Alzheimer’s study shows improved memory and mood with … – Drug Target Review

Using rodent models, the researchers emphasized the potential of newly generated neurons in adulthood to serve as therapy for addressing the functional deficits and pathology associated with Alzheimers disease.

In adult human brains, the hippocampus generates new neurons (adult-born neurons, or ABNs) throughout life, helping to maintain memories and regulate emotions. Scientists call this process adult hippocampus neurogenesis (AHN). In people with Alzheimers disease, this process is impaired, leading to reduced production of ABNs with poorer qualities. Given that Alzheimers patients often develop both cognitive symptoms (such as memory loss) and non-cognitive symptoms (such as anxiety and depression) for which AHN plays a critical role, one way to help Alzheimers patients achieve symptom relief could be to restore AHN.

Published in the journal Cell Stem Cell, scientists from University in Chapel Hill School of Medicine, US, demonstrated that stimulating a brain region called Supramammilary nucleus (SuM) located in the hypothalamus effectively enhanced adult-born neurons in the otherwise impaired Alzheimers brains of mice. After patterned stimulation of SuM, Alzheimers brains developed more ABNs with improved qualities. Importantly, activation of these SuM-modified ABNs restored both cognitive and affective deficits in Alzheimers mouse models.

It has been a longstanding question whether AHN can be sufficiently enhanced in impaired Alzheimers brains to improve brain function, said senior author Dr Juan Song. An important point to consider when addressing these questions is the low-level hippocampal neurogenesis, which becomes even lower in Alzheimers patients.

By manipulating a small number of ABNs in the Alzheimers brain, we demonstrate that ABNs can be enhanced even in the presence of Alzheimers pathology, and these enhanced ABNs are important for the restoration of behaviours and hippocampal function.

To enhance ABNs in Alzheimers brains, Song and colleagues adopted an elegant two-step ABN-enhancing strategy by first stimulating SuM using a patterned optogenetic paradigm with the goal of promoting the generation and developmental properties of ABNs, followed by stimulating the activity of SuM-enhanced ABNs using chemogenetics.

Optogenetics involves the use of light to alter the activity of brain cells expressing light-sensitive opsin genes. Chemogenetics involves the use of inert molecules to alter the activity of brain cells expressing designers receptors.

Interestingly, SuM stimulation alone or activation of ABNs without SuM stimulation failed to restore behavioural deficits in Alzheimers mice. Song said. These results suggest that multi-level enhancement of ABNs namely increasing their number, improving their developmental properties, and enhancing their activity is required to achieve their therapeutic benefits in Alzheimers brains.

When Song and colleagues further analysed the protein changes in the hippocampus of Alzheimers mice in response to activation of SuM-enhanced ABNs, the researchers found that several well-known protein pathways were activated inside cells. These pathways include the ones important for synaptic plasticity of neuronal cells that allow enhanced communication among them, as well as the ones important for phagocytosis of non-neuronal microglia that allow efficient plaque clearance.

It is striking that multi-level enhancement of ABNs through combined SuM and ABN stimulations allows such a small number of ABNs make profound functional contribution in diseased Alzheimers brains, Song said. We are eager to find out the mechanisms underlying these beneficial effects mediated by activation of SuM-enhanced ABNs on Alzheimers pathology and hippocampal function. Future efforts will be needed to develop drugs that mimic these beneficial effects mediated by activation of SuM-enhanced ABNs. Ultimately, the hope is to develop first-in-class, highly targeted therapies to treat Alzheimers and related dementia.

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Alzheimer's study shows improved memory and mood with ... - Drug Target Review

Biden Weaponized Health Care on Abortion, Transgender, COVID-19 – Daily Signal

FIRST ON THE DAILY SIGNALA coalition of conservative leaders and former federal government political appointees has compiled a game plan for the next conservative president to restore the Department of Health and Human Services to a focus on health care rather than forcing a leftist agenda down Americans throats.

From the COVID-19 pandemic to abortion funding and transgender mandates, HHS has twisted federal law and the pursuit of public health to marginalize people of faith and promote bureaucrats and leftist activism, warns a report edited by Roger Severino, former director of the HHS Office of Civil Rights under President Donald Trump. He argues that the next conservative president must reverse these abuses and return HHS to its proper role: the promotion of public health.

Few areas of life are more important, and more subject to abuse, than public health, Severino, vice president of Domestic Policy at The Heritage Foundation, told The Daily Signal in a statement Monday. Unfortunately, our public health agencies have replaced science and medicine with politics and ideology, and Americans now face shorter life spans as a result. Reform can only happen if entrenched special interests, from lawless bureaucratic leaders and Big Pharma, are reined in and rooted out. (The Daily Signal is The Heritage Foundations news outlet.)

