PPF Expands its Investment in the Healthcare Sector Through Acquisition of Significant Stake in T Cell Therapy Company Autolus Therapeutics – b3c…

PRAGUE, Czech Republic, September 16, 2019 / B3C newswire / -- PPF today announces the acquisition of a 19.2% stake in Autolus Therapeutics plc, a leader in next-generation T cell programming technologies. The shares were acquired in the market through NASDAQ.

Autolus Therapeutics plc (Autolus) is a leader in T cell programming technologies and is developing a pipeline of next generation T cell therapies targeting both hematological cancers and solid tumors. Focused on the development of precisely targeted, controlled and highly active CAR-T cell products, Autolus aims to provide T cell therapies with very favorable safety profile and enhanced clinical efficacy to better recognize cancer cells, break down their defense mechanisms, and attack and kill these cells. The lead program AUTO1 is expected to enter a pivotal phase II study in patients with adult relapsed or refractory acute B lymphocytic leukemia (adult ALL) later this year with an anticipated filing for marketing authorization in 2021.

With the investment into Autolus, PPF Group N.V. (PPF) significantly increased its commitment to the healthcare sector. Next to Autolus, PPFs majority-owned biotechnology company SOTIO a.s. (SOTIO) is aiming to become a fully-integrated oncology specialty pharma company. Together with SOTIO, PPF have built a biotechnology portfolio through in-house research and development, investments, acquisitions and in licensing of products with companies like NBE-Therapeutics, Cellestia Biotech, Cytune Pharma or Lead Discovery Center. SOTIO is developing its proprietary dendritic cell-based cell therapy platform DCVAC and has a significant manufacturing and regulatory expertise in the domain of cellular therapies. SOTIO also recently initiated a Phase I/Ib clinical trial with its interleukin-15 superagonist SO-C101.

We are very excited by our investment into Autolus. The data published by Autolus on their CAR-T programs is very promising and their long-term ambitions are a perfect match with PPFs strategy in healthcare, said Ladislav Bartonicek, shareholder of PPF responsible for the biotechnology sector. Our investment in Autolus confirms the long term commitment of PPF and SOTIO to build a strong biotechnology portfolio developing a broad range of its own oncology products and investing in various biotech companies with promising new therapies.

About PPF PPF invests in multiple market segments such as banking and financial services, telecommunications, real estate, mechanical engineering, biotechnology, and insurance. PPF Groups reach spans from Europe to the USA and across Asia, owning assets worth over EUR 45 billion (as at 31 December 2018).As at 31 December 2018, PPF Group employed 158,000 people globally, while its companies based in the Czech Republic employed almost 14,000.

About SOTIOSOTIO is an international biotechnology company leading the efforts of PPF Group to build a diverse biotechnology portfolio through its own research & development, collaborations, in-licensing, investments, mergers and acquisitions. The company is developing new medical therapies, focusing on the treatment of cancer and autoimmune diseases. The most advanced project is the SOTIO proprietary platform of active cellular immunotherapy (ACI) based on dendritic cells. SOTIO is conducting multiple Phase I to Phase III clinical trials verifying the safety and efficacy of its DCVAC products. SOTIO is also collaborating with NBE-Therapeutics on the development of novel antibody-drug conjugate products (ADC), with Cytune Pharma on developing novel IL15-based immunotherapies for the treatment of cancer and with LDC and the Max Planck Society on an oncology program addressing a novel target in tumor metabolism. SOTIO has facilities in Europe, the United States, China and Russia. SOTIO is a registered trademark of SOTIO a.s. in selected countries.

Contacts

Jitka TkadlecovSpokeswoman for PPF GroupT +420224174410M +420725 461 574This email address is being protected from spambots. You need JavaScript enabled to view it.www.ppf.eu

Richard KapsaHead of Communication for SOTIOT +420224174448M +420603 280 971This email address is being protected from spambots. You need JavaScript enabled to view it. http://www.sotio.com

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Unproven stem cell treatments provide expensive last resort in families’ search for hope – ABC News

Updated September 18, 2019 06:37:06

It is a quiet Monday morning, and as people are returning to desks and lining up for coffee, Doreen Deede is zig-zagging between bars, collecting cans and bottles emptied over the weekend.

Cashing in refundable containers, hosting charity events, even selling donuts at a local market Ms Deede tried all options as she inched towards a fundraising goal of $35,000 to fund overseas medical treatment.

"For the past nine years I've been Emma's sole carer," she said.

"I call myself her fundraising manager because that's what I've been doing."

Emma, aged nine, suffered a brain injury at birth and has been living with cerebral palsy and dystonia a condition where her muscles contract uncontrollably.

Ms Deede's social life all but vanished as her daughter grew up and significant problems with her mobility, eating, and speech began to register.

"That's when I decided that I wanted to be a mum that gives everything to my daughter," she said.

"The choice included that I live for her, that I do everything in my power to give her all the chances that she can get to one day live independently."

This week, the small family will take another of those chances when they travel from Cairns to the United States for a stem cell treatment to be administered to Emma via two lumbar punctures.

Even with Ms Deede's exhaustive fundraising regime the procedure is so expensive she has had to take out a bank loan and then there is the fact that the procedure has not been clinically proven.

"Everyone that is a parent will know that you do everything for your child," Ms Deede said.

"I would feel guilty if I don't try."

In Australia, the only stem cell treatments classed by the Therapeutic Goods Administration as safe and effective have a narrow application. They generally involve the use of umbilical cord blood or bone marrow to treat disorders of the blood or immune system.

These treatments rely on the function of stem cells, which are unallocated, to replace cells that may be lost or damaged.

Also seizing on that potential has been a burgeoning market of private clinics offering solutions to disorders broadly ranging from neurological conditions to ageing.

As the deputy director of the University of Melbourne's Centre for Stem Cell Systems, part of Megan Munsie's job has been to help inquisitive families understand the sometimes significant gap between what these clinics offered and what was actually sold.

"One of my biggest challenges in this field is the fact that stem cells are somehow seen as magical," she said.

"It's an example of non-evidence-based practice that's gone mainstream."

Ten years ago, this practice sometimes termed stem cell tourism was confined to a handful of clinics in exotic locations.

Since then Dr Munsie has witnessed growth in the number of clinics offering these treatments around the world.

In some cases, they may have been supported only by effusive patient testimonies or materials that blurred the line between medical science and marketing sometimes at the expense of communicating that these procedures were invasive and potentially harmful.

"Our responsibility as a research community is to try to contextualise the science and paint a clearer picture about where exactly we are," Dr Munsie said.

"Unfortunately that means that most of those conversations start with a disclaimer that we don't have any proven treatments for that condition."

On the other side of the equation were families like Ms Deede's, buoyed by hope and leaving no stone unturned.

Success stories may add to the guilt some parents feel.

Even in Cairns, another local family has credited two rounds of treatment with helping their son, who also lives with cerebral palsy, learn to speak and improve his fine motor skills.

"What we do know is there's certainly a lot of promise in this area, but we do still need more data to answer some of the many questions that remain," said Megan Finch-Edmondson, a stem cell researcher with the Cerebral Palsy Alliance Research Institute.

