What Happens When Youve Gotten Filler for Years and Then Stop? – Allure

In our three-part series, The Filler Files, Allure explores our relationship with facial filler. It's still one of the most popular nonsurgical cosmetic procedures, yet more of us are looking to dissolve our filler than ever before. What does this mean for our lips, our cheeks, and our approach to injectables?

If you clicked on this headline, you likely have some relationship with hyaluronic acid fillers the injectable gels, like Juvderm and Restylane, that millions rely on to contour, plump, and smooth their features. Whether youre a diehard fan or a casual acquaintance, youve probably wondered how these sugar-based substances behave inside the body and what actually happens when we decide to quit them after years of routine touch-ups.

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In posing these questions to dermatologists and plastic surgeons, we discovered that theres a frustrating dearth of formal studies investigating hyaluronic acid fillers over the long term how and when they break down, the ways in which they change over time, and their effects on the quality of our skin and elasticity of our tissues, both during peak injectable use and long after weve sworn off the stuff. Given the paucity of hard data, much of what our experts shared is anecdotal insights informed by their decades of experience injecting and dissecting the human face. Reliable intel, nonetheless.

In the interest of not burying the lede, well start here: If youve been getting filler religiously for years, what happens when you stop will hinge on one critical factor: your average dose at each appointment. People who are getting a syringe or two every 12 months doing a little bit for specific points of volume replacement they have a much easier time than those who are receiving 5 to 10 syringes every six months, because theyre not getting to a place of overinflation and tissue distortion, saysJessica Weiser, MD, a board-certified dermatologist in New York City.

And make no mistake: Countless men and women are walking around with gluts of filler under their skin. While Dr. Weisers self-imposed limit for a single session is two or very rarely three syringes, she believes she is somewhat of an outlier among injectors. There are tons of doctors doing 10 syringes at a time, she tells us. Some of the other physicians we spoke to confirmed that they commonly encounter patients whove received 20 or even 50-plus syringes of hyaluronic acid over a one- to two-year span.

When patients come in with too much filler in their faces, it can be almost disfiguring, saysLara Devgan, MD, a board-certified plastic surgeon in New York City. The problem can be more than skin-deep, affecting both the look of the face and its functionality. Its so common that theres a term for it: filler fatigue.

Board-certified ophthalmologist and oculoplastic surgeonMitesh Kapadia, MD, describes the overfilled face as an epidemic for which a growing number are now seeking a cure namely, hyaluronic acid-melting hyaluronidase, a synthetic version of an enzyme found in the body. Youve no doubt seen celebrities, likeCourteney Cox andAmy Schumer, talking openly about being displeased with the look of their outsize cheeks or lips and having their filler dissolved with this injectable solution. Theyre hardly alone. According toThe Aesthetic Societys most recenttrend report, their members performed 57% more filler reversals in 2021 than they did the year before. Indeed, a common refrain among cosmetic providers is that theyre spending more time dissolving filler than injecting it.

Whats behind the about-face? People are realizing that theyre not looking better, but looking odd, saysElizabeth Houshmand, MD, a board-certified dermatologist in Dallas. It may be an old photo or a well-meaning family member that helps them see the error of their ways. Or a complication will clue them in, as they notice their fillermigrating or swelling. Often, though, they cant pinpoint the exact problem, Dr. Weiser says; they just know that things feel strange.

Sometimes, people break up with filler not because theyreoverfilled, per se, but because theyreover filler the look, the upkeep, the headaches and this too is a form of fatigue. The filler becomes oppressive, a burden. Especially when theyve been through bad injectables and dissolving, they just dont want to deal with it anymore theyre done, saysJonathan Cabin, MD, a board-certified facial plastic surgeon in Arlington, Virginia. In other cases, the filler has just exhausted its usefulness, no longer able to obscure insecurities in a natural-looking way and compelling once-loyal users to pursue a more powerful solution, like surgery.

So whats all this filler doing to our faces?

Overdone or poorly placed filler can muck up the mechanics of a face. The facial muscles may not move properly, and that changes not only how you look, but also how you drain, saysBen Talei, MD, a board-certified facial plastic surgeon in Beverly Hills. By way of explanation: Muscle contractions ordinarily help keep lymphatic channels flowing, but when filler envelops the muscles it restricts movement, straining our expressions and causing lymphatic fluids to stagnate and lymphatic channels to swell. All the while, the hyaluronic acid is pulling in fluid notorious water hogs, these gels intensifying bogginess and bloat. When theres such a high volume of filler going in there that the face is not draining properly, it can give the skin a sort of puffy or doughy look, adds Dr. Weiser.

Filler can also integrate with our tissues over time. In small quantities, its no big deal. It may just make certain layers of the face stronger and slicker, notes Dr. Devgan. But when copious gel piles up from repeated injections, this fusion can elicit a microcystic expansion effect, says Dr. Talei. (He describes the concept in a newstudy published in theAesthetic Surgery Journal.) As he explains, the filler penetrates as little gel particles, soaks into the various layers of the soft tissue, and [acts] like a million tiny water balloons, stretching it all out.

The soft tissue expansion reads as bulkiness, he says, sometimes with a bit of a gargoyle appearance in certain patients. In the lips, it can lend a flaccid, low-hanging look. The consequences of this distension will be more dramatic in those whove been grossly overfilled for many years.

What happens when you stop getting filler?

Patients who were filled normally shouldnt have any issues. The filler either sits around harmlessly or slowly metabolizes over time, says Dr. Talei. Dr. Weiser agrees that if judicious doses (treating every issue with as little filler as possible) were carefully injected (in tiny droplets, versus large blobs, at a safe and imperceptible depth), the bodys own hyaluronidase enzymes should gradually digest it. (In areas of little movement, like the undereyes, hyaluronic acid fillers can be rather tenacious, though, and can sometimes outstay their welcome.)

As filler fades and its effects wear off, previously treated features will shrink and flatten, creases and folds may emerge, and shadows can creep in. Whatever you were aiming to veil will be unmasked and likely accompanied by age-related changes that landed, perhaps unbeknownst to you, during your fillers tenure. Uncovering whats happened while fillers been in your face can be a lot if youre not psychologically prepared for it, cautions Dr. Cabin. On the upside, hyaluronic acid injections have beenshown to stimulate collagen production, so your skin could, consequently, be a tad thicker following years of repeated pokes.

And the post-filler expansion phenomenon the stretching and warping of tissues shouldnt really concern the low-key filler user, who is not obviously inflated. Appropriate amounts of filler do not cause this problem, Dr. Talei reassures us. It is more likely seen when excess amounts are placed [for] over a year.

Whether you let filler dissipate on its own or use dissolver to speed things along, dont expect to be left entirely filler-free. I dont think you ever get 100% back to having no filler in your face, Dr. Weiser says. A portion of it does integrate and its extremely challenging to remove every drop.

Dr. Devgan also acknowledges that trace amounts of filler can remain interwoven with our natural collagen, much like ivy thats grown into a lattice in a garden. But she stresses that this isnot something to fear. Filler disappears on a decay curve, steadily disintegrating at a consistent rate, until it becomes almost imperceptible, she explains. Even if remnants are visible on an MRI [or ultrasound], she adds, theyre not necessarily significant enough to alter a persons appearance.

