Stem Cell Clinic

Bone Marrow Transplantation and Peripheral Blood Stem Cell …

By Stem Cell Treatment

What are bone marrow and hematopoietic stem cells?

Bone marrow is the soft, sponge-like material found inside bones. It contains immature cells known as hematopoietic or blood-forming stem cells. (Hematopoietic stem cells are different from embryonic stem cells. Embryonic stem cells can develop into every type of cell in the body.) Hematopoietic stem cells divide to form more blood-forming stem cells, or they mature into one of three types of blood cells: white blood cells, which fight infection; red blood cells, which carry oxygen; and platelets, which help the blood to clot. Most hematopoietic stem cells are found in the bone marrow, but some cells, called peripheral blood stem cells (PBSCs), are found in the bloodstream. Blood in the umbilical cord also contains hematopoietic stem cells. Cells from any of these sources can be used in transplants.

What are bone marrow transplantation and peripheral blood stem cell transplantation?

Bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT) are procedures that restore stem cells that have been destroyed by high doses of chemotherapy and/or radiation therapy. There are three types of transplants:

Why are BMT and PBSCT used in cancer treatment?

One reason BMT and PBSCT are used in cancer treatment is to make it possible for patients to receive very high doses of chemotherapy and/or radiation therapy. To understand more about why BMT and PBSCT are used, it is helpful to understand how chemotherapy and radiation therapy work.

Chemotherapy and radiation therapy generally affect cells that divide rapidly. They are used to treat cancer because cancer cells divide more often than most healthy cells. However, because bone marrow cells also divide frequently, high-dose treatments can severely damage or destroy the patients bone marrow. Without healthy bone marrow, the patient is no longer able to make the blood cells needed to carry oxygen, fight infection, and prevent bleeding. BMT and PBSCT replace stem cells destroyed by treatment. The healthy, transplanted stem cells can restore the bone marrows ability to produce the blood cells the patient needs.

In some types of leukemia, the graft-versus-tumor (GVT) effect that occurs after allogeneic BMT and PBSCT is crucial to the effectiveness of the treatment. GVT occurs when white blood cells from the donor (the graft) identify the cancer cells that remain in the patients body after the chemotherapy and/or radiation therapy (the tumor) as foreign and attack them. (A potential complication of allogeneic transplants called graft-versus-host disease is discussed in Questions 5 and 14.)

What types of cancer are treated with BMT and PBSCT?

BMT and PBSCT are most commonly used in the treatment of leukemia and lymphoma. They are most effective when the leukemia or lymphoma is in remission (the signs and symptoms of cancer have disappeared). BMT and PBSCT are also used to treat other cancers such as neuroblastoma (cancer that arises in immature nerve cells and affects mostly infants and children) and multiple myeloma. Researchers are evaluating BMT and PBSCT in clinical trials (research studies) for the treatment of various types of cancer.

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Bone Marrow Transplantation and Peripheral Blood Stem Cell ...

Irvine Stem Cell Treatment Center

By Stem Cell Medical Center

The Advancement of Stem Cell Technology

Welcome to the Irvine Stem Cell Treatment Center, and affiliate of the California Stem Cell Treatment Center and the Cell Surgical Network of Beverly Hills and Rancho Mirage, California, USA.

Our affiliated Treatment Centers utilize cutting edge advanced techniques and innovative technology to improve the health and well being of our patients.

At the Irvine Stem Cell Treatment Center, we engage in the investigational use of Adipose Derived Stem Cells (ADSCs) for clinical research and deployment through which patients who are suffering from diseases that may have limited treatment options have an opportunity to respond to stem cell based regenerative treatment and further advance the state of medicine, knowledge, and treatment options for all patients.

Our expertise involves a deep commitment and long-term understanding, knowledge, experience and expertise in clinical research and the advancement of regenerative medicine. Our staff and Physicians at the Irvine Stem Cell Treatment Center have been trained by the Founders and world renown specialists of the California Stem Cell Treatment Center, who have been nationally recognized for working with autologous (your own) adipose derived stem cells providing investigational therapy to patients with various inflammatory and/or degenerative conditions.

