Stem Cell Clinic

Knee Stem Cell Therapy – Vermont Regenerative Medicine

Knee Stem Cell TherapyVermont Regenerative Medicine2017-08-07T18:22:10+00:00 Regenexx Advanced Knee Stem Cell Therapy and Platelet Rich Plasma Procedures for Common Knee Injuries and Knee Osteoarthritis

Regenexx Knee Stem Cell Therapy and Platelet Procedures are breakthrough, non-surgical treatments for people suffering from knee pain due to common injuries to the knee meniscus, ACL or MCL, cartilage, or who are experiencing degenerative conditions, such as osteoarthritis. Traditional options for patients suffering from these conditions include arthroscopic knee surgery to repair ligament tears, or total knee joint replacement. With both surgeries, months of rehab are required, and the patient must be aware of and prepared to take on the risks. As an alternative, the Regenexx Stem Cell Procedure, or Regenexx Super Concentrated Platelet Rich Plasma Procedure may help alleviate knee pain and the conditions that cause it with a simple office injection procedure.

This Regenexx bone marrow derived stem cell treatment outcome data analysis is part of the Regenexx data download of patients who were tracked in the Regenexx advanced patient registry.

This Regenexx bone marrow derived stem cell treatment outcome data analysis is part of the Regenexx data download of patients who were tracked in the Regenexx advanced patient registry following treatment for Meniscus Tears.

This data utilizes LEFS (Lower Extremity Functional Scale) data from our knee arthritis patients treated with stem cell injections. Functional questionnaires ask the patients questions such as how well they can walk, run, climb stairs, etc. The improvements following the Regenexx Stem Cell Procedure are highly statistically significant.

Regenexx has published more data on stem cell safety in peer reviewed medical research for orthopedic applications than any other group world-wide. This is a report of 1,591 patients and 1,949 procedures treated with the Regenexx Stem Cell Procedure. Based on our analysis of this treatment registry data, the Regenexx Stem Cell Procedure is about as safe as any typical injection procedure, which is consistent with what we see every day in the clinic.

Stem Cells are in all of us and they are responsible for healing injured bone, ligaments, tendons and tissues. They are the key component behind the Regenexx Procedures. As we get older or injured, we sometimes cannot get enough of these cells into the area in need. The Regenexx Procedures help solve that problem by precisely delivering a high concentration of stem cells and growth factors into the injured area, aiding your bodys ability to heal naturally. Patients typically avoid the long, painful rehabilitation periods to restore joint strength and mobility following surgery. Regenexx patients are usually encouraged to walk the same day, and most experience little or no down-time from the procedure.

If you are suffering from pain due to an injury, degenerative condition, or prior surgery, you may be a good candidate for this ground-breaking treatment. Please complete the Candidate Form below and you will immediately receive more detailed information on the procedure, along with next steps in determining whether this procedure is right for you. Completion of this form does not constitute a patient/physician relationship.

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Knee Stem Cell Therapy - Vermont Regenerative Medicine

Stem Cell Therapy / drcalapai.net

Stem cells are unquestionably some of the most amazing cells in the human body. These are undifferentiated cells that do not have a direct blueprint or specific destiny. They can become differentiated into specialized cells anywhere throughout the body. They are classified as 2 different types of cells, those that are from embryonic origin and those called adult stem cells.

In the developing embryo, these cells differentiate into ectoderm, endoderm, and mesoderm. These give us rise to our spine, nerves, and all our organs. Adult stem cells are primarily used to repair, replenish, and regenerate tissues.

Historically, stem cells can come from a variety of tissues. These include umbilical cord, fetal tissue, adipose, or the best source bone marrow.

Bone marrow stem cells have the highest numbers of cells when collected and tested compared to all others. This is by far the preferred method of stem cell therapy because of sheer numbers and the fact that they are coming from your own body. This is called autologous therapy.

Stem cell research worldwide goes back over 100 years, the German research is documented back to 1860. There are a wide range of studies and articles describing its dramatic benefit for chronic diseases. Many of these publications are available for you to read on my website.

