Stem Cell Clinic

Umbilical Stem Cell Hino Medical Center

By Stem Cell Medical Center

BENEFICIAL FOODS

Serotonin generating foods:Squash, pumpkin, turnips, and celery.

Calcium rich foods:Salmon, sardines, green leafy vegetables, collards, filberts, kale, kelp, mustard greens, prunes, turnip greens, and watercress.

Magnesium rich foods:Avocados, brewers yeast, dulse, green leafy vegetables, salmon, and watercress.

Potassium rich foods:Avocados, brewers yeast, dulse, raisins, and winter squash.

B complex rich foods:Folic acid is in green leafy vegetables, asparagus, and spinach. Vitamin B6 is in poultry, fish oil, vegetables, sunflower seeds. Vitamin B12 is in poultry, fish and fish oil.

Seaweedssuch as wakame and kombu contain sulfated fucoidans which support bone marrow stem cells production.

Avocadosalso contain tyrosine, a mood elevator. The processing of tyrosine in nervous tissue is associated with the growth and guidance of nerve pathways.

Ginsengfor two months can assist with both stem cell growth and stem cell differentiation into specialized cells.

Ginkgo Bilobaalso assists with stem cell growth and differentiation. However do not take this if you are taking other medications.

DHA(docosahexaenoic acid) rich fish and seafood. This omega 3 fatty acid plays a role in nerve cell growth, cognition and also modulates inflammatory responses.

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Umbilical Stem Cell Hino Medical Center

Embryonic Stem Cells and Artificial Stem Cells Are …

By Embryonic Stem Cells

Artificial stem cells, or induced pluripotent stem cells, were made from embryonic stem cells, and then turned into the neural cells pictured here. These artificial stem cells showed a differentiation potential equal to that of embryonic stem cells. [Jiho Choi, HSCI]

Comparing embryonic stem cells and induced pluripotent stem cells can be a little like comparing apples and oranges. Or to put it another way, apples-to-apples comparisons can be hard to arrange because embryonic stem cells and induced pluripotent stem cells may be genetically distinct. In fact, they usually reflect sex, race, and ancestral differences. So, when embryonic stem cells and induced pluripotent stem cells behave differently, as they often do, there is no telling if variations come down to basic genetic differences, or if variations are due to the rigors of reprogrammingwhich adult cells must endure to achieve artificial or induced pluripotency, but which embryonic stem cells are spared.

Because apples-to-apples comparisons are so hard to come by, stem cell scientists have never been able to agree whether embryonic stem cells and induced pluripotent stem cells are equivalent. Even after performing hundreds of experiments, stem cell scientists remained divided. Some experiments suggested that the two types of stem cells functioned similarly and could be used interchangeably, and other experiments suggested that they were fundamentally different.

To help resolve the controversy, stem cell scientists based at Harvard Medical School contrived an experiment that was as much of an apples-to-apples comparison as they could manage. They tricked human embryonic stem cells (hESCs) into becoming human induced pluripotent stem cells (hiPSCs) by first coaxing hESCs to form skin cells. Then they reprogrammed those skin cells into hiPSCs. Finally, they compared the gene products of the hiPSCs with those of the hESCs.

The results of the comparison would be telling, the scientists reasoned, because the hESCs and the hiPSCs were genetically identical. The comparison, it turned out, indicated that the different types of stem cell could not be distinguished by a consistent gene expression signature and were, in the scientists words, molecularly and functionally equivalent.

Details of the scientists work appeared October 26 in the journal Nature Biotechnology, in an article entitled, A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs.

Here we use genetically matched hESC and hiPSC lines to assess the contribution of cellular origin (hESC vs. hiPSC), the Sendai virus (SeV) reprogramming method and genetic background to transcriptional and DNA methylation patterns while controlling for cell line clonality and sex, wrote the authors. We find that transcriptional and epigenetic variation originating from genetic background dominates over variation due to cellular origin or SeV infection.