Our Centers utilize a fat transfer technology to isolate and implant the patients own stem cells from a small quantity of fat harvested by liposuction on the same day. Using technology developed in South Korea, our Centers have developed an in-office procedure to isolate this cellular medium called the Stromal Vascular Fraction (SVF) which is rich in Stem Cells. Our Founders have also worked in conjunction with a number of international organizations and physicians of great expertise to help develop our protocols for procedures. In 2012, the Cell Surgical Network (CSN) was formed to provide the same high level quality controlled investigational therapy both nationally and internationally.

Our Protocols are approved by an IRB (Institutional Review Board) approved protocol, and accordingly we are able to safely provide adipose (fat)-derived stem cell procedures on an investigational basis to our patients. Modeled after the California Stem Cell Treatment Center, weve formed a multidisciplinary team to evaluate patients with a variety of conditions which are known to often be responsive to Stem Cell therapy.

All affiliate members of the California Stem Cell Treatment Center and the Cell Surgical Network, including our Irvine Stem Cell Treatment Center, contribute to the California Centers IRB approved investigation data. In this manner, we are continuously updating, researching, and learning more on how to help patients and advance the state of the art of regenerative medicine.

All patients who are interested in our investigational treatment protocols will be evaluated by our physicians specially trained in our adipose-derived stem cell procedures and given an honest opinion as to the potential benefits and risks of stem cell therapy for their presenting condition.

The Irvine Stem Cell Treatment Center is proud to be part of the only Institutional Review Board (IRB)-based stem cell treatment network in the United States that utilizes fat-transfer surgical technology. We have an array of ongoing IRB-approved protocols, and we provide care for patients with a wide variety of disorders that may be treated with adult stem cell-based regenerative therapy. At the Irvine Stem Cell Treatment Center we exploit anti-inflammatory, immuno-modulatory and regenerative properties of adult stem cells to mitigate inflammatory and degenerative diseases.

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Irvine Stem Cell Treatment Center

Cardiac Stem Cell Therapy How It Works Current Controversies …

By Stem Cell Doctors

What is a hormone? A hormone is one of the many chemical messengers of the body. Hormones are comprised of proteins that form peptide chains and direct the functions of our body. One of the most vital of these chemical messengers is Human Growth Hormone.

We here at Bio-Identical Hormone Replacement Therapy MD, the Conscious Evolution Medical Institute, want to do everything we can to help you make an informed decision about Hormone Replacement Therapy. Therefore, we have compiled this information about the history, benefits, pros, and cons of growth hormone imbalance treatment.

GH (Growth Hormone), also known as STH (somatotropin) is a hormonal protein that stirs growth and also the reproduction of cells in people and many animals. Its a lone chain of one hundred ninety one amino type acids that makes up a hormone of the polypeptide variety. It is manufactured, secreted, and stored by somatotrophic cells inside the lateral wings of the anterior of the pituitary gland.

The following information about the physiology of Growth Hormone also reviews briefly diseases caused by a deficiency of Human Growth Hormone as well as excessive Growth Hormone(gigantism and pituitary acromegaly). It also discusses treatment that features Human Growth Hormone. To learn more about a commonly used growth hormone that is often given to cattle, look up bovine somatotropin.

Terms

Recombinant HGH Human Growth Hormone is called somatotropin as well (In Britain: Somatotrophin)

HGH is an acronym for Human Growth Hormone. This hormone, HGH, is released from or extracted in a measured fashion from the pituitary gland of human beings.

In the 1980s, Human Growth Hormone of biosynthetic form replaced Human Growth Hormone that was derived from the pituitary in bio hormone replacement therapy used in the United States and other locations. Previously, Human Growth Hormone was gathered from processed pituitary glands. derived Biosynthetic HGH, also referred to as Recombinant Human Growth Hormone, is known as Somatropin and the abbreviation rhGH is used.

