Stem Cell Clinic

Selma Blair Posts Nude Diving Photo After MS Stem Cell …

Kids do the darndest things to their parents, and thats apparently true whether you have a chronic illness or not.

Selma Blair just shared a photo on Instagram of herself executing a perfect dive. At first, its like whoa, Selma has amazing form! but then you realize you can totally see her bare butt. Sotheres a backstory to this.

On Wednesday, Selma (who has multiple sclerosis) shared a photo of herself on Instagram preparing to dive into a pool. Given that Selma uses a cane to walk and has mobility issues, this was kind of a BFD. Well, just as Selma prepared to take the plunge, her 8-year-old son Arthur came out of nowhere and pushed her in, leaving Selma flailing as she fell.

Preparing to dive. A very big deal for me, she wrote in the caption. "Instead, I felt a tiny hand on swimsuit and lost any coordination. Her hashtags were hilarious: #terror #punkkid #payback is coming.

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Fast-forward to that gorgeous dive pic Victory. I dont give up. #bottomsup my boy is a #crackup@kidarthursaint, Selma wrote in the caption.

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Selma, who was diagnosed with MS more than a year ago, has been very candid with fans about her mobility issues. She often uses a cane for balance and occasionally uses an Alinker walking bike to help her get around.

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Selma recently revealed that she had been away from home for months to undergo treatment for her MS. One fan asked in the comments what differences she's noticed after having stem cell treatment, and she responded with this: "I can dive!"

Selma, FTW!

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Selma Blair Posts Nude Diving Photo After MS Stem Cell ...

How The Overlap Between Artificial Intelligence And Stem Cell Research Is Producing Exciting Results – Forbes

Passage Of California Stem Cell Proposition Boosts Research

For the last decade and more, Stem Cell research and regenerative medicine have been the rave of the healthcare industry, a delicate area that has seen steady advancements over the last few years.

The promise of regenerative medicine is simple but profound that one day medical experts will be able to diagnose a problem, remove some of our body cells called stem cells and use them to grow a cure for our ailment. Using our body cells will create a highly personalized therapy attuned to our genes and systems.

The terminologies often used in this field of medicine can get a bit fuzzy for the uninitiated, so in this article, I have relied heavily on the insights of Christian Drapeau, a neurophysiologist and stem cell expert.

Drapeau was one of the first voices who discovered and began to speak about stem cells being the bodys repair system in the early 2000s. Since then, he has gone on to discover the first stem cell mobilizer, and his studies and research delivered the proof of concept that the AFA (Aphanizomenon flos-aquae) extract was capable of enhancing repair from muscle injury.

Christian Drapeau is also the founder of Kalyagen, astem cell research-based company, and the manufacturers of Stemregen. This stem cell mobilizer combines some of the most effective stem cell mobilizers Drapeau has discovered to create an effective treatment for varying diseases.

How exactly do stem cell-based treatments work? And how is it delivering on its promise of boosting our abilities to regenerate or self-heal?

Drapeau explains the concept for us;

Stem cells are mother cells or blank cells produced by the bone marrow. As they are released from the bone marrow stem cells can travel to any organ and tissue of the body, where they can transform into cells of that tissue.Stem cells constitute the repair system of the body.

The discovery of this function has led scientists on a long journey to discover how to use stem cells to cure diseases, which are essentially caused by cellular loss. Diseases like Diabetes and age-related degenerative diseases are all associated with the loss of a type of cell or cellular function.

However, what Drapeaus research has unearthed over the last few decades is that there are naturally occurring substances that show a demonstrated ability to induce the release of stem cells from the bone marrow. These stem cells then enter the bloodstream, from where they can travel to sites of cell deficiency or injury in the body to aid healing and regeneration. This process is referred to as Endogenous Stem Cell Mobilization (ESCM).

Stemregen is our most potent creation so far, explains Drapeau, and it has shown excellent results with the treatment of problems in the endocrine system, muscles, kidneys, respiratory systems, and even with issues of erectile dysfunction.

Despite the stunning advancements that have been made so far, a concern that both Drapeau and I share is how this innovation can be merged with another exciting innovation; AI.