Severino organized and edited a major report in the book Mandate for Leadership, compiled by the 2025 Presidential Transition Project, noting that after the COVID-19 pandemic was over, U.S. life expectancy continued to drop precipitously. A copy of the report on HHS was provided exclusively toThe Daily Signalfor this article.

The Heritage Foundation helped launch the 2025 Presidential Transition Project (also known as Project 2025) to equip a potential conservative president to govern effectively from Day One.

HHS has an outsized impact on the federal government, from its role in declaring public health emergencies to its management of Medicare and Medicaid to its $1.6 trillion annual budget. Under Presidents Joe Biden and Barack Obama, HHS has also used its power over health policy to promote abortion and transgender ideology.

Severinos team lays out five overarching goals for a conservative president intent on reshaping HHS: (1) protecting life from conception, protecting the rights of conscience of health care workers, and defending biological reality against gender identity ideology; (2) empowering patients to make their own health care choices, enabling providers to offer more options, and unleashing markets to drive down costs and improve quality; (3) promoting stable and flourishing married families instead of LGBT activism and single motherhood; (4) correcting the errors of the COVID-19 pandemic and preparing for the next health emergency; and (5) closing the revolving door between government and Big Pharma, where regulators leave government and work for companies they have regulated and pharmaceutical executives move from industry into regulatory agencies.

Severinos team breaks down the massive bureaucracy of HHS and presents specific recommendations for each branch of the behemoth agency. This article focuses on a few of the specific issues that motivate the major changes he recommends.

Many of the reports critiques and recommendations for a future HHS trace back to the departments abuses during the COVID-19 pandemic. It notes that while the HHS secretary declared a public health emergency, the threshold for what constitutes a public health emergencyhow many cases, hospitalizations, deaths, etc.was never defined.

Severinos team recommends that Congress restrict HHSs ability to declare indefinite public health emergencies, in part by establishing a set time frame for any emergency.

The report also recommends that the HHS secretary investigate, expose, and remediate any instances in which HHS violated peoples rights by colluding with Big Tech companies to silence dissent on COVID-19.

Severinos team says the Centers for Disease Control and Prevention should be broken up into two separate organizations: one dedicated to gathering scientific data and one responsible for making public health recommendationsan inescapably political function. The report notes that the CDC previously held back public health information on COVID-19 partially due to fear that the information might be misinterpreted.

CDC should report on the risks and effectiveness of all infectious disease-mitigation measures dispassionately and leave the should and must policy calls to politically accountable parties, the report suggests. Congress should ensure that CDCs legal authorities are clearly defined and limited to prevent an arbitrary and vacillating exercise of power, as the U.S. experienced during the pandemic.

Severinos report recommends that the Food and Drug Administration, not the CDC, should regulate vaccines, and calls for reforms to prevent the National Institutes of Healths inappropriate industry ties that create serious conflicts of interest.

The report notes that the National Institute of Allergy and Infectious DiseasesAnthony Faucis division of the NIHowns half of the patent for the Moderna COVID-19 vaccine, among thousands of other pharma patents. According to NIH documents, NIH Director Francis Collins, Fauci, and Faucis deputy director, Clifford Lane, all received royalty payments from pharmaceutical companies between 2009 and 2014.

The report faults NIH for funding gain-of-function viral research that may have been responsible for COVID-19.

Severinos team recommends HHS change many policies to protect unborn life and maternal health and to honor the religious convictions of Americans who object to the use of aborted baby body parts in medical research.

The CDC should fund studies into the risks and complications of abortion and require states to report abortion complications and babies born alive despite an attempted abortion, the team writes. It should prohibit research on aborted baby body parts, since such research can be easily replaced with research on adult stem cells. And it should avoid promoting abortion as health care.

The report condemns the CDCs current abortion and maternal mortality reporting systems as woefully inadequate, since states provide those statistics on a voluntary basis. Because liberal states have now become sanctuaries for abortion tourism, HHS should use every available tool, including the cutting of funds, to ensure that every state reports exactly how many abortions take place within its borders, at what gestational age of the child, for what reason, the mothers state of residence, and by what method.

Severinos team urges the FDA to reconsider its approval of chemical abortion drugs, an approval that currently faces a court challenge. The report notes that the complication rater for chemical abortion is four times higher than that of surgical abortion and that the chemical abortion drug mifepristone has been associated with 26 deaths of pregnant mothers, over 1,000 hospitalizations, and thousands more adverse events. It also calls the approval of this drug politicized and illegal from the start.

