A Doctor Plumbs The Depths Of Ivan Doig’s Illness And Asks: ‘Did He Have An Epiphany?’ – Mountain Journal

I grew up in Ohio and met my first real Westerner at age 27. Kate was from Durango, Colorado and lived next door to me for two months during a rural primary care rotation in medical school. They rolled up the sidewalks at night in Twin Falls, Idaho and so we had plenty of time to talk. Books always figured prominently in the conversation and she recommended her favorite book about the West

Reading that first iconic chapter, Time Spent, led to a 25-year Doig odyssey that eventually landed me in a Montana State University archive reading the final draft of that same chapter, marked up with Ivans own red pen.

It begins, That start of memorys gather: June 27, 1945. I have become 6 years old, my mothers life has drained out at 31 years. And in the first grey daylight, dully heading our horses around from that cabin of the past, my father and I rein away toward all that would come next.

The Doig archive at Montana State is a treasure trove for fans. Its extensively indexed and entirely on line and filled with pictures, original manuscripts and the collection of 3 x 5 and 5 x 8 cards on which Doig kept quotes and observations from his extensive research travels in Montana.

Ivan kept box after box of these cards, many of them with only a single type written sentence, sometimes annotated in longhand. He shuffled and reshuffled these bits of memory assembling them into temporary collections as material to flesh out a particular character or story line and then returned them to their boxes only to be reshuffled and reassembled for the next novel.

In summer 2019, Carol Doig met with a group of visitors and discussed her husband's journey in his last years. Joining them was her close friend, Betty Mayfield, who helped assemble Doig's edited manuscripts, diaries, correspondence and other documents that today are part of the MSU Doig collection. Those joining Carol in her living are, left to right, Betty Mayfield, Dr. Rob Patrick, Justin Shanks a post-doctoral fellow working on the Doig material to make it digitally accessible, and writer Todd Wilkinson of Mountain Journal. Photo by Kenning Arlitsch, dean of MSU Libraries

Sometimes this shuffling was frozen into a more permanent form when he collected them into 2-to-3 page novellas with titles like Scotchisms and Curses.Most assumptions arent conscious until they are shattered. Without realizing it, I had cast my favorite writer in his own movie that ran only in my head.

He woke up in the morning, hunted big game, slept with the world's most beautiful women, cavorted at the Algonquin round table, drank his weight in scotch and then, late at night, great work flowed forth from his pen in a tortured and inspired torrent. He threw himself down exhausted, only to arise and repeat the performance with the dawn. The truth that emerged from touching the physical remnants of his process was far different.

Ivan Doig was . . . a nerd . . .just like me. I clipped articles and collected them in folders, wrote down random thoughts and observations on cards, restacked, hoarded and recombined information. My stories were just about thrombocytopenia and clonal proliferation instead of resilient ranchers scraping out an existence under the Big Sky.

The champion of the lariat proletariat was a closet geek. How disappointing.But my biggest disappointment was yet to come.The archive contained an odd and alluring folder title medical journey that was irresistible to me as a physician. I hadnt realized that Ivan suffered from multiple myeloma for the last eight years of his life and had written four books after being diagnosed with a terminal disease.

Myeloma is a strange form of cancer as cancers go, it is both painstakingly slow to progress and inexorably fatal. Patients rack up complications from the treatment, not because treatment is so toxic, but because they live long enough to suffer from the cure as well as the disease.

The core of the pathology is something called a plasma cell which under normal circumstances produces the antibodies that help fight off invading viruses and bacteria. In myeloma, a single plasma cell mutates and grows uncontrollably crowding out everything else in a patients bone marrow and gumming up their organs with immunoglobulin. The mutant cells eventually cant be contained inside the bone marrow and invade the surrounding solid bone causing painful fractures in the spine and long bones of the skeleton.

As if that was not bad enough, the core of chemotherapy is high dose steroids, usually dexamethasone or prednisone. Steroids are the poster child for double edged swords in medicine. They are simultaneously incredibly useful for suppressing the immune system in autoimmune diseases, cancer and anything that involves inflammation, while at the same time having the most broad ranging side effect profile of almost any medication.

It was a love for wildlands in the West that led Rob Patrick, at right, down the trail of Ivan Doig's books and when he had an opportunity to dive deeper into Doig's final years he jumped at the chance. Another thing that brought him to Bozeman and Greater Yellowstone is his close friendship with Kenning Arlitsch, Dean of MSU Libraries. Here they are on an autumn trip into the Yellowstone backcountry.

Probably the most serious side effects for myeloma patients are immunosuppression leading to increased risk for infection, a softening of the bones accelerating the tendency of the disease to cause fractures and emotional lability. The last of these sounds trivial, but isnt.

