Stem cell research is a good thing | Opinion – Chart

Stem cell research is becoming more of a taboo topic as many people of the United States move into a seemingly more anti-abortion stance.

Stem cells come from a fetus that is between three to five days old (the clump of cells is called a blastocyst at this point) and can be used to reverse the effects of chemotherapy, and help repair damaged muscle.

According to the Mayo Clinic, stem cell research and transplants can also replace neurons damaged by any spinal cord injustices, improve the symptoms of Alzheimers and Parkinsons, and produce insulin to help people with diabetes. Adult stem cells can be used as well, but they are not as useful and can only be used to work with certain types of tissues, unlike the cells of a fetus which are more malleable.

According to the California Institute for Regenerative Medicine, the cells from these fetuses are donated with full consent from the donors and are from cells that were created by in vitro fertilization at various medical research clinics. Stem cells can also be collected from the placenta of a new born baby.

Stem cell research is viewed by a lot of people as the destruction of a human fetus, and that could not be farther from the truth. At three to five days old, a fetus is just a clump of cells.

It has no distinct characteristics other than it is made from the same cells as humans are. Many people think that it is unethical because these cells are possible humans, and instead of being used to create life, it is used for something completely different.

Lets say that we cut off all funding for research having to do with stem cells, including medical procedures using stem cells to repair parts of the body. This would prohibit many people from getting their bodies back to normal after receiving intense chemotherapy treatment, or due to being affected by a neurological disease.

The benefits of this type of research helps so many people that it would be ridiculous to choose a clump of cells over helping people who have been on this earth, making a difference in their own ways. It is inhumane to pick something so small, over helping a human obtain better quality of life.

It is understandable why people would be so against this, but the pros far outweigh the cons. It is an amazing scientific discovery that scientists can take new, healthy cells, and use them to repair damage.

The people against it should stop and think about how many lives can be changed or possibly saved in the future with more testing being done. It is amazing that scientists have even found out that it was possible to use cells to repair parts of the body that have been damaged.

Just imagine what kind of scientific discoveries scientists will be able to make in 10 years from now that could completely change our lives. It all starts with discoveries like this.

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Stem cell research is a good thing | Opinion - Chart

Understanding When and How to Treat Inflammation – Flagstaff Business & Online News | Northern Arizona Local Newspaper – Flagstaff Business News

Its drilled into our heads over and over. Inflammation is bad! Take this anti-inflammatory medicine! Inflammation is the enemy! Stop it in its tracks!

But, is inflammation always the enemy?

Lets start by talking about the difference between acute and chronic inflammation. Acute inflammation generally happens after an injury and has the symptoms of redness, heat, swelling and pain. It really shouldnt last longer than four to six weeks and I think of it as a healing response. Having a fever during an acute illness, such as a cold or flu, is also an example of acute inflammation.

Chronic inflammation lasts longer than six weeks and, generally, I think of any inflammation lasting longer than six weeks as a degenerative response. This means that the tennis elbow that youve had for two years has transitioned from the initial (acute) healing response to a dysfunctional response where the tendons in that elbow are degenerating or slowly breaking down. The breakdown of tissue is what causes pain, not necessarily inflammation.

Chronic inflammation also occurs with conditions such as rheumatoid arthritis, Hashimotos thyroiditis, chronic fatigue and fibromyalgia. This type of inflammation is not productive and people with these conditions need to discover the cause. Its not easy to discover the causes of this type of inflammation, so your best bet is to see a naturopathic physician.

Naturopathic physicians are the best trained healthcare providers to look at a person as a whole and discover the multifactorial causes of chronic inflammation. Naturopathic physicians prefer to use natural treatments to alleviate symptoms and address the cause of chronic inflammation, but may also use conventional medications.

What purpose does acute inflammation serve?

In an acute injury, such as an ankle sprain, your body sends all types of help to the injured area. This help includes white blood cells, cytokines, growth factors and other types of cells that participate in the inflammatory response. The upside is that these helpers will assist in healing the injured area. The downside is that the injured area may be painful, swollen and red. Take these symptoms as a signal from your body to slow down and let that area heal!

If we are using fever as an example, your immune system kicks in and raises your body temperature in response to a virus, bacteria or other type of infection. This rise in temperature may kill some bacteria or viruses. Fever also triggers certain immune cells in your body to become more active so that they can battle the infection that is happening. We all have uncomfortable symptoms when we have a fever. Again, take these symptoms as a signal from your body to slow down and heal.

The mistake that most of us make is taking big steps to interfere with our natural inflammatory (healing) response. We will ice an injured area or take an anti-inflammatory medication when an injury or fever happens. When dealing with an injury, the long-outdated advice of RICE (rest, ice, compression and elevation), combined with popping an anti-inflammatory medication such as aspirin, ibuprofen or naproxen shuts down your bodys innate ability to heal. The injured area has little chance of healing properly and may always be an area of weakness. In the case of an acute illness, a person may be sick longer than he or she would have been if the fever had been allowed to run its course.