The report also calls for the FDA to loosen its restrictions on foreign-made vaccines that were not derived through or tested on aborted baby cells, reinstituting a Trump-era waiver for Japanese-made vaccines.

It urges the Centers for Medicare and Medicaid Services to block Planned Parenthood from receiving Medicaid funds and to redirect funds to health centers that provide real health care for women.

Severinos team urges HHS to audit the Centers for Medicare and Medicaid Services for compliance to the Hyde Amendment, which prevents federal funding of abortions, and to perform a full review of HHS efforts to promote abortion in the wake of the Supreme Courts overturning Roe v. Wade.

The report also urges various HHS departments to rescind ideologically motivated fearmongering guidance that the Biden administration released in the wake of the courts ruling, such as warnings about state governments targeting women for getting abortions.

Radical actors inside and outside government are promoting harmful identity politics that replaces biological sex with subjective notions of gender identity,' Severinos team warns. The report urges a potential conservative president to reverse this trend.

Bidens HHS has interpreted Section 1557 of the Affordable Care Act (also known as Obamacare), which prohibits discrimination on the basis of sex in health care, to forbid discrimination on the basis of gender identity and sexual orientation as well. Severinos team urges a future HHS secretary to explicitly revoke this guidance, as HHS did under Trump.

The report says that the Centers for Medicare and Medicaid Services should reissue and expand upon its 2016 decision that it cannot recommend gender reassignment surgery for Medicare beneficiaries, citing the growing body of evidence that such interventions are dangerous. (Many doctors recently testified in favor of a Florida rule blocking Medicaid coverage for experimental transgender interventions.)

The report also urges HHS to withdraw guidance allowing taxpayer funds to pay for cross-sex transitions.

It faults the NIH for having been at the forefront in pushing junk gender science, and encourages the agency to fund studies into the short-term and long-term negative effects of [cross-sex] interventions, including affirmation, puberty blockers, cross-sex hormones and surgeries, and the likelihood of desistence [abandoning the desire to change ones sex] if young people are given counseling that does not include medical or social interventions.

Severinos team notes that under liberal administrations, the office of HHS that he led, the Office for Civil Rights, has amassed a poor record of devoting resources to conscience and religious freedom enforcement and is often complicit in approving or looking the other way at the administrations own attacks on religious liberty.

The report encourages a prospective conservative president to direct the Office for Civil Rights to return to the Trump-era policies that initiated robust enforcement of these conscience laws. It urges HHS to reestablish waivers for state and child welfare agencies, especially for faith-based adoption and foster care agencies, which had previously been excluded from federal programs because they were unwilling to place children with same-sex couples.

Severinos team warns that Medicare and Medicaid operate runaway entitlements that stifle medical innovation, encourage fraud, and impede cost containment, in addition to which their fiscal future is in peril.

The report urges the Centers for Medicare and Medicaid Services to increase Medicare beneficiaries control over their own care; reduce regulatory burdens on doctors; ensure sustainability and value for both beneficiaries and taxpayers; and reduce fraud, waste, and abuse. It favors Medicare Advantage and urges Medicare to pay the same amount for outpatient procedures that it does for inpatient hospital services. It also encourages Medicare to reform payments along the lines of intensity and value of service, as opposed to a fee-for-service model.

Severinos team warns that Medicaid has a higher percentage of improper payments than any other federal program, and encourages the program to stop covering nonmedical services like air conditioning and housing. The report says the Centers for Medicare and Medicaid Services should give states more flexibility to strengthen program integrity and to incentivize personal responsibility through work requirements and private insurance.

Severinos team encourages HHS to decommission the CDC and NIH Foundations, nonprofit entities whose boards are populated with pharmaceutical company executives.

Private donations to these foundationsa majority of them from pharmaceutical companiesshouldnot be permitted to influence government decisions about research funding or public health policy, the report urges.

We must shut and lock the revolving door between government and Big Pharma, it adds. Regulators should have a long cooling off period on their contracts (15 years would not be too long) that prevents them from working for companies they have regulated. Similarly, pharmaceutical company executives should be restricted from moving from industry into positions within regulatory agencies.

Severinos team recommends more changes to HHS, including a prioritization of fatherhood in the many social programs HHS controls, and the elimination of the Head Start preschool program and the NIH Office of Equity, Diversity, and Inclusion.

Correction: This article has been corrected to reflect the authorship of the Project 2025 HHS report.

Have an opinion about this article? To sound off, please emailletters@DailySignal.comand well consider publishing your edited remarks in our regular We Hear You feature. Remember to include the url or headline of the article plus your name and town and/or state.