Is it even a possibility? Drapeau, an AI enthusiast, explains that AI has already been a life-saver in stem cell research and has even more potential.

On closer observation, there are a few areas in which AI has greatly benefited stem cell research and regenerative medicine.

One obstacle that scientists have consistently faced with delivering the full promise of regenerative medicine is the complexity of the available data.Cells are so different from each other that scientists can struggle with predicting what the cells will do in any given therapeutic scenario. Scientists are faced with millions of ways that medical therapy could go wrong.

Most AI experts believe that in almost any field, AI can provide a solution whenever there is a problem with data analysis and predictive analysis.

Carl Simon, a biologist at the National Institute of Standards and Technology (NIST) and Nicholas Schaub recentlytested this hypothesiswhen they applied Deep Neural Networks (DNN), an AI program to the data they had collected in their experiments on eye cells. Their research revolved around causes and solutions for age-related eye degeneration. The results were stunning; the AI made only one incorrect prediction about cell changes out of 36 predictions it was asked to make.

Their program learned how to predict cell function in different scenarios and settings from annotated images of cells. It soon could rapidly analyze images of the lab-grown eye tissues to classify the tissues as good or bad. This discovery has raised optimism in the stem cell research space.

Drapeau explains why this is so exciting;

When we talk about stem cells in general, we say stem cells as if they were all one thing, but there are many different types of stem cells.For example, hair follicle and dental pulp stem cells contain neuronal markers and can easily transform into neurons to repair the brain. Furthermore, the tissue undergoing repair must signal to attract stem cells and must secrete compounds to stimulate stem cell function. A complex analysis of the tissue that needs repair and the conditions of that tissue using AI, in any specific individual, will help select the right type of stem cells and the best cells in that stem cell population, along with the accompanying treatment to optimize stem cell-based tissue repair.

Christian Drapeau

Ina study published in Februaryof this year inStem Cells, researchers from Tokyo Medical and Dental University (TMDU) reported that their AI system, called DeepACT, had successfully identified healthy, productive skin stem cells with the same accuracy that a human could. This discovery further strengthens Drapeaus argument on the potentials of AI in this field.

This experiment owes its success to AIs machine learning capabilities, but it is expected that Deep Learning can be beneficially introduced into regenerative medicine.There are many futuristic projections for these possibilities, but many of them are not as far-fetched as they may first seem.

Researchers believe that AI can help fast-track the translation of regenerative medicine into clinical practice; the technology can be used to predict cell behavior in different environments. Therefore, hypothetically, it can be used to simulate the human environment. This means that researchers can gain in-depth information more rapidly.

Perhaps the most daring expectation is the possibility of using AI to pioneer the 3D printing of organs. In a world where organ shortage is a harsh reality, this would certainly come in handy. AI algorithms can be utilized to identify the best materials for artificial organs, understand the anatomic challenges during treatment, and design the organ.

Can stem cells actually be used along with other biological materials to grow functional 3D-printed organs? If this is possible, then pacemakers will soon give way to 3D-printed hearts. A 3D-printedheart valvehas already become a reality in India, making this even more of an imminent possibility.

While all of these possibilities excite Drapeau, he is confident that AIs capabilities with data analysis and prediction, which is already largely in use, would go down as its most beneficial contribution to stem cell research;

It was already shown that stem cells laid on the connective tissue of the heart, the soft skeleton of the heart, can lead the entire formation of a new heart. Stem cells have this enormous regenerative potential. AI can take this to another level by helping establish the conditions in which this type of regeneration can be orchestrated inside the body.But we have to be grateful for what we already have, over the last 20 years, I have studied endogenous stem cell mobilization and today the fact that we have such amazing results with Stemregen is testament that regenerative medicine is already a success.

As AI continues to scale over industry boundaries, we can only sit back and hope it delivers on its full potential promise. Who knows? Perhaps AI really can change the world.

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How The Overlap Between Artificial Intelligence And Stem Cell Research Is Producing Exciting Results - Forbes

Stem cell therapy for heart failure lowers risk of adverse outcomes – Cardiovascular Business

Stem cell therapy can help heart failure (HF) patients decrease their risk of a non-fatal myocardial infarction (MI) or stroke, according to new research presented at the American Heart Associations Scientific Sessions 2021.

