Best Anti-Aging Tips and Products for Skin and Hair – HarpersBAZAAR.com

Your Skin StrategyAT HOME

Ask any dermatologist and theyll all tell you the number-one thing you need to do for your face is to apply sunscreen daily. The bare minimum for future-proofing your skin is the consistent use of a sunscreen with a minimum SPF of 30, says Annie Chiu, M.D., a dermatologist in Redondo Beach, California. And even if you have an office job, you need to reapply. A lot of people think reapplication is only necessary with sweating or sports activity, but the correct way of dosing sunscreen is actually multiple times a day, Chiu says. To make it easy, use a makeup setting spray like Supergoop! x Rebecca Taylor Defense Refresh Setting Mist SPF 50 before heading out to lunch.

Adding a layer of antioxidant serum under your SPF acts like a safety net, helping to trap anything that gets through your sunscreen, says Miami dermatologist Joely Kaufman, M.D. Vitamin C is a great option, though many doctors suggest a cocktail of ingredients, like those in 37 Actives High Performance Anti-Aging and Firming Serum.

Of course, the nighttime element of your skin-care routine is just as important as the morning one. Retinol does a great job of building up collagen in the dermis, says Robert Anolik, M.D., a dermatologist in New York. It also prevents excess pigmentation formation in the epidermis. If retinol is too irritating for you, try bakuchiol, which is perfect for sensitive complexions. Its a botanical extract that helps activate the same retinoid receptors that retinol binds to, says New York dermatologist Joshua Zeichner, M.D. Find it in Burts Bees Renewal Intensive Firming Serum.

Repetitive movement can lead to dynamic wrinkles, like frown lines between the brows, Chiu says. This is where preventive Botox comes in. It keeps muscles from being overactive and lines from becoming permanent. Once wrinkles etch, meaning you can see them when your face is relaxed, its too late for products like Botox to have full benefit, explains Chiu. So when to start? You may want to consider it if you see the residue of a crease in the minutes after youve been very expressive, says Anolik.

Laser treatments offer the best way to address sun damage before it manifests as dark spots. For people whose skin looks dull, whose pores arent as tight as they used to be, or have some broken blood vessels, the Clear + Brilliant fractionated laser is great, says Kaufman. It takes off that sun-damaged outer layer and allows a new layer to come up. According to Kaufman, improvements are visible after one treatment.

At the first signs of sagging, think about booking a radio frequency or ultrasound skin-tightening session, such as Thermage or Ultherapy. These target the deeper collagen layers that have a lifting effect, Anolik says. And because youre not letting this collagen age as it naturally wants to, the rate at which you become more laxand the rate and timing of possible future plastic surgerywill slow.

In the end, its all about consistency. Doing your at-home routine twice a day should be like brushing your teeth, says Macrene Alexiades, M.D., a dermatologist in New York. And seeing me two or three times a year is similar to visiting the dentist for a deep clean.

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Its not all in your head. If you look at your college graduation pictures and swear that your hair used to be thicker, shinier, and generally more fabulous, youre right. Genetically were programmed to have our best hair when were most fertile, says New York dermatologist Doris Day, M.D. After your mid-20s, hair starts to lose its luster: Strands are thinner, less pigmented, and often coarse. On the bright side, pros say you can slowand even reversesome of the signs of aging. Heres how.

Not only do older hair follicles produce strands that are finer, but they also make fewer of them. This can translate into a skinnier ponytail, a wider part, or a more visible scalp. Most doctors suggest a multipronged approach. I usually give patients vitamins that address hair loss associated with stress or hormonal fluctuations, says Francesca Fusco, M.D., a New York dermatologist. Her go-to: Nutrafol Core for Women, which contains antioxidants, adaptogens, and botanicals. Day recommends that in tandem with supplements, patients apply a topical 5 percent minoxidil foam daily (available as Womens Rogaine). In clinical studies, 81 percent of women regrew hair up to 48 percent thicker, she says. The earlier you start, the betterits easier to preserve the hair you have than it is to regrow it. Another pro pick: an FDA-cleared at-home laser helmet like Theradome Pro worn two or three times a week. The light produces cellular energy to help induce growth. (All of these treatments require maintenance.) More aggressive treatments include PRP (platelet-rich plasma) injections for four to six months to stimulate dormant follicles and, in severe cases, a transplant.

If youre not ready to go silver, prepare for a committed relationship with your colorist. The average client comes in every four weeks, says Kyle White, a colorist at New Yorks Oscar Blandi salon. Coarse hair is more difficult to cover, but, paradoxically, dyeing hair can improve the texture. The chemicals make strands more pliable, explains White. Clients notice their gray roots getting wiry, and once we touch them up theyre more manageable. Highlights are an additional option to consider because they provide a flattering contrast between hair and skin. And because youre investing all that time coloring your hair, ensure lasting results by using a color-safe shampoo and conditioner, such as LOral Paris EverPure Repair & Defend Shampoo and Conditioner.

When hair shrinks in diameter and loses pigment, its structure also changes: Hair is both coarser and more fragile. According to Joe Martino, creative director of New Yorks Orlo Salon, the solution is hydration. People are afraid to weigh down thin hair with an oil, says Martino. Its actually the best thing for mature hair. Since the scalp produces less oil, conditioning strengthens hair and gives it shine. Use a deep-conditioning masklike Love Beauty and Planet 2 Minute Magic Masqueweekly, as well as argan oil, such as Moroccanoil Pure Argan Oil, to tame wiry strands. Work a few drops through dry hair. Pure argan oil wont weigh down hairand really does make it look younger.