"It's a very interesting and complex question."

Like Dr Munsie, Dr Finch-Edmondson has been in frequent contact with families keen to explore their options.

An Australian-first trial conducted by Melbourne's Murdoch Children's Research Institute has been investigating the use of umbilical cord blood to treat cerebral palsy.

Even though it was only a trial and the selection criteria was rigorous, the limited spaces were highly coveted.

"That is one of the reasons that we are so committed to trying to progress this research and conduct more rigorous clinical trials in Australia," Dr Finch-Edmondson said.

"We do need to operate within [rigorous regulatory guidelines] to get any new therapy, or treatment that's like a drug, approved for use in Australia.

"It does require those very rigorous trials that can show enough data to those regulatory bodies to warrant that this treatment should be available."

Until then, families hamstrung between a long regulatory process and the promises of unproven treatments may continue to take the leap.

"I'm doing it because I love my daughter and I want to give her the best life and the best chance of improvement," Ms Deede said.

"I don't want to be in a situation where I haven't done everything I could and in 10 years' time I might be thinking 'What if?'."

Topics:medical-sciences,health-policy,medical-procedures,healthcare-facilities,medical-research,cerebral-palsy,stem-cells,cairns-4870,university-of-melbourne-3010,melbourne-3000,united-states

First posted September 18, 2019 06:34:23

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American CryoStem Announces: FDA Accepted its Investigational New Drug Application for Post Concussion Syndrome – Yahoo Finance

ATCell Expanded Autologous, Adipose-Derived Mesenchymal Stem Cells Deployed via Intravenous Infusion for the Treatment of Post Concussion Syndrome (PCS) in Retired Military and Athletes

EATONTOWN, NJ / ACCESSWIRE / September 18, 2019 / American CryoStem Corporation (OTC PINK:CRYO) a leading strategic developer, marketer and global licensor of patented adipose tissue-based cellular products and technologies for the Regenerative and Personalized Medicine industries, announced today that it has submitted its first Investigational New Drug Application application for its ATCell product (the "Investigational Drug"), to the U.S. Food and Drug Administration (FDA).

The FDA's acceptance for review of American CryoStem's IND application is a significant milestone for the Company and represents a meaningful step forward in the treatment of patients suffering from Post Concussion Syndrome ("PCS"), and for the advancement of Regenerative Medicine. We are now one step closer to obtaining approval to treat patients with a cellular therapy derived from the patient's own adipose tissue. ATCell, autologous adipose-derived mesenchymal stem cells, is positioned to be a valid therapeutic modality to treat PCS, offering a cellular therapy option to patients not responding to the current standard of medical care.

ATCell is a stem cell product derived from the patient's adipose tissue with biomarker identification through flow cytometry consistently in excess of 97% and is genetically matched to its recipient. The Company's scalable, centralized laboratory model and patented Collect-Process-Store-Return to Point-of-Care Foundational Platform is a best in class end-to-end solution for cellular therapy development and treatment delivery. Through a single adipose-tissue harvest, the Company's laboratory model can create multiple cellular treatments to address various indications and deliver multiple treatments of the patients own genetically matched cells over time affording clinicians the opportunity to pre-plan treatments for their patients.

ATCell samples have been designed to be delivered to physicians, "on demand and ready to use" without complicated and time consuming preparation at the point-of care. Access to the Company's end-to-end, cGMP centralized laboratory processing model and standardized cell manufacturing platform allows physicians, researchers, and collaborators the opportunity to develop new cellular applications and products without the expense of operating a GNP laboratory. This methodology can reduce the development delays and requirements to re-discover and re-create the necessary processing technology (Collect-Process-Store) necessary for the development of new therapies for each specific medical indication.

The Company's Phase I Clinical Trial, upon FDA approval, will investigate ATCell to provide assessments of the safety and tolerability, and to collect clinical data regarding the alleviation of symptoms associated with Post-Concussion Syndrome (IDC-10-CM:F07.81).

Following initiation of the Trial, the Company intends to make ATCell available to collaborators and partners for the development of additional treatment protocols for neurological disorders, muscle-skeletal disease and injury, and tissue repair, among others. Strategically, by rapidly seeking and obtaining approved uses of ATCell, the Company can position itself to become a leader in the development and delivery of treatments into global cellular therapy markets.

Using ATCell, with its high cellular purity and cellular consistency can be an effective treatment of diseases and conditions where there is significant unmet medical need, such as Post Concussion Syndrome. The data generated from this initial study will be used in support of the Company's ongoing efforts to secure regulatory approvals for its patented product for a wide range of medical indications domestically and through its licensed affiliates in China, Japan, Hong Kong and Thailand.

The Phase I Clinical Trial study is designed as a single-site, double-blinded, placebo-controlled study. Each subject will receive either a single infusion of their ATCells or a placebo. Each ATCell cell line will be created from adipose tissue collected by liposuction, and each treated subject will only receive their own cells.

Story continues

Following successful recruitment, each subject will be required to undergo a mini liposuction procedure to obtain the raw material- adipose tissue (AT) for processing, testing and preparation of their autologous treatment. Following administration, each subject participant will be followed for six months for evaluation and safety monitoring at designated intervals of one day, one week, and one, three and six months.

ATCell is defined as expanded autologous adipose-derived mesenchymal stem cells having the following identification through flow cytometry analysis:

1. Positive expression of the phenotypic marker antigens CD13, CD29, and CD44

2. Negative expression of the phenotypic marker antigens CD31, CD34, and CD45

During development of the ATCell treatment product, the Company will confirm that these cells are plastic adherent and capable of tri-lineage differentiation.

Post-Concussion Syndrome (PCS) is a set of symptoms that may continue for weeks, months, a year or more after a concussion. Any individual with a history of even a single concussion may develop persistent symptoms associated with the injury.

Overall, the estimated cost of traumatic brain injuries (TBI) in the United States weighs in at $48.3 billion annually of that $31.7 billion is spent on hospitalization costs, while the additional $16.6 billion is attributed to costs associated with fatalities. According to the Center for Disease Control, acute care and rehabilitation of brain injury patients in the United States cost about $9 - $10 billion per year. This does not include indirect costs to society, and families, associated with lost earnings, work time, and productivity, as well as expenditures linked to social services. https://www.brainandspinalcord.org/cost-traumatic-brain-injury/.

The Company recognizes the significant market opportunity for its new autologous cellular therapy modality for the treatment of Post Concussion Syndrome and mild Traumatic Brain Injury via infusion therapy of Autologous Expanded Adipose-Derived Mesenchymal Cells. The Company intends to leverage its early clinical study using this delivery protocol for the treatment of other diseases and muscle-skeletal disease and injuries with significant multibillion dollar therapy markets.

CRYO's GMP laboratory platform serves to accelerate physician and patient adoption of cellular therapeutics as new and effective treatment protocols. Stringent manufacturing protocols include triple sterility checks, high cell viability, potency and proliferation manufacturing is unmatched in the industry.