Researchers tracked data from 537 patients with heart failure withreduced ejection fraction (HFrEF).Eighty percent of the patients were men, and the median age was 63 years old.

Patients were split into two groups: 261 patients were injected with 150 million mesenchymal precursor cells [stem cells] provided by healthy donors directly into the heart using a catheter, and 276 patients underwent a fake procedure.

According to the authors, patients were discharged from the hospital the day after the procedure and were followed for an average of 30 months.

Overall, the team associated stem cell use with a 65% decrease in non-fatal MIs and stroke events. Also,patients with high levels of inflammation (CRP levels of at least 2 mg/L) were 79% less likely to have non-fatal MI or stroke after being given stem cells.

Moreover, stem cell treatment lowered cardiac death by 80% in patients with high levels of inflammation and less severe HF.

However, the team added, there was no reduction in hospitalizations for HF among patients who received stem cells.

Cell therapy has the potential to change how we treat HF, lead author Emerson C. Perin, MD, PhD, director of the Center for Clinical Research and medical director of the Texas Heart Institute in Houston, said in a prepared statement. This study addresses the inflammatory aspects of HF, which go mostly untreated, despite significant pharmaceutical and device therapy development. Our findings indicate stem cell therapy may be considered for use in addition to standard guideline therapies.

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Stem cell therapy for heart failure lowers risk of adverse outcomes - Cardiovascular Business

A second HIV patient may have been ‘cured’ of infection without stem cell treatment, in extremely rare case – CNN

The patient has received no regular treatment for her infection but is a rare "elite controller" of the virus who, eight years after she was first diagnosed, shows no signs of active infection and shows no signs of intact virus in her body, researchers reported Monday. This has only been reported once before.

The 30-year-old woman in the new study is only the second patient who has been described as achieving this sterilizing cure without help from stem cell transplantation or other treatment. The other patient who has been described as achieving this was a 67-year-old woman named Loreen Willenberg.

"A sterilizing cure for HIV has previously only been observed in two patients who received a highly toxic bone marrow transplant. Our study shows that such a cure can also be reached during natural infection -- in the absence of bone marrow transplants (or any type of treatment at all)," Dr. Xu Yu, of the Ragon Institute of Massachusetts General Hospital, MIT and Harvard, who was an author of the study, wrote in an email to CNN on Monday.

"Examples of such a cure that develops naturally suggest that current efforts to find a cure for HIV infection are not elusive, and that the prospects of getting to an 'AIDS-free generation' may ultimately be successful," Yu wrote.

Yu, Dr. Natalia Laufer in Argentina, and their colleagues analyzed blood samples collected from the 30-year-old HIV patient between 2017 and 2020. She had a baby in March 2020, allowing scientists to collect placental tissue, as well.

The patient was first diagnosed with HIV in March 2013. She started no antiretroviral treatment until 2019, when she became pregnant and began treatment with the drugs tenofovir, emtricitabine, and raltegravir for six months during her second and third trimesters, the researchers noted. After delivering a healthy HIV-negative baby, she stopped the therapy.

An analysis of billions of cells in her blood and tissue samples showed that she had been infected with HIV before but, during the analysis, the researchers found no intact virus that was capable of replicating. All they could find were seven defective proviruses -- a form of a virus that is integrated into the genetic material of a host cell as part of the replication cycle.

The researchers are not sure how the patient's body was able to apparently rid itself of intact, replication-competent virus but, "we think it's a combination of different immune mechanisms -- cytotoxic T cells are likely involved, innate immune mechanism may also have contributed," Yu wrote in her email.

"Expanding the numbers of individuals with possible sterilizing cure status would facilitate our discovery of the immune factors that lead to this sterilizing cure in broader population of HIV infected individuals."

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A second HIV patient may have been 'cured' of infection without stem cell treatment, in extremely rare case - CNN

Stem Cell Therapy Reduces Need for Nearly 10% of Hip Replacements – Yale School of Medicine

Daniel Wiznia, MD, an orthopaedic surgeon with Yale School of Medicine, is practicing a surgical technique designed to render 10% of hip replacements unnecessary. Regenerative properties from a patients own stem cells are responsible for regrowing bone, restoring blood flow, and being able to avoid further interventional surgery.