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Best Anti-Aging Tips and Products for Skin and Hair - HarpersBAZAAR.com

Mansfield’s Daniel Maberry has returned to coaching during battle with cancer, but his stay on sideline will be brief – The Dallas Morning News

Mansfield football coach Daniel Maberry was forced to take an 11-month break from coaching games as he battled an incurable disease.

The last two weeks, Maberry was finally feeling well enough that he could pause his fight with cancer and coach his first two games of the season. His return to the sideline will be brief, however.

The 47-year-old Maberry said Tuesday night that he hopes to coach Friday when Mansfield (1-3, 0-1 District 7-6A) plays South Grand Prairie (2-2, 1-0) at 7:30 p.m. at the Gopher-Warrior Bowl in Grand Prairie. But that will be his last game of the season, as he prepares to begin eight weeks of treatment in early October, with the first two weeks spent in the hospital.

"I plan to be on the sideline [Friday], but it will depend on what I can do," he said.

Maberry coached last Friday after getting radiation treatment earlier in the day. "It zaps you," he said, but he handled the head coaching duties while interim coach Greg George returned to his role as offensive coordinator.

"It was awesome," said Maberry, who had to take a break from coaching last season after Mansfield's game against DeSoto on Oct. 12, 2018. "Having an opportunity to coach my kids and be excited with them. I had been away from it for too long."

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Maberry was diagnosed with Stage 4 lymphoma in January 2018, but in June of that year doctors told him that his disease was basically in remission, and had become "inactive." That wouldn't be the last time he would hear that, only to see the lymphoma return.

Three to four months later, Maberry's disease had morphed into an aggressive form of non-Hodgkin's lymphoma called diffuse large B-cell lymphoma. After undergoing chemotherapy, Maberry was told in March that he was clear of it, that it was back in remission.

Maberry had a stem cell transplant in April, only for doctors to detect a small spot on his rib cage in early August. He started radiation treatment last week, but he's not giving up and credits his family and the Mansfield community with helping him throughout the grueling ordeal.

"God has used a lot of people to pick me up," he said. "It has been a kick in the gut every single time. It has been incredibly hard, but I can't allow this to rob me of my joy. I feel like I am going to get better. My faith is strong."

Twitter: @DMNGregRiddle

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Mansfield's Daniel Maberry has returned to coaching during battle with cancer, but his stay on sideline will be brief - The Dallas Morning News

Eyes on the Prize: The CBC Fights Blindness During Sickle Cell Awareness Month – The Root

Blood is the jet fuel of the body. It helps you jump, run, breathe and move with ease through the world. So imagine what happens if that fuel isnt running smoothly through your body. Its clogging your system, straining every valve, organ and extremity as youre slowly starved for air. That sounds excruciatingly painful, and thats exactly what 1 in 365 African Americans deal with who suffer from sickle cell anemia.

September is Sickle Cell Awareness Month and its common throughout the month to see awareness raising articles about famous people living with sickle cell, like actor Larenz Tate (Power), T-Boz from TLC, former Giants running back Tiki Barber or even Howard University President Wayne Frederick. You seldom see stories about what actions are being taken by scientists and researchers to make sickle cell disease and the dozens of medical consequences that stem from it a thing of the past. Thats why Rep. Sanford Bishop (D-Ga.) and the Congressional Black Caucus have decided to do something about it.

The reason most peoples blood runs smoothly through their bodies is that red blood cells are round and smooth, which allows them to slip through blood vessels with ease. For those with sickle cell, red blood cells have hardened into a C shape, (thus the sickle name); they clog the bloodstream and choke off vital oxygen to organs, causing pain, organ failure and, in some cases, death.

When a child is diagnosed with sickle cellsometimes even toddlersdoctors often warn parents about the childs potential limitations and prescribe proper therapy and medication to make sure he or she lives a long and healthy life. Unfortunately, like many other areas of the American healthcare system, not enough attention is paid to a disease that primarily affects African Americans, and many of the other consequences of sickle cell get missed.

Sickle cell retinopathy is overlooked by most pediatricians but even some specialized doctors, says Morton Goldberg, the director emeritus of the Wilmer Eye Institute at Johns Hopkins University in Baltimore. Dr. Goldberg has the tone of a man who has been in the trenches for years and is finally seeing a turning point in the war. He has been working on sickle cell retinopathy for over 50 years and talks about how the disease, because it is most common in African Americans, is often overlooked even though the consequences are utterly dire and easily preventable.

For the layman, sickle cell retinopathy is when the diseased blood cells cause clogging in the blood vessels around the eye, which can lead to a host of other complications, the most serious being blindness. There is equipment out there, even training that can help doctors diagnose sickle cell retinopathy early to give parents and patients the tools they need, but that need usually goes unmet. Why?

