Stem Cell Clinic

Gene, stem cell therapies trials underway for Parkinson's, but not in Mumbai

By Stem Cell Treatment

illustration by: Ravi Jadhav

Stem cells and gene hold promising treatment options for Parkinson's Disease, say doctors across the globe, including those in Mumbai.

Eleven trials to test stem cell and gene therapies for treating the disease are currently underway. In Mumbai, however, only two out of these 11 trials were being done resource constraints led to one being canned and regulatory hurdles have put the other one on hold.

Currently, neuro-augmentative therapies, such as usage of drugs or deep brain stimulation (DBS), are being used to treat Parkinson's Disease. "The future holds hope for neuro-restorative therapies like that of stem cells or gene infusion. Stem cells are the very primary kind of cells which can take on the function of any body part's cells after their infusion with that body part. It (the treatment) involves restoration of brain function to normal. In the next five to seven years, this may pave the way for the future," said Dr Paresh Doshi, neurologist at Jaslok Hospital on Peddar Road.

Doshi said trial of Duodopa therapy, which involves infusion of an active ingredient gel called Levodopa in the intestines, has been kept on hold. Jaslok Hospital was the only centre in the whole of Southeast Asia that was running the trial.

"Levodopa gets converted into dopamine in the body. Normal levels of dopamine control Parkinson's Disease," said Doshi.

A trial to infuse stem cells from the patient's body into the patient himself/herself had been underway in a small group of patients in India, but it had to be stopped due to the inability to recruit more patients.

Doshi said, "We could only recruit four patients for two years. However, a similar trial is underway in China and another trial, which explores adipose tissue stem cells, is underway in South Africa."

In January, medical journal The Lancet reported that after 16 years of trials, gene therapy is showing promising results in humans. "Three genes that promote the formation of dopamine-generating cells in the brain were injected in the brain, bound with a viral vector, in 15 patients. ...dopamine... becomes deficient in patients with Parkinson's," The Lancet report stated.

Three patients from the UK and 12 from France in advanced stages of Parkinson's Disease underwent an operation, wherein the virus with the three genes was injected in their brains. The patients, who had become stiff due to the disease, showed a 30% improvement in their movement after the surgery. After four years of follow-ups, they continued to improve and dopamine kept on being produced in their brain, in parts where it was not being produced before.

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Gene, stem cell therapies trials underway for Parkinson's, but not in Mumbai

Lung Institute's Innovative Stem Cell Procedure is Giving End Stage Lung Disease Patients a New Option

By Stem Cell Treatment

Tampa, Florida (PRWEB) April 10, 2014

One year ago, Gary Oberschlake was diagnosed with idiopathic pulmonary fibrosis (IPF), a deadly lung disease with no known cause characterized by the permanent scarring of lung tissue. Gary wasnt alone approximately 48,000 others received the same diagnosis last year. Claiming the lives of nearly 40,000 individuals annually, IPF is as deadly as breast cancer.

Doctors told Gary, a family man with a wife, four children, and four grandchildren, his only treatment option was a double lung transplant. Knowing the inherent risks associated with this procedure, including his bodys rejection of the new lungs, Gary refused to accept it as his only chance for survival.

After spending considerable time researching possible alternative options, Gary became fascinated by recent developments in stem cell medicine, and its potential for treating sufferers of chronic lung disease like IPF. His excitement regarding this option was met with doubt expressed by his pulmonologist, who didnt see the clinical viability of stem cells for lung conditions at the time. Despite his doctors reluctance, Gary decided to give stem cell therapy a chance.

According to his wife Debra, when he found Lung Institute in Tampa, FL, it was like it was meant to be. And, feeling as though it was a sign he couldnt ignore, Gary made the decision to pursue autologous stem cell treatment at Lung Institute in Tampa.

Today, nine months after receiving his first treatment at Lung Institute, Gary has seen results that have far exceeded his expectations, leaving his pulmonologist and cardiologist in disbelief. In fact, all the doctors he saw after his treatments have been shocked by his positive progression, which has completely changed their perspective on his prognosis and the viability of stem cells for lung disease in general.

Their astonishment at the treatments overwhelming success is not unusual many doctors like them are skeptical of the clinical application of stem cells for lung disease, simply because advancements in the field have been so recent. But skeptics need only witness the success of these treatments, as Garys doctors did, to have their position turned upside down.

