Stem Cell Clinic

Avoidable blindness: making global sight loss a thing of the past – Raconteur

Sight, the precious sense that brings us perspective and wonder, is under unprecedented attack. Despite huge clinical and technological advances, record numbers of people are suffering from avoidable blindness.

The economic burden of sight loss has been estimated at 28.1 billion a year in the UK, yet more than 50 per cent of blindness is avoidable.

These stark statistics are made even more disturbing by the fact that, while health and longevity profiles across all disabilities are improving, sight loss is becoming worse.

People think of eye checks as a case of if you need spectacles or not, so a cultural change in understanding is needed

Research projects are bringing us bionic eyes, stem cell regrowth and artificial intelligence (AI) that can combat the ravages of eye disease. But they are ranged against formidable harbingers of darkness in obesity, outmoded systems, poor funding and ageing populations.

It is a healthcare battle of our time. The rise of type-2 diabetes has led to an alarming climb of diabetic retinopathy over the last decade and, with more than five million people predicted to have the condition by 2025, the burden can only increase.

The maelstroms force is accelerated by an ageing population suffering from natural sight loss and a stressed healthcare system that results in huge delays for basic sight-saving treatment and an acute shortage of ophthalmologists in training.

The All-Party Parliamentary Group (APPG) on Eye Health and Visual Impairment reported in June 2018 that sight loss is projected to increase by more than 10 per cent by 2020 and by 40 per cent by 2030.

Ophthalmology has the second highest outpatient attendance of any specialty with a 10 per cent increase over the last four years to almost 7.6 million appointments in 2016-17 in England, yet there is a chronic shortage of ophthalmology consultant posts.

A report from the Royal College of Ophthalmologists in 2018 warned that 67 per cent of hospital eye units were using locum doctors to fill consultant posts, an increase of 52 per cent since 2016, and that around 25 per cent of the current specialist workforce is nearing retirement.

Lack of provision has a cascade impact on health and wellbeing as evidenced by APPG research, which found 70 per cent of patients felt appointment delays and cancellations caused them anxiety or stress.

More than 50 per cent of blindness is preventable and the main causes are disease processes that could have been detected early enough to slow it down, or uncorrected short or long sight, says Louise Gow, specialist lead for RNIB. No one should be visually impaired because they havent had access to care to prescribe glasses.

The major disease causes of blindness diabetic retinopathy, cataracts, glaucoma, wet age-related macular degeneration (AMD) are all amenable to treatment if diagnosed early enough.

We should be making sure that in this country people are not losing their sight when it could have been prevented, says Ms Gow. We have a fantastic ophthalmology service on the NHS, but it is under so much strain. Lots of patients experience delays for follow-up appointments and getting into the system, so they present with later-stage eye disease or do not even access the services and treatment they need. We need more ophthalmologists trained, and to utilise the skills of optometrists and dispensing opticians to take some of the strain from hospitals.

Dr Andy Cassels-Brown, medical director of the Fred Hollows Foundation, an international development agency working to eliminate avoidable blindness, underscores the need for medical and technical advances to be matched with system upgrades.

While new technology is part of the solution to eliminating avoidable blindness, it wont be the single solution, he says. Breakthroughs will also come in the form of new models of care that deliver services to more people and those most in need.

Governments will need to oversee health systems, drive the adoption of affordable technologies and make them available to the most in need.

The need to harness brilliant innovation with the more prosaic system design is writ large in glaucoma, a condition that slowly damages the optic nerve and erodes sight. Around 900,000 people in the UK have the condition, but public awareness is so low that around 500,000 are unaware they have it and could suffer irreversible sight loss. Regular eye tests and faster routes to treatment could turn around an insidious problem that will lead to the loss of livelihood and independence.

The optical profession has started asking itself why enough people dont get tested and one of the answers is for opticians to follow pharmacists in providing more services to patients and relieve the burden on GPs, says Karen Osborn, chief executive of the International Glaucoma Association. People understandably think of eye checks as a case of if you need spectacles or not, so a cultural change in understanding is needed because there are so many other health conditions that can be picked up.

It is a sobering challenge, but eye health is awash with inspiring projects that have taken bionic eyes and regenerating optic cells from hope to reality.

Professor Paulo Stanga of Manchester University has successfully implanted bionic eye systems a prosthesis linked to a visual display unit in a pair of spectacles to restore some functional sight to patients with retinitis pigmentosa, an inherited disease that causes blindness and AMD. Trials, funded by the NHS, are continuing and proving that a future where avoidable blindness is drastically reduced is more than just a dream.

Research is also progressing at Londons Moorfields Eye Hospital NHS Foundation Trust to tackle the diagnostic challenge. Its collaboration with DeepMind Health, part of Googles healthcare division, uses AI technology to detect eye conditions automatically in seconds and triage patients to the right treatment, reducing the chances of sight loss.

It claims a 94 per cent accuracy rate on eye-scan analysis and could, if clinically validated, reduce diagnosis time, release consultants for other work and create a data reservoir to improve future research.

Dr Pearse Keane,consultant ophthalmologist at Moorfields Eye Hospital, says: Our work with DeepMind Health is using artificial intelligence to detect abnormalities in patients eye scans. This has the potential to provide a much faster diagnosis, which is vital in preventing sight loss from a number of conditions, including age-related macular degeneration and diabetic retinopathy.

Avoidable blindness is verging on a national tragedy and it will need a concerted effort from campaigners, clinicians, scientists, and public health and government policy to ensure people can retain the gift of sight throughout their lives.

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Avoidable blindness: making global sight loss a thing of the past - Raconteur

I turned down chemo after being diagnosed with terminal cancer and lived then I became pregnant after d – The Sun

AT 26 years of age, Abi Flynn received the devastating news she had terminal blood cancer and a large tumour in her chest.

After two years of chemotherapy failed to have any effect, the singer-songwriter decided against doctors advice to walk out of hospital and give up on the potentially life-saving treatment she was told she needed.

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Incredibly, the tumour in her chest began to shrink. And three months later, stunned doctors discovered she was in remission.

However, after five gruelling rounds of chemo and the removal of one of her fallopian tubes, she was told she was infertile.

There was to be one more miracle though two months after being given the all-clear, Abi discovered she was pregnant.

