Stem cell treatment may halt spread of multiple sclerosis – The Times (subscription)

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Kat Lay, HealthCorrespondent

A treatment for multiple sclerosis that works by resetting the immune system appears to halt progression of the disease in almost half of patients and reverse the symptoms in some.

A new study found the use of aggressive chemotherapy and a stem cell injection prevented symptoms from worsening for five years in 46 per cent of patients.

MS is caused by the immune system malfunctioning and attacking nerves in the brain and spinal cord. While there is no cure, certain medications can slow the diseases progression. About 100,000 people in the UK and 2.3 million worldwide have MS.

Last year the results of a smaller, 24-patient trial of the treatment in Canada were hailed as remarkable. Seventy per cent of patients experienced a complete stop

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Stem Cell Company Combining Stem Cell Therapy with Hyperbaric Oxygen Treatment – PR Newswire (press release)

TAMPA, Fla., Feb. 20, 2017 /PRNewswire/ -- StemedixInc., a U.S. based stem cell therapy group that specializesin the use of stem cells to treat patients with degenerative conditions, announced today that they are offering their patients a powerful treatment combination; Hyperbaric Oxygen Therapy (HBOT) and Stem Cell Therapy. According to research, the benefit of having HBOT treatments in conjunction with stem cell therapy is increasing the synthesis of nitric oxide, which signals the release of stem cells.

A recentstudyby researchers fromNeural Regeneration Researchfound results showing test subjects that underwent bothmesenchymalstem cell transplantation and HBOT had better neurological outcomes and better cognitive performance scores than subjects that endured only one type of treatment. Anotherstudyat the University of Pennsylvania School of Medicine, led by researcher StephenThom, MD, PhD, found that HBOT increases stem cell activity. After one treatment, the stem cell concentration doubled and after 20 treatments, they increasedeightfold.

Based on the growing interest and success, Fred Palmer, director of operations, at Stemedixsaid, "We are very proud to be working with the most recent and advanced technologies in the industry today. This combination of hyperbaric oxygen and stem cell therapies is progressively becoming the recommended treatment from our physicians and the selected treatment of our patients. Studies coupled with our own results we have seen thus far have been very impressive and supportive to our decision to offer this adjoining treatment."

Stemedix is now combining their stem cell therapy treatments with HBOT which allows for healing to occur that enables fibroblasts (tissue cells), capillaries (circulatory), osteoblasts (bone cells) andstem cellsto be stimulated. Without appropriate levels of oxygen in the tissue, healing cannot take place. With HBOT, oxygen is dissolved into all of the body's fluids, plasma, central nervous system fluids, lymph, and bone. In addition, the areas of the body that are lacking oxygen will begin to receive oxygen again.

To learn more about StemedixHBOT and stem cell therapy, contact Stemedixat 800-531-0831.

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Saitama clinic ordered to halt unauthorized stem cell ‘anti-aging’ therapy using umbilical cord blood – The Japan Times

SAITAMA The health ministry on Monday ordered a Saitama clinic to stop injecting stem cells of human umbilical cord blood into patients as an anti-aging treatment.

Saitama Medical Clinic in Tokorozawa, Saitama Prefecture, was found to have been engaged in such therapy without getting permission from the ministry. The regenerative medicine safety law mandates that all hospitals and clinics submit plans for stem cell therapy and get permission from the ministry beforehand.

The ministry conducted an on-site inspection of the clinic on Friday, based on tips from an outsider, and confirmed the clinic offered the unauthorized therapy, boasting that umbilical cord cell shots would boost health and help with anti-aging.

Several men and women are believed to have undergone treatment there. The ministry has asked the clinic to report the number of cases, any health damage and the kind of stem cells used and how they were obtained.

For clinics to receive approval for medical procedures using cells of others, they need to submit a detailed plan and have it screened by a panel of experts under the health ministry. The clinic had not submitted such a plan.

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Saitama clinic ordered to halt unauthorized stem cell 'anti-aging' therapy using umbilical cord blood - The Japan Times

Multiple sclerosis: Stem cell transplantation may halt disease progression – Medical News Today

New research provides further evidence of autologous hematopoietic stem cell transplantation as an effective treatment for multiple sclerosis, after finding the procedure halted disease progression for 5 years in almost half of patients.

