Stem Cell Treatment in Jacksonville at Cell Surgical …

CSN Florida is a group of highly experienced doctors and medical professionals who specialize in stem cell treatment in Jacksonville for degenerative and inflammatory conditions. The Stem Cell Surgical Center at CSN Florida Northeast Floridas Safest and Most Advanced Stem Cell Treatment Center

With an excellent record in patient safety and a highly experienced surgical team, our fully equipped, on-site, state licensed ambulatory surgical center provides treatment candidates with the safest and most advanced stem cell treatment in Jacksonville and Northeast Florida.

Cell Surgical Network of Florida is Northeast Floridas most advanced Stem Cell Treatment and Research Center. Additionally, CSN Florida was founded and is spearheaded by Dr. Lewis J. Obi; An Internationally recognized Stem Cell Specialist who serves as Medical Director of the Cell Surgical Network of Florida, and also his plastic surgery practice; Obi Plastic Surgery.

Our treatment centers surgical team also brings patients the vast surgical experience of non other than Dr. R. David Heekin; Jacksonvilles top orthopedic surgeon and Medical Director at St. Vincents Medical Centers Orthopedic Center of Excellence. And Dr. Orlando G. Florete; President of the Florida Society of Interventional Pain Physicians, and Medical Director of Institute of Pain Management.

The Cell Surgical Network of Florida is a research affiliate of the National Cell Surgical Network in Los Angeles, California whos primary purpose provide advanced stem cell treatments and document stem cell treatment results under its National Institutional Review Board (IRB).

At our CSN Jacksonville Center, we work with a patients adipose adult mesenchymal stem cells; (The clinical term for adult stem cells derived from a patients own body fat.) This is much different than stem cell treatment being performed by most of todays stem cell centers that still rely on traditional methods of collecting adult mesenchymal stem cells from the patients own blood or bone marrow. Most stem cell treatment centers in the world are currently using stem cells derived from bone marrow.

We however use an advanced, closed sterile system to collect stem cells from the patients own body fat, (adipose derived stem cells). Harvesting stem cells from a patients own body fat is performed under local anesthesia, is much easier than traditional methods, and is less likely to cause infections when performed in a surgical center such as our on-site state licensed ambulatory surgery center at CSN Jacksonville.

Our advanced, closed method of harvesting adult stem cells from fat required a significant investment and is comprised of numerous types of technology. This specialized equipment allows our surgeons to safely convert a patients processed body fat into a clear infra-natant pellet with millions of stem cells, up to 2500 times over quantities obtained from bone marrow! This allows CSN Florida to provide patients with more predictable results in both cosmetic surgery procedures such Dr. Obis exclusive scarless face lift,and in regenerative treatments for sports injuries and arthritic conditions and many other conditions.

Stem Cell Therapy has helped many of our patients recover faster, avoid surgery, and slow or reverse the progression of their condition when faced with painful injuries, medical conditions and diseases. Be sure to check with us about any injuries or medically diagnosed condition you are experiencing or are a victim of. Stem Cell Treatment may be an option that you could consider.

Call (904) 399-0905

Stem Cell Treatment and Stem Cell Therapy is not yet approved by the FDA and is not covered by medical insurance. Therefore, you might wish to consider financing through CareCredit. CareCredit specializes in financing for medical procedures and treatments and has a variety of financing options available. Simply click the link to the right to apply.

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Plasticell signs stem cell research collaborations with Singapore academia – Drug Target Review

news

Plasticell, a developer of stem cell technologies and cell-based therapies, has signed agreements with the Agency for Science, Technology and Research (A*STAR) and the Nanyang Technological University (NTU) to progress its therapeutic stem cell pipeline.

We are delighted to have put together this collaboration which has such enormous potential for the creation of next-generation stem cell products, commented Dr Yen Choo, founder and Executive Chairman of Plasticell.

Separate agreements with the two Singapore research centres encompass technology licensing, collaborative research and scientific exchange visits.

Plasticell will initially collaborate with the laboratories of Professor Peter Drge (School of Biological Sciences, NTU) and Dr Farid Ghadessy (p53Lab, A*STAR) to apply proprietary genome editing technology to insert functional multi-transgene cassettes into specific loci of human stem cell lines.

The engineered lines will be used by Plasticell in multiple projects focused on precisely directed stem cell differentiation, phenotypic screening for drug discovery and in next-generation immuno-oncology applications.

