Stem Cell Clinic

Ambys Medicines to Present Data from Universal Human Hepatocyte Program at the 2022 ISSCR Annual Meeting – Galveston County Daily News

By Stem Cell Medicine

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Ambys Medicines to Present Data from Universal Human Hepatocyte Program at the 2022 ISSCR Annual Meeting - Galveston County Daily News

Local Father Battling Cancer to Host Blood Stem Cell Drive at SH Sprint Triathlon – The Hudson Indy Westchester’s Rivertowns News – – The Hudson…

By Stem Cell Medicine

Eugene Doherty is a local fire captain and father of a nine-year-old daughter.

June 9, 2022

By Rick Pezzullo

A local fire department captain is on a mission to register potential stem cell donors to help others like himself who have been stricken with cancer.

Eugene Doherty, 46, is battling acute lymphoblastic leukemia (ALL) but was fortunate enough to find a matching donor in his family, which is not often the case for 70 percent of people suffering from blood-related illnesses who must seek a match from a stranger to save their life.

Originally from Ireland, Doherty resides in Sleepy Hollow and has volunteered for 12 years with the Sleepy Hollow Sprint Triathlon. Prior to his diagnosis, he was an active triathlete.

This weekend, Doherty is teaming up with DKMS, the worlds largest blood stem cell donor center, at Kingsland Point Park at 299 Palmer Ave. in Sleepy Hollow to try to register potential donors.

Anyone in good health between the ages of 18 and 55 is encouraged to attend. Potential registrants will review medical eligibility, fill out a registration form, swab the insides of their cheeks, and return their completed packet before leaving the drive. Anyone who cannot attend the registration drives can register by ordering a free swab kit viahttps://www.dkms.org/get-involved/virtual-drives/sleepy-hollow-sprint-triathlon-donor-drive.

The registration drive will take place Saturday, June 11 from 9 to 11 a.m. and Sunday, June 12 from 7 a.m. to noon.

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Local Father Battling Cancer to Host Blood Stem Cell Drive at SH Sprint Triathlon - The Hudson Indy Westchester's Rivertowns News - - The Hudson...

Bridge Therapy For Neuroblastoma: A Game-Changing Paediatric Cancer Treatment | TheHealthSite.com – TheHealthSite

By Stem Cell Medicine

Patients Suffering From Neuroblastoma May Benefit From Bridge Therapy

Written by Kinkini Gupta | Updated : June 9, 2022 12:31 PM IST

Neuroblastoma, a pediatric cancer that arises from immature nerve cells has a very high risk of recurrence among approximately half of the children who are already suffering from cancer. With ever-advancing medicine and technology, researchers however have discovered a new therapy called the 'bridge therapy.' A study conducted and published the journal Cancer states that patients suffering from neuroblastoma may benefit from this therapy between induction and consolidation treatments. Neuroblastoma can often be cured by surgical removal of tumors followed by chemotherapy. These patients often receive induction therapy composed of various drugs used to carry out chemotherapy and surgery. This is followed by consolidation therapy, which involves a high-dose chemotherapy and stem cell transplants. Unfortunately, these treatments, which are currently in use, have not been successful in many children.

This newly discovered therapy will include immunotherapy drugs that have demonstrated anti-neuroblastoma activity in combination with chemotherapy, radiolabeled MBIG or combinations of chemotherapeutic agents. Research suggests that this therapy could offer some benefit to cancer patients. To examine the effectiveness of this therapy, a study including the data from 201 patients diagnosed with neuroblastoma at various hospitals from 2008-2018 were taken into consideration. Some patients were treated in three groups with different approaches based on physician, institutional or family preferences. The three steps were:

This study was especially done to find out if patients are responding well to bridge therapy prior to consolidation with stem cell transplant. They found out that the following results with patients who directly underwent consolidation:

Response to induction therapy is known to increase survival rate, and the study suggests that bridge therapy prior to consolidation therapy benefits patients with high-risk neuroblastoma with a poor response to induction. Also, response to bridge therapy prior to consolidation therapy is associated with outcome, and patients with less than a partial response may benefit from alternative treatment approaches. An accompanying editorial discusses the findings and agrees that future studies of bridge therapy for patients who do not experience a favorable response following standard induction therapy are needed.

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Bridge Therapy For Neuroblastoma: A Game-Changing Paediatric Cancer Treatment | TheHealthSite.com - TheHealthSite

Expression of stem cell biomarkers Bmi1 and KLF4 in osteosarcoma and its clinical significance – Newswise

By Stem Cell Medicine

Abstract:

Objective To observe the expression of osteosarcoma stem cell biomarkers Bmi1 and KLF4 in osteosarcoma tissues and explore their value in the diagnosis, treatment and prognosis of osteosarcoma.