My first patient who suffered from this particular side effect literally started a sentence laughing and ended it crying. The cognitive effects can be especially debilitating, because at its peak, the drug lulls one into a false sense of security. It can make patients feel super human and I had one multiple sclerosis patient tell me it was the most powerful antidepressant she had ever taken and she almost looked forward to her next flare so she could get it again. However, on the way up and the way down it can cause confusion and a loss of emotional control that is profoundly disturbing, especially to someone who depends on their brain to make a living. Truly a blessing and a curse of modern medicine.

One of my biggest losses of innocence after medical school was realizing that professors had pulled the wool over my eyes concerning one of the fundamental diagnostic tools in medicinethe patient history. During the pre-clinical years you seldom get to talk to an actual patient and instead hone your skills using case presentations which I later came to understand were carefully curated stories masquerading as actual patients in which the non-salient details were conveniently expunged and the salient ones amplified for teaching purposes.

My teachers smugly told me, If you dont know whats wrong by the time you finish taking the history, take the history again." This illusion is perpetuated during third year clerkships when cases are cherry picked for medical students so as not to dispel the myth. The gloves come off during internship when it is too late to turn back and you realize that most patients have a hard time telling you how they feel no matter how many creative ways you come up with to ask the same question. Its not their fault, they usually just have never felt like this before and dont have the words to describe it.

When you add intoxication, mental illness, dementia, etc. to the mix, taking a history often becomes an exercise in communication breakdown and frustration. So imagine my joy at finding a history written by a professional communicator whose livelihood depended on his ability to observe the world and record it. It was like winning the internal medicine lottery.

Doig observed of myeloma: The waiting room of hell, furnished with side effects.

Of those side effects, he observed, The dex makes me longitudinal - - concentrated on a single line of endeavor at a time, no latitude to speak of and I would go to blow my nose and find there was not a handkerchief within 50 of me. Pill bottle caps leapt for the floor. My ordinary thought process resembles a homesteader digging out a stump, when loaded with dex I plodded right past nuances of life in temporary fixations on getting to my desk and writing things down. Which, amazingly, produced pages of a novel faster than when I wasnt taking the stuff. Dex gave me a mental pop, off-the-chart energy upstairs while it played games with the rest of me. Writing proved to be therapy for therapy.

On the topic of mortality, he explained in a written passage, I am now in remission, that terra incognita but better than being off the map(oblivion). He would add, I have not come out of this as any cheerleader for Nietzche: thera are countless preferable ways to strengthen in life without having something trying to kill you.

Facing the reality, he noted, Invariably fatal. Damn. But then, so is life. Its probably not polite to laugh out loud at the writings of a dying man, but I couldnt help myself and I also couldnt help wondering what a pleasure it would have been to take care of him. There was plenty of correspondence in the archive between Ivan and his doctors, but the most striking examples would probably have been overlooked by the uninitiated. The age of electronic medical records and e-mail allow patients unprecedented access to providers.

Like most technology, this chart messaging is both a blessing and a curse. The blessing is that it doesnt take three phone calls to catch a patient at home and tell them about their lab results.

The curse is the dozens of chart messages to return at the end of a busy day. Consequently, as Doig chronicled, brevity is the rule: Everything normal on your labs today, see you in 6 months."

Doig, when in his prime, trying to instill the lessons of history into his work. Here he absorbs the vibe in an abandoned farm house where heart-felt dreams rose, fell part like a heartache and drifted away. Photo by Carol Doig, courtesy MSU Library Doig Archives

The messages from Ivans providers went on for paragraphs, like post cards from your grandmother, and often came close to open displays of affection. All patients are equal, but some are more equal than others.

My day in the Doig archive was followed by an evening at the annual trout lecture hosted by the MSU library and I happened to find the only other Doig nerd who had spent any time with the medical journey files. Todd Wilkinson, the editor of Mountain Journal, shared my fascination with this little known part of Ivan Doigs life and suggested we pursue an event centered around his medical journey.

I couldnt imagine who else would show up to hear about such a niche topic, but didnt want to spoil the glow of our mutual fandom and encouraged him to pursue it. Three months later I found myself sitting in Carol Doigs living room in Seattle.This would be a good time to disclose that I am not a casual Doig fan. Im not a religious person, but I have made two literary pilgrimages in my life. The first was to Arches National Park to find the location of Edward Abbeys trailer from Desert Solitaire and the second was to White Sulfur Springs, Montana to see the place that had figured so prominently in Doig'sThis House of Sky.

Something still haunted me about the archives. Aside from the few pithy quotes above, there wasnt much mention of how Ivan faced his own mortality. How does an author get up every day and write four more novels when he knows hes dying? More importantly, why does he do it?