Most people with a fever will see it resolve in a handful of days or less with minimal intervention, so I would like to focus on strategies that can be undertaken if you have an acute injury and just cant deal with the symptoms, or if you need to heal an area that has transitioned from inflammation to degeneration.

Herbal medicines such as boswellia, turmeric, corydalis and hops can modulate inflammation and decrease pain.

Acupuncture is a well-known treatment that alleviates pain and promotes healing.

Nutritional therapy in the form of intravenous (IV) nutrients or supplements can be useful to address nutritional deficiencies that prevent the healing process from working its best.

Diet provides the foundation to keep your immune system in tip-top shape. Eating a Standard American Diet (SAD) full of processed foods and sugar works against your immune system performing its best.

Regenerative injections such as dextrose prolotherapy and platelet rich plasma therapy (PRP) are my forte. These types of injections are a powerful tool to stimulate the immune response to allow the body to repair injuries, arthritis and other painful areas. This results in improved function and less pain. FBN

By Amber Belt, N.D.

Amber Belt, N.D. is a naturopathic physician with sharp regenerative injection skills, roller derby enthusiast, business owner, animal lover and Flagstaff devotee. Shes been performing regenerative injections for 12 years and can be contacted through aspenmedcenter.com or at 928-213-5828.

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Understanding When and How to Treat Inflammation - Flagstaff Business & Online News | Northern Arizona Local Newspaper - Flagstaff Business News

Sen. Tom Cotton: Contraband cell phones in prisons are a threat Congress should act on – Fox News

Earlier this year, we learned that Martin Shkreli, a conman and convicted felon, was secretly running an investment company from prison using a contraband cell phone.

Shkreli, also known as the Pharma Bro, achieved infamy in 2015 for jacking up the price of a medicine needed by a small group of very sick patients to enrich himself and his investors. He was convicted of fraud in 2017 and sent to prison.

Prison is supposed to keep criminals out of our communities, but as Shkrelis example shows, contraband cell phones allow inmates to continue their crime sprees from behind bars. Jamming cell phone signals from prison is the most effective way to counteract this dangerous trend. But first, the federal government has to let us do it.

FLORIDA MOM, DAUGHTER SENT CONTRABAND TO PRISON VIA DRONE DELIVERY, DEPUTIES SAY

Contraband cell phones have quickly become inmates most dangerous connection to the outside world. As mobile phones have become cheaper and easier to conceal, theyve proliferated in prisons across the country, including in my home state, Arkansas.

A little over a decade ago, convicted drug dealer Charles Wilson drove off prison grounds near Lincoln County on a tractor, where he was whisked away by several accomplices waiting at a prearranged location. Wilson was only recaptured after a 10-day manhunt that wasted precious police resources and endangered law-abiding citizens in nearby towns. The Wilson gang plotted his escape using a cell phone smuggled to him by his daughter.

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Contraband cell phones were relatively rare when Wilson escaped in 2008, but theyve since become a favorite tool of incarcerated criminals. Its impossible to know how many cell phones are circulating within prison walls, but the number is easily in the thousands in my state alone. Arkansas correctional officers discovered 36 contraband cell phones in 2012; six years later, they discovered 1,637.

Prisoners use this contraband to circumvent official, monitored forms of communication and plot criminal activity. Contraband cell phones have been used to scam, blackmail, and even plot attacks on people outside prison walls. Captain Robert Johnson, a former officer at Lee Correctional Institution in South Carolina, was shot six times in his home by a gunman acting on orders from a prison inmate using a contraband cell phone. Johnson now campaigns full time to stop contraband cell phones in prison.

Prison authorities have responded to the flood of contraband with new technology and methods, including cell phone-detecting devices and enhanced screenings. These tools have uncovered thousands of contraband cell phones, but thousands more have slipped through the cracks. Tougher measures are needed to secure our prisons and keep law-abiding people safe.

Installing jammers in prisons would turn inmates cell phones into paperweights, disrupting their criminal networks and drying up a major source of contraband.

The most effective, proven method to stop contraband cell phones is to jam all phone signals within prison walls. Unfortunately, flawed federal regulations prevent state prison officials from jamming phone signals.

Some people fear that cell phone jammers could disrupt phone service for law-abiding people close to prisons. However, modern jamming technology can be narrowly targeted to minimize disruption to people outside of prison walls. Cell phone jammers installed at a South Carolina prison as part of an experiment earlier this year rendered phones useless inside prisoners cells, but didnt affect phones several feet from the cell window. Another test at a federal prison in Maryland came to the same conclusion.