Plasticell is a biotechnology company leading the use of high throughput technologies to develop stem cell therapies. The Companys therapeutic focus is in hematopoietic stem cell therapy, anaemia and thrombocytopenia, cancer immunotherapy and diabetes/obesity.

Plasticells Combinatorial Cell Culture (CombiCult) platform technology, allows it to test very large numbers of cell culture variables in combinations to discover optimal laboratory protocols for the manipulation of stem cells and other cell cultures and has received a number of industry awards including the Queens Award for Enterprise in Innovation and theR&D 100 Award.

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Plasticell signs stem cell research collaborations with Singapore academia - Drug Target Review

A Stem Cell Platform for Accelerating Genetic Disease Research … – Technology Networks

These are neural stem cells in the adult mouse hippocampus. Green: the stem cells and their progeny express protein. Magenta: the hippocampal stem cells generate newborn neurons. Blue: mature granule neurons. Credit: Department of Biomedicine, University of Basel

Researchers at Case Western Reserve University School of Medicine have successfully grown stem cells from children with a devastating neurological disease to help explain how different genetic backgrounds can cause common symptoms. The work sheds light on how certain brain disorders develop, and provides a framework for developing and testing new therapeutics. Medications that appear promising when exposed to the new cells could be precisely tailored to individual patients based on their genetic background.

In the new study, published in The American Journal of Human Genetics, researchers used stem cells in their laboratory to simultaneously model different genetic scenarios that underlie neurologic disease. They identified individual and shared defects in the cells that could inform treatment efforts.

The researchers developed programmable stem cells, called induced pluripotent stem cells, from 12 children with various forms of Pelizaeus-Merzbacher Disease, or PMD. The rare but often fatal genetic disease can be caused by one of hundreds of mutations in a gene critical to the proper production of nerve cell insulation, or myelin. Some children with PMD have missing, partial, duplicate, or even triplicate copies of this gene, while others have only a small mutation. With so many potential causes, researchers have been in desperate need of a way to accurately and efficiently model genetic diseases like PMD in human cells.

By recapitulating multiple stages of the disease in their laboratory, the researchers established a broad platform for testing new therapeutics at the molecular and cellular level. They were also able to link defects in brain cell function to patient genetics.

Stem cell technology allowed us to grow cells that make myelin in the laboratory directly from individual PMD patients. By studying a wide spectrum of patients, we found that there are distinct patient subgroups. This suggests that individual PMD patients may require different clinical treatment approaches, said Paul Tesar, PhD, study lead, Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics, and Associate Professor of Genetics and Genome Sciences at Case Western Reserve University School of Medicine.

The researchers watched in real-time as the patients stem cells matured in the laboratory. We leveraged the ability to access patient-specific brain cells to understand why these cells are dysfunctional. We found that a subset of patients exhibited an overt dysfunction in certain cellular stress pathways, said Zachary Nevin, first author of the study and MD/PhD student at Case Western Reserve University School of Medicine. We used the cells to create a screening platform that can test medications for the ability to restore cell function and myelin. Encouragingly, we identified molecules that could reverse some of the deficits. The promising finding provides proof-of-concept that medications that mend a patients cells in the laboratory could be advanced to clinical testing in the future.

The stem cell platform could also help other researchers study and classify genetic diseases with varied causes, particularly other neurologic disorders. Said Tesar, Neurological conditions present a unique challenge, since the disease-causing cells are locked away in patients brains and inaccessible to study. With these new patient-derived stem cells, we can now model disease symptoms in the laboratory and begin to understand ways to reverse them.

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A Stem Cell Platform for Accelerating Genetic Disease Research ... - Technology Networks

Global Human Embryonic Stem Cell (HESC) Research Report 2014 …

This report analyzes the Global market for Human Embryonic Stem Cell (hESC) Research in US$ Million. Annual estimates and forecasts are provided for the period 2014 through 2022. Market data and analytics are derived from primary and secondary research.