Cradling her eight-month bump, thrilled Abi, now 29, says: When I finished chemo and radiotherapy and left the hospital in June last year, doctors told me I would likely die unless I had a stem-cell transplant. I stopped all treatment because I felt it was just making my illness a lot worse.

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Id turned down the transplant and taken a terrifying risk.

But now, all of a sudden, I wasnt dying, and two months after getting the all-clear I was pregnant. Its a miracle, just unbelievable.

Abi first went to her GP with extreme chest pain in August 2016.

She says: Doctors believed I had a lung infection and referred me for further tests.

My world was turned upside down when I was diagnosed with Hodgkins lymphoma, a rare blood cancer, which had caused a tumour in my chest.

I found the diagnosis hard to believe. I hadnt even thought about getting cancer at such a young age. I was very tearful.

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Abi began a two-year battle through five rounds of chemo and a months intensive radiotherapy, which left her bedridden and breathless.

She says: Doctors told me the 21cm tumour was unresponsive to chemotherapy but warned I would most likely die without further medical help.

My immune system was so weak that the cancer continued to spread. Radiotherapy was the worst because I felt the effects around one month afterwards, not while I was having it.

In June last year, I decided to stop all treatment. If I had the stem-cell transplant, I worried it would leave me vulnerable to all kinds of illnesses.

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My body had been through so much and the chemotherapy had left me infertile.

This was hugely upsetting because I always knew I wanted to be a mum.

Doctors warned me that a relapse, meaning the cancer in my blood could come back, was extremely likely if I didnt have the transplant and that I could die within months, maybe weeks.

When Abi went back to hospital four months later, in June 2018, for a check-up, doctors were amazed to discover the tumour had shrunk from 21cm to 8cm and had died, meaning that she was in remission. She says: I was so scared on the way to my scan, but finding out it had shrunk and died was incredible.

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And in September 2018, a second scan showed the tumour had shrunk again to just 7cm, and I was officially given the all-clear.

Doctors were surprised and confused as to why the cancer suddenly reversed and thought it was an anomaly. They said my recovery defied medical statistics.

I have been given no explanation why it suddenly reversed.

Two days before her all-clear scan, Abi met motivational speaker Bradley Wescott, 33, at an event. The pair hit it off and became an item. Five months later they were amazed to discover they were going to be parents.

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Abi, of Hove, East Sussex, says: I went on a holiday to India and realised my stomach was bigger and my period was late.

The day after I got home, Bradley asked if I should take a pregnancy test and we discovered the incredible news.

He was thrilled and so was I. Its made us closer and stronger.

We cant wait to meet our new arrival, a little boy who is due next month.

Im so excited. I feel like I already know my baby boy.

Its a testament to just how incredible my journey has been.

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My view - by Carole Cooper

HODGKINS lymphoma is a cancer that develops from white blood cells called B-lymphocytes.

The disease can be aggressive and spreads rapidly to other areas, such as the lungs and liver.

Even so, it is usually very treatable. Nearly 90 per cent of people who develop Hodgkins survive for five years and many are cured for good.

Treatment often involves radiotherapy as well as chemo, which is tough. It can be a struggle to continue, but specialists are very experienced with this type of lymphoma and can offer the very best advice and treatment.

While every case is different, young women often do better than other people who have Hodgkins.

All the same, Abi is extremely lucky to have done so well after giving up on treatment, and her bonus baby is a near-miracle.

Most stories like this have a sad outcome. Thats why I advise people to discuss difficult issues with their doctor rather than defy medical opinion and just walk out the door.

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I turned down chemo after being diagnosed with terminal cancer and lived then I became pregnant after d - The Sun

Football Players? Or Lab Rats Who Can Run and Pass? – The New York Times

BATON ROUGE, La. The new training room in the $28 million football operations building at Louisiana State features jetted tubs, antigravity treadmills and sodium-infused water coolers. A room nearby holds another piece of equipment tucked out of sight: a centrifuge.

It is another example of how modern efforts to improve performance in big-time college athletics have moved beyond smoothies and sleep monitors. The centrifuge is used for blood work for injury treatments such as platelet-poor plasma therapy and stem-cell injections.

L.S.U. players also regularly have their sweat analyzed for nutritional deficiencies. They swallow digestible electronic pills that monitor body temperature. This summer, a dozen athletes wore neuroimaging headgear for the first time to get a peek at how their brains function in simulated athletic conditions.

Colleges have long boasted about world-class research laboratories and world-class athletic programs. Lately, the chances are greater that the two will intersect.

The rapid increase in slick gadgetry dedicated to collecting and analyzing biometrics now factors into the recruiting arms race for the top programs in college football. It has also prompted questions about player privacy and, in some cases, criticism over athletic spending for everything but player compensation.

Last fall, Clemson opened its Applied Sports Lab right in its football facility. It features a green screen and motion imaging technology that can capture detailed movements of each player. Two years earlier, Alabama unveiled an interdisciplinary center for health science and athletic training.

The University of Oklahoma collects urine samples from athletes for hydration studies, and football players at the University of Memphis sometimes wear sensors as they walk around campus to measure the amount of daily force exerted on their legs.

The University of Nebraskas Athletic Performance Lab has a system to measure blood flow in the brain. West Virginia has added far-infrared heat therapy pods, float tanks and cryotherapy chambers to its football recovery suite.

This suffusion of science onto the playing field is affecting all aspects of training, treatment and even player evaluation informing coaches how to maximize the efficiency of their athletes or perhaps to decide which of them belong on the bench. Many of these same coaches used to resist having many doctors and scientists around their team. Now, they are embracing the potential of the latest technology in the hands of skilled practitioners.

I love it, L.S.U. Coach Ed Orgeron said. Its the facts. Its not emotions.

Orgeron watched keenly last year as his wide receivers and tight ends ran routes wearing goggles that monitored their pupils to detect which eye they favored when catching passes.

That helped Orgerons assistants design better routes for the receivers. A similar test for defensive linemen could help them get off the snap quicker, Orgeron said.

Few places have been as willing to experiment as L.S.U., where the football support staff includes two kinesiologists from the universitys Pennington Biomedical Research Center and a full-time sports science research associate. They meet with the athletic trainer, Jack Marucci, three times a week.

Together, they have brainstormed some intriguing approaches to football players performance and wellness. There is, for instance, on the practice field, a 40-foot shipping container, chilled to 49 degrees, in which players can instantly cool down during hot summer workouts. Inside are two rows of bleachers for seating.