If you cant see or feel your old filler, and its not acting up, the doctors we spoke with all advise against chasing it with hyaluronidase because that little bit of filler thats sticking around could be totally benign. While the gel may change character in the future, move a tiny bit, or draw in water, Dr. Talei says, in such scenarios, dissolving it is usually easy and predictable.

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Overfilled patients can also stop and/or dissolve whats in their face at any time, but it may take them longer to reach their no-filler destination and they may not love the view once they get there.

When people have been filled forever and dont remember what they looked like before, they need to know they may be opening a can of worms, saysFlora Levin, MD, a board-certified ophthalmologist and oculoplastic surgeon in Westport, Connecticut. My consent for dissolver clearly states that you may be just as unhappy, or more unhappy, after I dissolve the filler than you were prior to dissolving.

Younger patients tend to rebound fairly seamlessly, likely because they havent been filled for as many years, which means less filler in some cases and less time for expansion [of the soft tissues of the face], says Dr. Talei. Their tissues are also more resilient with a greater healing capacity.

Rarely, in extreme and prolonged cases of filler use, the face can never go back to what it was, says Dr. Talei, because the gel has damaged and, in a way, aged the tissues. He hesitates to dissolve these patients, because removing the HA (to whatever extent possible) can leave stretched tissues unsupported and desiccated, causing areas of the face to collapse and appear darker. He can usually get them to a better place: They may need to maintain some degree of HA filler while also considering surgery to address laxity, plus stem cell-rich nanofat orplatelet-rich plasma (PRP) injections to help regenerate depleted tissues.

The lips are, arguably, the most frequent victims of superfluous filler and, over time, this can carry serious consequences.

But how much filler is reasonable in the lips department? It depends on your individual starting point the undoctored size and shape of your lips. While everyones are different, a unifying characteristic is that they all have a tipping point: Upon assessing your lips, your injector should know precisely how much gel they can receive without complication.

For lips, I very seldom do more than half a cc at once, Dr. Levin says. And I dont have people come back [for touch-ups] at a specific time period. We leave it open-ended.

When lips are repeatedly filled beyond their inherent capacity, filler can seep across the vermilion border (a.k.a., the lip line) into the philtrum (the area between the lips and nose), producing a shelf-like appearance or filler mustache, says Beverly Hills board-certified plastic surgeonGary Motykie, MD. Filler migration is common here because the muscle encircling the mouth is in near-constant motion.

Beneath the skin of the philtrum is a cushy layer of fibrous tissue called the SMAS (short for superficial musculoaponeurotic system), which overlies muscle. This tissue is responsible for [providing] supple support and hydration to the lip skin, Dr. Talei explains. When an abundance of filler sits in the body of the lips and/or the SMAS for an extended period of time, these tissues can stretch and expand sometimes permanently.

If the filler is left to slowly go away [on its own], the lips may eventually return to normal, or the filler could just stay in place for years, Dr. Talei tells us. Alternatively, patients may choose to melt lip filler with hyaluronidase to take control of the process. Many people dissolve without issue and dont require any follow-up, says Dr. Talei. Occasionally, though, dissolving overfilled lips can backfire: The tissues dont snap back to their original state, he adds, and removing the filler actually may reveal the [tissue] expansion and accelerated aging that occurred while the hyaluronic acid was in place. The lips can look lax, shriveled, or asymmetric, and the skin above the vermilion may appear darker and wrinkled due to changes in the SMAS.

Ironically, the fix for this may be more lip filler a conservative dose, injected periodically, to revolumize and rehydrate the tissues. If the area above the lips looks long and droopy in the wake of overfilling, a surgical lip lift can shorten the space to youthful effect. As with other parts of the face, nanofat or PRP injections may also help repair damaged tissues.

This all sounds a little scary, we realize, and we never aim for sensationalism, so lets be 100% clear on this point: A modest amount of lip filler, even sustained over years, willnot accelerate tissue aging it just doesnt do that, Dr. Talei says. But when lips or any part of the face, for that matter have housed a ton of hyaluronic acid for a time and its inhibiting movement and stretching skin,that can speed aging tremendously.

What to do once you quit

Once youve decided to take a break from filler for however long considerdiversifying your treatment portfolio. When I see patients whove been getting only filler for 20 years and have never had any kind of radiofrequency or ultrasound or laser treatment, what I find is that their skin the luminosity, tone it just doesnt look that good, Dr. Weiser says. Try refining your complexion with a proven device or getting a subtle volume increase from collagen-stimulating Sculptra. Dont lean on hyaluronic acid exclusively. I think if you really maintain the quality of the skin and keep collagen levels boosted, the need for volumization is less, adds Dr. Weiser.

Ultimately, all procedures have limitations and respecting them can keep you looking undone through the years. When your old reliables start to fall short, you can either pause and accept your reflection as is or explore the next-level surgical realm. Happily, the choice is yours.

Check back for the third installment of our three-part series, The Filler Files.

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What Happens When Youve Gotten Filler for Years and Then Stop? - Allure

‘Brotox’ takes over TikTok: Why more men are getting cosmetic surgery – PR Week

Botox, which celebrated its20th anniversaryofFood and Drug Administrationapproval last year, is becoming increasingly popular among young men a trend dubbed as brotox.

The trend is perhaps unsurprising given Gen Z and millennials tendencies to focus on self-care,glow-ups and self-improvement.

The brotox boom is making waves among both young and old men and TikTok is home to various iterations of it.

Since brotox is having its moment in the sun, its worth looking into how popular cosmetic procedures are among men.

According to theAmerican Society of Plastic Surgeons(ASPS), cosmetic surgery and non-surgical aesthetic procedures among men rose by 29% between 2000 and 2018. In 2020 alone, more than 265,000 men got Botox procedures to target wrinkles in their face.

In particular, buttocks lifts and cheek implants saw the greatest increases among men between 2000 and 2020, rising 1,616% and 644%, respectively. Procedures including lip augmentations and laser skin resurfacing also became more popular during that time period,according to ASPS.

The trend has taken off partially due to the fact that negative connotations around Botox or cosmetic surgery for men have begun to dwindle, according toCynthia Elliott, owner and primary practitioner at cosmetic surgery clinicSkinspirations.

The stigma of vanity surrounding cosmetic procedures for men has evaporated, Elliott said in a statement. Minimally invasive treatments with little downtime and natural-looking results give men the same benefits women have enjoyed for decades enhanced self-esteem, confidence and sociability.

Indeed, a quick search on TikTok will unveil numerous men trying out Botox to treat fine lines and wrinkles giving a rundown on how the experience went for them.

Here are a few Brotox trends theyre trying out.

1. Getting rid of forehead wrinkles

Perhaps one of the most noticeable areas for wrinkles to appear is on the forehead either horizontally or within the glabellas (also known as the 11s between your eyebrows).

Before and after videosshow how a Botox treatment can minimize forehead creases, with men showcasing the differences for their followers.

2. PRP injections

In one recent video, TikTokerAndre Gadboisprovides a rundown of his recent cosmetic procedures including under-eye injections andnasolabial fold PRP injections. Gadbois explains that PRP injections involve using his own blood to extract platelet rich plasma, then injecting it back into the area of concern to stimulate healing and improved appearance.