Methods Using retrospective research methods, 51 patients (28 males and 23 females) with osteosarcoma who were surgically resected and diagnosed by pathology in the Second Hospital of Shanxi Medical University from October 2009 to July 2019 were used as the experimental group. The age of cases varies from 10 to 67 (average 27.04) years old, and bone tissues adjacent to the tumor were taken from 10 samples as the normal control group. Immunohistochemical method was used to assess the expression levels of Bmi1 and KLF4 in 51 patients with osteosarcoma and 10 cases of paraneoplastic bone tissue specimens. Chi-square test was applied to analyze the relationship between the expression of Bmi1 and KLF4 and the clinical pathological data of patients. Correlation analysis was analyzed by the number of connections. The survival rate of patients was calculated by the Kaplan-Meier method. The log rank univariate analysis and Cox regression multivariate analysis were carried out to evaluate the prognostic value.

Results The positive expression rates of Bmi1 and KLF4 in the osteosarcoma group were 78.43% (40/51) and 80.39% (41/51), respectively, and in the bone tissue group were both 3/10. The difference of the positive expression rates of Bmi1 and KLF4 in the osteosarcoma group and bone tissue group was statistically significant (P < 0.05). In osteosarcoma group, the expression levels of Bmi1 and KLF4 were positively correlated (R = 0.399, P < 0.01). Bmi1 protein-positive, KLF4 protein-positive, and Bmi1 and KLF4 protein double-positive expression were statistically significant in Enneking surgical staging, lung metastasis, and pathological typing (all P < 0.05), but there was no statistically significant difference between different ages, genders, local recurrences, and tumor sizes (all P > 0.05).

Conclusion The expression of Bmi1 and KLF4 in osteosarcoma tissue was significantly higher than that in surrounding bone tissues, and their positive expression is a risk factor for the prognosis of patients with osteosarcoma.

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Expression of stem cell biomarkers Bmi1 and KLF4 in osteosarcoma and its clinical significance - Newswise

This Key Protein Is Essential for Brain Cell Longevity and Growth – SciTechDaily

By Adult Stem Cells

Recent research finds that the insulin receptor protein (INSR) is pivotal for brain stem cell longevity and growth.

Stem cells are the bodys raw materials they are the cells that give rise to all other cells with specialized functions. In the right circumstances, stem cells in the body divide to produce new cells known as daughter cells.

Humans contain neural stem cells in their brains. These brain stem cells may develop into neurons, astrocytes, or oligodendrocytes. Because neural stem cells generate all of the brains cell types, there is a multitude of stem cells in an embryos brain. In fact, the majority of brain cells are born in the embryo stage. These cells persist till adulthood and can be found in particular regions of the brain. Neural stem cells are essential for your brain to properly function.

According to research from Rutgers University, a receptor that was first identified as necessary for insulin action and is also found on neural stem cells found deep in the brains of mice is crucial for brain stem cell longevity, a finding that has important implications for brain health and future therapies for brain disorders.

The research, published in the journal Stem Cell Reports, focuses on a particular protein known as the insulin receptor (INSR), which is prevalent in neural stem cells in the brains subventricular zone. Neural stem cells give rise to the entire nervous system throughout development and persist into adulthood. Over the course of a persons life, these neural stem cells generate new neurons and non-neuronal cells that help the brains infrastructure and function.

Separately, while studying brain tumors, the researchers discovered that INSR plays an important role in the survival and maintenance of a population of specialized brain cancer cells known as glioblastoma (GBM) stem cells. They were able toreducethe growth of those primitive tumor-forming cells by inactivating the INSR in GBM stem cells.

Its important to understand the molecular mechanisms that are critical for the growth and sustenance of the brains stem cells under normal and abnormal growth states, said study author Steven Levison, a professor of neuroscience in the Department of Pharmacology, Physiology, and Neuroscience and director of the Laboratory for Regenerative Neurobiology at Rutgers New Jersey Medical School. Comprehending the signals that regulate these primitive cells could one day lead to new therapeutics for brain disorders.

Many neurodegenerative disorders, such as multiple sclerosis, Parkinsons disease, and Alzheimers disease, are connected with the destruction of brain cells, said co-author Teresa Wood, a Distinguished Professor and Rena Warshow Endowed Chair in Multiple Sclerosis in the Department of Pharmacology, Physiology, and Neuroscience at Rutgers New Jersey Medical School.

If we could influence how brain stem cells function then we can use this knowledge to replace diseased or dead brain cells with living ones, which would advance the treatment of neurological diseases and brain injuries, said Wood, who also teaches and conducts research at the Cancer Institute of New Jersey.