The locker room inside the newly renovated practice complex reflects the teams latest response to sleep science. Each of the 120 lockers contains a foldout bed, inspired by the fully reclinable seats in the first-class cabins of some planes. The lockers even have filtered air piped into their storage drawers to reduce the odor of used equipment.

L.S.U.s reveal of the locker rooms was lambasted from other parts of the campus, with professors and others on social media saying the universitys money should have been spent elsewhere. The school responded by saying all spending for the renovations came from private athletic donations.

Marucci, 55, considers the locker pods a game changer for recruiting. But for science and research, he is even giddier about the immersive virtual-reality room, complete with down markers for the team to simulate game situations.

Marucci is far better known for the eponymous wooden bat company he started out of his garage in 2004; today, more hitters in Major League Baseball swing Marucci lumber than any other brand.

When he is not traveling to baseball stadiums, he is typically evaluating one of the 15 new sports science product pitches he receives on average by email every day. Most are deleted. Not all.

When the Tigers find something they like, a result can be a full-blown makeover. Three years ago, after a spate of dehydration episodes, the staff analyzed players perspiration with wearable patches. Their conclusion: The athletes needed to be ingesting far more sodium.

So the trainers started dumping sodium tablets into the sideline coolers. The cafeteria chefs were instructed to be generous with the salt. And Marucci traveled to the Coca-Cola headquarters in Georgia to meet with executives about a Powerade machine that could customize drinks with precise amounts of sodium, electrolytes or sugar.

These machines are our water fountains now, Marucci said. The players will have their own custom drinks. If a guy needs to lose weight, he doesnt need to have as many carbs or sugars in his drink. We can identify guys that are cramping so we can add more sodium to his drink.

In some cases, the sodium obsession has gone beyond fluids. An L.S.U. tennis player with a tendency to cramp didnt love the taste of Powerade, so the trainers gave him cans of high-sodium Campbells soup to eat before matches.

He cramped one time all season, said Nathan Lemoine, the research associate. Why? He didnt take his soup.

For additional studies, the Pennington lab, Marucci said, is equipped with $200,000 cameras for biomechanics, scanners for body composition assessments and magnetic resonance imaging machines for concussion examinations. Were using all our resources, Marucci said. We have the access to the players, he added, and they have the expertise.

For years, coaches tended to oppose lending athletes to the scientists. Testing equaled time. And coaches stay protective of time.

But the rise of more consumer-friendly (and expeditious) equipment combined with savvy marketing has changed that. As teams started investing in more tools like wearable GPS technology for player-movement tracking all the data gathered often fell in the lap of a strength coach or a trainer. Those coaches then turned to scientists to interpret the analytics.

Thats how I started at Ohio State, said Josh Hagen, now the director of the Human Performance Innovation Center at West Virginia. I saw they were overwhelmed with data. I was like, Hey, Id love to help you with that.

He added, As long as you can provide a direct benefit to their daily routine, thats your ticket in.

Coaches began to see the benefits, too, particularly as a recruiting chip for attracting young athletes who have grown up natively comfortable with technology. These kids are different, Orgeron said. Theyre going to try stuff. Theyre reading about it, and they want to be a part of it.

Others have urged more caution. Warren Zola, a sports law professor at Boston College, has watched the proliferation of sports science technology advance from wearables to the more invasive techniques, like blood and urine analyses. And he wonders about how all that data might be used, who gets to use it and who gets to keep it.

I have no doubt that these institutions are developing these athletes in ways that they think will enhance their abilities and skills, Zola said. The question is, Who is looking out for the students?

Unlike professional sports, college athletes have no union supporting them or agent reading through the fine print of how a neural assessment might impact their playing time or draft position.

If youre an 18-year-old recruit on a football team, Zola said, are you willing to stand up to your coach and say: No, I dont want you to draw my blood because I dont know how youre going to use it or protect it. You may be trying to help me, but there may be stuff I dont want to know.

Marucci said participation in the various studies and biometric data collection at L.S.U. is voluntary; not everyone agreed to participate and there were no repercussions. One particular research request the digestible electronic pill did have a few players raising their eyebrows.

One of the first questions they asked me is, Are you tracking me? Lemoine said with a laugh. The answer is no.

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Football Players? Or Lab Rats Who Can Run and Pass? - The New York Times

Daleiden: sworn testimony exposed Planned Parenthoods crime of trafficking aborted-baby body-parts – Lifesite

SAN FRANCISCO, California, September 20, 2019 (LifeSiteNews) Pro-life undercover journalists David Daleiden and Sandra Merritt are hopeful that sworn testimony over the past weeks in San Franciscos Superior Court demonstrates that those who trafficked aborted-baby body parts are guilty of crimes, not the whistleblowers who exposed it.

We think the charges should be thrown out, Daleiden told LifeSiteNews.

The really shocking and troubling and clarifying truth that was exposed in the courtroom for the past two weeks here is that its very, very clear that the only crimes that were committed in the course of the undercover videotaping that Center for Medical Progress did were the crimes committed by the Planned Parenthood abortion doctors, and by the StemExpress body parts harvesters who were forced to testify under oath these past two weeks, he said.

The criminal preliminary hearing for Daleiden and Merritt ended Wednesday after stretching into three weeks. Judge Christopher Hites ruling on whether the case will proceed to trial is expected within a month.

Daleiden, project lead for the Center for Medical Progress (CMP), and Merritt, an undercover reporter with CMP, are charged with 14 felony counts of recording confidential conversations without consent in connection with CMPs undercover videos released in 2015 exposing Planned Parenthood trafficking in baby body parts. They face up to 10 years in jail if convicted.

The groundbreaking undercover videos showed Planned Parenthood executives and workers haggling over the prices of baby body parts, picking through bloodied arms and legs of aborted babies in a pie tray, and discussing how to alter abortion methods to obtain better body parts for sale.

Public outrage over the videos prompted congressional hearings and calls for the federal defunding of Planned Parenthood.

The preliminary hearing ran nine-and-a-half days between September 3 to 18, and Judge Hite will decide based on evidence if there is probable cause to continue to trial.

Daleiden and Merritt are claiming a Section 633.5 defense that allows covert recording of confidential communications when done to collect evidence of violent crimes.

Defense is also arguing that the law does not consider confidential any conversation that can reasonably be expected to be overheard.

