Stem Cell Clinic

4th World Congress on Cell Science & Stem Cell Research to Exploit the Latest Advancements

By Stem Cell Treatment

Henderson, Nevada (PRWEB) March 18, 2014

According to Dr. Srinubabu Gedela, the Managing Director of OMICS Publishing Group , the main aim of the Cell Science-2014 is to broadening the scope of the research in this field.

The OMICS Group Conferences 4th world congress on Cell Science & Stem Cell Research deliberates on the broader areas of Evolution of cancer, Tumorogenesis, Recombinant DNA technology, Cancer cell development and signaling pathway, Genetic engineering and Gene therapy, Tumor suppressor genes, Tissue Engineering, Stem cell treatment, Bioinformatics and Computational biology, Bio Ethics and Patent Rights.

Reputed speakers at the Cell Science-2014, an international medical conference 2014, including Stewart Sell of University of Albany, USA, Sudhakar Akul Yakkanti, SRI International, USA, Jimmy Thomas Efrid, Brody School of Medicine, USA and Diana Anderson, University of Bradford, UK are going to share their experiences in this field.

OMICS Group International, an open access publisher that publishes 300 online, peer reviewed science journals in the fields of Clinical, Medical, Engineering and technological, Pharmaceutical and Management fields also organizes more than 100 international science conferences and events across the globe. With the help of more than 150 scientific associations with the like-minded organization, OMICS Group is contributing for the dissemination of scientific knowledge and information.

Soraya L. Valles Professor of Phisiology ar tht University of Valencia, Spain organized pre-conference workshop for the Cell Sceince-2014 on Neuro Sceince on 25th February at Salon de Grados, Faculty of Medicine Valencia, Spain.

James L. Sharely, Director at The Adult Stem Cell Technology Centre, LLC, USA presents a symposium at this OMICS Group World Congress on the topic Stem Cell DNA Segregation and Genetic Fidelity. Ornella Parolini, President, International Placenta Stem Cell Research (IPLASS) also presents another symposium on Fetal-derived Stem cells: Characteristics and Applications

The Young Researchers Forum at Cell Sceince-2014 provides the Young Researchers/Investigators an opportunity to present their latest research projects with an in-depth analysis. Student fellowships and the best poster awards for an outstanding poster presentation benefit the student community.

The OMICS Group World Congress on Cell Science & Stem Cell Research is all set to provide a comprehensive view of this discipline in a nutshell.

For more information on the subject of this release: http://www.conferenceseries.net/cell-science-stem-cell-research-congress-2014/

View post:
4th World Congress on Cell Science & Stem Cell Research to Exploit the Latest Advancements

A Study of Protein Synthesis In Stem Cells Conducted For The First Time

By Stem Cell Medical Center

By Liisa Vexler

Scientists at the Children's Medical Center Research Institute, UT Southwestern Medical Center, Texas, have conducted a breakthrough piece of research into protein synthesis in adult stem cells. The research, previously not possible to conduct, has linked certain cancers with mutations affecting protein synthesis.

The process used an antibiotic called puromycin, in modified form, to aid in measuring the quantity of protein synthesized in the body. Research revealed that protein is produced at a different rate per hour for different types of blood cells. It was also noted that much lower amounts of protein are synthesized by stem cells than other cells (blood-forming). The research, conducted on mice, concluded that when ribosome, a genetic mutation involved in making protein, was present the production of protein in stem cells diminished by 30%. Conversely, in another experiment the tumor-suppressor gene P-ten was removed in an attempt to increase protein synthesis, resulting in an impairment of stem cell function. These findings conclude that protein synthesis for blood forming stem cells needs to be well regulated or else they will not function efficiently. A member of the team, Dr. Morrison, observed to his amazement that breeding Pten mutant mice with ribosomal mutant mice returned stem cell function to normal, leading to either a complete block or delay on the development of Leukaemia. Dr. Morrison is of the view that, all of this happened because protein production in stem cells was returned to normal. It was as if two wrongs made a right. The findings are thought to open the door to a number of similar tests for the many kinds of cells in the human body, making it possible to study protein synthesis for each. The research is thought to be important for understanding the differences in the rates and ways that protein in synthesized in cells and what this means for cellular survival.

Read the original post:
A Study of Protein Synthesis In Stem Cells Conducted For The First Time

Researchers find stem cells remember prior substrates

By Stem Cell Medical Center

6 hours ago by Bob Yirka Mesenchymal stem cell displaying typical ultrastructural characteristics. Credit: Robert M. Hunt/Wikipedia

(Phys.org) A team of researchers working at the University of Colorado has found that human stem cells appear to remember the physical nature of the structure they were grown on, after being moved to a different substrate. In their paper published in the journal Nature Materials, the researchers describe how they grew human stem cells on different substrates. In so doing, they discovered that the stem cells continued to express certain proteins related to a substrate even after its hardness was changed.