Cell receptors such as INSR are protein molecules that reside on the surfaces of cells. Substances, either natural or human-made, that open the lock of a receptor can spur a cell to divide, differentiate or die. By identifying which receptors perform these functions on specific cell types, and by understanding their structures and functions, scientists can design substances that act as keys to receptors, to turn them on or off.

Previous studies by this research team had shown that a certain key, the signaling protein that is known as the insulin-like growth factor-II (IGF-II), was necessary to maintain the neural stem cells in the two places of the adult brain that harbor these primitive cells. In the current experiment, scientists were looking to identify the receptor. To do so, they used genetic tools that allowed them to both delete the INSR and introduce a fluorescent protein so they could track the neural stem cells and the cells they generate. They found that the numbers of neural stem cells in the subventricular zone in the brains of mice lacking the INSR collapsed.

Adult neurogenesis the idea that new cells are produced in the adult brain has been a burgeoning field of scientific inquiry since the late 1990s, when researchers confirmed what had only been a theory in lab studies of human, primate, and bird brains. Neural stem cells in the adult are stem cells that can self-renew and produce new neurons and the supporting cells of the brain, oligodendrocytes, and astrocytes.

Given the widespread interest in stem cells as well as interest in whether alterations to adult stem cells might contribute to cancer, our research findings should be of interest, Levison said.

Other Rutgers authors included Shravanthi Chidambaram, Fernando J. Velloso, Deborah E. Rothbard, Kaivalya Deshpande, and Yvelande Cajuste of the Department of Pharmacology, Physiology, and Neuroscience at Rutgers New Jersey Medical School. Other participating investigators were at the University of Minnesota, the Albert Einstein College of Medicine, and Brown University.

Reference: Subventricular zone adult mouse neural stem cells require insulin receptor for self-renewal by Shravanthi Chidambaram, Fernando J. Velloso, Deborah E. Rothbard, Kaivalya Deshpande, Yvelande Cajuste, Kristin M. Snyder, Eduardo Fajardo, Andras Fiser, Nikos Tapinos, Steven W. Levison and Teresa L. Wood, 5 May 2022, Stem Cell Reports.DOI: 10.1016/j.stemcr.2022.04.007

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This Key Protein Is Essential for Brain Cell Longevity and Growth - SciTechDaily

The Many Spheres in Which CO2 Chambers Show Their Strengths – MedicalExpo e-Magazine

By Adult Stem Cells

Without CO2 incubators, there would be no coronavirus vaccines today. They are also absolutely essential for cancer research. These multiple uses help save lives and cure many different diseases. We would now like to introduce you to some of the interesting facets of CO2 incubators.

Sponsored by BINDER GmbH.

CO2 incubators are being used to conduct research in laboratories across the globe. The Bioscience Institute Middle East, which is among the worlds leading centers for regenerative medicine, is also using an incubator to process the bodys own cells as well as for plastic surgery applications.

The cellswhich are multiplied in an incubatorare also used in tissue repair as well as for orthopedic and dermatological treatments. The Bioscience Institute only uses skin and fat tissue specimens from adult (mature) cells. Using the bodys owni.e., autologouscells eliminates the risk of rejection while also preventing the complication of graft-versus-host disease (an unwanted reaction of the donors immune cells).

To be even more specific: the CO2 incubators are predominantly used to incubate stem cells from mesenchyme tissue (undifferentiated connective tissue).

Here is how it works: first, cells are extracted from fat tissue. This process is performed by means of enzymatic disaggregation (separation) using various steps of filtration and centrifugation. The crucial stage here is the expansion, i.e., extracting as many stem cells as possible, which is why it is absolutely essential to create the best possible growth conditions.

Dr. Simona Alfano, a biologist at the Bioscience Institute, explained:

When incubating the cells, it is vitally important for the selected parameters to remain exactly constant across all levels.

And this is precisely where the CO2 chambers from BINDER come into their ownwith their reproducible growth conditions, constant climatic conditions, low risk of contamination and high level of safety.

Find out more about why the ph value is a key factor in cell and tissue cultures.

CO2 chambers also played an important role during the coronavirus pandemic: firstly, in the development of coronavirus vaccines and, secondly, to test drugs that may be used to treat COVID-19 on cells.

For this work, the major pharmaceutical companies required huge volumes of cellswhich they were able to acquire with the aid of an incubator. The newly developed active ingredients were then tested using the cells.

The new vaccines used in the fight against the coronavirus were also repeatedly tested on cells in laboratories and evaluated. An incubator proved to be an essential piece of equipment in a laboratoryparticularly during the coronavirus pandemic.