Gary says prior to his stem cell treatment, his cardiologist said the next time hed see me would be in a hospital bed. Quite to the contrary, Gary is now able to enjoy many aspects of life that were previously limited by his condition. In his words, Ive been able to do things with [my grandchildren]. Before I was only able to sit down and watch them.

As a result of his refusal to accept his original prognosis, Gary and his wife are now looking into the future and planning ahead. Lung Institute continues to produce positive results, much like those experienced by Gary, and in doing so, is changing the lives of many suffering from chronic and debilitating pulmonary conditions.

About Lung Institute At Lung Institute (LI), we are changing the lives of hundreds of people across the nation through the innovative technology of regenerative medicine. We are committed to providing patients a more effective way to address pulmonary conditions and improve quality of life. Our physicians, through their designated practices, have gained worldwide recognition for the successful application of revolutionary minimally invasive stem cell therapies. With over a century of combined medical experience, our doctors have established a patient experience designed with the highest concern for patient safety and quality of care. For more information, visit our website at LungInstitute.com, like us on Facebook or call us today at 1-855-469-5864.

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Lung Institute's Innovative Stem Cell Procedure is Giving End Stage Lung Disease Patients a New Option

Scientist denies faking stem cell paper

By Stem Cell Doctors

ByElaine Kurtenbach

The Japanese scientist accused of falsifying data in a widely heralded stem cell research paper says the results are valid despite mistakes in their presentation.

Haruko Obokata, 30, struggled to maintain her composure during a televised news conference packed with hundreds of reporters, but insisted she did not tamper with the data to fabricate results. She said she did not agree with retracting the research that appeared in the scientific journal Nature.

The phenomenon of ordinary cells transforming into stem cells under the influence of external stimulus was "confirmed many times for a fact", Obokata said at the press conference in the western city of Osaka. She said she could replicate her results again if allowed back into the lab to do so.

She has contested allegations of research malpractice made by a panel of scientists at the government-funded Riken Center for Development Biology, where she is employed.

Obokata said Riken had advised her not to speak publicly about the controversy. The event Wednesday, which lasted for over two hours, was her first public appearance in weeks and was made against doctors' orders after seeking hospital treatment Monday.

"I wasn't able to sleep well and was feeling worse and worse," she said. "I take this responsibility severely. I am deeply sorry."

Obokata apologised repeatedly for having used the wrong images and having altered an image in a report on using a simple lab procedure to grow tissue for treating illnesses such as diabetes and Parkinson's disease.

In an emailed statement, Riken reiterated Obokata's right to an appeal of its findings.

"Riken will give due consideration to the appeal in accordance with our regulations," it said.

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Scientist denies faking stem cell paper

Arroyo's stem cell doctor charged with illegal practice

By Stem Cell Medical Center

The NBI says Park 'misrepresented herself as a licensed physician in several occasions'

CHARGED. The NBI files charges against an alternative medicine doctor based in Tagaytay. File photo by Buena Bernal/Rappler

MANILA, Philippines The National Bureau of Investigation (NBI) on Thursday, April 10, filed before the Tagaytay City Prosecutor's Office a case against former president Gloria Macapagal-Arroyo's stem cell physician for illegal practice of medicine.

Antonia Carandang-Park, an alternative medicine doctor based in Tagaytay City, was charged for having violated Republic Act 2382 or The Medical Act of 1959. Park is the owner and operator of the Green & Young Health & Wellness Center.

The bureau's investigation found that Park "misrepresented herself as a licensed physician [on] several occasions."

Watch this report below,

The NBI Anti-Organized and Transnational Crime Division (AOTCD) was acting on a complaint filed before the bureau by physician Eunice Salazar-Abad, who worked as an aesthetic physician with Park.

According to the NBI, Abad noticed some "irregularities" and the "unorthodox method" of treatment by Park. The NBI also found that Park, whose treatment of Arroyo gained her popularity, did not make an effort to correct news reports that referred to her as a medical doctor.

ILLEGAL PRACTICE. Dr Antonia Park in this Nov 17, 2012 photo taken by Kate Tan. Photo from Bernard Tan.