Scientists have known for some time that stem cells respond to their environment as they growthose grown on hard material, such as glass or metal for example, are more amenable to growing into bone cells. In this new effort, the researchers sought to discover if changes to a stem cell brought about by environment are retained if the stem cell is moved to a different environment.

To find out, the researchers used mesenchymal cells which are known to be able to grow into almost any human body part. They placed the stem cells on a stiff substrate then moved them to one less stiff over differing numbers of days. In so doing, they found that the longer the cells were left on the stiff substrate the more a protein connected to bone growth (RUNX2) was expressed. Conversely, cells that were first placed on a soft surface and subsequently moved to a hard surface demonstrated a tendency to develop either bone or adipogenic tendencies.

In another experiment, the researchers applied the stem cells to a substrate coated with a phototunable hydrogelit grows softer when exposed to lightusing it allowed for changing the stiffness of the substrate without having to move the cells. Using this approach the team found that if the cells were allowed to grow on the gel in its stiff state, for just one day, switching to a soft state caused the expression of RUNX2 to cease immediately. When they allowed the cells to grow for ten days on the stiff base, however, before switching to a soft one, expression of RUNX2 continued for another ten days before finally ceasing. This shows, the researchers contend, that stem cells have a memory component that is not yet understood.

The researchers note that their findings could be applied to other stem cell research areas such as cases where unintentional consequences may be arising in experiments due to the stiffness of the substrate in which they are being grown. It also raises the question of whether other environmental factors might be impacting cell growth and if so, if they have a memory component as well.

Explore further: Heart cells respond to stiff environments

More information: Mechanical memory and dosing influence stem cell fate, Nature Materials (2014) DOI: 10.1038/nmat3889

Abstract We investigated whether stem cells remember past physical signals and whether these can be exploited to dose cells mechanically. We found that the activation of the Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding domain (TAZ) as well as the pre-osteogenic transcription factor RUNX2 in human mesenchymal stem cells (hMSCs) cultured on soft poly(ethylene glycol) (PEG) hydrogels (Young's modulus E ~ 2 kPa) depended on previous culture time on stiff tissue culture polystyrene (TCPS; E ~ 3 GPa). In addition, mechanical dosing of hMSCs cultured on initially stiff (E ~ 10 kPa) and then soft (E ~ 2 kPa) phototunable PEG hydrogels resulted in either reversible orabove a threshold mechanical doseirreversible activation of YAP/TAZ and RUNX2. We also found that increased mechanical dosing on supraphysiologically stiff TCPS biases hMSCs towards osteogenic differentiation. We conclude that stem cells possess mechanical memorywith YAP/TAZ acting as an intracellular mechanical rheostatthat stores information from past physical environments and influences the cells' fate.

Journal reference: Nature Materials

Read more:
Researchers find stem cells remember prior substrates

Registration of PH stem cell group revoked

By Uncategorized

MANILA - The Securities and Exchange Commission (SEC) revoked the corporate registration of the Philippine Society for Stem Cell Medicine (PSSCM) for submitting fabricated endorsement from the Professional Regulation Commission (PRC).

In a five-page order, SEC acting director Ferdinand Sales said the PSSCM committed fraud in procuring its Certificate of Incorporation.

He said that as required under Section 17 of the Corporation Code, the PSSCM submitted a favorable endorsement from the PRC to support its application for corporate registration.

But he said the SEC found that the 2nd PRC Indorsement dated Feb. 20, 2013 submitted by PSSCM was falsified.

Considering the submission of a falsified PRC endorsement, there is fraud in procurement of respondents certificate of registration. The falsified document was relied upon by this Commission in approving the registration application of the respondent, Sales noted.

He added that had the SEC known about such defect early on, it would have not accepted and approved the registration application of the respondent.

Link:
Registration of PH stem cell group revoked

PMA head, 4 other doctors probed by PRC over alleged fraud, forgery

By Uncategorized

MANILA, Philippines The president of the Philippine Medical Association (PMA) and his four predecessors have been slapped with ethics cases before the Professional Regulation Commission (PRC) for alleged fraud in the registration of the Philippine Society for Stem Cell Medicine (PSSCM) in the Securities and Exchange Commission.