From the middle of the 1980s, the HGH abbreviation started to carry connotations that were paradoxical. It now quite rarely is used in reference to Human Growth Hormone for the purposes that are indicated.

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Cardiac Stem Cell Therapy How It Works Current Controversies ...

Stem Cell Transplantations: Cancer Treatment | MD Anderson …

By Stem Cell Clinic

MDAnderson's Stem Cell Transplantation and Cellular Therapy Center is one of the largest facilities in the world for stem cell transplants, performing more than 865 procedures for adults and children each year, more than any other center in the nation.

We treat a wide variety of cancers, hematologic diseases and autoimmune disorders, including:

Our center is recognized by the National Marrow Donor Program (NMDP) as a specialized center for matched unrelated donor stem cell transplants, and maintains an advanced cell processing laboratory dedicated to preparing safe and effective tissues for transplantation. The apheresis and stem cell collection unit performs over 1,000 blood stem cell collections annually.

In addition to inpatient and outpatient services, the Stem Cell Transplantation and Cellular therapy center has a clinic that helps monitor and manage complications of graft versus host disease.

Patients can be referred to the Stem Cell Transplantation & Cellular Therapy Center for cancer treatment.

Please complete the Patient Self-Referral form. You will be contacted by a Referral Specialist to collect the additional information required for confirming your appointment.

Please complete the Physician Referral form. A Referral Specialist will contact your office for additional information and then contact your patient to confirm the appointment.

Take advantage of our online services, including myMDAnderson, the personalized site that helps you manage your cancer treatment:

Go to myMDAnderson

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Stem Cell Transplantations: Cancer Treatment | MD Anderson ...

Regenerative medicine – Wikipedia, the free encyclopedia

By Uncategorized

Regenerative medicine is the "process of replacing or regenerating human cells, tissues or organs to restore or establish normal function".[1] This field holds the promise of regenerating damaged tissues and organs in the body by replacing damaged tissue and/or by stimulating the body's own repair mechanisms to heal previously irreparable tissues or organs.

Regenerative medicine also includes the possibility of growing tissues and organs in the laboratory and safely implant them when the body cannot heal itself This can potentially solves the problem of the shortage of organs available for donation, and the problem of organ transplant rejection if the organ's cells are derived from the patient's own tissue or cells.[2][3][4]

Widely attributed to having first been coined by William Haseltine (founder of Human Genome Sciences),[5] the term "Regenerative Medicine" was first found in a 1992 article on hospital administration by Leland Kaiser. Kaisers paper closes with a series of short paragraphs on future technologies that will impact hospitals. One such paragraph had Regenerative Medicine as a bold print title and went on to state, A new branch of medicine will develop that attempts to change the course of chronic disease and in many instances will regenerate tired and failing organ systems.[6][7]

Regenerative medicine refers to a group of biomedical approaches to clinical therapies that may involve the use of stem cells.[8] Examples include the injection of stem cells or progenitor cells (cell therapies); the induction of regeneration by biologically active molecules administered alone or as a secretion by infused cells (immunomodulation therapy); and transplantation of in vitro grown organs and tissues (Tissue engineering).[9][10]

A form of regenerative medicine that recently made it into clinical practice, is the use of heparan sulfate analogues on (chronic) wound healing. Heparan sulfate analogues replace degraded heparan sulfate at the wound site. They assist the damaged tissue to heal itself by repositioning growth factors and cytokines back into the damaged extracellular matrix.[11][12][13] For example, in abdominal wall reconstruction (like inguinal hernia repair), biologic meshes are being used with some success.