The report profiles 25 companies including many key and niche players such as

Key Topics Covered:

1. INDUSTRY OVERVIEW Stem Cells Research: A Sunrise Sector in Biotechnology Arena Human Embryonic Stem Cells An Introduction Embryonic Stem Cells Sources and Cell Culture Comparison on Adult and Embryonic Stem Cells Advantages and Drawbacks of Various Stem Cells Human Embryonic Stem Cells The Market Perspective Timeline for Embryonic Stem Cell Research Activities: Major Events from 1963 through 2014 Issues Hindering Development of hESC Research Consideration of Best Translational Pathways Pivotal in Ensuring Growth Of hESCs Ethical Issues and Technical Hurdles Bog Down hESC Research Teratomas No Longer an Impediment to Stem Cell Therapy Development Human Embryonic and Induced Pluripotent Stem Cell Research Trends Human Embryonic Stem Cell Research: Key Statistical Highlights Research Topics on hESC and hiPSC by Number of Papers Published: 2011-2013 Haploid Human Embryonic Stem Cell Line: The New Frontier Human Induced Pluripotent Stem Cells Remains Best Alternative for hESC

2. REGULATORY LANDSCAPE Overview Human Embryonic Stem Cell Regulations in Select Countries Worldwide Intellectual Property: WARF Sword Hangs Over New Patents WARF Fails to Gain Patents in Europe Diversity in Patent Regimes Pose Tremendous Challenges International Divide on Patenting Dents hESC Research

3. HESC APPLICATION AND CLINICAL TRIALS Drug Testing Clinical Applications hESC-derived Cardiomyocytes Helps in Better Identification of Cardiotoxicity hESC-derived Cardiomyocytes Provides Physiological Relevant Model For Testing Drug Toxicity Human Pluripotent Stem Cells Hold Immense Potential in Treating Lung Diseases Liver Cells Derived from hESC Shows Potential Benefits in Enabling Drug Development and Modeling Liver Diseases Researchers Succeed in Creating Human Kidney from hESCs hESC offers Hope for Patients with Spinal Cord Injury hESC to Enable Better treatment of Neurodegenerative Disorders Amyotrophic Lateral Sclerosis (ALS) Huntington disease Parkinson Disease hESC Derivatives Showing Way Forward for Eye-related Disorders Age-related Macular Degeneration (AMD) Stargardt Disease Myopic Macular Degeneration Human Embryonic Stem Cells Provide New Options in Fight against Diabetes Type I Diabetes Mellitus Type II Diabetes Mellitus Human Stem Cells Pioneering Heart Disease Treatment hESC Opens Up New Vistas for Dental Treatment

4. COMPETITIVE LANDSCAPE Overview Select Global Players Involved in Developing hESC and iPSC- based Drugs and Products

5. REGIONAL MARKET OVERVIEW The United States Market Overview Funding in Human Embryonic Stem Cell Research Showing Steady Increase Stem Cell Research, including hESC, Attract State Funding Policy Framework Structure on hESC Research in the US Scientific Advice Clinical Research Legislative Position of Select US States Human Stem Cell Regulation A Brief Overview on Major Regulations for hESC in the US Ethical Issues Marr hESC Research Market Role of National Academies in Human Embryonic Stem Cell Research in US Embryonic Stem Cell Research Oversight Committees Opposition Continues in Certain States; Oklahoma Vetoes hESC Research in the State Previous Anti-hESC Research Policy Puts the US at a Disadvantage Wisconsin Alumni Research Foundation: An Enduring but Controversial Legacy The Consumer Watchdog versus WARF Case Timeline of Consumer Watchdog versus Wisconsin Alumni Research Foundation Case Impact of WARF versus Consumer Watchdog case on the hESC market Major Clinical Trials Being Undertaken in hESC Research Space A Glance on Select hESC Clinical Trials Underway in the US Europe Market Overview Overview of Legislations on hESC in Europe hESC Research Legislation in Select EU Countries Policy Framework Overview Clinical Research Major Regulations Covering hESC Market on Pan-European Scale A Glance over Key EU Regulations Governing Human Stem Cell Research Major Differences between EU and the US Legislations Europe Readies 80-Billion War Chest for Research Purposes Patent Laws in EU Covering hESCs European Court of Justice's Clarity on Patents to Boost European hESC Research EC's Stand on hESC Research to Aid Further Infusion of Funding Rest of World Asia-Pacific Overview hESC Research in Select Regional Markets China Chinese hESC Industry in Rapid Development Mode Stem Cell Tourism Powering Chinese hESC Research Market Liberal Chinese Cultural Ethos Power hESC Research Government Funding A Major Source in Chinese hESC Research Market Moral, Political and Material Risks Mar Chinese hESC Research Market Public acceptability and Moral Standards Govern Chinese Patent Law Despite flaws, Ethical Guidelines Enables Rapid Development of hESC Research Market India Regenerative Medicine and Stem Cell Biology Gaining Ground in India India Streamlines Stem Cell Research Industry Brief Overview on Major Research Undertakings in Stem Cell Research Korea Stem Cell Research Resumes at a Gradual Pace in Korea Following Years of Hiatus Brazil Brazilian hESC Research Market- An Overview Timeline of Major Historical Events in Brazilian Stem Cell Research The MiHeart Study Project A Case of Successful Initiative Role of Media in Brazilian Stem Cell Therapy Research Field