In performing stem cell therapy, extremely strict guidelines must be followed in coordination with a specialized protocol. This ensures accuracy, sterility, and quality control of the procedure. This information gathered from the procedure, including various forms of documentation can be used for medical publication at a later date. Physician notes and procedure as well as a questionnaire filled out by patients periodically are part of this process. This enables the highest level of procedure and documentation possible.

Initially, patients are examined, appropriate blood or other testing is done and reviewed and schedule is made to begin procedure. Typically, stem cell therapy is done within 2 weeks of initial consultation.

On the day of procedure, stem cells are extracted from Bone Marrow, this takes 5-10 minutes then patients sit and relax while the processing is done. It is then washed and centrifuged 3 times to allow separation of cells and harvest stem cells. At the end of the procedure, microscopic analysis can estimate the number of stem cells available for injection. Injection can be done either into joint, connective tissue, muscle or for all other organs or systemic diseases, intravenously. Intranasal technique also used for MS, Parkinsons, and Alzheimers disease. Intravenous and nebulizer is used for COPD, Emphysema, and Pumonary Fibrosis.

Research shows the therapy may benefit the following:

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered mainstream. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

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Stem Cell Therapy / drcalapai.net

Gene & Cell Therapy Defined | ASGCT – American Society of …

Gene therapy is a field of biomedical research with the goal of influencing the course of various genetic and acquired (so-called multi factorial) diseases at the DNA/RNA level. Cell therapy aims at targeting various diseases at the cellular level, i.e. by restoring a certain cell population or using cells as carriers of therapeutic cargo. For many diseases, gene and cell therapy are applied in combination. In addition, these two fields have helped provide reagents, concepts, and techniques that are illuminating the finer points of gene regulation, stem cell lineage, cell-cell interactions, feedback loops, amplification loops, regenerative capacity, and remodeling.

Gene therapy is defined as a set of strategies that modify the expression of an individuals genes or repair abnormal genes. Each strategy involves the administration of a specific nucleic acid (DNA or RNA). Nucleic acids are normally not taken up by cells, thus special carriers, so-called 'vectors' are required. Vectors can be of either viral or non-viral nature.

Cell therapy is defined as the administration of living whole cells for the patient for the treatment of a disease. The origin of the cells can be from the same individual (autologous source) or from another individual (allogeneic source). Cells can be derived from stem cells, such as bone marrow or induced pluripotent stem cells (iPSCs), reprogrammed from skin fibroblasts or adipocytes. Stem cells are applied in the context of bone marrow transplantation directly. Other strategies involve the application of more or less mature cells, differentiated in vitro (in a dish) from stem cells.

Historically, the discovery of recombinant DNA technology in the 1970s provided the tools to efficiently develop gene therapy. Scientists used these techniques to readily manipulate bacterial and viral genomes, isolate genes, identify mutations involved in human diseases, characterize and regulate gene expression and produce human proteins from genes (e.g. production of insulin in bacteria revolutionized medicine). Later, various viral and non-viral vectors were developed along with the development of regulatory elements (e.g. promoters that regulate gene expression), which are necessary to induce and control gene expression. Gene transfer in animal models of disease have been attempted and led to early success. Various routes of administrations have been explored (injection into the bloodstream, into the ventricles of the brain, into muscle etc).

The development of suitable gene therapy treatments for many genetic diseases and some acquired diseases has encountered many challenges, such as immune response against the vector or the inserted gene. Current vectors are considered very safe and recent gene therapy trials documented excellent safety profile of modern gene therapy products. Further development involves uncovering basic scientific knowledge of the affected tissues, cells, and genes, as well as redesigning vectors, formulations, and regulatory cassettes for the genes. While effective long-term treatments for many genetic and inherited diseases are elusive today, some success is being observed in the treatment of several types of immunodeficiency diseases, cancers, and eye disorders.

Historically, blood transfusions were the first type of cell therapy and are now considered routine. Bone marrow transplantation has also become a well-established medical treatment for many diseases, including cancer, immune deficiency and others. Cell therapy is expanding its repertoire of cell types for administration. Cell therapy treatment strategies include: isolation and transfer of specific stem cell populations, induction of mature cells to become pluripotent cells, administration of effector cells and reprogramming of mature cells into iPSCs. Administration of large numbers of effector cells has benefited cancer patients, transplant patients with unresolved infections, and patients with vision problems.

