Induced Pluripotent Stem Cells Global Market Report 2023-2028 – Key Market Drivers Include Use of iPSCs in … – PR Newswire

DUBLIN, Jan. 10, 2024 /PRNewswire/ --The"Induced Pluripotent Stem Cells: Global Markets 2023-2028" report has been added toResearchAndMarkets.com's offering.

This study focuses on the market side of iPSCs rather than the technical side. Different market segments for this emerging market are covered. For instance, product function-based market segments include molecular and cellular engineering, cellular reprogramming, cell culture, cell differentiation, and cell analysis. Application-based market segments include drug development and toxicity testing, academic research, and regenerative medicine. iPSC-derived cell type-based market segments include hepatocytes, neurons, cardiomyocytes, endothelial cells, and other cell types.

Other cell types are comprised of astrocytes, fibroblasts, and hematopoietic and progenitor cells, among other substances. Geographical-based market segments include the U.S., Asia-Pacific, Europe, and the Rest of the World. The research and market trends are also analyzed by studying the funding, patent publications, and research publications in the field.

This report focuses on the market size and segmentation of iPSC products, including iPSC research and clinical products. The market for iPSC-related contract services is also discussed. iPSC research products are defined as all research tools, including iPSCs and various differentiated cells derived from iPSCs, various related assays and kits, culture media and medium components (e.g., serum, growth factors, inhibitors), antibodies, enzymes, and products that can be applied for the specific purpose of executing iPSC research. For this report, iPSC products do not cover stem cell research and clinical products that are broadly applicable to any stem cell type.

This report discusses key manufacturers, technologies, and factors influencing market demand, including the driving forces and limiting factors of the iPSC market's growth. Based on these facts and analysis, the market trends and sales for research and clinical applications are forecast through 2028.

One particular focus on the application of iPSCs was given to drug discovery and development, which includes pharmaco-toxicity screening, lead generation, target identification, and other preclinical studies; body-on-a-chip; and 3D disease modeling. Suppliers and manufacturers of iPSC-related products are discussed and analyzed based on their market shares, product types, and geography. An in-depth patent analysis and research funding analysis are also included to assess the overall direction of the iPSC market.

Detailed technologies such as those for generating iPSCs, differentiating iPSCs and controlling the differentiation, and large-scale manufacturing of iPSCs and their derivative cells under Good Manufacturing Practice (GMP) compliance or xeno-free conditions are excluded from the study. They are beyond the scope of this report.

The induced pluripotent stem cell market has been analyzed for four main geographic regions: The U.S., Europe, Asia-Pacific, and the Rest of the World (RoW). The report will provide details with respect to induced pluripotent stem cells.

The Report Includes

Companies Profiled

Key Topics Covered:

Chapter 1 Introduction

Chapter 2 Summary and Highlights

Chapter 3 Market Overview

Chapter 4 Market Dynamics

Chapter 5 Induced Pluripotent Stem Cell Applications

Chapter 6 Induced Pluripotent Stem Cell Market Segmentation and Forecast

Chapter 7 Induced Pluripotent Stem Cells Research Application Market

Chapter 8 Induced Pluripotent Stem Cell Contract Service Market

Chapter 9 Clinical Application Market Trend Analysis

Chapter 10 Competitive Landscape

For more information about this report visit https://www.researchandmarkets.com/r/i3vsaw

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Induced Pluripotent Stem Cells Global Market Report 2023-2028 - Key Market Drivers Include Use of iPSCs in ... - PR Newswire

Global Cell Line Development Industry on Track for a US$10.6 Billion Boom by 2033, Fuelled by 7.7% CAGR | FMI … – Market Research Blog

In a groundbreaking revelation, the Global Cell Line Development Industry is poised for an extraordinary surge, with sales projected to reach an impressive US$10.6 billion by 2033, propelled by a robust Compound Annual Growth Rate (CAGR) of 7.7% from 2023. These findings, based on a comprehensive analysis by Future Market Insights (FMI), reveal a significant leap from the estimated US$4.7 billion valuation in 2022.

The driving force behind this unprecedented growth is the escalating adoption of bio-therapeutics for the treatment of chronic diseases such as arthritis, diabetes, and cancer. As the demand for innovative therapeutic solutions continues to rise, the Global Cell Line Development Industry is witnessing an increased need for automated cell line development and specialized cell line development services.

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The rapid increase in the prevalence of cancer and neurology disorders and the lack of efficient treatment solutions for these diseases have created the need for more advanced and efficient treatment pathways. Companies and government organizations are investing in research and development activities and are also focusing more on cell line development in search of new cellular pathways to develop novel drugs. The increased spending on biosimilar R&D from exiting biopharmaceutical companies would provide a boost to the Global Cell Line Development Industry.

In recent times contract research organizations have focused on cell line development and cell line research activities. According to the National Institutes of Health (NIH), the estimated total federal spending on all types of stem cell line research for 2017 is US$ 1.58 Bn. In developing countries like India, the government is supporting cell line development through national funding agencies like the Department of Biotechnology (DBT), the Indian Council of Medical Research (ICMR), and the Department of Science and Technology (DST).

