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Allogene Therapeutics Reports Third Quarter 2019 Financial Results – Yahoo Finance

SOUTH SAN FRANCISCO, Calif., Nov. 05, 2019 (GLOBE NEWSWIRE) -- Allogene Therapeutics, Inc. (ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T) therapies for cancer, today provided a corporate update and reported financial results for the quarter ended September 30, 2019.

I am very pleased with the progress we have made in a short period of time. While we leveraged the research from Pfizer to launch Allogene, we have built the company from the ground up. In parallel, we have initiated the build-out of in-house manufacturing capabilities, successfully progressed AlloCAR T programs into Phase 1 clinical development while creating next generation therapies and entering into agreements that will keep us at the forefront of cell therapy, said David Chang, M.D., Ph.D., President, CEO and Co-Founder of Allogene Therapeutics. With the initiation of our ALLO-715 Phase I UNIVERSAL trial in multiple myeloma, we have achieved all of the clinical goals that we set out for ourselves at the beginning of 2019. I am very proud of our teams accomplishments and firmly believe that the time and investment Allogene is making in research, next generation technologies, manufacturing and personnel will provide us with the key building blocks needed to support our goal of being the first to bring an AlloCAR T therapy to patients.

Pipeline HighlightsALLO-501 (anti-CD19 AlloCAR T)

ALLO-715 (anti-BCMA AlloCAR T)

Additional Pipeline Updates

Corporate Highlights

Third Quarter Financial Results

Conference Call and Webcast DetailsAllogene will host a live conference call and webcast today at 5:30 AM Pacific Time/8:30 AM Eastern Time to discuss financial results and provide a business update. To access the live conference call by telephone, please dial 1 (866) 940-5062 (U.S.) or 1 (409) 216-0618 (International). The conference ID number for the live call is 2747063. The webcast will be made available on the Company's website at http://www.allogene.com under the Investors tab in the News and Events section. Following the live audio webcast, a replay will be available on the Company's website for approximately 30 days.

About Allogene TherapeuticsAllogene Therapeutics, with headquarters inSouth San Francisco, is a clinical-stagebiotechnology company pioneering the development of allogeneic chimeric antigen receptor Tcell (AlloCAR T) therapies for cancer. Led by a world-class management team with significantexperience in cell therapy, Allogene is developing a pipeline of off-the-shelf CAR T cell therapycandidates with the goal of delivering readily available cell therapy on-demand, more reliably, and atgreater scale to more patients. For more information, please visitwww.allogene.com, and follow @AllogeneTx on Twitter and LinkedIn.

Cautionary Note on Forward-Looking Statements This press release contains forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The press release may, in some cases, use terms such as "predicts," "believes," "potential," "proposed," "continue," "estimates," "anticipates," "expects," "plans," "intends," "may," "could," "might," "will," "should" or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Forward-looking statements include statements regarding intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things: the timing and ability to progress the ALLO-501 ALPHA trial and ALLO-715 UNIVERSAL trial, the timing and Serviers ability to progress the CALM and PALL trials to potential registrational trials, the ability to manufacture AlloCAR T therapies, the ability to initiate and progress additional clinical trials of AlloCAR T therapies, the potential benefits of AlloCAR T therapy and the 2019 financial guidance. Various factors may cause differences between Allogenes expectations and actual results as discussed in greater detail in Allogenes filings with the Securities and Exchange Commission (SEC), including without limitation in its Form 10-Q for the quarter ended June 30, 2019. Any forward-looking statements that are made in this press release speak only as of the date of this press release. Allogene assumes no obligation to update the forward-looking statements whether as a result of new information, future events or otherwise, after the date of this press release.

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ALLOGENE THERAPEUTICS, INC.SELECTED FINANCIAL DATA(unaudited; in thousands, except share and per share data)

STATEMENTS OF OPERATIONS

SELECTED BALANCE SHEET DATA

Allogene Media/Investor Contact:Christine CassianoChief Communications Officer(714) 552-0326Christine.Cassiano@allogene.com

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Allogene Therapeutics Reports Third Quarter 2019 Financial Results - Yahoo Finance

50 years ago, cancer vaccines were a dream – Science News

Immune response and cancer therapy, Science News, November 8, 1969

The dream of a cancer vaccine is still just that a dream. But experimenters at Emory University in Atlanta have shown that the basic mechanism stimulation of an immune response can take place.