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Biden Weaponized Health Care on Abortion, Transgender, COVID-19 - Daily Signal

Enamine and Endogena Therapeutics a successful, multi-year … – StreetInsider.com

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KYIV, Ukraine--(BUSINESS WIRE)--Enamine Ltd., a provider of drug discovery services empowered with the worlds largest collections of building blocks, fragments, and screening compounds, gave an update of its long-standing research collaboration with Endogena Therapeutics AG, a clinical-stage biotech company focused on the development of endogenous regenerative medicines.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230419005115/en/

Enamine provides Endogena with its integrated capability in medicinal chemistry to support Endogenas small molecule drug discovery programs in the fields of hit finding, hit-to-lead and lead optimization.

The companies have been collaborating under a Full Time Equivalent (FTE) model since 2019. The two discovery partners have been continuing their research collaboration to date, their research relationship not being impacted by the war in Ukraine. This collaboration extension, along with many others and new ones established by Enamine since February 24, 2022, already under the conflict, is a systematic positive trend experienced by the company, that demonstrates the support of its customers and the trust they have in receiving high-quality service backed up by the unparalleled number of diverse building blocks available at Enamine.

Sven Weiler, Vice President of Medicinal Chemistry at Endogena, commented: The interaction with colleagues from Enamine has been a smooth one from the start. In addition to the FTE model, it is great to have access to their huge compound collection and be able to flexibly use Enamines capacity to its full potential. We value the output and responsiveness of the Enamine team, helping us to achieve our demanding milestones. It is stunning to see how well Enamine has been able to keep pace after February 2022.

Michael Bossert, Head of Strategic Alliances at Enamine, added: After 13 months of the war in the country, we are especially pleased to announce our collaboration with Endogena, a long-lasting partner we have been serving during those several years with extensive medicinal chemistry and SAR efforts.

About Enamine Ltd. http://www.enamine.net

Established in Kyiv in 1991, Enamine is a leading global designer and largest producer of building blocks (285,000+), fragments (172,000+) and screening libraries (3M+ compounds). Enamine provides expertise in advanced organic synthesis, library synthesis, and medicinal chemistry. In 2011 Enamine established a pre-clinical service unit including ADME, in-vivo PK studies and High Throughput Screening under the brand name Bienta, allowing the company to tackle since that time fully integrated or -la-carte research programs.

About Endogena AG http://www.endogena.com

Endogena Therapeutics Inc. is a clinical-stage biotech company that discovers and develops first-in-class endogenous regenerative medicines to repair and regenerate tissues and organs. Its approach has the potential to change the way degenerative conditions related to aging and genetic disorders are treated. The concept is based on selective regulation of endogenous adult stem- and progenitor cells for controlled tissue repair by small molecules. Endogenas most advanced programs target degenerative diseases of the eye, including retinitis pigmentosa and geographic atrophy secondary to AMD. Endogena is registered in San Francisco, USA, with a Head office in Zrich, Switzerland, and holds a research facility at JLABS in Toronto, Canada.

View source version on businesswire.com: https://www.businesswire.com/news/home/20230419005115/en/

Enamine Ltd.Michael Bossert[emailprotected]

Endogena Therapeutics[emailprotected]

Source: Enamine Ltd. and Endogena Therapeutics AG

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Enamine and Endogena Therapeutics a successful, multi-year ... - StreetInsider.com

Ask the doctors: Non-hodgkin lymphoma considered very treatable – The Spokesman Review

By Eve Glazier, M.D., and Elizabeth Ko, M.D. Andrews McMeel Syndication

Dear Doctors: My grandfather is 72 years old and has been diagnosed with non-Hodgkin lymphoma. I would like to know more about this type of cancer and what kind of treatment may be involved. Is it unusual for someone his age to get this kind of a diagnosis?

Dear Reader: Lymphoma is a type of cancer that originates in the lymphatic system, most often in the lymph nodes. These are small pea- or bean-sized tissues that, along with a network of vessels, ducts and other structures, make up the lymphatic system. They work together to circulate a specialized fluid known as lymph. You know when you have a scrape and theres a layer of clear, watery fluid oozing from the wound? Thats lymph.

Just as the job of the circulatory system is to transport blood, the lymphatic system carries lymph throughout most of the tissues of the body. It carries away cellular waste and helps maintain optimal fluid balance in the tissues. The lymphatic system is also part of the immune system and plays an important role in fighting infection and disease.

When someone has lymphoma, it means that certain types of white blood cells found in lymph, known as lymphocytes, have begun to grow out of control. Their abnormal behavior leads to the formation of tumors. These not only interfere with the workings of the lymphatic system, but cancer cells from the tumors can spread to other parts of the body.