6. RECENT INDUSTRY ACTIVITY DSMB Grants Approval for Cell Cure Neurosciences' Second Cohort OpRegen Clinical Trial Thermo Fisher Takes Over MTI-GlobalStem Astellas Pharma Acquires Ocata Therapeutics Nutech Mediworld Develops HESC therapy for Type-II Diabetes FDA Grants Fast-Tracks Designation for Cell Cure Neurosciences' OpRegen Takara Bio Completes Acquisition of Cellectis AB

7. GLOBAL MARKET PERSPECTIVE

For more information about this report visit http://www.researchandmarkets.com/research/wv3tcz/human_embryonic

Media Contact:

Laura Wood, Senior Manager press@researchandmarkets.com

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embryonic stem cells – National Geographic News

But obtaining human embryonic stem cells has been controversial, because until now it required the destruction of living embryos.

In the current technology, embryonic stem cells are derived by extracting a mass of cells from an embryo.

Since an early embryo is made of only a few cellsabout eight to tentaking enough to create viable cultures kills the embryo.

"Many people, including [U.S.] President Bush, are concerned about destroying life in order to save life," Lanza said.

U.S. law currently prohibits the use of federal funds for research in which a human embryo is destroyed.

Colony of Stem Cells

Last year Lanza's team showed that it's possible to remove a single cell from a mouse embryo without destroying the embryo.

Through various manipulations, the team grew that cell into a colony of mouse embryonic stem cells.

The extraction procedure is similar to that used during in vitro fertilization to remove a single cell for preimplantation genetic diagnosis (PGD).

PGD is a very early form of diagnosis that tests a human embryo for genetic abnormalities before it is implanted in a woman's uterus.

"This is a relatively simple biopsy procedure that has been used to generate over 2,000 healthy babies," Lanza said.

(See 3-D illustrations of a fetus growing in the womb.)

Using spare human embryos from in vitro fertilization for their most recent study, the scientists used a tiny pipette to extract one cell from each embryo and then grew each cell in a hormone-laden culture.

Just like in the case of PGD tests, embryos with only one cell removed would have survived and gone on to grow into fetuses. To get the most from their samples, however, Lanza's team took several cells from each embryo, destroying the embryos in the process.

From a total of 91 cells taken from 16 embryos, Lanza said his team "obtained two stable human embryonic stem cell lines, which have been growing over eight months at this point."

He says the new stem cell lines behave exactly like conventional embryonic stem cells.

"The resulting cells could be used for genetic testing as well as to create stem cells without affecting the subsequent chances of [the embryos developing into children]," Lanza said.

Ethical Quandary Resolved?

Ronald M. Green, director of the Ethics Institute at Dartmouth College in Hanover, New Hampshire, says the research directly addresses the ethical concerns that many people have about stem cell research.

"It is very, very unusual for scientific research to resolve an ethical quandary, and this is one of those rare instances," Green said. "I do believe it solves the ethical problems."

(Explore the stem cell debate in National Geographic magazine: see photos, take a poll, and join the forum.)

Scientists hope the results will soon lead to the release of U.S. federal funding for embryonic stem cell research.

"This could conform to both the ethical and maybe even the legal thinking that has motivated the [U.S.] President to oppose this," Green said.

"I hope he sees this as an opportunity consistent with his values."

Free Email News Updates Best Online Newsletter, 2006 Codie Awards Sign up for our Inside National Geographic newsletter. Every two weeks we'll send you our top stories and pictures (see sample).

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embryonic stem cells - National Geographic News

Obama Lifts Funding Ban on Embryonic Stem Cell Research

OBAMA LIFTS FUNDING BAN

On March 9, 2009, President Barack Obama lifted, by Executive Order, the Bush administration's eight-year ban on federal funding of embryonic stem research.