While PRP injections have grown in popularity among cosmetic procedures, becoming a trending therapyaccording to the ASPS, the scientific evidence surrounding their efficacy for that purpose is still limited.

3. Crows feet

The peskycrows feetthat form in the corners of your eyes when you smile arent just an aesthetic concern for women.

Now, more men are seeking to minimize crows feet through Botox.

4. Lip flips

Lip flips have become increasingly popular as they offer a more subtle way of plumping your lips. The procedure involves injecting Botox into the upper lip to relax the muscles and make the lip flip upwards a little bit. Men are picking up the trend as well.

5. Eyelid lifts

Dilip Madnani, a plastic surgeon in New York with a TikTok following of more than 156,000, posted a video last year showing how his elderly father healed after getting upper eyelid surgery.

Eyelid lifts help to reduce the appearance of bags under the eyes, notesDr. Cat Plastic Surgery, in addition to removing excess skin from the upper eyelid. Not only does the removal of excess skin improve the field of vision, but it also creates a more youthful face and brighter eyes.

My dads upper eyelids surgery progress over the last 3 days. facelift, Plasticsurgery, drmadnani, FacialPlasticsurgery, Fillers, EyelidSurgery, NeckLift, fattransfer, ExpertInjector, NYC, LongIsland, blepharoplasty, eyebags, skincare, earlobe, minilift, localanesthesia, facesurgeon, #drmadnani #woodbury #centralpark beforeandafter, #newyork

6. Fillers, and more fillers

Men are realizing that its possible to get fillers for your nose rather than going through a fullrhinoplasty.

Whether your nose was damaged from an injury or you simply want to tweak how it looks, nose fillers and Botox are becoming increasingly common for men.

In one video, TikTokerxthuyledescribes how she managed to persuade her boyfriend to get filler and Botox on his nose after he got his nose broken at age 14.

Couples who get fillers together stay together, she says.

7. Botox for aging prevention

Anti-aging isnt just an area of concern for women; men want to appear youthful for as long as possible too.

More men are turning to Botox as a preventive measure to avoid forehead, frown and crows feet wrinkles. Boys get injectables too, the caption states.

This story first appeared on mmm-online.com.

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'Brotox' takes over TikTok: Why more men are getting cosmetic surgery - PR Week

Global Joint Pain Injections Market Report 2023: Growing Occurrence of Osteoarthritis Fuels the Sector – Yahoo Finance

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Dublin, April 07, 2023 (GLOBE NEWSWIRE) -- The "Global Joint Pain Injections Market Size, Share & Industry Trends Analysis Report By Injection Type, By Distribution Channel, By Joint Type Channel, By Regional Outlook and Forecast, 2022 - 2028" report has been added to ResearchAndMarkets.com's offering.

The Global Joint Pain Injections Market size is expected to reach $9.9 billion by 2028, rising at a market growth of 7.7% CAGR during the forecast period.

Key Market Players

Bioventus Inc.

Pacira BioSciences, Inc.

AbbVie, Inc.

Teva Pharmaceuticals Industries Ltd.

Pfizer, Inc.

Anika Therapeutics, Inc.

Zimmer Biomet Holdings, Inc.

Eli Lilly And Company

Ferring Holdings SA

Sanofi S.A.

Direct injections into the joints are used to treat joint pain and reduce swelling and inflammation. Geriatric patients typically have joint discomfort as a consequence of pre-existing medical conditions or illnesses.

For example, joint pain from arthritis, a common condition that primarily affects the knee, ankle, hip, shoulder, elbow, and facet joints of the spine, causes inflammation and adds to joint discomfort. The market for joint pain injections is also anticipated to grow due to the rising prevalence of rheumatoid arthritis and osteoarthritis and the rising demand for economic therapies for these diseases.

The demand for joint pain treatment solutions is increased by the aging population and the rising prevalence of obesity. To meet this rising demand, the main market participants are doing research and development operations to produce more effective treatment options, such as prolotherapy, autologous conditioned serum, platelet-rich plasma, and plasma matrix therapy.

Moreover, platelet-rich plasma (PRP) is created from the patient's blood and injected into a troublesome joint to reduce arthritis-related pain and stiffness.

Furthermore, developing such cutting-edge procedures offers major market participants chances for investment, which is expected to fuel the market's expansion throughout the forecast period. In addition, the primary reason driving the expansion of the joint pain injections market is the rise in the frequency of accident-related injuries in modern society.

Increased R&D efforts by the major market players and innovations like single injection therapy and plasma matrix therapy will present profitable opportunities for the market players to invest.

Story continues

Other factors driving the growth of the joint pain injections market include the prevalence of obesity globally, the rise in geriatric patients, and the increase in the number of arthritis cases along with joint disorders. Nonetheless, physical therapy is frequently used with injections to preserve or increase joint stability and mobility. While physical therapy alone may not be sufficient to control pain &inflammation, the pairing typically produces superior benefits.

Market Growth Factors

Growing occurrence of osteoarthritis

Osteoarthritis is one of the leading causes of disability among the elderly and a prevalent illness (OA). As the population's average age rises, the incidence of knee osteoarthritis (OA) increases. OA is the leading cause of chronic disability and the most common articular disease in the industrialized world, with knee and/or hip OA being the most common form.

As a result of population aging and the incidence of obesity and overweight in the overall population, it is anticipated that the number of people with symptomatic knee OA will increase. Joint stiffness and pain may become severe enough to make ordinary tasks difficult. Due to the rising prevalence of osteoarthritis, it is anticipated that the market for injections to treat joint pain will undergo significant growth.

Increasing global geriatric population

The World Health Organization predicts that by 2030, one in six people will be 60 or older. By this date, there will be 1.4 billion persons aged 60 or older, up from 1 billion in 2020. By 2050, the number of people worldwide aged 60 or older will have doubled. (2.1 billion). The number of persons aged 80 or older is anticipated to triple between 2020 and 2050, reaching 426 million. By 2050, two-thirds of the world's over-60 population will dwell in low- and middle-income countries.

In the elderly, back and neck pain, osteoarthritis, COPD, diabetes, depression, and dementia are all frequent diseases. As people age, they are more likely to suffer from many ailments simultaneously. In light of this, the need for joint pain injections would increase dramatically over the forecast period due to the population's aging trend.

Market Restraining Factors

Lack of knowledge regarding this treatment option

Injections for joint discomfort are unheard of by the general public. Joint soreness is treated with hyaluronic acid injections, corticosteroids, and platelet-rich plasma. It takes extensive knowledge and training to use these injections. Injections for joint pain are often given to patients by doctors and other medical personnel. Professionals are provided the equipment and instruction required to complete this. However, the market's expansion is constrained by the absence of government initiatives to support joint pain injections.

Scope of the Study

By Injection Type

By Distribution Channel

By Joint Type

For more information about this report visit https://www.researchandmarkets.com/r/qx7ca2

About ResearchAndMarkets.comResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

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‘Orgasm Shot’ Caused Excruciating Pain, San Diego Jury Told in … – Times of San Diego

On March 30, 2021, Dr. Nadine Haddad was excited to test a new service at her Fifth Avenue elective medicine spa near Balboa Park. Shed just been certified to give the O-Shot.

