Simultaneous diagnosis and treatment of cancer now possible – Science Daily

Cancer is not incurable anymore. Nevertheless, according to statistics released by Statistics Korea last year, cancer remained the primary cause of mortality in Korea in 2021. This highlights the ongoing struggle against cancer, which demands effective prevention measures as well as timely diagnosis and prompt intervention through effective treatment. However, the question remains whether it is feasible to provide treatment promptly upon diagnosis.

A POSTECH research team led by Professor Young Tae Chang (Department of Chemistry) and Research Professor Nam-Young Kang (Department of Convergence IT Engineering) collaborated with researchers at A*STAR in Singapore to determine the ability of fluorescent probe for tumor-initiating cell yellow (TiY) to stain the cells responsible for tumor growth and simultaneously suppress the growth of those cells. The empirical data of the research was published in the journal Theranostics, which covers treatment, diagnosis, and personalized medicine.

In their previous study, the research team developed fluorescent probe TiY with the ability to selectively identify and detect tumor-initiating cells (TICs), much like a fluorescent highlighter. Building upon this accomplishment, the team has conducted research aimed at exploring the potential of TiY for cancer treatment.

In the present study, the team observed changes in cancer stem cells in response to different concentrations of TiY. The team obtained cancer stem cells from patients with lung cancer and transplanted them into mice for experimental purposes. In order to evaluate the therapeutic effects of TiY staining, the team gradually increased the dose of TiY administered to the mice via intravenous injection in their tests.

When exposed to a low concentration, TiY has been demonstrated to have the ability to stain cancer stem cells. However, as the concentration of TiY increases, it exhibits the remarkable ability to effectively inhibit the growth of cancer stem cells, leading to their substantial destruction. This selective targeting and treatment are made possible by the mechanism of TiY molecules, which have the capacity to selectively bind themselves to vimentin, a muscle-specific protein that is a component of the cytoskeleton of cancer stem cells, thus allowing TiY to specifically target and inhibit these cells of growth.

Current cancer treatments often fail to achieve complete tumor removal, as cancer cells can be metastasized to other organs or recur. Given the challenge, TiY presents a promising approach to cancer treatment as it can facilitate both diagnosis and treatment in a single step

This study was conducted with the support from the Ministry of Science and ICT, the Ministry of Education, the Mid-career Researcher Program of the National Research Foundation of Korea, the Institute of Basic Science, and the NMRC in Singapore.

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Simultaneous diagnosis and treatment of cancer now possible - Science Daily

Mount Sinai Awarded Prestigious $1.3 Million Grant to Expand … – Mount Sinai

The Kimberly and Eric J. Waldman Department of Dermatology at the Icahn School of Medicine at Mount Sinai will expand its research training program in skin biology with support from a five-year, $1.3 million T32 grant from the National Institutes of Health (NIH) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).

The research training program in Systems Skin Biology will take a multidisciplinary approach in teaching scientists to holistically understand human physiology, health, and disease. As a recognized leader in research for skin biology and skin diseases, Mount Sinai will also become an incubator for future biomedical leaders in the field as a result of this program.

Traditional skin biology often focuses on the most obvious cells of the skin, keratinocytes, which form the structure of the epidermis and are essential for skin repair. The Systems Skin Biology program will take an interconnected approach based on the premise that neurons, immune cells, and blood vessels are just as much skin biology as traditional skin cells. Mount Sinai researchers have previously discovered new treatments for itch by studying the intersection of nerves and immune cells, and believe future studies through the Systems Skin Biology program will uncover understandings about wound repair, cancer, hair loss, vitiligo, and acne.

Science and medicine are rapidly evolving, and thus, the training itself must adapt, said co-Principal Investigator Brian S. Kim, MD, MTR, FAAD, Vice Chair of Research and Director of the Mark Lebwohl Center for Neuroinflammation and Sensation at Icahn Mount Sinai. This T32 program is truly unique in that it moves away from focusing on only one discipline, but embraces interdisciplinary training across two traditionally disparate fieldssuch as neuroscience and immunologyby using the skin and associated diseases as a model paradigm.

Dr. Kim, a renowned physician-researcher in chronic itch and inflammatory skin conditions, said the grant (number 1T32AR082315-01) will initially fund two predoctoral fellows or physician-scientists and two postdoctoral fellows or physician-scientists. It will facilitate the training of students toward PhD and/or MD/PhD degrees in intersectional skin biology, as well as training scientists and clinicians with advanced degrees to become independently funded principal investigators. In addition to dermatology, the research training program in Systems Skin Biology will include expertise drawn from across the Health System, including skin biology, immunology, neuroscience, epithelial biology, translational medicine, and stem cell biology.

This training grant will be particularly helpful for pre- and postdoctoral fellows and dermatology residents interested in bringing a new angle and new approaches to skin research, said co-Principal Investigator Sarah E. Millar, PhD, Director of the Black Family Stem Cell Institute and Senior Associate Dean for Basic Research at Icahn Mount Sinai. After training in diverse labs across Mount Sinais campus, they will be able to apply those new skills to uncover novel mechanisms in skin biology and diseases.

This T32 program is one of many steps toward our Department becoming the epicenter of innovation and a world leader in dermatology, as well as in training the future leaders and key opinion thought leaders in dermatology, said Emma Guttman-Yassky, MD, PhD, Waldman Professor of Dermatology and Immunology at Icahn Mount Sinai and Chair of Dermatology at the Mount Sinai Health System. In addition to bringing recognition of the breadth of institutional excellence in cutaneous diseases and skin biology at Mount Sinai, this training program will have an indelible impact on the future of dermatology and dermatology research for decades to come.

