Stem Cell Clinic

Animal Stem Cell Therapy Market Research Report 2026 Observational Studies With Top Manufacturers – Market Research Sheets

By Stell Cell Research

The Animal Stem Cell Therapy Market is expected to increase more and rapidly, claims the latest report added by SMI.

Animal Stem Cell Therapy Market Outlook from 2019 to 2026. The report has been put together using primary and secondary research methodologies, which offer an accurate and precise understanding of the Animal Stem Cell Therapy market. Analysts have used a top-down and bottom-up approach to evaluate the segments and provide a fair assessment of their impact on the global Animal Stem Cell Therapy market. The report offers an overview of the market, which briefly describes the market condition and the leading segments. It also mentions the top players present in the global Animal Stem Cell Therapy market.

Click to Download Free Global Animal Stem Cell Therapy Market Research Sample PDF Copy Here: https://www.stratagemmarketinsights.com/sample/15082

This comprehensive Animal Stem Cell Therapy research report encompasses a brief on these trends, size, share that can assist the institutions, organizations, corporations, and individuals functioning in the industry to know the Animal Stem Cell Therapy market and strategize for their business growth accordingly. The research report breakdowns the market size, industry share, growth, key segments, CAGR, Application, Type, Application and key drivers.

To comprehend Global Animal Stem Cell Therapy market dynamics in the world mainly, the worldwide Animal Stem Cell Therapy market is analyzed across major global regions. Stratagem Market Insights also provides customized specific regional and country-level reports for the following areas.

North America(United States, Canada & Mexico)Asia-Pacific(Japan, China, India, Australia, etc)Europe(Germany, UK, France, etc)Central & South America(Brazil, Argentina, etc)Middle East & Africa(United Arab Emirates, Saudi Arabia, South Africa, etc)

Geographical Analysis

In order to get a deeper view of Market Size, competitive landscape is provided i.e. Revenue (Million USD) by Players (2014-2019), Revenue Market Share (%) by Players (2014-2019) and further a qualitative analysis is made towards market concentration rate, product/service differences, new entrants and the technological trends in future.

Key highlights from the Study:

1) Any Value Addition Chapters to Provide out of box Assessment?

Market Concentration: Includes C4 Index, HHI, Comparative Market Share Analysis (Y-o-Y), Major Companies, Emerging Players with Heat Map Analysis

Market Entropy: It will provide the randomness of the market which will help you understand the markets aggressiveness; players constantly do expansions, technological advancement, M&A, joint ventures.

Patent Analysis: To overcome competition, players constantly make R&D expenses and to better evaluate uncertain growth scenarios of market players and overall industry a patent analysis chapter introduces which will provide insights like no. of patents issued by players each year.

Peer Analysis: An evaluation of peer to peer analysis by key financial metrics such as EBITDA Margin, Net Profit Margin, Gross Margin, Total Revenue, Segmented Market Share, Assets, etc.

Grab Exclusive Discount on Animal Stem Cell Therapy Market Research @ https://www.stratagemmarketinsights.com/discount/15082

2) How Companies are profiled in the report?

A detailed assessment is done on the list of companies taken into consideration by following certain industry standards to reach the most relevant profile or manufacturers. More emphasis is given on SMEs that are emerging and evolving in the market with their product presence and technological upgraded modes, players that are also part of the study taken from a vast list.

** List of companies mentioned may vary in the final report subject to Name Change / Merger etc.

3) Can we add or profiled a new company or customize the list of companies in the final study?

Yes, we can add or profile a new company as per client needs in the final report. Final confirmation will be provided by the research team depending upon the difficulty of the survey.

** Data availability will be confirmed by research in the case of a privately held company. Few players can be added at no added cost.

4) What details will the competitive landscape will provide?

A value proposition chapter to help you understand what level of business strategies key players are involved along with investment and deal size to gauge market. 2-Page profiles for all listed manufacturers along with 3 years of financial data to evaluate their overall performance in the market along with business overview, product specification, headquarter details, etc.

5) What all regional segmentation covered? Can a specific country of interest be added?

Currently, the research report gives special attention and focus on the following regions:

Asia-Pacific, North America, Europe, South America & Middle East & Africa

** Countries of specific interest can be included.

6) Can the inclusion of additional Segmentation / Market breakdown is possible?

Yes, the inclusion of additional segmentation / Market breakdown is possible subject to data availability and difficulty of survey. However, a detailed requirement needs to be shared with our research before giving final confirmation to the client.

** Depending upon the requirement the deliverable time may vary.

Contact us if any queries before the purchase on this report @ https://www.stratagemmarketinsights.com/quiry/15082

About Us:

Stratagem Market Insights is a management consulting organization providing market intelligence and consulting services worldwide. We bring the expertise of consultants with a cumulative industry experience of more than 70 years. The firm has been providing quantified B2B research and currently offers services to over 350+ customers worldwide. Our reports cover various end-use industries such as Aerospace and Defense, Agriculture, Food and Beverages, Automotive, Chemicals and Materials, Consumer Goods and Retail, Electronics, Energy, Mining, and Utilities, Pharmaceuticals, Manufacturing and Construction, Services, and Healthcare, and ICT.

For More Related Reports: CLICK HERE

This post was originally published on Market Research Sheets

Visit link:
Animal Stem Cell Therapy Market Research Report 2026 Observational Studies With Top Manufacturers - Market Research Sheets

Stem Cell Alopecia Treatment Market Segmentation, Top Companies, Applications, Comprehensive Research Report and Forecast to 2026 – Market Research…

By Stell Cell Research

The recent report added by Verified Market Research gives a detailed account of the drivers and restraints in the Global Stem Cell Alopecia Treatment market. The research report, titled [Global Stem Cell Alopecia Treatment Market Size and Forecast to 2026] presents a comprehensive take on the overall market. Analysts have carefully evaluated the milestones achieved by the global Stem Cell Alopecia Treatment market and the current trends that are likely to shape its future. Primary and secondary research methodologies have been used to put together an exhaustive report on the subject. Analysts have offered unbiased outlook on the global Stem Cell Alopecia Treatment market to guide clients toward a well-informed business decision.