But before she could offer clients the clitoral and vaginal injections of their own blood PRP platelet-rich plasma she needed practice.

According to court testimony last week, Haddad asked four or five of her own employees at the B Medical Spa and Wellness Center to volunteer as models for the controversial shot which she promised improved sex drive and oh-my-God orgasms.

Jaime Herwehe, an esthetician, was one of two employees who agreed to the shot.

Two years later, testifying in downtown Superior Court, Herwehe (pronounced HER-way) described a terrifying ordeal.

With another staffer holding open her vagina by hand and the Syrian-trained physician sometimes using an iPhone to shine a light, an extremely nervous and scared Herwehe was injected with a local anesthetic that had expired three years earlier, she said.

Unaware that the liquid lidocaine offered no numbness, Haddad injected PRP into her nerve-rich clitoris, Herwehe told a jury of nine men and three women.

It was beyond excruciating, said the 32-year-old mother and former San Diego City College student. The most excruciating pain in my life.

She soon passed out on the floor a possible seizure, a witness said and has since suffered vaginal numbness.

After the botched O-Shot procedure, plaintiff was unable to have enjoyable sexual relations with her partner, her lawyers wrote. Plaintiff and her boyfriend of almost eight years and the father of her daughter broke off their longtime relationship because of the lack of intimacy and plaintiffs change in mentality towards sex.

Alleging medical malpractice, a lawsuit suit filed Sept. 15, 2021, against medical director Haddad and Haddads husband, office manager Mark Khashram, also claims that Herwehe didnt give written consent for the procedure gone awry.

And wasnt told its risks beforehand.

And according to the complaint filed by San Diego attorneys Josh Gruenberg and Pamela Vallero, Herwehe was fired May 11, 2021, for refusing to sign an O-Shot consent form 42 days after the fact.

No monetary figure is specified, but the legal team that also helped Sandra Maas win a judgment against KUSI-TV seeks a variety of penalties, including punitive damages in an amount necessary to make an example of, and to punish, defendant, and to deter future similar misconduct.

Medical battery and retaliation are also alleged, but several of the original claims were dropped.

In the formal answer to the complaint, submitted Nov. 22, 2021, the defendants said in part that Herwehe had the express knowledge of the risks and hazards set forth in the Complaint, as well as the magnitude of the risks and hazards, and thereafter knowingly and willingly assumed those risks.

The response also said:

Times of San Diego attended trial sessions Monday, Wednesday and Thursday in the fifth-floor Hall of Justice courtroom of Judge Carolyn Caietti Department 70.

Current and former B Med Spa employees testified, text messages were shown and expert testimony given.

Haddad who appeared only days before on Fox5 News and Khashram are represented by Maya Fawcett and Jack Reinholtz of Prindle, Goetz, Barnes & Reinholtz LLP, which has a University City office.

Reinholtz also is defending Haddad and Khashram in a separate lawsuit involving Jessyca De Lara Herwehes older sister who was B Med Spas manager during the same period and alleges wage violations, business fraud and intentional infliction of emotional distress.

(Trial is set for January 2024 in Judge Keri Katzs court, with Gruenberg representing De Lara.)

In Herwehes case, the spas co-owners since January 2021 have mainly attempted to throw cold water on Herwehes motives and veracity and deny she gave no prior consent. At one point, they argued a text suggested Herwehe offered a bribe to a colleague in the case.

With lawyers for both sides using sexual terms seldom heard in a court, the defense team Monday challenged expert witness James Tappan, who has 50 years of experience as an obstetrician and gynecologist.

Bottom line, youre not an expert in performing an O-Shot, Reinholtz told San Mateo-based Tappan, being paid more than $15,000 as a witness for Herwehe and appearing virtually on a video screen.

Happily, yes (not an expert), the 79-year-old Tappan replied after previously labeling the PRP shot not a recognized and accepted modality. He said it was useless to treat sexual dysfunction and that 64 risks are associated with the shot. He also said OB-GYNs dispute the existence of a G-spot, which the O-shot also promises to enhance.

Haddads certificate of completing O-Shot training with inventor Dr. Charles Runels, Tappan said, is a piece of paper not recognized by any national body. (Runels and the O-Shot are roundly mocked by other OB-GYNs.)

Ex-boyfriend Brandon Smith an SDG&E high-voltage lineman who used to live with Herwehe provided some of the most searing (and explicit) testimony.

Under questioning by Vallero, he described their sex life, which he said was great before the March 2021 procedure. But after her O-Shot, the boyfriend since 2014 said he couldnt touch her without her being uncomfortable.

She was so sensitive, she wouldnt want me to touch her anywhere, Smith said. She did a whole 180 from her previous self, showed zero patience, becoming a completely different person. Their relationship constantly turned into a fight, an argument.

Vallero asked Smith if he blamed the O-Shot for the end of their relationship.

Yeah, absolutely, he said. That whole process takes a toll and snowballed since the start of it.

Herwewe dabbed her eyes as Smith said hed made clear he never wanted to wed but planned to have a child, which they did in 2019.

Asked if hed like to get back together, Smith said: Id love to if we could work this stuff out. if we could get back to where we were.

But Herwehe didnt want to, he said.

At the next jury break, in the courtroom hallway, Smith put his arms around Herwehe.

Also on the witness stand Monday was Haddad, who said she told potential volunteers that the O-Shot improves blood supply to that area (and) overall it improves sex drive and sensitivity.

She said spa manager De Lara reported that Herwehe was fine with having the procedure and I thought I could trust her.

I asked consent and she said she signed and was ready. Haddad repeated: I was told it was signed. I hadnt seen it.

Herwehe attorney Gruenberg displayed a printout from the Medical Board of California showing that Haddads medical license had expired the previous Friday and was now delinquent.

Haddad said she had been preoccupied with this case and didnt get to it. (By late Tuesday, the license was renewed and current with an expiration date of March 31, 2025.)

Haddad acknowledged having used expired lidocaine on both her subjects, first on employee volunteer, Jessica Nieto, who didnt proceed to the actual O-Shot because it was so painful she asked me to stop.

On Wednesday, the defense called Andrea Muoz, a physicians assistant who works at Sharp Rees-Stealy but also part time at B Med Spa.

Muoz said that after discussing contraceptive options with Herwehe, she inserted an IUD in July 2021 four months after the O-Shot. She said Herwehe mentioned no pain, sensitivity or numbness.

No abnormalities in the vagina. No abnormal findings, she testified.

Muoz said she hadnt heard of Herwehes O-Shot until yesterday, having learned of it in the past 24 hours through counsel.

Herwehe, an El Cajon native who graduated from Grossmont High School in 2009 (two years after her sister), took the stand next and began describing work-related complaints.

She said everyone was promised pay raises after Haddad and Khashram took over. But it never happened. She said Khashram pressed her to expand her volunteer social media postings for the business, especially Instagram.

Soon she was doing it all the time, including her free hours, and it became exhausting.

It wasnt fun anymore, she said. And worse despite a marketing company posting we werent getting paid for it.

On the day of the O-Shot, Herwehe said colleague Evelyn Hernandez-Cardenas, who had just assisted with Nietos aborted procedure, looked very nervous, very uncomfortable.

