Cracking the fresh cell code

Experience and expertise run in the genes of this doctor, a third-generation fresh cell therapy practitioner

It was a pleaseant, winter morning in Edenkoben, Germany and a group of 15 people from various countries such as Indonesia, the Philippines, Italy, and Germany congregated for breakfast in a coffee shop in this quaint city. Most of these people just flew in from their respective countries, or drove in from different European cities.

But they were not there for an international conference. They were all there for their shots of fresh cell from Dr. Robert Janson-Mueller.

For the past couple of years, through his solo practice, Dr. Robert Mueller has been sharing the benefits of fresh cell therapy with people who need to seek alternative means to remedy various diseases or chronic conditions of their body, or anti-aging solutions.

Although Filipinos has heard of stem cell therapy only in recent years, thanks to celebrities and politicians who have undergone the treatment and do swear by its efficacy, fresh cell therapy has been around since the 1930s.

The Swiss doctor Prof. Paul Niehans first injected cells originating from animal organs intramuscular into patients in 1931 and is thus considered the founder of live cell therapy. Dr. Robert Muellers grandfather, Dr. Philipp Janson, was one of the first doctors to introduce this method in Germany in 1949. His father, Dr. Wolfgang Janson-Meller, also extensively practiced for 35 years.

Since the 90s, I have been able to participate in the wealth of experience that my father, who is always available for help and advice, has gladly passed on to me. I have been using this method of treatment in my own practice since 2003, says Dr. Mueller.

However, the 47-year old doctor differentiates his practice from others (there are only five known doctors who do fresh cell therapy in Germany) because his clinic tailor-fits the fresh cell injections according to the specific needs of the individuals body. A patient thus gets from about eight to 30 injections, depending on the needs.

In this interview with Dr. Mueller, the German expert sheds more light on this therapy that is attracting more and more Filipinos as an alternative treatment. He also explains why fresh cell therapy is not a cure-all or a miracle therapy, why cells from the sheep embryo is being used, why the treatment is becoming popular in Asia, and why it is not possible, up to now, that these therapies can be done in the Philippines.

For more information on fresh cell therapy, visit the website http://www.janson-mueller.de or call Joey Santos at 0917898-6564 or 633-8653.

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Cracking the fresh cell code

Stem Cell Doctor, Autologous Stem Cell Therapy, Stem Cell …

STEVEN M. GITT, M.D., F.A.C.S.

Steven M. Gitt, M.D., F.A.C.S. specializes in plastic surgery, offering the latest and most innovative techniques in: facial rejuvenation, breast augmentation, laser surgery, liposuction and body contouring and all facets of cosmetic surgery. His patients describe him as caring, compassionate, and understanding and as an excellent listener and communicator.

As the founder and medical director of North Valley Plastic Surgery, established in 1993, Dr. Gitt graduated college with distinction from UCLA in 1982 and from medical school with distinction from Wayne State University in 1986. Dr. Gitt was elected to membership in the prestigious Alpha Omega Alpha (AOA) national medical honor society in 1985.

Following completion of training in General Surgery at Good Samaritan Hospital in Phoenix, and Plastic Surgery training at the renowned University of Michigan medical center, Dr. Gitt obtained certifications from the American Board of Surgery and the American Board of Plastic Surgery. Dr. Gitt also holds the prestigious Certificate of Advanced Education in Cosmetic Surgery. He was the founder and original medical director of the Comprehensive Wound Healing Center at Paradise Valley Hospital in Phoenix, Arizona. Dr. Gitt is a board certified (and re-certified)Plastic Surgeon and General Surgeon. He is a member of the American Society of Plastic Surgeons and a fellow of the American College of Surgeons.

While studying at the University of Washington in Seattle, Ryan Tsujimura graduated magna cum laude with a B.S. in Biology and went on to finish at the top of his class in medical school.

Dr. Tsujimura initiated his postgraduate training at the Oregon Health Sciences University (University of Oregon) in Portland, Oregon where he did his internship in General Surgery. He then moved to Phoenix where he finished his residency in General Surgery. During this time he became Chief Resident of the Burn Unit and then Chief Resident of Surgery in his last year of training.