The comprehensive research report has used Porters five forces analysis and SWOT analysis to give the readers a fair idea of the direction the global Stem Cell Alopecia Treatment market is expected to take. The Porters five forces analysis highlights the intensity of the competitive rivalry while the SWOT analysis focuses on explaining strengths, weaknesses, opportunities, and threats present in the global Stem Cell Alopecia Treatment market. The research report gives an in-depth explanation of the trends and consumer behavior pattern that are likely to govern the evolution of the global Stem Cell Alopecia Treatment market.

The following Companies as the Key Players in the Global Stem Cell Alopecia Treatment Market Research Report:

Regions Covered in the Global Stem Cell Alopecia Treatment Market:

Europe (Germany, Russia, UK, Italy, Turkey, France, etc.)

The Middle East and Africa (GCC Countries and Egypt)

North America (United States, Mexico, and Canada)

South America (Brazil etc.)

Asia-Pacific (China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)

The scope of the Report:

The research report on global Stem Cell Alopecia Treatment market includes segmentation on the basis of technology, application, end users, and region. Each segmentation is a chapter, which explains relevant components. The chapters include graphs to explain the year-on-year progress and the segment-specific drivers and restraints. In addition, the report also provides the government outlooks within the regional markets that are impacting the global Stem Cell Alopecia Treatment market.

Lastly, Verified Market Researchs report on Stem Cell Alopecia Treatment market includes a detailed chapter on the company profiles. This chapter studies the key players in the global Stem Cell Alopecia Treatment market. It mentions the key products and services of the companies along with an explanation of the strategic initiatives. An overall analysis of the strategic initiatives of the companies indicates the trends they are likely to follow, their research and development statuses, and their financial outlooks. The report intends to give the readers a comprehensive point of view about the direction the global Stem Cell Alopecia Treatment market is expected to take.

Ask for Discount @https://www.verifiedmarketresearch.com/ask-for-discount/?rid=15102&utm_source=MRS&utm_medium=002

Table of Content

1 Introduction of Stem Cell Alopecia Treatment Market

1.1 Overview of the Market 1.2 Scope of Report 1.3 Assumptions

2 Executive Summary

3 Research Methodology of Verified Market Research

3.1 Data Mining 3.2 Validation 3.3 Primary Interviews 3.4 List of Data Sources

4 Stem Cell Alopecia Treatment Market Outlook

4.1 Overview 4.2 Market Dynamics 4.2.1 Drivers 4.2.2 Restraints 4.2.3 Opportunities 4.3 Porters Five Force Model 4.4 Value Chain Analysis

5 Stem Cell Alopecia Treatment Market, By Deployment Model

5.1 Overview

6 Stem Cell Alopecia Treatment Market, By Solution

6.1 Overview

7 Stem Cell Alopecia Treatment Market, By Vertical

7.1 Overview

8 Stem Cell Alopecia Treatment Market, By Geography

8.1 Overview 8.2 North America 8.2.1 U.S. 8.2.2 Canada 8.2.3 Mexico 8.3 Europe 8.3.1 Germany 8.3.2 U.K. 8.3.3 France 8.3.4 Rest of Europe 8.4 Asia Pacific 8.4.1 China 8.4.2 Japan 8.4.3 India 8.4.4 Rest of Asia Pacific 8.5 Rest of the World 8.5.1 Latin America 8.5.2 Middle East

9 Stem Cell Alopecia Treatment Market Competitive Landscape

9.1 Overview 9.2 Company Market Ranking 9.3 Key Development Strategies

10 Company Profiles

10.1.1 Overview 10.1.2 Financial Performance 10.1.3 Product Outlook 10.1.4 Key Developments

11 Appendix

11.1 Related Research

Request Customization of Report @ https://www.verifiedmarketresearch.com/product/stem-cell-alopecia-treatment-market/?utm_source=MRS&utm_medium=002

We also offer customization on reports based on specific client requirement:

1- Free country level analysis for any 5 countries of your choice.

2- Free Competitive analysis of any market players.

3- Free 40 analyst hours to cover any other data points

About Us:

Verified market research partners with clients to provide insight into strategic and growth analytics; data that help achieve business goals and targets. Our core values include trust, integrity, and authenticity for our clients.

Analysts with high expertise in data gathering and governance utilize industry techniques to collate and examine data at all stages. Our analysts are trained to combine modern data collection techniques, superior research methodology, subject expertise and years of collective experience to produce informative and accurate research reports.

Contact Us:

Mr. Edwyne Fernandes Call: +1 (650) 781 4080 Email: [emailprotected]

This post was originally published on Market Research Sheets

Read the original:
Stem Cell Alopecia Treatment Market Segmentation, Top Companies, Applications, Comprehensive Research Report and Forecast to 2026 - Market Research...

Stem Cell Cartilage Regeneration Market Key players, Geographical Regions and Growth Analysis Outlook Up To 2028 – Sound On Sound Fest

By Stell Cell Research

New York City, NY: December 2019 Published via (Wired Release) If you are involved in the Stem Cell Cartilage Regeneration industry or intend to be, then this examine will offer you a comprehensive outlook. Its vital statistics to preserve your market expertise as much as date.

The global Stem Cell Cartilage Regeneration Market Research Report 2019-2028 accommodates a treasured bunch of data that light up the most critical sectors of the Stem Cell Cartilage Regeneration market. The statistics available in the file delivers all-inclusive facts approximately the Stem Cell Cartilage Regeneration marketplace, which is understandable for an expert. The global Stem Cell Cartilage Regeneration marketplace file provides data concerning all of the aspects associated with the marketplace, which incorporates opinions of the very last product, and the key factors hampering the market growth. It suggests how distinctive gamers are competing within the global Stem Cell Cartilage Regeneration market and discusses strategies theyre using to distinguish themselves from other participants.