Read more on premium equipment for virus research.

The Institute of Medical Engineering at the Lucerne University of Applied Sciences and Arts has been carrying out research in the field of space biology. The research team, led by Dr. Fabian Ille, is assisted in its work by a CO2 chamber.

Cells from a bovine hoof are being incubated inside the cabinet at regular intervals until they are needed for a specific experiment. Recently, the cells were frozen and taken to the French city of Bordeaux by Dr. Simon West and a team of researchers.

The reason behind this trip was that the research team in Lucerne was selected by the European Space Agency (ESA) to take part in parabolic flights over the Atlantic. Shortly before the parabolic flights, which lasted for a total of three hours, the cells were removed from the incubator and moved to flight hardware that had been prepared specifically for this purpose and was under controlled temperature conditions.

The scientists from Lucerne wanted to use the parabolic flights to investigate how the cells respond and adapt to mechanical forces. These findings will help them in future attempts to cultivate cartilage that is of a stronger and better consistency, for example. In other words, it might be possible to remove cells from a patient, reproduce them with this innovative new method, and then use them again in the treatment of human patients.

Weightless conditions are helping us to make significant progress, said Dr. Ille, reflecting on the research project so far.

In laboratory tests that have already been carried out, West and Ille have been able to demonstrate in very broad terms that this process could work in the future.In these tests, weightless conditions were simulated using a random position machine. Here again, a CO2 chamber from BINDER was used.

Safety is the absolute top priority here.180C sterilization ensures, for example, that every trial series begins with a clean and fully sterile incubator. Whats more, the fanless design means that germs are not stirred up.

The result is optimal cell growth and absolutely no contamination from airborne germs. A deep-drawn inner chamber without corners or edges also enables the incubator to be cleaned thoroughly with ease. It is therefore no surprise that major pharmaceutical manufacturers choose specifically to put their trust in CO2 incubators from BINDER.

BINDER CO2 incubators are the perfect combination of a range of solutions180C hot air sterilization, rapid control, fixture-free interiors and absolutely zero consumables. For optimal cell growthsafe, reliable, smart, economicallook no further than BINDER.

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The Many Spheres in Which CO2 Chambers Show Their Strengths - MedicalExpo e-Magazine

‘Ghost heart’: Built from the scaffolding of a pig and the patient’s cells, this cardiac breakthrough may soon be ready for transplant into humans -…

By Adult Stem Cells

"It actually changed my life," said Taylor, who directed regenerative medicine research at Texas Heart Institute in Houston until 2020. "I said to myself, 'Oh my gosh, that's life.' I wanted to figure out the how and why, and re-create that to save lives."

That goal has become reality. On Wednesday at the Life Itself conference, a health and wellness event presented in partnership with CNN, Taylor showed the audience the scaffolding of a pig's heart infused with human stem cells -- creating a viable, beating human heart the body will not reject. Why? Because it's made from that person's own tissues.

"Now we can truly imagine building a personalized human heart, taking heart transplants from an emergency procedure where you're so sick, to a planned procedure," Taylor told the audience.

"That reduces your risk by eliminating the need for (antirejection) drugs, by using your own cells to build that heart it reduces the cost ... and you aren't in the hospital as often so it improves your quality of life," she said.

Debuting on stage with her was BAB, a robot Taylor painstakingly taught to inject stem cells into the chambers of ghost hearts inside a sterile environment. As the audience at Life Itself watched BAB functioning in a sterile environment, Taylor showed videos of the pearly white mass called a "ghost heart" begin to pinken.

"It's the first shot at truly curing the number one killer of men, women and children worldwide -- heart disease. And then I want to make it available to everyone," said Taylor to audience applause.

"She never gave up," said Michael Golway, lead inventor of BAB and president and CEO of Advanced Solutions, which designs and creates platforms for building human tissues.

"At any point, Dr. Taylor could have easily said 'I'm done, this just isn't going to work. But she persisted for years, fighting setbacks to find the right type of cells in the right quantities and right conditions to enable those cells to be happy and grow."

"We were putting cells into damaged or scarred regions of the heart and hoping that would overcome the existing damage," she told CNN. "I started thinking: What if we could get rid of that bad environment and rebuild the house?"

Soon, she graduated to using pig's hearts, due to their anatomical similarity to human hearts.

"We took a pig's heart, and we washed out all the cells with a gentle baby shampoo," she said. "What was left was an extracellular matrix, a transparent framework we called the 'ghost heart.'

"Then we infused blood vessel cells and let them grow on the matrix for a couple of weeks," Taylor said. "That built a way to feed the cells we were going to add because we'd reestablished the blood vessels to the heart."