The hearing saw high-level Planned Parenthood abortionists along with the CEO of baby parts harvesting company StemExpress dodging questions on their gruesome business under cross-examination by pro-life defense lawyers.

It was the venue for Daleidens first-ever public testimony about why he embarked on a 30-month undercover sting operation into Planned Parenthood trafficking in aborted baby parts and how he penetrated the networks of those involved in the grisly and illegal business.

It included a cross-examination of investigating agent for the Department of Justice Brian Cardwell that showed he did next to nothing to find out if those accusing Daleiden and Merritt of illegally taping them were telling the truth or understood confidentiality as defined in the law.

It featured defense testimony by one of the United States longest-practicing abortionists Dr. Forrest Smith. He testified that it is almost certain that some of the abortionists featured in the undercover videos deliberately altered abortion procedures in a way that both led to the birth of living babies with beating hearts and put women at risk. The goal in such abortions would be to obtain fresher, more intact organs.

In one dramatic moment,the attorney general unsuccessfully seeking a gag order on defense attorneys that cited a LifeSite news article after the CEO of StemExpress filed a complaint with Cardwell following her testimony that she feared for her security. In another, the defense accused the attorney general of trying to intimidate their star witness Dr. Theresa Deisher by suggesting she might be a target of criminal prosecution forallegedly being a co-conspirator in Daleiden'a undercover operation, which Deisher in subsequent testimony said she knew nothing about.

The hearing ended Wednesday with the riveting testimony of stem cell expert Dr. Deisher that human hearts used in research must be harvested from living babies. Daleiden testified earlier in the hearing he discovered a Stanford study using human fetal hearts supplied by StemExpress.

The expert testimony from brilliant scientists like Dr. Deisher just goes to show why the whole reason why I and my colleagues like Sandra Merritt and others did our undercover work with the Center for Medical Progress, Daleiden told LifeSiteNews.

Because theres very compelling evidence that the most valuable organs and tissues from aborted children are harvested from aborted children while theyre still alive. Those kids are actually killed through vivisection and that is a human atrocity that has to be exposed.

The defense also tried to have the search warrant that led to the criminal prosecution quashed, arguing that seizing Daleidens unpublished source material was unconstitutional and the prosecution politically motivated. Judge Hite denied the motion.

The political nature of the case is no secret, and testimony and evidence presented at the preliminary hearing exposed this completely bogus, sham, politically motivated case for the farce that it is, Daleiden told LifeSite.

Documents from the case now on public record show former Attorney General Kamala Harris had an in-person meeting at the attorney generals meeting in Los Angeles with no less than six top-level Planned Parenthood of California executives, he said. Daleiden added that the meeting took place a couple of weeks before Harris ordered Department of Justice agents to raid his Orange County apartment in April 2016 and seize all his recording materials, including unpublished source documents of his undercover investigation.

We have the minutes in an email from the meeting that Kamala had with the Planned Parenthood leadership, and in that meeting they discussed both Planned Parenthoods political agenda in the state of California, and they also discussed the attorney generals investigation of me and of CMP, Daleiden said.

There were two Planned Parenthood witnesses in Harriss investigation into CMP present for both discussions, he said.

So there was no separation whatsoever between what Kamala Harris was doing as a politician for her backers at Planned Parenthood, and what she was doing as the top law enforcement officer in the state of California, he told LifeSiteNews.

She was prostituting her law enforcement powers to the service of her political backers at Planned Parenthood, and thats very corrupt, and very bad, and very wrong, and that should never happen to any person in the United States of America, Daleiden said.

Its a gross violation of my civil rights and of the civil rights of all people in California.

The two witnesses were Dr. Jennifer Russo, medical director of Planned Parenthood of Orange and San Bernardino counties, and Anna Sandoval, communications director for PP affiliates of California.

Russo was the one who was in charge of supplying body parts to the criminal Da Vinci companieswho have since been shut down, he said.

So you can imagine the sort of interest that Dr. Russo and Planned Parenthood of Orange county had at that time to try and create an alternative fake prosecution against me and against CMP.

Daleiden is now preparing for the month-and-a-half trial in the Planned Parenthood civil suit against him, CMP, and CMP undercover reporters that begins October 2.

We will be facing down against, I think 10 or 11 different Planned Parenthood affiliates in San Francisco federal court in Judge [William] Orricks courtroom, he said.

Judge Orrick was the founder and funder of a Planned Parenthood Northern California clinic here in San Francisco, which is also one of the plaintiffs in this case, Daleiden said.

Another plaintiff in the lawsuit is Planned Parenthood Orange County who had been selling late-term baby body parts to the Da Vinci companies for years and years and years, he told LifeSiteNews.

As a direct result of the evidence collected in the CMP undercover investigation, the Da Vinci companies were shut down by the Orange County district attorney and liquidated in a $7.8 million settlement in which they admitted guilt for selling baby body parts against the law, Daleiden said.

A number of Planned Parenthood abortionists who testified at the criminal preliminary hearing will be doing so in the civil case, he said.

If the past two weeks here at the prelim are any indication, the Planned Parenthood witnesses are not ready for primetime, Daleiden told LifeSiteNews.

Theyre not credible, theyre not honest, theyre not ethical, and the things that theyve been doing are not legal, call them anything you want, and theyre not pretty.

He believes that Planned Parenthood will ultimately face justice.

I dont think that the Da Vinci companies are going to be the last company like that, who are going to face justice under the law in that way, Daleiden said, adding that there were many criminal referrals sent out from the congressional investigations of Planned Parenthood.

So were still waiting to get an update from the Department of Justice and the FBI about where that stands with Planned Parenthood, he said.

The Senate Judiciary committee requested an update over the summer from them, so were waiting to find out from the Senate Judiciary Committee if they got that update and what it said, added Daleiden.

I think we should all stay tuned.

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Daleiden: sworn testimony exposed Planned Parenthoods crime of trafficking aborted-baby body-parts - Lifesite

Mum’s tireless campaign as daughter, 2, is kept alive by blood donors – Yahoo News Australia

A mum is pleading for people to donate blood after her two-year-old daughter was struck by an undiagnosed illness that left her the size of a one-year-old.

The toddler is being kept alive by blood donations.

Former medical administrator Steph Davidson, 25, and her 27-year-old husband Jordan were thrilled to welcome their daughter, Adeline, in November 2016.