Lymphoma is divided into two types. One is non-Hodgkin lymphoma, which is your grandfathers diagnosis. This type of cancer is more common in men than in women. Although it can occur at any age, most cases are diagnosed in people 60 and older. A family history of the disease increases someones risk. Certain chemicals and drugs, including insecticides and some types of chemotherapy, are also suspected to play a role.

The other type of lymphoma, known as Hodgkin lymphoma, is not as common. It involves a different subset of lymphocytes and is treated differently from non-Hodgkin lymphoma.

Both types of lymphoma have similar symptoms. These include fatigue; unexplained weight loss; enlarged lymph nodes in the neck, armpits or groin; night sweats; and itching that can become severe.

Non-Hodgkin lymphoma can progress at different rates. A slow-growing cancer that has few symptoms is known as indolent. With this diagnosis, a treatment approach known as watchful waiting is sometimes recommended. Its just as it sounds keeping a close eye on disease progress and not starting treatment unless symptoms begin to change.

When lymphoma spreads quickly and has signs and symptoms that can be severe, it is characterized as aggressive. Aggressive lymphoma requires immediate treatment. The approach depends on the stage at which the cancer is diagnosed, the patients medical history and their general health. Treatment can include chemotherapy, immunotherapy, radiation and targeted drug therapy. In some cases, stem cell or bone marrow transplants may be recommended. These are arduous treatments and can have serious side effects.

Still, although it depends on the type and stage of the cancer, with a five-year survival rate of 74%, non-Hodgkin lymphoma is considered very treatable.

Send your questions to askthedoctors@mednet.ucla.edu.

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Ask the doctors: Non-hodgkin lymphoma considered very treatable - The Spokesman Review

Liskeard teen given second chance at life thanks to complete stranger from Germany who donated stem cells – Cornwall Live

A boxer from Cornwall with a rare condition has been given a second chance at life thanks to a complete stranger who donated stem cells. Charlie Dugdale, aged 17, had just qualified to become a chef in Winchester and was waiting to go to Plymouth to start his submarine training in the Royal Navy when he was diagnosed with aplastic anaemia - a type of blood disorder where your bone marrow doesnt make enough blood cells - at the end of last year.

Charlie underwent multiple blood transfusions as well as a platelet transfusion but was informed by doctors that a stem cell transplant was needed to give him a second chance at life. So, his family teamed up with blood cancer charity, Anthony Nolan, to help find Charlie a donor and to encourage people from all backgrounds to sign up to become potential donors.

After a number of stem cell donation rallies were held across Liskeard, Charlie was able to find a match on the Anthony Nolan stem cell register - which came from a donor in Germany - and successfully received a stem cell transplant last month. Following an initial recovery period in hospital, Charlie is now back home and continues to recover well from his transplant.

Read more: Redruth mum who almost died after giving birth wants to raise awareness of pre-eclampsia

His father, Thomas Dugdale, has described the success of the transplant as being 'a miracle' and said his family couldn't be more grateful for the support they received from the community and those who donated stem cells to help save Charlie's life. "It's amazing and it's a miracle we found a perfect match for him," Thomas told CornwallLive.

"The transplant went really well and aside from an infection he got just after, he is doing well now. He's also gained 10 kilograms since and aside from the odd days, he's almost back to himself, which means the world to us."

Despite the fact that the stem cells came from a donor in Germany, Thomas said his family is still grateful for the donor days that were held and wanted to thank everyone who donated. "The stem cell donation actually came from Germany and it was a perfect 12/12 match for Charlie," he said.

"But I don't want to take away from the donor days we held because those donations could still help others in need. It was still lovely to know that all these people came forward to help Charlie and we can't thank everyone enough."

He said he also hopes to meet the stranger who saved Charlie's life in the future and thank them in person. "We have to wait about two years before we're able to have the opportunity to meet the person who the donated stem cells that helped give Charlie a second chance at life," he said. "I'm really looking forward to it, I'll never be able to thank them enough."

Now Thomas, who is an Officer and Engineer in the Royal Navy, is set to run the London Marathon this weekend to help raise money for Anthony Nolan. The 39-year-old previously ran the New York Marathon in 2018, but was keen to run the London Marathon this year to raise money and bring awareness to the charity that has had a significant impact on Charlies life.

"Whilst I had heard of Anthony Nolan before, I wasnt really aware of exactly what they did until what happened to our family," he said. "Its incredible work, and Im really glad Ive got the opportunity to share how important they are and the work they do. It's also really important to encourage more people to come forward to donate stem cells, so that it can help save other people's lives."