Theres been insufficient funding for the last 30 to 40 years, says Dr. Goldberg, which is why hes on board to promote H.R. 2620, the Faster Treatments and Cures for Eye Diseases Act proposed by Bishop.For far too long, we have had federally funded research sitting on the shelf, waiting for private investors to put it into practice, Congressman Bishop said. When it comes to turning research into cures, we must seek new ways to tackle old problems. The Eye bonds created by the Faster Treatments and Cures for Eye Diseases Act will give health research the boost it needs to help Americans. These bonds will fund research that has the potential to deliver new treatments for a range of conditions, including macular degeneration, glaucoma, blindness caused by diabetes and sickle cell disease, and many others. And this is just the first step, if this pilot program is successful, a similar approach could be used to support groundbreaking research for other conditions such as cancer, Alzheimers and Parkinsons disease.

Money is, of course, one of the main reasons why research into preventing blindness caused by other diseases often doesnt go anywhere or doesnt go far enough, especially when those suffering are from underserved communities to begin with. On top of blindness caused by sickle cell, retinopathy from diabetes causes 17 percent of vision loss in African Americansand blindness caused by glaucoma is twice as likely (3.4 percent) in African Americans as it is in white Americans (1.7 percent).

A lot of this is about access to care, says Dr. Carlton Haywood, a professor of biomedical ethics at Johns Hopkins. The bill proposed by Rep. Bishop has particular resonance with Haywood since he actually has sickle cell and has spent much of his career focusing on the impact of care and access for blood-borne diseases. Haywood, who was also a former patient of Dr. Goldberg, points out that even when a doctor may advise a family to look into the possibility of retinopathy, without funding for even the diagnosis, preventive or corrective surgeries could be astronomical.

All too often, the press and regular voters talk about all the things that Congress doesnt do. In the process, we forget about the kind of day-to-day grind work that members of Congress do every day to help people not just in their districts but across the nation.. The Faster Treatment and Cures for Eye Diseases Act is the kind of thing that everyone says they want Congress to pass (who isnt against blindness?), but it currently sits in the Energy and Commerce Committee, waiting for a vote in committee so that it can be voted on by the entire House. This is the kind of bill America wants to see, and this bill, both figuratively and literally, can make that happen.

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Eyes on the Prize: The CBC Fights Blindness During Sickle Cell Awareness Month - The Root

What’s on TV Monday: The season premiere of ‘Bull’ on CBS – Los Angeles Times

SERIES

The Neighborhood Its been a year since Dave and Gemma (Max Greenfield, Beth Behrs) moved in, and now Dave wants to take a more active role in Calvins (Cedric the Entertainer) annual Yardecue event in the season premiere of the family comedy. 8 p.m. CBS

The Voice Gwen Stefani joins returning coaches Kelly Clarkson, John Legend and Blake Shelton on the first night of blind auditions in the season premiere. 8 p.m. NBC

Dancing With the Stars This new episode features the first elimination of the season. 8 p.m. ABC

9-1-1 What is expected to be a routine traffic stop uncovers a kidnapping in progress. Angela Bassett and Oliver Stark star in the season premiere with guest stars Tracie Thoms, Gavin McHugh, Bryan Safi and Christopher Cousins. 8 p.m. Fox

Country Music Will the Circle Be Unbroken? (1968-1972), the next installment of Ken Burns documentary series, chronicles the musical genre during the Vietnam war era. Kris Kristofferson, Bob Dylan and The Byrds go to Nashville to record. 8 p.m. KOCE and KPBS

Bob Hearts Abishola Billy Gardell stars as Bob, a Detroit businessman who lands in the hospital from the stress of running a family-owned compression-sock company. He starts to fall for Abishola (Folake Olowofoyeku), the Nigerian immigrant who is his cardiac nurse, and resolves to win her over. Christine Ebersole, Matt Jones and Maribeth Monroe (The Good Place) costar. 8:30 p.m. CBS

All Rise Simone Missick stars as a newly appointed judge who runs her court in her own unique way. Marg Helgenberger, Lindsay Mendez and Ruthie Ann Miles costar along with Wilson Bethel, Jessica Camacho and J. Alex Brinson. 9 p.m. CBS

Halloween Baking Championship John Henson kicks off the fifth season of this holiday-themed baking competition with a challenge for the eight bakers to create scary skeleton desserts. Carla Hall, Katie Lee and Zac Young are the judges. 9 p.m. Food Network

A Very Brady Renovation Steve and Leanne Ford team up with Christopher Knight and Eve Plumb to build out the kitchen and family room on the first floor. Also, the Brady backyard gets artificial turf. 9 p.m. HGTV

Prodigal Son This new crime drama stars Tom Payne (The Walking Dead) as a gifted criminal psychologist whose qualifications for helping the New York Police Department solve crimes include his father (Michael Sheen), a serial killer known as The Surgeon. Halston Sage, Bellamy Young (Scandal) and Lou Diamond Phillips also star. 9 p.m. Fox

Bull Distracted by his looming role as a new father, Bull (Michael Weatherly) lets his work at his jury consulting firm suffer, and Benny (Freddy Rodriguez), his top attorney, has quit in protest of some of Bulls recent and ill-advised romantic liaisons. Geneva Carr and Christopher Jackson also star. Yara Martinez and David Furr guest star in the season premiere. 10 p.m. CBS