Its time to fix the federal regulations that prohibit jamming technology and give prisons the tools they need to fight contraband. The Cellphone Jamming Reform Act, a bill I introduced earlier this year, would accomplish this goal by allowing prisons to block cell phone signals within their housing facilities.

CLICK HERE FOR THE ALL-NEW FOXBUSINESS.COM

Installing jammers in prisons would turn inmates cell phones into paperweights, disrupting their criminal networks and drying up a major source of contraband. Most important, the Cellphone Jamming Reform Act would ensure inmates contact with the outside world takes place on our terms, not theirs, limiting criminals opportunities to take advantage of law-abiding citizens.

Contraband cell phones have become the most serious security risk prisons face today, but they dont have to be. We have the ability to make our communities safer right now, if the federal government will just get out of the way.

CLICK HERE TO READ MORE BYSEN. TOM COTTON

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Sen. Tom Cotton: Contraband cell phones in prisons are a threat Congress should act on - Fox News

Scientists find timekeepers of gut’s immune system – Washington University School of Medicine in St. Louis

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Targeting such cells may lead to treatments for digestive ailments

An immune cell that helps set the daily rhythms of the digestive system has been identified by researchers at Washington University School of Medicine in St. Louis. The findings open the door to new treatments for digestive ailments targeting such cells.

As people go through their daily and nightly routines, their digestive tracts follow a routine, too: digesting food and absorbing nutrients during waking hours, and replenishing worn-out cells during sleep. Shift work and jet lag can knock sleep schedules and digestive rhythms out of whack. Such disruptions have been linked to increased risk of intestinal infections, obesity, inflammatory bowel disease and colorectal cancer, among others.

Now, researchers at Washington University School of Medicine in St. Louis have identified a type of immune cell that helps keep time in the gut. Such cells, known as type 3 innate lymphoid cells (ILC3), are responsible for keeping the intestine operating in a normal, healthy manner. The researchers found that so-called clock genes are highly active in such cells and that the cells production of immune molecules track with the activity of the clock genes. When the researchers eliminated a key clock gene from mice, the animals failed to produce a subset of ILC3 cells and struggled to control a bacterial infection in the gut.

The findings, published Oct. 4 in Science Immunology, help explain why disruptions to circadian rhythms are linked to gastrointestinal problems. Further, they suggest that targeting clock genes could affect immune cells and help counter the negative effects of erratic sleep schedules associated with intestinal illnesses.

Its become increasingly clear that the disruptions of circadian rhythms so common in modern life shift work, jet lag, chronic sleep deprivation have harmful effects on peoples health, but we still dont know a lot about how exactly sleep disruptions cause these problems, said senior author Marco Colonna, MD, the Robert Rock Belliveau MD Professor of Pathology and a professor of medicine. What weve found here is that circadian rhythms directly affect the function of immune cells in the gut, which could help explain some of the health issues we see, such as inflammatory bowel disease and metabolic syndrome.

ILC3 cells maintain equilibrium in the gut by fortifying the barrier between the trillions of bacteria that normally live inside the gut and the cells that make up the intestine itself. They also produce immune molecules that help the guts immune system avoid overreacting to harmless microbes and food particles, while preserving its ability to combat disease-causing micro-organisms.

Colonna and colleagues have studied ILC3 cells for years, but it wasnt until first author Qianli Wang and second author Michelle Robinette, MD, PhD both graduate students in Colonnas lab at the time noticed that clock genes were highly activated in ILC3 cells that they began to wonder whether the cells could link circadian rhythms to the guts immune system.

If ILC3 cells are attuned to circadian rhythms, they can anticipate when nutrition is going to arrive in the intestine, which is also when dangerous bacteria might accidentally be consumed and arrive in the gut, too, Wang said. For optimal functioning, the gut needs to be prepared for these daily rhythms, and these cells play a pivotal role in that process.

By studying ILC3 cells taken from mouse intestines at six-hour intervals, the researchers found that the activity of clock genes varied in a predictable pattern over the course of a day, and that the activity of genes for immune molecules tracked with the clock genes. When they put some mice on a schedule similar to one experienced by a shift worker an eight-hour change in the light-dark cycle every two days the ILC3 cells no longer functioned normally. They produced low levels of immune molecules when stimulated to respond to an infection. Further, when mice were genetically modified to lack the clock protein REV-ERB alpha, the animals failed to develop normal quantities of ILC3 cells.

I think its fair to say that ILC3 is under circadian rhythm regulation and certain key circadian genes are crucial for ILC3 cells to develop and function, Wang said.

Wang and Colonna suspected that a paucity of ILC3 cells or a change in ILC3 behavior could affect the bodys ability to fight intestinal infections. Using mice that lack the clock protein as well as healthy mice for comparison the researchers studied the effect of infection with the bacterium Clostridium difficile, which can cause severe diarrhea in people. The mice without the clock protein failed to mount an effective defense: Their ILC3 cells produced more of a damaging immune molecule and less of a protective immune molecule, and the bacteria spread more widely in their bodies.