American CryoStem is looking forward to harnessing the power of its autologous stem cell platform technology to transform the lives of people with substantial serious diseases and address unmet medical needs around the world.

For further detailed Corporate or Regenerative Medicine information please visit:www.americancryostem.com, request by email at info@americancryostem.com or

phone 732-747-1007

This press release may contain forward-looking statements, including information about management's view of American CryoStem Corporation's ("the Company") future expectations, plans and prospects. In particular, when used in the preceding discussion, the words "believes," "expects," "intends," "plans," "anticipates," or "may," and similar conditional expressions are intended to identify forward-looking statements. Any statements made in this press release other than those of historical fact, about an action, event or development, are forward-looking statements. These statements involve known and unknown risks, uncertainties and other factors, which may cause the results of the Company, its subsidiaries and concepts to be materially different than those expressed or implied in such statements. Unknown or unpredictable factors also could have material adverse effects on the Company's future results. The forward-looking statements included in this press release are made only as of the date hereof. The Company cannot guarantee future results, levels of activity, performance or achievements. Accordingly, you should not place undue reliance on these forward-looking statements. Finally, the Company undertakes no obligation to update these statements after the date of this release, except as required by law, and also takes no obligation to update or correct information prepared by third parties that are not paid for by American CryoStem Corporation.

SOURCE: American CryoStem Corporation

View source version on accesswire.com: https://www.accesswire.com/560118/American-CryoStem-Announces-FDA-Accepted-its-Investigational-New-Drug-Application-for-Post-Concussion-Syndrome

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American CryoStem Announces: FDA Accepted its Investigational New Drug Application for Post Concussion Syndrome - Yahoo Finance

The global platelet-rich plasma market is expected to register a CAGR of approximately 14% – Yahoo Finance

NEW YORK, Sept. 11, 2019 /PRNewswire/ --

Market OverviewThe global platelet-rich plasma market is expected to register a CAGR of approximately 14% over the forecast period. The key factors that are augmenting the growth of the market include rising incidences of sports injuries, increasing number of androgenic alopecia patients, growing use of platelet-rich plasma in various therapeutic areas, and rise in the prevalence of arthritis.

Read the full report: https://www.reportlinker.com/p05815089/?utm_source=PRN

Osteoarthritis (OA) is the most common form of chronic disorder of the joints, and it has some detrimental effects on the quality of life of the patients. Progressive cartilage destruction, osteophyte formation, and subchondral sclerosis are characteristic to osteoarthritis. Platelet-rich plasma (PRP) is an autologous concentration of a high number of platelets in a small volume of plasma. PRP is prepared to centrifuge blood. In knee OA, PRP injections target to promote cartilage repair in order to relieve symptoms of osteoarthritis, hence delaying the need for joint replacement surgery.

The rising prevalence of the arthritis is augmenting the demand of the blood products, which is ultimately helping the growth of the platelet-rich plasma market.

Scope of the ReportAs per the scope of the report, platelet-rich plasma (PRP) prolotherapy, like dextrose prolotherapy, is a method of injection designed to stimulate healing. Platelet-rich plasma is defined as autologous blood with concentrations of platelets above baseline levels, which contains at least seven growth factors.

Key Market TrendsPure PRP Segment by Type is Expected to Hold the Largest Market Share

The pure PRP segment of the global platelet rich plasma market is believed to have the largest market share.

The prime factor responsible for the growth of this segment is the significance of this type of platelet plasma for the person. Pure PRP has an edge over traditional PRP, as it requires a two-step concentration process that helps in eliminating unwanted red blood cells (RBCs) and neutrophils. RBCs (that have no therapeutic effects for regeneration) can create a more viscous solution that can be more painful when injected. Neutrophils, a type of white blood cell, have inflammatory components that may increase pain and inflammation post-treatment.

Pure PRP helps the stem cells and regenerative cells in the repair and in rebuilding the damaged tissue. This ultimately speeds up the healing process and reduces pain. In addition, it promotes increased strength and improves the overall function. Therefore, owing to the contribution of pure PRP in the healing process and the rising use of it as a blood product, the segment is expected to dominate the market in the coming future.

North America Dominates the Market and is Expected to Continue the Same Trend for Next Few Years

North America currently dominates the platelet-rich plasma market and is expected to continue its stronghold for a few more years. The United States is a major market, and this is mainly due to the US government's initiatives to develop blood products. In addition, the emergence and adoption of novel technologies are going to help the market in a positive manner.

Competitive LandscapeCompanies, such as Biotest AG, China Biologic Products Inc., CSL Ltd, Octapharma AG, and LFB SA, are some of the key players operating in the global platelet-rich plasma market. With the advancement in technology, new players are expected to come in the market.

Reasons to Purchase this report:- The market estimate (ME) sheet in Excel format- Report customization as per the client's requirements- 3 months of analyst support

Read the full report: https://www.reportlinker.com/p05815089/?utm_source=PRN

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Revolutionary Cosmetic Skin and Sexual Wellness Treatments Are Coming to Central New Jersey – P&T Community

EAST BRUNSWICK, N.J., Sept. 17, 2019 /PRNewswire/ -- Botox, dermal fillers, and sexual wellness treatments are among the new aesthetic treatment procedures available at IVIV Health and Aesthetics, a medical aesthetic practice located in the heart of central New Jersey.

IVIV Health and Aesthetics is owned and operated by Dr. Tanya Weissman, a board-certified physician with extensive experience working with PRP treatments, stem cell treatments, and Botox injections to help manage chronic pain and heal damaged tissues and tendons. Weissman was named by NJ TopDocs as a 2019 Top Doctor.

"We take a physician-first approach at IVIV Health and Aesthetics because we want our patients to know that their health and safety is our priority," Weissman said. "Patients feel reassured by our use of nurses and nurse practitioners, who are fully trained in the protocol required for these treatments, including drawing blood and injection safety."

This makes IVIV Health and Aesthetics one of very few establishments that offer such a variety of wellness services and most importantly have an experienced medical professional to ensure they are administered in a safe and comfortable fashion.

Weissman is joined by Dr. Aleksandra Novik, a nurse practitioner who brings experience in aesthetics, cardiology, endocrinology and physical medicine and rehabilitation to IVIV Health and Aesthetics.

"Dr. Novik takes pride in making sure patients feel their best and achieve natural-looking results," Weissman said. "We are thrilled to welcome her to the IVIV Health and Aesthetics family."

According to Weissman, adding Botox injections to the practice enables her and Novik to treat medical conditions as well as cosmetic treatments. Botox is a common treatment for hyperhidrosis (excessive sweating), migraines, and TMJ, as well as for cosmetic enhancement such as fine lines, wrinkles, and crow's feet.

"These injections can be a very effective treatment for patients seeking to control excessing sweating in the palms, feet, and underarms," Weissman said.

According to Weissman, many treatments at IVIV Health and Aesthetics, particularly platelet-rich plasma (PRP) aesthetic treatments, are designed to support and enhance the body's natural healing power. The sexual wellness treatments added to the medical spa's lineup of services use PRP rejuvenation to increase blood flow to the genital area in both men and women, which helps with performance, sensitivity, and satisfaction.