But her joyful birth was marred by a bowel obstruction which required surgery.

Adeline, from Alness in Scotland, recovered well, but Steph noticed her daughter was always small for her age.

At the age of one she was wearing clothes for children aged up to six months old.

The mother of a two-year-old girl has urged people to donate blood after she was struck down by a mystery illness. Blood donations are keeping her daughter alive. Source: mediadrumworld.com/@adelinebluesjourney_x

In 2018 Steph made an appointment to see a paediatrician, but the four-month wait delayed this until February 5, 2019.

The paediatrician noted how pale Adeline looked, although she seemed otherwise healthy.

Nonetheless, he did blood tests and just a few hours later Steph received a call asking her to come back in immediately.

Adelines blood tests revealed possible blood cancer and Steph was told to prepare for her not to come home.

Initially, doctors suspected leukaemia but when Adeline was transferred to Aberdeen Hospital, further tests confirmed it wasnt this particular cancer.

But doctors were no closer to a diagnosis.

Adeline was tested for chromosome mutations, genetic conditions, other types of cancer and doctors are now testing her genomes to find a diagnosis.

The two-year-old has very low platelets, red-blood cell and white-blood cell counts, which causes bruises, petechia, tiredness, breathlessness and paleness.

In March, doctors believed Adeline could have myelodysplasia, a blood cancer and bone marrow failure, but she shows signs which extend beyond this diagnosis although it hasnt been confirmed or ruled out.

Since her diagnosis, Adeline had to be pulled out of nursery for fears of infection or falling which would have devastating impacts on her weakened system.

Steph started sharing Adelines journey on@adelinebluesjourney_xto encourage more people to donate blood or become stem cell donors and has already seen almost 3000 more donors sign up and help save her daughters life.

The two-year-old is seen here receiving blood as doctors continue to try and diagnose an illness that leaves her the size of a one-year-old. Source: mediadrumworld.com/@adelinebluesjourney_x

Adeline was born with a bowel obstruction which led to her having surgery as she was a poor feeder, but even after surgery she remained a poor feeder, Steph said.

She struggled putting on weight and going up a clothes size, so at one she was still in size three to six months.

Story continues

Now, at almost three years old she wears 12 to 18 months.

I had been complaining about her weight and height for a while, but I eventually got an appointment with a paediatrician and had to wait four months. She hadnt put weight on for 18 months and was much smaller than other kids her age.

I always put it down to her bowel problems from birth, but little did we know there was something else unusual with Ads.

The paediatrician... took blood tests to check her iron levels... a few hours later I got a phone call asking to take Adeline in for results. I hesitated because it was a long way to go, so he told me over the phone that her bloods indicated a serious problem possibly blood cancer, Steph continued.

He told us to prepare for not coming home. My heart just stopped, I couldnt believe it and I was hysterical.

I was looking at Adeline, who to me was a healthy, happy, beautiful girl, but they were telling me she was seriously ill it didnt make sense.

While searching for a stem-cell match, Adelines blood tests have been reviewed internationally, in Canada and Germany among other countries, to widen the search.

Adeline needs a bone marrow transplant to save her life, but no full matches have been found yet so blood transfusions keep her stable until a match is found.

Low blood counts put Adeline at risk of infection, internal bruising and bleeding out through a small cut as her blood cannot clot as usual.

But Steph insists her battle with this mystery illness hasnt dimmed Adelines spirits as she maintains her lively personality and refuses to stop having fun.

It was planned that Adeline would have a Hickman line put in to allow blood to be taken, transfusions to be given, and any medicine can go through the lines too, Steph said.

This was the best news because it was becoming traumatic for Ads as each time she had to get bloods taken, it took five attempts. Her veins were so weak and small, so theyd often collapse or move when the needle went in.

She was an absolute star during the operation and calls her lines her toggles. Shes not phased in the slightest with this new accessory.

Australscope

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Mum's tireless campaign as daughter, 2, is kept alive by blood donors - Yahoo News Australia

3-day blood drive in Bathurst supports toddler with rare disease – CBC.ca

A three-day blood drive is being held in Bathurstto help increase the supply ofblood and plasma to help a toddler living with a rare disease.

Mavrik Hampewas only six months old when he was diagnosed withX-linked agammaglobulinemia (XLA), a disorder that affects the body's ability to fight infection.

"He was displaying signs of frequent infections that he just wasn't recovering from and infections that could cause a lot of damage for a little one," said his mother, Diane McKiel.

Mavrikhad multiple bouts of pneumonia along with the infections before a blood test showed he had no neutrophils, a type of white blood cell.

"They sent us immediately to the IWK in a plane and after a few days he wasn't producing any antibodies and they sent away for genetic testing."

At that point, X-linkedagammaglobulinemiawas confirmed.

McKielsaidMavrik, now 14 months old, will never produceantibodies in his blood to fight infections. He will require treatments of human immune globulin for the rest of his life.

"Everybody's learning through this process, both myself and his health-care providers."

McKieldescribes what they were living through as survival mode as they tried to find out what was wrong withMavrik.

"You just take everything day by day and you put your trust in the hands of many doctors that were involved."

McKielsaid blood donations are important forMavrik's survival because thehuman immune globulin is a plasma derived treatment from blood.

"This particular product, it takes thousands of donors to make this very concentrated formula ofimmune globulin."

He receives the treatment each month. He hasn't had a fever since he started the treatment.

"We couldn't have asked for a better outcome," said McKiel.

"As a mom, I was trying to figure out what can I do for him and what I can do for him is just make his story to be known and for people to be encouraged to go donate blood for this very reason."

McKiel had only given blood twice before her son's illness. Now she better understands theimportance of giving blood.

"I will be a lifetime donor now," she said. She has also registered as a stem-cell donor.

The blood drive will be held at theK.C. Irving Centre in the Paul Ouellette Room.

Donations can be made Monday from4:30-8:30 p.m., Tuesday from noon-3 p.m. and 4:30-7:30 p.m. and onWednesday from 1-3 p.m.and then 4:30-7:30 p.m.

"We will be there as a family throughout," said McKiel. "I want the city of Bathurst to see what they're doing for him. There's a little boy you're here helping and we're so happy and so grateful."