To Comprehend The Complete Report Through TOC, Figures, and Tables, Get Free Sample Copy (Download PDF) @https://marketresearch.biz/report/stem-cell-cartilage-regeneration-market/request-sample

The geographical division offers statistics that offer you a concept of the revenue of the groups and sales figures of the Stem Cell Cartilage Regeneration For boom business. Here are highlights of the Geographical Divisions: Asia-Pacific (China, Japan, Korea, India, and Southeast Asia and more), North America (United States, Canada, and Mexico), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria, and South Africa), South America (Brazil, Argentina, Colombia), Europe (Germany, Spain, France, UK, Russia and Italy and more) and ROW (Rest-of-the-World).

Global Stem Cell Cartilage Regeneration Market 2019-2028 Competitive Landscape:-

A variety of leading gamers mention inside the Global Stem Cell Cartilage Regeneration Market research document are focusing on increasing operations in regions, as they exhibit ability business opportunities. The Global Stem Cell Cartilage Regeneration Market record classifies the marketplace dynamics and trends in the international and regional markets considering several aspects together with technology, supplies, capacity, production, profit, and price.

The document reviews the aggressive landscape scenario seen amongst top Stem Cell Cartilage Regeneration Sales players, their employer profile, revenue, sales, business tactics, and forecast Stem Cell Cartilage Regeneration Sales industry situations. According to the research, Stem Cell Cartilage Regeneration Sales marketplace is rather competing and disparate because of worldwide and neighborhood vendors. The global Stem Cell Cartilage Regeneration Sales marketplace record chiefly includes following players- Companies

Segmentation of Global Stem Cell Cartilage Regeneration Market:

Segmentation by stem cell type:

Hematopoietic Stem Cells (HSCs)Pluripotent Stem Cells (iPSC/ESCs)Mesenchymal Stem Cells (MSCs)Segmentation by treatment:

MicrofractureOsteochondral TransplantAutologous Chondrocyte ImplantationStem Cell InjectionsSegmentation by end user:

Hospitals & ClinicsAmbulatory Surgical Centers

Have Any Query? Ask Our Expert @https://marketresearch.biz/report/stem-cell-cartilage-regeneration-market/#inquiry

Global Stem Cell Cartilage Regeneration Market 2019-2028 : Research Methodology

A Detailed Study of Stem Cell Cartilage Regeneration Market includes the assessment of PORTERS Five Forces Analysis, PESTLE Analysis, Product Life Cycle Analysis, with Opportunity Maps. These analysis strategies can permit you to establish the highest competitive forces to form your business and to work out organization strategy. In this research study, we gathered, analyzed and interpreted records approximately Stem Cell Cartilage Regeneration market, approximately a product and its services, about the beyond and present commercial enterprise targets. This Market research includes two forms of data: Primary data which includes An institution survey and The in-depth interviews, Secondary Research Information assembled by means of media sources, exchange associations, government agencies, chambers of commerce, exertions unions, and so on. Secondary studies normally published in newsletters, pamphlets, magazines, alternate publications, and newspapers.

Highlights of Report:

1. Distribution Channel Assessment

2. Latest and Future Innovation Trends

3. Competitive Strategies

4. Niche Market Trends

5. Market Entry Analysis

6. Market Size and Forecasts

How is this Report On Stem Cell Cartilage Regeneration Market Useful?

In order to realize the understanding and insights acquired from this report, a few figures and presentations are also included other than the data. These are in the shape of charts, graphs, tables, etc. Rather than studying the raw data, studying through the equipment is less complicated and greater conclusions can be drawn looking at these explaining diagrams.

This report also offers hands-on ready-to-get right of entry to analytical facts furnished by enterprise professionals. They can recognize various essential trends, drivers, and demanding situations in the Stem Cell Cartilage Regeneration industry. This report will provide a detailed assessment of majorly the fundamental players, areas considered, and applications.

Contact Us:

Mr. Benni Johnson

MarketResearch.Biz (Powered By Prudour Pvt. Ltd.)

420 Lexington Avenue, Suite 300

New York City, NY 10170,

United States

Tel: +1 347 826 1876

Website:https://marketresearch.biz

Email ID:inquiry@marketresearch.biz

See the original post:
Stem Cell Cartilage Regeneration Market Key players, Geographical Regions and Growth Analysis Outlook Up To 2028 - Sound On Sound Fest

Scientists race to use zero gravity to kill the worst cancers – Big Think

By Stell Cell Research

Can being in zero gravity help beat cancer? A growing field of research, including an upcoming research mission to the International Space Station, is hoping to prove just that.

Joshua Chou, a biomedical engineer from the University of Technology Sydney in Australia, has conducted successful trials in a lab environment, and aims to establish that zero-g can kill cancer cells.

Zero gravity or weightlessness occurs in the absence of the sensation of weight, when no contact forces act upon an object (or a body).

Chou's work looks to pinpoint the sensors by which cancer cells find each other and grow into tumors within a body. He thinks these receptors are dependent on gravity and once it's removed, the cancer can be stopped as the cells won't be able to "sense" each other.

To study this approach further, a graduate student working with Chou created the first microgravity device in Australia. The apparatus is a tissue box-sized spinning container. The researcher described it as "something that looks like the pods astronauts train in."

Joshua Chou with a prototype of Australia's first microgravity device.

Photo by Sissy Reyes.

The device has allowed Chou's team to investigate how microgravity affects different diseases. The scientists report it has been tremendously effective so far in eliminating cancer cells.