Lead study author Dr. Paolo Muraro, of the Department of Medicine at Imperial College London in the United Kingdom, and colleagues recently reported their findings in JAMA Neurology.

The results come just a fortnight after another study revealed the success of a similar treatment in a small group of patients with relapsing-remitting multiple sclerosis (RRMS).

However, Dr. Muraro and team warn that further trials are needed to determine the efficacy and safety of autologous hematopoietic stem cell transplantation (AHSCT), after a small number of patients died within 100 days of treatment.

In AHSCT, a patient's own stem cells are harvested. The patient is then subject to high-dose chemotherapy to eliminate any diseased cells.

Next, the harvested stem cells are returned to the patient's bloodstream, with the aim of restarting normal blood cell production. In simple terms, AHSCT "resets" the immune system.

"We previously knew this treatment reboots or resets the immune system - and that it carried risks - but we didn't know how long the benefits lasted," notes Dr. Muraro.

For their study, the researchers assessed data from 25 treatment centers across 13 countries, identifying 281 patients with multiple sclerosis (MS) who underwent AHSCT between 1995-2006. Of these patients, 78 percent had a progressive form of MS.

Using the Expanded Disability Status Scale (EDSS), the team evaluated patients' progression-free survival at 5 years after treatment and any improvements in MS symptoms.

An EDSS score of zero represents no disability, seven represents the use of a wheelchair, while 10 represents death from MS. At the beginning of the study, patients had an average EDSS score of 6.5.

Overall, the researchers found that 46 percent of patients experienced no disease progression in the 5 years after treatment.

Patients with RRMS - characterized by inflammatory attacks, or "flare-ups," followed by periods of remission - had the best outcomes, with 73 percent experiencing no worsening of symptoms in the 5 years after AHSCT.

Additionally, patients experienced small improvements in MS symptoms after AHSCT. Patients with progressive MS saw their EDSS score rise by 0.14 a year after treatment, while patients with RRMS experienced a 0.76 increase in their EDSS score.

Patients with a younger age, few immunotherapies prior to AHSCT, and a lower EDSS score at study baseline also showed better outcomes with AHSCT.

While these findings show promise for the use of AHSCT for patients with MS, the team notes that there were eight deaths in the 100 days after AHSCT, which were thought to have been treatment related.

AHSCT involves aggressive chemotherapy, which can severely weaken the immune system and increase susceptibility to infection.

"In this study, which is the largest long-term follow-up study of this procedure, we've shown we can 'freeze' a patient's disease - and stop it from becoming worse, for up to 5 years.

However, we must take into account that the treatment carries a small risk of death, and this is a disease that is not immediately life-threatening."

Dr. Paolo Muraro

Dr. Muraro notes that, importantly, this study did not include a group of MS patients who did not receive treatment, further highlighting the need for more studies assessing the safety and efficacy of AHSCT.

"We urgently need more effective treatments for this devastating condition, and so a large randomized controlled trial of this treatment should be the next step," he adds.

Read about a study that links vitamin D level at birth to the risk of MS.

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R3 Stem Cell Now Offering Regenerative Medicine Treatment in Oklahoma City – Satellite PR News (press release)

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Top Stem Cell Therapy in Oklahoma City (844) GET-STEM

Over 85% of patients at Venturis achieve excellent outcomes with regenerative medicine treatment for arthritis, tendonitis, back pain and more!

Oklahoma City, Oklahoma (PRWEB) February 20, 2017

R3 Stem Cell is now offering regenerative medicine treatment in Oklahoma City with a new Center of Excellence. R3 has partnered with Venturis Clinic, who offers stem cell and PRP therapy along with prolozone treatment by the Board Certified doctors. Call (844) GET-STEM for more information and scheduling.

Stem cell therapy is now mainstream, and helps individuals every day avoid the need for possibly risky surgery. Its helping athletes get back on the field faster, avoid joint replacement and finally achieve pain relief with chronic tendonitis conditions. The regenerative treatments are offered by a Board Certified provider in a contemporary setting.