Bluff City Law After the death of her mother, an attorney (Caitlin McGee) accepts an invitation from her estranged father (Jimmy Smits) to rejoin his prestigious Memphis law firm in this new legal drama. They try to reconnect as father and daughter while meshing their dramatically different courtroom styles. Scott Shepherd, Barry Sloane, Michael Luwoye, MaameYaa Boafo, Stony Blyden and Jayne Atkinson also star in this new drama. 10 p.m. NBC

The Good Doctor The third season of this medical drama opens the day after Shaun and Carlys (Freddie Highmore, Jasika Nicole) first date, which was, from his perspective, a disaster. 10 p.m. ABC

CBS This Morning Oprah Winfrey; Kevin Frazier. (N) 7 a.m. KCBS

Today (N) 7 a.m. KNBC

KTLA Morning News (N) 7 a.m. KTLA

Good Morning America (N) 7 a.m. KABC

Good Day L.A. Billy Bush (Extra Extra). Neurosurgeon Dr. Robert Louis; Elizabeth Wagmeister, Variety; Jerry Springer (Judge Jerry); Marcellas Reynolds. (N) 7 a.m. KTTV

Live With Kelly and Ryan John Goodman (The Conners); Robert Iger, Disney. (N) 9 a.m. KABC

The View Robert Iger, Disney. (N) 10 a.m. KABC

Rachael Ray Tom Payne (Prodigal Son). (N) 10 a.m. KTTV

The Wendy Williams Show (N) 11 a.m. KTTV

The Talk (N) 1 p.m. KCBS

The Dr. Oz Show A fertility clinics mistakes result in multiple women giving birth to other couples babies. (N) 1 p.m. KTTV

The Kelly Clarkson Show Trisha Yearwood; Erin Moriarty (The Boys); chef Keith Garrett. (N) 2 p.m. KNBC

Dr. Phil A private investigator says he has new information about the car crash in which Princess Diana died. (N) 3 p.m. KCBS

The Ellen DeGeneres Show Oprah Winfrey; Lil Nas X performs. (N) 3 p.m. KNBC

The Real Blac Chyna (The Real Blac Chyna); guest co-host Amanda Seales (book Small Doses). (N) 3 p.m. KTTV

The Doctors Employers pushing stem-cell treatments to workers; an Instagram body-slimming trend. (N) 3 p.m. KCOP

To the Contrary With Bonnie Erb Debate week. 6 p.m. KVCR

Amanpour and Company (N) 11 p.m. KCET; midnight KVCR; 1 a.m. KLCS

Conan Jeffrey Dean Morgan. (N) 11 p.m. TBS

The Tonight Show Starring Jimmy Fallon (Season premiere) Gwen Stefani; Ben Platt; Zac Brown Band performs. (N) 11:34 p.m. KNBC

The Late Show With Stephen Colbert Paul McCartney. (N) 11:35 p.m. KCBS

Jimmy Kimmel Live 11:35 p.m. KABC

The Late Late Show With James Corden Rob Corddry; Lake Bell; Anna Drezen. (N) 12:37 a.m. KCBS

Late Night With Seth Meyers Liza Koshy; Jade Bird performs. (N) 12:37 a.m. KNBC

Nightline (N) 12:37 a.m. KABC

A Little Late With Lilly Singh (N) 1:38 a.m. KNBC

NFL Football The Chicago Bears visit the Washington Redskins, 5 p.m. ESPN

NHL Preseason Hockey The Anaheim Ducks visit the Kings, 7:30 p.m. Fox Sports Net

For more sports on TV, see the Sports section.

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What's on TV Monday: The season premiere of 'Bull' on CBS - Los Angeles Times

Rheumatoid Arthritis Stem Cell Therapy Market Excessive Growth Opportunities Estimated to be Experienced 2018 to 2028 – Commerce Gazette

Rheumatoid arthritis stem cell therapy has been demonstrated to induce profound healing activity, halt arthritic conditions, and in many cases, reverse and regenerate joint tissue. Today, bone marrow transplant, adipose or fat-derived stem cells, and allogeneic mesenchymal stem cells (human umbilical cord tissue) are used for rheumatoid arthritis stem cell therapy. As the rheumatoid arthritis worsens, the body initiates autoimmune response and attacks the cells. Rheumatoid arthritis stem cell therapy is growing in popularity across hospitals, ambulatory surgical centers, and specialty clinics, as it increases the healing of joints and further treats the entire system that causes the joint pain and inflammation.

The stem cells with ability to stimulate regeneration, immune modulating capacity, and excellent anti-inflammatory activity can be screened and selected. In addition, abundant amount of mesenchymal stem cells can be obtained from umbilical cord tissue. These are some of the key factors favoring the development of rheumatoid arthritis stem cell therapy market. Government are heavily investing in healthcare sectors which is turn is expected to fuel growth of the rheumatoid arthritis stem cell therapy market. Growing research to find effective treatment for various autoimmune disorders will possibly create potential growth prospects of rheumatoid arthritis stem cell therapy market.