Several diseases benefit most from treatments that combine the technologies of gene and cell therapy. For example, some patients have a severe combined immunodeficiency disease (SCID) but unfortunately, do not have a suitable donor of bone marrow. Scientists have identified that patients with SCID are deficient in adenosine deaminase gene (ADA-SCID), or the common gamma chain located on the X chromosome (X-linked SCID). Several dozen patients have been treated with a combined gene and cell therapy approach. Each individuals hematopoietic stem cells were treated with a viral vector that expressed a copy of the relevant normal gene. After selection and expansion, these corrected stem cells were returned to the patients. Many patients improved and required less exogenous enzymes. However, some serious adverse events did occur and their incidence is prompting development of theoretically safer vectors and protocols. The combined approach also is pursued in several cancer therapies.

Genome editing (gene editing) has recently gained significant attention, due to the discovery and application of the clustered regularly interspaced short palindromic repeats (CRISPR) system. Actually, genome editing dates back several years and earlier generation genome editing systems are currently tested in clinical trials (such as zinc-finger nucleases). The aim of genome editing is to disrupt a disease-causing mutation or correct faulty genes at the chromosomal DNA. Genome editing can be performed in the patients own cells in vitro and edited cells can be administered to the patient (thus genome editing can be combined with cell therapy). However, it is also possible to perform genome editing in vivo by administering the genome editing agent packaged in viral and non-viral vectors.

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Gene & Cell Therapy Defined | ASGCT - American Society of ...

Stem Cell Therapy | Advanced Regenerative Orthopedics

Stem Cell Therapy involves the use of stem cells to stimulate the bodys natural repair mechanisms to repair, regenerate or replace damaged cells, tissues and organs. This physician-directed therapy is very safe, ethical and does not entail the use of any fetal or embryonic cells or tissue. It has been described as the future of medicine by many prestigious groups including the National Institutes of Health and the Institute of Medicine.

The field of Stem Cell Therapy continues to evolve, focusing on cures rather than just treatments for essentially all types of chronic diseases and conditions, including diabetes and cardiovascular disease, as well as various forms of arthritis and various orthopedic problems. When cells are transplanted into a patient, they do not stay for more than a few days. However, the cells provide a large and robust stimulus to turn on native repair mechanisms. The number of stem cells present in the body and their functional capacity to repair damaged tissue declines with each advancing decade of life, and chronic diseases further impede their ability to respond to chronic injury or damage in the body. This is why research has led to new solutions, which include the use of umbilical cord blood as the source of cells, which have the most potent ability to generate new tissues without risk of rejection. We at Advanced Regenerative Orthopedics use stem cells that are supplied by an FDA-registered cord blood bank.

Stem Cell Therapy and Tissue Engineering are much simpler and effective options that use very powerful young cells to stimulate the patients own native repair mechanisms to regenerate new cartilage and bone. The physician-directed treatment at ARO is a comprehensive approach to a specific joint with the goal of reducing the disabling pain and increasing function.

At Advanced Regenerative Orthopedics, our goal is to provide minimally invasive treatments along with regenerative techniques to target your bodys natural healing ability. Used as part of our innovative, three-tiered approach, physician-directed arthritis stem cell treatment can help patients of all ages get pain relief, increase their joint mobility and enjoy a higher quality of life.

Stem cell therapy can be an effective treatment for those suffering from a broad range of arthritic conditions. By using stem cells for arthritis, Advanced Regenerative Orthopedics stimulates your bodys natural mechanism to repair, regenerate and replace damaged cells within your joints.

If you live in Tampa, Brandon, St. Petersburg, Clearwater, Lakeland, Sarasota, The Villages, Ocala, or the surrounding areas and are interested in learning more about using stem cells for arthritis or any other joint condition, please contact our courteous and efficient office staff today to schedule an appointment. We look forward to discussing the benefits of physician-directed arthritis stem cell treatment with you and determining the best course of treatment to restore your joint health.

As many of our patients travel to us from outside the state of Florida for our world class procedures, our team is very familiar with managing the care & travel for remote patients.

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Stem Cell Therapy | Advanced Regenerative Orthopedics