But the doctor was still excited, telling how it was the greatest treatment ever, Herwehe testified.

Despite an excruciating lidocaine shot to the clitoris, Haddad told Herwehe: If you are past lidocaine, you should be good to go.

Haddad said shed let the area get numb and then inject PRP into the G-spot of the lying down Herwehe. Haddad used an iPhone flashlight to find the spot and said: I thought you had a kid, Herwehe told the court.

Haddad was heard saying the process was successful.

I couldnt even speak it hurt so bad, Herwehe recalled, saying co-worker Cardenas was out of breath, shaking and crying.

When helped to her feet, Herwehe felt as if she would pass out. Waking up later, as if after a long sleep, Herwehe said Haddad told her: You passed out 30 seconds, tops.

Cardenas looked like shed seen a ghost, Herwehe said. (Later that evening, the aide told Herwehe she had a two-minute seizure.)

Then Haddad noted the 2018 expiration date of the lidocaine and slapped her head, said Herwehe, licensed to give various skin and face treatments.

When Herwehe later texted Haddad about whether she needed to see a doctor, Haddad said no, suggesting she didnt have enough fluids at the time.

On her drive home, starting to feel dizzy, I was very paranoid, Herwehe said. Every injection site was red, puffy and inflamed.

When Cardenas took the stand, she recalled Herwehe falling to the floor and having some kind of convulsion or seizure.

She kept grabbing at her face, Cardenas testified. I panicked and went down to help Dr. Haddad, trying to move her arms away from her. I was scared. I was very much in shock.

Asked about the earlier procedure on colleague Nieto, Cardenas said Nieto screamed and had a lot of blood coming right out of her vaginal area. It wasnt like splashing out, but there was blood.

Cardenas said Haddad told Nieto: Dont tell Jaime how much pain you were in because she wouldnt want to go through with this.

On the stand Thursday was B Med Spa assistant manager Nieto, promoted from front-desk worker.

Attorney Vallero asked Nieto if written consent were obtained before her procedure.

Well, it was a verbal consent, not written, she said.

Nieto confirmed she had felt a high level of pain, but Haddad stopped after Nieto called for a halt. She said her vagina bled, but it wasnt excessive.

Was she asked to sign a consent form after the procedure?

Yes, Nieto said. She signed May 11, 2021 the day Herwehe balked and was fired.

Testimony resumes Monday, with closing arguments expected Tuesday or Wednesday.

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'Orgasm Shot' Caused Excruciating Pain, San Diego Jury Told in ... - Times of San Diego

How Hair-Loss Treatments Have Evolved Over Time – NewBeauty Magazine

Since the dawn of time, men and women have been combating sparse strands with a myriad of odd treatments and protocols. In the 21st century, we may have cracked the code and stopped the speed of shedding using breakthrough science and innovation.

In Ancient Egypt, castor oil and almond oil were often used to promote hair growth. They would also use concoctions made of dates, dog paws and donkey feet, says New York facial plastic surgeon Yael Halaas, MD. In India, they also had a tradition of standing on your head to increase blood flow to the scalp to improve hair loss, adds New York dermatologist Julie Russak, MD.

Spices, beetroot, myrrh, and some eyeopening ingredients like urine were used during the Greco-Roman era, when hair was an indicator of youth, wealth and status. The famous Greek physician Hippocrates believed that a mixture of spices, pigeon droppings, horseradish, beetroot, and opium could cure hair loss, which he suffered from himself, says Dr. Halaas.

In 8th century China, safflower oil, rosemary, Fo-Ti root, and various Chinese herbs were ground together with animal parts and used as a hair growth potion. Across Scandinavia, follicularly challenged Vikings would rub goose droppings on their heads in hopes of growing new strands. Saint Hildegard of Bingen, who lived in 12th century Germany, wrote of a baldness cure that called for leaving bear fat and ashes on the scalp for a long while.

Like the Ancient Egyptians, Victorians used castor oil, almond oil and gentle tonics, but also relied on rigorous scalp massages to promote blood flow. Silk nightcaps were also introduced to fight friction and minimize hair loss.

Modern-day restoration stems back to work done in Japan in the 30s, but it wasnt until the 50s that hair transplant surgery was born. A dermatologist named Dr. Norman Orentreich discovered that hair follicles could survive when moved from one site to another, says New York dermatologist Doris Day, MD. At first, the outcomes appeared unnatural in that clumps of follicles, called plugs, were placed with little regard to the natural hairline or final look.

Hair transplant surgery evolved in the 90s with Follicular Unit Transplants, where donor follicles are removed as a full strip from an area of healthy growth, explains Wayne, NJ facial plastic surgeon Jeffrey B. Wise, MD. Follicular Unit Extraction, a technique whereby grafts are harvested individually using a small punch, emerged in the 2000s.

Thankfully, today we dont rely on antiquated animal-based mixtures, but we are using follicle-stimulating growth factors. A treatment plan might include platelet-rich plasma injections, topicals, supplements like Nutrafol, nutritional changes, and lasers, notes Dr. Day. Doctors may prescribe medications like finasteride and topical minoxidil says Dr. Russak. Recently, low-dose oral minoxidil has also emerged as an effective hair growth solution.

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Dermatologist Jessie Cheung on How to Make Your Penis Bigger – Men’s Health

NO SURPRISE TO anyone whos been living on planet Earth, but a lot of men want to have a bigger penis. The thing is, we cant go to the gym, do three sets of dumbbell penis reps, and get a larger schlong. If it were that easy, nearly every guy would be walking around with a snake in his pants.

Still, there actually are some things you can do to get a bigger penis, but many of these procedures are not cheap and come with some serious health risks. Nevertheless, we know you're probably curious about the wild world of penis enlargement, which is why we reached out to Jessie Cheung, M.D., a board-certified dermatologist who specializes in some of these techniques. Cheung has been a dermatologist for nearly 20 years, and six years ago, she moved from doing medical dermatology to focusing exclusively on cosmetic and sexual dermatology.

In addition to standard facial cosmetic procedures, Cheungwho's based in Manhattan and Chicagoperforms a slew of penis procedures, including fillers, fat injections, Bocox (that's Botox for your cock, FYI), and Emsella (a form of electromagnetic therapy that helps with premature ejaculation and erection strength.)

We interviewed Cheung about her dermatological methods for making patients' penises bigger, longer, and even capable of lasting longer during sex.

This interview has been lightly edited and condensed for clarity.

I dont want to brag, but a lot, hundreds. As a dermatologist, I'm used to looking at skin everywhere, including the penis, anus, scrotum, and perineum, and dealing with warts, hemorrhoids, and fissures. I stopped doing medical dermatology years ago and now focus on cosmetics, hormones, and sexual health. So that brings in men who need help with their erectile function, libido, premature ejaculation, and men who have purely cosmetic issues. The big one, of course, is increasing their penis size.

Actually, I see more men who complain about erectile dysfunction instead of size, but they always say that even if they are happy with their size, they wouldn't mind more length or girth.

I give them statistics: Numbers are facts. Interestingly, many of my men who want bigger penises have above-average length and girth. I think porn makes them lose touch with reality, just like we're seeing social media distort our perception of beauty.