Researchers have devised several ways of getting the immune system to prevent or control cancer. Vaccinations against human papillomavirus, or HPV, prevent infections that cause cervical and other cancers. Hepatitis B vaccines may head off some forms of liver cancer.

Other strategies, like CAR-T cell therapy and PD-1 blockade therapy (SN: 7/11/15, p. 14), prompt T cells of the immune system to go after tumors. The U.S. Food and Drug Administration approved the first PD-1 blockade therapy in 2011 and then two CAR-T cell therapies in 2017 for patients with certain types of cancers (SN: 12/23/17 & 1/6/18, p. 29). Overstimulating the immune system can produce severe side effects, so scientists are working to develop safer options (SN: 7/7/18, p. 22).

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50 years ago, cancer vaccines were a dream - Science News

RESTORE Consortium to Host the 1st Advanced Therapies Science Meeting, Aiming to Translate Promising Research into a Game Changer in Healthcare -…

HAIFA, Israel, Nov. 04, 2019 (GLOBE NEWSWIRE) -- Pluristem Therapeutics Inc. (Nasdaq:PSTI) (TASE:PSTI), a leading regenerative medicine company developing novel placenta-based cell therapy products, today announced that the RESTORE Consortium is hosting its 1st Advanced Therapies Science Meeting (ATSM), which is being held November 25-26, 2019 in Berlin. As a leading member of the large-scale research initiative, Pluristem, along with additional respected members, is committed to accelerating the availability of advanced therapies to all those in need, a main motivation standing behind RESTORE.

Led by Charit-Universittsmedizin Berlin, and coordinated by Professor Hans-Dieter Volk from the BIH-Center for Regenerative Therapies in Berlin, RESTORE aims to promote groundbreaking research, drive Europe to the forefront in advanced therapies and deliver a pipeline of potentially transformative cures to patients in need. Advanced Therapies are a potential game changer in health care, aiming to shift our focus from chronic treatment of disease to regeneration of health, said Prof. Volk. We are determined to translate promising research findings into safe therapies, and we are working across disciplines and national borders in order to achieve this goal. The 1st Advanced Therapies Science Meeting provides the opportunity to discuss the still numerous obstacles in the way of implementing these promising therapies in routine clinical care.

This initiative may hold the key for changing the approach towards medicine in Europe, and advancing solutions for patients in need, said Zami Aberman, Executive Chairman of Pluristem. The European Commission is poised to make a significant investment of up to 1 billion in a consortium of companies that can drive forward the development of novel regenerative therapies, and we are pleased to be a leading part in this effort. Given our proprietary cell manufacturing technology and broad, late-stage pipeline, we believe we can play a key role toward making the transforming promise of advanced therapies into a reality.

The 1st ATSM will bring together experts from industry, patient organizations and academia to discuss the challenges within the field of advanced therapies, which include gene and cell therapies and tissue-engineering approaches. The ATSM is focused on trying to drive forward a concerted interdisciplinary effort, making use of science, infrastructure and funding within Europe to make regenerative therapies available to the broadest possible patient population.

The two-day program will include talks from Nobel Prize winner Ada Yonath (Director of Weizmann Institute of Science, Israel), Michele De Luca (University of Modena, Italy), Timothy OBrien (National University of Ireland, Galway, Ireland), Maksim Mamonkin (Baylor College of Medicine, USA), Manuela Gomes (University of Minho, Portugal) and others.

RESTORE partners include the Charit Universittsmedizin Berlin and Berlin Institute of Health (Germany), the University of Zurich (Switzerland), Cell and Gene Therapy Catapult (United Kingdom), TissUse GmbH (Germany), Pluristem (Israel), Miltenyi Biotec GmbH (Germany), INSERM Institut National de la Sant et de la Recherche (France), Innovation Acta S.r.l. (Italy), Fondazione Telethon Milan (Italy), and the University of Minho (Portugal).

