Stem Cell Clinic

ADVICE FOR KRIS AQUINO | Get stem cell treatment for Josh in PH

By Stem Cell Treatment

By: Jet Villa, InterAksyon.com April 24, 2013 4:10 PM

InterAksyon.com The online news portal of TV5

MANILA, Philippines The most advanced stem cell technologies and competent experts in the field are available in the country, according to two medical groups that advised actress-host Kris Aquino on Wednesday to consider having her son Joshua treated locally than going abroad.

They were reacting to Kris Aquinos declaration, in her morning talk show, that she planned to bring Joshua abroad for stem cell treatment.

Dr. Leo Olarte, spokesman of the Philippine Society for Stem Cell Medicine (PSSCM), said Filipinos no longer need to seek stem cell treatment outside the country. We have the ethical, moral, safe and effective stem cell or regenerative medicine technology available in the country today, said Olarte, also the president of the Philippine Medical Association.

The Philippines is abreast with the latest trends in stem cell technology, described as the future of medicine.Olarte said, We not only have internationally accepted stem cell technologies here but the competent medical doctors and experts as well to perform the procedure for our patients.

Their group, said Olarte, was willing to help Kris get the correct information to guide her in making the right decision for her beloved son Josh.

Aquino had revealed in her talk show that she was considering bringing Joshua, who has autism, to stem cell facilities in Europe, followed by Singapore, and then the Medical City in Pasig City.

Similarly situated friendsthose with special childrenhad reported big improvements in their kids after undergoing the procedure, Kris said.

The PSSCM has been working closely, said Olarte, with the Department of Health and the Professional Regulation Commissions Board of Medicine in the mission of having stem cell therapy highly regulated by the government to protect patients from unscrupulous practices.

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ADVICE FOR KRIS AQUINO | Get stem cell treatment for Josh in PH

Stem Cell Institute Public Seminar on Adult Stem Cell Therapy in Miami, Florida May 11th, 2013

By Stem Cell Treatment

The Stem Cell Institute, located in Panama City, Panama, will present an informational umbilical cord stem cell therapy seminar on Saturday, May 11, 2013 in Miami, Florida at the Conrad Hotel from 1:00 pm to 4:00 pm.

Miami, Florida (PRWEB) April 24, 2013

Speakers and topics include:

"Umbilical cord stem cells: regeneration, repair, inflammation and autoimmunity" - Neil Riordan, PhD

Dr. Riordan is the Founder of the Stem Cell Institute and Medistem Panama Inc.

Dr. Paz is the Medical Director at the Stem Cell Institute. Dr. Paz practiced internal medicine in the United States for over a decade before joining the Stem Cell Institute in Panama.

Dr. Lowe is a psychiatrist at Amen Clinics in New York City.

Raymond Cralle is a physical therapist at Cralle Physical Therapy in Delray Beach, Florida.

After the talks, our speakers and stem cell therapy patients will be on hand to share their personal experiences and answer questions.

Admission is free but space is limited and registration is required. For venue information and to register and reserve your tickets today, please visit: http://scimiamiseminar.eventbrite.com/ or call Cindy Cunningham, Patient Events Coordinator, at 1 (800) 980-7836.

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Stem Cell Institute Public Seminar on Adult Stem Cell Therapy in Miami, Florida May 11th, 2013

Kris told: Stem cell treatment available in PH

By Stem Cell Treatment

MANILA, Philippines There is no need for actress-TV host Kris Aquino to seek stem cell therapy treatment abroad for her son Joshua.

Dr. Leo O. Olarte, president of the Philippine Medical Association (PMA) and spokesman of the Philippine Society for Stem Cell Medicine (PSSCM), said stem cell treatment experts in the Philippines are competent enough to help Aquino's 17-year-old son. We have the ethical, moral, safe and effective stem cell or regenerative medicine technology available in the country today," Olarte said in a statement released Wednesday. Olarte added that the Philippines does not only have internationally accepted stem cell technologies but also the competent medical doctors and experts.

PSSCM has been closely working with the Department of Health (DOH) and currently in consultation with the Professional Regulatory Commission (PRC) Board of Medicine in our desire that the practice of stem cell therapy be highly regulated by our government to protect our patients from unscrupulous practices," he said.