He was given various awards during his training, but the most meaningful was the distinction made by the Chairman of Surgery/Program Director and Mentor: Ive been training surgeons for over a decade, nd youre the best surgeon Ive been fortunate enough to train.

After becoming certified by the American Board of Surgery, Dr. Tsujimura took an Attending Trauma Surgeon at Maricopa County Hospital. This gave him the opportunity to give back to the community and to teach future surgeons. During this time, he also entered practice and joined the staff of the Scottsdale Healthcare System performing general and vascular operations.

In the continued pursuit to perfect his skills, Dr. Tsujimura entered a fully accredited Plastic, Reconstructive and Hand Surgery program at the University of Tennessee. Before becoming Administrative Chief Resident, he published and lectured on various topics in Aesthetic and Reconstructive Surgery.

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Stem Cell Doctor, Autologous Stem Cell Therapy, Stem Cell ...

Ears and noses to be grown in lab from stem cells for human transplants thanks to revolutionary technique

Scientists have managed to use body fat and turned it into cartilage It is now hoped technique could help patients born with microtia At the moment, doctors take cartilage from other parts of the body

By Daily Mail Reporter

PUBLISHED: 06:43 EST, 2 March 2014 | UPDATED: 06:46 EST, 2 March 2014

British scientists are aiming to grow ears and noses in a laboratory to transplant then into humans.

Scientists from Great Ormond Street Hospital and University College London have managed to use abdominal body fat and turn it into cartilage.

It is now hoped that the technique could help patients who have been born with microtia, which means the ear fails to develop properly, or who have been in an accident.

Scientists from Great Ormond Street Hospital are aiming to grow ears and noses in a laboratory to transplant then into humans

At the moment, surgeons take cartilage from other parts of the body to treat children with facial defects.

The painful procedure sees them shape the nose or ear, and implant it into the child, The Telegraph reports.

The new technique would mean that doctors 'grow' the organ separately using a tiny sample of fat from the child.

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Ears and noses to be grown in lab from stem cells for human transplants thanks to revolutionary technique

Stem Cell Therapy 'Reverses Ageing Process' in Millionaire Peter Nygard

Peter Nygard hopes to build stem cell research clinic in the Bahamas(Screengrab)

A millionaire fashion designer living in the Bahamas has claimed he is getting younger because of stem cell treatment.

Peter Nygard, a Canadian citizen born in Finland, claimed scientists were hoping to use him as an example of how stem cells could reverse the ageing process.

Nygard was said to be hoping to open a stem cell clinic in the Bahamas after prime minister Perry Christie passed legislation allowing stem cell research and therapy to take place.

Nygard told the Bahamas Tribune: "Stem cells are being used for anti-ageing and the University of Miami is doing a study about that to prove that it is true. They are looking at me, and my markers have shown exactly that I have been actually reversing my ageing and getting younger.

"I am taking perhaps more stem cell treatment than anybody else in the world. I have been doing it for four years now, so I am sort of a testimonial that this stem cell really works."

The founder and chairman of Nygard International is assessing possible locations in the Bahamas where he can build his stem cell clinic, estimated to cost around $50m (29m).

Nygard said his interest in stem cell research arose after his mother became seriously ill.

He told Freeport News:"I started stem cells when I wanted to find a cure for my mother who I loved very much and western medicine was not able to cure her.

"If I had discovered stem cells a year before, I think that she would still be here with me."

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Stem Cell Therapy 'Reverses Ageing Process' in Millionaire Peter Nygard

Stem Cell Research – Journal – Elsevier

Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancer stem cells, developmental studies, stem cell genomes, and translational research. Stem Cell Research publishes 6 issues a year.

The journal publishes

Original articles Short reports Review articles Communications Methods and reagents articles

Stem Cell Research collaborates with journals published by Cell Press. Our editorial board is happy to consider submissions reviewed at Cell Stem Cell or other Cell Press journals which are considered to be scientifically sound, but not impactful enough for the readership of Cell Press journals. Authors should include their Cell Press reviews (which will be confirmed by Cell Press) for fast-track consideration. In SCR's fast track system, the SCR office will inform you within 3-5 days if the manuscript warrants further consideration for publication. The editors reserve the right to (a) reject the manuscript, (b) accept the manuscript with no further review, (c) send the manuscript out for further review, (d) require revisions based on the Cell Press or further reviews.