"With regenerative treatments, the body uses its own resources to heal itself by enhancing its natural healing processes," Weissman said. "Whenever the body detects injury, platelets rush to the site to help facilitate the healing process. Platelet-rich plasma is full of those same growth factors that enable your body to regenerate using its own characteristics, making it an excellent option for acne scarring and reviving skin for a youthful, refreshed look."

Botox, dermal fillers and sexual wellness treatments join the medical spa's lineup of physician-administered aesthetic treatments, including PRP treatment for hair restoration and regrowth, PRP treatment for face and skin, vitamin drips, and IV therapy. For more information or to book an appointment, visit http://www.IVIVHealth.com.

ABOUT IVIV HEALTH AND AESTHETICS

Based in the heart of central New Jersey, IVIV Health and Aesthetics offers rejuvenation treatments in a safe and relaxing atmosphere. Under the care and guidance of a doctor and nurse practitioners, clients can receive treatments such as Juvderm, Botox, platelet-rich plasma (PRP) treatments for hair and skin rejuvenation, IV drip and vitamin therapy, and PRP-based sexual wellness treatments. For more information or to book an appointment, visit http://www.IVIVHealth.com.

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Kourtney Kardashian Just Got PRP to Fix a Bald Spot – NewBeauty Magazine

Many of us have differing opinions on all things Kardashian, but one thing we can probably agree on is that we love their candidness about beauty problems and beauty treatments. And in the Season 17 premiere of Keeping Up With the Kardashians Sunday night, we got a major dose of just that.

You May Also Like: The Buzzed-About Treatment Kim Kardashian West Regrets Getting

As Kim was casually chatting with Kourtney, she spotted a bald patch on the top of Kourtney's head and immediately freaked out. Kourtney, you have a really big spot on the top of your head, Kim said. Look down, Kourtney. Oh my god, Im afraid for your life. Have you seen that? Kourtney responded, No, but I feel it, and attributed it to the sky-high (and apparently incredibly tight) ponytail she had worn at a recentgala. Its a hole in my head.I swear its from my ponytailit was so tight that I had a bump on my head like this [she used her hand to demonstrate a big bump].

Crazy enough, that canactually happen. This is called traction alopecia, which is a type of hair loss resulting from a constant pulling force being applied to the hair," says Beverly Hills, CA facial plastic surgeon and hair restoration specialist Natalie Attenello, MD. "This is commonly seen in people who consistently wear tight ponytails, pigtails or braids."

To fill in the bald area, Kourtney opted for platelet-rich plasma (PRP) injections, which is becoming an increasingly popular nonsurgical treatment for thinning hair and hair loss. Today Im getting PRP, which is where they take your blood and spin it and they use your plasma and they inject it in my head for my hair to grow back, she said on the show at a visit to her doctor, who assured her it could take a while for the hair to grow back.

You May Also Like: 5 Expert-Recommended Hair Loss Treatments

For those interested in PRP for hair loss, New York facial plastic surgeon Jennifer Levine, MD recommends three treatments spaced a month apart. "Usually you can see some difference after the second treatment, but it may take six months to experience the full effect." Dr. Attenello adds, "If there is a minimal improvement seen, a more definitive option of a hair transplant may be considered."

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Kourtney Kardashian Just Got PRP to Fix a Bald Spot - NewBeauty Magazine

Kourtney Kardashian Got Scalp Injections to Treat a Bald Spot – Glamour

Ever since she figured out how to manage her relationship with Scott Disick, Kourtney Kardashian's storylines on Keeping Up With the Kardashians have been relatively drama-free. But during the show's season 17 (!!!) premiere Sunday night, the eldest sister was facing a beauty emergency.

During a scene with Kim, the sisters discuss a not-small bald spot that has formed on the top of Kourt's head. "Kourtney, you have a really big spot on the top of your head, Kim said. Look down, Kourtney. Oh my God, Im afraid for your life. Have you seen that?

No, but I feel it, Kourtney replied. "Its a hole in my head. I swear its from my ponytail, it was so tight that I had a bump on my head like this. Obviously, Kim is being overly dramatic, but the spot is noticeable in the clip below.

"Hair loss is not always genetic in nature," plastic surgeon Steve Fallek, M.D., medical director at BeautyFix Med Spa in New York City, tells Glamour. "Physical and mechanical stress can weaken and even damage the hair follicle, leading to hair loss. Tight ponytails can certainly pull your hair out of the hair follicle and are a common cause of hair loss. Coloring your hair or treating your hair with harsh chemicals can also contribute to this. Weight loss, nutritional changes, medications, as well as stress are other typical factors for hair loss."

Of course, when you're a Kardashian, you have pretty much any beauty treatment available to you at any given moment, so Kourtney heads to see Dr. Jason Diamond later in the episode to address the bald spot with scalp injections. Today Im getting PRP [platelet-rich plasma], which is where they take your blood and spin it and they use your plasma and they inject it in my head for my hair to grow back, she said.

Plasma treatments for conditions like alopecia are becoming more popular, and Kourtney did a pretty good job explaining the basics. Blood is taken from the patient and put into a centrifuge to separate out the plasma that will then be used for the injections. According to the Cleveland Clinic, the plasma "helps repair blood vessels, promote cell growth and wound healing, and stimulate collagen production."

"Given its name, PRP is rich in platelets which have multiple growth factors, which help the hair follicles to grow," Fallek says. "The PRP is then injected into your scalp where there is hair loss. A topical anesthetic is normally applied prior to injections, and the treatment takes about 5 to 10 minutes." He says that treatment is varied but that most doctors will inject areas of alopecia monthly for three months initially and then twice a year for maintenance. You can expect to notice improvement after two to three months.

Here's hoping Kourt gives us a hair-growth update soon.

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Kourtney Kardashian Got Scalp Injections to Treat a Bald Spot - Glamour

Platelet Rich Plasma for hair loss: Does it work? – Global Village space

Platelet-rich plasma (PRP) is a treatment that doctors use to accelerate healing in various areas of the body. It may help restore hair growth.

Doctors typically use this treatment whenhair lossresults fromandrogenetic alopecia, a common condition that causes hair follicles to shrink. In males, this is called male patternbaldness.

AlthoughPRPis a relatively new approach, there is some scientific evidence to suggest that it can promote hair growth. In this article, we describe how doctors use PRP to treat hair loss and what researchers say about its effectiveness.

To understand how PRP works, it is important to be aware of the role that platelets play in healing. Platelets are a component of blood, along with red and white blood cells. When a person sustains a cut or wound, the platelets are some of the bodys first responders that arrive to stop the bleeding and promote healing.

PRP is not a cure for conditions that cause hair loss. For this reason, a person would need to receive multiple PRP treatments over time to maintain hair growth results.

Researchers theorized that if they could extract concentrated platelets and inject them into damaged areas of the body, they could accelerate healing.

To produce PRP, a medical professional will take a blood sample and put it into a machine called a centrifuge. This machine spins at a rapid rate, which separates the components of the blood. The medical professional then extracts the platelets for injection.