Olarte said they are willing to help Aquino if she considers getting the treatment for her son done in the Philippines.

If consulted we are very willing to help in any way Ms. Kris Aquino most especially in making available to her the correct information to guide her in making the right decision for her beloved son Josh, he said.

On her talk show Kris TV, Aquino said she wants her son Josh, who has Attention Deficit Hyperactivity Disorder (ADHD), to undergo stem cell therapy after getting advice from some of her friends. "Meron akong mga friends na 'yung mga anak nila underwent stem cell therapy. And 'yung condition nila is just like Josh's and they're special children. Sobrang laki kasi yung naging improvement," said Aquino.

Safety first

Dr. Olarte, however, warned patient about the dangers of xenogenic or allogenic stem cell sources which use stem cells from animals, plants, and even from other human beings.

Reports of such cases done in Germany, Hong Kong, Singapore, and other countries resulting to death due to severe complications have reached Olarte's office.

PSSCM is pushing only for autologous stem cell therapy which means that the source of the stem cells must come only from the patients own body namely from the patients own bone marrow, blood and adipose tissues (fat) because this is the safest and proven procedure that is available worldwide today, explained Olarte.

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Kris told: Stem cell treatment available in PH

Human Stem Cells Injected In Mice Restore Memory, Learning …

By Stell Cell Research

April 22, 2013

redOrbit Staff & Wire Reports Your Universe Online

Researchers at the University of Wisconsin-Madison have successfully transformed human embryonic stem cells into nerve cells that helped mice regain their memory and the ability to learn.

Senior author Su-Chun Zhang, a professor of neuroscience and neurology at the university, said that he and his colleagues have for the first time demonstrated that human stem cells can implant themselves in the brain and heal neurological defects.

Once they were inserted into the brain of the rodents, the implanted stem cells formed two common but essential types of neurons. Those neurons which Zhang said are involved with many different types of human behavior, emotions, learning, memory, and psychiatric issues communicate with the chemicals GABA or acetylcholine.

The embryonic stem cells used in the study were cultured in a laboratory using chemicals known to promote development into nerve cells. Zhang has worked on similar projects for the past 15 years, according to the university, and has helped pioneer research in the field.

As for the mice, they were said to be a special type which did not reject transplants from other species. An area of their brains responsible for memory and learning, known as the medial septum, were then intentionally damaged. The medial septum connects to the GABA and cholinergic neurons, Zhang said.

This circuitry is fundamental to our ability to learn and remember, he added.

The human cells were transplanted into the hippocampus, a key memory center located at the opposite end of those memory circuits. Following the successful implementation of the stem cells, the mice reportedly scored significantly better on common tests in both memory and learning.

After the transferred cells were implanted, in response to chemical directions from the brain, they started to specialize and connect to the appropriate cells in the hippocampus, the university explained in a statement. The process is akin to removing a section of telephone cable If you can find the correct route, you could wire the replacement from either end.

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Human Stem Cells Injected In Mice Restore Memory, Learning ...

Scientist identifies protein molecule used to … – Stem Cell Cafe

By Stell Cell Research

Apr. 22, 2013 Understanding exactly how stem cells form into specific organs and tissues is the holy grail of regenerative medicine. Now a UC Santa Barbara researcher has added to that body of knowledge by determining how stem cells produce different types of daughter cells in Drosophila (fruit flies). T

he findings appear today in the Proceedings of the National Academy of Sciences.

Denise Montell, Duggan Professor of Molecular, Cellular and Developmental Biology at UCSB, and colleagues studied the ovaries of fruit flies in order to see stem cells in their natural environment. Because these organisms are excellent models for understanding stem cell biology, researchers were able to shed light on the earliest stages of follicle cell differentiation, a previously poorly understood area of developmental biology. It is clear that the fundamental principles that control cell behavior in simple animals are conserved and control the behavior of our cells as well, she said. There is so much we can learn by studying simple organisms.

Using a nuclear protein expressed in follicle stem cells (FSCs), the researchers found that castor, which plays an important role in specifying which types of brain cells are produced during embryonic development, also helps maintain FSCs throughout the life of the animal. Having identified this important protein molecule in fruit flies, we can test whether the human version of the protein is important for stem cells and their daughters as well, said Montell. The more we know about the molecules that govern stem cell behavior, the closer we will get to controlling these cells.

