Stem Cell Clinic

A primer: stem cell and regenerative medicine as ‘the’ emerging therapy – Chiropractic Economics

No longer just for professional athletes, these are the stem cell and regenerative medicine options DCs need to know about

The health care landscape continues to evolve at a dizzying pace. Insurance deductibles are increasing, and this has placed a financial burden on patients who are required to self-pay for necessary and yet uncovered services.

The opioid crisis has left physicians with limited clinical options to treat chronic pain and dysfunction. At the same time, pressure has been placed on health care providers to provide affordable alternatives to invasive procedures that provide limited clinical options with high failure rates. This confluence of supply and demand has resulted in the growth of emerging therapies in the field of stem cell and regenerative medicine. These therapies are bringing hope to patients and new opportunities to health care providers who deliver them.

Regenerative medicine is the process of replacing or regenerating cells and tissues to restore normal function. Initially popularized by professional athletes, these therapies have become mainstream. More than 27 million Americans suffer from osteoarthritis today, and in 2030 25% of U.S. adults will be diagnosed with osteoarthritis. The global regenerative medicine market is predicted to reach more than $100 billion by 2022.

These moderately-invasive regenerative procedures are eclipsing traditional highly-invasive procedures, such as hip and knee implantation, which will have a global market of $35 million over the same period.

There are four primary regenerative medicine options:

Irritant therapies include prolotherapy, ozone and prolozone. Theyincludeadding multipleirritatingsubstances along with numbing agents into degenerated or injured joints, and areas of pain.

These therapies cause inflammation to kick-start regeneration by stimulating the body to send in macrophages, which are cells that ingest and destroy theirritantsolution and trigger the healing response. Irritant therapies are an excellenttreatmentfor all forms of musculoskeletal and joint pain includingchronic neck and back pain, and rotator cuff injuries.

The effect of irritant therapies is analogous to jump-starting the battery in a tractor to get the engine to turn over.

Protease inhibition therapy eliminates the factors causing cartilage degradation, tissue breakdown, inflammation and pain. It cleans and protects joints. It is most commonly used for patients with osteoarthritis (OA) and degenerative disc disease (DDD).

It includes therapies such as alpha-2-macroglobulin (A2M) and interleukin-1 receptor antagonist protein (IRAP). A2M and IRAP are proteins found naturally in our blood. They act as protease inhibitors by binding to and inactivating damaging proteases in the body. Proteases are catabolic enzymes that break larger molecules into smaller units. Proteases trapped in the joints catabolize cartilage and break it down, causing arthritis. A2M is a large protein made in the liver. It blocks activity for all known molecules that cause cartilage breakdown. It works like a Venus flytrap by having a bait-and-trap mechanism on two sides.

Once the proteases are bound on both sides, the molecule initiates a suicide cascade and dies, allowing it to be flushed out of the area by the body.

The binding effect of protease inhibition therapy is analogous to de-weeding a garden and tilling the soil before planting.

A fibronectin-aggrecan complex test (FACT) may be used to determine the presence of FAC, which is a biomarker or indicator of cartilage breakdown caused by proteases. FAC is a unique molecular complex that is specific for painful inflammation of the spine and cartilage.

A small sample of fluid is taken from the joint or disc and sent to a lab for testing. The test looks for the presence of FAC in the fluid sample and determines where you are: FAC+ or FAC-. FAC+ patients are identified as ideal candidates for A2M injections and have a 90% rate of responding to the A2M therapy.

Stem cell therapy is focused on concentrating the workhorses of regeneration and restoration of tissues: stem cells. This results in greater cell signaling and cell recruitment than other regenerative therapies. Stem cells are known as mesenchymal signaling cells. They are considered pluripotent, which means they are undifferentiated and can replicate into various cell and tissue types.

Stem cells are found in bone marrow, the soft spongy tissue found at the center of large bones. Introducing stem cells into an injured area initiates the healing response, repairing damaged tissue by growing new, healthy tissue. The most common stem cell therapies include bone marrow aspirate concentrate (BMA), nanofat and stromal vascular fraction.

Injecting stem cells into an injured area is analogous to planting seeds in a garden.