When the scientists examined the gene products from the hESC and hiPSC cells, they found that only about 50 of the 200,000 genes that make up the human genome were expressed differently. Whats more, the differentially expressed genes were transcribed at such low levels that any apparent transcriptional difference between hESC and hiPSC cells may be nothing more than transcriptional noise.

Finally, the researchers assessed the functional properties of their ES and iPS cell lines. The researchers found that the cell lines had equal potentials to differentiate into neural cells and a variety of other specialized cell lineages.

When using these cell lines and assays, and after considering a number of technical and biological variables, we find that ES cells and iPS cells are equivalent, said Konrad Hochedlinger, Ph.D., a principal faculty member at the Harvard Stem Cell Institute and a senior author of the Nature Biotechnology paper. Dr. Hochedlinger added the caveat that not all practical applications can account for the variables, and that the science has not yet advanced to where iPS cells can replace embryonic stem cells in every situation.

Embryonic stem cells are still an important reference point, against which other pluripotent cells are compared, noted Dr. Hochedlinger. Along those lines, this study increases the 'value' of iPS cells.

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PRP & Stem Cell Treatment in Richmond VA – Dr. Bill Nordt …

By Stem Cell Treatment

If youve been told that surgery was the only option to relieve your joint pain, you may considerStem Cell Therapy or Platelet Rich Plasma (PRP) Injection Therapyoffered by Dr. Nordt in Richmond, Virginia.

It is said that every pain has a story.Your situation and your pain are unique. Accordingly, you should expect treatment that is tailored specifically for you. Although Stem Cell and PRP Injection Therapy isnt for everyone, if youre suffering from acute or chronic pain in your knees, shoulders or hips, you may want to investigate these new fields of regenerative therapy.

These treatments use your bodys own repair mechanism and growth factors to promote healing.Stem cell therapy can be used to address various knee conditions.Many research laboratories are applying stem cell therapy to painful joint conditions.In theory, these cells can replicate, regenerate and restore healthy cellular tissue in areas of delayed or failed healing.

Stem Cell Therapy is a cutting-edge treatment that can be used to treat the pain and symptoms associated with a damaged joint. Pain from joint injury and deterioration is the result of multiple factors, including tissue damage, edema, and inflammation. Whenever possible, efforts to promote natural healing should be utilized. In those instances that ones own healing mechanism is inadequate, measures to jump-start the process may be indicated.

Stem cells are precursor cells and possess the capacity to transform into multiple tissue types. Stem cells are thought to have the potential to stimulate new growth and repair connective tissue. These cells enhance the bodys natural ability to heal itself, either through cell-to-cell mediation or genetic upregulation and matrix production.

Stem cells are either syringe- injected or surgically implanted into a joint to promote healing of the damaged ligaments, tendons and cartilage.

It should be noted that stem cells are still considered experimental in many orthopedic applications. Small or lesser degrees of tissue damage is more likely to benefit from any biological intervention. Stem cells may impart a mechanism to control inflammation, and in that event, can be helpful in any joint condition in which inflammation is a factor.

We are still in the process of understating just which conditions are most amenable to stem cell treatment. It is expected that over time, the indications and processes of stem cell injections will broaden.

Stem cells can be harvested from ones own bone marrow with a needle, known as a bone marrow aspiration or BMA. This can be performed under local or general anesthesia or with sedation. The bone marrow aspiration may be part of a larger surgery or a stand-alone procedure.

Stem cells can also be sourced from laboratories which are commercially prepared. Many commercial preparations are from the amniotic fluid of healthy newborns. They are delivered frozen and injected with a syringe.

Dr. Nordt is considered to be one of Richmonds leading providers of Stem Cell Therapy to be used in the treatment of degenerative various knee and shoulder disorders. To learn more about Stem Cell Therapy, contact Dr. Nordt s staff for more information.

Platelets are small discs that are derived from the fragmentation of precursor megakaryocytes. They play an important role in hemostasis and are a natural source of growth factors. Platelets are one of the key factors in forming blood clots and helping wounds heal.