The stem cell and PRP therapy in Oklahoma City are all outpatient with absolutely minimal risk. Unlike cortisone injections, these treatments actually repair and regenerate cartilage, muscle, bone, tendon, ligament and other damaged tissue.

Minimal down time is necessary after the stem cell therapy in Oklahoma City, which is the opposite of traditional surgery. The treatments contain stem cells, growth factors, concentrated platelets, cytokines and hyaluronic acid. The combination makes for an amazing regenerative environment once injected.

To receive cutting edge regenerative treatment, call Venturis Clinic in Oklahoma City which is now an R3 Stem Cell Center of Excellence at (844) GET-STEM. Also visit https://r3stemcell.com for more information.

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Augmented adoptive cell transfer eradicates solid tumors [PreClinical] – 2 Minute Medicine

1. Combining tumor-specific T cells and pathogen-based immune stimulation, reenergized adoptive cell transfer (ReACT) targeted and eradicated tumor cells in mice.

2. ReACT led to increased migration of activated T cells to the tumors, a metric that correlated with decreased tumor size.

Evidence Rating Level: 2 (Good)

Study Rundown: Because cancer cells can evade being targeted by the bodys immune system, therapies have been developed to alter the tumors immune microenvironment. One therapy, adoptive cell transfer (ACT), involves engineering T cells to target cells that express tumor-associated antigens (TAAs). Although this therapy has potential, the tumor microenvironment causes inhibition of T cell function, preventing the therapys long-term efficacy. Another approach has been to use pathogens that express TAAs to stimulate the immune system. However, since some tumor cells have altered TAAs, they evade being targeted. In this study, these two approaches were combined into a therapy named ReACT: T cells were engineered to target a TAA as well as a bacterial antigen, and the cells were administered along with a bacterial adjuvant.

When treated with ReACT, a majority of mice with implanted melanoma cells experienced tumor eradication. An increased frequency of T cells in the tumor environment correlated with decreased tumor size. In addition, biomarker levels indicated effective T cell migration and activation. A polyclonal form of ReACT was also tested in a mouse model of melanoma; following tumor eradication in these mice, more tumor cells were introduced but failed to survive, demonstrating an immunological memory response induced by this therapy.

This study demonstrated a new approach for a safer and more efficacious cancer immunotherapy. Future studies will need to more closely mimic a clinical model and provide specific data describing the mechanism of T cell function in this therapy.

Click to read the study in PNAS

Relevant Reading: Cancer Immunotherapy: Strategies for Personalization and Combinatorial Approaches

In-Depth [animal study]: The researchers obtained CD8 T cells that expressed a T cell receptor (TCR) that recognizes a TAA specific to murine melanoma cells. These T cells were then engineered to express a TCR that recognizes the antigen ovalbumin (OVA). In mice with melanoma tumors, this treatment was only effective when the T cells were administered in conjunction with OVA conjugated to Listeria (LM-OVA), a model organism used for pathogen-based cancer vaccines. Seven out of 10 mice experienced complete tumor cell eradication (p<0.001). Neither the engineered T cells alone nor the LM-OVA alone was sufficient to produce significant tumor regression.

Next, the properties and functions of the ReACT T cells were analyzed. The CD8 T cells were present at a higher frequency in the ReACT-treated mice and this value negatively correlated to tumor size, with an r-value of -0.699. These T cells had an activated phenotype, with an increased expression of CD44 and other transcription factors as well as a decreased expression of inhibitory receptors such as CTLA-4. These T cells also had a high expression of CXCR3, a chemokine receptor involved in migration to tumor cells.

Finally, polyclonal ReACT was tested in mice with melanoma tumors. Tumor-specific CD8 T cells were generated by stimulating them with dendritic cells presenting a pool of TAAs; the cells were additionally engineered to express the OVA TCR, and administered to mice along with LM-OVA. Eleven out of 16 mice experienced complete tumor eradication. These mice were then reintroduced to the same melanoma cell line and were resistant to tumor relapse, demonstrating the establishment of an immunological memory response.

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2017 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

2 Minute Medicines The Classics in Medicine: Summaries of the Landmark Trials is available now in paperback and e-book editions.