Growth factor therapies are focused on cell signaling and cell recruitment. Blood is made up of white blood cells, red blood cells, and platelets that are suspended in plasma. Platelets are most widely known for their ability to clot blood. Platelets are also highly rich in growth factors that are proteins that stimulate healing. When an injury occurs, platelets become activated, migrate to the site of injury and release growth factors.

Growth factor therapies are the most popular provider choice for the low-cost regeneration of tissues and include platelet-rich plasma (PRP) and platelet-rich fibrin matrix (PRFM). The therapy includes drawing the patients blood followed by centrifugation to concentrate the platelets and exclude other unwanted blood products.

Another type of growth factor therapy is amniotic fluid growth factor (GF) injection therapy. Amniotic fluid surrounds the fetus during pregnancy and provides protection and nourishment. Human amniotic fluid is sourced from consenting mothers during full-term C-sections. It contains over 200 growth factors, cytokines and proteins. The therapeutic use of amniotic fluid is regulated by the FDA. It must be tested for disease and may not include any viable cells. Amniotic fluid GF therapy has both anti-inflammatory and anti-microbial properties and includes naturally-occurring hyaluronic acid for lubrication. It is most commonly used to promote the repair and reconstruction of soft tissues including cartilage and tendons.

Exosomes are being heralded as the next frontier of growth factor therapies. While they are not cells, exosomes play a vital role in the communication and rejuvenation of all the cells in the body. Exosomes are extracellular vesicles, or small bubbles, released from cells, especially from stem cells. These culture-expanded cell secretions are derived from human placental tissue. They allow for cell-to-cell communication, transporting molecules that are important regulators of intracellular information. Exosomes act as a food source for stem cells and prolong their activity. Exosomes are anti-inflammatory and include more than 300 growth factors, cytokines and proteins.

Patients with Lyme disease, burns, chronic inflammation, autoimmune disease and other chronic degenerative diseases may benefit from including exosomes in their treatment regimen. The application of growth factor therapies is analogous to applying fertilizer to a garden to help the crop grow and flourish.

Moving stem cell and regenerative medicine forward in the treatment algorithm may eliminate the need for other ineffective or potentially harmful therapies. These therapies provide new hope for patients whose only alternatives have been long-term medication, steroid injections, and costly and time-consuming surgery and rehab.

Stem cell and regenerative medicine therapies may only be provided by licensed medical professionals following all appropriate rules and regulations. An understanding of these emerging therapies and the benefits they may provide is essential as the collaboration between doctors of medicine and chiropractic increases and we join forces to combat chronic pain, dysfunction and disease.

MARK SANNA, DC, ACRB LEVEL II, FICC, is a member of the Chiropractic Summit and a board member of the Foundation for Chiropractic Progress. He is the president and CEO of BreakthroughCoaching, and can be reached at mybreakthrough.com or800-723-8423.

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A primer: stem cell and regenerative medicine as 'the' emerging therapy - Chiropractic Economics

Global Joint Pain Injections Market In-depth Outlook || Growing Popularity And Emerging Trends In The Industry – True Version

Joint Pain Injections Market Research: A combination of both Qualitative and Quantitative Research which helps out market players to improve their business plans and ensure long-term success

The latest report published by MarketResearch.Biz with the title GlobalJoint Pain Injections Market2019-2028 provides a sorted image of the Joint Pain Injections industry by analysis of research and information collected from various sources. That has the ability to help the decision-makers in the worldwide market and to play a significant role in making a gradual impact on the global economy. The report presents and offers a dynamic vision of the global scenario in terms of market size, market statistics, and the competitive situation.

Brief Overview OfJoint Pain InjectionsMarket Comprehensive Research Report Offering:

At present, the Joint Pain Injections market is possessing its presence over the globe. The Research report presents a complete judgment of the market which consists of future trends, growth factors, production volume, CAGR value, profit margin, price, and industry-validated market data. This report helps the individuals and the market competitors to predict future profitability and to make critical decisions for business growth.

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The report on Joint Pain Injections market gives the complete picture of demands and opportunities for the future that are beneficial for individuals and stakeholders in the market. This report determines the market value and the growth rate based on the key market dynamics as well as the growth of improving factors. The complete research is based on the recent industry news, market trends and growth probability. It also consists of a deep analysis of the market and competing scenarios along with the SWOT analysis of the well-known competitors.