Remarked the President, "Today... we will bring the change that so many scientists and researchers, doctors and innovators, patients and loved ones have hoped for, and fought for, these past eight years."

See Obama's Remarks on Lifting the Embryonic Stem Cell Research Ban, in which he also signed a Presidential Memorandum directing development of a strategy for restoring scientific integrity to government decision-making.

BUSH VETOES IN 2006, 2007

In 2005, H.R. 810, the Stem Cell Research Enhancement Act of 2005, was passed by the Republican-led House in May 2005 by a vote of 238 to 194. The Senate passed the bill in July 2006 by a bipartisan vote of 63 to 37.

President Bush opposed embryonic stem cell research on ideological grounds. He exercised his first presidential veto on July 19, 2006 when he refused to allow H.R. 810 to become law. Congress was unable to muster enough votes to override the veto.

In April 2007, the Democratic-led Senate passed the Stem Cell Research Enhancement Act of 2007 by a vote of 63 to 34. In June 2007, the House passed the legislation by a vote of 247 to 176.

President Bush vetoed the bill on June 20, 2007.

PUBLIC SUPPORT FOR EMBRYONIC STEM CELL RESEARCH

For years, all polls report that the American public STRONGLY supports federal funding of embryonic stem cell research.

Reported the Washington Post in March 2009: "In a January Washington Post-ABC News poll, 59 percent of Americans said they supported loosening the current restrictions, with support topping 60 percent among both Democrats and independents.

Most Republicans, however, stood in opposition (55 percent opposed; 40 percent in support)."

Despite public perceptions, embryonic stem cell research was legal in the U.S. during the Bush administration: the President had banned the use of federal funds for research. He did not ban private and state research funding, much of which was being conducted by pharmaceutical mega-corporations.

In Fall 2004 , California voters approved a $3 billion bond to fund embryonic stem cell research. In contrast, embryonic stem cell research is prohibited in Arkansas, Iowa, North and South Dakota and Michigan.

Latest News

In August 2005, Harvard University scientists announced a break-through discovery that fuses "blank" embryonic stem cells with adult skin cells, rather than with fertilized embryos, to create all-purpose stem cells viable to treat diseases and disabilities.

This discovery doesn't result in the death of fertilized human embryos, and thus would effectively respond to pro-life objections to embryonic stem cell research and therapy.

Harvard researchers warned that it could take up to ten years to perfect this highly promising process.

As South Korea, Great Britain, Japan, Germany, India and other countries rapidly pioneer this new technological frontier, the US is being left farther and farther behind in medical technology. The US is also losing out on billions in new economic opportunities at a time when our country sorely needs new sources of revenues.

Background

Therapeutic cloning is a method to produce stem cell lines that were genetic matches for adults and children.

Steps in therapeutic cloning are: 1.

An egg is obtained from a human donor. 2. The nucleus (DNA) is removed from the egg. 3. Skin cells are taken from the patient. 4. The nucleus (DNA) is removed from a skin cell. 5. A skin cell nucleus is implanted in the egg. 6. The reconstructed egg, called a blastocyst, is stimulated with chemicals or electric current. 7. In 3 to 5 days, the embryonic stem cells are removed. 8. The blastocyst is destroyed. 9. Stem cells can be used to generate an organ or tissue that is a genetic match to the skin cell donor.

The first 6 steps are same for reproductive cloning. However, instead of removing stem cells, the blastocyst is implanted in a woman and allowed to gestate to birth. Reproductive cloning is outlawed in most countries.

Before Bush stopped federal research in 2001, a minor amount of embryonic stem cell research was performed by US scientists using embryos created at fertility clinics and donated by couples who no longer needed them.

The pending bipartisan Congressional bills all propose using excess fertility clinic embryos.

Stem cells are found in limited quantities in every human body, and can be extracted from adult tissue with great effort but without harm. Consensus among researchers has been that adult stem cells are limited in usefulness because they can be used to produce only a few of the 220 types of cells found in the human body. However, evidence has recently emerged that adult cells may be more flexible than previously believed.

Embryonic stem cells are blank cells that have not yet been categorized or programmed by the body, and can be prompted to generate any of the 220 human cell types. Embryonic stem cells are extremely flexible.