This text summarizes the key trials in:General Medicine and Chronic Disease, Cardiology, Critical and Emergent Care, Endocrinology, Gastroenterology, Hematology and Oncology, Imaging, Infectious Disease, Nephrology, Neurology, Pediatrics, Psychiatry, Pulmonology, and Surgery.

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R3 Stem Cell Now Offering Regenerative Medicine Treatment in Las Vegas and Henderson Nevada – PR Web (press release)

Top Stem Cell in Las Vegas and Henderson NV (844) GET-STEM

Las Vegas, Nevada (PRWEB) February 20, 2017

R3 Stem Cell is now offering regenerative medicine treatment in Las Vegas and Henderson Nevada. Treatments have helped many patients avoid surgery and improve their lives dramatically. R3 has partnered with Dynamic Stem Cell Therapy to offer treatment for all types of conditions. Call (844) GET-STEM for more information and scheduling.

Regenerative medicine therapy with stem cells has become mainstream, and the pioneers at Dynamic Stem Cell Therapy are experts. The conditions treated include arthritis, tendonitis, sports injuries, ligament injuries along with a host of systemic issues such as COPD, CHF, Lupus, Rheumatoid Arthritis, Crohns Disease, Diabetes and many more.

The Las Vegas stem cell center uses the patients adipose tissue, and concentrates the stem cells in a same day treatment. The treatment is offered either as an injection or an infusion, depending on the need.

The therapy works great for helping patients avoid the need for potentially risky surgery, such as joint replacement or tendonitis surgery. Not only does the procedure include stem cells, but also growth factors along with other healing agents.

Along with the adipose stem cell therapy, the Las Vegas stem cell doctors utilize platelet rich plasma therapy, known as PRP therapy for short. The combination of the two augment the capability of repair.

In addition to bone and joint conditions along with organ issues, Dynamic offers cosmetic procedures as well. This includes the Vampire facelift along with hair restoration that works great from platelet rich plasma therapy.

Over 85% of patients benefit from the regenerative medicine procedures. Call (844) GET-STEM for more information and scheduling with the top stem cell therapy in Las Vegas.

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Cancer charity welcomes NHS u-turn on second stem cell … – The Guardian

Jeremy Hunt, the health secretary. Photograph: Dan Kitwood/Getty Images

Cancer campaigners have welcomed an NHS announcement that money may soon be available for a potentially lifesaving treatment it had previously refused to pay for.

The health service in England said on Sunday it was confident it would soon be able to announce funding for second stem cell treatments for blood cancer patients who have relapsed after an initial transfusion.

It came as the Anthony Nolan charity called on health secretary Jeremy Hunt to intervene on behalf of patients following a decision by the NHS last summer to refuse to pay for the second transfusions, saying they were more expensive and less effective than other drugs and treatments.

On Sunday night an NHS England spokeswoman: Last year medical experts ranked other new treatments as higher priority for new funding, but heading into the year beginning April 2017 we are confident the NHS will shortly be able to confirm funding for a further expansion of new treatments including second stem cell transplants.

Anthony Nolan said it was very welcome news.

Chief executive Henny Braund said: While it has tragically come too late for patients who have been denied this lifesaving treatment in the past year, this decision by NHS England will ultimately mean in future, patients and families can be reassured that they will now be able to receive the appropriate treatment should their blood cancer return.

In a poll of 1,700 people carried out by Populus on behalf of the charity, 66% of respondents said patients who relapsed after their first treatment should be given a second round, and almost half said it was unacceptable for friends or family to have to foot the bill. Almost six in 10 said the government was not doing a good enough job of making sure the NHS had the money to fund the treatments people needed.

Before the announcement, Lisa Hepburn, whose husband Gavin died last year after two attempts to get an individual request for a second stem cell treatment were rejected, said: Theres no explanation from the NHS; nothing from the heart. I feel for people who are in the situation of having to raise the money themselves. I cant believe the government can put a price on a persons life thats what they are doing.

Last week a group of charities wrote to Theresa May urging her to stop the NHS rationing treatment for people with serious illnesses and to find more money for care in next months budget.

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Cancer charity welcomes NHS u-turn on second stem cell ... - The Guardian

Stem Cell therapy is future of anti-ageing – Bangalore Mirror

Chronological aging shows the natural life cycle of the cells as opposed to cells that have been unnaturally replicated multiple times or otherwise manipulated in a lab.