My practice over the last 20 years was working as a hospitalist. All of my patients were sick enough to be in the hospital and these days you have to be pretty sick to make it through those doors. I had seen hundreds of patients die and typically had end of life conversations with patients and families several times a week. Indeed, I had been on a personal crusade in the last few years to get doctors to talk with their terminally ill patients about their goals for the end of life and had coached other providers about how to do it.

So here was my chance to salvage something of my shattered romantic ideal about writers. Ivan must have had some big epiphany, I thought, that just wasnt there in his writing and my task was to extract it from his widow. I was as if a literary anthropologist on a mission.

It led to having a wonderful day in Seattle, sunny and warm; the Doig living room had a commanding view of Puget Sound. The house was spare and elegant and warm and inviting all at the same time and I got to see Ivans personal desk with his typewriter and his book collection.

Carol was charming and intelligent and well educated and everything you would expect from the spouse of your literary hero. Todd Wilkinson was there and Kenning Arlitsch, Dean of Libraries at MSU, too, and the person responsible for securing the Doig archive. Our conversation flowed easily.

Todd had a flurry of journalistic questions for Carol about Ivan and his writing. I was the final interviewer and my experience told me that it was almost always the wife that was the keeper of the medical history. So I started with some easy logistical questions.

Doig's desk, where he completed five books in eight years, battling through pain, the effects of medicines and a bone marrow transplant. All this and yet critics say these final works contain passages that are among the most incisive and moving of his four-decade long career. Photo by Todd Wilkinson

No, she did not go to all of his medical appointments with him and she didnt even know about the folder where he had kept all of the materials about his illness until after his death. There goes my first assumption.

We walked through the chronology of his illness, his initial diagnosis, the stem cell transplant, chemotherapy, remission, relapse, second line chemotherapy. What was daily life like? How did they deal with telling friends and family since he was not obviously ill until the end? How long was he on hospice? What was it like at the end? I probed, I rephrased, I asked the same question a different way. But there was no profound epiphany.

What she described instead was a guy who got up every day, made breakfast, went to his study and pounded out his words for the day. If he finished a novel on Friday, he started the next on Monday. A literary proletarian if there ever was one.

I have watched plenty of people die in my career, some face it with grace and dignity and resolve and some fight it and raise their fist against the sky until the last breath. What separated those who faced their end well from those who didnt?

Regret. Regret for things they hadnt done or relationships that had soured, but it boiled down to not living life the way they wanted to. My epiphany was that there was no epiphany. Epiphanies are extraneous when you are already living your best life. Ivan Doig was a wonderful writer, husband, friend, and colleague. If it isnt broken, dont fix it.

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A Doctor Plumbs The Depths Of Ivan Doig's Illness And Asks: 'Did He Have An Epiphany?' - Mountain Journal

Campaign to save five-year-old cancer sufferer has become one of the fastest online charity appeals EVER – The Sun

A CAMPAIGN to save a five year old cancer sufferer has become one of the fastest online charity appeals after reaching its 500,000 target in just three weeks.

The parents of Oscar Saxelby-Lee are gobsmacked to have reached the huge amount to fund the emergency life saving treatment abroad in under a month.

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Thousands have pledged the cash meaning he will now fly to Singapore to undergo potentially life-saving CAR-T cell therapy and a second bone marrow transplant in a bid to save his life.

Oscars battle has always drawn huge support and in March almost 5,000 people queued in the rain to find a stem cell donor to cure Oscar, from Worcester.

But despite finding a match, doctors discovered the rare T-cell acute lymphoblastic leukaemia had returned so Oscars parents launched the new appeal in September.

Olivia, 26, and Jamie, 23, have now thanked kindhearted givers who organised events from sponsored bike rides to non-uniform days to raise the incredible sum.

In a statement, the pair said: We are absolutely gobsmacked with the amount of humbling support we have received since the word go.

Over the last three weeks, we have watched the people of Worcestershire and beyond work together to raise this seemingly impossible amount of money.

It has been heart-warming to see schools, businesses, individuals and even children giving all they can.

We would like to thank you from the bottom of our hearts - you are truly amazing.

Doctors at Birmingham Childrens Hospital, where Oscar has been treated since last December, say he has only a short window in which he will be strong enough to travel.

But Oscars parents have urged people to carry on supporting them, saying they need help more than ever.

They added: Now we need to make sure that we have contingency funds available should Oscar need more care or have a more complicated recovery whilst there.

As we all know, this journey hasnt gone smoothly so we must be prepared for any additional hurdles.

As you will have seen from Oscars Facebook page, Oscar has needed to receive more treatment and have further tests done whilst we have been fundraising to keep his leukaemia at bay.

Now we have the difficult bit, the waiting.

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The initial funds are ready. Oscars medical team now need to wait for the results of his further tests, which determine the next steps.