Regenerative medicines are the next-generation treatment solution and Cell Line Development or Cell Culture is a vital part of regenerative medicine. Increasing demand for regenerative medicines in cancer treatment would positively impact the growth of the Global Cell Line Development Industry over the forecast period.

The biopharmaceutical companies operating in the development of novel drug lines are expected to hold promising revenue opportunities in the Global Cell Line Development Industry.

Future Market Insights (FMI) has segmented the Global Cell Line Development Industry based on product type, cell line source type, end user, type of cell line, and region.

Product type segment in the Global Cell Line Development Industry is segmented into media and reagents, equipment, and accessories. Reagents and Media are required from incubation to preservation of cell lines. These products are expensive and have repetitive use in cell culture or bio-production. The reagent and media segment in the cell line development market is expected to witness noteworthy growth in terms of revenue owing to a rapid increase in demand for cell culture and cell-based assays.

Global Cell Line Development Industry by cell line source is categorized into mammalian cells and non-mammalian cells. Mammalian cell line development is anticipated to witness significant growth in the overall Global Cell Line Development Industry. This growth of the mammalian cells segment in the cell line development market is driven by increased production of biologics drugs that require mammalian cells. Increasing antibody production is the major driving factor behind the growth of the mammalian cell lines segment in the Global Cell Line Development Industry.

Mammalian cell lines are used to create therapeutic proteins through genetic building and antibodies through viral infection. For example, Gauchers disease, is a genetic disorder characterized by a lack of -glucocerebrosidase enzyme and can be treated by Cerezyme which is a recombinant enzyme produced in mammalian cell lines. Mammalian cell lines are also useful in the production of antibodies and other therapeutic agents such as specific binding proteins that can neutralize disease-causing agents in the body. For example Under the cell line type segment in the Global Cell Line Development Industry, recombinant cell line development is the most demanding type of cell line due to its large application in biologics production, protein interaction, gene activation, toxicity testing, and drug screening.

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Growing application recombinant cell line development in drug toxicity testing is expected to boost the growth of overall cell line development during the forecast period

North American and European cell line development markets will dominate owing to increasing government funding in cell line development research and rising spending on biosimilar developments. Asia Pacific cell line development market is expected to grow at a high growth rate due to the increased number of research organizations engaged in novel biologics and biosimilars fastest revenue growth in the overall cell line development market.

The Asia Pacific region in the Cell line development market is anticipated to witness increasing demand for biopharmaceuticals and regenerative medicines are expected to boost the growth of the cell line development market.

FMIs report tracks some of the key companies operating in the Global Cell Line Development Industry, such as Selexis SA, GE Healthcare, Corning Incorporated, Thermo Fischer Scientific, Inc., American Type Culture Collection (ATCC), Lonza (Sartorius Stedim Biotech S.A.), Danaher Corporation, Merck KGaA, WuXi Biologics.

Key Segments:

By Source Type:

By End User:

By Cell Lines:

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Author

Sabyasachi Ghosh(Associate Vice President at Future Market Insights, Inc.) holds over 12 years of experience in the Healthcare, Medical Devices, and Pharmaceutical industries. His curious and analytical nature helped him shape his career as a researcher.

Identifying key challenges clients face and devising robust, hypothesis-based solutions to empower them with strategic decision-making capabilities come naturally to him. His primary expertise lies in areas such as Market Entry and Expansion Strategy, Feasibility Studies, Competitive Intelligence, and Strategic Transformation.

Holding a degree in Microbiology, Sabyasachi has authored numerous publications and has been cited in journals, including The Journal of mHealth, ITN Online, and Spinal Surgery News.

About Future Market Insights (FMI)

Future Market Insights, Inc. (ESOMAR certified, recipient of the Stevie Award, and a member of the Greater New York Chamber of Commerce) offers profound insights into the driving factors that are boosting demand in the market. FMI is the leading global provider of market intelligence, advisory services, consulting, and events for the Packaging, Food and Beverage, Consumer Technology, Healthcare, Industrial, and Chemicals markets. With a team of over 5,000 analysts worldwide, FMI provides global, regional, and local expertise on diverse domains and industry trends across more than 110 countries.

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Global Cell Line Development Industry on Track for a US$10.6 Billion Boom by 2033, Fuelled by 7.7% CAGR | FMI ... - Market Research Blog

CellVoyant secures 7.6 million seed funding to develop stem cell therapies with AI – BioPharma-Reporter.com

Led by Octopus Ventures, with participation from Horizons Ventures, Verve Ventures, and Air Street Capital, this funding marks the first stage in commercialising CellVoyant's AI and imaging platforms.

The company aims to enable the cost-effective and rapid development of novel cell therapies. The proceeds from this funding round will be used to increase headcount, expand laboratory and experimental infrastructure, and support R&D.

Rafael E. Carazo Salas, CEO and founder of CellVoyant, said: Cell therapies have the potential to revolutionise the way we treat diseases that affect millions of people every year. By combining the latest advances in AI and live cell imaging, we can help bring these transformative treatments to the market quickly, reliably, and cost-effectively. Todays milestone validates the potential of our approach and will help us to accelerate our R&D capabilities.