At the Wake Forest Institute for Regenerative Medicine, in North Carolina, Dr. Anthony Atala and his colleagues have successfully extracted muscle and bladder cells from several patients' bodies, cultivated these cells in petri dishes, and then layered the cells in three-dimensional molds that resembled the shapes of the bladders. Within weeks, the cells in the molds began functioning as regular bladders which were then implanted back into the patients' bodies.[14] The team is currently[when?] working on re-growing over 22 other different organs including the liver, heart, kidneys and testicles.[15]

From 1995 to 1998 Michael D. West, PhD, organized and managed the research between Geron Corporation and its academic collaborators James Thomson at the University of Wisconsin-Madison and John Gearhart of Johns Hopkins University that led to the first isolation of human embryonic stem and human embryonic germ cells.[16]

Dr. Stephen Badylak, a Research Professor in the Department of Surgery and director of Tissue Engineering at the McGowan Institute for Regenerative Medicine at the University of Pittsburgh, developed a process for scraping cells from the lining of a pig's bladder, decellularizing (removing cells to leave a clean extracellular structure) the tissue and then drying it to become a sheet or a powder. This cellular matrix powder was used to regrow the finger of Lee Spievak, who had severed half an inch of his finger after getting it caught in a propeller of a model plane.[17][18][19][dubious discuss] As of 2011, this new technology is being employed by the military to U.S. war veterans in Texas, as well as to some civilian patients. Nicknamed "pixie-dust," the powdered extracellular matrix is being used success to regenerate tissue lost and damaged due to traumatic injuries.

In June 2008, at the Hospital Clnic de Barcelona, Professor Paolo Macchiarini and his team, of the University of Barcelona, performed the first tissue engineered trachea (wind pipe) transplantation. Adult stem cells were extracted from the patient's bone marrow, grown into a large population, and matured into cartilage cells, or chondrocytes, using an adaptive method originally devised for treating osteoarthritis. The team then seeded the newly grown chondrocytes, as well as epithileal cells, into a decellularised (free of donor cells) tracheal segment that was donated from a 51 year old transplant donor who had died of cerebral hemorrhage. After four days of seeding, the graft was used to replace the patient's left main bronchus. After one month, a biopsy elicited local bleeding, indicating that the blood vessels had already grown back successfully.[20][21]

In 2009 the SENS Foundation was launched, with its stated aim as "the application of regenerative medicine defined to include the repair of living cells and extracellular material in situ to the diseases and disabilities of ageing." [22]

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Regenerative medicine - Wikipedia, the free encyclopedia

Stem Cell Therapy Research Dr. Steenblock Umbilical Cord Stem …

By Stem Cell Treatment

We stand at the threshold of a new and exciting medicine of Regeneration where transplants of stem cells can potentially restore function to injured, diseased and debilitated tissues and organs.

Embryonic-like stem cells found in umbilical cord blood!

Umbilical cord blood was first used for blood and immune system disorders about 18 years ago.For the past several years, new possibilities for their use in a wider variety of health conditions, genetic disorders and anti-aging treatmentshave beengaining support with various multipotent stem cells and progenitor cells being discovered in the cord blood. In fact, embryonic-like stem cells have actually been found in umbilical cord blood and are beingused in clinical researchnow for various neurological disorders outside the United States. Dr. Colin McGuckin and associates from the U.K. have published preliminary findings on these embryonic-like stem cells.

Whether the health challenge is Alzheimer's Disease, Stroke, Traumatic Brain Injury, Cerebral Palsy, Spinal Cord Injuries, Parkinson's Disease, Heart Disease, Diabetes, Blindness or Immune Deficiencies, the results of preliminary animal and human studies have been very promising.

With each passing year, the field is growing exponentially and we invite you to find out more about this exciting new field of regenerative medicine.

This website is sponsored by the Steenblock Research Institute, a 501(c)(3)California non-profit corporation dedicated to educating the public about safe and effective alternatives for difficult medical cases. Contribute to our on-going projects in researching medical alternatives here.

UMBILICAL CORD STEM CELL THERAPY by David Steenblock, D.O. and Anthony Payne, Ph.D.