Penis length must be 2.5 standard deviations below the average for that age to be considered a micropenis. For adults, that is 9.3 cm when stretched or 3.6 inches. In my office, I consider it a micropenis if they are too short to penetrate their partner.

Not that often. I would say my whole career, probably two that were so small they couldn't penetrateand that's really short. When its that small, they may want surgical intervention, and I dont do penis surgeries. So because of that, I don't see many men with a proper micropenis.

Yeah, so I perform filler injections. I also perform P-shots, which are designed to treat ED but have the additional benefit of increasing size, specifically girth. P-shots involve injecting biological substances such as Platelet-rich plasma (PRP). PRP is a source of growth factors for blood vessels and tissue, so activating the hibernating stem cells in the arteries and nerves stimulates repair and the production of healthy tissue.

P-shots start at $1800 and increase depending on the protocol used.

Ill try not to be too technical, but we draw your blood in these special tubes. We spin it down on the centrifuge, and on the top coat, there's a layer that's kinda yellowy, that's very rich with platelets, which contains eight to ten growth factors that are good for your blood vessels, collagen, and stem cell activation. So we inject that into places where you want to turn on stem cells, whether into your scalp to grow hair, your skin to help with wound healing, or the penis to activate stem cells to make blood vessels and nerves again. That said, PRP is about 10 to 15 years old. I prefer to use exomes.

So, I perform a topical infusion of exosomes, which really is the cutting edge of regenerative medicine. Exosomes are basically little email packets of information that your stem cells secrete to turn each other on and talk to each other. And they're filled with RNA, proteins, and peptides. Exomes have hundreds of more growth factors than PRP. They're also anti-inflammatory. So I use exosomes the exact same way I use P-shots, to help with ED, functionality, and size.

Anti-inflammation helps prevent tissue from aging. So in the case of penises, this will help you retain your functionality and erection strength as you age.

Fat is a great filler, and since fat is full of stem cells, I recommend fat for improving size and restoring erectile function. You will see increased girth and can regain lost length, both flaccid and erect.

A fat transfer to the penis is very straightforward. The injection technique is similar to how we inject the penis with regular fillers, but we are harvesting your own fat with gentle liposuction and processing the fat with PRP or exomes. I like to take fat from the pubic mound, which helps to expose more of the base of the penis to create more visible length. I call it pulling the turtle out of the shell.

Fat is a very cost-effective filler, and since fat functions as a natural implant, it lasts much longer than other fillers. The most significant benefit of using fat is the improvement of functionality, as the wound-healing activation of stem cells will target nerves and blood vessels to improve sensitivity and circulation. I like to transfer at least 20 mL of fat, which starts at $8,000.

There are risks associated with any injection! But understanding the anatomy and potential complications will mitigate those risks. For example, you don't want any material getting into large arteries, which can cause tissue to die. You also have to respect the layers and boundaries of the penis to avoid migration of the filler (i.e., the filler all moving to one place and sitting there). Bruising, swelling, uneven appearance, and infection are potential complications that I warn my patients about.

No, I have never had a patient who asked for a smaller penis. But penises do shrink over time, as testosterone levels fall and there is a decrease in blood flow. The blood vessels and tissue scar down and get stiff, so they can't stretch and fill up with blood for a full erection. As a result, men will notice their penis looking smaller while flaccid and erect and report softer erections.

Typically men in their fifties and sixties, though Ive seen men coming and seeking help for their shrinkage in their thirties.

Staying healthy [and] keeping your hormone levels optimized. [And you do that by] having a good quality of sleep, a healthy diet, keeping stress levels low, and not smoking. So things that are generally thought of as bad for you will negatively affect your penis size as you age.

Yes, my patients love Bocox! It helps with size and erections. Botulinum toxin works by relaxing the smooth muscle in the blood vessels of the penis. This means the blood vessels are more dilated and filled with blood at rest, so the penis hangs longer and thicker when flaccid. So its great if youre a grower and not a shower. But even with an erection, the penis is even more full of blood than usual, so it is harder and may be thicker. Bocox is a relatively safe treatment. It's usually two pokes after the application of a topical numbing cream. Risks include mild bruising and swelling.

So it's electromagnetic therapy. Basically, you're sitting on a chair, and a powerful magnet is at the chair's base. That magnet makes your pelvic floor muscles activate. So essentially, you're doing kegel exercises, whether it be for the penis, the vagina, or the anus. For the penis, that can help with premature ejaculation, but also erection strength and even size because of the increased blood flow. We have men who do Emsella for the anus, specifically sphincter control. There's a statistic that you complete over 11,000 Kegel exercises in 28 minutes on the Emsella chair. So it's very legit, and I love using it on my patients.

I will refuse to treat a patient who has unrealistic expectations. Beyond that, everyone has their own desired aesthetic, so I won't judge a man if he wants to have a huge penis. To each their own!

Social media and porn have created unrealistic expectations for bodies, faces, and genitalia. It's difficult to maintain a smooth, pink anus or vagina or penis or even nipples as we age, and sexual confidence is at an all-time low. Sex is excellent for your physical and mental health and appearance, so a therapeutic procedure that encourages sexual wellness and confidence is not really up to public judgment. It's a private health issue.

I had a patient who had filler injections done elsewhere. He had 15 syringes done in one session, and all the filler clumped up at the head of his penis. It was this huge blob. It looked like a golf ball.

So he came after it was botched to get it fixed. But didnt want to get the filler removed. So what I did was add more filler at the shaft and base, essentially to blend it in better.

Aside from the usual wows, what's memorable are the stories I hear when my patients return: sex multiple times a day, getting propositioned on Snapchat, video parties, and underground fame. My patients are definitely more confident. I had one patient who was too short to penetrate his partner, and after a combination of hormones, a P-shot, and fat transfer, he was finally able to have penetrative sex!

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Dermatologist Jessie Cheung on How to Make Your Penis Bigger - Men's Health

Stem cell research can help people with hard-to-heal wounds – EurekAlert

Advances in burns treatment open up new possibilities for healing other complicated wounds. For the first time, stem cells produced in compliance with the regulations governing the manufacture of medicinal products, are now being tested as a treatment for hard-to-heal leg ulcers in Linkping, Sweden.

Using stem cells in the treatment of hard-to-heal wounds and burns is a new method under development. Its success depends on close collaboration between researchers and health care staff. The objective is clear: meeting health care needs.

I recall a man in his 40s, this was a couple of months after I came to Linkping Universityas a researcher, who was fighting for his life. Im sad to say he died. If wed had the technologies we have now, we might have been able to help him. I still think about him, says Ahmed Elserafy, who was recruited to Linkping University (LiU) as a researcher to find the right type of cells to treat wounds.

One of Swedens two national Burn Centres is located at Linkping University Hospital. Here, near-clinical and internationally recognised research is carried out next to advanced burns care. One important task is developing the burn care of the future.

Burn treatment has been the same for a very long time and is based on taking skin grafts from the patient for transplant to the wound area. Our research focuses on finding other ways to cover open wounds, says Folke Sjberg, professor at LiU and consultant at the Linkping national Burn Centre (Brnnskadecentrum).

But not only burns cause serious open wounds. A very large group of wounds identified as hard-to-heal wounds, cause extensive suffering and present a difficult health care challenge.