Normally, these are the hardest cancers to fight. Chou's experiments, without using any drugs, managed to either kill such cells or make them "float off because they can no longer hold on."

Early in 2020, Chou and his team will be able to test their approach in space, launching a specially-designed module with the help of SpaceX. The module will be loaded with the four types of cancer cells (ovarian, breast, nose and lung). Once launched, the scientists will be able to monitor it from Earth via data feeds. The experiment is set to last seven days, after which the cells will be frozen and send back to Earth 21 days later on a shuttle. More studies will be conducted once the cells are back in the lab on the ground.

The research team, from left, Chelsea Ly, Carin Basirun, Jessica Domingo and Joshua Chou.

Photo: Joshua Chou.

If Chou and his team succeed, does that mean cancer patients will be sent to space for treatment? While there may be such eventualities as well, Chou's vision is to develop a drug that patients can take while on Earth. He hopes to use it to "trick" cancer cells into behaving like they are in space.

Chou also thinks that this kind of therapy might not be a "magic bullet" that will work on its own, but rather in conjunction with existing treatments. "It could give current treatments like chemotherapy a big enough boost to kill the disease," he adds in a recent article.

Chou's research is not the only one of its kind. Nine research projects are going to study the effects of weightlessness on cancer aboard the new China Space Station (CSS), set for 2022. One such project is "Tumours in Space" that will look at how microgravity and cosmic radiation can affect the growth of tumors.

Tricia L. Larose from the Norwegian University of Science and Technology, who is the project's Principal Investigator, explained their goal:

Organoids are three-dimensional cancerous tumors that can form small structures mimicking different organs.

Scientists in other countries are also looking at utilizing gravity on cancer. In 2017, a German team, led by professor Daniela Grimm from the University of Magdeburg, studied the effects of space on thyroid cancer cells. This was, in fact, the third time Grimm's team sent such samples into space. Their objective, as Grimm expressed in an interview, is "to find growth-regulating proteins and certain receptors that express and secrete differently in space versus on Earth." If they can find such proteins and receptors, they can develop new drugs to treat the cancers back on our home planet.

The Influence of short-term #Microgravity on Human Prostate CancerThe Influence of short-term #Microgravity on Human Prostate Cancer Cells during a Parabolic Flight . By Prof. Daniela Grimm from University of Magdeburg . Dr...

Related Articles Around the Web

See the original post here:
Scientists race to use zero gravity to kill the worst cancers - Big Think

How technology has changed the world in the last decade – The Upcoming

By Stell Cell Research

How technology has changed the world in the last decade

Technology has changed the world in many ways during the last decade. Medicine- technology has enabled robots and remote location surgeries, it has reduced the chances of infection and disease, it has speeded up the process of delivering medicines and life-saving drugs.

Every day, technology is creating more breakthroughs to fight serious illnesses that have resulted in high mortality in the past. Stem cell research gives patients a new lease on life, as do artificial limbs.

Travelling

Gone are the days when we stood in line for tickets. No more talking on the phone with the travel agent for good deals. Now, travel is online and forever changed. You can go online to research your destination and find information you need. From where to stay to what to wear there, every piece of travel information can be found. Now, you can track a flight, train or car, you can use GPS to find a destination, you can book and cancel tickets online and plan your trip down to the exact minute.

Finance

When was the last time you went to a bank to pull out money or update your passbook? Hard to remember, isnt it? Technology has made the world of banking and finance accessible for everyone. You can do all your banking transactions online, keep an eye on your stock portfolio, and invest in funds of your liking.

Shopping and gaming

More and more people are choosing to shop online. Thanks to technology, huge retail chains have websites where you can buy anything from a pin to a plane. Customers are spoilt for choice, deals are almost irresistible, and delivery is hassle-free.

From fantasy league football to watching matches with high speed internet, the world of games and play has changed forever. Online gaming is exploding and gaining popularity every day. There are thousands and thousands of sites and apps offering new ways to experience games. Technology has brought all sorts of games, from augmented reality to even real money blackjack right to your home, to play, practise and excel.

Conservation

A vital topic on todays world, conservation efforts have benefitted from technology. From drone technology to monitor animals and birds, to embedded chips to keep track of movements and births, technology is helping dedicated people everywhere make the planet a better place. Ocean currents, rising temperatures, glacier cleavages, deforestation and afforestation- technology is helping us keep track of nature.

Entrepreneurship

There was a time when small and medium enterprises could not operate beyond local sales. Now, these sites have websites and more people are getting to know of them and their products and services. Companies have clients from all over the world, bringing valuable experience and expertise in its wake.

Social media

Social media has defined the decade for sure. From influencer behaviour, to finding new friends, social media presence has been ubiquitous. Instagram is a visual delight, Twitter is for clever repartee, and YouTube channels can teach you everything from how to cook to how to pitch a tent.

The editorial unit

Read the original:
How technology has changed the world in the last decade - The Upcoming

Stem Cell Market Analysis, Growth By Top Companies, Trends By Types And Application, Forecast Analysis To 2027 – Market Research Sheets

By Stell Cell Research

The study on the Global Stem Cell Market attempts to provide significant and detailed insights into the latest market scenario and the emerging growth prospects. The report on Stem Cell Market also emphasizes on market leading players as well as the new entrants in the market landscape. The expansive research will help the new top players as well as the well-established players to set up their business strategies and achieve their short-term and long-term goals and can make better decisions. The report also adds important details of the assessment of the scope of the geographies and where the key participants should move forward to find latest growth bussiness opportunities in the future.

Get the Inside Scoop and Research Methodology of this Sample Report

Scope of Stem Cell Market:

Primary and secondary data collection methods are used to collect the data from reliable sources across the globe that include key players, end users, suppliers, members of associations across the countries and end user industries.Advanced research techniques and tools are used to prepare the report that make this report accurate and up-to-date with latest industry trends.

