Stem Cell Clinic

Stem cell-based therapy for targeting skin-to-brain cancer – Medical Xpress

By adminJuly 10, 2017Stem Cell Medical Center

July 10, 2017 Credit: CC0 Public Domain

Investigators from Brigham and Women's Hospital (BWH) and the Harvard Stem Cell Institute have a potential solution for how to kill tumor cells that have metastasized to the brain. The team has developed cancer-killing viruses that can deliver stem cells via the carotid artery, and applied them to metastatic tumors in the brain of clinically relevant mouse models. The investigators report the elimination of metastatic skin cancer cells from the brain of these preclinical models, resulting in prolonged survival. The study, published online this week in the journal PNAS, also describes a strategy of combining this therapy with immune check point inhibitors.

"Metastatic brain tumors - often from lung, breast or skin cancers - are the most commonly observed tumors within the brain and account for about 40 percent of advanced melanoma metastases. Current therapeutic options for such patients are limited, particularly when there are many metastases," says Khalid Shah, MS, PhD, director of the Center for Stem Cell Therapeutics and Imaging (CSTI) in the BWH Department of Neurosurgery, who led the study. "Our results are the first to provide insight into ways of targeting multiple brain metastatic deposits with stem-cell-loaded oncolytic viruses that specifically kill dividing tumor cells."

In their search for novel, tumor-specific therapies that could target multiple brain metastases without damaging adjacent tissues, the research team first developed different BRAF wild type and mutant mouse models that more closely mimic what is seen in patients. They found that injecting patient-derived, brain-seeking melanoma cells into the carotid artery of these preclinical models resulted in the formation of many metastatic tumors throughout the brain, mimicking what is seen in advanced melanoma cancer patients. The injected cells express markers that allow them to enter the brain and are labelled with bioluminescent and fluorescent markers to enable tracking by imaging technologies.

To devise a potential new therapy, the investigators engineered a population of bone marrow derived mesenchymal stem cells loaded with oncolytic herpes simplex virus (oHSV), which specifically kills dividing cancer cells while sparing normal cells. Previous research by Shah and his colleagues shows that different stem cell types are naturally attracted toward tumors in the brain. After first verifying that stem cells injected to the brain would travel to multiple metastatic sites and not to tumor-free areas in their model, the team injected stem cells loaded with oHSV into the carotid artery of metastasis-bearing mice.. Injecting the stem cells loaded with oHSV into the carotid artery, a likely strategy for clinical application, led to significantly slower tumor growth and increased survival, compared with the models that received unaltered stem cells or control injections. The oHSV loaded stem cells are ultimately killed by oHSV mediated oncolysis, preventing the engineered cells from persisting within the brain, which is an important safety component in the therapeutic use of these stem cells.

Due to an increasing body of evidence which suggests that the host immune response may be critical to the efficacy of oncolytic virotherapy, Shah and his colleagues also developed an immunocompetent melanoma mouse model and explored treating with both stem cell loaded oHSV and immune checkpoint blockers such as the ones that target the PD-1/PD-L1 pathway. They found that PD-L1 immune checkpoint blockade significantly improved the therapeutic efficacy of stem cell based oncolytic virotherapy in melanoma brain metastasis.

"We are currently developing similar animal models of brain metastasis from other cancer types as well as new oncolytic viruses that have the ability to specifically kill a wide variety of resistant tumor cells," said Shah, who is also a professor at Harvard Medical School and a principal faculty member at the Harvard Stem Cell Institute. "We are hopeful that our findings will overcome problems associated with current clinical procedures. This work will have direct implications for designing clinical trials using oncolytic viruses for metastatic tumors in the brain."

Explore further: Stem-cell-based therapy promising for treatment of breast cancer metastases in the brain

More information: Wanlu Du el al., "In vivo imaging of the fate and therapeutic efficacy of stem cell-loaded oncolytic herpes simplex virus in advanced melanoma," PNAS (2017). http://www.pnas.org/cgi/doi/10.1073/pnas.1700363114

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

View original post here:
Stem cell-based therapy for targeting skin-to-brain cancer - Medical Xpress

‘That’s the story of the American Dream, right?’ – Post-Bulletin

By adminJuly 10, 2017Stem Cell Medical Center

As a poor youngster staring at a dead-end future in Mexico, Alfredo Quinones-Hinojosa would often lay on the roof of his ramshackle home to dream of a brighter future.

Not even he dared dream his life would become this compelling.

Affectionately known as "Dr. Q," Quinones-Hinojosa recently was hired to be Mayo Clinic's chairman of neurologic surgery at its expanding Florida campus while leading federal research to cure brain cancer.

And, after long consideration, he's also given Disney the green light to turn his life story into a movie.

Expectations are high for the dramatic version of Dr. Q's life, especially since Brad Pitt's Plan B Entertainment's credits includes "12 Years A Slave," "Moonlight," "Selma" and "The Departed," among other blockbusters. The script is expected to be completed by the end of 2017 and it may hit theaters by the end of 2018.

'Knew something good would happen'

While it won't be a true documentary, the truth appears to need little embellishment.

"I used to go to the roof of my house and look at the stars I knew something good was going to happen," Dr. Q said last week by phone from Florida. "There's a lot of people who immigrate to the U.S., but there's not very many who came from nothing to be where (I am) today. That's the story of the American dream, right?"

It's a timely topic with unambiguous political overtones. The Trump administration has cracked down on immigration and increased deportation efforts, which has raised the profile of sanctuary cities across the country.

Dr. Q entered this country illegally, and while he is now a U.S. citizen, it's an open question whether he would have been allowed to reach his current heights in today's politicized climate. As an 18-year-old who jumped a border fence to enter the United States in 1988, he didn't speak English, had no immigration paperwork and was essentially broke.

His first few years were spent in the fields as a migrant worker, earning enough money to learn English at a California community college. He overcame those obstacles to earn an academic scholarship at UC-Berkeley in 1991.

Three years later, his unusual ascent saw him enroll at Harvard, paving the way for him to become a brain surgeon.

'Real people who are changing the world'

The rags-to-riches immigrant story first caught the attention of Plan B's studio execs way back in 2007, while Dr. Q was Professor of Neurosurgery and Oncology, Neurology, and Cellular and Molecular Medicine and Director of the Brain Tumor Stem Cell Laboratory at Johns Hopkins. Jeremy Kleiner, who is now Plan B's co-president with Pitt, made his initial pitch to Dr. Q in 2007.

Dr. Q spent the next eight years respectfully declining Kleiner's periodic overtures. He finally reconsidered after seeing "12 Years A Slave," which won best picture at the 2015 Oscars.

"The world has a tremendous appetite for real stories," Dr. Q said. "I always tell people, 'I'm not an expert on immigration, I'm an expert on brain cancer and brain surgery.' Why my story resonates is we need stories of real people who are changing the world.

"I'm not a fancy person. I still take the trash out of my house and my kids always make fun of me because I know a lot about very little. At the end of the day, I'm just a regular guy but my patients may think differently. They put their lives in my hands."

