as follows:

Industrial Workwear Market

By Product Type

By End-use Industry

By Fit Type

By Distribution Channel

By Geography

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Platelet Rich Plasma and Stem Cell Alopecia Treatment Market is Projected to Reach US$XX by the end of 2018 - 2026 - Markets Gazette 24

Does Mayo do anything with Stem cell treatments for copd …

Hi all,One of Mayo Clinic's focus area of Regenerative Medicine is in Lung Regeneration. Learn more here: http://www.mayo.edu/research/centers-programs/center-regenerative-medicine/focus-areas/lung-regeneration

It can be really difficult to tell which stem cell therapies and regenerative medicine practices are effective and which institutions are offering evidence-based proven therapies. In fact, recently the Food and Drug Administration (FDA) released a stern warning against unproven stem cell therapies. The FDA issued these two press statements: https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm573427.htm and https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm573431.htm.

To help people learn more about the proven therapies and the promise of developing therapies, Mayo Clinic offers a free telephone consult service. When you call the consult service, they will tell you about the availability of approved stem cell therapy at Mayo Clinic and elsewhere, and for what conditions. They can also tell you about research studies that are actively recruiting participants. Furthermore, you can add your name to a database to be notified when additional studies and information become available. You can learn more about the Consult Service here http://www.mayo.edu/research/centers-programs/center-regenerative-medicine/patient-care/clinical-services/regenerative-medicine-consult-service.Or call 1-844-276-2003 to speak with one of our experts.

@oldman1946, I agree with @kpeace. It's important to do your research to ensure that the promised therapy is evidence-based and not just a money grab.

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Does Mayo do anything with Stem cell treatments for copd ...

Stem Cell Therapy Charlotte NC | Stem Cell Therapy for Pain

Most patients (80%) have a positive response. Like everything else in medicine, Stem Cells or Growth Factors may not help everyone. Response to regenerative therapy depends on the underlying health of the patient, their baseline level of activity, their weight, and the severity of the underlying condition.

Patients with very mild arthritis who are active usually respond better than someone with so-called bone on bone arthritis, but in our experience, even patients with advanced degrees of arthritis can benefit from regenerative therapy. In many cases, regenerative therapy has been able to delay joint replacement surgery. Our hope is that if people receive this treatment early on in the course of their arthritis, they may even be able to prevent joint replacement entirely.

We have seen many patients who were told by other clinics that they were bone on bone in an effort to scare them into having surgery performed right away when in fact their arthritis was not that severe and they responded very well to treatment.

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Stem Cell Therapy Charlotte NC | Stem Cell Therapy for Pain

Stem Cell The Latest Research On Stem Cell Treatments …

December 22, 2016 Knee Pain

There are several clinics throughout the US working with stem cell therapy, and developments in the field are continually growing. Although we primarily use stem cells for treating degenerative conditions and diseases, there are also other studies that utilize similar biologics to further research in the field. Here are just a few of the latest scientific developments this year:

June 2016. Understanding Conversion of Stem Cells into Specific Organ Cells. Stem cells are the basic, universal cell material that allow all cells to develop within our body. We have not been able to readily understand the conversion of the cell into a given organ cell, but that is changing. Researchers have developed a nanoprobe capable of penetrating a stem cell wall and accessing its microRNA to assess how the stem cells divisions become a specific body part cell. They have tracked the stem cell division process for five days. By understanding the mechanics of stem cell RNA in the division process, we are potentially closer to guiding that process for specific organ cells desired for therapies. Read more by visiting the article here.

July 2016. CRISPR and Editing Human Pluripotent Stem Cells. Alternative stem cell sources can be derived from a variety of body tissues. They, just like fetal stem cells, have the capacity to develop into virtually organ cells from any part of the body. The problem has been, what can be done when there is a DNA falw in the cell (making its daughter cells flawed in terms of targeting an organ for repair)? The answer? Editing the stem cell. A specific editor, CRISPR/Cas9 can accomplish this purpose and be an aide to stem cell therapy. Read more by visiting the article here.

August 2016. Treatment for Macular Degeneration. Researchers have discovered a clinically efficient way to take the bodys normal cells (not the bodys normally occurring stem cells) and cause them to form specific cells of retinal pigment epithelium. These cells may ultimately be used to replace cells destroyed by the macular degeneration process. This discovery also has implications for other cell therapies for a variety of degenerative conditions. Read more by visiting the articlehere.

October 2016. Consumer Safety Becoming Clinic Focus. Stem cell treatments have become highly innovative and there is a burgeoning industry as new therapies are developed. A variety of research organizations are developing oversight guidelines for safe and effective stem cell therapy innovations that will provide a greater level of safety in the stem cell clinics providing patient therapies across the United States. Read more by visiting the articlehere.

November 2016. Alternatives for Fetal Stem Cells for Parkinsons Disease. This nervous system disease is characterized by loss of dopaminergic neurons in the brain. Symptoms are treated today with medicines, e.g., dopamine, but experiments with amniotic stem cells injected into the brains of Parkinsons patients have shown some success. The source of these stem cells has had ethical and practical implications limiting widespread application of this therapy. Recent alternative stem cell sources appear poised to make this therapy more viable. Read more by visiting the articlehere.