Platelet Rich Plasma, or PRP, is blood plasma with concentrated amounts of platelets and other growth factors. The high levels of platelets found in PRP contain huge reservoirs of bioactive proteins, including growth factors and signaling proteins that are vital to initiate and accelerate tissue repair and regeneration.

To create Platelet Rich Plasma, a small amount of blood is taken from the patients arm. This blood is then placed in a centrifuge, where it is spun and the platelets are separated from the rest of the blood components. This takes less than 15 minutes and increases the concentration of platelets and growth factors up to 500%.

The specially prepared platelets are taken and reinjected into and around the point of injury. At this point in the process, the platelets release special growth factors that lead to tissue healing. By injecting injured areas with concentrated platelets, we can increase the growth factors up to five times which promotes temporary relief, is thought to promote overall healing, and stop any inflammation at the site of the injury.

PRP injection is a treatment option for various orthopedic injuries and conditions, which have traditionally required surgery or other extensive treatments. PRP injections are being utilized with increasing frequency and effectiveness in the field of orthopedic medicine.

Some common injuries that are treated with PRP injections include:

PRP injections are a fairly quick procedure that consists of drawing the blood to create Platelet Rich Plasma, preparing the PRP in the centrifuge, and then injecting the PRP into the affected area. The whole process is fairly quick and doesnt require anesthesia. This is a highly effective treatment that can be used to avoid intrusive joint surgery that would require a much longer period of rehabilitation.

Dr. Nordt is one or Richmonds leading providers of PRP Injection Therapy for the use of alleviating muscle and joint pain related to various orthopedic injuries and conditions. To learn more about PRP Injection Therapy, contact Dr. Nordts staff for more information.

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PRP & Stem Cell Treatment in Richmond VA - Dr. Bill Nordt ...

Stem Cell Therapy for Knees: Definitive Guide [with Patient …

By Stem Cell Treatment

The stem cell procedure for the treatment of knee pain is minimally invasive, takes about 3 hours, and patients walk out of the office on their own following treatment. To start, stem cells are harvested from your abdominal or love handle fat using high tech, minimally-invasive liposuction equipment. Stem cells from your bone marrow are also utilized. The bone marrow concentrate is harvested using a specially designed, low-trauma needle which is placed into the posterior iliac crest under live x-ray guidance.

Mild IV sedation, in combination with local anesthetic, is used to provide patient comfort during the procedure. The harvested cells are then prepared for injection using an advanced separation and centrifugation process.

With the use of live x-ray guidance, the cells and growth factors are injected into the affected knee joint under sterile conditions. Dr. Brandts extensive experience with knee injections, along with the aid of the appropriate image guidance, ensures the cells are reaching their targeted area so you have the best chance for improvement.

To complement the high stem cell count achieved with the use of adipose derived stem cells, we often utilize PRP, A2M, and placental derived growth factors during our knee procedures and follow-up treatments.

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Goodie Mob – Cell Therapy

By Uncategorized

Goodie Mob's official music video for 'Cell Therapy'. Click to listen to Goodie Mob on Spotify: http://smarturl.it/GMobSpotify?IQid=G...

As featured on Dirty South Classics. Click to buy the track or album via iTunes: http://smarturl.it/GMobDSCiTunes?IQid... Google Play: http://smarturl.it/GMobCTplay?IQid=GM... Amazon: http://smarturl.it/GMobDSCAmz?IQid=GM...

More from Goodie Mob They Don't Dance No Mo': https://youtu.be/vDmGnGueik8 Black Ice (Sky High): https://youtu.be/F9ULbmCvmxY Soul Food: https://youtu.be/nKO43xG66OI

More great Classic Hip Hop videos here: http://smarturl.it/ClassicHipHop?IQid...