Stem cells unlock a range of treatment possibilities that have not previously been available to patients. Current treatment options act on the bodys existing cells, while stem cells can develop into many different cell types in the body - regenerating damaged tissues and organs or replacing dysfunctional and dead cells.

There are already promising potential applications in chronic diseases, such as cancer, and metabolic diseases like diabetes and age-related macular degeneration. In future, stem cells could be used to alleviate currently untreatable conditions like dementia, fertility, and spinal cord injury.

Stem cell biology is complex and unpredictable, and producing pure, viable populations of stem cell derivatives at clinical scale can be slow and challenging.

In fact, 84% of cell therapy assets fail within two years of development, and 47% of cell therapy assets still fail after the five-year point in development.

CellVoyants platform combines advanced AI with live cell imaging to address these concerns.

Its technology can extract spatial and temporal information in real-time from hundreds of millions of cells within complex cell mixtures, helping scientists understand their composition and forecast how they will evolve.

This allows them to forecast stem cell behaviour with unprecedented precision and find optimal pathways for differentiating cells into specific cell types, such as nerve, cardiac or blood, facilitating more effective development of cell therapies.

According to the company, its technology can improve target cell yields, reduce time, and can offer potential savings of $10 100 million per therapy.

Uzma Choudry, Lead Biotech Investor at Octopus Ventures, added: University spin-outs like CellVoyant are at the heart of the UKs thriving biotech ecosystem. CellVoyant sets a new standard in precision and reliability for predicting and controlling stem cell behaviour, which will make cell therapies more accessible to those who need them. We are thrilled to invest into a company that is transforming how patients can benefit from life-changing treatments.

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CellVoyant secures 7.6 million seed funding to develop stem cell therapies with AI - BioPharma-Reporter.com

Researchers genetically modify stem cells to evade immunological rejection – University of Arizona

One of the biggest barriers to regenerative medicine is immunological rejection by the recipient, a problem researchers at the University of Arizona Health Sciences are one step closer to solving after genetically modifying pluripotent stem cells to evade immune recognition. The study Engineering Human Pluripotent Stem Cell Lines to Evade Xenogeneic Transplantation Barriers waspublished in Stem Cell Reports today.

Pluripotent stem cells can turn into any type of cell in the body. The findings offer a viable path forward for pluripotent stem cell-based therapies to restore tissues that are lost in diseases such as Type 1 diabetes or macular degeneration.

There has been a lot of excitement for decades around the field of pluripotent stem cells and regenerative medicine, said principal investigator Deepta Bhattacharya, PhD, a professor in the UArizona College of Medicine Tucsons Department of Immunobiology. What we have learned from the experiences of organ transplantation is that you have to have matched donors, but the person receiving the transplant often still requires lifelong immune suppression, and that means there is increased susceptibility to infections and cancer. Weve been trying to figure out what it is that you need to do to those stem cells to keep them from getting rejected, and it looks like we have a possible solution.

To test their hypothesis, Bhattacharya and the research team used CRISPR-Cas9 technology, genetic scissors that allow scientists to make precise mutations within the genome at extremely specific locations.

Using human pluripotent stem cells, the team located the specific genes they believed were involved in immune rejection and removed them. Prior research into pluripotent stem cells and immune rejection looked at different parts of the immune system in isolation. Bhattacharya and his colleagues from The New York Stem Cell Foundation Research Institute, St. Jude Childrens Research Hospital and the Washington University School of Medicine opted to test their genetically modified stem cells in a complete and functional immune system.

The immune system is really complicated and there are all sorts of ways it can recognize and reject things, said Bhattacharya, a member of the UArizona Cancer Center and the BIO5 Institute who also serves on the UArizona Health Sciences Center for Advanced Molecular and Immunological Therapies advisory council.

Transplantation across species, across the xenogeneic barrier, is difficult and is a very high bar for transplantation. We decided if we could overcome that barrier, then we could start to have confidence that we can overcome what should be a simpler human-to-human barrier, and so thats basically what we did.

The research team tested the modified stem cells by placing them into mice with normal, fully functioning immune systems. The results were promising the genetically engineered pluripotent stem cells were integrated and persisted without being rejected.

That has been the holy grail for a while. You might actually have a chance of being able to perform pluripotent stem cell-based transplants without immune suppressing the person who is receiving them. That would be an important advance, both clinically and from the simple standpoint of scale, Bhattacharya said. You wouldnt have to make individualized therapies for every single person you can start with one pluripotent stem cell type, turn it into the cell type you want and then give it to almost anyone.

The next steps, Bhattacharya said, include testing the genetically modified pluripotent stem cells in specific disease models. He is already working with collaborators at The New York Stem Cell Foundation and the Juvenile Diabetes Research Foundation to test the technology in animal models for Type 1 diabetes.

We needed to overcome the immune system first. The next steps are how do we use these cells? Bhattacharya said. We set the bar pretty high for our study and the fact that we were successful gives us some confidence that this can really work.