About Pluristem TherapeuticsPluristem Therapeutics Inc. is a leading regenerative medicine company developing novel placenta-based cell therapy product candidates. The Company has reported robust clinical trial data in multiple indications for its patented PLX cell product candidates and is currently conducting late stage clinical trials in several indications. PLX cell product candidates are believed to release a range of therapeutic proteins in response to inflammation, ischemia, muscle trauma, hematological disorders and radiation damage. The cells are grown using the Company's proprietary three-dimensional expansion technology and can be administered to patients off-the-shelf, without tissue matching. Pluristem has a strong intellectual property position; a Company-owned and operated GMP-certified manufacturing and research facility; strategic relationships with major research institutions; and a seasoned management team.

Safe Harbor StatementThis press release contains express or implied forward-looking statements within the Private Securities Litigation Reform Act of 1995 and other U.S. Federal securities laws. For example, Pluristem is using forward-looking statements when it discusses the potential for the RESTORE Consortium to receive up to a 1 billion award by the European Commission and the timing of the potential award, that RESTOREs aim is to promote groundbreaking research, drive Europe to the forefront in advanced therapies and deliver a pipeline of potentially transformative cures to patients in need, that RESTORE and the 1st ATSM may hold the key for changing the approach towards medicine in Europe, and advancing solutions for patients in need, and its belief that given its proprietary cell manufacturing technology and broad, late-stage pipeline, it believes it can play a key role toward making the transforming promise of advanced therapies into a reality. These forward-looking statements and their implications are based on the current expectations of the management of Pluristem only, and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. The following factors, among others, could cause actual results to differ materially from those described in the forward-looking statements: changes in technology and market requirements; Pluristem may encounter delays or obstacles in launching and/or successfully completing its clinical trials; Pluristems products may not be approved by regulatory agencies, Pluristems technology may not be validated as it progresses further and its methods may not be accepted by the scientific community; Pluristem may be unable to retain or attract key employees whose knowledge is essential to the development of its products; unforeseen scientific difficulties may develop with Pluristems process; Pluristems products may wind up being more expensive than it anticipates; results in the laboratory may not translate to equally good results in real clinical settings; results of preclinical studies may not correlate with the results of human clinical trials; Pluristems patents may not be sufficient; Pluristems products may harm recipients; changes in legislation may adversely impact Pluristem; inability to timely develop and introduce new technologies, products and applications; loss of market share and pressure on pricing resulting from competition, which could cause the actual results or performance of Pluristem to differ materially from those contemplated in such forward-looking statements. Except as otherwise required by law, Pluristem undertakes no obligation to publicly release any revisions to these forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. For a more detailed description of the risks and uncertainties affecting Pluristem, reference is made to Pluristem's reports filed from time to time with the Securities and Exchange Commission.

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RESTORE Consortium to Host the 1st Advanced Therapies Science Meeting, Aiming to Translate Promising Research into a Game Changer in Healthcare -...

Cell Therapy Technologies Market Rising Demand | Impressive Business Opportunities, Analysis and Forecast by 2026 – Health News Office

A detailed segmentation-wise analysis included in the study highlights key segments of the Dental Imaging Market, and offers associated market numbers that allude at their growth potential at present as well as in the assessment period. Moving ahead, a regional study of the Dental Imaging Market has been offered to give a brief idea of opportune potential of various regional markets for sales of Dental Imaging .

Government expenditure on healthcare infrastructure and facilities continues on an upward spiral worldwide, in a bid to offer quality care to the increasing geriatric population and combat the rise of various communicable and non-communicable diseases. Additionally, there has been a remarkable rise in FDA approvals in the recent past. A paradigm shift is being witnessed in the pharmaceutical & healthcare industry, with leading companies putting efforts to combat key concerns, namely, intensifying competition, high cost of hiring skilled professionals, and lower reimbursements in Medicaid and Medicare.