The Report covers following things

Stem Cell Market: Segmentation

Segmental analysis is one of the key sections of this report. The authors of the report have segregated the Stem Cell market into product type, application, end user, and region. All the segments are studied on the basis of their CAGR, market share, and growth potential. In the regional analysis, the report highlights the regional markets having high growth potential. This clear and thorough assessment of the segments would help the players to focus on revenue generating areas of the Stem Cell market.

Highlight Of The Reports

Get Discount on this Report:https://www.worldwidemarketreports.com/check/discount/stem-cell-market-analysis,-growth-by-top-companies,-trends-by-types-and-application,-forecast-analysis-to-2027

Research objectives

To perceive the most influencing, pivoting and hindering forces in the Stem Cell Market and its footprint in the international market.

To gain a perceptive survey of the market and have an extensive interpretation of the Stem Cell Market and its materialistic landscape.

To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market.

To project the consumption of Stem Cell submarkets, with respect to key regions (along with their respective key countries).

To strategically profile the top key players and comprehensively analyze their growth strategies.

Important Stem Cell Market Data Available In This Report:

Emerging Opportunities, Competitive Landscape, Revenue Share of Main Manufacturers.

This Report Discusses the Stem Cell Market Summary; Market Scope Gives A Brief Outline of the Stem Cell Market.

Key Performing Regions (APAC, EMEA, Americas, Other) Along With Their Major Countries Are Detailed in This Stem Cell industry Report.

Company Profiles, Product Analysis, Marketing Strategies, Emerging Market Segments and Comprehensive Analysis of Stem Cell Market.

Stem Cell Market Share Year-Over-Year Growth of Key Players In Promising Regions.

Read more:
Stem Cell Market Analysis, Growth By Top Companies, Trends By Types And Application, Forecast Analysis To 2027 - Market Research Sheets

The most important health innovations of the past decade – The Hill

By Stem Cell Clinic

The 2010s are coming to an end, and looking back there have been some pretty amazing advances and innovations in health and science.

Advances in prosthetic limbs

Prosthetic limbs have been around since ancient times. In Egypt, a prosthetic wooden toe was found on a mummy dating back 3,000 years. By the Dark Ages, inventors could incorporate hinges on prosthetic arms used by knights. In modern times, the field of prosthetics has turned to incorporating more technology into physical stand-ins for limbs. In the last several years, theres been a boom in advances that have led to the best and most useful prosthetics weve ever seen.

Reports from the early 2010s talked about the potential for new technology to allow people to control prosthetics with their minds and to receive sensory information from their devices. It may have been a reach in the early part of the decade, but now it is literally within grasp. There are new prosthetic hands being tested that give the user the ability to grab objects with their thoughts and even to sense the texture of what they are touching. New bionic hands allow the user to feel again by sending signals back to the brain about the things they are touching, like whether its hard or soft. Other research groups have been working on bionic arms that can move based on the users thoughts through a brain-computer interface. While these have demonstrated its possible to accomplish these goals in the lab, theres still more to be done before people can use these devices outside in the real world.

Many of these advanced prosthetics are still prototypes and may not reach the general population for a while. Luckily, cheaper 3D printers have made simple prosthetics more accessible. These are important because a prosthetic device can improve the quality of life for people. For example, this person has been printing prosthetic hands and arms for people in Africa after watching an online tutorial. New materials that go into 3D printers are cheaper than they used to be and are being used in prosthetics to provide a more affordable option for patients.

Although prosthetics have been around for ages in some form or another, they arent always used. One variable to consider is the social acceptance of having a prosthetic. Theres still a lot of stigma around disabilities and many people may reject prosthetics even if they are available. In 2012, an athlete with both feet amputated competed in the mens 400 meter race at the Olympics in London. There was some controversy over whether the runner with a prosthetic foot should be allowed to run in races with people who dont have prosthetics or if they should only be allowed in competitions specifically for people who have them. Prosthetics also need to be comfortable and usable in order to be successfully adopted. In one study, about 4.5 percent of people rejected prosthetics and 13.4 percent stopped using their prosthetics. As the new prosthetics that are more natural and intuitive to use come to market, hopefully more people will benefit, and the social barriers to acceptance will disappear.

CRISPR

The genome modification technique called Clustered Regularly Interspaced Short Palindromic Repeats, aka CRISPR, was a culmination of a few decades of work by scientists, and major studies explaining the method were published in 2013. The version of it called CRISPR-associated protein 9 or CRIPSR-Cas9 is what most researchers are specifically using in most cases. It involves a regular gene editing mechanism that happens in bacteria. The bacteria can take sections of DNA from attacking viruses and essentially use that to remember the viruses if they return. When the virus is back, the bacteria can target the matching sections of DNA in the virus, cut it and disable the virus.

Though 2013 was only six years ago, as far as science goes, CRISPR has been moving at lightning speed towards practical applications. Using CRISPR to edit a gene sequence, researchers can now add, delete or modify DNA segments more quickly and accurately than ever before. Since the technique was developed, researchers have used CRISPR to target diseases caused by a single gene like cystic fibrosis or sickle cell disease.

Probably the most infamous use of CRISPR are the CRISPR babies. In late 2018, a Chinese researcher, He Jiankui, claimed to have used CRISPR to modify the genomes of two babies to include a mutated version of a gene that protects against HIV. This case was and is highly controversial for the ethical concerns with genetically modifying a human genome at the embryo level, or germline, meaning it can be passed down to future generations and has not been done before in humans. Recently, MIT Technology Review obtained excerpts from Hes research, and experts say that the report and data may be untrustworthy. This means it is still unclear if He and collaborators actually successfully modified the babies genomes. The scientific community overall condemns this way of using CRISPR to edit a human germline genome and has called for an international moratorium on it until a framework can be agreed on.The researcher has been sentenced to three years in prison in Shenzhen, China.