Bhattacharya also is the co-founder of startup Clade Therapeutics in Boston, which licensed the technology through Tech Launch Arizona, the University of Arizonas commercialization arm. Clade Therapeutics is establishing a robust cellular platform using stem cell-derived immune cells for the treatment of cancer and autoimmune diseases. The company said it hopes to begin clinical trials by the end of the year.

Co-authors on the paper include: Hannah Pizzato, PhD, research specialist in the College of Medicine Tucsons Department of Immunobiology; Paula Alonso-Guallart, DVM, PhD, James Woods and Frederick J. Monsma Jr., PhD, of The New York Stem Cell Foundation Research Institute; Jon P. Connelly, PhD, and Shondra M. Pruett-Miller, PhD, of the St. Jude Childrens Research Hospital; and Todd A. Fehniger, MD, PhD, and John P. Atkinson, MD, of the Washington University School of Medicine.

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Researchers genetically modify stem cells to evade immunological rejection - University of Arizona

Cell Therapy Technologies Market Projected to Reach Valuation of USD 47.3 Billion at 24.7% CAGR from 2024-2033 … – GlobeNewswire

New York, Jan. 16, 2024 (GLOBE NEWSWIRE) -- In 2023Cell therapy technologiesmarket were valued at USD 5.5 billion in 2023 with significant growth and are projected to reach USD 47.3 billion by 2033 with an outstanding CAGR of 24.7%.

The surge in demand for advanced diagnostic tools and therapeutic interventions is pushing the cell therapy technology market forward. Cell therapy, a main element in treating regenerative medicines, has become extensively popular, particularly in regenerative medicine. Combined with other equipment like Platelet-Rich plasma (PRP), cell therapy improves its power and effectiveness, proposing extra benefits to patients.

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Cell therapy comprises launching innovative, healthy cells into a patient's body, playing a vital role in handling certain cancers and neurological diseases such as Parkinson's, amyotrophic lateral sclerosis (ALS), and diabetes. With over 1 million individuals worldwide suffering from Parkinson's disease, a number projected to reach 1.2 million by 2030, cell therapy emerges as a promising solution. Likewise, ALS is predominant, mostly in Western Europe, where it has a prevalence rate of 9.62 per 1,000,000 populations.

The benefits of cell therapy technologies comprise pain reduction, augmented functionality, fast-tracked recovery, aid in complex injuries, and a reduced risk of nerve damage and communicable diseases. As these therapies display innovative diagnostic and treatment methods, the market is poised for rapid expansion to meet the cumulative requirement for transformative medical solutions during the forecasted period.

Key Takeaways

Driving Factors

Introduction of Innovative Products

These innovative products, crafted to meet the requirements of different patients, have been instrumental in the advancement of cell therapies. This trend of continual product innovation is essential for keeping pace with the evolving demands of healthcare, ensuring the market's resilience and adaptability. The focus on innovation drives market growth by providing more effective, efficient, and tailored treatment options, thereby enhancing patient outcomes and expanding the potential applications of cell therapies. The market is composed of unrelenting growth, reinforced by a pipeline of advanced transformative cell therapy technologies.

Enhanced Demographic and Environmental Dynamics

Population growth escalates the demand for innovative healthcare solutions, including cell therapies for diverse medical conditions. Climate change, influencing disease patterns and health vulnerabilities, further propels the need for advanced treatments. These key factors collectively drive the development and adoption of cell therapy technologies, as they offer targeted and efficient treatment options for an array of health issues emerging in this changing global landscape.

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Restraining Factors

Cost and Reimbursement Issues

Cell therapy treatments are typically associated with high costs, both in terms of production and administration. The problem of reimbursement and costs is crucial to the development of the cell-based therapy business. Furthermore, the lack of clear reimbursement pathways adds to the complexity as insurers grapple with how to classify and cover these novel treatments. This makes them financially out of reach for many patients and healthcare systems. These financial hurdles not only limit patient access but also deter investment and innovation in the field, as developers and benefactors face vagueness about the return on their significant funds in these advanced therapies.

Growth Opportunities

Increased Interest in customized medicines

Personalized medicine's approach of tailoring treatments to individual patients aligns perfectly with the capabilities of cell therapies. These therapies' adaptability to patient-specific needs positions them at the forefront of innovative treatments for a variety of medical conditions. This illustrates the growing significance of technology in the realm of personalized healthcare in the upcoming era of cell therapy. As healthcare continues to evolve towards more personalized strategies, the demand for cell therapy technologies is expected to rise, bolstered by their potential to provide targeted, patient-specific treatments.

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Regional Analysis

North America rules the cell therapy technologies market, holding 55.60% due to robust research infrastructure, substantial biotech investments, and favorable policies. The U.S. leads with ground-breaking biotech firms and supportive government initiatives. Europe, compelled by research and regulatory support, sees contributions from Germany, the UK, and France. In Asia-Pacific, prompt market growth results from augmented healthcare investments and biomedical research, particularly in Japan and South Korea. The region's large population and rising chronic diseases present substantial opportunities for expanding cell therapy technologies.