ThisPress Release will help you to understand the Volume, growth with Impacting Trends. Click To get SAMPLE PDF (Including Full TOC, Table & Figures) athttps://www.persistencemarketresearch.com/samples/4447?source=atm

Notable transformations have been seen in the pharmaceutical & healthcare industry, which include the growing palpability of healthcare technology companies, increasing emphasis on reimbursements in innovative care delivery models, and the rise in virtual care. The legacy practices are undergoing drastic changes, as the focus on saving costs while improving patient outcomes continue to influence the industry dynamics.

The pharmaceutical & healthcare industry is entering a phase of turbulent growth, making its way through myriad challenges that include constantly growing drug prices, changing industry landscape influenced by rapid growth of biosimilar, confined R&D productivity, and healthcare technology disruptions.

Dental Imaging Market Report Summary

This Persistence Market Research report on the Dental Imaging Market gives a long-term viewpoint of the market during the forecast period. The main objective of the report is to offer readers with a broader perspective of the Dental Imaging Market so as to enable them in making factual decisions for triumphant growth of their business. Incisive insights into the Dental Imaging Market have been covered, along with a study of the market dynamics that have a notable impact on the market prospects.

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Some of the major companies operating in the global dental imaging market are Danaher Corporation, Carestream Health, Inc., Dentsply International Inc., LED Medical Diagnostics Inc., Yoshida Dental Mfg. Co., Ltd., Sirona Dental Systems, Inc., Planmeca Oy, Midmark Corporation, Vatech Co., Ltd., and FLOW Dental Corporation.

Key geographies evaluated in this report are:

Key features of this report

The report incorporates a scrutinized study of supply & demand patterns, pricing strategies of leading players, and supply chain of the Dental Imaging Market. Historical values have been offered for the period, which have been considered as the base for deducing forecast values of the Dental Imaging market. In order to make readers understand the volatility of the Dental Imaging Market, impact of past and current trends on the market growth has been covered in the report.

The report concludes with a brief assessment of the Dental Imaging Markets competitive landscape, wherein key companies that have a significant contribution to the market growth are identified & profiled in detail. Analysis on recent developments, R&D activities, innovative strategies, and product portfolio, has been offered for each player profiled in the report.

What does the Dental Imaging Market research hold for the readers?

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Persistence Market Research (PMR) is a third-platform research firm. Our research model is a unique collaboration of data analytics and market research methodology to help businesses achieve optimal performance.

To support companies in overcoming complex business challenges, we follow a multi-disciplinary approach. At PMR, we unite various data streams from multi-dimensional sources. By deploying real-time data collection, big data, and customer experience analytics, we deliver business intelligence for organizations of all sizes.

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Cell Therapy Technologies Market Rising Demand | Impressive Business Opportunities, Analysis and Forecast by 2026 - Health News Office

The Alliance for Regenerative Medicine Releases Q3 2019 Sector Report, Highlighting Industry Trends and Metrics – BioSpace

WASHINGTON, D.C., Nov. 05, 2019 (GLOBE NEWSWIRE) -- via NEWMEDIAWIRE -- The Alliance for Regenerative Medicine (ARM) today released its most recent quarterly sector report, offering an in-depth look at cell therapy, gene therapy, tissue engineering, and broader global regenerative medicine sector trends and metrics in the third quarter of 2019.

By further curating information provided by ARMs data partner Informa, the quarterly sector report details industry-specific statistics compiled from 959 cell therapy, gene therapy, tissue engineering, and other regenerative medicine therapeutic developers worldwide, including total financings, partnerships and other deals, clinical trial information, key clinical data events, and ARMs current strategic priorities.

Amanda Micklus, a senior consultant for Pharma Intelligence at Informa, provided an overview of the commercial, clinical, and regulatory environment in the third quarter of 2019. The report also features commentary from founding members of ARM in honor of the organizations 10-year anniversary. Excerpts from panels at ARMs 2019 Meeting on the Mesa included in the report highlight the continued progress and innovation in the sector.

Highlighted findings from the Q3 2019 data report include:

ARM will continue to update this information through new reports to be released after the close of each quarter, tracking sector performance, key financial information, clinical trials by phase, and significant clinical data events.