In order to preserve the cells in their natural state, Penn researchers developed a system to collect and store them without manipulating them, making them available for this study. They found stem cells collected directly from human fat -- called adipose-derived stem cells (ASCs) -- can make more proteins than originally thought. This gives them the ability to replicate and maintain their stability, a finding that held true in cells collected from patients of all ages.

Our study shows these cells are very robust, even when they are collected from older patients, said Ivona Percec, MD, director of Basic Science Research in the Center for Human Appearance and the studys lead author. It also shows these cells can be potentially used safely in the future, because they require minimal manipulation and maintenance.

Stem cells are currently used in a variety of anti-aging treatments and are commonly collected from a variety of tissues. But Percecs team specifically found ASCs to be more stable than other cells, a finding that can potentially open the door to new therapies for the prevention and treatment of aging-related diseases.

Unlike other adult human stem cells, the rate at which these ASCs multiply stays consistent with age, Percec said.

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Stem Cell therapy is future of anti-ageing - Bangalore Mirror

Why the United States is no longer turning up its nose at Caribbean medical schools – STAT

M

ORENO VALLEY, Calif. Its easy to dismiss the for-profit medical schools that dot many a Caribbean island as scams, set up to woo unqualified students who rack up huge debts, drop out in staggering numbers, and if they make it to graduation end up with an all but worthless degree. Thats been the rap against them for years.

But the schools are determined to change that image. Many are quietly churning out doctors who are eager to work in poor, rural, and underserved communities. Their graduates embrace primary care and family practice, in part because theyre often shut out of training slots for more lucrative specialties.

And they just might help solve an urgent physician shortage in California and beyond.

The deans of two of the Caribbeans medical schools Ross University School of Medicine in Dominica and American University of the Caribbean in St. Maarten are on an aggressive campaign to improve their image. Theyve published a series of editorials and letterswith titles like Why malign overseas medical students? and hired public relations giant Edelman to make the case that their humble, hard-working, and compassionate students may be precisely the kinds of physicians America needs most.

Our students have persevered. They havent had all the opportunities in life and they still want to help people, said Dr. Heidi Chumley, dean of American University of the Caribbean School of Medicine. Absolutely we want to get our story out.

That story is unfolding on the ground in places like Moreno Valley, a city ofabout 200,000 in Californias Inland Empire, a former agricultural region just east of Los Angeles that grew explosively in the 80s but has since fallen on harder times.

Here, the Riverside University Health System Medical Centerrises from a stretch of largely undeveloped land once slated for luxury housing developments. The health system acts as the countys public safety net for an ethnically diverse, mostly low-income population including patients like retired carpenter Jos Luis Garcia.

On a recent clinic visit, Garcia, 69, came in to follow up on a urinary tract infection and his high blood sugar. He saw Dr. Moazzum Bajwa, 30, a second-year resident and graduate of Ross.

In a crisp white coat and bow tie, Bajwa entered the examining room and pulled up a low stool. Sitting eye to eye with Garcia, he spoke in a steady stream of fluent Spanish. The visit lasted nearly an hour.

In an attempt to keep his patient off insulin, Bajwa had asked Garcia to improve his diet and track blood sugar levels after meals. Nmeros fantsticos!, Bajwa exclaimed, looking at the folded sheet of carefully written numbers Garcia had brought to show him.

This is a very great doctor. Normally, I dont feel important.

Jos Luis Garcia, patient

Bajwa, a former middle school science teacher, then spent 10minutes drawing a careful diagram complete with neurons, intestinal walls, and red blood cells, orclulas rojas to explain to a rapt Garcia exactly why certain foods raised his blood sugar. He then examined Garcia noting he had a harmless but interesting muscle wall abnormality and checked his medical records. Was there a colonoscopy report on file? Retinal photos?

As the visit was ending, Bajwa asked Garcia about stress. Garcia said his wife had recently had surgery for glioblastoma multiforme, one of the most malignant of brain tumors. Wow, Bajwa said quietly as he quickly scanned the medical summary Garcia handed him. Wow. He sat down again on his low stool.