This book presents case studies of umbilical cord stem cells being used to treat patients with cancer, cerebral palsy, stroke, ALS, MS and other challenging medical conditions.

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Stem Cell Therapy Research Dr. Steenblock Umbilical Cord Stem ...

Adult Stem Cells – Therapies and Treatments –

By Stem Cell Treatment

Life-Saving Stem Cells - Discover, Learn, ShareNearly everyone inside and outside of the medical and scientific community agrees that stem cell research represents one of the most exciting and promising frontiers for treating people with a myriad of diseases and conditions. Stem cell research and treatments represent perhaps mankind's greatest opportunity to fulfill that ancient call to "heal the sick," relieve suffering and improve the quality of life for untold millions of people.

This website provides scientific facts and concise information for those of us who are not scientists, researchers or medical professionals. You will learn answers toquestions like ..."Who is benefitting from stem cell research and therapies today?" and "What types of stem cells are working?" In addition, basic questions such as"What is a stem cell?""Why do we need stem cell research?" are answered.

The video patient profiles featured on this site emphasize ADULT stem cell advances with the goal of informing and the hope of inspiring you to take action. These real-life stories represent a small sampling of people and the many diseases and conditions now being helped by adult stem cells naturally found in the human body. Stem Cell Research Facts illustrates how current adult treatments and therapies directly impact the lives of patients and their families today - as opposed to debating themerits of other types of stem cell research.

We invite you to discover, learn and share the incredible possibilites of stem cell research. We welcome your feedback and encourage you to return for the latest developments in the world of stem cell research. Thank you!

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Adult Stem Cells - Therapies and Treatments -

Health Link Medical Center – Stem Cell Therapy California …

By Stem Cell Medical Center

Regenexx PL-Disc: Next Generation Treatment for Disc Problems

Helping individuals avoid back surgery and the serious side effects of epidural steroids. Learn More >>

The Nations Most Advanced Stem Cell and Platelet Procedures Now Available in the San Diego and San Francisco Areas.

Learn More >>

Health Link Medical Centers Mill Valley offices not only serve San Francisco, Marin County and northern California, but we regularly see Regenexx patients from the entire western and north-western regions. Contact us at 800-281-3757 today.

Come see us. Were experts in the diagnosis and treatment of common injuries and joint pain.

Health Link Medical Centers new offices offer patients a more convenient location with better parking and room for future expansion. Learn More

The doctors at Health Link Medical Center are specialists in orthopedic stem cell therapy and regenerative medicine. We currently offer two convenient locations in North San Diego County and Mill Valley / San Francisco California. Health Link Medical Center is proud to bring Regenexx Stem Cell and Regenerative Medicine Procedures to the west coast. The Regenexx Family of Advanced Regenerative Medicine Procedures offer non-surgical options for individuals experiencing pain resulting from common injuries and degenerative conditions. Regenexx procedures offer a viable alternative to surgery, and patients experience little down time and avoid the long and often painful rehab period that typically follows surgery.

Health Link Medical Center has focused on cutting edge regenerative and physical medicine since its founding in early 2008, boasting a proud record of positive outcomes for very difficult degenerative conditions of the spine and other joints. We understand what it means to seek a good physical quality of life and our specialists are focused on making positive differences in the lives of our patients through innovative stem cell therapy and regenerative medicine treatments.

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Health Link Medical Center - Stem Cell Therapy California ...

Dr. Raj on Late Night Health on Stem Cell Therapy – Video

By Stem Cell Doctors

What is a hormone? A hormone is one of the many chemical messengers of the body. Hormones are comprised of proteins that form peptide chains and direct the functions of our body. One of the most vital of these chemical messengers is Human Growth Hormone.

We here at Bio-Identical Hormone Replacement Therapy MD, the Conscious Evolution Medical Institute, want to do everything we can to help you make an informed decision about Hormone Replacement Therapy. Therefore, we have compiled this information about the history, benefits, pros, and cons of growth hormone imbalance treatment.