Rheumatoid arthritis is one of the many types of arthritis and is an autoimmune disorder. In patients with rheumatoid arthritis, the immune system attacks different parts of joints by generating cellular responses and antibodies to various tissues, including collagen, which leads to joint deterioration along with complications such as heart damage and pulmonary fibrosis. Rheumatoid arthritis affects 1% of the general population worldwide. Unfortunately, the available treatments cause adverse effects as they inhibit responses of the immune system in non-specific ways. Rheumatoid arthritis stem cell therapy is an alternative option as the therapy works to induce healing while regenerating healthy tissue. Rheumatoid arthritis stem cell therapy also has a modulating effect on the immune system, which helps in fighting diseases while turning off some of the pathological responses. Today, new treatments and advances in rheumatoid arthritis research are being studied. Rheumatoid arthritis stem cell therapy is being studied for its efficacy in improving complications in patients through the use of their own stem cells. These stem cell therapies may help patients who do not respond to typical drug treatment and want to reduce their reliance on medications or who are looking to try stem cell therapy before starting a drug treatment.

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Rheumatoid Arthritis Stem Cell Therapy Market: Drivers and Restraints

The growing prevalence and recurrence of rheumatoid arthritis is expected to be the major factor driving the growth of the rheumatoid arthritis stem cell therapy market over the forecast period. Although doctors do not know the exact cause of rheumatoid arthritis, but certain risk factors are observed to be associated with it. These risk factors include age (most common between the age of 40 and 60), family history, gender, environment (a toxic chemical in the environment can up the odds), obesity and smoking. Changes in lifestyle and eating habits are contributing to the growing prevalence of rheumatoid arthritis. Development and addition of new therapies is the other factor contributing to the growth of the global rheumatoid arthritis stem cell therapy market. For instance, Belgian company TiGenix announced a randomized phase II trial of its adipose derived stem cell product Cx611. The trial started in 2015 for patients who have active rheumatoid arthritis despite being treated with methotrexate and steroids.

Rheumatoid Arthritis Stem Cell Therapy Market: Segmentation

Tentatively, the global rheumatoid arthritis stem cell therapy market can be segmented on the basis of treatment type, application, end user and geography.

Based on treatment type, the global rheumatoid arthritis stem cell therapy market can be segmented into:

Based on application, the global rheumatoid arthritis stem cell therapy market can be segmented into:

Based on distribution channel, the global rheumatoid arthritis stem cell therapy market can be segmented into:

Based on geography, the global rheumatoid arthritis stem cell therapy market can be segmented into:

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Rheumatoid Arthritis Stem Cell Therapy Market: Overview

The global market for rheumatoid arthritis therapeutics is expected to witness moderate growth over the forecast period. Among the two treatment types, the allogeneic mesenchymal stem cell segment is expected to lead in the global rheumatoid arthritis stem cell therapy market over the forecast period. Hospitals are expected to contribute a considerable high share in the global rheumatoid arthritis stem cell therapy market as they are the most accessible channel.

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Rheumatoid Arthritis Stem Cell Therapy Market: Regional Outlook

Geographically, the global rheumatoid arthritis stem cell therapy market can be segmented into viz. North America, Latin America, Europe, Asia-Pacific excluding Japan (APEJ), Japan and the Middle East and Africa (MEA). North America is expected to be the dominant region in the global rheumatoid arthritis stem cell therapy market, owing to the presence of various key players. The rheumatoid arthritis stem cell therapy market in Asia Pacific excluding Japan is expected to grow at a significant CAGR due to the expansion of product offerings by key players. Europe is expected to have the second large share in the global rheumatoid arthritis stem cell therapy market throughout the forecast period.

Rheumatoid Arthritis Stem Cell Therapy Market: Key Players

The global market for rheumatoid arthritis stem cell therapy is highly fragmented. Examples of some of the key players operating in the global rheumatoid arthritis stem cell therapy market include Mesoblast Ltd., Roslin Cells, Regeneus Ltd, ReNeuron Group plc, International Stem Cell Corporation, TiGenix and others.

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Rheumatoid Arthritis Stem Cell Therapy Market Excessive Growth Opportunities Estimated to be Experienced 2018 to 2028 - Commerce Gazette

Forecasting the Future of Medicine – The Future of Things

Photo byChokniti KhongchumfromPexels

A forecast is taking an educated guess on how past patterns will shape the future. When forecasting the future of medicine, astounding innovations suggest the advent of an age of medical miracles.

In the future, we can expect new cancer treatments and the prevention of genetic diseases, and many other life-changing therapies. We can also expect that will create far less terror in patients because dentists will set aside their injections and drill for tooth cavities because they will know how to organically rebuild teeth.

Proton beam therapy. liquid biopsies and immunotherapy will save countless lives of patients diagnosed with cancer.

First, proton beam therapy will destroy tumors. This treatment delivers particles to cancerous tumors through a machine that uses a pencil beam scanning technology.

Next, liquid biopsies will replace invasive biopsies. Since early cancer detection improves a patients chances of recovery or remission, doctors rely on biopsies for faster, more reliable diagnoses. Now, medical researchers at the John Hopkins School of Medicine have developed a blood test that can screen for certain types of cancers by identifying specific DNA biomarkers and proteins.

Finally, cancer immunotherapy will use the bodys own immune system to heal cancer. This cancer treatment engineers a persons T-cells to target cancer cells, recognizing them by their biomarkers.

Traditional cancer treatments like chemotherapy and radiation therapy cause iatrogenic side effects like infertility, lymphedema, brain damage, nausea, diabetes, hemolytic anemia, or hair loss, but using the bodys own immune system causes no harm. Before they were engineered in the lab to become biological super soldiers, a patients T-cells would be overwhelmed by teeming cancer cells. They always lost the battle.