Lo siento mucho, seor, Bajwa said, clearly moved.

Then he gave Garcia a hug.

This is a very great doctor, Garcia said later, through a translator. Normally, I dont feel important.

Bajwa, an American citizen raised inMichigan and North Carolina, is the grandson of Pakistani Nobel physics laureate Abdus Salam and holds two advanced degrees, one in neuroanatomy and one in public health. But he couldnt get into an American medical school. So he attended Ross University in Dominica.

It was the only school that gave me an opportunity, he said.

There are some 70 medical schools throughout the Caribbean, most of them established in recent decades and run by for-profit businesses thatcater to Americans.

These so-called second chance schools accept students with poorer grades and lower MCAT scores, or sometimes no MCAT score at all. Compared to Americanmedical schools, their tuition and dropout rates are higher and their class sizes large: Ross enrolls more than 900 students per year.

Graduates can practice medicine in the United States after passing their Americanmedical licensing exams and completing a residency. But the schools have come under fire for generating a stream of students who dont end up as physicians, but do end up with crushing medical school debt because they flunk out or dont win residency spots after graduating.

Heartbreaking stories abound: One graduate of St. Georges University School of Medicine took a poor-paying job drawing blood to help pay off $400,000 in medical school loans. Another graduate of AUC entered nursing school after failing to get a residency.

Are Caribbean medical schools promising something they cannot fulfill? asked Dr. Glenn Tung, an associate dean at Brown Universitys Warren Alpert Medical School who has studied the schools. What Im concerned about is the cost to the students who dont make it and the cost to the American taxpayer when loans arent repaid.

Illinois Senator Richard Durbin, also concerned, has repeatedly introducedbipartisan legislation to strip the schools of Title IV federal funding for student loans. Three Caribbean medical schools Ross, AUC and St. Georges took in $450 million federal funding via student loans in 2012, Durbin said.

These for-profit Caribbean medical schools need to be accountable to their students and to U.S. taxpayers, he said in a statement.

Dean Chumley and Dr. Joseph Flaherty, the dean of Ross, take strong exception to such criticism.

They allow that many for-profit medical schools which have proliferated in the past few decadesbecause they are proven money makers arent doing a good job training and developing students. But they argue that AUC and Ross, two of the oldest Caribbean schools both owned by for-profit educational juggernaut DeVry Inc. are creating successful doctors.

They say they are also giving a shot to students with humble backgrounds, often minorities, who cant get near American medical schools that focus so heavily on test scores and grades.

Obviously brains help, but judgement, empathy, intuition, thats all part of it, Flaherty said. Our students are gung-ho. They want to practice medicine. Thats their dream.

Just 54 percent of American medical graduates who trained overseas are matched with a residency program for further training in their first year of eligibility. Thats an abysmal record, compared to the 94 percent of graduates of US schools who get residencies. But Ross and AUC say they have a match rates higher than 86 percent. And they say a vast majority of students pass their step 1 licensing exams on the first try.

Obviously brains help, but judgement, empathy, intuition, thats all part of it Our students are gung-ho.

Dr. Joseph Flaherty, dean of a Caribbean medical school

(Critics say the schools manipulate the statistics by dismissing weak students shortly before they are allowed to take the exams. Chumley said the schools do weed out poor students early on to prevent their accumulating debt, but in no way encourage poor students to stay for five semesters and then prevent them from taking the exam. I think thats ethically wrong, she said.)

The schools are also controversial because of their practice of buying their way into hospitals to train students. In 2012, Ross inked a contract beating out rival St. Georges University School of Medicine of Grenada to pay $35 million over a decadeto the cash strapped Kern Medical Center in Bakersfield in exchange for the lions share of the hospitals roughly 100 rotation spots for third-year medical students.

Some critics fear such deals will squeeze American-trained students out of rotations; disputes have flared in New York, where St. George paid $100 million for rotation spots, and in Texas, where lawmakers attempted to entirely ban Caribbean students from training in the state.

But Flaherty, Rosss dean, says the such deals are a win-win. A struggling hospital gets funds. His school, which has no teaching hospital, gets a place to train students. And he gets to show skeptical doctors how good his students really are.