Follow Goodie Mob Website: http://goodiemobmusic.com/ Facebook: https://www.facebook.com/GoodieMobMusic Twitter: https://twitter.com/GoodieMobMusic Instagram: https://instagram.com/goodiemob/

Subscribe to Goodie Mob on YouTube: http://smarturl.it/GMobSub?IQid=GMobCT

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Lyrics:

When the scene unfolds Young girls thirteen years old Expose themselves to any Tom, Dick, and Hank Got mo' stretch marks than these hoes Hollin they got rank See Sega ain't in this new world order Dem experimenting in Atlanta, Georgia United Nations, overseas they trained assassins to do search and seize Ain't knocking or asking Dem coming for niggas like me Po' white trash, like they Tricks like her back in slavery Concentration camps lace with gas pipes lines Inferno's outdoors like they had back When Adolf Hitler was living in 1945 Listen to me now, believe me Later on in the future look it up Where they say it? Aint no more Constitution In the event of a race war Places like operation heartbreak hotel Moments tear until air tight vents seat off despair Dem say expect no mercy Foot you should be my least worries got to deal with Where my W-2's, 1099's Unmarked black helicopters swoop down And try to put missiles in mines

Who's that peeking in my window POW nobody now

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Goodie Mob - Cell Therapy

6 Pros and Cons of Adult Stem Cells | Green Garage

By Adult Stem Cells

Adult stem cells can be found in tissues in the body, including, marrow, skin, brain, skeletal muscle and liver cells. An adult stem cell is an undifferentiated cell that can replicate itself and repair a damaged tissue. Having said this, scientists believe that adult stem cells can play a significant role in the science of medicine. However, despite the potential benefits attributed to these cells, there are also criticisms about them. Here are the contentious views from two opposing groups:

1. Used for Transplants Proponents of the use of adult stem cells posit that for decades, stem cells from the bone marrow have been used for transplants. These are blood-forming cells, also known as adult hematopoetic cells. And since new evidence that they can also be inside the brain and heart, there is a big possibility for scientists can do further research studies to use these cells for therapies based on transplantation.

2. Lesser Possibility of Rejection Supporters of the use of adult stem cells for transplantation claim that since these cells come from the patients own cells, it is less likely for the cells to reject the transplanted cells. This characteristic makes adult stem cells perfect candidates for this procedure.

3. Can Cure Medical Conditions Advocates for adult stem cells stress that they can be used for the treatment of some medical conditions such as Parkinsons disease, rheumatoid arthritis, diabetes and heart disease. By extracting adult stem cells, scientists can grow them directly in laboratories and be used to replace damaged cells like dopamine-producing as well as insulin-producing cells.

1. Limited Availabilty Critics of the use of adult stem cells for transplantation argue that only a small number of stem cells from the tissue can be harvested from a persons body. Moreover, once they are removed, divisibility of these cells is limited, which can be challenging, in terms of generating larger amounts of cells. And since these cells are mature as opposed to embryonic cells, the chances of DNA anomalies are higher since they have been exposed to environment and toxins as they age.

2. One Harvest, One Treatment Another skepticism about the effectiveness of adult stem cells for transplantation is that once these cells are harvested, they can only be used for a particular treatment, say, to replace insulin-producing cells. If a patient gets inflicted with another medical disorder, these cells cannot be used anymore.

3. Expensive and Invasive Apart from the difficulty of harvesting stem cells, the procedure can also be costly such as in hip replacements. It is also an invasive procedure, according to some critics and even if there are companies advertising inexpensive stem cell harvesting, it still costs money. This is also an issue on stem cells harvested and stored for future use. Critics say that the fee for storing cells can be high and patients are at risk of wasting money if the firm closes down.

Adult stem cells will play a major role in the field of medicine with continuous research. However, there will still be controversies surrounding it. By weighing their pros and cons, scientists will be able to develop more ways to maximize the potential of these cells and use it for the betterment of lives.

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6 Pros and Cons of Adult Stem Cells | Green Garage

Stem Cell Medicine | Murdoch Children’s Research Institute

By Stem Cell Medicine

Stem Cell Medicine is the Murdoch Children's Research Institute's (MCRI)world-class research program in stem cells.We havea vision to prepare Australia for the transition from fundamental stem cell research in the lab towardtranslation outcomes using stem cells, with the delivery of human stem cell-based products and clinical practices.