In her diagnosis of Arroyo, Park supposedly signed an official statement dated July 25, 2012 as "Dra. Antonia Park, M.D.," where she considered stem cell therapy for Arroyo, who's now under hospital arrest for plunder charges at the Veterans Memorial Medical Center in Quezon City. Mrs Arroyo is suffering from a debilitating neck and back pain.

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Arroyo's stem cell doctor charged with illegal practice

NBI files raps vs Arroyo's 'fake' stem cell doc

By Stem Cell Clinic

MANILA - The National Bureau of Investigation-Anti-Organized and Transnational Crime Division (NBI-AOTCD) has filed a case against an allegedly fake doctor who once administered stem cell therapy on former President Gloria Macapagal Arroyo.

Members of the NBI-AOCTD, headed by Head Agent Rommel J. Vallejo, acted on the complaint filed by Dr. Eunice Salazar-Abad, who worked as an aesthetic physician for Antonia Carandang-Park.

The latter is the owner of Green and Young Health and Wellness Center based in San Jose, Tagaytay City.

Vallejo said: Even for a short period of time working at the clinic, she began to notice some irregularities and the unorthodox method being applied by Park in treating the patients. She discovered too, that Park is using her name and her license number in dealing with patients.

Salazar-Abad then verified with the Professional Regulation Commission to check if Park is a licensed doctor,

Based on a document dated August 12, 2013, the PRC certified that after a diligent search, the name Antonia Carandang Park does not appear in the database of Physician, which contains the names of those duly authorized to practice medicine in the Philippines.

The document reads, this certification is issued upon request of the Board of Medicine for whatever legal purpose it may serve.

Park gained popularity when she treated Arroyo, who had been complaining of pains due to a cervical spine surgery.

Salazar-Abad noted Park did not make any effort to speak up when reports tagged her as a doctor. She said Park also misrepresented herself as an oncologist.

Vallejo said Park filed her counter-affidavit on August 22, saying she is not a quack doctor.

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NBI files raps vs Arroyo's 'fake' stem cell doc

Irvine Stem Cell Treatment Center: Public Seminar on Adipose Derived Stem Cells

By Stem Cell Treatment

Irvine, California (PRWEB) April 09, 2014

The Irvine Stem Cell Treatment Center, located in Irvine, California, announces a free public seminar on the use of stem cells for various degenerative and inflammatory conditions. They will be provided by Dr. Thomas A. Gionis, Surgeon-in-Chief.

The seminar will be held on April 13. On April 13 and will be held at 3500 Barranca Parkway, Suite 315, Irvine, CA 92606 at 2 p.m.

At the Irvine Stem Cell Treatment Center, utilizing investigational protocols, adult adipose derived stem cells (ADSCs) can be deployed to improve patients quality of life with a number of degenerative conditions and diseases. ADSCs are taken from the patients own adipose (fat) tissue (also called stromal vascular fraction (SVF). Adipose tissue is exceptionally abundant in ADSCs. The adipose tissue is obtained from the patient during a 15 minute mini-liposuction performed under local anesthesia in the doctors office. SVF is a protein-rich solution containing mononuclear cell lines (predominantly autologous mesenchymal stem cells), macrophage cells, endothelial cells, red blood cells, and important Growth Factors that facilitate the stem cell process and promote their activity.

ADSCs are the body's natural healing cells - they are recruited by chemical signals emitted by damaged tissues to repair and regenerate the bodys damaged cells. The Irvine Stem Cell Treatment Center only uses autologous stem cells from a person's own fat no embryonic stem cells are used. Our current areas of study include: Heart Failure, Emphysema, COPD, Asthma, Parkinsons Disease, Stroke, Multiple Sclerosis, and orthopedic joint injections. For more information, or if someone thinks they may be a candidate for one of the stem cell protocols offered by Irvine Stem Cell Treatment Center, they may contact Dr. Gionis directly at (949) 679-3889, or see a complete list of the Centers study areas at: http://www.StemCellsUSA.net.