Her research team placed the evolutionarily conserved castor (Cas) gene, which encodes a zinc finger protein, in a genetic circuit with two other evolutionarily conserved genes, hedgehog (Hh) and eyes absent (Eya), to determine the fates of specific cell progeny (daughters). Whats more, they identified Cas as a critical, tissue-specific target of Hh signaling, which not only plays a key role in maintaining follicle stem cells but also assists in the diversification of their progeny.

The study also shows that complementary patterns of Cas and Eya reveal the gradual differentiation of polar and stalk precursor cells at the earliest stages of their development. In addition, it provides a marker for cell fates and insight into the molecular and cellular mechanisms by which FSC progeny diverge into distinct fates.

Follicle cells undergo a binary choice during early differentiation. Those that turn into specialized cells found at the poles of egg chambers go on to make two cell types: polar and stalk. The three genes, Cas, Eya and Hh, work in various combinations, sometimes repressively, to determine which types of cells are formed. Cas is required for polar and stalk cell fate specification, while Eya is a negative regulator of these cells fate. Hh is necessary for Cas to be expressed, and Hh signaling is essential to repress Eya.

If you just had one of these markers, it was hard to tell whats going on, explained Montell. All the cells looked the same and you had no idea when or how the process occurred. But now we can actually see how the cells acquire different identities.

Hh also plays many roles in embryonic development, adult homeostasis, birth defects, and cancer. Hh antagonists are currently in clinical trials for the treatment of several types of cancer. However, Hh signaling is important in so many different cell types and tissues that systemic delivery of such inhibitors may cause serious side effects. Therefore identifying the essential, tissue-specific effectors of Hh has the potential to lead to the identification of more specific therapeutic targets.

Someday, targeted inhibition of Hh signaling may be effective in the treatment and prevention of many types of human cancers.

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Scientist identifies protein molecule used to ... - Stem Cell Cafe

Kris wants Josh to undergo stem cell therapy

By Uncategorized

Kris Aquino will try anything -- even the new stem cell therapy technology in Singapore to help eldest son Josh cope with his Attention Deficit Hyperactivity Disorder (ADHD) condition. Read related story: Kris In Search For Joshuas House

"Meron akong mga friends na yung mga anak nila underwent stem cell therapy. And yung condition nila is just like Josh's and they're special children. Sobrang laki kasi yung naging improvement," Kris said on "KrisTV" on Tuesday, April 23.

Physical exam

Kris said Josh will have a physical exam on April 24 to check if he is fit to undergo stem cell therapy.

"Hindi mo naman matatanggi sa akin na anything to improve my son kasi ngayon na-achieve namin yung physical improvement. Kasi di ba naka-lose nga siya ng 120 pounds? So ngayon we have the means naman, bakit hindi ko susubukan kung makakatulong ito for him to become more verbal, yung cognitive skills lalong ma-improve?"

She added, "Meron raw sa Singapore na kinukuha rin sa nanay, yung stem cell. Manggagaling raw sa fat ng nanay. Kasi yung fat ng nanay ang highly-concentrated ang stem cell. So kukunin either sa tiyan or hita ng nanay then itatransfer sa anak."

ABS-CBN announced that Kris will take a leave from work in June to attend to her sons' needs, including bringing Josh abroad "to advance his developmental progress."

Also read: Kris not resigning, will 'take a leave instead'

Adult Josh

"Iyan ita-try nating lahat kasi it's so hard to believe that this June 4, Josh is turning 18. May adult na akong anak. Ita-try natin ito. Part of the reason why I'm taking a leave is because I want Josh to have these opportunities for medical improvement, lalo na andun na siya sa magandang timbang, magandang health, magandang behavior. So, ita-try namin ito para tuloy-tuloy ang progress ng anak ko," she said.

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Kris wants Josh to undergo stem cell therapy

A KEY TO REGENERATIVE MEDICINE: Discovery of a new adult stem cell with special properties – Video

By Stem Cell Treatment


A KEY TO REGENERATIVE MEDICINE: Discovery of a new adult stem cell with special properties
Learn about the exciting discovery that could revolutionize regenerative medicine by providing a source to produce organs derived from a patient #39;s own stem c...