Segment Analysis

By therapy type, Autologous therapies rule the market segment due to their substantial role in treatments utilizing cells. This method is widely used in various treatments, including certain types of cancer therapies, where patients' cells are engineered to fight cancer cells more effectively. Through the use of donors' cells, allogeneic therapies can play a significant role in treatments utilizing cells. The most significant benefit of autologous treatment is that there is less possibility that the immune system will reject it and related complications since the cells are derived from patients themselves. These therapies have the advantage of being available off-the-shelf, making them more accessible and sometimes more cost-effective.

By cell type, stem cells dominate the market segment due to their extensive use in hematopoietic stem cell transplantation for blood and bone marrow disorders. Stem cells ability to differentiate into various cell types makes them incredibly valuable in regenerative medicine and the treatment of various diseases. Adipose-derived stem cells are being explored for their potential in regenerative therapies due to their abundance and ease of extraction. Non-stem cell therapies, while not as adaptable as stem cells, are important in precise therapeutic applications, predominantly in certain types of cancer treatments where immune cells are contrived to target cancer cells.

By cell therapy therapeutic area type, oncology leads the market segment due to the effectiveness of cell therapy in treating various types of cancers, particularly through approaches like CAR-T cell therapies, which have transformed cancer treatment. These therapies have shown remarkable results in certain types of blood cancer, leading to significant investment and research in expanding their application to other cancer types. In dermatology, cell therapies offer advanced treatment options for skin regeneration and healing. Other therapeutic areas like cardiovascular disease (CVD), musculoskeletal disorders, dermatology, and others are also significant. Cell therapies in CVD aim to regenerate damaged heart tissue, while in musculoskeletal disorders, they are used for tissue repair and pain management.

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Segments Covered in this Report

By Therapy Type

By Cell Type

By Cell Therapy Therapeutic Area

By Geography

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Competitive Landscape Analysis

In the dynamic field of cell therapy technologies, industry front-runners such as Thermo Fisher Scientific, Danaher Corporation, Becton, Dickinson & Company, Merck KGaA, Lonza Group, Sartorius AG, FUJIFILM Irvine Scientific, and Avantor, Inc. play pivotal roles. Their inclusive product ranges and tactical focuses on innovation, accuracy, and amalgamation contribute significantly to advancing cell therapy research, manufacturing, and efficiency.

Key Market Players

Recent Developments

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Cell Therapy Technologies Market Projected to Reach Valuation of USD 47.3 Billion at 24.7% CAGR from 2024-2033 ... - GlobeNewswire

Life Science Research Heads to the ISS on Axiom Mission 3 – ISS National Lab

KENNEDY SPACE CENTER (FL), January 10, 2024 More than two dozen investigations sponsored by the International Space Station (ISS) National Laboratory, many of which focus on the life sciences, will fly on Axiom Spaces third private astronaut mission to the orbiting laboratory. Axiom Mission 3 (Ax-3) aims to help expand a new era of privatized utilization of the space station that will bring value to humanity while enabling the development of a robust and sustainable market in low Earth orbit (LEO) by advancing research in microgravity.

Four astronauts are slated to launch on a SpaceX Falcon 9 rocket and Dragon spacecraft to the space station no earlier than Wednesday, January 17, at 5:11 p.m. EST from NASAs Kennedy Space Center in Florida. During a planned two-week mission, Axiom Spaces chief astronaut and former NASA astronaut Michael Lpez-Alegra (commander), Walter Villadei of Italy (pilot), Alper Gezeravc of Trkiye (mission specialist), and European Space Agency (ESA) project astronaut Marcus Wandt of Sweden (mission specialist) will conduct more than 30 experiments.

Building on years of foundational research performed in microgravity, a number of these investigations aim to utilize the unique LEO environment to better understand an array of biological processes, including how spaceflight affects the human body, the mechanisms behind certain diseases, and how stem cell research can help lead to the development of novel therapeutics.

Below are some highlights of the investigations launching on the Ax-3 mission:

Through these private astronaut missions, Axiom Space and the ISS National Lab partner to expand access to the unique microgravity environment for the benefit of humanity. Ax-3 represents the first all-European commercial mission to the space station, further expanding spaceflight opportunities to more countries, companies, and people. In addition to the projects highlighted above, Ax-3 includes a strong focus on the scientific portfolios of the European nations represented on this mission, seeking to enhance scientific knowledge gained for humanity.

Read more about these investigations and others launching on this mission in Axiom Spaces Research Overview and on the ISS National Lab Ax-3 launch page.

Download the high-resolution image for this release: Axiom-2 Launch

Media Contact: Patrick ONeill 904-806-0035 PONeill@ISSNationalLab.org

# # #

About the International Space Station (ISS) National Laboratory: The International Space Station (ISS) is a one-of-a-kind laboratory that enables research and technology development not possible on Earth. As a public service enterprise, the ISS National Laboratory allows researchers to leverage this multiuser facility to improve quality of life on Earth, mature space-based business models, advance science literacy in the future workforce, and expand a sustainable and scalable market in low Earth orbit. Through this orbiting national laboratory, research resources on the ISS are available to support non-NASA science, technology, and education initiatives from U.S. government agencies, academic institutions, and the private sector. The Center for the Advancement of Science in Space (CASIS) manages the ISS National Lab, under Cooperative Agreement with NASA, facilitating access to its permanent microgravity research environment, a powerful vantage point in low Earth orbit, and the extreme and varied conditions of space. To learn more about the ISS National Lab, visit our website.