In a statement on Sunday, PRC Chair Teresita Manzala said she has directed the Professional Regulatory Board of Medicine (PRBOM) to file cases against doctors Leo Olarte, Bu Castro, Rey Melchor Santos, Oscar Tinio and Jose Sabili for forging her signature in the incorporation of the PSSCM.

The Commission directed the PRBOM to initiate the filing of a case of unprofessional, dishonorable and unethical conduct against the five incorporators, said Manzala, adding that a case was already pending before the PRC legal division.

Olarte, Castro, Santos, Tinio and Sabili were identified as the incorporators of the PSSCM, whose registration has been revoked by the SEC.

Investigation showed the doctors submitted an application to the SEC for the corporations registration in February 2013. As part of the procedure, PRBOM sent a communication to the five incorporators requiring them to submit pertinent documents but did not receive any response from the doctors. Without the documents, the PRBOM instead placed the application papers on hold. It never submitted the application papers and the required PRC endorsement to the SEC for final approval, said Manzala.

But several months later, the board received information that the PSSCM was able to register with the SEC, based on an endorsement signed by the PRC chair.

On examination of the supposed PRC endorsement, it was noted that the reference regulatory law used was the Philippine Veterinary Law of 2004, instead ofthe Medical Act of 1959, and there appeared a signature of the PRC chair, she said.

Manzala said three of the incorporators, whom she did not identify, denied participation in obtaining the SEC registration and pointed to Dr. Mike Aragon, the PMA spokesperson, as the one responsible for registering the organization at SEC.

In a notarized affidavit submitted to the PRBOM, Aragon admitted he was appointed to register the corporation at SEC but added that he paid P15,000 to a trading company to file the necessary documents needed for the incorporation of PSSCM. He denied involvement in the actual processing of the SEC papers after making the payment.

Manzala submitted a complaint to the SEC, charging her signature was forged in August 2013.

Go here to see the original:
PMA head, 4 other doctors probed by PRC over alleged fraud, forgery

Doctors charged with fraud

By Stem Cell Doctors

Teresita Manzala, chair of the Professional Regulations Commission (PRC), has accused five prominent doctors of committing fraud to secure approval for a corporation that they set up.

Leo Olarte, Bu Castro, Rey Melchor Santos, Oscar Tinio and Jose Asa Sabili allegedly forged Manzalas signature so their corporation could be approved by the Securities and Exchange Commission (SEC).

Olarte is the current president of the Philippine Medical Association (PMA), while the others are past presidents of the group.

The SEC has revoked the registration of the Philippine Society for Stem Cell Medicine Inc. (PSSCM), the company the five doctors registered.

Criminal and administrative charges may be filed against Olarte et al. for allegedly forging the PRC heads signature.

PSSCMs stated purpose is to organize and operate an organization that will advocate the development and propagation of stem cell technology, including but not limited to information dissemination, research, fora, seminars and other related activities to support the above-mentioned.

After receiving the PSSCM application, the SEC asked its incorporators to submit a favorable endorsement from the PRC because of the medical nature of the proposed company.

Complying with the SEC order, the incorporators submitted a document which bore the signature presumed to be that of PRC Chair Manzala.

The document states the PRC went over the provisions of PSSCMs articles of incorporation and found these consistent with the PRC Modernization Law of 2000.

On the basis of the alleged endorsement, the SEC approved the application.

Read this article:
Doctors charged with fraud

Nobel laureate calls handing of stem cell research data 'sloppy'

By Stem Cell Medical Center

The Nobel Prize-winning head of a Japanese institute whose scientists' work on stem cells was hailed as a game-changer in the field of medical biology called the lead researcher's handling of the data "extremely sloppy" and "irresponsible".

Two papers published in the journal Nature in January detailed a simple way to reprogram mature animal cells back into an embryonic-like state that allows them to generate many types of tissue, offering hope for a simpler way to replace damaged cells or grow new organs in humans.

But other scientists have been unable to replicate the research's results since then and there have been indications of problems with its data and images.

"The problem here is one immature researcher collected a huge amount of research data, and her handling of data was extremely sloppy and irresponsible," president of Japanese research institute RIKEN Ryoji Noyori told a news conference.

"I would like to offer my apology for the Nature articles, having brought into question the credibility of the science community," said Noyori, bowing deeply.

Noyori, who won a Nobel prize for chemistry in 2001, was referring to Haruko Obokata, 30, a lead author of the papers who became an instant celebrity in Japan after they were published.

A written statement from Obokata and two other RIKEN researchers made available at the news conference said they are discussing the possible withdrawal of the papers with other co-authors.

Another scientist on the team, Teruhiko Wakayama of the University of Yamanashi, has already called for the papers to be withdrawn.