Research on these three cancer-fighting therapies still has a long way, but the results so far look promising.

Genetic traits pass through families in distinct patterns. A gene is a segment of deoxyribonucleic acid (DNA) that carries instructions on how specific proteins should function in cells. Packaged into chromosomes, genes reside in the nucleus of cells. Although this mechanism of passing down genes to offspring works flawlessly most of the time, on rare occasions parents can pass down copies of mutated genes. For instance, in a rare genetic disease called cat eye syndrome, a person inherits a genetic defect in chromosome 22. Since the gene is malfunctioning, not giving the bodys intelligence the right information on how a specific protein should function, a cascade of unusual symptoms appear, such as congenital heart defects, wide-set eyes, and abnormal ribs.

Modern medicine cannot cure genetic diseases because genetic changes are present in every cell of the body and influence many biological systems. So, the best doctors can do is to provide treatments that manage some symptoms. However, scientists have now discovered an unusual workaround idea: editing mutations in the genes of embryos. One day, gene editing technology may give scientists the ability to rewrite DNA to prevent the transmission of rare genetic diseases.

Tooth repair often involves drilling into a cavity to fill it. In the future, this routine practice may become obsolete. Researchers have found a drug that stimulates the growth of stem cells in teeth to create dentine, an essential tooth mineral that gets eroded when someone has a tooth decay. This drug called tideglusib is currently used for patients with Alzheimers. However, it has now been shown to organically rebuild dentine. The day is fast approaching when the idea of getting a cavity filling will be considered a rather barbaric way to repair teeth.

Although the future is always unpredictable, these medical discoveries suggest emerging trends in medicine that will transform healthcare as we know it. Many of the illnesses we consider incurable today may be ingeniously healed tomorrow.

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Forecasting the Future of Medicine - The Future of Things

‘My blood brother:’ Bone marrow donation started a friendship – Ottawa Citizen

Chris Smith donated bone marrow to Sue Vanvolkingburgh in 2004. They met for the first time in 2005 and have been good friends ever since.Handout photo

Sue Vanvolkingburgh met the man who saved her life for the first time more than a year after he did the saving.

This was in September 2005 in front of hundreds of people at a gala in at the Canadian War Museum in Ottawa.

It was literally the three-minute hug, recalls Chris Smith, the man who donated his bone marrow to a woman he had never met.

Now, 14 years later, the pair still consider themselves blood siblings. They meet as often as possible. Their families have reunited for trips to baseball games, amusement parks and Vanvolkingburghs 50th birthday party.

Because Smiths marrow now produces her blood cells, Vanvolkingburgh now has Smiths blood type.

I call him my blood brother, said Vanvolkingburgh, a CHEO nurse who wlil turn 56 this week. I have his DNA in my blood. Im a bit of a hybrid.

Just last week, Smith, now 61 and retired from a job as a Canada Post supervisor, reunited with Vanvolkingburgh in Ottawa for a hockey game, touristy activities around Parliament Hill and a golf tournament for the Bruce Denniston Bone Marrow Society, a charity that raises money to promote donor matches and is named after an RCMP member who was diagnosed with leukemia in 1987.

In 2003, Vanvolkingburgh was diagnosed with aplastic anemia, a blood disorder that occurs when the body stops producing enough new blood cells. The only option was a bone marrow transplant. She needed a sibling match or an anonymous donor. Doctors found her match on the donor registry.

Unknown to Vanvolkingburgh, her match had a story of his own. Smith, who lived in Barrie, Ont., had a niece who had been diagnosed with a form of leukemia. There were nine siblings in his family and they all signed up for the bone marrow registry. His niece was successfully treated without a transplant, but Smith thought there might be other people who might need his bone marrow.

In 2004, Smith received the call to ask if he was still interested in donating. I did what I had to (do) to give that person an opportunity, he said.

By the time Vanvolkingburgh was a candidate for transplant, she was transfusion-dependent. To prepare for the transplant, she was given high doses of chemotherapy and underwent full-body radiation. After the transplant, there was nothing to do but watch and wait in isolation. She was in hospital for 2 1/2 months.

At first, Vanvolkingburgh was told the donation would remain anonymous. Then she received a card through One Match (now Canadian Blood Services Stem Cell Registry) with all the identifying information blacked out. On the card, her donor said his family was praying for her.

I felt humbled and overwhelmed, she says now.

In 2005, Smith and Vanvolkingburgh both received a neutrally-phrased letter saying they could exchange information if they wanted. They agreed, and One Match sent them mailing addresses.

Vanvolkingburgh said she struggled over what to tell her donor. You say, Thank you, to the grocery clerk. I was having problems with even how to begin to say, Thank you.

Later that year, Smith and Vanvolkingburgh were asked if they were willing to meet for the first time. It happened at a gala at the Canadian War Museum in September in front of an audience that included members from the clinical team that treated Vanvolkingburgh.

Since 2016, Canadian Blood Services has had 410 requests for donors and recipients to exchange information, but had only 275 completed requests with contact information provided to both donor and recipient.