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3-day blood drive in Bathurst supports toddler with rare disease - CBC.ca

Bone marrow donor from Germany becomes recipient’s maid of honour – DNA India

For 30-year-old Steffi Mac, life took an unexpected turn, when she was just 24-year-old brimming with ideas and dreams. The young woman was detected with Acute Lymphoblastic Leukemia (ALL) or in simple terms blood cancer.

Immediate consultation with specialist doctors revealed that the only way to save Steffi's life was Bone Marrow Transplant. However, the lone solution came up with its own challenges.

As Steffi was the only child of her parents, there was no way that siblings could donate their bone marrow to her. Another setback was that her parents also could not donate the bone marrow to her because of matching issues.

She was taken to Christian Medical College, Vellore, in December 2013 where considering the risk to her life, the doctors and the hospital immediately started looking for a bone marrow donor for her.

However, not a single matching donor was found in the country. Eventually, the doctors found a matching donor from Germany in the DKMS registry, the world's largest bone marrow donor registry, and the transplant was carried out in March 2014. The transplant and the subsequent recovery was a painful process, but being a fighter, Steffi won the battle against cancer.

However, inside her mind, she desperately wanted to meet the person who saved her life. After innumerable requests and necessary permissions, she managed to get the email ID of the donor, wrote an emotional mail and then phone calls started between the two.

"I was communicating with her through emails and phone, but I just wanted to meet her in person, hug her, and tell her that she changed my life. For this, I went to Germany and when we met at the airport, we just cried like anything. I stayed with her for 10 days and it is a bond which cannot be explained in words," Steffi said.

Steffi added when she eventually got married last year, Aylin flew in from Germany with her friend and she was my maid of honour. Now, a lecturer with an Ahmedabad-based college and a corporate trainer, Steffi is actively working to create awareness on the issue of bone marrow donation and spoke on her journey against blood cancer on the occasion of World Marrow Donor Day organised by DATRI, India's largest unrelated blood stem cell donor registry.

On the occasion, three donors and their respective survivors were also present and spoke on the issue. The donorsDivyesh Shah, Binal Patel and Yashvant Polkar have saved a life and family by donating their blood stem cells.

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Bone marrow donor from Germany becomes recipient's maid of honour - DNA India

Tumor Marker Testing Market Size, Growth, Trends and 2023 Forecast Report – OnYourDesks

A biomarker is any cellular, physical, chemical, or molecular change that can be noted and a normal or abnormal process in human body can be studied. The effects of treatment, the presence, progress or risk for a disease can be checked by studying any alteration in the normal amount of a biomarker. A tumor marker, like a biomarker, is a naturally occurring substance in the body. An increased quantity of a tumor marker can show the presence of a cancer. Some tumor markers are related to several different types of cancer, while some are specific to one type of cancer. Tumor markers may also increase with non-cancerous conditions. A tumor marker can be prepared by cancer cells or by the body in response to cancer.

There are many different types of tumor markers such as human chorionic gonadotropin (HCG or b-HCG), cancer antigen 15-3 (CA15-3), alpha-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9), cancer antigen 125 (CA125), carcinoembryonic antigen (CEA), and prostate-specific antigen (PSA). Tumor markers can provide information that can be used for screening for cancer, diagnose cancer, determine stage of cancer, determine a persons prognosis, guide treatment, monitor treatment, and determine recurrence of the cancer. Some markers can be used in people with family history of a particular cancer. Prostate specific antigen can be used to screen for prostate cancer. Tumor markers can be used to help determine how far the cancer has spread into other tissues or organs. Some markers are used to determine how aggressive a cancer is likely to be. Some markers may help doctors predict what treatments the cancer is likely to respond to.

A tumor marker test is done to make available a baseline level before treatment, when any type of cancer is suspected, to check if cancer has returned after treatment being given, and to check a persons reaction to cancer treatment. Tumor markers are molecules found in urine, blood, and body tissues. It is a protein found in large amounts in presence of cancer. Hence, measuring the levels of tumor markers may help in detecting the presence of cancer. Presence of a tumor in body stimulates the production of tumor markers from tumor or non-tumor cells. The tumor marker testing market has been categorized based on diagnostic method, type of cancer, and technology employed for cancer detection. Organ specific tumor marker: bladder, breast, colorectal, gastrointestinal, liver, lung, oral, ovarian, pancreatic, prostatic, skin testicular cancer, leukemia, lymphoma, and others; Clinical laboratory methods for measuring tumor markers: Abbott diagnostics AxSYM, Roche Diagnostics System, Fischer Thermo Scientific B.R.A.H.M.S KRYPTOR and others; New technologies for cancer diagnostics: Monoclonal antibodies, proteomics, new protein markers, stem cell markers, DNA microassays and others; Clinical methods for cancer diagnosis: Screening, imaging, theranostics, sigmoidoscopy and others.

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Currently, cancer is the one of the leading causes of death in North America and Europe. North America holds the largest share of the tumor marker testing market, followed by Europe, due to vast discoveries and innovations for detecting cancer in early stages. Major factors driving the tumor marker testing market in these regions are rising incidence of cancer disease, increase in geriatric population, ongoing research in the field of cancer detection, and improved government reimbursement policies. However, high cost acts as a major restraint of the market.

Geographically, North America held the larger market share, followed by Europe. High research on tumor marker and increasing number of cancer patients in these regions are likely to boost the tumor marker testing market. However, affordability has become a restraining factor in this market in developing regions such as Asia Pacific and Latin America. However, the tumor marker testing market in Asia Pacific is expected to experience strong growth.

Major players in the tumor marker testing market are Abbott Diagnostics Ltd., Affymetrix, Inc., Agilent Technologies, Inc., Beckman, Dickinson and Company (BD) Diagnostics, BioCurex, BioModa, Inc., Clarient, Inc., Correlogic Systems, Inc., Epigenomics AG, Gen-Probe, Inc., Hologic, Inc., Roche Diagnostics Corp., and Veridex LLC, among others.

The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.

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The study is a source of reliable data on: Market segments and sub-segments Market trends and dynamics Supply and demand Market size Current trends/opportunities/challenges Competitive landscape Technological breakthroughs Value chain and stakeholder analysis

The regional analysis covers: North America (U.S. and Canada) Latin America (Mexico, Brazil, Peru, Chile, and others) Western Europe (Germany, U.K., France, Spain, Italy, Nordic countries, Belgium, Netherlands, and Luxembourg) Eastern Europe (Poland and Russia) Asia Pacific (China, India, Japan, ASEAN, Australia, and New Zealand) Middle East and Africa (GCC, Southern Africa, and North Africa)

The report has been compiled through extensive primary research (through interviews, surveys, and observations of seasoned analysts) and secondary research (which entails reputable paid sources, trade journals, and industry body databases). The report also features a complete qualitative and quantitative assessment by analyzing data gathered from industry analysts and market participants across key points in the industrys value chain.