While filmmakers have been chasing Dr. Q's story for about a decade, Mayo Clinic's pursuit is actually longer. He turned down a 2005 job offer at Mayo's Rochester campus to work at Johns Hopkins.

Dr. Q's decision this April to join the Mayo system finally! was hailed as "a coup" by Gianrico Farrugia, CEO of Mayo's Jacksonville campus. His arrival coincides with a $100 million expansion project, aimed at making Jacksonville a destination medical center for that part of the country and Latin America.

Construction is expected to start later this year on buildings to improve services for complex cancer patients and those seeking neurologic or neurosurgical care. That all falls under Dr. Q's purview.

"Any place in the world would be pleased to have him coming," Farrugia told the Florida-Times Union. "It's a real coup to have him coming to Florida. I think he will have a remarkable impact on Jacksonville."

Forbes has named Dr. Q one of the most creative Mexicans in the world, while Popular Science has also dubbed him among the "Brilliant Ten" for his cancer research. The prestigious William J. and Charles H. Mayo Professor also presented May 18 at Tedx Zumbro River at Autumn Ridge Church in Rochester about his quest to use stem cells to fight brain cancer.

While collaborating daily on an upcoming Disney movie that figures to make him a household name, Dr. Q's says he feels a particular kinship with Mayo due to its humble origins.

"They (Mayo Clinic's founders) went out in the middle of cornfields and built something that is unimaginable," Dr. Q said. "I came and basically went to work in the fields in California. I picked corn when I first came in 1987. I relate so much and in so many ways that I feel I have so many things in common with this amazing institution."

Renowned Cardiothoracic Surgeon, Zain Khalpey, MD, PhD, FETCS, FACS will be Honorably Mentioned in The … – PR NewsChannel (press release)

By adminJuly 10, 2017Stem Cell Medical Center

The International Association of HealthCare Professionals is pleased to welcome Zain Khalpey, MD, PhD, FETCS, FACS, a prominent Cardiothoracic Surgeon to their prestigious organization with his upcoming publication in The Leading Physicians of the World. Dr. Khalpey is a highly trained and qualified surgeon with a vast expertise in all facets of his work and an international reputation for his work with Artificial Hearts remodeling scars in hearts with laser therapy, stem cells and liquid matrices to build a program for heart recovery and regenerative medicine, using precision medicine, but more specifically metabolomics with new artificial intelligence platforms in cardiac surgery to change outcomes for the better. Dr. Khalpey is currently serving as an Associate Professor of surgery, medical imaging, physiological sciences, biomedical engineering, cell & molecular medicine, regenerative & translational medicine, and pharmacology at the University of Arizona College of Medicine in Tucson, Arizona. He also serves as Co-Director of the Heart Transplant and Perfusion Science Programs, Director of the Mechanical Circulatory Support and Artificial Heart Programs, and Director of Robotic Mitral Valve Program in the Division of Cardiothoracic Surgery at Banner University Medical Center. Furthermore, Dr. Khalpey is an Adjunct Professor at Columbia University.

Dr. Khalpey was educated at the University of London, where he graduated Summa Cum Laude with his Medical Degree in 1998. He then gained his PhD in cardiothoracic surgery, bioenergetics, and cardiac transplantation from Imperial College London. Dr. Khalpey completed extensive postgraduate training in both the United Kingdom and the United States. In the United Kingdom, Dr. Khalpey was awarded a very prestigious Winston Churchill Medal for his research as well as a highly prestigious lifetime Hunterian Professorship from the Royal College of Surgeons of England, where he remains a member. His research training to end his PhD was completed at the Mayo Clinic in Rochester, and Massachusetts General Hospital at Harvard in Boston. He then went on to finish his clinical general surgery residency and cardiothoracic heart surgery fellowship at the Brigham and Womens Hospital, also at Harvard in Boston. He went on to New York where he completed a Super-Fellowship in Heart Transplants and Mechanical Circulatory Support Therapies for Advanced Heart Failure, at New York Presbyterian Hospital at Columbia University. He is certified by the American Board of Thoracic Surgery, and has earned the coveted title of Fellow of the European Board of Thoracic and Cardiovascular Surgery and Fellow of the American College of Surgeons.

Dr. Khalpey is a distinguished member of the American Association for Thoracic Surgery, the Society of Thoracic Surgeons, the American Academy of Regenerative Medicine and the Board of Regenerative Medicine. For his extensive expertise and important work, he has been awarded the prestigious Fulbright Distinguished Chair in Medical Sciences in Europe Award. Awards in the Fulbright Distinguished Chairs Program in Europe are viewed as among the most prestigious accolades in the Fulbright Scholar Program. Dr Khalpey holds the coveted Endowed Tony S. Marnell Sr. Chair in Cardiovascular Research at the University of Arizona for his metabolic and stem cell research within the surgical tissue and stem cell biobank he created. Furthermore, Dr. Khalpey is the surgical director of the Extracorporeal Membrane Oxygenator Program, which is the only mobile ECMO service in the state of Arizona. Alongside his exceptional operative team of perfusionists and clinical fellows, Dr. Khalpey helped save NHL hockey player, Tucson Roadrunners Captain, Craig Cunninghams life after sudden cardiac arrest. Dr. Khalpey is the only person on the west coast who is routinely placing left ventricular assist devices (LVADS) through minimally invasive incisions, without the use of a bypass machine, and also strives to revolutionize organ transplantation. Dr. Khalpeys passion for what he does is unparalleled. He is renowned for his innovative and groundbreaking work, and has dedicated his life to providing the best solutions for his patients and community.

View Dr. Zain Khalpeys Profile Here:

https://www.findatopdoc.com/doctor/8137416-Zain-Khalpey-Cardiac-Surgeon-85755

Learn more about Dr. Khalpey here:

https://profiles.arizona.edu/person/zkhalpey and be sure to read his upcoming publication in The Leading Physicians of the World.

About FindaTopDoc.com

FindaTopDoc.com is a hub for all things medicine, featuring detailed descriptions of medical professionals across all areas of expertise, and information on thousands of healthcare topics. Each month, millions of patients use FindaTopDoc to find a doctor nearby and instantly book an appointment online or create a review. FindaTopDoc.com features each doctors full professional biography highlighting their achievements, experience, patient reviews and areas of expertise. A leading provider of valuable health information that helps empower patient and doctor alike, FindaTopDoc enables readers to live a happier and healthier life. For more information about FindaTopDoc, visit: http://www.findatopdoc.com

Go here to see the original:
Renowned Cardiothoracic Surgeon, Zain Khalpey, MD, PhD, FETCS, FACS will be Honorably Mentioned in The ... - PR NewsChannel (press release)

Stem cell therapies breaking barriers – Guardian (blog)

By adminJuly 9, 2017Gene Therapy Clinics

STEM CELL THERAPIES BREAKING BARRIERSPhysicians all over the world are increasingly employing stem cell therapies for the treatment of chronic diseases including hypertension, diabetes, chronic kidney disease, neurological disorders, asthma, diabetes, rheumatoid arthritis, spinal cord injuries, female and male sexual dysfunction, joint pain and autoimmune disease. INSET is Dr. David Ikudayisi, of the Glory Wellness and Regenerative Centre PHOTO CREDIT: http://theconversation.com

Technology offers groundbreaking new treatment option for chronic diseases to patients Physicians all over the world are increasingly employing stem cell therapies for the treatment of chronic diseases including hypertension, diabetes, chronic kidney disease, neurological disorders, asthma, diabetes, rheumatoid arthritis, spinal cord injuries, female and male sexual dysfunction, joint pain and autoimmune disease.