PRP contains a range ofgrowth factors and proteinsthat speed tissue repair. As some types of hair loss result from damage to hair follicles, researchers initially hypothesized that PRP could help regrow hair by reversing the process that occurs in androgenetic alopecia.

Since then, PRP has become a popular method of restoring hair growth. Doctors have also used PRP to treat injuries to the tendons, muscles, and ligaments, such as those that people sustain during sporting activities.

Read more: Got thin hair? Find out why!

In 2019, a team of researchers carried out a systematic review of the research on PRP as a treatment for hair loss. Their findings appear in the journalAesthetic Plastic Surgery.

The analysis ultimately focused on 11 research papers that included a total of 262 participants with androgenetic alopecia. According to the authors, most of the studies found that injections of PRP reduced hair loss and increased the diameter of hairs and the density of hair growth.

They acknowledged, however, that the treatment is controversial, noting that small sample sizes and low quality of research were among the limiting factors of their investigation.

Another 2019 systematic review, which featured inDermatologic Surgery, examined the findings of 19 studies investigating PRP as a treatment for hair loss. These studies recruited 460 people in total. According to the authors of the review, most studies reported that PRP treatments led to hair regrowth in those with androgenetic alopecia andalopecia areata.

The authors of an additional review of clinical studies, which theInternational Journal of Womens Dermatologypublished, considered PRP to be a promising treatment for hair loss, based on their findings.

However, the team noted that because various researchers and clinics use different preparations, session intervals, and injection techniques to administer PRP, its effects can vary.

At this point, without a standardized protocol for injections, the authors explain, it is difficult to conclude that the treatment is effective.

The following steps are an example of a common approach to PRP injections for hair loss:

The entire process may take about 1 hour, and several sessions may be necessary. After receiving PRP treatment, a person can usually return to their regular activities without any limitations.

PRP is not a cure for conditions that cause hair loss. For this reason, a person would need to receive multiple PRP treatments over time to maintain hair growth results. The same is true of medications that doctors commonly use to treat androgenetic alopecia, such as topical minoxidil (Regaine) and oral finasteride (Propecia).

The doctors recommendations for how often a person should have PRP will vary depending on a persons condition and the results of their initial treatment. The doctor may suggest having maintenance injections every36 monthsonce hair loss is under control.

Read more: Men and hair loss an unavoidable animosity

Possible side effects include a headache, mild pain at the injection site, and scalp tenderness.

As the PRP solution consists of a persons own blood components, there are few risks of a reaction to the solution itself.

However, people undergoing PRP treatments for hair loss may experience the following side effects:

Researchers have found evidence that PRP can lead to renewed hair growth. However, due to the limitations of these studies such as small sample sizes and the variation in technique and protocol among doctors, further research is necessary to confirm whether PRP is effective.

Doctors and researchers also need to identify the best candidates for PRP and develop universal treatment protocols.

At present, anyone with mild-to-moderate hair loss who is interested in PRP should ask a doctor whether they are likely to benefit from the treatment.

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Platelet Rich Plasma for hair loss: Does it work? - Global Village space

5 Treatments Derms Say You Should Never Buy on Groupon – NewBeauty Magazine

If you want to incite the ire of a group of board-certified dermatologists, say the word Groupon around them. The good stewards of hair, skin and nails do not mince words when it comes to procuring medical treatments on the local discount marketplace. Dont Groupon your face, cautioned Portland dermatologist Gretchen Vanderbeek, MD.

This is the main sentiment expressed by most of the doctors we interviewed, and we agree with their expert opinion, but we wanted to know exactly which procedures are completely off limits or if maintenance treatments like chemical peels, microdermabrasion or laser hair removal are considered ok. Here, the experts weigh-in and sound off on the dangers of bargain cosmetic treatments.

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1.Laser Skin Resurfacing TreatmentsWarwick, RI dermatologist Caroline Chang, MD says I would not use a Groupon for laser treatments. Lasers are high-powered devices that, in the hands of an unqualified medical professional, can cause severe risks such as permanent scarring.

Ontario,Canada dermatologist Dusan Sajic,MDsays laser treatments are definitely on his no-no list: I like to classify absolute no-nos basedon if the treatment can burn or permanently scar, disfigure, cause infection or cause life-threatening problems or organ threatening problems. Anything ablative, whether fractional of not, actually burns and damages the skin in a controlled manner. This includes radio-frequency microneedling and Fraxel and Halo lasers. All lasers and IPLs can cause burns, but these are particularly worrisome. There are also specific skin types like darker skin tones that have amuch higher risk for burns or discoloration. Many of my patients need pre-treatment with specific and very tailored skin care like hydroquinone for preventative measures. Not only are you safer getting this done in a board-certified dermatologist office, but should there be a complication, these are the skin experts you want by your side to treat it. Like with any complication, timing is everything.

Township, MI dermatologist Linda Honet, MD says to never ever use Groupon where theres a needle or powerful device like a laser involved. The best that can happen is that it doesnt work or last, she says. The worst that can happen is that you may have less than desirable results or permanent side effects or complications that are tough to reverse or fix. Dont gamble on your health or cut costs. Seek the care of a knowledgeable, well-trained, skilled core physician like a board-certified dermatologist. Remember that full price means full care. Ask any dermatologist if they would ever do a Groupon cosmetic treatment on themselves, and the answer will be a swift, horrified 'No!

Bannockburn, IL dermatologist Heather Dowes, MD agrees. Burns and scars from lasers and IPL devices are a major cause of lawsuits. The only time Ive seen burns or scars from laser treatments was in patients who were lasered by someone who was NOT a board-certified dermatologist.

2.MicroneedlingGermantown, TN dermatologistPurvisha Patel, MD says to scroll past the micro-injury inducing microneedling offers, too. I would say anything that requires knowledge of anatomy and science, pass on. Especially procedures where blood is involved, from injections to microneedling to lasers. These procedures should be performed in a medical setting where MDs are present. If you can bleed or the skin gets poked, disrupted or starts bleeding, this treatment needs to be done in a medical setting which is likely not the place that places Groupon ads.

Its important to not let yourself be fooled into thinking that a laser or an injectable such as a filler or toxin is not a medical procedure, says New York dermatologist Jennifer Silverman Kitchin, MD, because they most definitely are medical treatments. And they are treatments with real risks. If you are considering any type of invasive medical treatment for your skin, such as lasers, injectables, peels or radio-frequency microneedling, you should see the only true skin expert, a board-certified dermatologist.

3.Laser Hair RemovalOklahoma City, OK dermatologist Kimberly Jerdan, MD says to be wary of the laser hair removal membership offers: I would say no to laser hair removal with a Groupon. Laser hair removal should be tailored to the patients skin type and type of hair, and you never know what kind of laser the facility has, and whether it suits your skin or hair best. Ive seen many burns or permanent scarring this way. Also, when done well with people who understand the science of the wavelengths, one shouldnt have to continue treatment for more than six to nine months. Ive seen many patients get scammed with a monthly laser hair removal fee that theyve been doing for two years! It should be tailored to the patient, not the number of sessions.