A separate analysis of prevailing trends in the parent market, macro- and micro-economic indicators, and regulations and mandates is included under the purview of the study. By doing so, the report projects the attractiveness of each major segment over the forecast period.

Highlights of the report: A complete backdrop analysis, which includes an assessment of the parent market Important changes in market dynamics Market segmentation up to the second or third level Historical, current, and projected size of the market from the standpoint of both value and volume Reporting and evaluation of recent industry developments Market shares and strategies of key players Emerging niche segments and regional markets An objective assessment of the trajectory of the market Recommendations to companies for strengthening their foothold in the market

Note:Although care has been taken to maintain the highest levels of accuracy in TMRs reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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Tumor Marker Testing Market Size, Growth, Trends and 2023 Forecast Report - OnYourDesks

Im pleading with you please donate blood to help save my baby girl without it shell die – The Sun

A MUM is pleading for people to donate blood - as without blood donors her baby girl would die.

Adeline Davidson, three, has been left the size of a one-year-old after being struck by a rare blood cancer that causes bruising and tiredness.

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And now her mum Steph, 25, is sharing her story in the hopes that more people will donate blood - which will keep children like Adeline alive.

She said: "I felt that sharing Adelines journey would encourage more people to register to become a stem cell donor or to donate blood.

"After seeing a little child go through this, anyone with a good heart would want to help."

Former medical administrator Steph and her husband Jordan, 27, from Alness in Scotland, welcomed their daughter Adeline in November 2016 but her birth was marred by a bowel obstruction which required surgery.

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Adeline recovered well but Steph noticed that she was always small for her age, and at the age of one she was wearing clothes aged up to six months old.

In 2018, Steph made an appointment to see a paediatrician but the four-month wait delayed this until February 5, 2019.

The paediatrician noted how pale Adeline looked and decided to do some blood tests.

Steph said: "Adeline struggled putting on weight and going up a clothes size, so at one she was still in size three to six months.

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"Now, at almost three years old she wears 12 to 18 months.

"I had been complaining about her weight and height for a while, but I eventually got an appointment with a paediatrician and had to wait four months.

"She hadnt put weight on for 18 months and was much smaller than other kids her age.

"I always put it down to her bowel problems from birth, but little did we know there was something else unusual with Ads.

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"The paediatrician wasnt that interested and said she appeared fine, just slightly pale. He took blood tests to check her iron levels."

Just a few hours after Adeline's blood tests Steph received a call asking her to come back in immediately - as the tests showed possible blood cancer.

Steph and Jordan were told to prepare for the worst and the fact Adeline may not ever be able to come home.

I was looking at Adeline, who to me was a healthy, happy, beautiful girl, but they were telling me she was seriously ill it didnt make sense

Steph said: "A few hours later I got a phone call asking to take Adeline in for results.

"I hesitate because it was a long way to go, so he told me over the phone that her bloods indicated a serious problem possibly blood cancer.

"He told us to prepare for not coming home. My heart just stopped, I couldnt believe it and I was hysterical.

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"I was looking at Adeline, who to me was a healthy, happy, beautiful girl, but they were telling me she was seriously ill it didnt make sense."

Initially, doctors suspected leukaemia but when Adeline was transferred to Aberdeen Hospital, further tests confirmed that it wasnt leukaemia, but doctors were no closer to a diagnosis.

Adeline was tested for chromosome mutations, genetic conditions, other types of cancer and doctors are now testing her genomes to find a diagnosis.

Steph added: "There are hundreds of conditions shes been tested for and not one has she tested positive for.

The genome testing theyre doing now consists of putting her DNA sequencing into a pool of other undiagnosed or rare diagnoses and looking for any similarities among them."

Adeline has very low platelets, red blood cell and white blood cell counts, causing bruises, petechia, tiredness, breathlessness and paleness.

In March, doctors believed Adeline could have myelodysplasia, a blood cancer and bone marrow failure, but she shows signs which extend beyond this diagnosis, although it hasnt been confirmed or ruled out.

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While searching for a stem cell match, Adelines blood tests have been reviewed internationally, in Canada and Germany among other countries, to widen the search.

Adeline needs a bone marrow transplant to save her life, but no full matches have been found yet so blood transfusions keep her stable until a match is found.

Low blood counts put Adeline at risk of infection, internal bruising and bleeding out through a small cut as her blood cannot clot as usual.

And since her diagnosis, Adeline has had to be pulled out of nursery for fears of infection or falling which would have devastating impacts on her weakened system.

However, Steph insists that her battle with this mystery illness hasnt dimmed Adelines spirits as she maintains her lively personality and refuses to stop having fun.

What is myelodysplasia?

Myelodysplasia is a type of rare blood cancer where you don't have enough healthy blood cells.

It's also known as Myelodysplastic syndromes (MDS).

There are many different types of MDS. Some types can stay mild for years and others are more serious.

MDS can affect people of any age, but is most common in adults aged 70 to 80 years.

Normally, the spongy tissue found inside bones (bone marrow) produces:

But in MDS, your bone marrow doesn't make enough of these healthy blood cells. Instead, it makes abnormal cells that aren't fully developed (immature).

As the condition develops, your bone marrow gets gradually taken over by the immature blood cells, which don't work properly.

They squeeze out the healthy ones, making the number of cells that manage to get into the bloodstream lower and lower.

The condition can develop slowly (indolent) or quickly (aggressive), and in some people it can develop into a type of leukaemia calledacute myeloid leukaemia (AML).

Source: NHS

She said: "It was planned that Adeline would have a Hickman line put in to allow blood to be taken, transfusions to be given, and any medicine can go through the lines too.

"This was the best news because it was becoming traumatic for Ads as each time she had to get bloods taken, it took five attempts.

"Her veins were so weak and small, so theyd often collapse or move when the needle went in.

"She was an absolute star during the operation and calls her lines her toggles.

"Shes not phased in the slightest with this new accessory.