The equilibrium of the gut is upset by disruptions to circadian rhythms, Wang said. ILC3 cells are so important to gut equilibrium that we may be able to counter some of these disruptions by targeting clock genes in ILC3 cells.

The researchers are continuing to study the role of circadian rhythms on the digestive tract.

The emerging relevance of the circadian regulation in gut health is likely to impact medical and hospital practice, Colonna said. I think we will have to start taking circadian rhythms of the gut cells into consideration when choosing optimal timing for nutritional and pharmacological interventions.

Wang Q, Robinette ML, Billon C, Collins PL, Bando JK, Fachi JL, Scca C, Porter SI, Saini A, Gilfillan S, Solt LA, Musiek ES, Oltz EM, Burris TP, Colonna M. Circadian rhythmdependent and circadian rhythmindependent impacts of the molecular clock on type 3 innate lymphoid cells. Science Immunology. Oct. 4, 2019. DOI: 10.1126/sciimmunol.aay7501

This study was supported by the National Institutes of Health (NIH), grant numbers AI095542, DE025884, AI134236, AI134035, MH092769, K99 DK118110, and T32 GM007200; Pfizer; Crohns & Colitis Foundation; and anonymous donors.

Washington University School of Medicines 1,500 faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Childrens hospitals. The School of Medicine is a leader in medical research, teaching and patient care, ranking among the top 10 medical schools in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Childrens hospitals, the School of Medicine is linked to BJC HealthCare.

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Scientists find timekeepers of gut's immune system - Washington University School of Medicine in St. Louis

Novartis and Microsoft Team Up to Advance Medicine with AI – FinSMEs

Novartis(SWX: NOVN), a multinational pharmaceutical company based in Basel, Switzerland, is launching an AI innovation lab to enable its associates to use AI across the business.

The company selected Microsoft Corp. as its strategic AI and data-science partner. The new lab aims to bolster Novartis AI capabilities from research through commercialization and accelerate the discovery and development of transformative medicines for patients worldwide.

As part of the strategic collaboration, Novartis and Microsoft have committed to a multi-year research and development effort. The lab will bring AI to Novartis associates. By bringing together vast amounts of Novartis datasets with Microsofts advanced AI solutions, it will create new AI models and applications that can augment associates capabilities to take on the next wave of challenges in medicine.The lab will use AI to tackle hard computational challenges within the life sciences, starting with generative chemistry, image segmentation & analysis for smart and personalized delivery of therapies, and optimization of cell and gene therapies at scale.

Microsoft and Novartis will also collaborate to develop and apply next-generation AI platforms and processes that support future programs across these two focus areas. The overall investment will include project funding, subject-matter experts, technology, and tools.

Joint research activities will include co-working environments on Novartis Campus (Switzerland), at Novartis Global Service Center in Dublin, and at Microsoft Research Lab (UK) starting with tackling personalized therapies for macular degeneration; cell & gene therapy; and drug designBasel, and Redmond.

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Novartis and Microsoft Team Up to Advance Medicine with AI - FinSMEs

Evaluation Of Mean Platelet Volume, Red Cell Distributed Width And Neu | NDT – Dove Medical Press

Hasan Bykaslan,1 Mehmet Asolu2

1Department of Emergency Medicine, Harran University Medical Faculty, Sanliurfa, Turkey; 2Psychiatry Department, Harran University Medical Faculty, Sanliurfa, Turkey

Correspondence: Hasan BykaslanDepartment of Emergency Medicine, Harran University Medical Faculty, Sanliurfa, TurkeyTel +90 530 644 6845Email hasanbuyukaslan@hotmail.com

Background: The pathophysiology of conversion disorder (CD) is still not fully established. Many psychiatric disorders are known to be associated with inflammatory processes. We aimed to compare the routine hemogram values of CD patients with those of the participants in the healthy control group, to assess the inflammation levels of the two groups.Methods: This study was conducted with CD patients (n=158) and healthy controls (n=145). Routine hematological parameters were examined in each participant. Group comparisons were made with MannWhitney U-test and Students t-test. Regression analysis and receiver operating curve (ROC) analysis were also performed for the analysis of independent predictors.Results: The comparisons revealed that while neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet, neutrophil, red cell distribution width (RDW), and mean platelet volume (MPV) were significantly higher in CD group (P<0.05), lymphocyte was decreased in that group (P>0.05). Multivariate and ROC analyses showed MPV, RDW, and NLR as independent predictors (P<0.05). ROC curve showed that MPV values of 7.8 or above could predict the CD with 84% sensitivity and 85% specificity (area under curve [AUC]=0.878; 95% confidence interval [CI]: 0.8170.939), RDW values of 11.0 or above could predict the CD with 82% sensitivity and 73% specificity (AUC=0.871; 95% CI: 0.8150.926), and NLR values of 1.8 or above could predict the CD with 85% sensitivity and 78% specificity (AUC=0.865; 95% CI: 0.8020.929).Conclusion: CD is related to the acute inflammatory process. MPV, RDW, and NLR can reflect this inflammation. These parameters could be used in differential diagnosis; increased RDW and MPV levels can be used as a novel marker in CD.