A study published last week in the FASEB Journal showed that a new therapy developed through stem cell technology holds promise as a treatment for chronic asthma.

Also, researchers have successfully patched up damaged hearts to treat heart failure, using the patients own muscle stem cells but another study published last week in journal Circulation found that the treatment could be more harmful than helpful if cardiac stem cells are involved.

In another study published in the journal Science Translational Medicine, team of investigators has successfully repaired severe limb fractures in laboratory animals with an innovative technique that cues bone to regrow its own tissue. If found to be safe and effective in humans, the pioneering method of combining ultrasound, stem cell and gene therapies could eventually replace grafting as a way to mend severely broken bones.

Using new gene-editing technology, researchers have rewired mouse stem cells to fight inflammation caused by arthritis and other chronic conditions. According to the study published in the journal Stem Cell Reports, such stem cells, known as SMART cells (Stem cells Modified for Autonomous Regenerative Therapy), develop into cartilage cells that produce a biologic anti-inflammatory drug that, ideally, will replace arthritic cartilage and simultaneously protect joints and other tissues from damage that occurs with chronic inflammation.

Scientists have for the first time created a special type of neuron from human stem cells that could potentially repair spinal cord injuries. The study was published in the Proceedings of the National Academy of Sciences.

Also, early results of a clinical trial suggest that stem cell therapy may be a promising treatment for erectile dysfunction, after the procedure was found to restore sexual function in men with the condition.

Meanwhile, the ANOVA IRM Stem Cell Centre has opened its doors in Frankfurt, Germany offering a groundbreaking new treatment option to patients worldwide.

One of the pioneers of stem cell therapy in Nigeria, Dr. David Ikudayisi, of the Glory Wellness and Regenerative Centre, with clinics in Abuja and Lagos, told The Guardian that there are several thousand clinical trials based on autologous (patients own) Mesenchymal Stem Cells (MSCs). He said these type of stem cells are relatively easy to obtain from a patient via bone marrow blood or fat tissue and have been shown to hold vast healing potential.

Ikudayisi is a United States (U.S.) Board Certified Internist with a strong passion for regenerative aesthetic and cosmetic medicine.

Ikudayisi said ASCT and Platelet Rich Plasma Therapy (PRPT) are under a new specialty of medicine known as regenerative medicine, which is a specialist segment of medicine that helps people to naturally regenerate and rejuvenate their bodies from the different conditions they may be suffering from without using chemicals or the orthodox medicine we are used to.

ASCT may hold answers to many questions and problems that we doctors believed had no solutions, especially neurological disorders. Adult stem cell therapy with or without PRPT revitalizes and regenerates the body organs and systems; it also reverses and repairs many pending subclinical medical problems before they become apparent, including the diseases that are age-related, Ikudayisi said.

He said that ASCT and PRPT are safe as shown by many published research reports and clinical trials done already. He, however, said this does not guarantee that adverse effects cannot occur if physicians that are not properly trained do the treatment.

The US-trained said ASCT has helped a lot of people all over the world to regain their lives back from debilitating ailments and Nigerians are not left behind. He said there are real people in Nigeria that were either wheelchair bound but now walking freely with occasional use of a cane or using a cane before but now walking without one; diabetes patients are able to have restoration of vision in their eyes, and some feel and look younger.

He said ASCT has helped chronic kidney disease patients in Nigeria that are on haemodialysis to either reduce the frequency of haemodialysis per week or like in a patient that was recommended to have kidney transplant a year ago is now off haemodialysis and off diabetic medications, and remain stable for the last six months.

Ikudayisi said men with erectile dysfunction are now feeling like young men again. He further explained: I would be remiss to mention that the type of treatment protocol, the dosage of stem cells used also play a role in the efficacy of the treatment, and not everyone will respond in the same manner. Most of the patients showed improvements after the first treatment, and the few that needed second treatment went on to see great results after more treatments were done; needless to say that they were elated with the results.

The only groups of patients that will always need more than a couple of transplantation sessions are patients with the neurological disorders. The latest researches and evidence-based studies show the number of treatment session needed to get significant clinical results can decreased by adding Exosomes to the treatment sessions.

Ikudayisi said there are some diseases that conventional treatments have no cure for, but ASCT can reverse the symptoms of those diseases, repair, and regenerate the damaged tissues or organs involved. He explained: In some cases, it significantly slows down the progression of the disorder. For example, it can regenerate the bony joints in arthritis, repair and strengthen partial Rotator cuff tears and avascular necrosis of the hip without surgery, revitalize the sexual organs in men and women, regenerate renal cells in kidney diseases, modulate immune system without use of medications that have very serious side effects in conditions like rheumatoid arthritis, lupus, scleroderma, Crohns disease, etc. Another advantage is its application in neurological disorders like Amyotrophic lateral sclerosis (ALS) and spinal cord injury.

Ikudayisi said ASCT can gradually lower diabetic medications dosage and eventually may get the patients off diabetic medications. This is evidenced by stem cells in a hyperglycemic medium differentiating into pancreatic cells; therefore leading to increased development of new blood vessels, secretion of various products of the immune system, and up-regulation of pancreatic transcription factors and vascular growth factor. This aids the pancreas to regenerate and boost its ability to produce insulin. In stroke patients, stem cells activate cells around the suffering brain tissue to catalyze rapid healing and to improve brain function, thereby restoring motor function. Until recently, it was believed that damage to the brain tissue was permanent. This is being challenged by the evidences of re-growth of brain cells and improvements of neurological function documented with the use of adult stem cells, he said.

Ikudayisi said a procedure called P-Shot for Men uses PRPT to resolve challenges relating to erectile dysfunction by regenerating the damaged tissues. It gives treated men the possibility of saving their relationships by increasing stamina, enjoying bigger and harder genitals, and eventually increasing the length and girth. Orgasm-Shot for Women, the regenerative medicine procedure for womens sexual function, leads to increased ability to have orgasm, better arousal from clitoris stimulation, decreased pain during intercourse, tighter vaginal opening, increased sexual desire and natural lubrication, and increased arousal from G-spot stimulation. In addition, because of the O-Shot rejuvenation capabilities, there is help available for women suffering from urinary stress incontinence without the need for invasive surgery, he said.