Mount Sinai continues to be a leader in the field of skin biology throughout New York City and the tri-state region. In 2021, the Health System established a Skin Biology and Diseases Resource-based Centerthen one of only six nationwide supported by a NIAMS grant. The Center uses technical innovations, high-end infrastructure, and computing power available at Mount Sinai to advance and support skin research; it also embeds experts in gene editing, genomics, and bioinformatics within skin research labs to break down interdisciplinary communication barriers.

About the Icahn School of Medicine at Mount Sinai

The Icahn School of Medicine at Mount Sinai is internationally renowned for its outstanding research, educational, and clinical care programs. It is the sole academic partner for the eight member hospitals* of the Mount Sinai Health System, one of the largest academic health systems in the United States, providing care to a large and diverse patient population.

Ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges, Icahn Mount Sinai has a talented, productive, and successful faculty. More than 3,000 full-time scientists, educators, and clinicians work within and across 34 academic departments and 44 multidisciplinary institutes, a structure that facilitates tremendous collaboration and synergy. Our emphasis on translational research and therapeutics is evident in such diverse areas as genomics/big data, virology, neuroscience, cardiology, geriatrics, and gastrointestinal and liver diseases.

Icahn Mount Sinai offers highly competitive MD, PhD, and masters degree programs, with current enrollment of approximately 1,300 students. It has the largest graduate medical education program in the country, with more than 2,600 clinical residents and fellows training throughout the Health System. In addition, more than 535 postdoctoral research fellows are in training within the Health System.

A culture of innovation and discovery permeates every Icahn Mount Sinai program. Mount Sinais technology transfer office, one of the largest in the country, partners with faculty and trainees to pursue optimal commercialization of intellectual property to ensure that Mount Sinai discoveries and innovations translate into health care products and services that benefit the public.

Icahn Mount Sinais commitment to breakthrough science and clinical care is enhanced by academic affiliations that supplement and complement the Schools programs. Through Mount Sinai Innovation Partners (MSIP), the Health System facilitates the real-world application and commercialization of medical breakthroughs made at Mount Sinai. Additionally, MSIP develops research partnerships with industry leaders such as Merck & Co., AstraZeneca, Novo Nordisk, and others.

The Icahn School of Medicine at Mount Sinai is located in New York City on the border between the Upper East Side and East Harlem, and classroom teaching takes place on a campus facing Central Park. Icahn Mount Sinais location offers many opportunities to interact with and care for diverse communities. Learning extends well beyond the borders of our physical campus, to the eight hospitals of the Mount Sinai Health System, our academic affiliates, and globally.

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* Mount Sinai Health System member hospitals: The Mount Sinai Hospital; Mount Sinai Beth Israel; Mount Sinai Brooklyn; Mount Sinai Morningside; Mount Sinai Queens; Mount Sinai South Nassau; Mount Sinai West; and New York Eye and Ear Infirmary of Mount Sinai.

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Mount Sinai Awarded Prestigious $1.3 Million Grant to Expand ... - Mount Sinai

Global Cell Culture Market Report 2023: Government Support and Funding for Cell-Based Research Bolsters Growth – Yahoo Eurosport UK

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Global Cell Culture Market

Global Cell Culture Market

Dublin, April 04, 2023 (GLOBE NEWSWIRE) -- The "Global Cell Culture Market by Product (Consumables (Media, Sera, Reagent), Vessel (Roller bottle, Cell Factory), Equipment (Bioreactor, Centrifuges, Incubators)), Application (mAbs, Vaccines, Diagnostics, Tissue Engineering), End User - Forecasts to 2028" report has been added to ResearchAndMarkets.com's offering.

The global cell culture market is projected to reach USD 51.3 billion by 2028 from USD 27.9 billion in 2023, at a CAGR of 12.9% during the forecast period of 2023 to 2028. The growth of this market is majorly driven by the adoption of single-use technologies, growing focus on product development, growing popularity of monoclonal antibodies, and growth in cell and gene therapies and stem cell research. On the other hand, the high cost of cell biology research is restraining the growth of this market.

The supporting equipment sub-segment accounted for the largest share of the equipment segment during the forecast period

By product, the supporting equipment sub-segment accounted for the largest share of the equipment segment. Cell culture supporting equipment includes filtration systems, cell counters, carbon dioxide incubators, centrifuges, autoclaves, microscopes, biosafety cabinets, and other supporting equipment such as pipetting aids, pipettes, cell inserts, cell scrapers, cell lifters, cell spreaders, pH meters, shakers, flow cytometers, and water baths. These equipment play a vital role in maintaining optimum cell culture conditions. The increasing focus on cancer research, cell-based research and stem-cell research coupled with the rising need to meet the GMP standards and regulations is expected to fuel the segment market growth.

Europe: The second largest region in the cell culture market

Factors such as the increasing incidence of chronic diseases, rising government investments in life sciences, and increasing focus on stem cell research and regenerative medicine are driving the growth of the cell culture market in Europe. Moreover, several conferences, symposia, seminars, trade fairs, annual events, and workshops are being organized in Europe to create awareness of cell culture products.