Our research includes stem cell-based disease modelling and drug screening and the development of stem cell therapies and bioengineered tissues (explained in detail below). Embedded in the Royal Children's Hospital, and located in Melbourne's biomedical precinct, MCRI Stem Cell Medicine ensures that we workclosely and collaboratively with key experts in the field, including clinicians, biomedical scientists, engineers, ethicists, as well asthe local and international biotech sector. We also engage closely with key stem cell research networks and bodies including Stem Cells Australia, the Australasian Society for Stem Cell Research, the National Stem Cell Foundation of Australia, and look forward to participating in the International Society for Stem Cell Research annual meeting scheduled in Melbourne 2018.

By consolidating our research talent, fostering collaboration, strategically investing resources, and expanding our infrastructureplatforms, MCRI is now one of the worlds leading institutes in pluripotent stem cell research.

A stem cell is a cell that can generate more stem cells but can also form other specialised types of cells.

The early embryo is formed from embryonic stem cells. These stem cells are pluripotent, which means they are able to divide and program themselves into any other type of cell. Pluripotent cells are no longer present after birth, and while some specialised adult stem cells remain throughout the body in places like the skin, liver, blood and intestine, most adult cells are fully differentiated.

In the lab, we reprogram these adult cell types back into pluripotent stem cells and then differentiate them again into the type of cell we wish to study. These are called induced pluripotent stem cells (iPSCs).

At MCRI, we turn iPSCs into different types of committed cells that the human body is unable to regenerate itself, such as the cells of the kidney and heart. Our researchers are world leaders in both generating iPSCs and generating specific cell types from them.

Using Stem Cell Medicine to Transform Clinical Care and Patient Outcomes

Our vision is to be an Australian and international leader in navigating the transition forthe use of human iPSCs from the lab towardclinical use and practice.The use of iPSCs enables cutting-edgeopportunities to conductpatient-specific disease modelling, personalised drug screening, cell therapy and bioengineered organs built from stem cells.

Our location within the Royal Childrens Hospital and our participation in theMelbourne ChildrensCampusmakes us ideally placed to discover and deliver stem cell medical breakthroughs.

Stem Cell Medicine Expertise

MCRI Stem Cell Medicinehas established a Stem Cell Derivation Facility for generating patient stem cells, and has pioneered protocols for turning these stem cells into heart, blood, cartilage, pancreas, nerves and kidney cells. In early 2017 we also introduced a Gene Editing Facility, currently servicing internally only.

We also have expertise in gene editing, which allows us to correct or create specific gene changes in normal or patient stem cells. Our Translational Genomics Unit is being used to examine tissues made from patient stem cells to monitor the effect of the gene changes on every other gene. This information can be used to validate the link between novel gene changes and disease, and find potential pathways to target with drugs.

Our expertise lies in the generation of stem cells from patients and the differentiation of those stem cells into different specialised tissues. This provides the potential for both patient-based disease modelling and the development of treatments for:

It is now possible to take any cell from a patient and turn this back into a stem cell, which we then have the ability to transform into any other cell type in our labs. This means we can make a stem cell from a patient with a disease and study any gene changes that may have caused the disease. This stem cell can then be differentiated into the cell type that is damaged, such as a nerve, kidney or muscle cell for a 'disease in a dish' approach.

In this way, we can study whether a gene is at fault, and then understand why this change is affecting cell function. Put simply, we make a tissue from the patient to understand their disease.

This provides the possibility of testing new drugs or new therapies to specifically treat that patient.

Human tissue formed using stem cells provides a new approach for the pharmaceutical industry to test drugs before clinical trial, providing an early opportunity to identify drug toxicity and a platform for testing drug efficacy.

Such drug screening has the potential to reduce the use of animals in drug development and enable substantial cost savings in the pharmaceutical industry. Using patient-derived stem cells, it may also be possible to develop personalised treatments by testing these on patient stem cell-derived tissues.

By improving our methods for turning a human stem cell into the many types of tissues present in the body, it will eventually be possible to deliver cells back into patients to treat disease.

Around the world, the first clinical trials using stem cell-derived tissues are being performed to treat blindness, neurological disease and diabetes.