4.Platelet-Rich Plasma (PRP) Therapy for Skin and HairOne of the biggest regenerative medicine trends has finally made its way on Groupon and Chantilly, VA dermatologist BrendaDintiman, MD says to stay far, far away from PRP coupon deals: Platelet-Rich Plasma (PRP) has very specific blood collecting tubes to collect and spin to separate the platelets. No shortcuts or substitutions can be made, or the patient is put at risk for infections such as hepatitis B and C and HIV; which has already reportedly happened in a clinic in New Mexico. When the price is so low on a Groupon, you can be sure that they are cutting safety corners and patient safety is not their first priority. There are other ways to save money, but not when it comes to healthcare and cosmetic procedures like PRP for hair loss and microneedling!

Beverly, MA dermatologist Vladimir Ratushny, MD adds: I would avoid any invasive medical procedure advertised on venues such as Groupon. You should always look at the credentials of the individual doing the procedure and select an expert such as a board-certified dermatologist to trust with your skin and hair health. PRP involves drawing up blood and one has to be very careful with any blood products. As a board-certified dermatologist that does hair transplantation, I have the training to ensure patient safety and outcomes.

5.Botox and Fillers"Just say no to injectable treatments," says every single doctor we interviewed, including Washington DC dermatologist Thomas Adrian, MD. Whenever anyone asks me why I dont do Groupons, I tell them that I dont do Groupon Botox, I just fix Groupon Botox.

Dr. Dowes notes, These Groupon offers typically come from med spas who do not employ board-certified dermatologists or plastic surgeons, but rather estheticians, nurses, and other providers who have not been residency- or fellowship-trained in cosmetic dermatology. I spoke to one med spa owner who told me she purchases Botox for her medspa at half price through a reseller who imports it from other countries. This is illegal. And it is impossible to know if the Botox is authentic. Botulinum toxins and fillers can only be LEGALLY purchased at full price through their respective U.S. manufacturers such as Allergan and Galderma. How else could these med spas afford to offer such low Groupon prices for these injections?

Glendale, AZ dermatologist TonyNuara, MD cautions, Most cosmetic injectables carry a National Drug Code (NDC) number. They are prescription medical devices and as such should really only be done by a qualified physician. For the life of me, I still dont understand how it is legal for spas to do this. If they were selling prescription medications, the authorities would be all over it.

Dr. Sajic says a bad result isnt the only reason to avoid injectables on the coupon app. Injection into an artery can cause blindness. It is crucial that one picks a doctor who knows anatomy exquisitely and who goes to conferences very frequently to brush up on it. While this has been mostly reported with fillers, there has been one reported case of platelet-rich plasma causing blindness! Flushing, NY dermatologist Winifred Chu, MD says, If not performed by a board-certified dermatologist or plastic surgeon who are physicians specially trained in facial anatomy, serious complications can occur which includes but not limited to infections or vascular occlusion leading to skin necrosis and blindness.

Know Before You BuyNew Orleans dermatologistMary Lupo, MD said it best when she cautioned, Good cosmetic treatments are not cheap and cheap cosmetic treatments arent good. But there are some reputable doctors who have used the site to get new patients in the door. The good doctors we spoke to said if you really want to Groupon your treatments, research your practitioner and make sure he or she is legit. Rockwall, TX dermatologist Elizabeth BaharHoushmand, MD says, I think asking who is performing the procedure is critical. Is it a board-certified dermatologist or plastic surgeon? Some colleagues offer Groupon to gain new patients, but I personally dont. It is important for the public to do their homework before buying.

Groupon can be perfectly fine for any cosmetic treatment, as long as it is performed by someone with adequate trainingnamely, a board-certified dermatologist, advises Milford, MA dermatologistDennis Porto, MD. The issue is that very few dermatologists use Groupon because we are already very busy with the huge number of patients who seek the care of an expert. Thus, Groupon is often a place for those who are less qualified to find unsuspecting patients seeking a bargain. This isnt always the case, however, so just check to make sure the treating physician is a board-certified dermatologist and you can rest assured. These dermatologists are identified with a 'FAAD' after their name.

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5 Treatments Derms Say You Should Never Buy on Groupon - NewBeauty Magazine

The Ultimate Guide to Thinning Hair – NewBeauty Magazine

This article first appeared in the Fall 2019 issue of NewBeauty. Clickhereto subscribe.

Hair is way more than inanimate protein attachedto our heads. It highlights our personal style, acts as a security blanket and boosts confidence. Theres a reasonhashtag #goodhairday has been used nearly 1.5 milliontimes on Instagram: When someones hair looks good,they want to show it off. But for the millions sufferingfrom hair loss, there may be more bad hair days thangood. Thanks to cutting-edge products, devices and procedures, this doesnt have to be the case.

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WHY HAIR THINSThe average person has about 100,000 hairs ontheir head and loses about 100 of them every day (to thedetriment of shower drains and bathroom floors everywhere). But, if those hairs dont grow back at the same rate,or more than 100 hairs fall out, it may be a sign of thinning.And shockingly, the American Academy of Dermatologycites that a whopping 40 percent of women have visiblehair loss by age 40. The sooner you seek care, the betteryour chances are of successfully treating it, says BeverlyHills, CA hair restoration specialist Dr. Craig Ziering. Butin order to prescribe a treatment, we need to determinethe reason for the thinning. These are the most common:

GeneticsAndrogenic alopecia (AGA), or male and female patternhair loss, is the most common form of hair loss and affects nearly 50 million men and 30 million women in theU.S., according to the National Institutes of Health.Chances are, if sparse strands are common on either sideof your family, you will experience the same. Femalehair thinning shows up in three different ways: enlargingof the center hairline part, frontal hair line recession anda diffuse thinning pattern, says Beverly Hills, CA hairrestoration specialist Natalie H. Attenello, MD.

Although often hereditary and occurring in healthyindividuals, AGA has been associated with serious conditions such as hypertension, diabetes and polycysticovarian syndrome, so see your doctor if you have concerns, says Pittsburgh plastic surgeon Brian V. Heil, MD.

DietIn addition to taking the patients personal and familialhistories into account, doctors often suggest a blood test,which can reveal mineral and vitamin deficiencies thatmay be affecting hair. Low vitamin D and iron can beculprits, and its common to see depleted levels of themthese days, says New York dermatologist Dhaval G. Bhanusali, MD. In those cases, I generally prescribe a dailydose of 5,000 IU vitamin D and an iron supplement. Beverly Hills, CA dermatologist Rhonda Rand, MD saysvegetarians often have less hair because they dont eat asmuch protein. You need 40 grams a day, and most of myvegetarian and vegan patients arent getting that much.

HormonesA key hair loss offender is the DHT hormone (dihydrotestosterone), a derivative of testosterone that binds to receptors in hair follicles on the scalp and shrinks themuntil they can no longer function. Blood work can disclose testosterone levels, and if theyre elevated, medication can balance them out, says Dr. Rand.