Thomas has had to overcome a few challenges during training, including multiple work trips abroad and battling a chest infection. However, throughout these difficulties, he said he has taken inspiration from Charlies attitude towards overcoming barriers, which has helped him push forward with his training.

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"There were days Charlie didnt want to do his chemotherapy or have his treatment, but he never moaned once and was incredibly strong throughout his treatment," he said. "On the days I didnt want to go for a run, I take strength from what Charlie has overcome and realise that if he can go through what he went through, then I can make it through a 26-mile run. I want to show my gratitude towards his strength."

So far, Thomas has smashed his fundraising target and has already raised 6,927 of the 5,000 goal. However, he hopes to continue raising more funds for the vital charity in the days leading up to and after the marathon and has set himself a new fundraising target of 7,000.

You can view his fundraising page, here.

Anthony Nolan are calling for more people between the ages of 16 and 30 to join the register, specifically young men as research shows that they have the most success donating. Currently just 18% of the UK Anthony Nolan stem cell register is made up of young men, but they account for 55% of people called upon to donate, and potentially save the lives of people like Charlie.

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Liskeard teen given second chance at life thanks to complete stranger from Germany who donated stem cells - Cornwall Live

CDC allows second covid booster: Who should get it and when – The Washington Post

Federal health officials this week updated their recommendations for coronavirus vaccinations to allow people who are at least 65 years old or immunocompromised to receive a second updated booster shot to strengthen protection for the most vulnerable Americans, even as the virus recedes.

The Food and Drug Administration authorized the additional shot for those high-risk groups, and Rochelle Walensky, director of the Centers for Disease Control and Prevention, signed off Wednesday after the agencys vaccine advisers met to discuss its benefits. People who are eligible for additional boosters should be able to get them later this week.

Federal health officials also simplified coronavirus vaccinations for everyone going forward. Anyone getting a Pfizer-BioNTech or Moderna shot whether a booster or first-ever vaccination will now get an updated vaccine, known as a bivalent shot, not the original vaccines, called monovalents. Health officials say the bivalent shots more closely match the circulating virus. For unvaccinated adults, that means one shot instead of several doses of the original vaccine.

Many people are likely to have questions about who should get a second booster, the best timing and what the recommendations mean for younger age groups. The changes for young children are more complicated. The recommendations will vary by age, vaccine and which shots they received previously. The CDC plans to post a detailed chart with recommendations for children under 6.

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CDC allows second covid booster: Who should get it and when - The Washington Post

Immunotherapy Regenerative Medicine: Advanced Care With … – Wealth Of Geeks

Medical science has witnessed remarkable advancements in recent years, moving beyond traditional medicine toward the field of regenerative and proteomics medicine. While conventional methods focus on treating symptoms and managing diseases, regenerative medicine promotes the body's natural healing mechanisms to repair damaged tissues and organs.

This approach has become increasingly popular due to its potential to offer long-term benefits and reduce the need for invasive procedures or medications.

Immunotherapy Regenerative Medicine is a clinic that champions the power of natural healing to treat chronic degenerative diseases, autoimmune disorders, or neurological problems. Harnessing the power of high-level stem cell therapy, they enable the body's own regeneration and healing process.

As a leader in stem cell research based in Puerto Vallarta, Mexico, Immunotherapy Regenerative Medicine holds over 20 years of experience under the leadership of regenerative medicine expert Dr. Ernesto Romero.

Dr. Romero's visionary leadership at the forefront of regenerative medicine began over 17 years ago with the belief that Stromal Cell Precursors, a type of stem cell, were the next step in advancing people's health. Since then, he has advocated for this innovative approach as a potential solution for many suffering patients to improve their quality of life, far surpassing the results of traditional medicinal methods.

Regenerative medicine uses various techniques such as Mesenchymal stem cell therapy, gene therapy, and immunotherapy, to stimulate tissue regeneration and promote healing. At its core, regenerative medicine relies on preparing a correct environment and then using stem cells, which can segment into different types of cells in the body depending on the signals they receive.

Mesenchymal stem cells (MSCs) are one of the most researched cells for regenerative therapies. MSCs are adult stem cells with self-renewal, immunomodulatory, anti-inflammatory, signaling, and differentiation properties. Depending on the environment created for them, they can be used to regenerate or replace damaged tissues, allowing the body to heal itself in a way that was previously impossible.

Dr. Romero explains, By using the body's own healing mechanisms, regenerative medicine offers a safe, effective, and minimally invasive way to treat these conditions and improve patient outcomes.