When the best treatment plan for Oscar is confirmed by his medical team, having this funding will allow us to move very quickly.

Thank you so much to the people of Worcestershire and beyond for making this possible and once again doing everything in their power to help save our boy.

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Campaign to save five-year-old cancer sufferer has become one of the fastest online charity appeals EVER - The Sun

Six people with links to UCLH listed among most influential people in London – University College London Hospitals

The Progress 1000 is compiled every year. The theme of this years list is the future and technology, and embraces whole new sectors including augmented and virtual reality and cyber security, as well as a wide range of activists challenging inequality and helping the environment.

Dr Prasanna Sooriakumaran, a consultant prostate cancer surgeon at UCLH, was included for his pioneering robotic surgery. He is investigating new techniques to spare men with prostate cancer the potentially debilitating effects of surgery. Early trials show that his new technique has drastically reduced recovery time for up to 94 per cent of patients.

Prasanna said: It is a great honour to top the list of Londons most influential doctors in the Progress 1000 after having also made the list last year. This is a testament to the wonderful staff at UCLH, who provide world class care to men with prostate cancer.

Professor Bryan Williams is director of one of the UKs leading NIHR Biomedical Research Centres at UCLH, director of research at UCLH and Chair of Medicine at UCL. He is a clinician at UCLH and is recognised as one of the worlds leading authorities on high blood pressure.

He said: It is good to see recognition of the influence that staff at UCLH have in driving forward medical research and innovation in London and beyond.

Professor Charles Swanton, UCLs professor of personalised cancer medicine with a lab at UCL Cancer Institute and the Francis Crick Institute in Kings Cross, a consultant at UCLH and chief clinician at Cancer Research UK, is leading pioneering research on lung cancer. Professor Swanton studies how cancers evolve in the body to spread and become resistant to therapy. He is also researching ways to treat tumours more effectively.

Charlie said: This is a great testament to the hospital, university, Crick and CRUK and the team for making TRACERx possible.

Professor Tariq Enver, director at UCL Cancer Institute and professor of stem cell biology at UCL, leads a grand coalition in the war on cancer by encouraging closer working relations between UCL, Kings College London, Queen Mary University of London and the Francis Crick Institute, creating a centre of excellence for biotherapeutics.

Tariq said: It is fantastic that the vital work being done by the team in London - which has the potential to transform cancer treatment in the long run is being recognised and encouraged. Being nominated is a massive boost for all of us who have worked so hard to reach this point.

Professor Ravi Gupta, until recently an infectious diseases clinician at UCLHs Hospital for Tropical Diseases, studies the evolution and spread of HIV drug resistance globally. He, along with colleagues at Imperial College London, recently published a report on how a patient with HIV and lymphoma is now free from both conditions after an allogeneic stem cell transplant using cells from a donor lacking a critical receptor protein for HIV infection, CCR5. This work has rejuvenated the field of HIV gene therapy.

He said: It has been humbling to work at UCLH alongside such dedicated staff, both clinical and academic. I hope that recognition of the London Patient HIV cure in the Progress 1000 list will serve as an inspiration in London and beyond in the fight against HIV/AIDS.

Professor Chris Whitty, the chief medical officer for England and a UCLH physician, was included on the list for his work which focuses on the diagnosis and management of infectious diseases in children and adults.

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Six people with links to UCLH listed among most influential people in London - University College London Hospitals

Injection therapy has many faces | News, Sports, Jobs – Marquette Mining Journal

You wake up one morning to find that slight twinge in your hip has become significantly painful. Youve tried icing and ibuprofen but the pain is now severe and demands medical attention. What are you expecting the doctor to do?

As a weekend warrior, you expect some aches and pains following your regular game but that twisted ankle you experienced last weekend continues to hurt with every step. Once again, the typical home treatments, the familiar rest-ice-compression-elevation, have helped, but not enough. Greater expertise is needed.

The arthritic knee, damaged playing college sports, has been bearable for years, but that joint has become progressively more symptomatic over recent months. What are the options? Some pain relief is desired.

These are all common scenarios. A frequent answer to these question is an injection. Many physicians first recommendation for various problems will be an injection. But what exactly is being administered? Most people are aware of a few of the options, yet a plethora of substances can be administered via injection. Injection therapy is a technique practiced for many years and continues to be utilized as a safe, easily performed procedure in an office or out-patient setting.

Specifically, an injection is the act of putting a liquid, especially a drug, into a persons body using a needle and syringe. This is a technique for delivering drugs without significant quantities of the drug spreading throughout the body. Intra-articular injections, those performed into a joint, have a number of physiologic and practical advantages over systemic medications (such as those taken by mouth), including safety.