Osteonecrosis, also known as avascular necrosis, occurs in more than 20,000 Americans each year. As the condition progresses, bone cells known as osteoblasts become unable to repair themselves and sustain the integrity of the bone, and ultimately die. The bone deterioration leads to a decrease in blood flow to the area, further weakening the entire skeletal structure of the upper leg. If unaddressed, the ball portion of the hips ball and socket joint will cave in on itself and collapse, requiring a total hip replacement.

The fact that patients often receive this diagnosis during their 30s and 40s presents a particular challenge. While the lifespan of hip prosthetics has dramatically increased in recent years, a patient who undergoes a total hip arthroplasty, or total hip replacement, at that age will almost certainly require a revision later in life. This redo of the same surgery at an older age comes with an entirely new set of risks and potential complications, making it that much harder to manage down the road.

The goal in patients with this condition then becomes very clear: prevent the head of the femur (thighbone) from collapsing.

Wiznia, assistant professor of orthopaedics and rehabilitation, and of mechanical engineering and materials science, draws from both of those areas of expertise to use 3D imaging technology as part of an innovative joint-preservation procedure. In recent years, he has worked closely with the Yale School of Engineering & Applied Sciences and the Integrated 3D Surgical Team at the Yale School of Medicine to tailor this treatment to each patient. Imaging has proven to be critical to the successful outcome of this surgical technique.

One of the challenges of orthopaedic surgery in the human body is that surgeons are operating in a three-dimensional space and are often reliant on two-dimensional imagery such as X-rays, Wiznia says. Through computer modeling, we are able to customize those images and create models that are specific to each patient, which, in turn, enhances outcomes and overall post-operative success rates.

Wiznia surgically harvests bone marrow from the patients pelvis. By using a centrifuge inside the operating room, he is able to isolate and concentrate the individuals own stem cells. Material containing the stem cells is then injected into the area of bone that has died.

Research has shown that stem cells possess the characteristics and qualities needed for the body to regrow, repair, and regenerate damaged tissue and bone, and according to Wiznia, this treatment dramatically reduces the risk of the head of the femur from collapsing. Soon after the procedure, many patients with avascular necrosis experience rejuvenated blood supply to the area and the bone is repopulated with new cells. This can additionally alleviate the short-term need for a hip replacement.

The major challenge in this patient population is identifying, diagnosing, and performing surgical intervention in time before the collapse. Because the vascular injury is usually a painless event, says Wiznia, patients are generally unaware of the specific point in time when the injury occurred, which is why cases are rarely discovered in time.

Patients may be encouraged to know that those who have avascular necrosis of the hip generally have it present on both sides, and it can develop on the two sides at different rates. So, even if it is detected too late on one side, there is still a chance to preserve the other.

We usually are able to catch that second asymptomatic side in those situations and conduct the core decompression with stem cell treatment before it collapses, Wiznia says. This novel stem cell therapy has demonstrated improved pain and function, and the stem cells decrease the risk of the femoral head from collapsing. That ultimately translates into fewer young patients requiring hip replacements along with subsequent surgeries in their later years.

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Stem Cell Therapy Reduces Need for Nearly 10% of Hip Replacements - Yale School of Medicine

The Promise of Stem Cells to Help Children with Autism – Entrepreneur

Opinions expressed by Entrepreneur contributors are their own.

I take great pleasure meeting many patients we help recover from serious injuries and ease symptoms of debilitating diseases so they can improve their lives through advanced stem cell therapy. In some cases, these patients report that after treatment they feel more energy a sense of vitality they enjoyed in their youth.

But what about patients who are young children some facing a future so uncertain that they may never even learn to talk, let alone enjoy a long rewarding life.

Thats the pain all too many parents cope with when their children are diagnosed with autism, or more specifically, autistic spectrum disorder (ASD). This spectrum of neurological conditions is seen in young children who dont seem to develop normalsocial, communication and behavioral skills.