"It is no longer clear what's right," Wakayama told public broadcaster NHK on Monday.

The news conference was called to release the interim findings of investigation on the controversy by a panel of experts from within and outside RIKEN.

Read more from the original source:
Nobel laureate calls handing of stem cell research data 'sloppy'

Fairfield vet hospital performs stem cell treatments

By Stem Cell Treatment

A Fairfield veterinary hospital is using stem cell treatment to help ailing dogs suffering from joint pain and even hip dysplasia.

Officials said Woodridge Veterinary Hospital is one of the few places that have performed these procedures.

On Friday Bosco, an 11-year-old Labrador, was in for surgery on his arthritic knees.

Doctors took fat out of Bosco, extracted the stem cells and then injected the stem cells back into Boscos knees.

Doctors said Bosco will have a little bit of swelling after the procedure but in four or five weeks he should be feeling much better.

Dr. Roberto Legorreta explained how stem cells are naturally used in the body.

"Every time that a trauma happens or anything that happens in our body, the stems cells are what get activated to regenerate that tissue. That's how we heal," Legorreta said.

Legorreta touched on the importance of this procedure and the excitement that goes along with it.

"I think this is the future of medicine, truly, in many many ways, and we're glad to be at the forefront of that, Legorreta said.

Read more here:
Fairfield vet hospital performs stem cell treatments

FDA's Regulation of Regenerative Medicine including Stem Cell Treatments, Tissue Engineering, Etc.

By Stem Cell Medicine

Course Description: Regenerative medicine focuses on harnessing the power of ones own stem cells and regenerative capabilities to restore function to damaged cells, tissues and organs. In April 2006, the U.S. Food and Drug Administrations (FDA) implemented regulations governing the use of human cells, tissues, and cellular and tissue-based products (HCT/Ps) in humans including bone, ligament, skin, dura mater, stem cells, cartilage cells, and various other cellular and tissue-based products. Currently, there is an ongoing debate in the industry on how such therapies should be regulated by FDA or under the practice of medicine, under federal law or state law, and as drugs or simply biologics.

This 2-day interactive seminar on FDA regulations of regenerative medicine will cover:

-How FDA is currently regulating regenerative therapies and products intended for both human and veterinary use. -The distinction being made between human regenerative products and their regulation as drugs, biologics, devices, and combination products. -The New Drug Application (NDA) and the Biologic License Application (BLA) review and approval processes including a discussion of available options, application components, relevant meetings, timing, costs and approval requirements. -The option for obtaining designation and approval as Orphan Drug Product. -Designing and conducting appropriate clinical trials to support the approval of regenerative therapies. -FDAs regulation of some regenerative medicine products and accessories as Medical Devices. -The Current Good Manufacturing Practices (cGMPs) and Good Laboratory Practices (GLPs) being applied by FDA to human regenerative products. -The labeling and marketing of regenerative products and therapies. -The potential for enforcement action and recommendations for mitigating that risk. -The current regulation of veterinary cellular treatments including autologous, allogeneic and xenogeneic cellular products in the United States.

Learning Objectives: Participants who attend this course on FDA regulation of regenerative medicines will leave with a comprehensive understanding of:

-How FDA regulates regenerative treatments and therapies? -The HCT/P Criteria and Minimal Manipulation Standard. -The Drug and Biological Approval Process. -Regenerative Products as Medical Devices. -How to Design Appropriate Clinical Trials? -Applicable cGMPs and cGLPs. -Marketing Exclusivity and Patent Restoration. -Product Labeling, Marketing and Advertising. -FDA and other Federal Agency Enforcement Action. -The Regulation of Veterinary Regenerative Medicine. -The New Animal Drug Application (NADA) Process. -Veterinary User Fees and Waivers.

Who will benefit: This course is designed for professionals in stem cell, biotech, pharmaceutical and animal drug companies, veterinary hospitals and clinics. The following personnel will find this session valuable:

-Senior quality managers -Quality professionals -Regulatory professionals -Compliance professionals -Production supervisors -Manufacturing engineers -Production engineers -Design engineers -Labelers and Private Labelers -Contract Manufacturers -Importers and Custom Agents -U.S. Agents of Foreign Corporations -Process owners -Quality engineers -Quality auditors -Document control specialists -Record retention specialists -Medical affairs -Legal Professionals -Financial Advisors and Institutional Investors -Consultants, Inspectors and cGMP Experts

Read more:
FDA's Regulation of Regenerative Medicine including Stem Cell Treatments, Tissue Engineering, Etc.

→←