Ikudayisi said since the stem cells used are autologous, there is no risk of rejection of the stem cell transplant, but as with any procedure, there is a risk of infection, which can be very minimal or non-existent if done under the right conditions. He said adult stem cells transplantation can also be considered by people looking for alternative treatments especially in the areas of diabetes, hypertension, kidney disease, female and male sexual dysfunction, joint pain, neurological disorder and autoimmune disease.

The regenerative medicine expert, however, said: Currently, the cost of treatment varies, and it is not for everyone. However, you cant place a price tag on life just as the saying goes that Health is wealth.

1 day ago Food and Drink

1 day ago Health

2 days ago Features

3 days ago Features

Here is the original post:
Stem cell therapies breaking barriers - Guardian (blog)

Stem Cell Therapy: You can be sexually active again – Vanguard … – Vanguard

By adminJuly 9, 2017Uncategorized

By David Ikudayisi

Stem Cell Therapy comes in different types. Embryonic Stem Cell Therapy involves the use of embryonic stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo at 4 days old to around 12 days old, leading to the destruction of the blastocyst which raises ethical and religious issues. Therefore, this type of Stem Cell Therapy is not the focus of this piece. The focus is Adult Stem Cells (ADSCs) and Induced Pluripotent Stem Cells (iPSCs). iPSCs are produced in the laboratories by reprogramming adult cells to express embryonic stem cells characteristics whereas ADSCs are cells obtained from an adult patient who will also be the recipient of the same stem cells.

In the United States, we must transplant the cells back to the same patient on the same day, while in some countries, the stem cells can be cultured to increase the quantity of stem cells before transplanting them back to the same patient who donated them.

Stem Cell Transplantation is a complex process that needs the care of experts in Regenerative Medicine, a new speciality of medicine . In order to ensure that science remains as the vehicle for hope and not harm, the controversies associated with the legal, social and legal issues of certain areas of stem cells research and stem cells potential clinical applications must be carefully examined. Advancing treatment and care for patients to save a life is and must be the ultimate goal.

Regenerative Medicine helps people to naturally regenerate and rejuvenate their bodies from the different conditions they may be suffering from without using chemicals or the orthodox medicine we are used to, but Adult Stem Cells Platelet Rich Plasma (PRP), that is, blood plasma that has been enriched with platelets, and contains growth factors which may elicit the gathering of stem cells around the damaged region stimulating cellular proliferation and tissue regeneration. PRP can be used to promote healing of injured tendons, ligaments, muscles, joints and can be applied to various musculoskeletal problems. The process allows your own (autologous) stem cells to be re-introduced into/around areas of damage or chronic disease. As mentioned earlier, the extraction and transplantation of the stem cells are done on the same day in the United States. Bone marrow transplant has been the most widely used Stem Cell Therapy till date, but Adult Adipose-Derived (fat) Stem Cell Therapy is fast gaining popularity as fat harvesting is less invasive than bone marrow harvesting. You get more stem cells from fat than bone marrow, and fat stem cells are not age-dependent. Adult Stem Cell Therapy may hold answers to many questions and problems that we doctors believed had no solutions, especially neurological disorders. The therapy, with or without PRP, revitalizes and regenerates the body organs and systems; it also reverses and repairs many pending subclinical medical problems before they become apparent, including the diseases that are age-related. Generally, Adult Stem Cell Therapy is safe as shown by many published research reports and clinical trials. However, this does not guarantee that adverse effects cant occur if the treatment is done by physicians that are not properly trained.

The therapy has helped a lot of people all over the world to regain their lives from debilitating ailments and Nigerians are not left behind. There are people in Nigeria that were either wheelchair bound and walking with occasional use of a cane before but now walking without one; diabetes patients are able to have restoration of vision in their eyes, and some feel and look younger. It has helped chronic kidney disease patients in Nigeria that are on hemodialysis to either reduce the frequency of hemodialysis per week or like a patient that was recommended to have kidney transplant a year ago but who is now off hemodialysis and off diabetic medications, and remains stable for the past months. Men with Erectile Dysfunction are now feeling like young men again. I cannot but mention that the type of treatment protocol and dosage of stem cells used also play a role in the efficacy of the treatment, and not everyone will respond in the same manner. Most of the patients, in studies, showed improvements after the first treatment, and the few that needed second treatment went on to see great results after more treatments were done; needless to say that they were elated with the results. The only group of patients that will always need more than a couple of transplantation sessions are patients with neurological disorders. Latest researches and evidence-based studies showed the number of treatment sessions needed to get significant clinical results can decrease by adding Exosomes to the treatment sessions.

In a recently publication in Germany, the new concept, developed around 2010 of how stem cells works, was reinforced where it stated that most of the effects of stem cells are through the Paracrine effects, delivered by the Exosomes. Exosomes are extracellular cell-derived vesicles that are present in almost all biological fluids. When secreted by stem cells, Exosomes are those tiny communication vesicles that interact with surrounding cells, thereby creating therapeutic activity. This is called the Paracrine effect. The Paracrine soluble factors (communication vesicles) have specialized functions and play a key role in intercellular signaling and in the following properties immune modulatory, neuroprotective, anti-inflammatory, neurotrophic, angiotrophic, anti-apoptotic and anti-oxidatory. Stem cells also secrete other important proteins and cytokines that have healing properties.

There are some diseases that conventional treatments have no cure for, but Adult Stem Cell Therapy can reverse the symptoms of those diseases, repair and regenerate the damaged tissues or organs affected. In some cases, it significantly slows down the progression of the disorder. For example, it can regenerate the bony joints in arthritis, repair and strengthen partial rotator cuff tears and avascular necrosis of the hip without surgery, revitalize the sexual organs in men and women, regenerate renal cells in kidney diseases, modulate immune system without use of medications that have very serious side effects in conditions like Rheumatoid Arthritis, Lupus, Scleroderma, Crohns disease, etc. Another advantage is its application in neurological disorders like ALS and spinal cord injury.

Adult Stem Cell Therapy can gradually lower diabetic medications dosage and eventually may get the patients off diabetic medications. This is evidenced by stem cells in a hyperglycemic medium differentiating into pancreatic cells; therefore leading to increased development of new blood vessels, secretion of various products of the immune system, and upregulation of pancreatic transcription factors and vascular growth factor. This aids the pancreas to regenerate and boost its ability to produce insulin. In stroke patients, stem cells activate cells around the suffering brain tissue to catalyze rapid healing and to improve brain function, thereby restoring motor function. Until recently, it was believed that damage to the brain tissue was permanent. This is being challenged by the evidences of re-growth of brain cells and improvements of neurological function documented with the use of Adult Stem Cells.