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Market Dynamics

Drivers

Government Support and Funding for Cell-Based Research

Emerging Cell Culture Technologies for Cell-Based Vaccines

Growing Popularity of Monoclonal Antibodies

Adoption of Single-Use Technologies

Growing Focus on Product Development

Growth in Cell and Gene Therapies and Stem Cell Research

Incidence of Infectious Diseases

Restraints

Opportunities

Demand for 3D Over 2D Cell Cultures

Growth Hotspots in Emerging Economies

Challenges

Disposal of Plastic Consumables

Key Attributes:

Report Attribute

Details

No. of Pages

692

Forecast Period

2022 - 2027

Estimated Market Value (USD) in 2022

$27.9 Billion

Forecasted Market Value (USD) by 2027

$51.3 Billion

Compound Annual Growth Rate

12.9%

Regions Covered

Global

Key Topics Covered:

1 Introduction

2 Research Methodology

3 Executive Summary

4 Premium Insights

5 Market Overview

6 Cell Culture Market, by Product6.1 IntroductionTable 18 Market, by Product, 2020-2028 (USD Million)6.2 Consumables6.2.1 Sera, Media, and Reagents6.2.2 Vessels6.2.3 Accessories6.3 Equipment6.3.1 Supporting Equipment6.3.2 Bioreactors6.3.3 Storage Equipment

7 Cell Culture Market, by Application7.1 IntroductionTable 277 Market, by Application, 2020-2028 (USD Million)7.2 Biopharmaceutical Production7.2.1 Monoclonal Antibody Production7.2.2 Vaccine Production7.2.3 Other Therapeutic Protein Production7.3 Diagnostics7.4 Drug Screening & Development7.5 Tissue Engineering & Regenerative Medicine7.5.1 Cell & Gene Therapy7.5.2 Other Tissue Engineering & Regenerative Medicine Applications7.6 Other Applications

8 Cell Culture Market, by End-user8.1 IntroductionTable 330 Cell Culture Market, by End-user, 2020-2028 (USD Million)8.2 Pharmaceutical & Biotechnology Companies8.3 Hospitals & Diagnostic Laboratories8.4 Research & Academic Institutes8.5 Other End-users

9 Cell Culture Market, by Region

10 Competitive Landscape

11 Company Profiles

12 Appendix12.1 Discussion Guide12.2 Knowledgestore: The Subscription Portal12.3 Customization Options

Companies Mentioned

Thermo Fisher Scientific Inc. (US)

Merck KGaA (Germany)

Danaher Corporation (US)

Corning Incorporated (US)

Eppendorf AG (Germany)

FUJIFILM Irvine Scientific, Inc. (Japan)

Lonza Group AG (Switzerland)

Sartorius AG (Germany)

Agilent Technologies, Inc. (US)

Getinge AB (Sweden)

Becton, Dickinson and Company (US)

Miltenyi Biotec (Germany)

HiMedia Laboratories (India)

STEMCELL Technologies Inc. (Canada)

Solida Biotech GmbH (Germany)

Caisson Laboratories Inc. (US)

PromoCell GmbH (Germany)

InvivoGen (US)

Pan-Biotech GmbH (Germany)

Cellexus (UK)

Meissner Filtration Products Inc. (US)

Adolf Kuhner AG (Switzerland)

SeraCare Life Sciences Inc. (US)

ANGUS Chemical Company (US)

Biospherix Ltd. (US)

For more information about this report visit https://www.researchandmarkets.com/r/vej4w1

About ResearchAndMarkets.comResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

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Global Cell Culture Market Report 2023: Government Support and Funding for Cell-Based Research Bolsters Growth - Yahoo Eurosport UK

The Most Lasting Damage of the Bush Era Was Not the Iraq War – The New Republic

I have no doubt theres a few dissertations worth ofargument about exactly why political consensus around the war and consensusaround bodily autonomy had such disparate trajectories. Ultimately, it justseems like stories about dead soldiers and the constantly shifting foreignpolicy objectives that doomed them have an effect that stories about desperatewomen and an advancing medical dystopia dont.

For fans of American military bluster, the fantasy of theIraq adventure ran up against the reality of broken bodies and wasted billions a few years into the project, spelled out by the media with a remarkable lackof self-awareness and institutional memory. Democrats quickly and Republicanswith less haste recognized over time the human and material cost of theirdecision and changed their position accordingly.

Thats just not how its gone with the hellscape created byshrinking access to reproductive care. Im sure thats in part because the catastrophehas happened in ways and to people that allowed potentially persuadableRepublicans and, lets face it, most Democrats and the chattering class to ignoreit. Roe fell in America not with the Dobbs decision but instages, beginning with the most vulnerable Americans, until the curtain finallyfell on everyone else.

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The Most Lasting Damage of the Bush Era Was Not the Iraq War - The New Republic

NYC Mayor Eric Adams Joined Top Biomedical Researchers to … – Mount Sinai

The grand opening of the Center for Engineering and Precision Medicine (CEPM), a partnership between Rensselaer Polytechnic Institute (RPI) and the Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai), was held yesterday at the Hudson Research Center (HRC) at 619 West 54th Street.

The center is the latest in a 10+ year partnership between RPI, a world-renowned technological research university known for its engineering, technology, and science programs, and Icahn Mount Sinai, the academic arm of the Mount Sinai Health System, which includes eight hospitals and a vast network of ambulatory practices throughout the greater New York City region. The HRC is a 320,000-square-foot, mixed-use hub for innovation in New York Citys growing life sciences sector.