The list of top key players operating in the Joint Pain Injections Industry includes:

Allergan Plc., Pfizer Inc, Sanofi, Anika Therapeutics Inc, Ferring B.V., Bioventus LLC, Flexion Therapeutics Inc, Zimmer Biomet Holdings Inc, Seikagaku Corporation, Chugai Pharmaceutical Co Ltd

These major key players have implemented multiple strategies such as possession, business development, and collaboration to achieve a leading position in the global market.

Joint Pain Injections Market Segmentation:

Segmentation by Injection type:

Corticosteroid InjectionsHyaluronic Acid InjectionsOthers (include, Platelet-rich plasma (PRP), Placental tissue matrix (PTM), etc.)Segmentation by joint type:

Knee & AnkleHip JointShoulder & ElbowFacet Joints of the SpineOthers (include, Ball and socket, etc.)Segmentation by end-user:

Hospital PharmaciesRetail PharmaciesOnline Pharmacies

The report focuses on market size and shares at the global level, company level, and regional level. The main regions analyzed in this report include North America, Europe, Asia Pacific, Latin America and the Middle East and Africa. These regions are playing a vital role in building the market structure by continuously concentrating on R & D activities and new progressions to obtain market share.

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3. It provides a 10-years forecast examined on the basis of how the market is predicted to grow over the globe.

4. It helps to understand the market by key players, segments (injection type, joint type, end-user, and region) and their future.

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Vampire facials and other medical witchcraft you can buy to stay youthful today – Citizen

You can maintain your youthful appearance and be less likely to have more invasive procedures later on in life if you put it effort to maintain the appearance. The same with skincare, if you put more effort now, with daily sunscreen, look after the skin and rejuvenate the skin, the likelihood of you having wrinkly sun-damaged skin later on is obviously much less.

This is the view of Dr Alexandra Grubnik, a plastic and reconstructive surgeon from Nip Tuck at the Netcare Milpark Hospital and Netcare Rosebank Hospital.

While surgical facial procedures are still being requested by South Africans, Dr Grubnik says there has been a rise in non-surgical procedures, with botox being one of the commonest procedures.

All the non-surgical procedures are done in rooms and theres absolutely no downtime. This is why theyre gaining popularity worldwide. There are people who say that in 20 years we will be doing no surgical operations.

A botox procedure involves injecting a serum that weakens the muscles to avoid getting wrinkles, while some use it to get rid of frown lines.

There is a very good twin study identical twins who participated in the study. One of them had regular botox injections every three to four months and the other just had it once upfront and did not have any for 10 years. The difference is absolutely remarkable. The other one without botox looks 20 years older than their sister, says Dr Grubnik.

This is sometimes confused with a filler, which is done to restore volume to the face and make it look more youthful.

As you age there is some resorption on the bone in the face, because theres bone loss and the soft tissues hang. When these people maintain themselves with filler, when they get to their 60s they may not need a facelift because they didnt have that droopiness that the previous generation would have had.

A filler injection (per millimetre) can cost you up to R3,000 each, while botox (per unit) is around R60.

A facelift, also common among South African women, is a procedure that involves removing excess facial skin from the lower half of the face including the chin and neck and tightening loose skin in different areas in the face.

According to Dr Grubnik, this is a big operation and requires recovery time.

There will be bruising, swelling in the face.

You can expect to pay around R95,000 for a facelift.

Also read: They do it for sexual satisfaction, says surgeon on rise in vaginal rejuvenation

Another common facial procedure in South Africa is blepharoplasty (eyelid surgery). This involves taking out excess skin in the upper and lower eyelid to remove bags in the eyelids.

Model and businesswoman Kim Kardashian shocked her social media followers a few years ago after telling them she regularly got vampire facials to keep her face looking younger.

The procedure has gained popularity among women, and Dr Grubnik says its because the procedure actually works.

A vampire facial involves taking blood from parts of your body (apart from the face), and spinning it to separate the red blood cells and the plasma.

In the plasma the platelets are in the blood. Its called platelet red plasma and this platelet red plasma is a stem cell. Stem cells have growth factors, so they rejuvenate the skin. We inject it in the face we can micro-needle it in the face.

Youre allowed to have it once every six weeks. It definitely works, theres a reason why Kim Kardashian is having it, explains Dr Grubnik.