To date, we have come so far with stem cell research. Todays innovations will generate new therapy strategies, and we cannot wait to see what the future holds.

For Stem Cell Therapy Treatment, or to learn more, please call 844-ME-AGAIN (632-4246).

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Stem Cell The Latest Research On Stem Cell Treatments ...

About Stem Cell Therapy – Progencell – Stem Cell Therapies

Congratulations on taking the first step towards learning more about stem cell therapy.

Adult (Non Embryonic) Stem Cells are undifferentiated cells that have the capability to replace dying cells and regenerate damaged tissue. These special cells target areas of injury, disease and destruction where they are capable of regenerating healthy cells and enabling a persons natural healing processes to be accelerated.

As we gain a deeper understanding of their medical function and apply this knowledge, we are realizing their enormous therapeutic potential to help the body heal itself.

Adult stem cells have been used to repair and regenerate acute and chronically damaged tissues in humans and animals to treat a variety of medical conditions.

Adult stem cells are obtained from sources, including bone marrow, cord blood, peripheral blood and others. Because of their properties, each one has particular advantages and disadvantages.

Once the cells are obtained, their quality can be manipulated and assesed and then be infused in the participant. Contamination and damage of natural cell function may increase with too much manipulation. The possibility of rejection and severe post-treatment complications increases substancially if the stem cell donor is different than the patient to be treated, such as a Graft-Versus-Host-Disease.

Stem cell therapy regenerates cells and specific organs that are affected by disease. According to several studies, Stem Cells have the ability to differentiate into other types of cells (cardiac cells, bone/cartilage, liver cells, nerve, etc.). In addition, these Stem Cells have the ability to chemically detect damaged tissue, home those tissues, and directly repair them. This kind of therapy helps to increase the tissues functionality, resulting in considerable improvement of a persons medical condition.

Many people have improved their health conditions by participating in this research protocol (and have received the benefit of keeping their body systems and organs in optimal condition), even where other treatments have failed to work.

Due to the stem cell research hype all over the world, we recommend individuals gather as much information as possible in order to get to the right people and to the correct treatment. There are clinics in which the stem cells are obtained from an unknown donor source and the risks involved could be very high. It is highly recommendable to use only stem cells directly from the same person in order to perform autologous infusions, by doing so, there is no risk of rejection or complications during the extraction and/or infusion process. Read more about stem cell therapy and its potential.

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About Stem Cell Therapy - Progencell - Stem Cell Therapies

Stem Cell Treatment for Dry AMD Moves Closer to Human …

A new treatment for the most severe form of advanced, dry age-related macular degeneration (AMD) has shown promise in an animal study. Researchers hope the treatment, which involves using a patient's own stem cells to replace lost retina cells, will soon be tested in humans.

There are two forms of AMD: dry and wet. About 80% of people who have AMD have the dry form, and there are several kinds of dry AMD. There is currently no way to treat any kind of dry AMD.

In dry AMD, cells called retinal pigment epithelium (RPE) cells die. These cells nurture light-sensing cells in the retina called photoreceptors. Once the cells die, the photoreceptors also eventually die. This cell death results in the most severe form of dry AMDcalled geographic atrophy. Geographic atrophy can lead to blindness.

The new experimental treatment is designed to replace the dying cells with cells that have been created from a patient's blood cells. In the lab, the researchers convert the patient's cells into induced pluripotent stem cells (iPS) cells. These can become any kind of cell in the body.

In this study, researchers programmed human iPS cells to become RPE cells. The lab-made cells were grown in tiny sheets that were one cell thick. The researchers then inserted the cells into the retinas of rats and pigs. Ten weeks after the cells were implanted, the researchers conducted imaging studies that showed the lab-made cells were integrated within the retina.

The transplanted cells functioned properly, the researchers reported in the journal Science Translational Medicine. These healthy new cells could stop any further vision loss from dry AMD and might even be able to return some lost vision.

"Being able to reprogram stem cells to become missing RPE cells is really exciting technology," said Pravin U. Dugel, MD, an ophthalmologist at Retinal Consultants of Arizona in Phoenix.

"It's still very early and there are a lot of challenges ahead, he said. "Just because it works in rats and pigs doesn't necessarily mean it will work in humans. But we don't have any treatment for dry AMD, so this is something to watch out for."

Dr. Dugel noted that a key concern with any stem cell therapy is that changing the nuclear structure of the cell has the potential to cause cells to multiply uncontrollably and become cancerous. The researchers said they genetically analyzed the RPE cells derived from stem cells and found no genetic mutations linked to tumor growth. "Although it was not seen in this animal study, it always remains a possibility, and that has to be overcome," Dr. Dugel said.

The researchers have started to plan a Phase I clinical trial to test the safety of the treatment in humans. The U.S. Food and Drug Administration must still approve the trial before it can begin.

"If the clinical trial moves forward, it would be the first ever to test a stem cell-based therapy derived from induced pluripotent stem cells for treating a disease," lead researcher Kapil Bharti, PhD, of the National Eye Institute said in a news release.

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Stem Cell Treatment for Dry AMD Moves Closer to Human ...