About Irvine Stem Cell Treatment Center:

The Irvine Stem Cell Treatment Center is an affiliate of the Cell Surgical Network (CSN). We provide care for people suffering from diseases that may be alleviated by access to adult stem cell based regenerative treatment. We utilize a fat transfer surgical technology to isolate and implant the patients own stem cells from a small quantity of fat harvested by a mini-liposuction on the same day. The investigational protocols utilized by the Irvine Stem Cell Treatment Center have been reviewed and approved by an IRB (Institutional Review Board) which is registered with the U.S. Department of Health, Office of Human Research Protections (OHRP) and the study is registered with Clinicaltrials.gov, a service of the U.S. National Institutes of Health (NIH). For more information contact: Info(at)StemCellsUSA(dot)net or visit our website: http://www.StemCellsUSA.net.

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Irvine Stem Cell Treatment Center: Public Seminar on Adipose Derived Stem Cells

Stem Cell Therapy Could Transform Parkinson's

By Stem Cell Treatment

See Inside

Stem cell therapy is emerging as a promising treatment for Parkinson's disease

Neurosurgeon Ivar Mendez of the University of Saskatchewan often shows a video clip to demonstrate his work treating Parkinson's disease. It features a middle-aged man with this caption: Off medications. The man's face has the dull stare typical of Parkinson's. Asked to lift each hand and open and close his fingers, he barely manages. He tries but fails to get up from a chair without using his hands. When he walks, it is with the slow, shuffling gait that is another hallmark of Parkinson's, a progressive neurological disorder that afflicts an estimated one million Americans, most of them older than 60.

Then the video jumps forward in time. The same man appears, still off medications. It is now eight years since Mendez transplanted dopamine cells from a fetus into the patient's brain. These neurons, which live in a midbrain region called the substantia nigra and secrete the neurotransmitter dopamine to initiate movement, are the ones that die off in Parkinson's. The man has aged, but his energy and demeanor are characteristic of a much younger man. Asked to do the same tasks, he smoothly raises his arms high and flicks his fingers open and shut rapidly. Arms crossed on his chest, he rises from a chair with apparent ease. Then he struts down the hall.

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Stem Cell Therapy Could Transform Parkinson's

National Stem Cell Coordinating Centre Launched

By Stem Cell Treatment

KUALA LUMPUR, April 10 (Bernama) - The Ministry of Health finally realised its wish to have a National Stem Cell Coordinating Centre (NSCCC) which was launched Thursday.

Director of Medical Development Division, Datuk Dr Azmi Shapie said the NSCCC was built at a mere cost of RM50,000 using the expertise from its own staff.

"I hope the existence of the NSCCC can benefit patients in dire need of stem cell treatment," he told reporters after launching the NSCCC at the National Blood Centre here, on behalf of the director-general of Health, Datuk Dr Noor Hisham Abdullah.

In a statement distributed to reporters, Dr Noor Hisham said stem cells could only be obtained from blood vessels, bone marrow or umbilical cord blood to produce different types of blood components needed to treat patients.

It said all Malaysians aged 18 to 50 years who are healthy and free from infectious diseases and chronic diseases are encouraged to register as cell donors.

Among the diseases that may be treated with stem cell blood transplant are leukemia, lymphoma, thalassemia and aplastic anemia.

Statistics (from 2006 to March 31) show that 22,933 Malaysians or 0.08 per cent of the total population registered as stem cell donors in the Malaysian Stem Cell Registry.

Also launched at the event was a book of guidelines on the policies and procedures to ensure that the stem cell donation process meet professional ethics.

-- BERNAMA

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National Stem Cell Coordinating Centre Launched

Japan stem cell researcher says results valid – Quincy Herald-Whig | Illinois & Missouri News, Sports

By Stem Cell Doctors

By ELAINE KURTENBACH AP Business Writer

TOKYO (AP) - The Japanese scientist accused of falsifying data in a widely heralded stem-cell research paper said Wednesday the results are valid despite mistakes in their presentation.

Haruko Obokata, 30, struggled to maintain her composure during a televised news conference packed with hundreds of reporters, but insisted she did not tamper with the data to fabricate results. She said she did not agree with retracting the research that appeared in the scientific journal Nature.

The phenomenon of ordinary cells transforming into stem cells under the influence of external stimulus was "confirmed many times for a fact," Obokata said at the press conference in the western city of Osaka. She said she could replicate her results again if allowed back into the lab to do so.

She has contested allegations of research malpractice made by a panel of scientists at the government-funded Riken Center for Development Biology, where she is employed.