Its impossible to say how many donor recipient pairs have actually made contact, said Heidi Elmoazzen, director for stem cells at Canadian Blood Services. Because registries are international, it may be difficult for many people to meet face-to-face, she said. The Canadian registrys policy is to wait a year after a transplant to accept requests. It may be longer for other registries, and some dont allow that information to be exchanged.

For Vanvolkingburgh and Smith, meeting was the start of a friendship between two families. Both have three children and three grandchildren. They share sorrows and joys. Everyone in both families has registered for bone marrow donation.

No one of us knows what tragedy will strike a family member, Smith said.

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'My blood brother:' Bone marrow donation started a friendship - Ottawa Citizen

MGTA-456 Earns Regenerative Medicine Advanced Therapy Designation – Adrenoleukodystrophy News

TheU.S. Food and Drug Administration (FDA) has granted Magenta Therapeuticscell therapy MGTA-456 the Regenerative Medicine Advanced Therapy (RMAT) designation for treating inherited metabolic disorders, including cerebral adrenoleukodystrophy.

The RMAT designation is a program established to help expedite the development and approval of promising therapies. It isgiven to products that have preliminary clinical evidence of being able to treat, modify, or cure a serious or fatal disease, and potentially address unmet medical needs for that disease.

This RMAT designation was based on the encouraging clinical data we have presented thus far, and it is an important milestone that recognizes the transformative, life-saving potential of MGTA-456 for children suffering from inherited metabolic disorders, John Davis, MD, chief medical officer at Magenta Therapeutics, said in press release.

MGTA-456 is a stem cell-based therapy specifically,allogenic hematopoietic stem cell therapy (HSCT) designed to help stop the progression of inherited metabolic disorders. This is possible through the delivery of a high-dose of stem cells to help regenerate the patients immune system. The procedure requires patients to receive a transplant of healthy blood-forming cells, orhematopoietic stem cells (HSCs), from a genetically identical donor (allogenic), to replace their own diseased cells.

MGTA-456 is being developed as a treatment for multiple diseases.

The therapy is currently being evaluated by Magenta in a Phase 2 clinical trial (NCT03406962) in patients with various genetic metabolic disorders, including cerebral adrenoleukodystrophy (cALD), Hurler syndrome, metachromatic leukodystrophy, or globoid cell leukodystrophy. All participants are older than 6 months.

This Phase 2 clinical trial is being conducted at four U.S. medical centers: Cincinnati Childrens Hospital, Duke University, Emory University, and the University of Minnesota.

Previous results from the first five patients two of them with cALD who were followed for six months, showed a rapid and consistent benefit withMGTA-456 treatment that was not seen with other investigational therapies.

Patients with cALD, in particular, were found to have resolution of brain inflammation on magnetic resonance imaging (MRI) scans, as early as 28 days after the treatment.Additionally, patients had stable neurological function scores at six months post-treatment, suggesting that the progression of the disease was halted.The Loes score, which quantifies the severity of brain abnormalities and atrophy, also was stable at six months.

All five patients analyzed achieved the primary goal of neutrophil engraftment, in which levels of neutrophils (a type of immune cell) have reached an absolute count of 500 or more neutrophils per cubic millimeter of blood for three consecutive days. Of note, a robust neutrophil engraftment means that the transplant of the stem cells was succeeded.

Following the success of this trial, Magenta expects to present further data before the end of 2019.

We look forward to collaborating closely with the FDA as we seek to rapidly advance MGTA-456 through the ongoing Phase 2 study, and into potential pivotal studies in 2020, Davis said.

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MGTA-456 Earns Regenerative Medicine Advanced Therapy Designation - Adrenoleukodystrophy News

Equine Tendon Injuries: Reducing the Strain – TheHorse.com

Equine athletes can sustain a variety of orthopedic injuries, but tendonswhich attach muscle to boneare especially prone to strain and damage. Superficial digital flexor tendon injuries remain a frequent and frustrating cause of morbidity (disease) in athletic horses, having been noted as the primary reason for retirement of Thoroughbred racehorses over a 12-year period (Lam 2007). The initial tendon injury leads to not only pain and an inability to work but also re-injury rates as high as 82% (Genovese 1997). Subsequently, tendon healing strategies and optimized rehabilitation have become big-ticket items for the equine sports medicine community.What Do I Do if I Suspect an Injury?

The classic signs of tendon injury in horses include general symptoms of inflammation: heat, pain, and swelling. Depending on where the injury is located, you might not detect obvious swelling or heat (for example, deep digital flexor tendon injuries within the hoof capsule dont cause overt swelling and are best diagnosed with MRI). Tendon injuries of the mid-metacarpal (or cannon bone) region, however, often cause noticeable swelling, heat, and pain upon palpation. Initially, tendon-associated lameness can be severe, depending on the extent of the injury and its severity and chronicity.

If you suspect your horse has a tendon or soft-tissue injury, connect with your veterinarian immediately to get an appropriate diagnosis and begin therapy. Most commonly, a complete musculoskeletal and lameness evaluation will help the veterinarian determine which soft tissue structures are involved. Your vet might recommend an ultrasound evaluation as a first-line imaging tool to assess tendinous tissue, but MRI evaluation might also be indicated in some cases to further characterize the injury. Once your veterinarian has made a diagnosis, you can discuss treatment options to get your horse on the road to recovery.