A procedure called P-Shot for Men uses the PRP Therapy to resolve challenges relating to Erectile Dysfunction by regenerating the damaged tissues. It gives treated men the possibility of saving their relationships by increasing stamina, enjoying bigger and harder genitals, and eventually increasing the length and girth. Orgasm-Shot for Women, the regenerative medicine procedure for womens sexual function, leads to increased ability to have orgasm, better arousal from clitoris stimulation, decreased pain during intercourse, tighter vaginal opening, increased sexual desire and natural lubrication, and increased arousal from G-spot stimulation. In addition, because of the O-Shot rejuvenation capabilities, there is help available for women suffering from urinary stress incontinence without the need for invasive surgery.

Since the stem cells used are autologous, there is no risk of rejection of the stem cell transplant. Nevertheless, as with any procedure, there is a risk of infection which can be very minimal or non-existent if done under the right conditions. Adult Stem Cells Transplantation can also be considered by people looking for alternative treatments especially in the areas of diabetes, hypertension, kidney disease, female and male sexual dysfunction, joint pain, neurological disorder and autoimmune disease. The cost of treatment varies, and it is not for everyone. However, you cant place a price tag on life just as the saying goes that health is wealth.

View post:
Stem Cell Therapy: You can be sexually active again - Vanguard ... - Vanguard

Oxford BioMedica signs major deal with Novartis for cell therapy treatment – City A.M.

By adminJuly 9, 2017Uncategorized

An Oxford-based gene and cell therapy group has announced a major deal with Swiss pharmaceuticals company Novartis.

Oxford BioMedica today revealed it signed a deal potentially worth more than $100m (77.1m) with Novartis for the supply of material for its new cell therapy, CTL019.

The agreement builds on an existing relationship between the two companies that collaborated on CTL019, which will launch commercially later this year.

Read more: Novartis earnings fall but new drug raises hopes

The contract is for the supply of lentiviral vectors, which are used to generate CTL019, a treatment for an especially difficult type of leukaemia.

Novartis has flagged the treatment as a potential blockbuster.

The supply agreement is for the next three years, with the potential of an extension to five years, and it includes a $10m upfront payment for Oxford BioMedica.

John Dawson, the boss of Oxford BioMedica, said:

The new deal with Novartis will strengthen the group's balance sheet immediately and will support the group's continued growth over the next three years.

The company is also set to receive royalty payments on future sales of CTL019, which analysts at Jefferies said could earn Oxford BioMedica between 65-75m a year assuming peak sales of at least $1bn, according to Reuters.

Sheena Berry, analyst at N+1 Singer, said: "We had assumed Novartis would establish a new supply agreement with Oxford BioMedica but it is reassuring to have the agreement confirmed. We continue to look forward to regulatory approval of CTL019."

An advisory panel in the US will meet to discuss whether or not to approve CTL019 at a meeting on 12 July.

Read more: Hunt and Clark issue veiled threat over post-Brexit drugs deal

‘Stem-cell tourism’ needs tighter controls, say medical experts – The … – Washington Post

By adminJuly 9, 2017Stell Cell Research

By Reuters By Reuters July 8

Stem cell tourism in which patients travel to developing countries for unproven and potentially risky therapies should be more tightly regulated, according to a group of international health experts.

With hundreds of medical centers around the world claiming to be able to repair tissue damaged by conditions such as multiple sclerosis and Parkinsons disease, tackling unscrupulous advertising of such procedures is crucial.

These therapies are advertised directly to patients with the promise of a cure, but there is often little or no evidence to show they will help or that they will not cause harm, the 15 experts wrote in the journal Science Translational Medicine.

Some types of stem cell transplant mainly using blood and skin stem cells have been approved by regulators after full clinical trials found they could treat certain types of cancer and grow skin grafts for burn patients.

But many other potential therapies are only in the earliest stages of development and have not been approved by regulators.

Stem cell therapies hold a lot of promise, but we need rigorous clinical trials and regulatory processes to determine whether a proposed treatment is safe, effective and better than existing treatments, said one of the 15, Sarah Chan of Britains University of Edinburgh.

The experts called for global action, led by the World Health Organization, to introduce controls on advertising and to agree on international standards for the manufacture and testing of cell- and tissue-based therapies.

The globalization of health markets and the specific tensions surrounding stem cell research and its applications have made this a difficult challenge, they wrote. However, the stakes are too high not to take a united stance.

See more here:
'Stem-cell tourism' needs tighter controls, say medical experts - The ... - Washington Post

Stem Cell and Biobanking – Stem Cell Conferences

By adminJuly 9, 2017Stem Cell Doctors

Conference Series Ltdinvites all the members of Biological Sciences family, from all over the world to join and share research at the10th World Congress on Stem Cell and Biobankingduring 23th& 24thOctober, 2017 at Osaka, Japan, which includes prompt keynote presentations, plenary talks, oral talks, poster presentations and exhibitions.

Theme: Accelerating the Innovative Research &Technology in Stem Cell & Biobanking

Stem Cell Convention 2017aims in proclaim knowledge and share new ideas amongest the professionals, industrialists and students from research area of Stem Cells and Biobanking to share their research experiences and indulge in interactive discussions at the event. This scientific gathering guarantees that offering the thoughts and ideas will enable and secure you the theme Accelerating the Innovative Research &Technology in Stem Cell & Biobanking. Biobanking is the latest trending technology in many fields. The current era fully rolled out with many new Stem cells and Biobanking technologies. In such case more research centres and Hospitals were newly introduced within market which obviously shows the market growth of stem cells and Biobanking techniques. While analyzing the revenue growth of stem cells research, it highly developed from $150 billion USD to $250 billion USD since from 2010-2015. And the annual growth percentage increases from 20-55 percentages.

Track-1

Stem Cells Biology

Stem cellsare undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells. They are found in multicellular organisms. In mammals, there are two broad types of stem cells:embryonic stem cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are found in various tissues. In adult organisms, stem cells andprogenitor cellsact as a repair system for the body, replenishingadult tissues. In a developing embryo, stem cells can differentiate into all the specialized cellsectoderm, endoderm and mesoderm (see induced pluripotent stem cells)but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues.Umbilical cord cells are also included in this Stem Cell Research.

7th Annual Conference on Stem Cell and Regenerative Medicine ,Aug 4-5, 2016, Manchester, UK; 2nd International Conference on Antibodies,July 14-15, 2016 ,Philadelphia, USA; 2nd International Conference on Innate Immunity,July 21-22, 2016 ,Berlin, Germany; 2nd International Congress on Neuroimmunology ,March 31-April 02, 2016, Atlanta, USA; International Conference on Cancer Immunology ,July 28-30, 2016 ,Melbourne, Australia.

Stem cells technologyis a rapidly developing field that combines the efforts of cell biologists,geneticists, and clinicians and offers hope of effective treatment for a variety of malignant and non-malignant diseases. Stem cells are defined astotipotent progenitor cellscapable of self-renewal and multilineage differentiation. Stem Cell s technologysurvive well and show stable division in culture, making them ideal targets for in vitro manipulation. Although early research has focused on hematopoietic stem cells, stem cells have also been recognised in other sites. Research into solid tissue stem cells has not made the same progress as that on hematopoietic stem cells. This is due to the difficulty of reproducing the necessary and precise three dimensional arrangements and tight cell-cell and cell-extracellular matrix interactions that exist in solid organs. However, the ability of tissue stem cells to integrate into the tissue cytoarchitecture under the control of the host microenvironment and developmental cues makes them ideal for cell replacement therapy. Some of the methods of Stem Cells technology include Cord Stem Cell Transplantation, Allogeneic stem cell transplantation.