Sharp hormone shifts after pregnancy are also commonly tied to hair thinning, although the effects are temporary. Women have some of the thickest hair theyllever have right before they give birth, and then two tofour months post-partum, many of them experiencetelogen effluvium, a dramatic, yet temporary change asthe hair goes into resting phase for two to four monthsand thins out, Dr. Rand explains. Around eight monthsafter childbirth, the hair should be back to normal.

Menopause can stir up hair issues too, as lowerestrogen levels are linked to thinning. Many women losesubstantial amounts of hair after menopause, says Dr.Ziering. Their hair tends to thin out all over, rather thandevelop a signature spot like men do at a similar age.

StressAlopecia areata is a form of sudden hair loss thats oftencaused by stress and shows up in circular bald patches.Its considered an autoimmune disease because the immune system gets stressed and attacks the hair follicles,causing them to weaken and fall out, Dr. Bhanusali says.Theres no cure yet, but Dr. Ziering says it can be treatedsuccessfully with injectable steroidstypically everythree to six weeksthat suppress the immune system.

IllnessAny auto immune disorder could cause hair loss, saysDr. Heil, but its most common with lupus and thyroiddisease due to the alteration of the bodys ability to function normally. Once the disorder is treated and the bodyis in remission, hair growth should return to normal.

MIRACLE GROW:The three stages ofthe hair growth cycle

1. The Anagen Phase (lasts 26 years)Also known as thegrowing stage, thisis when the cellsin the root of eachhair divide, pushingthe previous strandout to make room fora new one. Hairthats in anagen forless than two yearsis usually thinning,says Dr. Rand, andthe length of apersons anagenphase is geneticallypredetermined.

2. The Catagen Phase (lasts 23 weeks) Hair takes a breakfrom growing andprepares to shedso it can eventuallyrenew. This isreferred to as thetransitional phase,during which clubhair (hair that hasstopped growing)begins to form.

3. The Telogen Phase (lasts 3 months) This is the restingphase, during whichclub hair is fullyformedif one ispulled from the root,youll see a hard,white substance onits tip. Dr. Rand saysabout 10 percent ofhair is usually in thetelogen stage.

HOW TO TREAT ITThinning hair isnt a quick-fix conditionoftentimes a multipronged approach withchanges to diet, products and treatments delivers the best results. Some nonsurgicalsolutions are both preventive and effective,providing reasonable improvements," saysDr. Ziering, but its important to have realistic expectations, as results can take monthsto manifest.

Essential OilsWhether theyre applied solo or infused into hair-care products, essentialoils are praised for their stimulating,balancing and calming properties that havebeen shown to spur healthy hair growth.Tea tree and cypress are proven to improvemicro-circulation deep in the scalp and increase blood flow to each follicle, saysFranois Hourcastagnou, CEO of hair-carebrand PHYTO and Als Group, USA. Rosemary can gently but effectively exfoliate thescalp, sage can help calm irritation andlemon oil can balance sebum production sofollicles dont get clogged. According to integrative medicine specialist Dr. Elizabeth Trattner, one study on 84alopecia areata patients revealed that massaging a mix of cedarwood, lavender, thymeand rosemary oils with either jojoba or grapeseed carrier oils into the scalp for sevenmonths produced significant hair growthimprovement in 44 percent of the group,compared to 15 percent of patients who usedjojoba or grape seed alone. Another studyshowed 3 percent peppermint oil appliedtopically helped facilitate hair growth bypromoting circulation in the hair dermalpapilla [cells at the base of hair follicles], sheadds. (Note: Applying essential oils directlyto the scalp could be too strong and cause irritation, which is why most are mixed withcarrier oils. Doing a patch test at the nape ofthe neck to check their compatibility withyour skin is recommended.)

Diet + NutraceuticalsTo strengthen brittle hair, Dr. Attenello says its best to follow a balanced diet that includes protein and foodssuch as eggs, fish and nuts that contain omega-3 fatty acids. We also recommend zinc,iron and biotin supplements, all of whichhave been shown to improve hair texture andcaliber, she adds.Dr. Ziering likes Viviscal, a daily supplement that contains a marine complex calledAminoMar that helps promote existinghealthy hair growth from within, but is notan option for patients with shellfish allergies. Another expert favorite is Nutrafol,which New York plastic surgeon Jennifer Levine, MD says is good for both thinninghair and anti-aging. It neutralizes free radicals, rebalances stress-producing hormones and contains botanicals that promote theabsorption of hair-boosting nutrients, sheadds. With the majority of hair supplements,some users can see results after one month,but experts say three months is standard.

AcupunctureIn Chinese medicine, acupunctureis often used as a remedy. Needlesare placed on the face, body andscalp to promote blood and energy circulation to the scalp, stimulating hair growth,says Dr. Trattner. Studies show it can helptreat female thinning better than male, although reasons for this are undetermined. Aseries of treatments need to be done weeklyor biweekly to restore balance, and thenmaintenance depending on individual results. Some people get better outcomes thanothers, but when combined with Chineseherbal medicine, results are synergistic andalmost always better, Dr. Trattner adds. It isalso important to find a licensed practitionerwho is familiar with hair loss.

Hair CareThinning hair demands extra TLC,so any products used on it shouldhave scalp health and hair growthproperties. Some brands tout biotin as astrand booster, but Dr. Rand says minoxidilknown over-the-counter as Rogaineisthe only FDA-approved OTC ingredient thathas been clinically proven to increase the diameter of the hair follicle, producing thickerhair. Results may take months to exhibit,and side effects associated with topical minoxidil can include scalp itching and flaking,so it's not an option for everyone. For those going the natural route, botanical-based topicals can also be effective:French hair-care brand Ren Furterer formulates with follicle-energizing pfaffia extract (aka Brazilian ginseng) and sebumreducing curbicia (a patented extract fromsquash seeds) to promote growth. No matter the product used, Dr. Rand notes:If you stop using it, the results will stop too.

Product Picks: Ren Furterer Triphasic Strengthening Shampoo ($32); PHYTO Phytopolline Botanical Scalp Treatment ($40); Nutrafol Core for Women ($79); Viviscal Advanced Hair Health Supplements ($50).

However, a new platform called HairStim is now being offered by dermatologists around the country, who can customize products to include a mix of prescription-strength ingredients such as topical finasteride and spironolactone, depending on the patients concerns. Weve seen impressive results so far on both men and women, Dr. Bhanusali says.

Oral finasteride (you may know it by its brand name Propecia) is commonly prescribed in a 1 milligram dosage for men, and sometimes for post-menopausal women as well"its not advised for childbearing women because of its hormone interference, says Dr. Attenello. This also applies to oral spironolactone. A double-blind study in 2014 revealed that 400-milligram capsules of pumpkin seed oil could mimic the effects of oral finasteride in men, but there hasnt been much research since, and no studies that included women.

Light TherapyLow-Level Laser Therapy (LLLT)technologiesusually in theform of laser headbands and hatsthat can be worn at home or in a doctorsofficeare designed to improve folliclefunction and reverse the effects of thinninghair and hereditary hair loss. LLLT is anoninvasive, pain-free and FDA-clearedsolution that uses diodes that emit infraredor red light, says Dr. Ziering. It increasesblood circulation to the scalp and helps thefollicles produce thicker, longer, healthierhairs with improved pigment.