A vampire treatment could cost you at least R3,300 per procedure and R4,200 with PRP (platelet-rich plasma) injections.

Other skin care procedures include acne and oily skin treatments (R880), skin brightening treatment (R880), hydrating treatment (R880) and the red carpet peel for R1,300.

While Dr Grubnik encourages the use of these procedures for those who are willing, she also advocates for good skin care with the use of a sunscreen.

Sunscreen is paramount because the sun damages skin skin quite badly, so before you know it you will have very bad wrinkles and sun damage with pigmentation, regardless of the skin tone or colour everybody suffers equally.

People say there is a genetic predisposition to how you age and, to a certain extent it is true. If your mother looks fantastic at 70, youre blessed with those genes as well, but its not only the genetics. Looking after yourself always makes a difference.

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Vampire facials and other medical witchcraft you can buy to stay youthful today - Citizen

Market Growth : Medical Aesthetic Devices Technologies and Global Market To 2022 – Downey Magazine

Recent research and the current scenario as well as future market potential of Medical Aesthetic Devices: Technologies and Global Markets.

The global market for medical aesthetic devices reached $13.5 billion in 2017 and is expected to reach nearly $25.1 billion by 2022 with a compound annual growth rate (CAGR) of 13.1% for the period of 2017-2022.

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Aesthetic medicine comprises all medical procedures that are aimed at improving the physical appearance and satisfaction of the patient, using non-invasive to minimally invasive cosmetic procedures. The aesthetic medicine specialty is not confined to dermatologists and plastic surgeons, as doctors of all specialties seek to offer services to address their patients aesthetic needs and desires. All aesthetic medicine procedures are performed under locoregional anesthesia.

The exciting field of aesthetic medicine is a new trend. Patients not only want to be in good health, they also want to enjoy life to the fullest, be fit and minimize the effects of natural aging. Indeed, patients are now requesting quick, non-invasive procedures with minor downtime and very little risk.

This recent trend explains the current success of aesthetic medicine around the globe. These aesthetic procedures consist of: Injections of neurotoxins and dermal fillers. Chemical peels. Cosmetic dermatology treatments. Microdermabrasion. Body contouring and treatment of cellulite. Nutrition. Hair transplant. Hair reduction. Fat grafting/platelet rich plasma. Laser and IPL. Scar management. Venous treatment.

Initially, concerning simple skin care and facial treatment, aesthetic medicine borrowed extensively from mainstream medicine. Fat grafts in orthopedics found new life as compatible long-term fillers to flesh out wrinkles in aging faces. Chemical peels removed dead skin cells, freeing up fresh ones to glow and grow. Botulinum, an R&D success, became a popular injection for removing wrinkles and creases.

Today, effective aesthetic medicine-as a minimally invasive practice-is based on doctors having skilled hands, whereby they leverage reliable, cutting-edge medical technology, such as laser technology, chemical peels, fillers and injectables of natural or bio-ingredients. It spans surface treatments through chemical peels and lasers to minimally invasive procedures, such as thread-lifts, botulinum type A injections, derma fillers, fat grafts and hair transplants.

Aesthetic medicine bridges the gap between beauty and health. It is important because beauty is not just skin deep. Beauty includes the need to feel good in ones own skin, thereby nurturing a psychophysical balance. We cannot ignore the importance of aesthetics from a psycho-sociological point of view, especially when todays society so highly covets attractive appearances. So, consumer patients are seeking aesthetic doctors to improve their appearance, and thus their self-confidence for social and/or professional reasons.

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Report Includes

36 tablesAn overview of the global markets and technologies for medical aesthetic devicesAnalyses of global market trends, with data from 2016 and 2017, and projections of compound annual growth rates (CAGRs) through 2022Discussion of the properties and characteristics of human skin, hair, and breastsDescription of medical devices, including botulinum neuromodulators, breast augmentation devices, and injectable dermal fillersCoverage of devices for assisted liposuction using ultrasound, light, or waterInsight into the regulatory environment for medical devices and drugs in the U.S. and EuropeComprehensive company profiles of major players in the market, including Allergan PLC, Cutera, Inc, El. En. Group, Hologic, Inc, Implatech Implant Teknolojileri and Johnson and Johnson

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Market Growth : Medical Aesthetic Devices Technologies and Global Market To 2022 - Downey Magazine