The next step was to begin injecting the immature stem cells into the different regions of the scaffold, "and then we had to teach the cells how to grow up."

"We must electrically stimulate them, like a pacemaker, but very gently at first, until they get stronger and stronger. First, cells in one spot will twitch, then cells in another spot twitch, but they aren't together," Taylor said. "Over time they start connecting to each other in the matrix and by about a month, they start beating together as a heart. And let me tell you, it's a 'wow' moment!"

But that's not the end of the "mothering" Taylor and her team had to do. Now she must nurture the emerging heart by giving it a blood pressure and teaching it to pump.

"We fill the heart chambers with artificial blood and let the heart cells squeeze against it. But we must help them with electrical pumps, or they will die," she explained.

The cells are also fed oxygen from artificial lungs. In the early days all of these steps had to be monitored and coordinated by hand 24 hours a day, 7 days a week, Taylor said.

"The heart has to eat every day, and until we built the pieces that made it possible to electronically monitor the hearts someone had to do it person -- and it didn't matter if it was Christmas or New Year's Day or your birthday," she said. "It's taken extraordinary groups of people who have worked with me over the years to make this happen."

But once Taylor and her team saw the results of their parenting, any sacrifices they made became insignificant, "because then the beauty happens, the magic," she said.

"We've injected the same type of cells everywhere in the heart, so they all started off alike," Taylor said. "But now when we look in the left ventricle, we find left ventricle heart cells. If we look in the atrium, they look like atrial heart cells, and if we look in the right ventricle, they are right ventricle heart cells," she said.

"So over time they've developed based on where they find themselves and grown up to work together and become a heart. Nature is amazing, isn't she?"

As her creation came to life, Taylor began to dream about a day when her prototypical hearts could be mass produced for the thousands of people on transplant lists, many of whom die while waiting. But how do you scale a heart?

"I realized that for every gram of heart tissue we built, we needed a billion heart cells," Taylor said. "That meant for an adult-sized human heart we would need up to 400 billion individual cells. Now, most labs work with a million or so cells, and heart cells don't divide, which left us with the dilemma: Where will these cells come from?"

"Now for the first time we could take blood, bone marrow or skin from a person and grow cells from that individual that could turn into heart cells," Taylor said. "But the scale was still huge: We needed tens of billions of cells. It took us another 10 years to develop the techniques to do that."

The solution? A bee-like honeycomb of fiber, with thousands of microscopic holes where the cells could attach and be nourished.

"The fiber soaks up the nutrients just like a coffee filter, the cells have access to food all around them and that lets them grow in much larger numbers. We can go from about 50 million cells to a billion cells in a week," Taylor said. "But we need 40 billion or 50 billion or 100 billion, so part of our science over the last few years has been scaling up the number of cells we can grow."

Another issue: Each heart needed a pristine environment free of contaminants for each step of the process. Every time an intervention had to be done, she and her team ran the risk of opening the heart up to infection -- and death.

"Do you know how long it takes to inject 350 billion cells by hand?" Taylor asked the Life Itself audience. "What if you touch something? You just contaminated the whole heart."

Once her lab suffered an electrical malfunction and all of the hearts died. Taylor and her team were nearly inconsolable.

"When something happens to one of these hearts, it's devastating to all of us," Taylor said. "And this is going to sound weird coming from a scientist, but I had to learn to bolster my own heart emotionally, mentally, spiritually and physically to get through this process."

Enter BAB, short for BioAssemblyBot, and an "uber-sterile" cradle created by Advance Solutions that could hold the heart and transport it between each step of the process while preserving a germ-free environment. Taylor has now taught BAB the specific process of injecting the cells she has painstakingly developed over the last decade.

"When Dr. Taylor is injecting cells, it has taken her years to figure out where to inject, how much pressure to put on the syringe, and the best speed and pace to add the cells," said BAB's creator Golway.

"A robot can do that quickly and precisely. And as we know, no two hearts are the same, so BAB can use ultrasound to see inside the vascular pathway of that specific heart, where Dr. Taylor is working blind, so to speak," Golway added. "It's exhilarating to watch -- there are times where the hair on the back of my neck literally stands up."

Taylor left academia in 2020 and is currently working with private investors to bring her creation to the masses. If transplants into humans in upcoming clinical trials are successful, Taylor's personalized hybrid hearts could be used to save thousands of lives around the world.

In the US alone, some 3,500 people were on the heart transplant waiting list in 2021.

"That's not counting the people who never make it on the list, due to their age or heath," Taylor said. "If you're a small woman, if you're an underrepresented minority, if you're a child, the chances of getting an organ that matches your body are low.