The report isavailable online here, with interactive data and downloadable graphics from the reportavailable here. For more information, please visitwww.alliancerm.orgor contact Lyndsey Scull at lscull@alliancerm.org.

About the Alliance for Regenerative Medicine

The Alliance for Regenerative Medicine (ARM) is an international multi-stakeholder advocacy organization that promotes legislative, regulatory and reimbursement initiatives necessary to facilitate access to life-giving advances in regenerative medicine worldwide. ARM also works to increase public understanding of the field and its potential to transform human healthcare, providing business development and investor outreach services to support the growth of its member companies and research organizations. Prior to the formation of ARM in 2009, there was no advocacy organization operating in Washington, D.C. to specifically represent the interests of the companies, research institutions, investors and patient groups that comprise the entire regenerative medicine community. Today, ARM has more than 350 members and is the leading global advocacy organization in this field. To learn more about ARM or to become a member, visithttp://www.alliancerm.org.

Lyndsey Scull202 213 7086lscull@alliancerm.org

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The Alliance for Regenerative Medicine Releases Q3 2019 Sector Report, Highlighting Industry Trends and Metrics - BioSpace

Cell lines and antibody commercialized through reagent licensing program – Nevada Today

The University of Nevada, Reno has partnered with the Boston-based reagent company Kerafast to help scientists worldwide gain access to the research tools developed in the Universitys laboratories. The program streamlines the process of transferring biomaterials among different research institutions, furthering the materials contribution to scientific progress.

Under the program, University researchers can add their lab-made materials to Kerafasts online catalog, where other scientists can easily access them via a simple-click license that eliminates the need for traditional Material Transfer Agreements (MTAs). Kerafast markets the materials, handles selling and shipping logistics, and returns a portion of the proceeds to the University and the contributing labs. The program aims to accelerate global scientific research, while also providing University labs with an extra stream of research funding.

Research materials from the first two University laboratories to participate in the program are now available online. Subhash Verma of the University of Nevada, Reno School of Medicines Department of Microbiology and Immunology has made available Burkitt lymphoma cell lines, useful for studying the oncogenic potential of viral antigen in causing B-cell lymphoma. In addition, Thomas Kozel of the same department has made available a monoclonal antibody for studying anthrax, a serious infectious disease and bioterrorism threat. The antibody detects poly--D-glutamic acid (PGA), a component of the anthrax bacterium that is shed into blood and can be used to rapidly diagnosis the infection.

The University of Nevada, Reno is committed to bringing the innovations and technologies developed on our campus into the marketplace for the benefit of society, said Ellen Purpus, assistant vice president for enterprise and innovation. Our new collaboration with Kerafast provides a streamlined path for our faculty to offer their reagents to the global research community. Kozel noted that the collaboration streamlines efforts to make key materials developed at the University available to the global research community.

We are excited to begin our partnership with University of Nevada, Reno, said Amelia Gibson, Kerafast business development director. The Kerafast mission is to advance life science research by promoting access to unique research tools, and we welcome UNR investigators into the rapidly growing community of scientists who are sharing novel materials through our program.

A wide variety of lab-made reagents including antibodies, proteins, cell lines, plasmids, nanoparticles, probes and more can be made available through this program. For more information, or to discuss distribution of research tools through the program, visit the Kerafast website or contact the office of Enterprise & Innovation at innovation@unr.edu or 775-784-4421.

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Cell lines and antibody commercialized through reagent licensing program - Nevada Today

Precision for Medicine and Akoya Partner to Develop Advanced Liquid Biopsy and Tissue Biomarker Tests – Yahoo Finance

MENLO PARK, Calif. & HOUSTON--(BUSINESS WIRE)--

Akoya Biosciences, The Spatial Biology Company today announced a strategic alliance with Precision for Medicine (formerly ApoCell), a pioneer in customized biomarker solutions, to develop proprietary liquid biopsy and tissue biomarker tests using Akoyas Vectra Polaris System. By combining the Vectra Polaris system with Precision for Medicines ApoStream technology, the collaboration is designed to advance immuno-oncology candidates in clinical trials using both tumor biopsies and liquid biopsies to generate data required for assessing drug efficacy and validation of companion diagnostics (CDx).