We are thrilled to open the doors to the Center for Engineering and Precision Medicine, said Rensselaer President Martin A. Schmidt, Ph.D. CEPM will transform the diagnosis and treatment of cancer, Alzheimers, infectious diseases, and more by advancing state-of-the-art technologies and focusing on a personalized approach. CEPM, the third of RPIs New York City-based research centers, will also provide exceptional educational opportunities for the next generation of researchers, medical professionals, and life sciences entrepreneurs.

Leveraging the strength of RPI and Icahn Mount Sinai, CEPM bridges research, technology development and commercialization, and education. CEPM is one of the first life science centers of its kind in New York City and the nation to integrate engineering and biomedical sciences with education, training, and research collaborations to radically improve human health.

CEPM is built on the tenet that engineering is fundamental to understanding biomedical phenomena and developing the next generation of precision diagnostics and therapeutics for human health and well-being. RPI and Icahn Mount Sinai are well-positioned to seamlessly integrate research and education in engineering with medicine and transform personalized medicine. Critically, a major distinguishing feature of CEPM is the immense diversity in patients within the Mount Sinai Health System. This diversity, together with the analytical capabilities of engineering, is critical in advancing precision medicine.

The Center for Engineering and Precision Medicine combines the biomedical excellence of Icahn Mount Sinai with the engineering expertise of RPI to create an academic research hub that will make fundamental discoveries and develop new treatments that will improve the lives of patients suffering from the most complex diseases, said Dennis S. Charney, M.D., the Anne and Joel Ehrenkranz Dean of Icahn Mount Sinai.

Housed in 23,000 square feet of lab space on the 9th floor of the HRC, CEPM will benefit from the areas abundance of research talent and is in the process of recruiting faculty and staff. The space provides both wet lab and dry lab capabilities with high-performance computational infrastructure to seamlessly perform complex experiments and build advanced technologies to diagnose, treat, and manage diseases at a patients level. Office space and open cubicles surround the lab space to create a cohesive and collaborative research environment to promote interdisciplinary teamwork.

The Center for Engineering and Precision Medicine is more than a hub for research and education its a bridge to the future, said New York City Mayor Eric Adams. Our administration is harnessing the momentum of the life sciences industry to create access to next-generation jobs for everyone. Last year, Governor Hochul and I announced SPARC Kips Bay, an education and innovation hub that will be the first of its kind in New York City, which will generate $25 billion in economic impact to the city and create 10,000 jobs. Together, we are going to make sure New York City leads the globe in life sciences.

The New York Stem Cell Foundation (NYSCF) Research Institute, a nonprofit organization with a mission to accelerate cures for the major diseases of our time, is on the second and third floors of the HRC. Stem cell research plays a critical role in engineering tissue repair and in developing various cell types for drug discovery screening.

These two institutions are widely recognized leaders in engineering and medicine, and we are delighted to welcome the Center for Engineering and Precision Medicine to the Hudson Research Center by hosting the grand opening event, said Derrick Rossi, Ph.D., Interim CEO of NYSCF. The synergies between NYSCFs stem cell biology and the engineering and medical expertise at CEPM will lead to new and important collaborations to accelerate discoveries that directly reach patients.

Speakers included Schmidt and Charney, Mayor Adams, Senator Charles Schumer and Senator Kirsten Gillibrand (via video), and New York City Economic Development Corporation (NYCEDC) President and CEO Andrew Kimball.

As we continue to establish New York City as the leader in the life sciences industry, we must continue to bolster innovation that will create new jobs and spur meaningful research, said Kimball. The Center for Engineering and Precision Medicine will uniquely bridge biology, health care, and technology to advance cutting-edge discoveries and accelerate breakthrough treatment for intractable diseases, advancing individualized treatment, and improving quality of life for all New Yorkers. We are excited to continue working with our partners to spark new opportunities in this rapidly growing industry.

The keynote speakers were Rossi and Roderic I. Pettigrew, Ph.D., M.D., CEO of Engineering Health and Executive Dean for Engineering Medicine at Texas A&M University, in partnership with Houston Methodist Hospital.

Additional speakers included CEPM Co-Directors Jonathan Dordick, Ph.D., Institute Professor of Chemical and Biological Engineering, Biomedical Engineering, and Biological Sciences at Rensselaer; and Priti Balchandani, Ph.D., Professor of Diagnostic, Molecular and Interventional Radiology, Neuroscience, and Psychiatry at Icahn Mount Sinai; as well as Deepak Vashishth, Ph.D., Director of the Center for Biotechnology and Interdisciplinary Studies at Rensselaer and CEPM Associate Director.

The Center for Engineering and Precision Medicine will enable breakthroughs in neuromodulation, immune resilience, and regenerative and reparative medicine, said CEPM Co-Director Dordick. We will give top talent with ambitious ideas the resources they need to more effectively advance personalized medicine to address intractable diseases and benefit patients.

CEPM represents the evolution of a successful partnership between Mount Sinai and Rensselaer that has secured over $80 million in shared research funding since 2013. CEPM will drive advances in point-of-care and point-of-use devices and diagnostics; microphysiological platforms for discovery and diagnosis; robotic surgery; biomedical imaging; therapeutics biomanufacturing; and artificial intelligence and machine learning applied to biomedical data.

The Center for Engineering and Precision Medicine is creating a direct opportunity for exceptional engineers to apply their knowledge and skill toward the transformation of medicine and improvement of human health, said CEPM Co-Director Balchandani.

CEPM will offer a joint Ph.D. to train students in engineering medicine with expertise in reparative medicine, and neuro- and immuno- engineering through educational courses and research training. It will involve immersions in engineering, entrepreneurship and commercialization, and clinical rotation and shadowing to create a translational mindset at the onset of the program and produce a new breed of Ph.D.s capable of inventing new technologies to address unmet clinical needs. The development of certificate programs will broaden CEPMs academic mission and facilitate entrepreneurship and commercialization of advanced technologies and medical devices.