Keywords: conversion disorder, inflammation, hematologic tests

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Evaluation Of Mean Platelet Volume, Red Cell Distributed Width And Neu | NDT - Dove Medical Press

On creativity, plasticity and repentance – Arutz Sheva

The young Israeli patient I visited in the isolation room at the Dana Farber Cancer Institute in Boston in the late 1970s was very ill. Ravages of the disease and its harsh treatment were clearly evident.

Diagnosed with a uniformly terminal disease, he had traveled to this renowned center in the Longwood Medical Area to be treated with a newly developed regimen of aggressive therapy. This world-famous academic hub is the medical campus where Harvard Medical School and many of its affiliated hospitals are all located. Major breakthroughs in medicine were developed here, including the first curative treatment of leukemia, the first kidney transplant, the first use of an electrical current to restore heart rhythm. It was here that creative man leaped forward with innovative advances that saved lives.

At the time I was a post-doctoral research fellow at Harvard Medical School. Our family resided several houses from the Ravs daughters home where the Rav was living, and our Maimonides community was fortunate to be able to spend eight to ten hours with the Rav every weekend in prayer and in learning. The creative gesture so central to the Ravs philosophy of halakhic man is a prime characteristic of biomedical research, and my oscillation between the universe of cutting edge biomedical research and the world of Torah learning with the Rav, while worlds apart, was harmonious. With the Rav often expressing curiosity about aspects of my research, I began to intuit that the work might not be merely creative but in fact a religious gesture.

A central theme in the Ravs weltanschauung is his emphasis on halakhic mans creative gesture. Ish haHalakhahs mission and continuous challenge are to heal and repair a purposely flawed world, for in the creation process a modicum of chaos was formed prior to the worlds creation and deliberately injected into both organic and inorganic matter, including into man himself.[1]

Man himself symbolizes, on the one hand, the most perfect and complete type of existence, the image of God, and, on the other hand, the most terrible chaos and void to reign over creation.[2] In order to enable man to cope with his inexorable chaos and sin, the tool of repentance was also created prior to the worlds formation (Pesahim 54a).

In a reference to creative introspection in Eight Chapters, Maimonides states: The perfect man needs to inspect his moral habits, weigh his actions, and reflect upon the state of his soul every single day. Whenever he sees his soul inkling toward one of the extremes, he should rush to cure it and not let the evil state become established (chap. 4).

Max Scheler, an early proponent of positive creative repentance, points out that modern philosophy, on the other hand, sees in retrospection and repentance mostly a negative, superfluous, uneconomical act due to disharmony of the mind and ascribed to lack of thought, sickness or various illusions..[3]

Emulating Maimonides, the Rav emphasizes an essential continuous remodeling, a re-creation of the sinners self as being a healthy, critically indispensable creative process. Halakhic man is engaged in self-creation, in creating a new I. He does not regret an irretrievably lost past but a past still in existence, one that stretches into and interpenetrates with the present and the future.[4]

The Ravs perspective on repentance is related to Schelers definition of creative repentance and to Henri Bergsons distinction between subjective, qualitative time-perception versus chronos, quantitative objective time. Both Scheler and Bergson ascribe to the principle of memory and experiential plasticity. The concept of plasticity, the property of being easily molded and remolded, has received intense scientific attention in the last decade, especially as related to the field of memory and neuroscience.

The presumed inability of the brain to generate new cells or to establish new neural networks is currently vigorously challenged and has indeed been proven incorrect. The process by which man can modify imprinted memories to affect his present and future behavior pattern is currently under scientific investigation. Epigenetic biochemical modifications of DNA and changes in neural networks triggered by ongoing experiences have been documented to alter both content and intensity of memories. The association between past triggering stimuli and the resurfacing of memories and behavior patterns has been shown to be moldable utilizing imaging and histological techniques. Previous memories can be reinforced, intensified, modified, or completely erased.

We no longer look at our genetic makeup and the mature brain as a fixed template that predicts our phenotype, and no longer are our memories an unalterable code. Rather, increasingly, biochemical data support the idea that they are templates upon which environmental and emotional stimuli can impact. Biochemical changes in the brain triggered by environmental and behavioral patterns were identified in identical twins raised in different environments. Scientists have defined conditions in which terminally differentiated cells, such as mature skin cells, which we assumed could never return to their embryonic pluripotent stem-cell status, have in fact definitively reverted and reprogrammed to evolve into new cell types. Recent reports have described the astonishing generation of live mice from skin cells reengineered to be ova.