Many fear injections. Certainly, the pain produced can occasionally be considerable but, more often, is minimal to mild. Others have allowed hearsay and rumor to rule their decision making, claiming they shouldnt have any injections because theyre going to do more harm than good. It is true sometimes the relief is temporary, but if you dont want to have surgery, an injection is an approach for musculoskeletal conditions that should be attempted. It may only give you a few months of pain relief, but it is usually worth trying.

As anyone who has had more than one injection can attest, the symptoms produced by the procedure itself can vary greatly. When larger structures are injected, the procedure tends to be more painful. Yet, there are a variety of methods to reduce the discomfort. As you would expect, technique is a critical factor. Pushing the liquid in faster, although shortening the duration of the process, is more uncomfortable. Thus, patience on the part of the health care provider is beneficial.

Buffering the solution is helpful when the solution is acidic, as is often the case when local anesthetics are used. Understandably, a smaller needle will produce less discomfort, although some medications will not get through certain sized needles. Additionally, the use of an ethyl chloride or cold spray numbs the skin for an instant but greatly reduces the initial pain of penetration.

Injection therapy can be used to achieve many different goals, other than just pain relief. The administration of a local anesthetic, a medication which temporarily produces a sensory blockade, can be used for diagnostic purposes. If some particular body part is injected with an anesthetic, and the pain previously experienced is gone while the numbing agent is active, then we can surmise that structure is causing the pain.

Clearly, the benefits of an injection will depend largely on what is injected. Without question, the most commonly utilized medication is some type of corticosteroid, commonly referred to as cortisone, although that particular medicine is no longer in common use. Corticosteroids are not harmful when used appropriately, and have many different uses. Corticosteroid injections can be therapeutic and diagnostic. They reduce inflammation by inhibiting the production of a number of inflammatory substances. But because they can cause some thinning of tissue, they can be put into a cyst or scar tissue to reduce its mass.

Injections directly into an arthritic joint avoid conventional barriers to joint entry. Intra-articular injections are a minimally invasive procedure and can be performed easily in an outpatient setting, with a short recovery time. Again, there is a drastically lower risk of side effects or systemic toxicity due to this delivery method. Intra-articular corticosteroids are approved by the FDA, although concerns remain regarding the duration of its effects, and their safety profile. And if the situation leading to inflammation is not addressed, predictably, the relief of the steroid injection will be transient.

All medicines have some side effects, including steroids. When used unwisely, what was once a benefit can be a complication. Common side effects are a loss of skin fat, discoloration of the skin, and increased blood sugars. This latter effect is of particular concern in the diabetic population. Uncommon side effects, more likely when used inappropriately, are tendon ruptures or ligament tears.

Patients may be disappointed when they are told the injection recommended may be helpful for only a short time. For each pathology injected, the duration of relief can vary greatly. There are no guarantees with any medical procedure, and this includes injection therapies. The possibility it can provide relief and make some condition better seems a realistic goal, as opposed to trying to give a patient a specific timeline.

Over the last few decades there has been tremendous research into new therapies, with great interest in regenerative medicine. The basic concept is to find healthy ways to improve the bodys healing processes. Some of these newer techniques involve an injection. Some examples include PRP injections (platelet-rich plasma), stem cell therapies, and amniotic membrane injection. Benefits of regenerative medicine techniques include an improved safety profile and, maybe most important, the direct targeting of the biochemistry of osteoarthritis. An increase in movement may be seen, as well as improved muscle strength. They seem to be useful in treating repetitive stress injuries that havent healed properly or completely. Maybe most consequential is the reduction of pain levels. The hope is these novel methods may allow some to avoid surgery and can even lead to healing.

One concern with these new technologies is the lack of large scale clinical trials to back up these claims. Long-term clinical studies are needed to increase the evidence available about them, and so earn consideration in treatment frameworks. Until these are performed, there remains an element of uncertainty with these methods.

The regenerative medicine technique in longest use is prolotherapy, in which a highly concentrated glucose solution is injected into a tendon or ligament. This seems to jump-start the healing process, with the resulting inflammation being a natural and integral component of healing, as with platelet rich plasma injection. When performed into a damaged part, these injections can stimulate repair.

Botox injections are a completely different type of injectable therapy. This substance blocks certain chemical signals from nerves, especially those causing muscles to contract. Some common uses are to relax facial muscles (those causing wrinkles) or muscle spasms. Botox injections may also help prevent chronic migraines.

Getting a therapeutic injection can be a scary process and, occasionally, a painful one. Still, there are ways to reduce this. As with any treatment, these methods can be misused. And, once again, there are no guarantees in health care. But the benefits can be significant. Dont make assumptions: steroids can lead to healing, depending on the situation, and can significantly reduce pain. Dont let fear rule your decision-making process. Consider carefully all the options your health care team recommends. An injection may be your most effective path to relief.