The Center for Engineering and Precision Medicine presents exciting opportunities for researchers, students, and, ultimately, patients, said Vashishth. The treatments and technologies developed at CEPM will decrease side effects and increase effectiveness for patients and usher an inclusive and healthier future for medicine and health care.

We are proud to welcome Rensselaer and Mount Sinai as they launch the new Center for Engineering and Precision Medicine in the Hudson Research Center, said Matthew Weir, President of Elevate Research Properties. This new center will serve as an important anchor for the growing New York City research ecosystem.

About Rensselaer Polytechnic Institute:

Founded in 1824, Rensselaer Polytechnic Institute is Americas first technological research university. Rensselaer encompasses five schools, over 30 research centers, more than 140 academic programs, including 25 new programs, and a dynamic community comprised of over 6,800 students and 104,000 living alumni and alumnae. Rensselaer faculty and graduates include upward of 155 National Academy members, six members of the National Inventors Hall of Fame, six National Medal of Technology winners, five National Medal of Science winners, and a Nobel Prize winner in Physics. With nearly 200 years of experience advancing scientific and technological knowledge, Rensselaer remains focused on addressing global challenges with a spirit of ingenuity and collaboration. To learn more, please visit http://www.rpi.edu.

About the Icahn School of Medicine at Mount Sinai:

The Icahn School of Medicine at Mount Sinai is internationally renowned for its outstanding research, educational, and clinical care programs. It is the sole academic partner for the eight member hospitals* of the Mount Sinai Health System, one of the largest academic health systems in the United States, providing care to a large and diverse patient population. Ranked 14th nationwide in National Institutes of Health (NIH) funding and among the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges, Icahn Mount Sinai has a talented, productive, and successful faculty. More than 3,000 full-time scientists, educators and clinicians work within and across 34 academic departments and 35 multidisciplinary institutes, a structure that facilitates tremendous collaboration and synergy. Our emphasis on translational research and therapeutics is evident in such diverse areas as genomics/big data, virology, neuroscience, cardiology, geriatrics, as well as gastrointestinal and liver diseases. Icahn Mount Sinai offers highly competitive MD, PhD, and Masters degree programs, with current enrollment of approximately 1,300 students. It has the largest graduate medical education program in the country, with more than 2,000 clinical residents and fellows training throughout the Health System. In addition, more than 550 postdoctoral research fellows are in training within the Health System. To learn more, please visit https://icahn.mssm.edu/.

About Taconic Partners:

Since 1997, Taconic Partners has acquired, redeveloped and repositioned over 12 million square feet of commercial office and mixed-use space, as well as over 6,500 units of luxury and workforce housing. As a fully integrated real estate company with a keen eye for uncovering value, its diverse capabilities are evidenced by its multifaceted success with luxury properties, as well as adaptive reuse and urban revitalization projects. In New York City, Taconic is advancing over 650,000 square feet of life sciences space at 125 West End Avenue as well as at the Hudson Research Center at 619 West 54th Street. Other active Taconic projects include 817 Broadway, 311 West 42nd Street and Essex Crossing on the Lower East Side. The firm also manages various real estate funds on behalf of institutional and pension fund investors. For more information visit: http://www.taconicpartners.com

About Silverstein Properties:

Silverstein Properties is a privately held, full-service real estate development, investment and management firm based in New York. Founded in 1957 by Chairman Larry Silverstein, the company has developed, owned and managed more than 40 million square feet of commercial, residential, retail and hotel space. Recent projects include 7 World Trade Center, the first LEED-certified office tower in New York City (2006), 4 World Trade Center (2013), the Four Seasons Downtown (2016), One West End (2017) and 3 World Trade Center (2018). The company has been recognized as one of the Best Places to Work in New York City by Crains New York Business for eight years in a row. For further information on Silverstein Properties, please visit http://www.silversteinproperties.com.

About New York Stem Cell Foundation Research Institute:

The New York Stem Cell Foundation (NYSCF) Research Institute is an independent non-profit organization accelerating cures and better treatments for patients through stem cell research. The NYSCF global community includes over 200 researchers at leading institutions worldwide, including the NYSCF Druckenmiller Fellows, the NYSCF Robertson Investigators, the NYSCF Robertson Stem Cell Prize Recipients, and NYSCF Research Institute scientists and engineers. The NYSCF Research Institute is an acknowledged world leader in stem cell research and in the development of pioneering stem cell technologies, including the NYSCF Global Stem Cell Array, which is used to create cell lines for laboratories around the globe. NYSCF focuses on translational research in an accelerator model designed to overcome barriers that slow discovery and replace silos with collaboration.

Contact: Rensselaer Polytechnic InstituteKatie Malatinomalatk@rpi.edu838-240-5691

Mount SinaiKarin Eskenazikarin.eskenazi@mssm.edu332-257-1538

Taconic Partners/Silverstein PropertiesJohann Hamiltonjohann@relevanceinternational.com917-887-1750

New York Stem Cell FoundationDavid McKeondmckeon@nyscf.org212-365-7440

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NYC Mayor Eric Adams Joined Top Biomedical Researchers to ... - Mount Sinai

Mouse study at USC reveals why leukemic mutation varies – Drug Target Review

A mechanism linked to a genetic mutation could help identify patients who are at higher risk of developing leukaemia.