Immunotherapy Regenerative Medicine is at the forefront of the regenerative field, offering patients comprehensive and innovative medical care through the most advanced regenerative and proteomics medicine techniques.

One of the techniques employed by Immunotherapy Regenerative Medicine is stem cell therapy. Their treatment methods use high-quality MSCs spanning a vitality of 95% to 98% to repair and regenerate damaged tissues, with the potential to treat a wide range of conditions, including chronic degenerative diseases, autoimmune diseases, aging conditions, and neurological and musculoskeletal disorders, such as stroke and heart problem.

Due to its high compatibility, mesenchymal stem cells develop into many cell types to help regenerate tissue and regulate the immune system.

At Immunotherapy Regenerative Medicine, patients can be assured that their regenerative medicine treatments are carefully planned and monitored for the best possible outcomes. Led by Dr. Romero and a team of professionals composed of doctors, biologists, biophysicists, biochemists, and nutritionists, the clinic recognizes that regenerative medicine is a significant investment for every that might be looking to improve their quality of life and used traditional medicine but failed to help them completely recuperate. So to ensure undeniable success results, the team takes a personalized approach to every treatment.

Rather than simply administering stem cells and hoping for the best, they take the time to get to know each patient's unique needs and body. By doing so, they can adequately prepare patients for therapy and recommend ways to improve their overall health and healing. With every treatment closely monitored and planned, patients can have the utmost confidence in its quality and compatibility. Patients can trust that their investment in regenerative medicine will result in long-lasting benefits for their health and well-being.

Dr. Romero believes that by combining these advanced techniques and personalized approaches, Immunotherapy Regenerative Medicine is pushing the boundaries of medical care, offering patients a new paradigm in healing and recovery.

Immunotherapy Regenerative Medicine takes pride as a pioneer in medical innovation and research. They are the first to adopt immunotherapy treatments and stem cell therapy in Mexico. By catering to medical tourism, they continually pursue excellence through their commitment to research and development. The team is constantly unlocking new ways and methods of treatment. They offer hope to patients and their families, allowing them to look forward to improved health and better quality of life now and in the years to come.

This article was produced and syndicated byWealth of Geeks.

Sam Allcock is thefounder of PR Fire. His team help small to medium-sized businesses achieve coverage in publications like Yahoo Finance, Daily Mail, Metro, USA Today, MSN News, The Huffington Post, and The Telegraph through smart press release distribution.

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Scots Football hosting "Be the Match" registry event – WQKT

The College of Wooster is among the latest college football teams to join forces with Be The Match and get in the game with a blood stem cell registry drive. Woosters drive will take place on Friday, April 28 from 10 a.m. 3 p.m. inside the Lowry Student Center at the student tabling tables.

Hundreds of college athletic teams have registered thousands of their team members, peers, and local community members for the Be The Match Registry. Wooster football players will run tables to assist students, faculty, staff, and local community members with their Be The Match process, which includes a registration, filling out a health history form, and providing a swab inside your cheek. The registry drive is open to people ages 18 to 40 years old, and the event is open to the local community.

More young people of diverse racial and ethnic heritage are needed to help patients searching for a match. People between the ages of 18 and 35 are most urgently needed since they are requested by transplant doctors most often, and research shows that these donors provide the greatest chance for transplant success.

Every year, 12,000 patients are diagnosed with life-threatening blood cancers or other diseases like sickle cell, for which a blood stem cell transplant from an unrelated donor may be their best or only hope for a cure. Be The Match connects patients with a matching donor for a life-saving blood stem cell transplant. A blood stem cell transplant can cure or treat more than 75 difference diseases, including leukemia and lymphoma, aplastic anemia, and sickle cell and immune-deficiency disorders. Be The Match has facilitated more than 120,000 transplants since 1987 and continues to impact more lives every year. Be The Match is a global leader in bone marrow transplantation and conducts research to improve transplant outcomes, provides support and resources for patients, and partners with a global network.

Football teams, especially small college teams within Ohio, can help effectively communicate signing up for Be The Match, added junior defensive back Andrew Armile, who is helping spearhead Woosters registry event. Through community involvement and with the large number of football programs in the country, we can help by spreading the important message of registering for blood and marrow donations and hopefully save lives.

Those unable to make Woosters football teams registry drive can join the Be The Match donor registry online, order a free cheek swab kit from Be The Match, and return it to the organization.

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Scientists achieve promising results towards restoring vision in … – Ophthalmology Times

This finding marks a first step towards potentially restoring vision in eye diseases characterized by photoreceptor loss. (Image credit: AdobeStock/Victoria Key)

A preclinical study using stem cells to produce progenitor photoreceptor cellslight-detecting cells found in the eyeand then transplanting these into experimental models of damaged retinas has resulted in significant vision recovery.