The doctors get to know our students and say, These guys are good, he said. Our students get there early. They stay late and do extra work. They value any opportunity.

And they seize those opportunities where they can find them.

While their numbers are up, its still harder for international medical grads known as IMGs to get residency positions. Theyveheard all the jokes about studying anatomy on the beach with Mai Tais in hand. But when it comes to residency positions, they are deadly serious. For there is no practicing medicine without one.

You have to apply very widely. Theres always a stigma that IMGs dont get as good an education. said Rina Seerke-Teper, 31, a second-year resident who has wanted to be a doctor since she was six, graduated from the University of California at Berkeley and worked in stem cell research before attending AUC.

Many Caribbean graduates dont even apply to residency programs that are filled only with American trained students. Instead, they look for IMG friendly programs like the family practice residency here, run in a busy clinic housed within the county hospital. The program is highly competitive receiving about 800 applications for 12 positions each year and of the three dozen current residents, 29 studied in a medical school outside the US.

Competition for the coveted slots is likely to grow even more as California, which just got one newmedical schools and is slated to soon add another, starts spitting out more locally trained grads.

More doctors are desperately needed: California will need an estimated 8,000 additional primary care doctors by 2030. The United States as a whole is projected to need some 30,000 additional primary care physicians in coming decades.

Dr. Michelle Quiogue works in one of the areas hit hardest by the shortage rural Kern County. A graduate of a prestigious medical school at Brown University Quiogue says shes worked alongside many foreign-trained doctors and would never know what college they graduated from.

Inher mind, the problem is not a lack of medical students but a lack of residency programs to train them. The governor has proposedcutting $100 million for primary care residency training, and her organization, the California Academy of Family Physicians, is scrambling to get it replaced.

Medical school hasnt changed much in a century. Here are 5 ways to fix that

Those who do win residency spots say it seems to matter less and less where they went to school as they climb up the medical training ladder. And it seems to matter not at all in clinics where patients are grateful for any medical care they receive.

I have never heard a patient ask where a physician is trained, said Carly Barruga, a third year medical student at nearby Loma Linda University who said she is getting excellent training in her rotation here from Caribbean-trained doctors like Dr. Tavinder Singh.

Singh, 30, is chief resident here and also a graduate of Ross. While he traces his interest in medicine to the open heart surgery his grandmother had when he was a boy, Singh didnt apply to American medical schools because his MCATs werent as strong as they should have been. He didnt want to wait a year to retake them.

I had the goal in mind I was going to be a doctor, said Singh, a California native. Nothing was going to stop me. Hes loved his residency, especially the chance to work in needy communities where medical zebras unlikely and rare diagnoses can be common. You see chronic disease that have never been treated, he said. You see rare diseases like Zika.

While Singh was once the one begging for a chance, the tables have turned. In a state hungry for family practice physicians, hes now fielding numerous job offers.

Bajwas future is bright as well.

For now, though, hes just happy to be practicing medicine, thrilled to be delivering babies and focusing on preventative care. He loves helping patients like Wendy Ocampo, a 19-year-old with limb girdle muscular dystrophy. During an appointment this month, Ocampo came in to see Bajwa with respiratory symptoms.

New medical schools aim to fix Americas broken health care system

It was supposed to be a quick visit, but he ended up spending a half hour with her once he discovered bureaucratic hurdles had left her waiting seven months for the wheelchair she needs for her job and college. (Bajwa credits his clinic staff and nurses for working through lunch and juggling his schedule so he can offer longer visits.) Ocampo also hasnt been able to get the physical therapy she needs for her ankle.

It burns me up that these things are falling through the cracks, said Bajwa, after taking a few minutes to compliment Ocampos impressive new shoes and ask if she was growing out her hair.

Though sick, Ocampo beamed. Honestly, hes great, she said. He calls me to check on me. I have, like, 30 doctors and none of them have ever done that.

Correction: A previous version of this story misstated the population for Moreno Valley and the status of a proposed funding cut for residency training.

Usha Lee McFarling can be reached at usha.mcfarling@gmail.com Follow Usha Lee on Twitter @ushamcfarling

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Why the United States is no longer turning up its nose at Caribbean medical schools - STAT