Dr. Rand says there are many doctorswho use LLLT, and while the devices cangrow some hair in carefully selected patients, they tend to work better on thosewho are balding (or quite thin) rather thanthose with moderate thinning. The issue isthat the lights cant penetrate down to thescalp tissue if theres hair in the way, whichis why I prefer combs rather than caps forwomen because they separate the hair, sheexplains. In general, these devices tend towork better on men; however, as technology evolves and more hair loss studies aredone on women, this may change.

Product Pick: The most high-tech headband weveever seen, HairMax LaserBand 41 ($549) delivers follicle-stimulating energyto the scalp via 41 medical-gradelasers and is super easy to use. Justput it on your head, press the buttonand voila. Wearing it three times aweek for just three minutes treatsthe entire scalp.

Platelet-Rich Plasma (PRP)Platelet-rich plasma (PRP)is a newer biotechnologyused to treat early androgenic alopecia or thinning hairand involves drawing a smallsample of the patients bloodfrom the arm before puttingit through a centrifugation process to extractthe blood plasmarich in proteins andgrowth factorsand eliminate the red bloodcells. The plasma is then injected into thehair follicles in thinning regions of the scalp,and the platelets bond to receptors in thestem cells of the scalp tissue," says Las Vegasplastic surgeon Julio L. Garcia, MD, an earlyadopter of PRP treatments. "This activatesthe active hair growth phase and allows hairto grow back where it has been lost.

Dr. Attenello says the treatments are best served for patients with hairthinning, where the hair bulbsstill exist for the PRP to nourish them, rather than thosewith hair loss that has beenpresent for more than a year,where the hair bulb is likelynot intact anymore. Preliminary studies have shown favorable results interms of hair count and density, but larger-scale trials are warranted, she adds.

Most PRP protocols involve treatmentonce a month for three months, and then awaiting period of an additional three monthsbefore results are visible; maintenance treatments every three to six months followingmay be necessary depending on the needsof the patient.

There is also a next-generation form ofPRP called PRF, or platelet-rich fibrin, whichis extracted similarly to PRP, but containsmore growth factors. Dr. Levine prefers PRFbecause it allows the platelets to remain viable while releasing growth factors in a controlled manner that can last hours to days;PRP growth factors only last a few minutes tohours. The benefits of longer-lasting growthfactors, she explains, are that they promotemore hair growth.

Critics point to the treatments lack ofFDA-approval and regulation: Dr. Garciasays there are numerous PRP preparationsystems on the market today with FDA clearance for PRP used in bone graft procedures,but not those for hair. Therefore, the use ofPRP outside this setting is considered off label and scrutinized by the FDA, he explains. Nevertheless, it is widely consideredsafe. Pasadena, CA plastic surgeon GordonSasaki, MD and a team of doctors are currently conducting the first randomized-controlled clinical trials to study the safety andefficacy of low versus high amounts of PRPfor hair regrowth in patients with androgenetic alopecia. By four months, an increasein both terminal [longer, darker hairs] andvellus [shorter, thinner hairs]have been documented withminimal to no side effects orcomplications, Dr. Sasaki notes.Ian Sanderson, president ofskin-care brand AnteAGE, isdedicating his efforts to a newerarea of researchthe topicalapplication of growth factors to battle thinning hairwhich, he hopes, will one daymake PRP injections obsolete.

PRP is mostly effective by deployinggrowth factors like VEGFvascular endothelial growth factorand other stem cellby-products like cytokines to restart dormanthair follicles. Weve been able to engineer atopical treatment solution containing allthose hair growth factors in precise dosages,along with several bio-signals that go beyondwhats possible with PRP alone, he says, adding that its also an alternative to minoxidil.Its been recently understood that one ofminoxidils key mechanisms of action is up regulation of VEGF. Using this growth factortopicallyits a key ingredient in our hairtreatmentswe may make minoxidil obsolete, along with its potential side effects."

THE PRP DEBATENot all doctors see eye to eye when it comes to PRP.PRO: I advocate the use ofPRP for androgenicalopecia in men andwomen. Excellentclinical outcomes areseen after a series offour monthly injections.Diminished hair lossand noticeable newhair growth is typical.Washington, D.C. dermatologist Tina Alster, MD

CON:There is some evidencethat it can benefit thosewith hair loss, but itsstill very controversialbecause theres nota wealth of good data orresearch done underappropriate FDAguidelines. There havealso been some issuesof PRP being done insalons and spas withcatastrophic outcomessuch as contaminationand the spread of HIV.La Jolla, CA plastic surgeon Robert Singer, MD

SURGICAL SOLUTIONWhen nonsurgical solutions have beenexhausted without success, hair restoration surgery can dramatically improveones appearance and self-confidence. Thegold-standard surgical option for hair loss isa hair transplant, which entails surgicallyremoving hair from the back of the headthe area thats most resistant to DHTandimplanting it into thinning areas, says Dr.Attenello. It can be done on both men andwomen, but because women have a differentpattern of hair loss and hair thinning, not allfemale patients are ideal candidates.

The Two Main TypesFollicular Unit Transplantation (FUT): Astrip of hair is removed from the back of thehead, and then the hairs are separated andimplanted into the areas that need to beaddressed, says Dr. Levine. The advantageto FUT is that youre able to cover a largersurface area of baldness, but the downtimeis typically five to seven days.

Follicular Unit Excision and Extraction(FUE): The surgeon (the procedure can beperformed robotically or manually) cutsaround each individual hair follicle, removing and implanting it back into thinning areas. Many surgeons use handheld motorizeddevices to enhance the hair extraction process. These procedures are lengthy and cantake five to eight hours, depending on thesize of the treatment area, says Dr. Levine.But, the recovery time is fastertwo to fivedaysthan with the FUT method and thereis no linear scar on the head.

Power PlayNo matter how skilled the surgeon, robotscan offer exactness human hands cantthey also dont tire after hours in an OR. Themost advanced surgical technology currently available to treat hair loss is the ARTASrobotic system, which utilizes state-of-the-art technology to assist physicians with difficult, manual placements of grafts that require repetitive and precise movements,says Dr. Heil. ARTAS was developed withleading hair transplant physicians and researchers, and offers a clinically proven, permanent solution that provides natural results without stitches, staples or linear scars.Regardless of how the grafts are placed,Dr. Ziering says the hair will continue togrow and function like it normally would,although some routine maintenance maybe needed. Post-procedure, patients cantcolor their hair for four weeks and need toavoid direct sun exposure for at least threemonths to reduce risk of hyperpigmentation, therefore many patients opt to havetransplant surgeries in the winter. Dr. Ziering adds, Noticeably thicker, natural-looking hair growth begins around six months,and the final outcome is seen one year following treatment.

Medically reviewed byLa Jolla, CA plastic surgeon Robert Singer, MD,Eugene, OR plastic surgeon Mark Jewell, MDand Montclair, NJ dermatologist Jeanine B. Downie, MD

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Originally posted here:
The Ultimate Guide to Thinning Hair - NewBeauty Magazine