If cells can revert to their embryonic state, if gene expression can be reprogrammed, if the brain can generate new nerve cells and establish new neural networks, the view of repentant man as a biologically defined new self is viable.

David Anderson from the California Institute of Technology describes a fascinating neuro-anatomical observation. The center in the brain that orchestrates emotion is the amygdala. It communicates with the hypothalamus, which houses the cells that control instinctive behavior like parenting, feeding, mating, fear, and fighting. Anderson found that a nucleus of cells within the hypothalamus contain two distinct populations of neurons: one that regulates aggression and one that regulates mating. About 20 percent of the cells in this nucleus are active both during mating activity and during aggressive behavior, which suggests that these two circuits are linked. How does the brain regulate these mutually exclusive behavior patterns? Anderson found that depending on the specific stimuli applied to this area it can trigger either mating activity or aggression.

Perhaps creating a new self through repentance from love (On Repentance, pp. 163) is associated with using mechanisms previously utilized for aggression and fear for productive activity such as love and fertility. A similar idea is found in the Babylonian Talmud (Shabbat 156a): He who is born under Mars will be a shedder of blood. Rabbi Ashi said: Either a surgeon, a thief, a slaughterer, or a circumciser. Through biochemical processes induced by the intense experiences of the teshuvah process confession, sacrifice, remorse, shame and a commitment to a new I a new self can emerge.

* * *

A decade after I visited the seriously ill young man at the Dana Farber Cancer Institute, the facility where chaos reigns and where creative man is faced with overwhelming challenges, I attended a scientific conference in Tiberias, burial place of Maimonides. I learned that a daily minyan was available at a nearby archeological site of an ancient synagogue on the shores of the magnificent Sea of Galilee. I was welcomed by a group of yeshiva students from Bnei Brak who had been coming weekly to maintain a minyan at this historical site.

Following services I was approached by a bearded man, who inquired:Are you Dr. Goldberg?

Since I had never practiced medicine in Israel I was surprised to be addressed as a physician.

Do you remember me? he asked. I am that patient you visited at the Dana Farber so many years ago. I am healthy, married and have several children.

The Prophets and the Torah as well recognized a strong connection between sin and illness on the one hand and between repentance and healing on the other (On Repentance, p. 80).

Through the creative gesture both the body and the spirit can be remodeled and healed.

Notes:

1. See Rabbi Joseph B. Soloveitchik, Halakhic Man (Philadelphia, 1983), p. 102.

2. Halakhic Man, p. 109.

3. Max Scheler, On the Eternal in Man (New Brunswick, NJ, 2010), p. 36.

4. Halakhic Man, p. 113.

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On creativity, plasticity and repentance - Arutz Sheva

UW Medicine receives $50 million donation to start brain institute – Lewiston Morning Tribune

SEATTLE A pair of philanthropists from Bellevue have given $50 million to UW Medicine to create an institute focused on developing treatments for brain disorders such as addiction, depression and Alzheimers disease.

The money, donated by Lynn and Mike Garvey, will kickstart the development of the Garvey Institute for Brain Health Solutions.

This will be the second neuroscience-focused institute in Seattle. The Allen Institute for Brain Science examines how the brain works, while the new Garvey Institute will take a more clinical approach to brain health. The work done at each could mesh nicely together, said Dr. Jrgen Untzer, a professor and chairman of UWs psychiatry and behavioral sciences department, which will be home to the Garvey Institute.

Garvey Institute researchers will build on work already being done at UW Medicine, and will also partner with scientists from within the University of Washington and other local health systems, Untzer said.

The goal is not only to develop brain solutions but to get them quickly put into practice, he said.

In addition to clinical research on treatments for brain disorders, the money will also fund training efforts for scientists and researchers from different disciplines at the institute, as well as a place for them to work together.

In its first five years, the Garvey Institute will focus on three main areas: cognitive aging and brain wellness; the effects of physical and emotional trauma on the brain; and addiction.

At some point, almost every family is affected by a brain-health problem such as depression, Alzheimers disease or addiction, Lynn Garvey said in the news release. These diseases are so common and so devastating, and we wanted to do something to help.

The Garveys, who declined to be interviewed, have previously donated money to UW Medicines Institute of Stem Cell and Regenerative Medicine, the psychiatry and behavioral sciences department, Harborview Medical Center, and the heart regeneration and gastroenterology programs.

Mike Garvey is the primary founder of Saltchuk, a Seattle-based family of transportation and distribution companies.

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UW Medicine receives $50 million donation to start brain institute - Lewiston Morning Tribune

UW Medicine receives $50 million donation to start institute to study addiction, Alzheimer’s and more – The Daily World

By Ryan Blethen

The Seattle Times

A pair of philanthropists from Bellevue have given $50 million to UW Medicine to create an institute focused on developing treatments for brain disorders such as addiction, depression and Alzheimers disease.