We are very excited to be the first commercial laboratory to launch the Vectra Polaris system for image analysis of circulating tumor cells following ApoStreams isolation and enrichment functionality, said Darren Davis, PhD, Precision for Medicine Senior Vice President. Together, these technologies will enable accelerated drug development through detection of biomarkers in liquid biopsies. These tools have enabled our scientists to better understand the biological correlation of circulating metastatic cancer cells with cancer cells present in the tumor tissue.

Circulating tumor cells (CTCs) have long been known to exist in cancer patients blood. However, the promise of clinical application of CTCs as a liquid biopsy has not born fruit because these cells are difficult to detect using current molecular biology techniques. Precision for Medicines proprietary ApoStream technology captures significant quantities of rare circulating cancer cells from whole blood for characterization using Akoyas Opal technology and Vectra Polaris imaging platform. ApoStream has been used in more than 80 clinical trials, including several ongoing phase III studies for CDx development.

Akoyas Vectra Polaris Automated Quantitative Pathology System, part of the companys Phenoptics 2.0 next-generation biomarker multiplexing platform, enables researchers to gain a deeper level of understanding of disease mechanisms related to new cancer immunotherapy approaches. The Vectra Polaris system integrates high throughput, seven-color multispectral imaging with whole-slide scanning in a simplified digital pathology workflow to support the quantification and analysis of tissue sections discernible with Opal detection kits. A recent meta-analysis of several studies showed that incorporating spatial information using Akoyas multiplexed immunofluorescence technology is important for improving the predictive accuracy of immuno-oncology biomarkers.

The Phenoptics portfolio is capable of interrogating multiple protein markers on any tissue or cytology slide preparation. Precision for Medicine has validated several immune biomarker panels across various therapeutic applications using both types of preparation. These immune panels are currently being used to monitor immune cell infiltration including cancer, psoriasis, lupus and atomic dermatitis.

The Vectra Polaris imaging system offers an innovative approach to assessing immunotherapy candidates in translational and clinical research, said Dr. Cliff Hoyt, Akoya Vice President of Translational and Scientific Affairs. We are pleased to see this technology paired with ApoStream for a comprehensive method of imaging CTCs and improving our understanding of disease mechanisms in cancer.

For more information on ApoCell and the ApoStream technology, please click here.

About Precision for Medicine

Precision for Medicine is the first biomarker-driven clinical research services organization supporting life sciences companies in the use of biomarkers essential to targeting patient treatments more precisely and effectively. Precision applies novel biomarker approaches to clinical research that take advantage of the latest advancements in science and technology, focusing predominantly on genomics, immune-response assays, global specimen logistics, biomarker analytics, companion diagnostics, and clinical trial execution. Precision for Medicine is part of Precision Medicine Group, with more than 1,900 employees in 34 locations in the US, Canada, and Europe. For more information, visit http://www.Precision for Medicine.com.

About Akoya

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Akoya Biosciences, The Spatial Biology Company, offers the most comprehensive, end-to-end solutions for high-parameter tissue analysis from discovery through clinical and translational research, enabling the development of more precise therapies for immuno-oncology and other drug development applications. The company has two industry-leading platforms that empower investigators and researchers to gain a deeper understanding of complex diseases such as cancer, and other immune system or neurological disorders. The CODEX system is the only benchtop platform that can efficiently quantify more than 40 biomarkers and is ideally suited for biomarker discovery. The Phenoptics platform is the only end-to-end multiplexed immunofluorescence solution with the robustness and high throughput necessary for translational research and clinical trials. For more information, please visit https://www.akoyabio.com/.

View source version on businesswire.com: https://www.businesswire.com/news/home/20191105005432/en/

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Precision for Medicine and Akoya Partner to Develop Advanced Liquid Biopsy and Tissue Biomarker Tests - Yahoo Finance