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Stem Cell Research - Journal - Elsevier

Pros And Cons Of Stem Cell Research – Popular Issues …

You are here: Popular Issues >> Pros And Cons Of Stem Cell Research

Pros and Cons of Stem Cell Research - What are Stem Cells? There has been much controversy in the press recently about the pros and cons of stem cell research. What is the controversy all about? "Stem" cells can be contrasted with "differentiated" cells. They offer much hope for medical advancement because of their ability to grow into almost any kind of cell. For instance, neural cells in the brain and spinal cord that have been damaged can be replaced by stem cells. In the treatment of cancer, cells destroyed by radiation or chemotherapy can be replaced with new healthy stem cells that adapt to the affected area, whether it be part of the brain, heart, liver, lungs, or wherever. Dead cells of almost any kind, no matter the type of injury or disease, can be replaced with new healthy cells thanks to the amazing flexibility of stem cells. As a result, billions of dollars are being poured into this new field.

Pros and Cons of Stem Cell Research - Where Do They Come From? To understand the pros and cons of stem cell research, one must first understand where stem cells come from. There are three main sources for obtaining stem cells - adult cells, cord cells, and embryonic cells. Adult stem cells can be extracted either from bone marrow or from the peripheral system. Bone marrow is a rich source of stem cells. However, some painful destruction of the bone marrow results from this procedure. Peripheral stem cells can be extracted without damage to bones, but the process takes more time. And with health issues, time is often of the essence. Although difficult to extract, since they are taken from the patient's own body, adult stem cells are superior to both umbilical cord and embryonic stem cells. They are plentiful. There is always an exact DNA match so the body's immune system never rejects them. And as we might expect, results have been both profound and promising.

Stem cells taken from the umbilical cord are a second very rich source of stem cells. Umbilical cells can also offer a perfect match where a family has planned ahead. Cord cells are extracted during pregnancy and stored in cryogenic cell banks as a type of insurance policy for future use on behalf of the newborn. Cord cells can also be used by the mother, the father or others. The more distant the relationship, the more likely it is that the cells will be rejected by the immune system's antibodies. However, there are a number of common cell types just as there are common blood types so matching is always possible especially where there are numerous donors. The donation and storage process is similar to blood banking. Donation of umbilical cells is highly encouraged. Compared to adult cells and embryonic cells, the umbilical cord is by far the richest source of stem cells, and cells can be stored up in advance so they are available when needed. Further, even where there is not an exact DNA match between donor and recipient, scientists have developed methods to increase transferability and reduce risk.

Pros and Cons of Stem Cell Research - Embryonic Cells The pros and cons of stem cell research come to the surface when we examine the third source of stem cells - embryonic cells. Embryonic stem cells are extracted directly from an embryo before the embryo's cells begin to differentiate. At this stage the embryo is referred to as a "blastocyst." There are about 100 cells in a blastocyst, a very large percentage of which are stem cells, which can be kept alive indefinitely, grown in cultures, where the stem cells continue to double in number every 2-3 days. A replicating set of stem cells from a single blastocyst is called a "stem cell line" because the genetic material all comes from the same fertilized human egg that started it. President Bush authorized federal funding for research on the 15 stem cell lines available in August 2001. Other stem cell lines are also available for research but without the coveted assistance of federal funding.

So what is the controversy all about? Those who value human life from the point of conception, oppose embryonic stem cell research because the extraction of stem cells from this type of an embryo requires its destruction. In other words, it requires that a human life be killed. Some believe this to be the same as murder. Against this, embryonic research advocates argue that the tiny blastocyst has no human features. Further, new stem cell lines already exist due to the common practice of in vitro fertilization. Research advocates conclude that many fertilized human cells have already been banked, but are not being made available for research. Advocates of embryonic stem cell research claim new human lives will not be created for the sole purpose of experimentation.