Together with new approaches for making the right cell type, MCRI Stem Cell Medicine is ideally located within a hospital precinct, allowing research into how to deliver the right cells into the right patients and access to the Melbourne Childrens Trial Centre to test safety and patient outcome.

Our research will focus on the treatment of childhood cancer, blood disorders, heart disease and kidney disease.

In some cases, delivering a cell may not be enough. MCRI Stem Cell Medicine also conducts research into approaches for the bioengineering of replacement organs using human cell types generated from stem cells.

The hope is that this will ultimately provide treatments for many conditions, including heart disease, bone disease and kidney disease.

Delivering a cell or bioengineered organ into a patient will face the same challenges seen in conventional organ donation.

Without a good DNA match, the patient will reject their stem cell treatment. To address this, we aim to generate a bank of human stem cells matched to the genetically diverse Australian population. These stem cells, generated from banked cord blood, can be turned into the required cell type for treatment ensuring a good match for the patient being treated.

As the home of the Bone Marrow Donor Institute (BMDI) Cord Blood Bank, MCRI is ideally positioned to establish the first bank of human stem cells (known as a Haplobank) matched for the Australian population.

Tailored to the ethnic diversity present in Australia, we will generate human stem cell lines designed to provide a transplantation match for more than 95 per cent of the Australian population.

Stem cell research has attracted considerable public interest and ethical debate. We engage actively with the public to discuss this new area of research, listening to the feedback from the community on any potential concerns and ensuring there is accurate information available for those seeking advice.

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Stem Cell Medicine | Murdoch Children's Research Institute

Adult Stem Cells Show Anti-Aging Potential – genengnews.com

By Adult Stem Cells

April 1, 2018 (Vol. 38, No. 7)

Gail Dutton

Longeveron-Grown Stem Cells Advance on Aging Frailty and Related Disabilities

The stem cell industry took some nasty blows in the early 2000s, when the morality of using embryonic stem cells was questioned and all but a few lines of those cells were excluded from federal research grants. Stem cell experts left the United States for laboratories in Singapore and elsewhere.

In the void that remained, determined stem cell researchers found a way forward: adult stem cells. These cells are found throughout the bodyin bone marrow, hair follicles, and other tissuesand they are multipotent, which means they retain the ability to differentiate into some or all of the specialized cell types of the tissue or organ in which they are embedded. Although adult stem cells lack the pluripotency of embryonic stem cells, they can be reprogrammed to become cells of a specific cell type or induced pluripotent stem cells.

The reprogramming technology developed by stem cell researchers is beginning to bear fruit. Although it is not the low-hanging fruit envisaged at the dawn of stem cell science, it is worth the reach. Applications are being developed for basic research, drug testing, and cell-based therapeutics. This last application area, which promises to generate replacement cells and tissues, may be the most important. It is being explored by several companies that hope to manufacture adult stem cells and thereby reinvigorate regenerative medicine. One of companies is Longeveron. By producing allogeneic mesenchymal stem cells (MSCS) from adult human bone marrow MSCs, Longeveron intends to ameliorate diseases and disabilities associated with aging.

Frailty and Diseases of Aging

Im a cardiologist, but Ive long been interested in medical diseases of aging, begins Joshua M. Hare, M.D., co-founder and CSO, Longeveron. Heart disease primarily affects older people, and age is a huge risk factor.

Frailty associated with aging is an underappreciated problem, he continues, adding that it affects approximately 12% of all people age 65 or older. Besides becoming familiar with the statistics of aging frailty, Dr. Hare saw it in his practice.

Dr. Hare has been thinking about the causes of frailty among otherwise healthy people for at least 20 years. Frailty affects so many people of advanced age, yet almost nothing is being done for this group, he notes. It represents a huge challenge.

Aging, he explains, affects all of our organs. Older hearts dont work as well as younger hearts, all other things being equal. Therefore, we hypothesized that the decline in function was related to the depletion of normal adult stem cells in the body. Then we found a way to replete them. For us, it was a Eureka! moment.