Pros

Embryonic stem cells are thought by most scientists and researchers to hold potential cures for spinal cord injuries, multiple sclerosis, diabetes, Parkinson's disease, cancer, Alzheimer's disease, heart disease, hundreds of rare immune system and genetic disorders and much more.

Scientists see almost infinite value in the use of embryonic stem cell research to understand human development and the growth and treatment of dieases.

Actual cures are many years away, though, since research has not progressed to the point where even one cure has yet been generated by embryonic stem cell research.

Over 100 million Americans suffer from diseases that eventually may be treated more effectively or even cured with embryonic stem cell therapy. Some researchers regard this as the greatest potential for the alleviation of human suffering since the advent of antibiotics.

Many pro-lifers believe that the proper moral and religious course of action is to save existing life through embryonic stem cell therapy.

Cons

Some staunch pro-lifers and most pro-life organizations regard the destruction of the blastocyst, which is a laboratory-fertilized human egg, to be the murder of human life. They believe that life begins at conception, and that destruction of this pre-born life is morally unacceptable.

They believe that it is immoral to destroy a few-days-old human embryo, even to save or reduce suffering in existing human life.

Many also believe that insufficient attention been given to explore the potential of adult stem cells, which have already been used to successfully cure many diseases. They also argue that too little attention has been paid to the potential of umbilical cord blood for stem cell research. They also point out that no cures have yet been produced by embryonic stem cell therapy.

At every step of the embryonic stem cell therapy process, decisions are made by scientists, researchers, medical professionals and women who donate eggs...decisions that are fraught with serious ethical and moral implications. Those against embryonic stem cell research argue that funding should be used to greatly expand adult stem research, to circumvent the many moral issues involving the use of human embryos.

Where It Stands

Now that President Obama has lifted the federal funding ban for embryonic stem cell research, financial support will soon flow to federal and state agencies to commence the necessary scientific research. The timeline for therapeutic solutions available to all Americans could be years away.

President Obama observed on March 9, 2009, when he lifted the ban:

"Medical miracles do not happen simply by accident. They result from painstaking and costly research, from years of lonely trial and error, much of which never bears fruit, and from a government willing to support that work...

"Ultimately, I cannot guarantee that we will find the treatments and cures we seek. No President can promise that.

"But I can promise that we will seek them -- actively, responsibly, and with the urgency required to make up for lost ground."

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Obama Lifts Funding Ban on Embryonic Stem Cell Research

Human Embryonic Stem Cells (hESC) Market Analysis By … – Yahoo Finance

Human Embryonic Stem Cells (hESC) Market Analysis By ...
Yahoo Finance
NEW YORK, March 29, 2017 /PRNewswire/ -- The global human embryonic stem cells (hESCs) market is anticipated to reach USD 1.06 billion by 2025, ...
Global Human Embryonic Stem Cells (HESC) Market 2017- Astellas ...First Newshawk

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Human Embryonic Stem Cells (hESC) Market Analysis By ... - Yahoo Finance

A Japanese Man Has Become the First Recipient of Donated, Reprogrammed Stem Cells – Futurism

In Brief A Japanese man has become the first recipient of donated, reprogrammed stem cells as a treatment for macular degeneration. If the treatment proves effective against the age-related eye condition, it could halt or prevent the vision loss of the 10 million people in the U.S. who have macular degeneration. A New Treatment for Macular Degeneration

Macular degeneration is the leading cause of progressive vision loss with almost 10million Americans affected by the disease. Currently, there are no known cures for the conditionalthough stem cells might change that entirely.

Macular degeneration occurs when the central portion, the macula, of the retina is deteriorated. This is where our eyes record images and send them to the brain through the optic nerve. The macula is known for focusing our vision, controlling our ability to read, recognize faces, and see objects clearly.

A Japaneseman in his sixties is the worlds first person to receive induced pluripotent stem (iPS) cells donated by a different individual. Rather than tip-toeing around the ethics of embryonic stem cells, scientists were able to remove mature cells from a donor and reprogram them into an embryonic state, which then could be developed into a specific cell-type to treat the disease. Physicians cultivated donated skin cells that were transplanted onto the mans retina to halt the progression of his age-related macular degeneration.