Others argue against such research on medical grounds. Mice treated for Parkinson's with embryonic stem cells have died from brain tumors in as much as 20% of cases.1 Embryonic stem cells stored over time have been shown to create the type of chromosomal anomalies that create cancer cells.2 Looking at it from a more pragmatic standpoint, funds devoted to embryonic stem cell research are funds being taken away from the other two more promising and less controversial types of stem cell research mentioned above.

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Footnotes 1 The Real Promise of Stem Cell Research Dr. David Prentice, HealthNewsDigest.com 2 Derivation of Human Stem-Cell Lines from Human Blastocysts, C. A. Cowan and others. March 25, 2004, New England Journal of Medicine, p.1355 with secondary reference to footnotes 13-17 p.1356.

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Stem Cells – Research | ucsf.edu

Since the success in 1998 by the University of Wisconsins James Thomson in deriving human embryonic stem cells from embryos, the stem cell research field has exploded.

The discovery by Japans Shinya Yamanaka, MD, PhD,in 2006, of how to transform ordinary adult skin cells into cells that, like embryonic stem cells, are capable of developing into any cell in the human body, has revolutionized stem cell research.

At top, Robert Blelloch, MD, PhD, performs stem cell research. Above,Shinya Yamanaka, MD, PhD, a scientist at the UCSF-affiliated Gladstone Institutes, UCSF and Kyoto University, was recognized for a revolutionary achievement in the field of stem cell science with a Nobel Prize in Medicine in 2012.

In between and since, there has been major progress in scientists understanding of stem cells. Today, fueled in part by the robust research enterprise at UCSF, the field is burgeoning.Yamanaka, a senior investigator at the UCSF-affiliated Gladstone Institutes and a professor of anatomy at UCSF, shared the Nobel Prize in Physiology and Medicine with John B. Gurdon of the Gurdon Institute in Cambridge, England, in 2012.

In about 125 labs of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF one of the largest such programs in the country scientists are carrying out the basic research needed to understand how stem cells could be manipulated to treat diseases, to translate these findings into clinical research and to develop novel therapies.

In studies conducted in the culture dish and in animals, scientists are learning how to prompt stem cells to develop into specialized cells of tissues such as the heart, pancreas and brain. The ultimate goal is to transplant these cells into patients to regenerate damaged tissues.

The scientists also are exploring the use of stem cells as vehicles for delivering drugs into diseased tissues, and are using specialized cells produced by stem cells, such as liver and heart muscle cells, to test the effectiveness of experimental drugs in the culture dish. In addition, they are studying the role of stem cells in generating many forms of cancer, an important first step for targeting the cells for therapies.

The center is structured along seven research pipelines aimed at driving discoveries from the lab bench to clinical care. Each pipeline focuses on a different organ system: the blood, pancreas and liver, heart, reproductive organs, nervous system, musculoskeletal tissues and skin. And each pipeline is overseen by two leaders of international standing one representing the basic sciences and one representing clinical research. The approach has proven successful in the private sector for driving the development of new therapies.

Among the basic science studies being conducted by UCSF investigators are:

Exploring a novel stem cell strategy for treating brain diseases Five UCSF labs are pioneering a novel approach to treating brain diseases and injuries, using a particular type of embryonic stem cell to manipulate the brains neural circuitry. They recently reported the first use of the cells, which mature into neurons, in creating a new period of plasticity, or capacity to change, in the brains of rodents.

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Stem Cells - Research | ucsf.edu

Stem cell controversy – Wikipedia, the free encyclopedia

The stem cell controversy is the bioethical debate primarily concerning the creation, treatment, and destruction of human embryos incident to research involving embryonic stem cells. Not all stem cell research involves the creation, use, or destruction of human embryos. For example, adult stem cells, amniotic stem cells and induced pluripotent stem cells do not involve human embryos.