According to a Duke-NUS Medical School news release, this finding, by scientists at Duke-NUS Medical School, the Singapore Eye Research Institute and the Karolinska Institute in Sweden, marks a first step towards potentially restoring vision in eye diseases characterized by photoreceptor loss.

Our laboratory has developed a novel method that enables the production of photoreceptor progenitor cells resembling those in human embryos, Tay Hwee Goon, PhD, first author of the study from Duke-NUS Centre for Vision Research, said in the news release. Transplantation of these cells into experimental models has yielded partial restoration of the retinal function.

The degeneration of photoreceptors in the eye is a significant cause of declining vision that can eventually lead to blindness and for which there is currently no effective treatment. Photoreceptor degeneration occurs in a variety of inherited retinal diseases, such as retinitis pigmentosaa rare eye disease that breaks down cells in the retina over time and eventually causes vision lossand age-related macular degeneration, a leading cause of vision impairment worldwide.1

Asst Prof Tay and her team developed a procedure to grow human embryonic stem cells in the presence of purified laminin proteins that are involved in normal development of human retinas. In the presence of the laminins, stem cells could be directed to differentiate into photoreceptor progenitor cells responsible for converting light into signals that are sent to the brain.

When these cells were transplanted into damaged retinas, the preclinical models showed significant recovery of vision. A diagnostic test called electroretinogram also identified significant recovery in the retinas via electrical activity in the retina in response to a light stimulus. The transplanted cells established connections with surrounding retinal cells and nerves in the inner retina. They also survived and functioned for many weeks after transplantation.

Moving forward, the team said in the news release it hopes to refine their method to make it simpler and achieve more consistent results than earlier attempts to explore stem cell therapy for photoreceptor cell replacement.

It is exciting to find these results, which suggest a promising route towards using stem cells to treat those forms of visual deterioration and blindness caused by the loss of photoreceptors, Helder Andre, PhDm head of Molecular and Cellular Research from Karolinska Institutes Department of Clinical Neuroscience and a senior author of the study, said in the news release.

Enrico Petretto, PhD, director of the Centre for Computational Biology at Duke-NUS and the study's bioinformatics analysis lead, discussed the research.

Our method may also be useful for understanding the molecular and cellular pathways that drive the progression of macular degeneration, perhaps leading to the development of other therapeutic approaches, he said in the news release.

According to the release, the next challenge for the researchers is to explore the efficacy of their method in models of photoreceptor degeneration that more closely match the human condition.

If we get promising results in our future studies, we hope to move to clinical trials in patients, Karl Tryggvason, MD, PhD, from Duke-NUS Cardiovascular and Metabolic Disorders Program, and the corresponding author of the study, said in the release. That would be an important step towards for being able to reverse damage of the retina and restore vision.

The protocol underlying the procedure developed by Tay has since been licensed to Swedish biotech start-up Alder Therapeutics.

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Unsure About Why Your Hair Is Going Grey? Scientists Might Have Found The Answer | HealthBeat – Times Now

Hair usually starts to slowly lose colour from 35 years of age while this can occur earlier as well. Colour produced at the hair follicle, pores around the root of hair, does not change the colour once hair starts to grow. With age, these follicles fail to produce enough pigment, as a result, once hair dies and regrows, it does not change the colour.

Updated Apr 20, 2023 | 03:45 PM IST

Published in the Nature journal, the study looked at how stem cells can affect follicles ability to produce colour.

Photo : iStock

Why does hair start to go grey?

Hair usually starts to slowly lose colour from 35 years of age while this can occur earlier as well. Colour produced at the hair follicle, pores around the root of hair, does not change the colour once hair starts to grow. With age, these follicles fail to produce enough pigment, as a result, once hair dies and regrows, it does not change the colour.

During normal growth of hair, cells continuously move back and forth during transition between compartments of developing hair follicles. But as hair ages and grows back, the number of melanocyte stem cells gets stuck in the stem cell compartment resulting in a bulge and preventing colouring. The loss of such function in the stem cells could take blame for loss of hair colour and greying. Findings suggest that such stem cell motility and reversible differentiation could be key to keeping hair coloured and healthy.

Disclaimer: Tips and suggestions mentioned in the article are for general information purposes only and should not be construed as professional medical advice. Always consult your doctor or a dietician before starting any fitness programme or making any changes to your diet.

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Unsure About Why Your Hair Is Going Grey? Scientists Might Have Found The Answer | HealthBeat - Times Now