Thats a vague description, I know, but that makes a diagnosis of ASD even more frustrating. Some children may function relatively well, but not make friends easily or demonstrate odd speech patterns. Others may not even be able to make eye contact or communicate at all, making the idea of going to school, let alone graduate and lead an independent life, seem impossible. Its not a rare condition, either. According to the U.S. Centers for Disease Control, ASD now affects about 1 out of 54 children in the United States.

Research shows that the earliertreatment can begin, the better. And the evidence is growing that stem cell therapy can help alleviate the symptoms for many children who suffer from ASD. Thats why Im so pleased that our advanced stem cell therapies can help more children who suffer from ASD enjoy a much brighter future.

Related:This 37-Year-Old Entrepreneur Is UntanglingAutisticMinds With ...

Current therapies for autism mostly include medications such as SSRIs, anxiolyticsand mood stabilizers. Although medications may decrease intensity and frequency of symptoms, they do not address the root causes of autistic disorders, which research shows can result from oxygen deprivation and intestinal inflammation.

The rationale behind treating autism with stem cells is that autism, and its degree of severity, has been significantly correlated to inflammatory and neuro-inflammatory cytokines. Intravenous administration of umbilical cord-derived stem cells has been shown in multiple clinical trials to reduce inflammation. Reducing inflammation in the autistic patient may alleviate symptoms of autism.

Heres one heartwarming story that reveals how stem cells offer new hope to parents of children with ASD. Back in June at age 19, Kenneth graduated from high school.

That may not seem like much of an accomplishment, but Kenneth was diagnosed with ASD at age two. When he was eightyears old, his parents say he was still in diapers and struggled to even communicate, but thats when he started receiving stem cell treatments.

His parents report that stem cells made a big difference. His mother, Marty Kelley, noted improvement within days of his first treatment. And his father Donald Kelley said, when you see that your child has been blessed with stem cell treatments and the improvement, its just a dream come true.

No, its not just a dream. Its based on science and research into how the body tries to heal itself naturally using stem cells.

As Kenneth says about the treatments, they put a little needle in, its not too bad. Thats a keen observation on another aspect of stem cell therapy that its a non-invasive procedure that poses little risk of side effects.

Related:This Is HowStem-Cell TherapyTreats Serious Brain Injuries

Although scientists arent sure exactly what causes ASD, our Chief Medical Officer Karolynn Halpert points out that these disorders are associated with the process of how the body modulates immune response and controls inflammation, but that stem cells have the ability to communicate with the immune system and release anti-inflammatory factors that can help reduce brain inflammation (neuroinflammation).

Dr. Halpert also explains that inflammation in the digestive system can also interfere with neurological function. Indeed, that phrase, gut feeling,isnt just an expression. Researchers have confirmed that the gut and the brain are linked in a gut-brain axisthat creates complex interactions in neurological functioning in ways that are not fully understood.

Some research suggests that autistic spectrum disorders may cause a heightened level of inflammation throughout the gastrointestinal tract, which can aggravate symptoms. There is significant evidence, however, that inflammation is controlled by stem cells. Thats why it helps promote healing and ease pain for patients we treat for a wide range of injuries such as TBI, and diseases such as autoimmune disorders, degenerative disc disease and many others all that can cause too much harmful inflammation.

Related:Researching the Safety and Effectiveness ofStem Cellsto Treat ...

As Dr. Halpert points out, stem cells help other cells signal each other more effectively replacing cells in the digestive system and throughout the body to balance immune response and control inflammation to potentially help children with autistic symptoms improve thinking and cognitive function.

Thats good news for ASD patients and their parents, especially with advanced stem cell therapy now available using ourproprietary protocols to culture the most potent cells. These cells are harvested from donated umbilical cords, which are rich in a specific type of stem cell mesenchymal stem cells. These cells are then screened for specific biomarkers that indicate high potency. Only cells that meet the criteria for high levels of potency are then reproduced into infusions that are given to patients a non-invasive therapy thats like Kenneth describes just a little needle.

As autistic spectrum disorder cases become more commonly diagnosed in children at younger ages, its essential to identify these cases early so treatment can begin as soon as possible. Its clear that the earlier treatment begins, the more likely it is that these children can enjoy better lives in the years ahead.