By: YourekaScience

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A KEY TO REGENERATIVE MEDICINE: Discovery of a new adult stem cell with special properties - Video

ACT Initiates Higher-Dosage Patient Treatment in European Clinical Trial for Macular Degeneration

By Stem Cell Treatment

MARLBOROUGH, Mass.--(BUSINESS WIRE)--

Advanced Cell Technology, Inc. (ACT; OTCBB: ACTC), a leader in the field of regenerative medicine, today announced treatment of the first patient in the third dosage cohort, and seventh patient overall, in its European Phase I clinical trial for Stargardts macular dystrophy (SMD) using retinal pigment epithelial (RPE) cells derived from human embryonic stem cells (hESCs). The patient was injected with 150,000 hESC-derived RPE cells, as compared with the 100,000-cell dose used in patients of the second cohort. The surgery was performed on Friday, April 19, without any complications, and the patient is recovering uneventfully.

Europe represents a huge potential market for us, the worlds largest after the U.S., so we are particularly pleased to now be past the halfway point in all three of our clinical trials on both continents, commented Gary Rabin, chairman and CEO of ACT. SMD affects as many as 100,000 patients in the U.S. and Europe. Moreover, as previously announced, the European Medicines Agency's (EMA) Committee for Orphan Medicinal Products (COMP) officially granted our hESC-derived RPE cells orphan medicinal product designation for the treatment of SMD. We expect this will provide a number of benefits once our SMD treatment has made the transition from the clinic to the bedside, including reduced fees and protection from competition.

The Phase 1/2 trial is designed to determine the safety and tolerability of hESC-derived RPE cells following sub-retinal transplantation in patients with SMD at 12 months, the studys primary endpoint. It will involve a total of 12 patients, with cohorts of three patients each in an ascending dosage format.

We are pleased to have now moved into the second-half of all our clinical trials for macular degeneration, said Robert Lanza, M.D., chief scientific officer. We are eagerly anticipating advancing toward the final cohort in all three trials.

About Stargardts Disease

Stargardts disease or Stargardts Macular Dystrophy is a genetic disease that causes progressive vision loss, usually starting in children between 10 to 20 years of age. Eventually, blindness results from photoreceptor loss associated with degeneration in the pigmented layer of the retina, called the retinal pigment epithelium, which is the site of damage that the company believes the hESC-derived RPE may be able to target for repair after administration.

About Advanced Cell Technology, Inc.

Advanced Cell Technology, Inc. is a biotechnology company applying cellular technology in the field of regenerative medicine. For more information, visit http://www.advancedcell.com.

Forward-Looking Statements

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ACT Initiates Higher-Dosage Patient Treatment in European Clinical Trial for Macular Degeneration

UCLA Researchers Develop New Method for Purifying Stem Cells for Treatment

By Stem Cell Treatment

Newswise UCLA researchers led by Carla Koehler, professor of chemistry and biochemistry and Dr. Michael Teitell, professor of pathology and pediatrics, both members of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research and the Jonsson Comprehensive Cancer Center, have discovered a new agent that may be useful in strategies to remove pluripotent stem cells that fail-to-differentiate from their progeny, tissue-specific cells, potentially resulting in safer therapies for patients. The study was published online ahead of press April 15, 2013 in Developmental Cell.

Pluripotent stem cells can become any cell in the body. When stem cells are differentiated into specific daughter cells such as nerve, muscle, or bone cells, not all of the stem cells differentiate, leaving some pluripotent stem cells mixed in with the differentiated cells. Because of the pluripotent stem cells ability to become any cell type in the body, these cells can also become unintended cells such as bone in blood, or form tumors called teratomas. Therefore, identifying and removing pluripotent stem cells from the differentiated cells before using daughter cells is of utmost importance in stem cell-based therapeutics. Current methods for removing pluripotent stem cells are limited.