There are significant differences between burns and hard-to-heal wounds. Burns occur suddenly. Burn patients do not normally have underlying diseases adversely affecting the healing of wounds. A hard-to-heal wound, however, is caused by underlying conditions that impair healing, such as diabetes, or multimorbidity in the case of elderly people.

The prognosis is grim for the around 100,000 people in Sweden with hard-to heal wounds. In more than half of the cases, such wounds lead to amputation of the limb affected. Hard-to-heal wounds are most often treated with dressings and wound care products. It is also possible to transplant the patients own skin to the wound.

The team of researchers and care staff have developed a model for growing new skin cells from a tissue sample from the patient. The cells are administered to the wound area in the form of a solution. The team has shown that the wound heals from the edges to the centre, just like it would naturally. Most wounds have shrunk to only half the size after 15 days.

This model forms the basis for the researchers next step, where they investigate the viability of using cells from another person instead of the patients own.

Cells from elderly patients are not optimal for transplantation. What were doing now is that we use cells from younger individuals with much better healing potential, says Folke Sjberg.

Specialist nurse Matilda Karlsson and consultant Moustafa Elmasry are working on a clinical study at the Burn Centres wound clinic. It is the first study in the world where stem cells, produced in compliance with the regulations governing the manufacture of medicinal products, are tested on patients with hard-to-heal leg ulcers.

Its a revolutionising, active treatment compared with traditional treatment using dressings or transplantation of the patients own skin, which is a very invasive procedure, says Moustafa Elmasry.

The cells used are derived from fat harvested from plastic surgery patients. The researchers collaborate with the company Xintela in Lund, which purifies a well-defined group of stem cells. What is unique about stem cells is that they can be developed into any type of cell in the body. Studies have shown that even if the cells come from another person, the bodys immune defence system does not react to them.

The study, which will comprise eight patients, is in its start-up phase. As with all clinical studies, the first step is to find out whether the treatment is safe. The researchers hope that the stem cells will also have a positive effect on wound healing. Should this turn out to be the case, it will be interesting to develop the process to ensure a sufficiently large amount of cells at a reasonable cost, to enable broad application in health care. The larger the wound, the more cells are required.

If the treatment proves successful, the researchers hope that, in the long term, it can also be used to cover extensive burns. Matilda Karlsson does not hesitate for a second when asked what they hope their research will eventually lead to:

A product that can heal all types of hard-to-heal wounds, with no need for skin grafts from the patient. This could hopefully save people from amputation of the limbs affected and, in the case of severe burns, save lives.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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Girl in the fight of her life looks for stem cell donor – BlackburnNews.com

By Paul Pedro April 12, 2023 11:28am

A little girl who desperately needs a Stem Cell Transplant to survive is asking area residents for help.

Zoe Dudzianiec, 7, of Tecumseh has a rare disease called Diamond-Blackfan Anemia, which is a very rare bone marrow disorder with no cure.

She has been getting treatment since birth and must receive 10 hours of medical treatment every day. Zoe also gets blood transfusions every 10 days at Sick Kids Hospital in Toronto because the blood she requires isnot available to her in Windsor anymore.

Her best treatment option is a stem cell transplant. She needs to rely on the generosity of a stranger to save her life by registering as a potential donor, said officials with The Katelyn Bedard Bone Marrow Association.

They are hosting a swab clinic at St. Clair College in Chatham next week to find a potential donor for Zoe. The clinic will be held at the Chatham Campus of St. Clair College on Monday, April 17, 2023 from 10 a.m. to 2 p.m. The swabbing event will be held in the lobby of the main building at 1001 Grand Avenue West.

Zoe needs someone who shares her Middle Eastern/European ethnic background to donate stem cells to save her life.

Sign up here to become a stem cell donor if you cant make it to the clinic in Chatham. Your stem cells could give her the carefree childhood she deserves. Those wishing to register must be between the ages of 17 and 35. Potential donors of all ethnic backgrounds are welcome, according to organizers.

Diversification of the Canadian Registry is vital, organizers said.

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Clinical Commentary: Tawbi Assesses Toxicities of Therapies in … – Targeted Oncology

We have randomized phase 3 data for pembrolizumab [Keytruda], nivolumab, andnivolumab plus ipilimumab [Yervoy], so I completely agree that all of these [agents are considered] category 1 treatments by the NCCN [National Comprehensive Cancer Network] because all have shown improvements over single-agent ipilimumab.1 That is kind of where the category 1 comes from when including overall survival [OS] benefit. I consider NCCN guidelines to bevery safe. They dont include options just because they exist.

However, [combination] pembrolizumab and low-dose ipilimumab has been tried in 1 large single-arm study called KEYNOTE-29 [NCT02089685] and [found to be]safer than the combination of ipilimumab and nivolumab or high-dose ipilumumab.2 Yet, most of[the] relevant data are from a second-line study that showed about a 25% response rate in the second line low dose of ipilimumab or pembrolizumab. So, personally, I dont necessarily agree with this recommendation as a first-line regimen for low-dose ipilimumab/ pembrolizumab, but obviously this is up for discussion.

Relatlimab is a novel antibody that blocks LAG3. Its one of those interesting receptors and is quite different than PD-1. Its expressed on activated T cells and exhausted T cells. Initially, people were thinking that it has an association with MHC class II, the primary ligand, but more and more data are arising to show that its directly associated with the TCR CD3, basically signaling cascade.3 It actually modulates TCR signaling, so it makes a bigger impact in a place where theres a lot more TCR signaling happening, and thats probably why it works better in the first line than in the second line.

We just published in Nature [results of a] neoadjuvant study where the response rate in our neoadjuvant patients was 57%, so the earlier you use it, the more signaling happens through TCR, and the more you can modulate anti-LAG3.4 Now, the RELATIVITY-047 study [NCT03470922] was a phase 3 trial followed by the FDA approval of nivolumab plus relatlimab [for patients 12 years and older with unresectable/metastatic melanoma].5,6

With ipilimumab/nivolumab in any setting, you get grade 3 to 4 toxicity of at least 50%, and the highest discontinuation rate because of an adverse event [AE] was 36% in the CheckMate 067 [NCT01844505] study.7 [The rate of any grade 3/4 AEs with] nivolumab and relatlimab was 21%, and this is why I do feel like its slightly more toxicbut the pattern oftoxicity is similar [Table7]. With [this combination] every toxicity Ive encountered feels the same as when you encounter a singleagent toxicity. It doesnt feel a lot more recalcitrant and its not a lot harder, and you get 1 toxicity per patient, just like you would get it with the single-agent PD-1 inhibitor. The other factor that I share with [patients] is that Ive run 2 trialswith it. Both are randomized, double-blind studies vs nivolumab as a single agent. I had a fellow in my clinic who was seeing a patient on the adjuvant trial,[and I challenged him to find out which treatment the patient was on based on toxicity presentation]. He told me he wasnt sure he could do that and thats the point. If we were treating the patient with ipilimumab/nivolumab, you would know which arm. If it was blinded and [using] ipilimumab/nivolumab, you would know which arm, but because its nivolumab/relatlimab, it was impossible to tell.