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"The first diagnosis we got was myelodysplasia in March, a form of blood cancer and bone marrow failure.

"For the last few months, theyve started to steer away from this diagnosis as Adeline has moments of stability and symptoms which arent covered by that diagnosis.

"It hasnt been ruled out, but it could be something else.

"Adelines bone marrow doesnt produce enough red blood cells, platelets or white blood cells so she needs transfusions once every two weeks.

"When she needs platelets, she bruises easily and has little patches of petechia (red or purple spots) on her body.

"When she needs red blood cells, she becomes pale, tired, clumsy and breathless.

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"Platelets help our blood clot when we bruise or cut ourselves, so when Adelines are low, she has a high risk of bleeding out through a cut or bleeding internally from bruising.

"White blood cells help fight infection, so when Adelines are low, she has a high risk of getting an infection and her body struggles to fight it off.

"Even though Adeline is poorly, you wouldnt be able to tell. Shes a lovely, lively, funny, beautiful little girl and this illness hasnt stopped her having fun."

Steph is hoping encourage more people to donate blood or become stem cell donors and has already seen almost 3000 more donors sign up and help save her daughters life.

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TWO MIRACLES I refused chemo & beat cancerthen got pregnant after docs said I'm infertile

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HEART SHATTERING My son has brain cancer after we thought he had blocked nose and headache

TOXIC COCKTAIL Warning as 100,000 people in US get cancer from chemicals in drinking water

'SHE'S AT PEACE' Cancer blogger, 23, dies two years after being diagnosed with rare tumour

KIN'S WIN Ten women from one family are celebrating after they ALL beat breast cancer

FINAL BELL Hospital removes 'cruel' bell rang by patients at end of their cancer treatment

A MUM'S LOVE My baby needed a liver transplant to cure her cancer - I didn't think twice

LIFE SAVINGS We've spent our life savings on hospital parking while our girl fights cancer

She added: "Through all our awareness and fundraising, we are close to 3000 new donors signing up and many have donated blood to help Adeline.

"Peoples donations keep Adeline stable, and they can save so many other lives too.

"Thank you to everyone who is registered and to all those who have donated, you are keeping our daughter alive."

To see more about Adelines journey, visitwww.instagram.com/adelinebluesjourney_x

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Im pleading with you please donate blood to help save my baby girl without it shell die - The Sun

Cell Harvesting Systems Market research to Exhibit Significant Incremental Dollar Opportunity During the Forecast Period 2016-2026 – Analytics News

Cell harvesting is a technique of collecting stem cells for regenerate, transplant or repair the damaged organ with healthy functioning ones.Cell harvestingis considered as an important step in biopharmaceutical manufacturing industry that can directly affect the product quality and related downstream processes. Stem cells harvesting helps in treating with diseases namely cancers, blood disorders, immune deficiency diseases and various injuries. This therapy is also beneficial for burn victims which help them in grafting new skin cells as a replacement for damaged ones.

Many companies are focusing on regeneration of myocardial tissue by injection of cell graft consist of adult stem cells from the patients for manufacturing regenerating medicines. For the treatment of eye diseases new healthy cells are also be grown. For harvesting bone marrow a companies are manufacturing devices with passive flexible drilling unit and suction mechanism which will help in reducing the invasiveness of bone marrow transplantation.Cell harvesting systemhelps in reducing the invasiveness of bone marrow aspiration from the iliac bone with less punctures. Moreover, helps in reducing procedure time and contamination by T-cells.

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Cell Harvesting Systems Market:Drivers and Restraints : Cell Harvesting Systems Market are witnessing maximum growth owing to increase bone marrow transplantation procedures attributed to high prevalence of blood cancer and anemia. Moreover, improving healthcare expenditure, survival rate after treatment, increasing investment in logistic services, expansion bone marrow transplant registry for heart along with neuronal disorders and growing per capita healthcare expenditure. However, high cost of cumbersome treatment, lack of reimbursement policies, immunological rejection, viable cell density, and identification of stem cells in adult tissues, and complications during cell harvesting and inadequate number of HSCs cells for transplantation is a major barrier to the cell harvesting systems market.

Cell Harvesting Systems Market:Segmentation : The cell harvesting systems market has been classified on the basis of techniques, application and end user. Based on techniques, the cell harvesting systems market is segmented into the following: Altered Nuclear Transfer, Blastomere Extraction Based on application, the cell harvesting systems market is segmented into the following: Bone Marrow, Peripheral Blood, Umbilical Cord Blood, Adipose Tissue, Based on end-user, the cell harvesting systems market is segmented into the following: Research Centers, Academics Institutes, Diagnostic Labs, Hospitals

Cell Harvesting Systems Market:Overview :Cell harvesting systems market witnessed substantial growth owing to equipment efficacy and accuracy during stem cells harvest. By application type, bone marrow aspiration is anticipated to hold the major share in the cell harvesting systems market owing to less process error, safe and simple procedure and less side effects. People suffering from Leukemia eligible for bone marrow transplant, is expected to contribute highest share in the global cell harvesting systems market. Cell harvesting systems helps in enhancing proper pigmentation in scar reconstruction which encourage companies for continuous technology advancement in both cell isolation techniques and downstream purification processes.

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Cell Harvesting Systems Market: Region-wise Outlook : Depending on geographic region, cell harvesting systems marketis segmented into seven key regions: North America, Latin America, Eastern Europe, Western Europe, Asia Pacific, Japan, and Middle East & Africa. Asia Pacific dominates the cell harvesting systems marketfollowed by Europe, Japan and North America owing to high concentration of bone marrow stem cells harvesting centers and registries along with skilled doctors for the process of harvesting stem cells in these regions. Asia Pacific, Middle East and Africa hold huge potential and shows substantial growth in terms of wide acceptance of new technologyowing to awareness among population, increasing healthcare expenditure along with high number of potential candidate for the procedure.

Cell Harvesting Systems Market:Key Players :Key players of cell harvesting systems market are PerkinElmer Inc. Tomtec, Bertin Technologies, TERUMO BCT, INC., hynoDent AG, Avita Medical, Argos Technologies, Inc., SP Scienceware, Teleflex Incorporated., Arthrex, Inc., Thomas Scientific, BRAND GMBH

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Cell Harvesting Systems Market research to Exhibit Significant Incremental Dollar Opportunity During the Forecast Period 2016-2026 - Analytics News