If you do get a heart, many people get sick or otherwise lose their new heart within a decade. We can reduce cost, we can increase access, and we can decrease side effects. It's a win-win-win."

Taylor can even envision a day when people bank their own stem cells at a young age, taking them out of storage when needed to grow a heart -- and one day even a lung, liver or kidney.

"Say they have heart disease in their family," she said. "We can plan ahead: Grow their cells to the numbers we need and freeze them, then when they are diagnosed with heart failure pull a scaffold off the shelf and build the heart within two months.

"I'm just humbled and privileged to do this work, and proud of where we are," she added. "The technology is ready. I hope everyone is going to be along with us for the ride because this is game-changing."

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'Ghost heart': Built from the scaffolding of a pig and the patient's cells, this cardiac breakthrough may soon be ready for transplant into humans -...

Global Live Cell Imaging Market to be Driven by Growing Stem Cell Research Market in the Forecast Period of 2022-2027 mbu timeline – mbu timeline

By Stell Cell Research

The new report by Expert Market Research titled, Global Live Cell Imaging Market Report and Forecast 2022-2027, gives an in-depth analysis of the global live cell imaging market, assessing the market based on its segments like product type, application, technology, and major regions. The report tracks the latest trends in the industry and studies their impact on the overall market. It also assesses the market dynamics, covering the key demand and price indicators, along with analysing the market based on the SWOT and Porters Five Forces models.

Request a free sample copy in PDF or view the report [emailprotected] https://bit.ly/3mtMGEU

The key highlights of the report include:

Market Overview (2017-2027)

As the number of stem cell research projects grows, so does the use of live cell imaging tools to analyse the location, purity, and amount of cells and their components, boosting market growth. The use of live cell imaging tools to precisely detect protein levels for optimal medication therapy is rising, as it is critical to determine the interaction between stem cells and tissues during stem cell research. The introduction of numerous government initiatives to support research and development (R&D) activities is fueling the live cell imaging industrys expansion. For example, in March 2020, the Canadian government announced a $6.9 million investment to promote stem cell research efforts in the country through the Stem Cell Networks research financing programme.

Furthermore, the increasing use of live cell imaging in the discovery of new medications is propelling the market forward. The development of new technologies that allow for the precise analysis of RNA, nucleic acid, proteins, and DNA, among other things, is driving demand for many diagnostic methods, moving the market forward. Furthermore, the rise in the prevalence of chronic diseases like cancer is driving up demand for live cell imaging in both diagnosis and treatment. The expanding research and development (R&D) activities to detect cancer cells in bone marrow while also allowing for the identification of specific cancer cells are likely to boost market growth.

Industry Definition and Major Segments

The study of living cells using microscope technology to obtain images of live cells and tissues is known as live cell imaging. It is essential in a variety of laboratory operations in biological and biomedical research because it gives real-time and reliable information on cells and tissues, making it suitable for stem cell research and regenerative medicine development.

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By technology, the market can be divided into:

The market can be categorised based on its applications into:

The major product types of live cell imaging are:

The regional markets include:

Market Trends

Artificial intelligence (AI), deep learning, and 3D printing are progressively being integrated into live cell imaging techniques, as technology improvements are a key antecedent of scientific research and development efforts. The expanding use of artificial intelligence (AI) allows for more precise, simpler, and time-efficient cell imaging. Furthermore, AI-based microscopy can recognise and analyse minor cell components like nuclei, allowing researchers to analyse data more quickly and effectively. AI-based microscopes also automate and optimise many functions for quantifying live cells, resulting in increased cell viability and faster image capture. This is fueling the expansion of the live cell imaging sector by increasing demand for such microscopes in research centres.

Furthermore, the increasing use of 3D printing in a variety of medical and biological applications is fueling market expansion. Because air bubbles are a common problem in perfusion chambers used in live cell imaging, the demand for fluidic devices made with 3D printing technology is increasing dramatically. Furthermore, the cost-effectiveness of 3D printing is increasing the affordability of live cell imaging research operations, which is propelling the market forward. In the forecast future, the development of portable and low-profile devices that can be directly installed on optical microscopes to improve cell imaging precision is expected to drive market expansion for live cell imaging.

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Key Market Players

The major players in the market are Carl Zeiss AG, Leica Microsystems GmbH, Nikon Instruments Inc., Becton, Dickinson and Company, GE Healthcare and Others.