Stem cells have the ability to differentiate into almost any specialized cells, helping heal physical trauma, degenerative conditions, and genetic diseases (in combination with gene therapy). Further treatments using stem cells could potentially be developed thanks to their ability to repair extensive tissue damage.[1]

Great levels of success and potential have been shown from research using adult stem cells. In early 2009, the FDA approved the first human clinical trials using embryonic stem cells. Embryonic stem cells are pluripotent, and thus can become any other cell type excluding the placenta. Adult stem cells, however, are generally limited to differentiating into different cell types of their tissue of origin. However, some evidence suggests that adult stem cell plasticity may exist, increasing the number of cell types a given adult stem cell can become. In addition, embryonic stem cells are considered more useful for nervous system therapies, because researchers have struggled to identify and isolate neural progenitors from adult tissues. Embryonic stem cells, however, might be rejected by the immune system - a problem that wouldn't occur if the patient received his or her own stem cells.

Some stem cell researchers are working to develop techniques of isolating stem cells that are as potent as embryonic stem cells, but do not require a human embryo.

Some believe that human skin cells can be coaxed to "de-differentiate" and revert to an embryonic state. Researchers at Harvard University, led by Kevin Eggan, have attempted to transfer the nucleus of a somatic cell into an existing embryonic stem cell, thus creating a new stem cell line.[2] Another study published in August 2006 also indicates that differentiated cells can be reprogrammed to an embryonic-like state by introducing four specific factors, resulting in induced pluripotent stem cells.[3] Human skins cells reverting to their embryonic state have been accomplished at the Oregon Health & Science University and the Oregon National Primate Research Center, making this no longer a matter of belief.[4]

Researchers at Advanced Cell Technology, led by Robert Lanza, reported the successful derivation of a stem cell line using a process similar to preimplantation genetic diagnosis, in which a single blastomere is extracted from a blastocyst.[5] At the 2007 meeting of the International Society for Stem Cell Research (ISSCR),[6] Lanza announced that his team had succeeded in producing three new stem cell lines without destroying the parent embryos. "These are the first human embryonic cell lines in existence that didn't result from the destruction of an embryo." Lanza is currently in discussions with the National Institutes of Health (NIH) to determine whether the new technique sidesteps U.S. restrictions on federal funding for ES cell research.[7]

Anthony Atala of Wake Forest University says that the fluid surrounding the fetus has been found to contain stem cells that, when utilized correctly, "can be differentiated towards cell types such as fat, bone, muscle, blood vessel, nerve and liver cells". The extraction of this fluid is not thought to harm the fetus in any way. He hopes "that these cells will provide a valuable resource for tissue repair and for engineered organs as well".[8]

While stem cell research has, for years, been stymied by concerns of ethics and morals, in recent years there have been advances in obtaining and using stem cells extracted from adult subjects. By using stem cells taken from an adult, scientists have been able to treat some of the worst diseases that continue to plague our species, including various forms of cancer as well as muscular and neurological degenerative diseases. Taking these stem cells from adults does not permanently harm the patient and has none of the ethical or moral pitfalls that embryonic stem cell research has been associated with. While this new form of stem cell research is gaining in popularity, it still has a stigma attached to it solely by being stem cell research. If the public can be educated about this, a new form of medicine may be fast approaching from the horizon.

The status of the human embryo and human embryonic stem cell research is a controversial issue as, with the present state of technology, the creation of a human embryonic stem cell line requires the destruction of a human embryo. Stem cell debates have motivated and reinvigorated the pro-life movement, whose members are concerned with the rights and status of the embryo as an early-aged human life. They believe that embryonic stem cell research instrumentalizes and violates the sanctity of life, and some also view it as tantamount to murder.[9] The fundamental assertion of those who oppose embryonic stem cell research is the belief that human life is inviolable, combined with the belief that human life begins when a sperm cell fertilizes an egg cell to form a single cell.

A portion of stem cell researchers use embryos that were created but not used in in vitro fertility treatments to derive new stem cell lines. Most of these embryos are to be destroyed, or stored for long periods of time, long past their viable storage life. In the United States alone, there have been estimates of at least 400,000 such embryos.[10] See also Embryo donation.