The bodys intrinsic tendon repair process involves three continuous phases. The initial inflammatory phase typically occurs during the first one to three days following injury. Initial triage strategies usually consist of decreasing inflammation using cryotherapy (icing), rest, anti-inflammatories, and supportive care. The subsequent phases of repair (two to 28 days) and remodeling (60 days onward) are characterized by tissue reorganization and scar tissue formation. Once you and your veterinarian have gotten the initial pain and inflammation under control, you can aim rehabilitation strategies toward encouraging organized scar tissue formation that more closely resembles the tendons uninjured architecture.

Several treatment options are available for tendon injuries, yet no singular one-size-fits-all therapy currently exists. Researchers have described significant success using mesenchymal stem cells to treat tendon injuries in racehorses, with the most notable statistic being a significantly reduced re-injury rate. Despite the exciting research around biologic treatments such as these, controlled exercise and physical therapy remain the most important cornerstones of tendon healing.

Eccentric loading exercises have been shown to be particularly effective. These involve lengthening the muscle or tendon fibers while theyre load-bearing. Take, for example, the down phase of a biceps curl or a heel raise in humans. While the exact mechanism behind its therapeutic effect remains unknown, researchers believe this controlled mechanical stimulation helps the bodys scar tissue become more organized and functional.

Horses most commonly perform eccentric loading through assisted physical therapy exercises such as the withers pull (applying gentle lateral pressure to the side of the withers until the horse shifts his weight subtly toward your pull; hold that stretch for 3-5 seconds).

Similarly, controlled forelimb loading can help strengthen the soft tissues of the entire limb, including the supportive musculature of the shoulder, elbow, carpus (knee), and digit. Other eccentric physical therapy aids include surface changes, ground pole work, backing exercises, and modifications of the withers-pull exercise. Your veterinarian can prescribe specific therapy recommendations.

In summary, stem cell and physical therapy represent promising strategies for tendon repair. Recognizing the clinical signs, contacting your veterinarian, and getting appropriate treatment and rehabilitation plans in place will ultimately lead to the fastest recovery.

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Equine Tendon Injuries: Reducing the Strain - TheHorse.com

Bader Philanthropies to redevelop King Drive building into cafe and wellness center – BizTimes – Milwaukee Business News

Bader Philanthropies, Inc. plans to redevelop a vacant two-story building located across from its headquarters on Martin Luther King Drive into a cafe and wellness center.

The renovated building, located 3338 N. Dr. Martin Luther King, Jr. Drive in Milwaukees Harambee neighborhood, will be occupied by Sams Place eatery and cafe and Shalem Healing, Inc., a nonprofit medical clinic.

The new center will combine two properties, including an existing 1910 building, formerly occupied by Churches of the First Born a Rock Foundation Inc., and a recently demolished building at 3356 N. Dr. Martin Luther King Drive.The project will involve renovating the existing building and adding about 3,000 square feet, for a total of about 10,000 square feet.

The total project, including the building purchase and construction, is expected to cost $4.6 million. The new center is scheduled to open in spring 2020.

Bader Philanthropies moved from its former location in the Historic Third Ward to a formerly vacant building at 3300 N. Martin Luther King Jr. Drive in July 2018.

Bader Philanthropies moved to Harambee to deepen our commitment to Milwaukee, said Daniel Bader, president and chief executive officer of Bader Philanthropies. We wanted to be in a place where we could truly live our mission by putting down roots and embedding ourselves in a neighborhood. Harambee residents are giving a voice to ideas that have the potential to enhance the quality of life, the health and wellbeing of our neighbors. Sams Place and Shalem Healing are examples of what our neighbors would like to see present in their neighborhood.

Shalem Healing, currently located at 800 E. Locust St. in the Riverwest neighborhood, offers integrated medical and holistic care on a sliding scale based on patients income. It serves about 3,000 annually .

Shalem Healings commitment to holistic wellness, especially for people living in the underserved areas of the city, is the core of what we do, said Dr. Robert Fox, founder of Shalem Healing. It is simple we want to make holistic care such as herbal medicine, acupuncture, food as medicine, stem cell treatment, nutraceuticals, and proper education on seemingly chronic diseases as accessible to the residents living in Harambee and many others who will travel from around Milwaukee.

Sams Place will be a jazz-themed eatery and cafe, offering coffee through its roasting division, Abyssinia Coffee Roasters. It will be the second location for operator CITY.NET Jazz Caf. Its current location is in downtown at 306 E. Wisconsin Ave.

Sams Place is all about community, said Sam Belton, owner of Sams Place. People from all walks of life can gather here, meet a friend or neighbor, and connect for a meeting in a great eatery while experiencing the sounds of classic jazz. Patrons can also enjoy freshly roasted coffee on site and expect live performances from local and national artists. Our roots are deep in Milwaukee and we are dedicated to rebuilding our community.

Sams Place will occupy the first floor and Shalem Healing will occupy the second floor.

Bader has retained JCP Construction, LLC as the general contractor and American Design, Inc. as the architect for the project.

We are excited to have JCP Construction build what will be an extraordinary community resource for the neighborhood in which they grew up, said Franklin Cumberbatch, vice president for engagement of Bader Philanthropies. And, American Design will give this historic building a second life.

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Bader Philanthropies to redevelop King Drive building into cafe and wellness center - BizTimes - Milwaukee Business News