The money, donated by Lynn and Mike Garvey, will kickstart the development of the Garvey Institute for Brain Health Solutions.

This will be the second neuroscience-focused institute in Seattle. The Allen Institute for Brain Science examines how the brain works, while the new Garvey Institute will take a more clinical approach to brain health. The work done at each could mesh nicely together, said Dr. Jrgen Untzer, a professor and chair of UWs psychiatry and behavioral sciences department, which will be home to the Garvey Institute.

Garvey Institute researchers will build on work already being done at UW Medicine, and will also partner with scientists from within the University of Washington and other local health systems, Untzer said.

The goal is not only to develop brain solutions but to get them quickly put into practice, he said in an interview Wednesday.

In addition to clinical research on treatments for brain disorders, the money will also fund training efforts for scientists and researchers from different disciplines at the institute, as well as a place for them to work together.

These new programs will change the future of mental health and brain health in our region and beyond, Untzer said in a news release announcing the donation.

In its first five years, the Garvey Institute will focus on three main areas: cognitive aging and brain wellness, the effects of physical and emotional trauma on the brain, and addiction.

At some point, almost every family is affected by a brain-health problem such as depression, Alzheimers disease or addiction, Lynn Garvey said in the news release. These diseases are so common and so devastating, and we wanted to do something to help.

The Garveys, who declined to be interviewed, have previously donated money to UW Medicines Institute of Stem Cell and Regenerative Medicine, the psychiatry and behavioral sciences department, Harborview Medical Center, and the heart regeneration and gastroenterology programs.

Mike Garvey is the primary founder of Saltchuk, a Seattle-based family of transportation and distribution companies that reports a consolidated annual revenue of nearly $2.75 billion.

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UW Medicine receives $50 million donation to start institute to study addiction, Alzheimer's and more - The Daily World

American CryoStem Expands Investigator Team with Sub-Investigators for Post Concussive Syndrome IND – Yahoo Finance

The Company and the Principal Investigator announce the addition of sub-investigators to the clinical trial team with extensive experience assessing and treating athletes and military personnel suffering from concussion injury, traumatic brain injury and Post Concussion Syndrome

EATONTOWN, NJ / ACCESSWIRE / October 3, 2019 / American CryoStem Corporation (OTC PINK:CRYO) a leading strategic developer, marketer and global licensor of patented adipose tissue-based cellular products and technologies for the Regenerative and Personalized Medicine industries, today announced the selection of three new Investigators to assist the Principal Investigator with CRYO's Phase I clinical study of ATcell ("Investigational Drug") as part of a single center study under a protocol entitled: ATcell Expanded Autologous, Adipose-Derived Mesenchymal Stem Cells Deployed via Intravenous Infusion for the Treatment of Post Concussion Syndrome (PCS) in Retired Military and Athletes.

Dr. Tal David, a Sport Medicine specialist and former NFL Head Team Physician for the San Diego Chargers, is going to be the Co-Principal investigator for the study. Sub-Investigators, Dr. Jason Bailie, PhD, Senior Clinical Research Director at the Defense and Brain Injury Center (DVBIC) at the Naval Hospital Camp Pendleton, CA and Dr. Ettenhofer, Director of Research Operations, Defense and Veterans Brain Injury Center (DVBIC) Naval medical Center, San Diego, CA were the key designers of the evaluation aspect of the study. This included advising on the pre-treatment evaluations to rule out complex psychological co-pathology as well as the outcome measures to follow the efficacy of the treatments, since the chronic injuries seen in athletes mirrors those issues found in the military with multiple concussions and blast injuries.

Under the direction of Dr. Hanson and Dr. David, the sub-investigators will be responsible for assessing and screening all applicants for participation and completing the ongoing assessment of each participant. These evaluations include patient physical and neuropsychological assessment, testing and screening, preparation of source documentation and collection of assessment results, and assistance with completion of the final study reports and publications. The surgical tissue collection, ATcell treatments and follow up clinical visits will be conducted at BioSolutions Clinical Research Center facility in Le Masa, CA. The Company is pleased to present a world class team with significant experience in chronic concussion syndromes.

PRINCIPAL INVESTIGATOR: Dr. Peter Hanson, MD, as previously announced on September 11, 2019, has been appointed as the Principal Investigator, for the Company's study. Dr. Hanson is also Medical Director of BioSolutions Clinical Research Center the clinical research facility engaged by the Company to conduct the Study. During Dr. Hanson's career he has participated in approximately 41 clinical studies of which he led 24 as principal investigator. His clinical studies have been sponsored by many of the biggest names in the pharmaceutical and biotech industry such as Pfizer, Sanofi, Bristol Meyers Squibb, Regeneron, Cytori and InGeneron.