The phase 1 [portion of the] study had about 25 patients treated with [relatlimab as a] single agent in the second line, and it had no activity, but we only use it in combination because of the way it works; it has a lot more potential for working only in combination because it potentiates the TCR signaling. So once you use a PD-1 [inhibitor], you increase the TCR signaling, and then the LAG3 amplifies that signal and makes it better.

If you have an immune-suppressed individual who is already [being treated in the] second line and [is] resistant to immunotherapy, the TCR signaling is going to be so much more limited, and youll not [be] able to reverse the exhaustion with either single agent, whereas with a combination, you get about a 13% response in the second line [From the Data5]. Now, 13% [is a smaller response] and 1 out of 7 patients responded, so Im not surprised that some patients feel like it never works. Every time Ive used it in the metastatic [setting] in the second or third line, Im just candid with patients [and I discuss how much of a response] I expect. I dont do 3 months in that situation. I just repeat their scans in 2 months because if they are going to progress I may want to do something different.

The data that we have [show] that if the patient is requiring steroids at the time of initiation, when youre starting ipilimumab and nivolumab, their chances of a response are only 18%, so its limited. If you have already treated them with ipilimumab and nivolumab, and now youre treating the toxicity with steroidsI would focus on finishing the steroids completely tapering them off if you canand thenconsider rechallenging.

In CheckMate 067, the study that I ran in that population, if you had a grade 3 to 4 toxicity, they basically never rechallenged you with immunotherapy. They just took you off. We allowed [rechallenging] on the study after they taper off steroidsand we got away with it about half the time. The other halfwould get hepatitis back or other things back, but you can get away with a rechallenge about half the time.

KEYNOTE-006 [NCT01866319], which compared 2 doses of pembrolizumab with single agent ipilimumab,is interesting because we used to dose [patients] so high, [at about] 10 mg/kg every 2 weeks.8 The 200 mg that you currently use every 3 weeks is equivalent to 3 mg/kg every 3 weeks, so imagine how much more of a dose that was. And it didnt matter, so theres not a lot of dose-response relationship with pembrolizumab. By even decreasing the dose by almost twothirds, you still get the same outcome.

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American Association for Cancer Research Recognizes 2022-2023 … – American Association for Cancer Research (AACR)

PHILADELPHIA TheAmerican Association for Cancer Research(AACR) is proud to announce its newest class of grant recipients.

Since 1993, the AACR has allocated $133 million and awarded 880 research grants to support hundreds of scientists devoted to advancing the understanding, prevention, diagnosis, and treatment of cancer. Our grants support researchers domestically and abroad at every stage of their careers, representing a global commitment to cancer prevention, early detection, interception, and cure.

Fellowships

2021 AACR-Bristol Myers Squibb Immuno-oncology Research Fellowship

2022 AACR-Amgen Fellowship in Clinical/Translational Cancer Research

2022 AACR-Day One Biopharmaceuticals Pediatric Cancer Research Fellowship

2022 AACR-Exelixis Renal Cell Carcinoma Research Fellowship

2022 AACR-Genmab Non-Hodgkin B-Cell Lymphoma Research Fellowship

2022 AACR-Merck Cancer Disparities Research Fellowship

2022 AACR-Merck Immuno-oncology Research Fellowship

2022 AACR-Mirati Cancer Chemical Biology Research Fellowship

2022 AACR-QuadW Foundation Sarcoma Research Fellowship, in Memory of Willie Tichenor

2023 AACR Fellowship to Further Diversity, Equity, and Inclusion in Cancer Research

2023 AACR-Bristol Myers Squibb Immuno-Oncology Research Fellowship

2023 AACR-D-Team Sarcoma Research Fellowship

2023 AACR-D-Team Sarcoma Research Fellowship

2023 AACR-Incyte Immuno-oncology Research Fellowship

2023 AACR-John and Elizabeth Leonard Family Foundation Basic Cancer Research Fellowship

2023 AACR-QuadW Foundation Sarcoma Research Fellowship, in Memory of Willie Tichenor

Career Development Awards

2022 AACR Career Development Award to Further Diversity, Equity, and Inclusion in Cancer Research

2022 AACR Career Development Award to Further Diversity, Equity, and Inclusion in Cancer Research

2022 AACR Career Development Award to Further Diversity, Equity, and Inclusion in Cancer Research

2022 AACR Career Development Award to Further Diversity, Equity, and Inclusion in Cancer Research

2022 AACR Career Development Award to Further Diversity, Equity, and Inclusion in Cancer Research

2022 AACR Career Development Award to Further Diversity, Equity, and Inclusion in Clinical Cancer Research

2022 AACR Career Development Award to Further Diversity, Equity, and Inclusion in Clinical Cancer Research

2022 AACR Career Development Award to Further Diversity, Equity, and Inclusion in Clinical Cancer Research

2022 AACR-MPM Oncology Charitable Foundation Transformative Cancer Research Grant

2022 AACR-MPM Oncology Charitable Foundation Transformative Cancer Research Grant

2022 AACR-Novocure Career Development Award for Tumor Treating Fields Research

2022 Victorias Secret Global Fund for Womens Cancers Career Development Award, in Partnership with Pelotonia & AACR

2022 Victorias Secret Global Fund for Womens Cancers Career Development Award, in Partnership with Pelotonia & AACR

2022 Victorias Secret Global Fund for Womens Cancers Career Development Award, in Partnership with Pelotonia & AACR

2022 Victorias Secret Global Fund for Womens Cancers Career Development Award, in Partnership with Pelotonia & AACR

2022 Victorias Secret Global Fund for Womens Cancers Career Development Award, in Partnership with Pelotonia & AACR

2023 Lustgarten Foundation-AACR Pancreatic Cancer Career Development Award, in Honor of John Robert Lewis

2023 Lustgarten Foundation-AACR Pancreatic Cancer Career Development Award, in Honor of Ruth Bader Ginsburg

Independent Investigator Awards

2021 AACR-Bayer Innovation and Discovery Grant

2021 AACR-Bristol Myers Squibb Midcareer Female Investigator Grant

2021 AACR-Novocure Tumor Treating Fields Research Grant

2022 Friends of the AACR Foundation Early Career Investigator Award

2023 Lustgarten Foundation-Swim Across America-AACR Pancreatic Cancer Early Detection Research Grant

2023 Victorias Secret Global Fund for Womens Cancers Rising Innovator Research Grant, in Partnership with Pelotonia & AACR

2023 Victorias Secret Global Fund for Womens Cancers Rising Innovator Research Grant, in Partnership with Pelotonia & AACR

2023 Victorias Secret Global Fund for Womens Cancers Rising Innovator Research Grant, in Partnership with Pelotonia & AACR

2023 Victorias Secret Global Fund for Womens Cancers Rising Innovator Research Grant, in Partnership with Pelotonia & AACR

2023 Victorias Secret Global Fund for Womens Cancers Rising Innovator Research Grant, in Partnership with Pelotonia & AACR

Grants Supporting Researchers in Africa

2022 Beginning Investigator Grant for Catalytic Research (BIG Cat)

2022 Beginning Investigator Grant for Catalytic Research (BIG Cat)

2022 Beginning Investigator Grant for Catalytic Research (BIG Cat)

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American Association for Cancer Research Recognizes 2022-2023 ... - American Association for Cancer Research (AACR)