A new study published inBlood, focuses on a genetic mutation associated with leukaemia. While some individuals with this mutation remain healthy, others develop the disease. The researchers at the USC Stem Cell laboratory, US, found a mechanism linked to this mutation, which could help identify patients who are at higher risk of developing leukaemia.

The new study, which focused on a genetic mutation associated with leukaemia found a mechanism linked to this mutation, could help identify patients who are at higher risk of developing leukaemia. While some individuals with this mutation remain healthy, others are at higher risk of developing the disease.

The study involved tracking individual blood stem cells in mice with a specific genetic mutation, called TET2, which is commonly found in patients with myeloid leukaemia. The researchers discovered that certain blood stem cells, known as clones, contributed more to the overall population of blood and immune cells. These clones tended to produce many myeloid cells, including immune cells called granulocytes, which could potentially lead to myeloid leukaemia.

Significant differences were found in the gene activity of the over-contributing clones in comparison to the other clones. Specifically, the over-contributing clones showed decreased activity in various genes known to prevent the development of leukaemia and other cancers. They also exhibited reduced activity in genes involved in RNA splicing, a process that removes non-coding sequences from RNA messages that are responsible for protein production in cells.

The research team identified one RNA splicing gene, Rbm25, that displayed a considerable reduction in its activity within the over-contributing clones. To explore the effect of Rbm25, the scientists used CRISPR-Cas9 gene manipulation to increase or decrease Rbm25 activity in cells with TET2 mutations. Results indicated that boosting Rbm25 activity slowed cell proliferation, while reducing it caused cells to multiply more rapidly and caused alterations in RNA splicing of the gene Bcl2l1, which regulates programmed cell death or apoptosis. Apoptosis is a crucial process that removes abnormal cells from the body, such as pre-cancerous cells that rapidly multiply and produce dangerous mutations that could result in illness.

The recent findings in mice suggest that Rbm25 activity has a negative correlation with the count of white blood cells, which is an indicator of poor prognosis in individuals diagnosed with myeloid leukaemia.

Our study suggests that a leukaemia-associated genetic mutation could trigger different amounts of myeloid cell production, which may be modulated by other risk factors such as RNA splicing regulators, said Associate Professor Rong Lu, from USC, and a Leukaemia & Lymphoma Society Scholar. These findings could be used to better stratify which patients are at the highest risk, and also present intriguing possibilities for developing future therapies that target aberrant RNA splicing in pre-leukaemia phases.

Following the latest findings in mice, it has been observed that Rbm25 activity is inversely related to the number of white blood cells, which is an indicator of poor survival in human patients diagnosed with myeloid leukaemia.

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Mouse study at USC reveals why leukemic mutation varies - Drug Target Review

Exploring The Donor-Derived CAR T-Cell Therapy, ALLO-501A – Targeted Oncology

Michael T. Tees, MD, an associate member physician at the Colorado Blood Cancer Institute and part of the Lymphoid and Autoimmune Disease Groups, discusses chimeric antigen receptor (CAR) T-cell therapies, including ALLO-501A, and its use for patients with relapsed or refractory large B-cell lymphoma (LBCL).

ALLO-501A is an anti-CD19 allogeneic CAR T-cell product with a disrupted TCR gene and an edited CD52 gene. Based on early research, the agent may reduce the risk of graft-versus-host disease, and allow the use of the humanized anti-CD52 mAb, ALLO-647 to decrease the number of host T cells for patients.

The agent was first evaluated in the ALPHA1 study (NCT03939026) where no dose modifications or dose-limiting toxicities were observed, and the most common adverse events (AEs) reported consisted of anemia, leukopenia, neutropenia, and thrombocytopenia (73%), and lymphopenia (64%). Then, the ALPHA2, (NCT04416984) study continued to explore the safety and efficacy of ALLO-501A in patients with relapsed/refractory LBCL.

TRANSCRIPTION:

0:08 | CAR T-cell therapy has been around for quite some time. It's been about 5 years since the first CAR T product was approved by the FDA, which was an autologous product. It's the patient's own cells that are genetically re-engineered to recognize that the cancer is foreign. Typically, it's CD19.

0:37 | ALLO-501A is a clinical trial evaluating not autologous CAR T cells, but allogeneic CAR T cells using cells from a donor population to achieve the same effect as using your own cells. [There are multiple reasons] why this is important to investigators. Primarily, there is a lag time between when we need to collect those donor cells and send them away for re-engineering until we can do the treatment for the patient. That lag time can be dangerous and potentially deadly for those patients who have refractory diseases. Having an off-the-shelf product ready to go, if it's safe, is key. We would not have the potential 3-to-4-week lag time of the processing and collection, which is extremely important.

1:54 | What we're also seeing now is a backlog for the products that are commercially available because they can't keep up with that demand. With this agent, the product is ready to go from a different donor with comparable benefit and efficacy, and ideally, an even better safety profile would make this the ideal situation.

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Rich Insights into the Heart Failure Clinical Trial Analysis Featuring … – PR Newswire

Currently, much research is ongoing to develop new and effective therapeutic drugs for the treatment of Heart failure. The treatment of HF is dependent on angiotensin-converting enzyme inhibitor, angiotensin receptor II blocker, beta-blockers, and diuretics. Additionally, other therapies, such as aldosterone antagonists, amiodarone, antiaggregants, anticoagulants, calcium antagonists, diuretics, nitrates, among others are used for the treatment of patients affected by heart failure. Biomarkers provide a low cost, low risk, and quick turnaround method to confirm or exclude a HF diagnosis, help to establish prognosis in the diagnosis, and more fundamentally, may provide substantial information on the complex pathophysiology that defines the syndrome of HF.