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Global Live Cell Imaging Market to be Driven by Growing Stem Cell Research Market in the Forecast Period of 2022-2027 mbu timeline - mbu timeline

Stem Cells Market to Cross US$ 25.68 Bn by 2028, Increasing Demand for Stem Cells in Regenerative Medicines Accelerates Market Growth – BioSpace

By Stell Cell Research

Wilmington, Delaware, United States:

According to the report, the global stem cells market was valued at US$ 11.73 Bn in 2020 and is projected to expand at a CAGR of 10.4% from 2021 to 2028. Stem cells are defined as specialized cells of the human body that can develop into various different kinds of cells. Stem cells can form muscle cells, brain cells and all other cells in the body. Stem cells are used to treat various illnesses in the body.

North America was the largest market for stem cells in 2020. The region dominated the global market due to substantial investments in the field, impressive economic growth, increase in incidence of target chronic diseases, and technological progress. Moreover, technological advancements, increase in access to healthcare services, and entry of new manufacturers are the other factors likely to fuel the growth of the market in North America during the forecast period.

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Asia Pacific is projected to be a highly lucrative market for stem cells during the forecast period. The market in the region is anticipated to expand at a high CAGR during the forecast period. High per capita income has increased the consumption of diagnostic and therapy products in the region. Rapid expansion of the market in the region can be attributed to numerous government initiatives undertaken to improve the health care infrastructure. The market in Asia Pacific is estimated to expand rapidly compared to other regions due to shift in base of pharmaceutical companies and clinical research industries from developed to developing regions such as China and India. Moreover, changing lifestyles and increase in urbanization in these countries have led to a gradual escalation in the incidence of lifestyle-related diseases such as cancer, diabetes, and heart diseases.

Technological Advancements to Drive Market

Several companies are developing new approaches to culturing or utilizing stem cells for various applications. Stem cell technology is a rapidly developing field that combines the efforts of cell biologists, geneticists, and clinicians, and offers hope of effective treatment for various malignant and non-malignant diseases. The stem cell technology is progressing as a result of multidisciplinary effort, and advances in this technology have stimulated a rapid growth in the understanding of embryonic and postnatal neural development.

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Adult Stem Cells Segment to Dominate Global Market

In terms of product type, the global stem cells market has been classified into adult stem cells, human embryonic stem cells, and induced pluripotent stem cells. The adult stem cells segment accounted for leading share of the global market in 2020. The capability of adult stem cells to generate a large number of specialized cells lowers the risk of rejection and enables repair of damaged tissues.

Autologous Segment to Lead Market

Based on source, the global stem cells market has been bifurcated into autologous and allogenic. The autologous segment accounted for leading share of the global market in 2020. Autologous stem cells are used from ones own body to replace damaged bone marrow and hence it is safer and is commonly being practiced.

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Regenerative Medicines to be Highly Lucrative

In terms of application, the global stem cells market has been categorized into regenerative medicines (neurology, oncology, cardiology, and others) and drug discovery & development. The regenerative medicines segment accounted for major share of the global market in 2020, as regenerative medicine is a stem cell therapy and the medicines are made using stem cells in order to repair an injured tissue. Increase in the number of cardiac diseases and other health conditions drive the segment.

Therapeutics Companies Emerge as Major End-users

Based on end-user, the global stem cells market has been divided into therapeutics companies, cell & tissue banks, tools & reagents companies, and service companies. The therapeutics companies segment dominated the global stem cells market in 2020. The segment is driven by increase in usage of stem cells to treat various illnesses in the body. Therapeutic companies are increasing the utilization of stem cells for providing various therapies. However, the cell & tissue banks segment is projected to expand at a high CAGR during the forecast period. Increase in number of banks that carry out research on stem cells required for tissue & cell growth and elaborative use of stem cells to grow various cells & tissues can be attributed to the growth of the segment.

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Regional Analysis

In terms of region, the global stem cells market has been segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America dominated the global stem cells market in 2020, followed by Europe. Emerging markets in Asia Pacific hold immense growth potential due to increase in income levels in emerging markets such as India and China leading to a rise in healthcare spending.

Competition Landscape

The global stem cells market is fragmented in terms of number of players. Key players in the global market include STEMCELL Technologies, Inc., Astellas Pharma, Inc., Cellular Engineering Technologies, Inc., BioTime, Inc., Takara Bio, Inc., U.S. Stem Cell, Inc., BrainStorm Cell Therapeutics, Inc., Cytori Therapeutics, Inc., Osiris Therapeutics, Inc., and Caladrius Biosciences, Inc.