Editors note: Dr. Conway McLean is a physician practicing foot and ankle medicine in the Upper Peninsula, with a move of his Marquette office to the downtown area. McLean has lectured internationally on wound care and surgery, being double board certified in surgery, and also in wound care. He has a sub-specialty in foot-ankle orthotics. Dr. McLean welcomes questions or comments atdrcmclean@outlook.com.

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Injection therapy has many faces | News, Sports, Jobs - Marquette Mining Journal

Michelle Wie exclusive interview: How golf’s great prodigy grew up – The Telegraph

But a long list of injuries: to neck, back, knee, hip and ankle, has curtailed that prodigious talent, so much so that she is able to bond with Tiger Woods over the travails of the treatment table.

Ive seen Tiger a couple of times [since her time out], Wie says. Its pretty funny that every time we lift off with, Hows your neck, hows your back? and hes like, Hows your this, hows your that? It takes about 10 minutes of checking off the injuries before we talk normally.

Its comforting talking to other athletes going through the same things. Sport can be harsh, but other stories can hit home and normalise it. It can give you a boost of energy to go again.

That does involve waiting until her wrist has healed. It is an injury which was plagued her since she fractured her right hand in a car accident two years ago. Wie is arthritic in both wrists and has just finished the latest round of platelet-rich plasma (PRP) injections to accelerate the healing of her injured ligaments. Her daily routine has become one of treatment, icing, recovery, therapy and repeat.

The break has provided a time for reflection, especially as she nears a milestone birthday. The twenties are hard, Wie says. They are too hyped. I think the twenties are the years you figure things out and Im excited about being in my thirties. Theres still so much more I want to accomplish.

With a degree in communications obtained from Stanford University, a career in TV when she hangs up the clubs looks the most likely option. Her commentary debut for the Golf Channel at the Solheim Cup was unsurprisingly assured.

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Michelle Wie exclusive interview: How golf's great prodigy grew up - The Telegraph

Cell Expansion Market is expected to rise at a remarkable CAGR during the Forecast Period 2016 2024 – Space Market Research

Global Cell Expansion Market: Overview

This report on the global cell expansion market analyzes the current and future prospects of the market. The report comprises an elaborate executive summary, including a market snapshot that provides overall information of various segments and sub-segments.

The research is a combination of primary and secondary research. Primary research formed the bulk of our research efforts along with information collected from telephonic interviews and interactions via e-mails. Secondary research involved study of company websites, annual reports, press releases, stock analysis presentations, and various international and national databases.

The report provides market size in terms of US$ Mn for each segment for the period from 2014 to 2024, considering the macro and micro environmental factors. Growth rates for each segment within the global Cell Expansion market have been determined after a thorough analysis of past trends, demographics, future trends, technological developments, and regulatory requirements.

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A detailed qualitative analysis of factors responsible for driving and restraining market growth and future opportunities has been provided in the market overview section. This section of the report also includes market attractiveness analysis that provides a thorough analysis of the overall competitive scenario in the global cell expansion market.

Market revenue in terms of US$ Mn for the period between 2014 and 2024 along with the compound annual growth rate (CAGR %) from 2016 to 2024 are provided for all the segments, considering 2015 as the base year. Market size estimations involved in-depth study of services and product features of different types of services. Additionally, market related factors such as increase in prevalence of cancer and rare diseases, rise in demand for regenerative and cell-based therapies and historical year-on-year growth have been taken into consideration while estimating the market size.

Global Cell Expansion Market: Segmentation

The cell expansion market has segmented into four categories, namely by type of cells, by product, by end-user and by region.

Geographically, the global Cell Expansion market has been segmented into five regions: North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. In addition, the regions have been further segmented by major countries from each region. These include the U.S., Canada, the U.K., Germany, France, Italy, Spain, China, Japan, India, Saudi Arabia, UAE, Brazil, and Mexico.

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Global Cell Expansion Market: Competitive Landscape

The report also profiles major players in the cell expansion market based on various attributes such as company overview, financial overview, SWOT analysis, key business strategies, product portfolio, and recent developments. Key companies profiled in the report include GE Healthcare, Danaher Corporation (Pall Corporation), Terumo Corporation, Merck Millipore (Merck KGaA), Octane Biotech, Inc., Thermo Fisher Scientific, Inc., Lonza Group, STEMCELL Technologies, Inc., Becton, Dickinson and Company, Bio-Techne (R&D Systems), Takara Bio, Inc., Cell Signaling Technology, Inc., PeproTech, CellGenix GmbH, Corning Incorporated, Eppendorf AG, and HiMedia Laboratories.