LAS VEGAS, April 4, 2023 /PRNewswire/ --DelveInsight's 'Heart Failure Pipeline Insight 2023'report provides comprehensive global coverage of available, marketed, and pipeline heart failure therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the heart failure pipeline domain.

Key Takeaways from the Heart Failure Pipeline Report

Request a sample and discover the recent advances in heart failure drug treatment @ Heart Failure Pipeline Report

The heart failure pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage heart failure drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the heart failure clinical trial landscape.

Heart Failure Overview

Heart failure is a syndrome caused by structural and functional defects in the myocardium that impair ventricular filling or blood ejection. Reduced left ventricular myocardial function is the most common cause of heart failure. Increased hemodynamic overload, ischemia-related dysfunction, ventricular remodeling, excessive neuro-humoral stimulation, abnormal myocyte calcium cycling, excessive or inadequate extracellular matrix proliferation, accelerated apoptosis, and genetic mutations are major pathogenic mechanisms leading to heart failure. Heart failure can significantly reduce a patient's functional capacity and increase the risk of death. Diagnosing and treating the disease effectively is critical to avoid recurrent hospitalizations, improve quality of life, and improve patient outcomes.

Heart failure treatment necessitates a multifaceted approach that includes patient education, an optimal medical regimen to improve cardiac contractility, and the prevention/limitation of exacerbations. The primary heart failure symptoms are dyspnea and fatigue, which can limit exercise tolerance and lead to pulmonary and splanchnic congestion and peripheral edema. Heart failure is still a difficult problem and is now regarded as the most difficult challenge in cardiovascular medicine and surgery.

Find out more about drugs for heart failure @ New Heart Failure Drugs

A snapshot of the Heart Failure Pipeline Drugs mentioned in the report:

Drugs

Company

Phase

MoA

RoA

Tirzepatide

Eli Lilly and Company

Phase III

Gastric inhibitory polypeptide receptor agonists; Glucagon like peptide 1 receptor agonists

Subcutaneous

Finerenone (BAY94-8862)

Bayer

Phase III

Mineralocorticoid receptor antagonists

Oral

Firibastat

Quantum Genomics

Phase II

Glutamyl aminopeptidase inhibitors

Oral

HU 6

Rivus Pharmaceuticals

Phase II

Metabolism stimulants

Oral

Elamipretide

Stealth BioTherapeutics

Phase II

Cardiolipin modulators; Free radical scavengers; Mitochondrial permeability transition pore inhibitors

Subcutaneous

TN-301

Tenaya Therapeutics

Phase I

HDAC6 protein inhibitors

Oral

Learn more about the emerging heart failure pipeline therapies @ Heart Failure Clinical Trials

Heart Failure Therapeutics Assessment

Theheart failure pipelinereport proffers an integral view of heart failure emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration.

Scope of the Heart Failure Pipeline Report

Dive deep into rich insights for new drugs for heart failure treatment; visit@ Heart Failure Medications

Table of Contents

1.

Heart Failure Pipeline Report Introduction

2.

Heart Failure Pipeline Report Executive Summary

3.

Heart Failure Pipeline: Overview

4.

Analytical Perspective In-depth Commercial Assessment

5.

Heart Failure Clinical Trial Therapeutics

6.

Heart Failure Pipeline: Late Stage Products (Pre-registration)

7.

Heart Failure Pipeline: Late Stage Products (Phase III)

8.

Heart Failure Pipeline: Mid Stage Products (Phase II)

9.

Heart Failure Pipeline: Early Stage Products (Phase I)

10.

Heart Failure Pipeline Therapeutics Assessment

11.

Inactive Products in the Heart Failure Pipeline

12.

Company-University Collaborations (Licensing/Partnering) Analysis

13.

Key Companies

14.

Key Products in the Heart Failure Pipeline

15.

Unmet Needs

16.

Market Drivers and Barriers

17.

Future Perspectives and Conclusion

18.

Analyst Views

19.

Appendix

For further information on the heart failurepipeline therapeutics, reach out @ Heart FailureDrug Treatment

Related Reports

Heart Failure Market

Heart Failure Market Insights, Epidemiology, and Market Forecast 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key heart failure companies, including Help Therapeutics, Heartseed, HAYA Therapeutics, GlaxoSmithKline, GB Sciences, Fujifilm Corporation, Evotec SE, Eli Lilly and Company, Edgewise Therapeutics, among others.

Heart FailureEpidemiology Forecast

Heart Failure Epidemiology Forecast 2032report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, and heart failureepidemiology trends.

Advanced Heart Failure Pipeline

Advanced Heart Failure Pipeline Insight 2023report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the keyadvanced heart failurecompanies, including Sana Biotechnology, Salubris Biotherapeutics, Roche, Rivus Pharmaceuticals, Ribomic, Renova Therapeutics, Relaxera, among others.

Chronic Heart Failure Pipeline

Chronic Heart Failure Pipeline Insight 2023report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the keychronic heart failurecompanies, including Zensun (Shanghai) Sci & Tech, Cytokinetics, Mesoblast, Shanghai Hongyitang Biopharmaceutical Technology, Tasly Pharmaceuticals, among others.