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Stem Cells Market to Cross US$ 25.68 Bn by 2028, Increasing Demand for Stem Cells in Regenerative Medicines Accelerates Market Growth - BioSpace

3D Cell Culture Market to reach 6.47 billion in 2030 with a CAGR of around 16.3% – GlobeNewswire

By Stell Cell Research

New York, United States, June 07, 2022 (GLOBE NEWSWIRE) -- 3D cell culture is regarded as an artificially created environment where the biological cells are allowed to grow or interact with their respective surroundings in all three dimensions. In terms of technology,scaffold-based technologyhad thelargest revenue share of more than about 68.96 % in 2020 and it is estimated to maintain its dominance all over the forecasted period of 2020-2030. Moreover, on a regional basis, North America dominated the total 3D Cell Culture Market in 2020, possessing a revenue share of more than 43 %. However, the APAC region is prevised to witness the fastest CAGR within the regional market from 2020 to 2030.

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The segmentation outlook of the latest report published by Strategic Market Research on3D Cell Culture Market is as follows:

Based on Technology

Based on Application

Based on End-User

Regions

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The 3D Cell Culture Market is poised to reach a market value of USD 6.47 billion by 2030 from USD 1.43 billion in 2020, at a CAGR of 16.3 % during the forecasted period. Growth in this 3D Cell Culture market is primarily driven by the rise in the focus on new upcoming alternatives for animal testing, increase in the focus on personalized medicine, growing occurence of chronic diseases, and the wide availability of funding for the research purposes. The high utility of 3D models for research purposes about Covid-19 as well as respiratory diseases is prevised to provide massive growth opportunities to the 3D Cell Culture market. Several other vital parameters amplifying the market growth include the introduction of new products and the broad applications of 3D protocols in the field of biological researches.

By Technology, the scaffold-based technologysegment held the largest share of the 3D Cell Culture Market.

In terms of technology,scaffold-based technologyhad thelargest revenue share of more than 68.96 % in 2020.Furthermore, surge in the demand for scaffold-based technology and the rise in the awareness of nanotechnology in the field of biomedical research and its vast applications is prevised to provide ample opportunities for the growth of the segment. The National Institutes of Health declared an investment of around USD 445 Million in nanomedicine in the year 2020. In addition, the National Nanotechnology Initiative got more than USD 1.7 Billionin funding in the year 2021, which in turn will foster the expansion of the 3D cell culture scaffold market.

By Application, the Cancer segment possessed the highest share of the 3D Cell Culture Market.

In terms of Application, the Cancer market segment possessed the maximum portion of the total 3D Cell Culture Market share, accounting for about 24.56 % of the total market revenue, and is previse to expand at a CAGR of 15.4 % in 2020. Growing R&D activities by utilizing spheroids as model systems to create anti-cancer treatments and the rise in the usage of 3-dimensional cellular models are the key drivers that are amplifying the growth of this market segment. As per The National Cancer Institute, it is reported that there were 16.9 million cancer survivors in USA in the year 2020, and by the end of the year 2030, the total number of cancer survivors is projected to reach a landmark of 22.2 million. Furthermore, from 2021 to 2030, the stem cell research market segment is prevised to expand at the fastest CAGR throughout the forecasted timeframe.

By End-User, the Biotechnology and Pharmaceutical industries dominated the entire 3D Cell Culture Market.

In terms of End-user, the entire market is segregated into Biotechnology & Pharmaceutical Industries, Research Laboratories and Institutes, Hospitals and Diagnostic Centers, and Others. Among these segments, the biotechnology and pharmaceutical industries category held the largest revenue share of more than 46% in the year 2020. In comparison to 2D cell culture, the 3D cell culture possesses a wide variety of benefits and advantages in terms of supplying appropriate oxygen content and nutritional gradients and helps to better understand various cell functions like adhesion, proliferation, morphology, viability, microenvironment, and response to drugs. These are some of the key factors that are driving the segments growth.

North America held a significant portion of the 3D Cell Culture Market share.

By Region, North America dominated the total 3D Cell Culture Market in 2020, possessing a revenue share of more than 43 %. It is also anticipated that the North American region will maintain its dominance throughout the projected period due to the factors like rise in the private and state financial support for building advanced 3D cell culture models, rise in the healthcare expenditures, and the growing number of research institutes and universities. For example, Inventia Life Science, a global leader in advanced 3D cell culture for clinical and research purposes, has declared the closure of a USD 25 Million Series B funding round which was led by Blackbird Ventures. On the other hand, the APAC/Asia- Pacific region is prevised to witness the fastest CAGR within the regional market from 2021 to 2030. It is primarily due to the rising investments by various multinational corporations in the entire region.

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Pertinent players that are covered in the Global 3D Cell Culture Market report are:

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3D Cell Culture Market to reach 6.47 billion in 2030 with a CAGR of around 16.3% - GlobeNewswire

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