As fraught with controversy as the CRISPR babies may be, CRISPR technology still holds a lot of promise and can be used responsibly, supporters say. For example, researchers are using it to target cancer cells by taking a patients immune cells, modifying them using CRISPR and then infusing the patient with the modified cells. For blood diseases, a patient with sickle cell disease is reported to be responding well to a CRISPR treatment that has allowed her body to produce a crucial protein.

Another area that has boomed this decade partly because of CRISPR technology is stem cell therapy, which well get into in the next section.

Stem cell therapy

Technically, the only Federal Drug Administration (FDA)-approved stem cell therapies are blood-forming stem cells derived from umbilical cord blood. Blood-forming stem cells are used to treat patients with cancer after chemotherapy has depleted blood cells, as well as patients with blood disorders like leukemia whose bone marrow tissues are damaged. These types of treatments have been around for about 30 years, but in the 2010s weve seen potential for more uses of stem cells in health care.

The main idea behind stem cell therapy is that because the cells are pluripotent meaning they can become many other types of cells they can be introduced into parts of the body that are damaged and need new cells. On top of that, researchers can now extract some types of stem cells from a persons body, so no need for umbilical cords. This opens up the possibilities for highly personalized treatment where one person can be treated with stem cells from their own body.

Researchers are exploring how stem cells can be used to treat liver disease, cerebral palsy, stroke, brain injury and others. There are many ongoing research-backed clinical trials for stem cell therapy. A quick search for stem cell therapy on the governments clinical trial database turns up 5,638 results. And because of the work necessary to even get to the clinical trial stage, theres likely an order of magnitude more stem cell therapy studies in the pre-clinical trial stages.

Stem cell therapy is also being offered in for-profit clinics around the U.S. In these cases, the clinics are typically taking fat tissue from a patient, isolating the stem cells and then administering the stem cells back to the patient. In some cases, the treatments may lead to health complications, like blindness in a few extreme cases, and the FDA warns that such treatments are unapproved and potentially harmful. The FDA is ramping up regulation of stem cell clinics and earlier this year took a specific clinic in Florida to court.

Although there are many stem cell clinics offering unproven stem cell therapies, its not all hype. Granted that its difficult to pass the clinical trial stage to get FDA approval, stem cell research may lead to new treatments for several health conditions that could completely change the health care landscape.

You can follow Chia-Yi Hou on Twitter.

Here is the original post:
The most important health innovations of the past decade - The Hill

Hydrogel controls inflammation to speed healing – Futurity: Research News

By Stem Cell Clinic

Share this Article

You are free to share this article under the Attribution 4.0 International license.

Researchers have established a baseline set of injectable hydrogels that show promise to help heal wounds, deliver drugs, and treat cancer.

Critically, theyve analyzed how the chemically distinct hydrogels provoke the bodys inflammatory responseor not.

The researchers designed the hydrogels to be injectable and create a mimic of cellular scaffolds in a desired location. They serve as placeholders while the body naturally feeds new blood vessels and cells into the scaffold, which degrades over time to leave natural tissue in its place. Hydrogels can also carry chemical or biological prompts that determine the scaffolds structure or affinity to the surrounding tissue.

We dont want zero inflammation; we want appropriate inflammation.

The study demonstrates it should be possible to tune multidomain peptide hydrogels to produce appropriate inflammatory response for what theyre treating.

Weve been working on peptide-based hydrogels for a number of years and have produced about 100 different types, says Jeffrey Hartgerink, a chemist and bioengineer at Rice University. In this paper, we wanted to back up a bit and understand some of the fundamental ways in which they modify biological environments.

The researchers wanted to know specifically how synthetic hydrogels influence the environments inflammatory response. The two-year study offered the first opportunity to test a variety of biocompatible hydrogels for the levels of inflammatory response they trigger.

Usually, we think of inflammation as bad, Hartgerink says. Thats because inflammation is sometimes associated with pain, and nobody likes pain. But the inflammatory response is also extremely important for wound healing and in clearing infection.

We dont want zero inflammation; we want appropriate inflammation, he says. If we want to heal wounds, inflammation is good because it starts the process of rebuilding vasculature. It recruits all kinds of cells that are regenerative to that site.

The labs tested four basic hydrogel typestwo with positive charge and two negativeto see what kind of inflammation they would trigger. They discovered that positively charged hydrogels triggered a much stronger inflammatory response than negatively charged ones.

Among the positive materials, depending on the chemistry generating that charge, we can either generate a strong or a moderate inflammatory response, Hartgerink says. If youre going for wound-healing, you really want a moderate response, and we saw that in one of the four materials.

But if you want to go for a cancer treatment, the higher inflammatory response might be more effective, he says. For something like drug delivery, where inflammation is not helpful, one of the negatively charged materials might be better.

Basically, were laying the groundwork to understand how to develop materials around the inflammatory responses these materials provoke. That will give us our best chance of success.

Researchers at Texas Heart Institute (THI) helped analyze the cellular response to the hydrogels through multidimensional flow cytometry.

The results of this work lay the groundwork for specifically tailoring delivery of a therapeutic by a delivery vehicle that is functionally relevant and predictable, says Darren Woodside, vice president for research and director of the flow cytometry and imaging core at THI. Aside from delivering drugs, these hydrogels are also compatible with a variety of cell types.

One of the problems with stem cell therapies at present is that adoptively transferred cells dont necessarily stay in high numbers at the site of injection, he says. Mixing these relatively inert, negatively charged hydrogels with stem cells before injection may overcome this limitation.

Hartgerink says the work is foundational, rather than geared toward a specific application, but is important to the long-term goal of bringing synthetic hydrogels to the clinic.

We have been speculating about a lot of the things we think are good and true about this material, and we now have more of a sound mechanistic understanding of why they are, in fact, true, Hartgerink says.