8th World Congress on Stem Cell Research ,March 20-22, 2017 ,Orlando, USA;International Conference on Cancer Immunology ,July 28-30, 2016 ,Melbourne, Australia; 5th International Conference on Immunology ,October 24-26, 2016 ,Chicago, USA; Cancer Vaccines: Targeting Cancer Genes for Immunotherapy, Mar 610 2016, Whistler, Canada; Systems Immunology: From Molecular Networks to Human Biology, Jan 1014 2016, Big Sky, USA.

Track-3

Stem Cells Therapy Research

Stem cells therapyis the use of stem cells to treat or prevent a disease or condition.Bone marrow transplantis the most widely used stem-cells therapy, but some therapies derived from umbilical cord blood are also in use. Research is underway to develop various sources forstem cells, and to apply stem-cells treatments for neurodegenerative diseases and conditions such as diabetes, heart disease, and other conditions.Cord blood stem cells therapy is highly recommended at the time of delivery to save the umbilical cord of the child to resolve any future health conditions. Umbilical cord stem cells research has more scope to resolve the issues caused due to DNA changes.

4thInternationalConference on Plant Genomics,July 14-15, 2016 ,Brisbane, Australia; 8thWorld Congress on Stem Cell Research,March 20-22, 2017 ,Orlando, USA; 7thAnnual Conference on Stem Cell and Regenerative Medicine,Aug 4-5, 2016, Manchester, UK; 2ndInternationalConference on Tissue preservation and Biobanking,September 12-13, 2016 ,Philadelphia, USA;World Congress on Human Genetics,October 31- November 02, 2016 ,Valencia, Spain.

Track-4

Epigenetics

Epigeneticsis the study of potentially heritable changes in gene expression (active versus inactive genes) that does not involve changes to the underlyingDNA sequence a change in phenotype without a change in genotype which in turn affects how cells read the genes. Epigenetic change is a regular and natural occurrence but can also be influenced by several factors including age, the environment/lifestyle, and disease state. Epigenetic modifications can manifest as commonly as the manner in which cells terminally differentiate to end up as skin cells, liver cells, brain cells, etc. Or, epigenetic change can have more damaging effects that can result in diseases like cancer. At least three systems includingDNA methylation, histone modification and non-coding RNA (ncRNA)-associated gene silencing are currently considered to initiate and sustain epigenetic change. New and ongoing research is continuously uncovering the role of epigenetics in a variety ofhuman disordersand fatal diseases.

InternationalConference on Next Generation Sequencing,July 21-22, 2016 ,Berlin, Germany; 5thInternationalConference on Computational Systems Biology,August 22-23, 2016 ,Philadelphia, USA; 7thInternationalConference on Bioinformatics,October 27-28, 2016 ,Chicago, USA; InternationalConference on Synthetic Biology,September 28-30, 2015 ,Houston, USA; 4thInternationalConference on Integrative Biology,July 18-20, 2016 ,Berlin, Germany.

Track-5

Stem cells apoptosis and signal transduction

Self-renewal and proliferation ofstem cellspopulation is controlled, in part, by induction of apoptosis. The number of stem cells is therefore a balance between those lost to differentiation / apoptosis and those gained through proliferation.Apoptosisof stem cells is believed to be a dynamic process which changes in response to environmental conditions. For example, the release of stem cells factor inhibits apoptosis following spinal cord injury, presumably in an attempt to promotetissue repair. Dysregulation of apoptosis instem cellsis believed to underlie somecancer pathologies, where apoptotic resistance results in uncontrolled growth (i.e. glioblastoma). Controlling apoptosis is also an important focus for studies ofstem cells transplantation, where inhibition may increase the survival of grafted cells during replacement therapy. Harnessing the full therapeutic potential of stem cells will require full elucidation of the signal transduction cascades for proliferation, differentiation, and apoptosis.

7thInternationalConference on Bioinformatics,October 27-28, 2016 ,Chicago, USA; InternationalConference on Synthetic Biology,September 28-30, 2015 ,Houston, USA; 7thAnnual Conference on Stem Cell and Regenerative Medicine,Aug 4-5, 2016, Manchester, UK; 4thInternationalConference on Integrative Biology,July 18-20, 2016 ,Berlin, Germany; 1stInternationalConference on Pharmaceutical Bioinformatics,Jan 2426 2016, Pattaya, Thailand.

Trcak-6

Regenerative medicine

Regenerative medicineis the branch of medicine that develops methods to regrow, repair or replace damaged or diseased cells, organs or tissues. Regenerative medicine includes the generation and use of therapeutic stem cells, tissue engineering and the production of artificial organs.

InternationalConference on Restorative Medicine,October 24-26, 2016 ,Chicago, USA; 3rdWorld Congress onHepatitis and Liver Diseases,October 17-19, 2016 Dubai, UAE; InternationalConference on Molecular Biology,October 13-15, 2016 ,Dubai, UAE; 2nd InternationalConference on Tissue preservation and Biobanking, September12-13, 2016 ,Philadelphia USA; 26thEuropean Congress ofClinical Microbiology, April 912 2016, Istanbul, Turkey;Conference onCell Growth and Regeneration, Jan 1014 2016, Breckenridge, USA.

Track-7

Bio-banks

Biobanksplay a crucial role in biomedical research. The wide array ofbio specimens(including blood, saliva, plasma, and purified DNA) maintained inbiobankscan be described as libraries of the human organism. They are carefully characterized to determine the general and unique features of the continuous cell line and the absence or presence of contaminants, therefore establishing a fundamental understanding about the raw material from which the biological product is being derived and maintained.Biobankscatalog specimens using genetic and other traits, such as age, gender, blood type, and ethnicity. Some samples are also categorized according to environmental factors, such as whether the donor had been exposed to radiation, asbestos, or some other substance that can affecthuman genes.In Biobank Category the most popular biobank projects includes cord blood banking, banking stem cells, baby cord blood banking.

8thWorld Congress on Stem Cell Research,March 20-22, 2017 ,Orlando, USA; 5thInternationalConference onCell and Gene Therapy,May 19-21, 2016 ,San Antonio, USA; 7thAnnual Conference on Stem Cell and Regenerative Medicine,Aug 4-5, 2016 ,Manchester, UK; InternationalConference on Restorative Medicine,October 24-26, 2016 ,Chicago, USA; InternationalConference on Molecular BiologyOctober 13-15, 2016 Dubai, UAE.

Track-8

Stem cells biomarkers

Bio markeris a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A bio marker may be used to see how well the body responds to a treatment for a disease or condition.