As a 501(c)(3) nonprofit organization, CASIS accepts corporate and individual donations to help advance science in space for the benefit of humanity. For more information, visit our donations page.

About Axiom Space: Axiom Space is building for beyond, guided by the vision of a thriving home in space that benefits every human, everywhere. The leading provider of human spaceflight services and developer of human-rated space infrastructure, Axiom Space operates end-to-end missions to the International Space Station today while developing its successor, Axiom Station the worlds first commercial space station in low-Earth orbit, which will sustain human growth off the planet and bring untold benefits back home. For more information visit Axiom Spaces website.

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Life Science Research Heads to the ISS on Axiom Mission 3 - ISS National Lab

Sarah Irvine’s Battle with MS: The Hope of Stem Cell Treatment – BNN Breaking

Sarah Irvines Battle with MS: The Hope of Stem Cell Treatment

On a quiet street in a bustling city, Sarah Irvine lives a life that is far from ordinary. Diagnosed with a progressive form of multiple sclerosis (MS) in 2019, she faces a daily battle against her own body. In the midst of the turmoil, Sarah, like a beacon of resilience, is aspiring to undergo stem cell treatment in London, a decision that could potentially change the course of her life.

Multiple sclerosis is a debilitating condition where the immune system, in an uncharacteristic act of betrayal, turns against the nerve cells in the brain, spinal cord, and optic nerves. This internal assault can lead to severe impairments in mobility and other neurological functions, trapping individuals in a body that refuses to obey.

For Sarah, this is more than just medical jargon. Its her reality. Every day, she wakes up to a world where simple tasks become Herculean challenges and where the uncertainty of the future looms large. Yet, in the face of adversity, she stands undeterred, ready to fight.

In her quest to combat the impact of this disease, Sarah is setting her sights on a treatment that, while often seen as a last resort, holds the promise of potentially slowing down, or even halting, the progression of her MS symptoms. This treatment involves the transplantation of stem cells, tiny powerhouses of regeneration that may hold the key to resetting the immune system and halting its attack on the nervous system.

Sarahs journey is far from easy. The road to potential treatment is fraught with obstacles, each more daunting than the last. But her determination is unwavering. In her struggle, she becomes a symbol of resilience, a testament to the human spirits indomitable will to survive.

As Sarah navigates her path towards potential recovery, her story serves as a reminder of the ongoing struggle faced by individuals living with MS and the relentless search for effective therapies. In the midst of the battle, however, one thing remains clear: the spirit of the human will, as embodied by Sarah, remains unbroken, undeterred, and unstoppable.

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Sarah Irvine's Battle with MS: The Hope of Stem Cell Treatment - BNN Breaking

A guide to stem cell therapy in Thailand – Thaiger

PHOTO: Stem Cell Therapy at Identity Clinic

You probably have heard about stem cell therapy and its ability to improve your quality of life and feel sceptical about it. While the procedure may sound like something out of science fiction, its actually a promising medical procedure with a wide range of benefits. In fact, it has grown in popularity and shown remarkable effectiveness over the past few years. Thailand has been quick to adapt stem cell therapy and is now leading the charge in Asia.

If youre thinking about getting stem cell therapy in Thailand, you probably have a lot of questions about it. What exactly is it? Is it the appropriate procedure for your condition? Can it really reverse ageing? Where should you head to in Thailand to receive this treatment? To answer some of your questions, we sat down with Dr. Puii and Josh from Identity Clinic Bangkok to get an insight into stem cell therapy in Thailand.

Before we go into details on stem cell therapy in Thailand, lets first talk about the basics.

Stem cell therapy is a newer medical procedure that uses the power of stem cells, which are unspecialized cells that provide new cells for your body as you grow, and replace specialised cells that are damaged or lost. Were born with these cells and they continue to multiply until we reach the age of around 20. After that, though, their numbers and effectiveness start to decline. At around the age of 30 to 35 years old, they take a significant dip in both quality and quantity. This reduction in stem cells is one reason why our bodies start showing signs of ageing.

Stem cells play a crucial role in our health, helping with growth, repair, and even tackling inflammation. Thats why stem cell therapy is a promising medical procedure to treat various medical conditions.

Stem cell therapy provides a wide range of benefits. While it can be used to treat a range of health conditions, stem cell therapy also makes its way into cosmetic treatments and wellness initiatives. Here are some of the main benefits of stem cell therapy that you can get in Identity Clinic Bangkok, Thailand:

Stem cell therapy offers a wide range of benefits for those seeking enhanced well-being.

One of the most popular benefits of stem cell therapy is skin rejuvenation. The therapy facilitates the healing of bruises, cuts, and other skin imperfections. In addition, it can also reduce wrinkles and increase the strength of your dermis the thick layer of living tissue that forms your true skin beneath the epidermis. Stem cell therapy restores the skin deep down to the cellular level, causing your skin to become brighter and tighter. Thus, youll feel refreshed and rejuvenated after each treatment.