The research appears in Biomaterials.

Additional coauthors are from Rice and the Texas Heart Institute. The National Institutes of Health, the Welch Foundation, the Mexican National Council for Science and Technology, the National Science Foundation, and a Stauffer-Rothrock Fellowship supported the research.

Source: Rice University

Continue reading here:
Hydrogel controls inflammation to speed healing - Futurity: Research News

Scientists are Working on a Way to Regrow Teeth in 2 Months – Science Times

By Adult Stem Cells

(Photo : pexels)

It is scary to think about losing your teeth, especially if you are an adult, but it is an issue that a lot of people face. Around aquarter of adultslose their teeth by the age of 74.

Although there are dental implants that can help, they can be very uncomfortable, especially since they do not adapt to the mouth as it ages. However, a new technique might help people to grow new teeth in just 2 months by using the patient's adult stem cells.

Regrow your teeth in 2 months

This discovery was published in August of 2019. Theresearchersfrom Columbia University Medical Center in New York City hope that they can get a patient's stem cells to grow an anatomically correct tooth.

Additionally, the new tooth will grow in a person's empty socket, even allowing it to merge with the surrounding gum tissue. They have already proven the ability to grow the teeth, however, after months of research and experiments, it is not available for humans yet.

The researchers conducted an experiment using 22 rats, according to theJournal of Dental Research. After the growth factors were implanted in the mouths of the rats, new bone material regenerated and integrated within 2 months. According to the researchers of the study, this is the first time that teeth-like structures have been regenerated in a living organism.

There can be a lot of benefits that come along with the new procedure if this treatment proves successful in humans. Since the tooth is grown in the socket where it will stay, there is also no need to harvest outside stem cells or make an outside environment for the tooth as it grows.

Because of this experiment, the researchers hope that this will be a better and more cost-effective solution for patients who can't afford dental implants. Also, since the tooth grows right in the mouth, there will likely be less recovery time and it will be less likely for teeth to fail.

However, for the time being, dental implants are the closest thing that we have to help replace lost teeth, Unfortunately, implants can be painful and it requires a long healing process, also it does not usually adapt to aging mouths which can cause the implant to fail.

Disadvantages of dental implants

The first disadvantage ofdental implantsis that they are expensive. Dental implants are not covered by dental insurance, if anything, they might help cover the restoration that will be attached to the dental implant such as the dental bridge, dental crown, and partial or full denture.

Another disadvantage of dental implants is that they need surgery to be placed. This may not be a big deal for some but keep in mind that surgery always has a health risk. The complication rate is just an average of 5 to 10%. The complications and risks of dental implants include damage to other teeth, infection, nerve damage, delayed bone healing, jaw fractures, prolonged bleeding and more.

With that said, this new alternative may become available soon. Even now, researchers at Columbia University have filedpatent applicationsfor this discovery and they are also looking at ways to make the process available commercially.

ALSO READ: Scientists Likely Found Way To Grow New Teeth For Patients

Excerpt from:
Scientists are Working on a Way to Regrow Teeth in 2 Months - Science Times

The ethics of lab-grown "minibrains" – Quartz

By Adult Stem Cells

For Alexander Fleming, leaving a petri dish out in the air led to his now famous discovery of antibiotics. For Madeline Lancaster, leaving stem cells in a shaker led to the discovery of a new model for neuroscience: brain organoids. These blobs of tissue, grown from human stem cells, resemble some of the essential parts of the human brain. Although they are as small as apple seeds, brain organoids may hold the key to understanding one of lifes great mysteries: the human brain.

Our brain is, arguably, the organ that most makes humans what we are. Our cerebral cortex, the outermost layer of the brain, underpins human cognition. When things go wrong in the cerebral cortex, either as we develop or as we age, this can cause neurological or psychiatric diseases. Neuroscientists have been trying to understand brain development and disease, but they have run into a pretty basic problem: We (usually) cannot collect brain tissue from living people. So neuroscientists arelimitedto studying tissue that is donated by those who have died or observing a living brain behave in an MRI.

To help fill in the gaps in our knowledge of the brain, scientists have turned to the proverbial lab rats (which are actually mice). Mice, rats, primates, and other animals have given scientists the chance to tease apart the roles of genes, molecules, and cells in brain development and disease. Some important insights were gained from these animals. Genetically engineered mice helped researchers understand how a protein called alpha-synucleincan misfold and clump together in theParkinsons-diseased brain, potentially injuring nerve cells. Research intoAlzheimers disease got a boost by mice that were genetically engineered to have mutations linked to Alzheimers. These mice have helped scientists understand how misfolded beta-amyloid proteins stick together in plaques in the brain, a hallmark of the disease.

But a mouse is not a human: mice do not behave as humans do; mouse brains are simpler than human brains; and the mouse genome is not the human genome. Researchers argue that modified mice or other animals do not reflect the complexity of humans, let alone the complexity of neurological or psychiatric conditions. For many conditions, researchers do not even know which gene defects are part of the underlying cause. Instead of creating a mouse that has the same gene defect as that found in human patients, researchers have had to make do with animal models that behave similarly to humans.

In one test for depression-like behavior, researchers hold mice upside down by their tail and measure how long they struggle against it. Mice that give up sooner are judged to show greater despair. But researchers are rightly skeptical. We can make models by challenging mice in different ways and looking at their behavior but its not at all clear that these animals have the same disease that we do, the neuroscientist Fred H. Gage, President of the Salk Institute for Biological Studies,said.

What then? Four millimeter brain organoids might seem an unlikely source for finding therapeutic breakthroughs for complex diseases. But much hope has been put into them since Madeline Lancasterpresented the first such minibrains in 2013. As with many scientific developments, her discovery had an element of serendipity, but cant be reduced to it.