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Stem cell controversy - Wikipedia, the free encyclopedia

Billionaire says he's reversed the aging process

A Finnish-Canadian billionaire says scientists have found a way to make him younger. Fashion designer Peter Nygard claims he is getting more stem cell treatment than anyone else is currently receiving, and scientists have found "my markers have shown exactly that I have been actually reversing my aging and getting younger," the BBC reports.

The 70-year-old says he has been undergoing stem cell treatment for four years, and that the University of Miami is currently studying him. Nygard lives in the Bahamas, where he is an advocate for stem cell research and wants to open a $50 million stem cell clinic.

He says his interest in the subject is about more than just a desire to be younger. "I started stem cells when I wanted to find a cure for my mother who I loved very much and Western medicine was not able to cure her, he tells the Freeport News. "If I had discovered stem cells a year before, I think that she would still be here with me." The Winnipeg Free Press notes that Nygard has released a 10-minute YouTube video ("Bahamas Stem Cell Laws: The Peter Nygard Breakthrough") that shows him "dancing with young women in a nightclub" (with a Will.i.am and Britney Spears song playing in the background), "leaning out of a sailboat, playing volleyball," and living what the narrator describes as "a life that most could only dream of." (Harvard scientists recently said they were able to reverse part of the aging process ... in mice.)

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Billionaire says he's reversed the aging process

Chernoff Cosmetic Surgery Pleased to Offer Innovative Phytoceutical Apple Stem Cell Facial

Indianapolis, IN (PRWEB) February 28, 2014

Chernoff Cosmetic Surgeons is excited to bring Phytoceutical science to Indianapolis, offering patients an innovative new treatment in the form of the Apple Stem Cell Facial.

A phytoceutical is a plant-derived compound with skin and health benefits. The benefits of phytoceuticals and apple stem cells have been witnessed in Europe and some Asian Countries, but have not gained much exposure in the U.S. until now. Dr. Gregory Chernoff of Chernoff Cosmetic Surgeons is excited to bring this effective and innovative treatment to Indianapolis.

Apple Stem Cells contain similar Epigenetic Factors as human stem cells. Together, these growth factors and the complex of science-based plant nutrients provide optimal improvement in skin health, says Dr. Chernoff.

The innovative facial uses special Malus apple stem cells combined with a phytoceutical complex, both of which are rich in growth factors. This powerful combination is used to enhance collagen production and stimulate fibroblast regeneration. Additional key ingredients in this facial that make it unique are polysaccharides that improve connective tissue and stimulate micro blood circulation, and pectin extract which acts as a fibroblast nutrient to improve skin.

This benefits of this new treatment can be maximized using enhanced delivery with micro needling. Micro needling is a form of non-ablative collagen induction therapy. This technique delivers active apple stem cells, growth factors, vitamins & nutrients deep into the dermis, providing intensive fibroblast and cell regeneration. Hyaluronic acid and tri-lipids seal in the active growth factors.

Apple stem cells are not something new to Dr. Chernoffs patients. His professional line of skincare offers an Apple Stem Cell Serum that his patients have been using for years. The Apple Stem Cell Facial is the first of several phytoceutical facials offered at Chernoff Cosmetic Surgeons using advanced growth factors to help improve skin tone, texture, and quality. The treatment is excellent for all skin types including dry, sensitive, acne prone, or compromised skin. Dr. Chernoff recommends his patients use his professional line of GREGORY M.D., Apple Stem Cell Serum for optimal results.

Greg Chernoff, M.D., is a Triple Board Certified Facial Plastic and Reconstructive Surgeon. His practice is dedicated exclusively to aesthetic plastic surgery, hair replacement surgery, cosmetic laser therapy, and all forms medical aesthetics. Dr. Chernoffs laser research has been instrumental in developing and refining accepted laser techniques now utilized by physicians worldwide, and he is at the forefront of research in the areas of fibroblast, stem cell, and regenerative medicine. Dr. Chernoff provides excellent results and outstanding patient care. For more information, contact Chernoff Cosmetic Surgeons at 317-573-8899 http://www.drchernoff.com.

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Chernoff Cosmetic Surgery Pleased to Offer Innovative Phytoceutical Apple Stem Cell Facial