In cancer research and medicine, bio markers are used in three primary ways:

To help diagnose conditions, as in the case of identifying early stage cancers (Diagnostic)

To forecast how aggressive a condition is, as in the case of determining a patient's ability to fare in the absence of treatment (Prognostic)

To predict how well a patient will respond to treatment (Predictive).

InternationalConference on Genetic Counseling and Genomic Medicine,August 11-12, 2016 ,Birmingham, UK;World Congress on Human Genetics,October 31- November 02, 2016 ,Valencia, Spain; InternationalConference on Molecular Biology,October 13-15, 2016 ,Dubai, UAE; 3rdInternationalConference on Genomics & Pharmacogenomics,September 21-23, 2015 ,San Antonio, USA; EuropeanConference on Genomics and Personalized Medicine ,April 25-27, 2016 ,Valencia, Spain.

Track-9

Cells & Organ Regeneration

Regenerationmeans the regrowth of a damaged or missing organ part from the remaining tissue. As adults, humans can regenerate some organs, such as the liver. If part of the liver is lost by disease or injury, the liver grows back to its original size, though not its original shape. And our skin is constantly being renewed and repaired. Unfortunately many other human tissues dont regenerate, and a goal inregenerative medicineis to find ways to kick-start tissue regeneration in the body, or to engineerreplacement tissues.

4thCongress on Bacteriology and Infectious Diseases,May 16-18, 2016 ,San Antonio, USA; 2ndWorld Congress on Applied Microbiology,October 31-November 02, 2016 ,Istanbul, Turkey; InternationalConference on Infectious Diseases & Diagnostic Microbiology,Oct 3-5, 2016 ,Vancouver, Canada; InternationalConference on Water Microbiology,July 18-20, 2016 ,Chicago, USA; 5thInternationalConference on Clinical Microbiology,October 24-26, 2016 ,Rome, Italy.

Track-10

Fertility biobanks

Fertility preservation is the effort to help cancer patients retain their fertility, or ability to procreate. Research into howcanceraffects reproductive health and preservation options are growing, sparked in part by the increase in the survival rate of cancer patients. The main methods of fertility preservation are ovarian protection by GnRH agonists, cryopreservation of ovarian tissue, eggs or sperm, or of embryos afterin vitro fertilization. The patient may also choose to use egg or sperm from a donor by third party reproduction rather than having biological children.

4thCongress on Bacteriology and Infectious Diseases,May 16-18, 2016 ,San Antonio, USA; 2ndWorld Congress on Applied Microbiology,October 31-November 02, 2016 ,Istanbul, Turkey; InternationalConference on Infectious Diseases & Diagnostic Microbiology,October 3-5, 2016 ,Vancouver, Canada; InternationalConference on Water Microbiology ,July 18-20, 2016 ,Chicago, USA; 5thInternationalConference on Clinical Microbiology,October 24-26, 2016 ,Rome, Italy.

Track-11

Biobank Ethics

Ethical issues are commonly present in many aspects ofBiobanking. The fact that Biobanks deal with human samples, invading an individual autonomy or limiting self-control, provokes a number of ethical issues. Who is actually competent to give informed consent and donate a sample? When individuals donate part of their body to abiobank, how is that human sample processed? Who is the owner of the sample? Who should decide how it should be used? Who has the right to know individual results of research? These and many more ethical dilemmas exist in the ethical framework of biobanks. With the recent rapid developments in Biobanking, all of these issues are magnified with plenty of further new questions continuously arising. Ethical framework has been the most controversial issue in the domain of biobanking. Thus, it is not surprising that there is a substantial literature focusing on ethical dilemmas in biobanking, such as informed consent, privacy, protection, and returning of results to participants. For many years, researchers at CRB have provided constructive advice on how to deal with ethical aspects of research usinghuman tissuematerial and personal data. For more than 80 years tissue has been derived from human bodies, stored, distributed and used for therapeutic, educational, forensic and research purposes as part of healthcare routine in most western countries.

American Society forBioethicsand Humanities Houston, USA, Association of Bioethics World Congress Edinburgh, UK, Oxford Global Health and Bioethics International Conference Oxford shire, UK, CFP: Global Forum on Bioethics in Research Foundation Merieux, France, Hands On Biobanks 2016 conference Vienna, Austria, Global Biobanking London, UK, TheBiomarker ConferenceOrlando, Florida USA, ART World Congress Symposium on Safe and Efficient IVF New York City, United States, VIII International Postharvest Symposium: Enhancing Supply Chain and Consumer Benefits - Ethical and Technological Issues Cartagena, Murcia, Spain.

4thCongress on Bacteriology and Infectious Diseases,May 16-18, 2016 San Antonio, USA; 2ndWorld Congress on Applied Microbiology,October 31-November 02, 2016 ,Istanbul, Turkey; InternationalConference on Infectious Diseases & Diagnostic Microbiology,October 3-5, 2016 ,Vancouver, Canada; InternationalConference on Water Microbiology,July 18-20, 2016 ,Chicago, USA; 5thInternationalConference on Clinical Microbiology,October 24-26, 2016 ,Rome, Italy.

Track-12

Market Analysis in Biobanking

The globalbiopreservationmarket is expected to reach USD 3,731.03 Million by 2020 from USD 2,150.48 Million in 2015, growing at a CAGR of 11.65% between 2015 and 2020. Biopreservation is used to ensure the stability, quality and purity ofbiospecimens. With a CAGR of 23.7%, global market value for cryopreservation equipment used instem cellsindustry is anticipated to worth US$2.2 billion by 2015. On a global scale, North America accounts for nearly 35% of the market and will likely witness a higher growth rate in the upcoming years, in comparison with Asia-Pacific. While US accounts for the highest share of the global market value on a country basis, India and China surpasses the US in terms of growth rate anticipated in the near future. As per our analysis, freezers represent more than half of thecryopreservationequipment market value while Cyropreservative reagents stand for a share of close to 20%. The global biopreservation market is poised for rapid growth between 2015 and 2020. The drivers include increasing healthcare expenditure, growing demand for preserving new-borns stem cells, increasing R&D spending on research, and increasing adoption ofregenerative medicine.

InternationalConference on Case Reports,March 31-April 02, 2016 ,Valencia, Spain; 2nd International Meeting onClinical Case Reports,April 18-20, 2016 ,Dubai, UAE; 3rd Experts Meeting onMedical Case Reports,May 09-11, 2016 ,New Orleans, Louisiana, USA; 12thEuro BiotechnologyCongress,November 7-9, 2016 ,Alicante, Spain; 2nd InternationalConference onTissue preservation and Biobanking,September 12-13, 2016 ,Philadelphia, USA.