The global cell expansion market is segmented as follows:

Global Cell Expansion Market Revenue, by Type of Cells Human Cells Stem Cells Adult Stem Cells Induced Pluripotent Stem Cells Embryonic Stem Cells Differentiated Cells Animal Cells

Global Cell Expansion Market Revenue, by Product Type Instruments Cell Expansion Supporting Equipment Bioreactors Automated Cell Expansion Consumables Reagents Media Sera Disposables Bioreactor Accessories Tissue Culture Flasks Others

Global Cell Expansion Market Revenue, by End User Hospitals CMO & CRO Biotechnology & Pharmaceutical Companies Academic & Research Institutes

Global Cell Expansion Market Revenue, by Geography North America US Canada Europe UK Germany France Italy Spain Russia Rest of Europe Asia Pacific China Japan Australia & New Zealand Rest of Asia Pacific Latin America Brazil Mexico Rest of Latin America Middle East and Africa South Africa GCC Countries Rest of Middle East & Africa

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Cell Expansion Market is expected to rise at a remarkable CAGR during the Forecast Period 2016 2024 - Space Market Research

Yale researchers develop way to help brain organoids thrive – Yale News

Brain organoids created from human embryonic stem cells offer scientists a powerful way to study the developing brain in three dimensions. However, organoids need nutrients and oxygen carried in blood to thrive, just as a developing fetal brain does. Now Yale researchers have developed a method to induce growth of blood vessels in organoids and prevent the death of cells, which has hindered efforts of scientists studying brain development, they report Oct. 7 in the journal Nature Methods.

The introduction of vasculature will hopefully lead to our ability to create larger, healthier organoids, said In-Hyun Park, associate professor of genetics and associate professor in the Child Study Center and Yale Stem Cell Center.

The development of organoids, created by spurring development of human embryonic stem cells, has been a boon to neuroscientists studying the origins of neurodevelopmental diseases such as autism and schizophrenia, which can arise from abnormalities that form early in brain development. Although just a few millimeters in diameter, organoids offer a new window into how developing regions interact in real time.

However, organoids are also prone to widespread death of cells caused by a lack of blood vessels, particularly within the interior of the developing organ. Parks lab overcame that problem by inducing the expression of hETV2, a gene associated with the creation of vasculature in the developing embryo, within human embryonic stem cells. Its studies, led by Bilal Cakir and Yangfei Xiang, found that cell death in the organoids with engineered cells dramatically decreased, but that new blood vessels were created when the organoids were transplanted into a mouse.

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Yale researchers develop way to help brain organoids thrive - Yale News

Catholics more motivated to donate if ethical investing is assured – The Catholic Spirit

An usher hands the collection basket to a Massgoer Oct. 28, 2018, at Jesus the Divine Word Church in Huntingtown, Md. Nearly nine in 10 Catholics surveyed said they want their donations to church institutions to be ethically invested and a majority of those responding voiced particular opposition to investments in companies that produce pornography, tobacco products and e-cigarettes, according to a new survey. CNS photo/Bob Roller

The survey for Boston-based Catholic Investment Services found that about 87% of respondents would be more likely to donate to Catholic institutions if they knew the money would be invested in ways consistent with Church teaching and values.

In contrast, about 14% of respondents said ethical investing was not a consideration when donating to Catholic institutions.

The results parallel those of a CIS survey released in April. Peter Jeton, the firms outgoing CEO, said the new study sought to more specifically identify what investments motivates or deters Catholics to give to Church entities.

People want their donations to go where its good and avoid evil, Jeton said.

Ethical investing can be a motivating factor in how much people give, he told Catholic News Service. And if I am the CFO (chief financial officer) of a diocese or if Im the bishop of a diocese, then I should be explaining very clearly and with frequency what the policy is regarding how peoples money is being invested.

The survey involved 500 Catholic adults who answered a series of online questions Sept. 7-9. It has a margin of error of plus or minus 4.5 percentage points.

It covered more than a dozen types of businesses from manufacturers of medications used during an abortion procedure to oil and natural gas mining to which respondents voiced objections.

In the case of the pornography industry, 60% of respondents said Church money should not be invested in such endeavors. Opposition also was raised to investing in tobacco products and e-cigarettes (57%), alcoholic beverages (52%), medications used during an abortion (52%), casinos and gaming (51%), medical facilities where abortions occur (50%), gun manufacturing (47%), for-profit prisons/detention centers (45%), security, defense and large-scale weapons (44%), research on embryonic stem cells (37%), manufacturers of birth control (31%) and oil and natural gas extraction (30%).

Jeton suggested that institutional financial officers and bishops be fully transparent about their investment decisions. The better the engagement, the better for the Church, he said.