In addition to enhancing your immune system, this cutting-edge treatment can also positively impact your sleep quality, which in turn will boost your overall energy levels. Research by DVC Stem reveals that patients undergoing stem cell therapy have reported impressive results, with a notable 75% increase in stamina and a significant 51.40% improvement in energy levels 3 months after treatment.

Stem cell therapy can improve your cognitive function, such as memory and decision-making abilities. Plus, it can make a big difference in how well your nerves send signals to your muscles, which means it can enhance your motor functions.

Youd be amazed to know how much your blood work can benefit from consistent stem cell therapy. Over time, this can also boost the performance of your kidneys and liver, and generally enhance the health of all your organs.

Stem cell therapy in Identity Clinic Bangkok, Thailand can also be used as targeted treatment for specific conditions.

If youve been dealing with knee pain, stem cell therapy may be able to regenerate your knee joints due to arthritis, traumatic ligament injuries, and degenerative conditions.

Stem cell therapy has shown promise in slowing down dementia, such as Alzheimers disease. This is achieved by substituting impaired cells with robust ones, enhancing memory functionality, and regenerating neurons.

Erectile dysfunction, the inability to keep an erection, can be treated with stem cell therapy. With this therapy, the stem cells act as a muscle inside the penis, thereby rejuvenating its tissues and restoring their functionality.

Stem cell therapy is a breakthrough in the treatment of Crohns disease. It has the potential to lessen intestinal inflammation, foster the recovery of the intestinal lining, and enhance your overall life quality.

According to Dr. Puii, another significant benefit of stem cell therapy is helping individuals with pathological conditions like diabetes, hypertension, and heart conditions. Stem cell therapy becomes a continuous treatment option for those seeking to improve and manage their conditions.

Beyond adult treatments, stem cell therapy shows promise in treating chronic diseases in children, such as cerebral palsy, mental disorders, and movement abnormalities. The therapy offers hope for improving conditions that persist into adulthood.

If youve been reading about stem cell therapy, youre probably aware that there are misconceptions surrounding it, causing confusion and fear. One prevalent misconception suggests that stem cell therapy can increase your risk of cancer. There have been no reports of the therapy causing cancer, but to mitigate potential risks, its essential to get this treatment from trusted clinics that use approved stem cells.

Another misconception about stem cells is that they may lead to the growth of extra limbs. Its crucial to clarify that such fantastical claims lack scientific basis. Stem cell therapy, when administered responsibly, adheres to stringent safety standards and does not result in abnormal cell proliferation or limb regeneration.

Its important to remember that while stem cell therapy isnt a universal solution, its not a harmful procedure. Stem cell therapy doesnt reverse ageing or prompt the growth of additional body parts. Instead, its focus is on aiding the bodys natural healing processes and enhancing overall well-being.

There are many medical centres across Thailand offering stem cell therapy, but not all of them are the same. Just like any other healthcare procedure, the most important thing when it comes to stem cell therapy is choosing the right clinic. Be sure to verify that the doctors and staff are well-versed in the procedure and that the clinic is committed to advancing their stem cell therapy technology, This ensures you receive the best possible treatment with a high success rate.

One of the leading clinics offering stem cell therapy in Thailand is Identity Clinic. With top-notch stem cell banks, world-class laboratories, and VIP rooms, the clinic ensures clients receive a royal and unmatched experience. Heres what Identity Clinic offers to their patients:

What sets Identity Clinic apart is its commitment to high-quality stem cells. They use Mesenchymal Stem Cells (MSCs) from the umbilical cord that are carefully screened for health conditions by world-class certified labs and the US FDA. Moreover, these stem cells come with extensive certifications, blood work, and detailed reports. The clinic uses an ID Barcode system to ensure accuracy and traceability. Therefore, clients have full transparency about the stem cells they receive.

Identity Clinic boasts certifications from esteemed global institutions. These include the American Association of Blood Banks (AABB) standards, a recognition highly esteemed by medical organisations worldwide, particularly those in the United States. The clinic also holds the ISO 9001 certification and uses US FDA-approved medical equipment to provide the best and safest procedures for their patients. Furthermore, the clinic has been honoured with the European Society for Quality Research award from Germany, a prestigious recognition given to organisations that demonstrate exceptional quality and ethical practices.

Patients at Identity Clinic enjoy a luxurious and comfortable experience. From the customer service to the interior, the clinic ensures a premium healthcare journey. The staff goes the extra mile to meet all of your needs. Moreover, the treatment rooms are designed to promote both physical comfort and peace of mind as you undergo stem cell therapy.

Identity Clinic takes pride in staying at the forefront of stem cell research and therapy. The dedicated team, led by renowned doctors like Dr. Shin and Dr. Puii, continuously studies and integrates the latest advancements in stem cell treatment.

Stem cell therapy can work wonders in addressing a wide range of medical conditions. And Identity Clinic is dedicated to offering stem cell therapies for all kinds of patients, including those seeking skin rejuvenation. They combine stem cell therapy with state-of-the-art skin treatments like laser procedures and Thermage. This integrated approach not only enhances overall health but also greatly improves skin texture and appearance, adding a youthful glow like never before.