Studies in the model system Saccharomyces cerevisiae, simple bakers yeast, by Koehler, Teitell, and colleagues discovered a molecule called MitoBloCK-6 that inhibits assembly of the mitochondria, which are the power plants of cells. As the group moved to more complex systems, they showed that MitoBloCK-6 blocked cardiac development in the model organism, zebrafish. However, MitoBloCK-6 had no effect on differentiated cell lines that are typically cultured in the lab. I was puzzled by this result, because we thought this pathway was essential for all cells regardless of differentiation state, said Koehler.

Post-doctoral fellow Deepa Dabir meticulously tested the compound on many differentiated cell lines, but the results were still the same: The cells remained healthy. Then the team decided to test MitoBloCK-6 on human pluripotent stem cells. Post-doctoral fellow Kiyoko Setoguchi showed that the pluripotent stem cells died in the presence of MitoBloCK-6, but shortly after differentiation, the daughter cells were resistant to death.

MitoBloCK-6 caused the pluripotent stem cells to die by triggering apoptosis, a process of cell suicide. The death of pluripotent stem cells left a population of differentiated cells, thus potentially reducing the risks of teratoma and other problems that would limit their use as a regenerative medicine treatment strategy.

We discovered that pluripotent stem cell mitochondria undergo a change during differentiation into tissue-specific daughter cells, said Teitell, which could be the key to the survival of the differentiated cells when the samples are exposed to MitoBloCK-6. We are still investigating this process in mitochondria, but we now know that mitochondria have an important role in controlling pluripotent stem cell survival.

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UCLA Researchers Develop New Method for Purifying Stem Cells for Treatment

StemGenex on Exciting new Adult Stem Cell-Based Therapies for Auto-Immune Diseases

By Stem Cell Treatment

LA JOLLA, Calif., April 23, 2013 /PRNewswire/ -- Today, over 23.5 million people suffer from over eighty different types of known autoimmune diseases.Unfortunately, treatment for those suffering from non-curable autoimmune diseases has been limited to:

To view the multimedia assets associated with this release, please click http://www.prnewswire.com/news-releases/stemgenex-on-exciting-new-adult-stem-cell-based-therapies-for-auto-immune-diseases-204279071.html

With the recent emergence of regenerative medicine, doctors and medical groups around the world are developing new techniques to help treat suffering patients. New scientific and medical findings in regenerative medicine are leading to natural alternative treatments and advancements that are life altering.

The body's immune system is a complex network of special cells and organs that defends the body from germs and other foreign invaders. In order for the immune system to function properly, it needs the ability to tell the difference between what's you and what's foreign. When the immune system cannot, it attacks normal cells by mistake. The result of these misguided attacks is what is known as autoimmune disease.

Some common autoimmune diseases are:

What's exciting today is that new techniques through clinical studies are underway and they are helping unlock the code to our regenerative anatomy. For instance, studies using stem cells and gene therapy have shown great promise for ALS. This gene therapy is designed to not only target gene delivery to the brain and spinal cord, but also to genetically engineer stem cells.

Another undeniable medical breakthrough in autoimmune stem cell therapy usage occurred in Berlin Germany in 2007. Timothy Ray Brown, who was diagnosed in 1995 with HIV AIDS and Leukemia, agreed to a bone marrow transplant with the use of stem cells. Timothy received a donor's platelets and stem cells, who was immune to HIV AIDS and Leukemia. Dr. Ray Levy, a co-discoverer of the HIV epidemic and top AIDS researcher, stated the result are to be considered "A functional cure for HIV". This proclamation is due to neither HIV nor Leukemia recurring since the surgery. With the use of adult stem cells, reconstruction of damaged body tissues and recreation of the original immune system is possible.

StemGenex, a U.S. based company, is on the forefront of providing treatment access to patients suffering with all types of autoimmune diseases using adult stem cells. Intriguingly, scientific research studies suggest that adult stem cells can treat autoimmune disease effects and symptoms by reconstructing body tissue, anti-inflammatory and immune modulatory effects. StemGenex hopes to eliminate symptoms and regenerate parts of the immune system using new innovative stem cell technology.

To find out more about autoimmunestem cell treatmentscontact:

La Jolla Cove Research Center 505 Coast Boulevard South La Jolla, CA92037 858-459-STEM (7836)

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StemGenex on Exciting new Adult Stem Cell-Based Therapies for Auto-Immune Diseases

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