Track-13

Next Generation Biobanking

Biorepositoriesprovide a resource for researchers to increase understanding of complex diseases. Studies such as the Lung Genomics Research Consortium (LGRC), a two-year project launched in October 2009, are going a step further than standardbiobanking practicesand characterizing the samples with their molecular makeup. The molecular data can then be mined along with the clinical data. Led by National Jewish Health and funded by the National Heart, Lung and Blood Institute, a division of the National Institutes of Health (NIH), the LGRC project consists of five institutions, including Dana-Farber Cancer Institute. Collaborators in the project work with samples banked at theLung Tissue ResearchConsortium (LTRC), which houses tissue samples and blood from lung disease sufferers, primarily chronic obstructive pulmonary disease (COPD), along with a rich set of clinical data from patients.

Immuno-Oncology London UK, Next-Generation Cancer Immunotherapies San Diego, USA, ESBB conference Johannesburg, South Africa, HandsOn Biobanks 2016 conference Vienna, Austria, American Society forBioethicsand Humanities Houston, USA, Craniofacial Morphogenesis &Tissue RegenerationVentura, CA, USA, ISSCR Pluripotency: From basic science to therapeutic applications Kyoto, Japan, Craniofacial Morphogenesis & Tissue Regeneration Ventura, CA, USA, Phacilitate Cell &Gene TherapyWorld Washington D.C., USA, Notch Signaling in Development, Regeneration & Disease Gordon Research Conference Lewiston, ME, USA.

The biobanking market is poised for explosive growth if it can overcome the challenges of an adolescent industry. According to an August 2012 Infiniti Research report titled Global Biobanking Market 2011-2015, the biobanking market will increase 30 per cent from 2011 to 2015 to nearly $183 billion. Growth is being driven by an increase in populationgeneticsstudies, personalized medicine, and the use of genetic information in food safety, forensics, and disease surveillance.

4thCongress on Bacteriology and Infectious Diseases, May 16-18, 2016 San Antonio, USA; 2ndWorld Congress on Applied Microbiology,October 31-November 02, 2016 ,Istanbul, Turkey; InternationalConference on Infectious Diseases & Diagnostic Microbiology,October 3-5, 2016 ,Vancouver, Canada; InternationalConference on Water Microbiology ,July 18-20, 2016 ,Chicago, USA; 5thInternationalConference on Clinical Microbiology,October 24-26, 2016 ,Rome, Italy.

View original post here:
Stem Cell and Biobanking - Stem Cell Conferences

North Central Texas Stem Cell Clinics in conjunction …

By adminJuly 9, 2017Stem Cell Clinics

Our Regenerative Cell Treatment is a revolutionary breakthrough treatment option for people suffering from inflammation, reduced mobility, sports injuries, tissue and ligament damage, or chronic pain. Regenerative Cell Therapy is an injectable regenerative tissue matrix solution, that often times leaves the patient feeling relief after only ONE treatment. This cutting edge treatment takes the best components from all the current non-invasive treatment options and puts them into one.

Why should you use Regenerative Cellular Medicine? It works with the bodys natural ability to heal itself. Unlike treatments that simply address the symptoms, regenerative cell therapy actually promotes the natural process of repair in the body, assisting in restoring degenerated tissue.

Our treatment plans are comprehensive. Not only will we provide you with the most cutting-edge treatment options, but we will also assist you through rehabilitation. Following the custom program created for your specific needs will thoroughly increase the effectiveness.Typically, there is no little to no downtime from cellular therapy.

Private clinics are peddling untested stem cell treatments it’s unethical and dangerous – Yahoo News UK

By adminJuly 9, 2017Stem Cell Clinic

Getty Images/Spencer Platt

Stem cell science is an area of medical research that continues to offer great promise. But as this weeks paper in Science Translational Medicine highlights, a growing number of clinics around the globe, including in Australia, are exploiting regulatory gaps to sell so-called stem cell treatments without evidence that what they offer is effective or even safe.

Such unregulated direct-to-consumer advertising typically of cells obtained using liposuction-like methods not only places the health of individuals at risk, but could also undermine the legitimate development of stem cell-based therapies.

Many academic societies and professional medical organisations have raised concerns about these futile and often expensive cell therapies. Despite this, national regulators have typically been slow or ineffective in curtailing them.

As well as tighter regulations here, international regulators such as the World Health Organisation and the International Council on Harmonisation need to move on ensuring patients desperate for cures arent sold treatments with limited efficacy and unknown safety.

Hundreds of stem cell clinics post online claims that they have been able to treat patients suffering from a wide range of conditions. These include osteoarthritis, pain, spinal cord injury, multiple sclerosis, diabetes and infertility. The websites are high on rhetoric of science often using various accreditation, awards and other tokens to imply legitimacy but low on proof that they work.

osteoporosis strong bones workout old lady

Donna McWilliam/APRather than producing independently verified results, these clinics rely on patient testimonials or unsubstantiated claims of improvement. In so doing these shonky clinics understate the risks to patient health associated with these unproven stem cell-based interventions.

Properly administered informed consent is often overlooked or ignored, so patients can be misled about the likelihood of success. In addition to heavy financial burdens imposed on patients and their families, there is often an opportunity cost because the time wasted in receiving futile stem cells diverts patients away from proven medicines.

The many recent reports of adverse outcomes demonstrate the risks of receiving unproven cell therapies are not trivial. In the USA three women were blinded following experimental stem cell treatment for macular degeneration (a degenerative eye disease that can cause blindness). One man was rendered a quadriplegic following a stem cell intervention for stroke. And a woman whose family sought treatment for her dementia died in Australia.

Other notorious cases involving the deaths of patients include the German government shutting down the X-Cell Centre and the Italian government closing the Stamina Foundation it had previously supported.

REUTERS/Juan Carlos UlateAt present, the only recognised stem cell treatments are those utilising blood stem cells isolated from bone marrow, peripheral blood (the cellular components of blood such as red and white blood cells and platelets) or umbilical cord blood.

Hundreds of thousand of lives have been saved over the last half-century in patients with cancers such as leukaemia, lymphoma and multiple myeloma, as well as rare inherited immune and metabolic disorders.

A few types of cancer and autoimmune diseases may also benefit from blood stem cells in the context of chemotherapy. Different stem cells are also successfully used for corneal and skin grafting.

All other applications remain in the preclinical research phase or are just starting to be evaluated in clinical trials.

Often dismissed by for-profit clinics as red tape hampering progress, the rigour of clinical trials allows for the collection of impartial evidence. Such information is usually required before a new drug or medical device is released into the marketplace. Unfortunately, in the case of for-profit stem cell clinics, their marketing has gazumped the scientific evidence.

Action is required on many fronts. Regulators at both an international and national level need to tackle regulatory loopholes and challenge unfounded marketing claims of businesses selling unproven stem cell interventions.

Researchers need to more clearly communicate their findings and the necessary next steps to responsibly take their science from the laboratory to the clinic. And they should acknowledge that this will take time.

Patients and their loved ones must be encouraged to seek advice from a trained reputable health care professional, someone who knows their medical history. They should think twice if someone is offering a treatment outside standards of practice.

The stakes are too high not to have these difficult conversations. If a stem cell treatment sounds too good to be true, it probably is.

NOW WATCH: How grown men can actually look good in shorts