At Identity Clinic, stem cell therapy is not a one-size-fits-all treatment. They offer personalised care plans for various health conditions to make sure that every patient receives positive and sustained effects from their stem cell therapy. To achieve this, they perform a series of preliminary medical evaluations on every new patient prior to beginning their treatment. Among these tests, checking for allergies and carrying out comprehensive assessments for potential underlying medical conditions are essential parts of their preparation protocol.

If youre curious about the potential benefits of stem cell therapy, be sure to contact Identity Clinic for more information. With a focus on quality, certifications, and personalised care plans, the clinic ensures a top-notch experience for every patient.

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A guide to stem cell therapy in Thailand - Thaiger

Clinical applications of stem cell-derived exosomes | Signal Transduction and Targeted Therapy – Nature.com

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Developing in-vivo chimeric lungs with pluripotent stem cells – Drug Target Review

Reverse-blastocyst complementation elucidates the conditions required to form lungs in rat-mouse chimeric models.

Researchers from the Nara Institute of Science and Technology (NAIST) have used the reverse-blastocyst complementation (rBC) method to understand the conditions required to form lungs in rat-mouse chimeric models. They also used the tetraploid-based organ complementation (TOC) method to create a rat-derived lung in their mouse model.

Chronic obstructive pulmonary disease (COPD) is the third leading cause of global deaths. The pathogenesis of COPD is based on the innate and adaptive inflammatory immune response to the inhalation of toxic particles and gases. Although tobacco smoking is the primary cause of this inhalation injury, many other environmental and occupational exposures contribute to the pathology of COPD.1

Lung transplantation is the only viable treatment option, yet finding suitable lung donors is difficult. However, regenerative medicine is advancing the development of lungs from pluripotent stem cells (PSCs) using interspecies animal models. Current expectations for realisation of the promise of PSCs are at the highest they have ever been. However, there are many challenges that need to be addressed in order to bring PSC technology within the grasp of many more patients. Three particular challenges are: tumorigenicity, immunogenicity, and heterogeneity.2

PSCs and embryonic stem cells (ESCs) from one species can be injected into blastocytes, the cluster of diving cells made by a fertilised egg, in a biological technique named blastocyst complementation to create interspecies chimeric animals. This has enabled successful regeneration of the heart, pancreas and kidney in rat-mouse chimeras, but functional lung formation remains to be achieved successfully in vitro due to the complex three-dimensional (3D) structures and multiple cell types needed. This has warranted more research into the viable conditions required to generate PSC-derived organs.

Fibroblast growth factors (FGFs)are polypeptides with various biological activities bothin vivoandin vitro.3 The fibroblast growth factor 10 (Fgf10) and its interaction with the Fgf receptor isoform IIIb (Fgfr2b) in the lungs are essential for lung development. The rBC method in the new study involved injecting mutant ESCs which fail to show lung formation into wild-type (WT) embryos. This allowed for efficient detection of mutant PSCs in the recipient tissue, aiding the determination of the conditions necessary for successful lung formation in the organ-deficient animal.

The team, led by Dr Shunsuke Yuri and Dr Ayako Isotani, discovered that WT ESCs provide uniform contributions across target and non-target organs in the chimeras. This helped to ascertain that a particular number of WT or normal cells are required to overcome the lung development failure in Fgf10-deficient or Fgfr2b-deficient animals.

Having this understanding enabled them to produce rat-derived lungs in the Fgfr2b-deficient mouse embryos with the TOC method, without the requirement of producing a mutant mouse line. Dr Yuri said: Interestingly, we found that the rat epithelial cells conserved intrinsic species-specific timing in the interspecies model, resulting in an underdeveloped lung. Consequently, these lungs remained nonfunctional post-birth.

The studys findings identified the factors required for the successful generation of functional lungs in rat-mouse interspecies chimeras, as well as the issues to overcome. Dr Yuri concluded: We believe that our study makes an important contribution to the literature by presenting a faster and more efficient method of exploring blastocyst complementation.

These novel results can significantly advance the progress toward developingin-vivochimeric lungs for the purpose of transplantation, which could transform the practical application of regenerative medicine.

This study was published in Development.

1 Hogg JC, Timens W. The Pathology of Chronic Obstructive Pulmonary Disease. Annual Review of Pathology: Mechanisms of Disease. 2008 October 27 [2024 January 5]; 4:435-459. Available from: https://doi.org/10.1146/annurev.pathol.4.110807.092145

2 Yamanaka S. Pluripotent Stem Cell-Based Cell Therapy Promise and Challenges. Cell Stem Cell. 2020 October 1 [2024 January 5]; 27(4):523-31. Available from: https://doi.org/10.1016/j.stem.2020.09.014

3 Birnbaum D, Coulier F, Emoto H, Itoh N, Mattei MG, Tagashira S. Structure and Expression of Human Fibroblast Growth Factor-10*. Journal of Biological Chemistry. 1997 September [2024 January 2024]; 272(37):23191-4. Available from: https://doi.org/10.1074/jbc.272.37.23191

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