A Biotech Founded to Bring MSCs to Market

Dr. Hare says that he co-founded Longeveron in 2014 for the express purpose of bringing the benefits of MSC technology to a broad population. Universities arent set up to take a new therapeutic through the regulatory steps to bring a drug to market, he points out. Rather than hope a biotech company would be interested in acquiring the research, he took matters into his own hands.

Now Longeveron manufactures MSCs in a proprietary process that the company exclusively licensed from the University of Miami. The cells are introduced into the body intravenously.

The decision to form a company was based on clinical trial results, he says. He and his team had recently conducted and published the results of a 45-patient allogeneiC human mesenchymal stem cells in patients with aging fRAilTy via intravenoUS delivery (CRATUS) study. Not only were the patients showing positive responses, they were doing very, very well, Dr. Hare recalls. This was exciting because there were no successful medical therapies whatsoever for this condition. Those trial results were validated by favorable responses from the geriatric medicine community.

One very public sign of approval came in the form of an editorial in the October 2017 issue of The Journals of Gerontology: Series A. The editorials authors called MSC translation a promising and innovative approach for the treatment of frailty in older humans.

The same issue of the journal also published an article summarizing the results of a small, 30-person study. According to this article, treated patients showed remarkable improvements in physical performance measures and inflammatory biomarkers, both of which characterize frailty syndrome. It concluded that larger trials were warranted.

A Check on Inflammation

The use of MSCs to treat aging is a new and exciting component of biotech, Dr. Hare points out. The theory holds that transplanted MSCs can reduce the chronic inflammation associated with aging and aging-related disease, and thereby improve functional capacity and quality of life. At another level, MSCs have the potential to ameliorate diseases and conditions of aging and, perhaps, even increase longevity.

Despite this potential, Dr. Hare cautions against unrealistic expectations: There are quite a few startups, but few major companies are far along in terms of developing or commercializing this type of therapeutic.

Slightly more than three years old, Longeveron has one therapeutic in Phase IIb clinical trials. Additional trials are open. Some are focused on aging frailty; others are evaluating the cells as a way to treat Alzheimers disease.

Longeveron recently indicated that it had completed enrollment for the second cohort of a Phase I/II trial to test the safety and efficacy of a mesenchymal stem cell therapy for improving influenza vaccine response in patients with aging frailty. The company expects data in 2018.

The Competitive Landscape

Designed from MSCs extracted from bone marrow, the therapeutic product is allogenic. It can be made in large quantities and will be available off-the-shelf. Currently, says Dr. Hare, there are no MSCs on the United States market, although one MSC therapy has been approved. Also, two or three companies are pressing ahead with the development of MSC therapies.

According to Dr. Hare, Longeverons MSCs are unique in two respects: the way they are produced, and the way they are characterized. The specifics of manufacturing and the cells characterization features, however, are confidential. They are trade secrets, Dr. Hare insists.

In a recent interview, Dr. Hare was not only reticent about Longeverons technology, he was also vague about the specific challenges the company has weatheredbut not because all these challenges are particulalry sensitive. He was hurrying to help a patient. He did mention, however, challenges pertaining to the specific (and confidential) methods used to turn a cell into a drug, and the FDA guidances for those methods. The next step for the young company, he said, is to begin negotiations with the FDA to design Phase III trials.

In January, Longeveron won a research grant from the National Institutes of Health (NIH) to develop therapeutics to combat metabolic syndrome. The $1.15 million grant is part of the NIH Fast Track program for small businesses. Earlier, the company received clinical trials funding from Alzheimers Association and Marylands Technology Development Corporation (TEDCO).

Dr. Hare attributes Longeverons success to date to a capable team. Dr. Hare himself is founding director of the University of Miamis Interdisciplinary Stem Cell Institute (ISCI). The scientific advisory board includes thought leaders in geriatrics and cardiology from leading institutions in the United States and Japan. Management team members have histories in academia and corporate operations. None, however, has taken a drug to market.

In the end, a lack of commercialization experience may not matter. Longeveron, recognizing its strengths, plans to partner for that phase of its journey.