While the mans first surgery was a success, the doctors have said they will make no more announcements about his progress until they have completed all five of the planned procedures. While the effectiveness of this technique cannot be evaluated until the fate of the donated cells and the progression of the patientsmacular degenerationhave been fully monitored, there is increasing interest inusing iPScells for theraputic purposes.

A similar therapy was performed at the Kobe City Medical Center General Hospital in Japan in September 2014, but with a slight difference. In this case, the patient received her own skin cells reprogrammed into retinal cells. As hoped, a year after the surgery her vision had no decline, seemingly halting the macular degeneration. Four more patients in the clinical trial are expected to receive donor cells as well.

The donor-cell procedure, if successful, could help pave the way for the iPS cell bank thatShinya Yamanaka is establishing. An iPS cell bank would allow physicians find theperfect iPS donor per each patients biological signatures. Yamanaka is a Nobel-prizewinning scientist at Kyoto University who pioneered the iPS cells.

Yamanakas idea of a iPS cell bank has the potential torevolutionize modern medicine. It would provide patients with ready-made cells immediately, givinga widespread population access to more treatment options bylower all-around costs. While the risk of genetic defects or a poor donor match still remains, the new procedurecould offer enormous advantagescompared toother alternatives.

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A Japanese Man Has Become the First Recipient of Donated, Reprogrammed Stem Cells - Futurism

Stem cells help explain varied genetics behind rare neurologic disease – Medical Xpress

March 30, 2017

Researchers at Case Western Reserve University School of Medicine have successfully grown stem cells from children with a devastating neurological disease to help explain how different genetic backgrounds can cause common symptoms. The work sheds light on how certain brain disorders develop, and provides a framework for developing and testing new therapeutics. Medications that appear promising when exposed to the new cells could be precisely tailored to individual patients based on their genetic background.

In the new study, published in The American Journal of Human Genetics, researchers used stem cells in their laboratory to simultaneously model different genetic scenarios that underlie neurologic disease. They identified individual and shared defects in the cells that could inform treatment efforts.

The researchers developed programmable stem cells, called induced pluripotent stem cells, from 12 children with various forms of Pelizaeus-Merzbacher Disease, or PMD. The rare but often fatal genetic disease can be caused by one of hundreds of mutations in a gene critical to the proper production of nerve cell insulation, or myelin. Some children with PMD have missing, partial, duplicate, or even triplicate copies of this gene, while others have only a small mutation. With so many potential causes, researchers have been in desperate need of a way to accurately and efficiently model genetic diseases like PMD in human cells.

By recapitulating multiple stages of the disease in their laboratory, the researchers established a broad platform for testing new therapeutics at the molecular and cellular level. They were also able to link defects in brain cell function to patient genetics.

"Stem cell technology allowed us to grow cells that make myelin in the laboratory directly from individual PMD patients. By studying a wide spectrum of patients, we found that there are distinct patient subgroups.

This suggests that individual PMD patients may require different clinical treatment approaches," said Paul Tesar, PhD, study lead, Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics, and Associate Professor of Genetics and Genome Sciences at Case Western Reserve University School of Medicine.

The researchers watched in real-time as the patients' stem cells matured in the laboratory. "We leveraged the ability to access patient-specific brain cells to understand why these cells are dysfunctional. We found that a subset of patients exhibited an overt dysfunction in certain cellular stress pathways," said Zachary Nevin, first author of the study and MD/PhD student at Case Western Reserve University School of Medicine. "We used the cells to create a screening platform that can test medications for the ability to restore cell function and myelin. Encouragingly, we identified molecules that could reverse some of the deficits." The promising finding provides proof-of-concept that medications that mend a patient's cells in the laboratory could be advanced to clinical testing in the future.

The stem cell platform could also help other researchers study and classify genetic diseases with varied causes, particularly other neurologic disorders. Said Tesar, "Neurological conditions present a unique challenge, since the disease-causing cells are locked away in patients' brains and inaccessible to study. With these new patient-derived stem cells, we can now model disease symptoms in the laboratory and begin to understand ways to reverse them."

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Researchers at Case Western Reserve University School of Medicine have successfully grown stem cells from children with a devastating neurological disease to help explain how different genetic backgrounds can cause common ...

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Stem cells help explain varied genetics behind rare neurologic disease - Medical Xpress

Real Life Medical Drama Starring the "Traffic Cop" of Cells – Ottawa Business Journal

Dr. Lauralyn McIntyre is a Senior Scientist in the Clinical Epidemiology Program and a physician in Critical Care at The Ottawa Hospital. She is also an Associate Professor in the Department of Medicine at the University of Ottawa. One main area of interest ties all of these together: septic shock.