CO-PRINCIPAL INVESTIGATOR: Dr. Tal David, M.D. is a board-certified orthopedic surgeon specializing in arthroscopic and sports medicine surgery, is certified in both Orthopedic Surgery and Orthopedic Sports Medicine. He practices in San Diego, CA as part of the Synergy Specialists Medical Group and the San Diego Stem Cell Treatment Center. He is a clinical faculty member of Orthopedic Surgery at UC San Diego and a faculty member of the San Diego Arthroscopy and Sports Medicine Fellowship. He has cared for injured athletes for 15 years and has served on the medical staff of various professional sports teams including more than 11 years as an NFL team physician. In addition to his private practice, he served as the former Head Team Physician for the San Diego Chargers NFL football team and is Medical Director for the San Diego Gulls, AHL hockey team.

SUB-INVESTIGATOR: Jason M. Bailie, Ph.D, is a neuropsychologist who serves as Senior Clinical Research Director of the Defense and Veterans Brain Injury Center (DVBIC), Naval Hospital in Camp Pendleton, CA. Dr. Baille currently directs research, clinical and educational activities and supervises research staff. He is responsible for clinical research program development, experimental design, human-subject recruitment, experimental procedural implementation, data acquisition, and statistical analysis for local and multi-site research studies. Additional duties include oversight of research compliance with Institutional Review Board for the Department of Navy, Department of Defense clinical research and human subject research policies; and facilitating grant acquisitions and management. He supervises a clinical staff of social workers and psychologists, educational outreach personnel and provides educational presentations and grand rounds to providers and service members in collaboration with DVBIC Regional Education Coordinator.

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SUB-INVESTIGATOR Mark L. Ettenhofer, Ph.D is a neuropsychologist and Director of Research Operations American Hospital Services Group (AHSG), Defense and Veterans Brain Injury Center (DVBIC), Naval Medical Center, San Diego (NMCSD): San Diego, CA.Dr. Ettenhofer's primary research focuses on the development and evaluation of novel approaches for neurocognitive assessment and rehabilitation of traumatic brain injury (TBI) for the US Navy. Dr. Ettenhofer currently directs DVBIC supported traumatic brain injury (TBI) research at NMCSD, including 8 approved protocols evaluating novel technologies for TBI assessment, methods for remediation of TBI-related impairment, natural history of TBI, and guidelines for progressive return to activity after injury. Additionally he provides programmatic review for DVBIC national research portfolio, supervises and mentors eight full-time staff members in research activities and is well published.

Overall, it is estimated that the cost of traumatic brain injuries (TBI) in the United States weighs in at $48.3 billion annually of which $31.7 billion is spent on hospitalization costs; an additional $16.6 billion is associated with costs attributed to fatalities. According to the Center for Disease Control, acute care and rehabilitation of brain injury patients in the United States costs about $9 billion to $10 billion per year. This does not include indirect costs to society and family caretakers due to lost productivity, work time and earnings, as well as costs linked to providing social services.

Brain Injury Cost

The Company stated that "The successful assembly of this expert team of investigators who are currently treating athletes and military personnel suffering from Concussive and Traumatic Brain Injury is a major step towards properly implementing, monitoring and effectively evaluating the treatment of the participants with ATcell. Working with this expert team will expand the Company's knowledge for treating concussion injury, traumatic brain injury and Post Concussion Syndrome and accelerate its ability to complete this Phase 1 study and provide the necessary input to continue our work toward final FDA approval of ATcell for Post Concussion Syndrome.

For further detailed Corporate or Regenerative Medicine information please visit:

http://www.americancryostem.com, request by email at info@americancryostem.com or gathering phone 732-747-1007

This press release may contain forward-looking statements, including information about management's view of American CryoStem Corporation's ("the Company") future expectations, plans and prospects. In particular, when used in the preceding discussion, the words "believes," "expects," "intends," "plans," "anticipates," or "may," and similar conditional expressions are intended to identify forward-looking statements. Any statements made in this press release other than those of historical fact, about an action, event or development, are forward-looking statements. These statements involve known and unknown risks, uncertainties and other factors, which may cause the results of the Company, its subsidiaries and concepts to be materially different than those expressed or implied in such statements. Unknown or unpredictable factors also could have material adverse effects on the Company's future results. The forward-looking statements included in this press release are made only as of the date hereof. The Company cannot guarantee future results, levels of activity, performance or achievements. Accordingly, you should not place undue reliance on these forward-looking statements. Finally, the Company undertakes no obligation to update these statements after the date of this release, except as required by law, and also takes no obligation to update or correct information prepared by third parties that are not paid for by American CryoStem Corporation.

SOURCE: American CryoStem Corporation

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American CryoStem Expands Investigator Team with Sub-Investigators for Post Concussive Syndrome IND - Yahoo Finance