A Booming Market

If future trials are as successful as Dr. Hare hopes, Longeverons new therapy will be firmly on the path to commercialization. Given the global population of aging baby boomers, he envisions a broad market for the therapy.

People came to us in droves for the clinical trials, Dr. Hare reports. Having the signs and symptoms of frailty troubles people. They have a palpable sense of becoming disabled simply because they are aging. They want to improve their quality of life.

Regenerative therapies already are gaining regulatory approval for many indications. And, while aging has been largely ignored, it is unlikely to be ignored much longer.

If Longeverons approach is eventually commercialized, in the not-too-distant future, any geriatrician or general practice physician should be able to administer Longeverons MSCs to roll back frailty and possibly reduce other deficits in functional capacity related to aging, such as Alzheimers disease and metabolic syndrome.

Longeveron

Location: Life Science & Technology Park' 1951 NW 7th Avenue, Suite 520, Miami, FL 33136

Phone: (305) 909-0840

Principal: Joshua M. Hare, M.D., Co-Founder and CSO

Number of Employees: 18

Focus: Longeveron, a clinical stage company, produces mesenchymal stem cells to alleviate frailty and other conditions associated with aging.

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Adult Stem Cells Show Anti-Aging Potential - genengnews.com

Home – Seattle Stem Cell Center

By Stem Cell Doctors

Dr. Tami is a certified physician in Aesthetic Medicine, and Integrative & Natural Medicine. She is the type of doctor that other doctors go to. Her unique combination of experience and expertise allows her to not only make her patients look great on the outside, but she is also uniquely qualified to treat patients using the newest and most cutting edge medical and nutritional therapies to heal and retard the effects of hard living, illness and age.

Many physicians treat symptoms, Dr. Tami discovers and treats root causes. What that mean for you is a real diagnosis and a program personally tailored for you by one of the top doctors in the country. Despite her high level of training and accolades her approach is holistic and cutting edge. She is committed to increasing the quality of life for all of her patients. She cares about each of her patients and treats them like family.

Additionally, Dr. Tami is on the faculty of the American Academy of Aesthetic Medicine, and lectures around the world on Aesthetics and Bio-identical hormones for men and women as well as the benefits of stem cell therapy. She is featured as the Health and Beauty Expert for King 5 Health Link regularly, has been the health expert for articles for Shape magazine and has hosted two radio shows about Aesthetic Medicine and cutting edge natural medicine and a best selling author.

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Home - Seattle Stem Cell Center

Stem Cell Therapy Doctors Scottsdale & Phoenix – Stem Cell …

By Stem Cell Doctors

Human stem cells are in your body to generate new and replacement cells, originating and repairing bone, muscle, cartilage, spinal discs and other specialized cells.

Our stem cell therapy doctors have used stem cell treatments to successfully to treat joint injuries and age-related joint degeneration, including osteoarthritis and osteoporosis.

Medical researchers have known for years that stem-cell therapy treatments have the potential to change the face of human aging and alleviate suffering. The capacity for stem cells to self-renew and give rise to ensuing generations offers potential for groups of tissues that can potentially replace diseased and damaged areas in the body, with minimal risk of rejection and side effects.

Your stem cells can buildnewcartilage, ligament and tendon tissue and restore the joints original function. Stem-cell therapy treatment is an alternative to joint replacement surgery. It is non-surgical and minimally invasive. It is low-risk: it doesnt permanently alter your structure with foreign materials as with joint replacement surgery. It leaves your options open.

Stem cells are the big guns of regenerative joint-repair therapy. The treatment concentrates your own stem cells at the site of an injury to exploit their ability to develop into the specific cell types needed to repair and restore your injured joint.

For stem-cell treatment, we will collect stem cells from your body, concentrate them and then precisely place them where healing is needed. Your bodys own healing process will take over from there.

Many of our patients have experienced significantly reduced pain with stem cell therapy we provide in Scottsdale and Phoenix, AZ.

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Stem Cell Therapy Doctors Scottsdale & Phoenix - Stem Cell ...

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