They should emphasize the link with Catholic social teaching, he added. Because if our data is correct, then making people in the pews aware of that should, by all rights, increase the comfort level with the Church and a greater willingness to share more of their financial resources with the Church.

The survey also asked participants what investments Catholic institutions should be making. Among those cited by respondents were clean air and water (67%), workforce education/job training (66%), education technology (65%), agriculture and food (65%), health care providers (62%), affordable housing (60%), recycling (57%), renewable energy (53%), land conservation (50%), fitness/nutrition (49%) and banking and financial services to low-income people and small businesses (46%).

Catholic Investment Services was founded in 2013 to serve Catholic entities, including dioceses, colleges and universities, hospital systems and social service agencies. Jeton said the firm follows the socially responsible investment guidelines adopted by the U.S. Conference of Catholic Bishops.

Those guidelines, in place since 2003, are divided into six broad categories: protecting human life, promoting human dignity, reducing arms production, pursuing economic justice, protecting the environment and encouraging corporate responsibility. Each category lists specific areas of concern, such as abortion, racial discrimination, labor standards and other social needs in which the Church has had a voice.

Jeton said he hoped the data developed would influence how diocesan bishops in particular discuss finances with the folks in the pew.

They would do well to pay attention to mechanisms that would get more people engaged, Jeton said. Hopefully with greater engagement there is growing willingness (among donors) to go into their back pocket to help the Church.

Tags: Catholic Investment Services, Ethical investing

Category: U.S. & World News

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Catholics more motivated to donate if ethical investing is assured - The Catholic Spirit

Stem Cell Market: By Key Players, Market Competitive Landscape, Trends and Forecasts to 2024 – Joliet Observer

Global Stem Cell Market 2019 Analysis to serve a detailed research of primary, of this world, in-between and long-term trends to support the growth of already established challengers, emerging new companies and the detailed growth rate. This report also withgrowth trends,numerousstakeholders like investors, CEOs, traders, suppliers,analysis& media,internationalManager, Director, President, SWOT analysis i.e. Strength, Weakness, Opportunities and Threat to the organizationand others.

Top most List manufacturers/ Key player/ Economy by Business Leaders Leading Players of Stem Cell Market Are: CCBC, Vcanbio, Boyalife, Beikebiotech, . And More

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Overview of the Stem Cell Market:

Stem cells are a class of undifferentiated cells that are able to differentiate into specialized cell types. Commonly, stem cells come from two main sources: Embryos formed during the blastocyst phase of embryological development (embryonic stem cells) and Adult tissue (adult stem cells).,

Stem Cell Market Segment by Type covers:

Stem Cell Market Segment by Applications can be divided into:

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Stem Cell Market: By Key Players, Market Competitive Landscape, Trends and Forecasts to 2024 - Joliet Observer

Stem Cell Therapy Market to Witness a Pronounce Growth During 2020 – Gem Newz

Stem cells are most vital cells found in both humans and non-human animals. Stem cells are also known as centerpiece of regenerative medicine. Regenerative medicines have capability to grow new cells and replace damaged and dead cells. Stem cell is the precursors of all cells in the human body. It has the ability to replicate itself and repair and replace other damaged tissues in the human body. In addition, stem cell based therapies are used in the treatment of several chronic diseases such as cancer and blood disorders.

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The global stem cell therapy market is categorized based on various modes of treatment and by therapeutic applications. The treatment segment is further sub-segmented into autologous stem cell therapy and allogeneic stem cell therapy. The application segment includes metabolic diseases, eye diseases, immune system diseases, musculoskeletal disorders, central nervous system disorders, cardiovascular diseases and wounds and injuries.

In terms of geographic, North America dominates the global stem cell therapy market due to increased research activities on stem cells. The U.S. represents the largest market for stem cell therapy followed by Canada in North America. However, Asia is expected to show high growth rates in the next five years in global stem cell therapy market due to increasing population. In addition, increasing government support by providing funds is also supporting in growth of the stem cell therapy market in Asia. China and India are expected to be the fastest growing stem cell therapy markets in Asia.

In recent time, increasing prevalence of chronic diseases and increasing funds from government organizations are some of the major drivers for global stem cell therapy market. In addition, rising awareness about stem cell therapies and increasing focus on stem cell research are also supporting in growth of global stem cell therapy market. However, less developed research infrastructure for stem cell therapies and ethical issues related to embryonic stem cells are some of the major restraints for global stem cell therapy market. In addition, complexity related with the preservation of stem cell also obstructs the growth of global stem cell therapy market.

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Some of the major companies operating in the global stem cell therapy market are Mesoblast Ltd., Celgene Corporation, Aastrom Biosciences, Inc. and StemCells, Inc.

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Stem Cell Therapy Market to Witness a Pronounce Growth During 2020 - Gem Newz