Acute Heart Failure Pipeline

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Rich Insights into the Heart Failure Clinical Trial Analysis Featuring ... - PR Newswire

Timing is everything – ASBMB Today

Congratulations on the acceptance of your manuscript.

It was strange to read this, since the project almost never happened.

Two years and seven months earlier, only sunlight illuminated the dim, silent hallway and adjoining quiet lab spaces. I hastened down the hall, slowing only to glance at flyers advertising seminars from March 2020. A month outdated, they were a relic from the time before COVID-19 froze academic life, despite the initial drumbeat of We will remain open.

Teisha Rowland

Much of the work Teisha Rowland, left, did to guide her student Ashlynn through her undergraduate research project had to be done remotely.

As the stem cell centers director, Id become what the university termed an essential worker, tasked with minding the centers frozen cell bank. While checking the cryogenic tank, I glanced at Ashlynns empty desk.

Ashlynn was an impressive undergraduate assistant; we wanted to start a research project. It would use human induced pluripotent stem cells, or iPSCs the centers specialty to investigate whether the extracellular matrix impacts cardiomyocyte differentiation.

Like many labs, we were pivoting. We were thrilled that Ashlynns summer research proposal had been approved but chose to delay funding until fall 2020.

We decided a remote literature review project would be best, helping prepare Ashlynn for bench research in the fall. This is going to be an incredible learning experience for me, Ashlynn raved.

With few funding options as a director, I was grateful for departmental professional development funds for her stipend.

Over the summer, Ashlynn made great progress on the literature review. We met twice a week via Zoom and exchanged many emails to discuss papers and flesh out the manuscript. At the summers end, we passed the manuscript torch to another undergraduate researcher, Tessa.

Ashlynn meanwhile attended one of the centers iPSC training workshops and then dug into her research in the lab that fall. Armed with a protocol we reviewed remotely, she finally tried the differentiation.

I remember going into the lab, excited to check on her cells. Carefully taking the plate from the incubator, I set it on the microscope and searched for cells. My heart may have skipped a beat when I saw Ashlynns cardiac cells contracting. She had successfully executed the protocol, on her own, on her first try.

By April 2021, research was mostly back to normal, but now our clock was ticking. After two years as the centers founding director, I was ready for new career adventures, but Ashlynns project was unfinished.

We selected extracellular matrix proteins and planned out our best-shot experiment.

And it worked. Sitting with Ashlynn in the centers dark, cozy fluorescence microscopy room, I gave her a crash course on collecting images. She continued collecting images after I left that day. With those and her detailed notes, it would have to be enough and amazingly, it was.

Ashlynn graduated in spring 2022 with an honors thesis built upon these experiments. That fall, we wrapped up the literature review, including Ashlynns data, and after peer review, it was published.

I was honored that, despite a pandemic, I published with an undergraduate listed as first author.

(The manuscript Teisha Rowland writes about here with multiple undergraduate co-authors was published in the journal Bioengineering.)

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Timing is everything - ASBMB Today

One Stem Cell Injection to Target Inflammation Slashed Risk of … – Good News Network

Dr. Perin holds up the stem cell treatment Texas Heart Institute

A large trial showed that a single injection of a patients own stem cells into their heart was able to reduce inflammation and risk of heart attack and stroke by 58% if they had heart failure.

6 million Americans have clinical diagnoses of heart failure, a condition designated by a lack of ability for the heart to pump blood sufficiently.

For the first time, weve discovered that stem cells can successfully treat the inflammation that causes heart failure, study lead author Dr. Emerson Perin, told the European Pharmaceutical Review.

Its the largest clinical trial of cell therapy for heart disease to date and demonstrated several positive results. Before understanding the cure, its worth taking a moment to understand the problem.

When less than 40% of the blood inside the heart is pumped out into the body, an individual has heart failure, and could in theory at any moment suffer a cardiovascular event like a heart attack. This is called left ventricular ejection fraction (LVEF), with a healthy persons fraction being 55%-70%.

Because inflammation is closely associated with heart diseaseboth arise from the same poor lifestyle patterns which cause the majority of cases of heart diseasecardiologists at the Texas Heart Institute designed a treatment that could address the inflammation.

What they selected were stem cells taken from a patients bone marrow called mesenchymal precursor cells, which are replicated in a lab via proprietary methods developed by a pharmaceutical company called Mesoblast, and injected straight into the heart.

MORE NEWS ON STEM CELLS: Sound Waves Convert Stem Cells Into Bone in Regenerative Breakthrough

First and foremost, the treatment, called rexlemestrocel-L, was well-tolerated and didnt cause additional inflammation in any patients who received it. Secondly, the treated patients showed increased performance of LVEF; their hearts were pumping out more blood volume.

We are very encouraged by these study data that indicate the potential of our allogeneic cellular therapy to address the major areas of unmet need in heart failure patients where conventional treatments are not effective, said Mesoblast CEO Dr. Silviu Itescu in a statement.

MORE NEWS ON STEM CELLS: Yale Scientists Successfully Repair Injured Spinal Cords Using Patients Own Stem Cells

Improvement in LVEF at 12 months may be a functional surrogate endpoint for rexlemestrocel-Ls subsequent benefits on long-term MACE outcomes and survival in this high-risk patient population with chronic heart failure.

The trial was a phase 3, double-blinded, placebo-controlled trial, i.e. the gold standard for medicine, and it should open up the door to future trials of the same kind and turn the research into real treatments for thousands of people.

SHARE This Encouraging Study Result With Your Friends

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One Stem Cell Injection to Target Inflammation Slashed Risk of ... - Good News Network