Lancaster, then a postdoc in a Vienna laboratory, wanted to understand how developing brain cells switch from dividing, when they make more of themselves, to differentiation, when they turn into neurons or glia cells. To start off, Lancaster used techniques to coax stem cells, which can develop into pretty much any tissue, towards becoming neurons. But she had also been intrigued by the success of another research team, which grew mini-guts in Matrigel, a gelatinous protein mixture. So once Lancaster had coaxed the stem cells into becoming neural cells, she took clusters of them and put them into a drop of Matrigel. This gave the cells enough support to grow into larger and more complex structures.

Gently shaking the cells in a bioreactor, caused them to specialize into recognizable rudiments of the human brain. Within about two months, the brain organoids had grown structures similar to those found in the human brain, including the cerebral cortex, the seat of human cognition. Organoids also havegenetic similaritieswith the developing human brain. Moreover, many of the neurons in the organoids fired off electrical signals, the messages with which brain cells communicate.

Lancaster immediately realized one of the big promises of brain organoids: As stem cells are their starting material, researchers can take skin samples from adults and re-program those cells into stem cells. These then provide material for a personalized brain organoid. In their first presentation of organoids, the researchers grew personalized organoids from the skin cells of a person with microcephaly. Microcephaly, a condition where the brain is smaller than normal, is difficult to study using mouse models. The researchers took a step toward figuring out why neuron-producing cells stop their job too soon, which could ultimately result in too few neurons. When they added a copy of the faulty gene, the researchers grew organoids with more neuron-producing cells and, ultimately, more nerves.

Brain organoids certainly have their limitations: No two organoids are the same, potentially obscuring differences between personalized organoids. A lack of blood supply keeps the organoids small, as it limits the amount of oxygen that can get into their center. With about a couple of million neurons, a brain organoid has twice as many neurons as a cockroach, but far fewer than an adult zebrafish. Nevertheless, organoids have been used to investigate schizophrenia and autism, and scientists hope to use them to study a range of disorders, from Parkinsons to Alzheimers to eye conditions, like macular degeneration.

With time and intensive research, brain organoids are now better understood and being used in more complex experiments.One studyfound that organoids left to develop for 8 months formed neuronal circuits that sparked with activity, and grew light-sensitive neurons that responded when light was shone on them. Another lab has developedorganoids that produce brain waves similar to those of premature human babies.

Other researchers have developed workarounds to overcome the lack of blood supply. Inanother study, led by Fred Gage, neuroscientists transplanted human brain organoids straight into mouse brains. The organoids connected with the mouses blood supply, and connections between the human organoid and the animals brain sprouted.

This brings up ethical questions: the small blobs of brain tissue arent fully fledged brains, sitting in vats thinking about the meaning of life. The brain waves observed in some mature organoids alone are unlikely to be enough to produce complex brain functions. And, isolated from sensory input,it is unclear whether the organoids could even learn cognitive processes.

But implanting brain organoids into the brain of an actual living mouse could link the blob with the animals senses and motor system. These experiments hark to a related debate raging in science, about the creation and use of chimeras (animals into which human cells have been implanted). While in the US, the National Institutes of Health put in place a moratorium on funding research that investigates animal embryos containing human cells in 2015, in March 2019, Japanannounced a reversal of its ban, allowing scientists to grow human cells in animal embryos that are carried to term.

Arecent perspectivepublished inCellposited that, at the moment, the question isnt whether we humanize an animal into which a human brain organoid is implanted. Instead, it is important to ask whether the organoid enhances specific brain functions in the chimera, and at what point this enhancement crosses the line, becoming harmful and unethical. The authors argue that current studies are more likely to worsen brain function than to improve it.

At the moment, researchers need to make a surgical cavity to accommodate the organoid, which likely harms brain function. Once organoids can make up this deficit, which would be a notable achievement from a clinical perspective, and brain functions are enhanced above a critical threshold, perhaps the chimera should be given a higher moral status. This could go as far as giving the chimera the right of self-determination, the authors argue. Where this critical threshold lies is left open for debate, but the mirror test could be used to test for self-awareness in animals after organoid transplantation.

With brain organoids, the scientific community could be in danger of crossing yet another ethical line, some researchers warn. At this years meeting of the Society for Neuroscience, the largest annual meeting of neuroscientists, a group of scientists sounded the warning bell that research is coming close to creating sentient brain blobs in the lab, while some may have done so already.

The question here is at what point organoids, all on their own, develop consciousness or experience sentiments like pain. In 2018, a group of scientists, lawyers, ethicists, and philosophers, writing inNature,advocated for an ethical debate on brain organoids. With their initiative, they wanted to get ahead of the science, establishing guidelines before brain organoid research could raise immediate concerns.

At the meeting of the Society for Neuroscience, Elan Ohayon, director and founder of the Green Neuroscience Laboratory in San Diego, and his colleagues argued that serious concerns already have become reality. Ohayon presented a computer model which he believes helps to pinpoint when sentience is likely to arise. He suggests that some of the activity seen in organoids is reminiscent of the activity seen in developing animals and thatorganoid cultures may be capable of supporting sentient activity and behavior. Ohayon calls for a set of criteria to be applied to organoids that could help determine sentience and set ethical rules.

Brain organoids likely have a long way to go until they develop consciousness. And there is also likely a long way to go until they help researchers achieve therapeutic benefits. However, the promise of these blobs is so great that giving up brain organoid research altogethergiven the suffering caused by neurological and psychiatric diseases, and the lack of other modelscould itself be unethical. Whether or not any ethical lines have been crossed already, it is high time that neuroscientists, and society, come to terms with the question: What will organoids be able to tell us, and are we prepared to pay the price?

This article originally appeared on JSTOR Daily. Read the original here.

Go here to read the rest:
The ethics of lab-grown "minibrains" - Quartz

→←