GH (Growth Hormone), also known as STH (somatotropin) is a hormonal protein that stirs growth and also the reproduction of cells in people and many animals. Its a lone chain of one hundred ninety one amino type acids that makes up a hormone of the polypeptide variety. It is manufactured, secreted, and stored by somatotrophic cells inside the lateral wings of the anterior of the pituitary gland.

The following information about the physiology of Growth Hormone also reviews briefly diseases caused by a deficiency of Human Growth Hormone as well as excessive Growth Hormone(gigantism and pituitary acromegaly). It also discusses treatment that features Human Growth Hormone. To learn more about a commonly used growth hormone that is often given to cattle, look up bovine somatotropin.

Terms

Recombinant HGH Human Growth Hormone is called somatotropin as well (In Britain: Somatotrophin)

HGH is an acronym for Human Growth Hormone. This hormone, HGH, is released from or extracted in a measured fashion from the pituitary gland of human beings.

In the 1980s, Human Growth Hormone of biosynthetic form replaced Human Growth Hormone that was derived from the pituitary in bio hormone replacement therapy used in the United States and other locations. Previously, Human Growth Hormone was gathered from processed pituitary glands. derived Biosynthetic HGH, also referred to as Recombinant Human Growth Hormone, is known as Somatropin and the abbreviation rhGH is used.

From the middle of the 1980s, the HGH abbreviation started to carry connotations that were paradoxical. It now quite rarely is used in reference to Human Growth Hormone for the purposes that are indicated.

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Dr. Raj on Late Night Health on Stem Cell Therapy – Video

HIV & AIDS Information :: Stem cell transplant has cured HIV …

By Stem Cell Doctors

The 'Berlin patient' is an HIV-positive man who developed acute myeloid leukaemia, received successful treatment and subsequently experienced a relapse in 2007 that required a transplant of stem cells.

Doctors chose stem cells from an individual who had an unusual genetic profile: a mutation inherited from both parents that resulted in CD4 cells that lacked the CCR5 receptor. This mutation, called CCR5 delta 32 homozygosity, is present in less than 1% of Caucasians in northern and western Europe, and is associated with a reduced risk of becoming infected with HIV.

This is because all new infecting viruses need to use the CCR5 receptor on CD4 cells when infecting an immune system cell of the CD4 type.

Later in the course of HIV infection another type of virus emerges that can use the CXCR4 receptor instead.

Before the stem cell transplant the patient received chemotherapy treatment that destroyed most immune cells and total body irradiation, and also received immunosuppressive drugs to prevent rejection of the stem cells.

Antiretroviral therapy was halted on the day of the transplant, and the patient had to receive a second stem cell transplant 13 days after the first one, due to a further relapse of leukaemia.

The patient continued to receive immunosuppressive treatment to prevent rejection for 38 months, and at 5, 24 and 29 months post-transplant colon biopsies were taken to investigate possible graft-versus-host disease in the intestine. At each investigation additional samples were taken to check for signs of HIV infection in the abundant immune cells of the gut wall.

During the 38 month follow-up period the donor CD4 cells repopulated the mucosal immune system of the gut, to such an extent that the frequency of CD4 cells was almost twice as high as in HIV-negative healthy controls, and this phenomenon was also seen in a control group of ten HIV-negative individuals who received stem cell transfers.

The repopulation of CD4 cells was accompanied by the complete disappearance of host CD4 cells, and after two years the patient had the CD4 count of a healthy adult of the same age.

One of the challenges for any approach to curing HIV infection is long-lived immune system cells, which need to be cleared before a patient can be cured. In the case of the Berlin patient CCR5-bearing macrophages could not be detected after 38 months, suggesting that chemotherapy had destroyed these longer-lived cells, and that they had also been replaced by donor cells.

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HIV & AIDS Information :: Stem cell transplant has cured HIV ...

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