Although septic shock is a serious medical condition that has been portrayed on countless medical dramas, it isnt widely understood. Sepsis refers to a bodys response to a serious infection and can manifest itself in many different ways. The new definition refers to a serious infection and at least one dysfunctional organ. This could be your brain, lungs, kidneys, or bone marrow and it could happen to anyone especially individuals with chronic diseases or suppressed immune systems. If symptoms include low blood pressure, its called septic shock and carries with it a high mortality rate and risk of long-term complications for those who survive.

Over time, the medical community has made some improvement in patient outcomes with better identification, resuscitation, and antibiotics. Survivors, however, are often faced with serious long-term issues including psychological and post-traumatic distress, physical weakness, and depression.

It goes on and on, describes Dr. McIntyre. It has a huge burden of illness, both from the perspective of death and even for the people who survive it.

"The type of stem cells that were studying for the treatment of septic shock is completely novel and highly experimental, and has great potential to help patients."

Dr. Lauralyn Mcintyre, The Ottawa Hospital

In Canada, approximately 50,000 patients every year are admitted to hospitals with sepsis or septic shock and 20 to 40 per cent of those patients will die. Dr. McIntyre estimates that sepsis and septic shock account for about 20 per cent of admissions to the ICU at The Ottawa Hospital.

Sepsis and septic shock represent an enormous challenge to patients, to the health care system, and to the caregivers who look after patients after they leave the hospital.

Dr. McIntyre and her colleague Dr. Duncan Stewart, saw a big challenge and lots of room for potential. And thats where stem cells come in. They have been part of a team of specialists whove spent the last five or six years working towards conducting a phase one trial to treat septic shock using stem cells.

The type of stem cells that were studying for the treatment of septic shock is completely novel and highly experimental, and has great potential to help patients, says Dr. McIntyre.

Early research in animal models showed stem cells reduce death in animals with sepsis by calmingthe immune system, restoring organ function and clearing the pathogens faster from the system.

In the phase one trial, medical staff tested stem cell treatment in a small subset of patients with septic shock. They were looking at the tolerability of cells and trying to determine the best dose to use in a subsequent randomized control trial.

That first phase was completed in June and it was a success. It was the first clinical trial of its kind in the world.

The cells were very well tolerated and that has given our team the impetus, the rationale, and the motivation, to go forward to a much larger study, which will be a randomized study, says Dr. McIntyre.

The cells at the centre of the study are stem cells that come from the bone marrow of healthy volunteers who donated their marrow for this clinical trial.

When researchers originally isolated stem cells, they thought they supported blood and the bone marrow. Scientists eventually discovered these cells have a great ability to modulate inflammation. This is a very key process central to septic shock, describes Dr. McIntyre. Its an inflammatory cascade gone awry.

We used to think the cells facilitate their actions by grafting, through implanting themselves in wounded tissue or into the organs that are not working say in sepsis, says Dr. McIntyre. As it turns out they dont make themselves at home, they just seem to cross talk to host cells including cells that are responsible for killing pathogens to regulate them and restore homeostasis. They are like the traffic cops of their microscopic world, and whats more, within a few days they are gone from the system.

This is a critical area of research, not only because of the numbers of patients affected but the trickle down effect that results, such as days lost at work and extra labour for caregivers. Septic shock also comes with a hefty price tag. The estimated cost to the Canadian health care system is $4 billion.

I think its important because theres so much potential to help, says Dr. McIntyre.

The results of the phase one trial will be published within the next few months and funding applications are already being made for the next phase of the trial. If the funding falls into place, the team hopes to begin the next phase by the middle of next year, and take one step closer to a treatment that may help thousands of people across Canada, and the world beyond.

This research was supported by the Canadian Institutes of Health Research, the Ontario Institute for Regenerative Medicine, the Stem Cell Network and The Ottawa Hospital Foundation

To find out more on how you can support stem cell research at The Ottawa Hospital visitohfoundation.ca

This is part of an ongoing series about The Ottawa Hospital. Look for the evolving archive on obj.ca.

Link:
Real Life Medical Drama Starring the "Traffic Cop" of Cells - Ottawa Business Journal