Obokata said Riken had advised her not to speak publicly about the controversy. The event Wednesday, which lasted for over two hours, was her first public appearance in weeks and was made against doctors' orders after seeking hospital treatment Monday.

"I wasn't able to sleep well and was feeling worse and worse," she said. "I take this responsibility severely. I am deeply sorry."

Obokata apologized repeatedly for having used the wrong images and having altered an image in a report on using a simple lab procedure to grow tissue for treating illnesses such as diabetes and Parkinson's disease.

In an emailed statement, Riken reiterated Obokata's right to an appeal of its findings.

"Riken will give due consideration to the appeal in accordance with our regulations," it said.

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Japan stem cell researcher says results valid - Quincy Herald-Whig | Illinois & Missouri News, Sports

Stem Cells and Regenerative Medicine | UNMC

By Stem Cell Medicine

Regenerative Medicine encompasses many fields of science and medicine. The image below effectively portrays the scope of Regenerative Medicine; as the umbrella, it covers many fields of research and clinical practice. Stem cell research and therapies continue to enhance the field of Regenerative Medicine and what it offers patients and scientists. Stem cells have and will continue to play a critical role in scientific discoveries through developmental biology and therapeutic applications, however, we should be mindful to not limit our descriptions or thoughts regarding Regenerative Medicine and its capabilities to stem cell research alone. The only constraints placed around it are the ones we set, as those in the field seek to uncover the intricacies of our biological systems.

STEM CELLS

Typically, when the term Regenerative Medicine arises people automatically think about stem cells, particularly, embryonic stem cells. Being that embryonic stem cell research is currently a highly debated topic in both the scientific and political field, the assumption that Regenerative Medicine Research only involves embryonic stem cell research can be narrowing to the field and does not allow one to understand its full potential. While all stem cell work is vital to the advancement of Regenerative Medicine research and therapies, we cannot interchange the two terms as equals. As we learn more about Regenerative Medicine, we must broaden our minds, so as not to limit the vast possibilities that Regenerative Medicine researchers seek to find in the inherent mysteries of our biological systems.

How are stem cells and Regenerative Medicine linked?

As discussed in other portions of this site, Regenerative Medicine is a comprehensive term used to describe the current methods and research employed to revive and/or replace dead or damaged tissue. A portion of Regenerative Medicine research revolves around the use of stem cells, including embryonic, adult, and induced pluripotent stem cells (iPS), however there are many other resources that are utilized in order to carry out the mission of Regenerative Medicine research. These include transplants, biomaterials, scaffolds, machines and electronics, stimulation pathways, drug therapy, and many others. This is thoroughly discussed on the What is Regenerative Medicine? page.

Stem cells have a very important role in Regenerative Medicine Research and have many potential applications. First, because of their role in development and their potential to develop into many different cells types, stem cells are vital to the field of developmental biology. Developmental biologists seek to uncover what genes and pathways are involved in cell differentiation (how cells develop into specific cell types such as liver, skin, or muscle cells) and how these can be manipulated to create new healthy tissues. Second, stem cells can be applied to drug testing and development. New drugs that are developed in Pharma could be safely and effectively tested using differentiated stem cells. As scientists learn more about how stem cells develop to form new tissue they will be able to apply their knowledge in maintaining differentiated cell types that can be used to test particular drugs. This method is already underway in the cancer therapy world, where cancer cells and grown in the laboratory for the purpose of testing anti-tumor and chemotherapeutic drugs. Finally, and of most interest to patients and scientists is the role stem cells will play in Cell-Based Therapy. These therapies will apply the understanding of stem cell development, differentiation, and maintenance to generate new, healthy tissue for diseases needing transplant or replacement of damaged tissue, such as arthritis, Parkinson's disease, type 1 diabetes, and coronary disease. Cell therapies may one day be able to replace organ donation and eliminate the issues that accompany it such as rejection and tissue insufficiency. Although there are still many difficulties surrounding the field of stem cell research and therapy, over the coming decades scientists hope to continue to make discoveries that will enable the potentials of cell-based therapy to become a reality.

Learn more about Stem Cells on UNMC's Stem Cell site.

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Stem Cells and Regenerative Medicine | UNMC

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