So congratulations Kenneth on your recent graduation. You earned your diploma. Your parents are proud of you. I am, as well. You and other ASD patients are an inspiration for our entire team to help others like you not only graduate from school but live a life filled with as much joy as possible.

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The Promise of Stem Cells to Help Children with Autism - Entrepreneur

Global Cell Therapy Manufacturing Market Competition Forecast & Opportunities to 2026 – ResearchAndMarkets.com – Galveston County Daily News

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Global Cell Therapy Manufacturing Market Competition Forecast & Opportunities to 2026 - ResearchAndMarkets.com - Galveston County Daily News

Dr Pengyi Yang wins National Stem Cell Foundation Metcalf Prize – News – The University of Sydney

Dr Pengyi Yang uses computational expertise to build virtual cells.

DrPengyiYanghasreceived one of two annual $55,000 Metcalf Prizes from the National Stem Cell Foundation of Australia inrecognition of his leadership in the field.

DrYangholds a joint position with the University of SydneySchool of Mathematics & Statistics, theCharles Perkins Centreand theChildren's MedicalResearch Institute. His work aims toremove much of the guesswork from stemcell science and eventually stemcell medicine.

Todays stem cell treatmentshave beenthe product of trial anderror, DrYang said.

My virtual stem cell will allow us to understand whats happening inside a single stem cell that makes it decide what type of cell it will becomesuch as, but not limited to,hair, skin, muscle, nerveorbloodcells.

He is mapping the many, complex influencescontrollingstem cells andthe waythey specialise into different cell types.

Stem cells are amazing because they can produce any kind of cell in the body. Theyre fundamental toregenerative medicine,DrYang said.

But, when theircontrols fail,rogue stem cells can lead to cancer.

Allhumanlifestartsas a single stem cell. It goes on to produce cells that eventually become every type of tissue and organ of the human body. Even in adulthood, stem cellsrepairandreplacetissue all the time.

People are excited about the potential of stem cell medicine, but thereality is extremely complicated. Thousands of genes, complex gene networks, environmental factors, and an individuals own health are all involved in pushing stem cells to become specific cell types,DrYang said.

DrYang, a computerscientist turned stem cell researcher, uses computational science and statistics to understand how stem cells function at a fundamental level work that will be useful forthe entire stem cell field ofresearch.

We need a computermodel to bring all of these influences togetherso we can identify the specific gene networks that drive the stem cells towards each cell type,he said.

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Dr Pengyi Yang wins National Stem Cell Foundation Metcalf Prize - News - The University of Sydney

BioRestorative Therapies Enters into Letter of Intent with PRC Clinical – BioSpace

PRC Clinical to Provide Start-up CRO Services for BRTX-100 Phase 2 Clinical Trial

MELVILLE, N.Y., Nov. 19, 2021 (GLOBE NEWSWIRE) -- BioRestorative Therapies, Inc. (the Company" or BioRestorative) (NASDAQ:BRTX), a life sciences company focused on adult stem cell-based therapies, today announced that it has entered into a letter of intent with PRC Clinical, a CRO specializing in clinical trial management, with regard to PRC Clinical providing startup clinical project management activities for the Companys BRTX-100 Phase 2 clinical trial to treat chronic lumbar disc disease.

We are pleased to announce that we have entered into a letter of intent for PRC Clinical to provide startup activities for our Phase 2 study. PRC has extensive experience and expertise in managing clinical studies in the stem cell and regenerative medicine space. They also have the experienced and professional network of clinicians and study sites streamlining patient enrollment, site monitoring and management. Additionally, we have been working with and familiarizing ourselves with PRCs team and capabilities since 2019. We are thrilled to finally be in a position to begin the process of validating our technology through the FDA process, while keeping shareholders updated along the regulatory pathway, said Lance Alstodt, CEO of BioRestorative.

PRC Clinical has provided specialty CRO services for nearly 20 years. Their innovative approach to executing studies for biotech and pharmaceutical companies combines high-touch human elements and cutting-edge technology with extensive experience and deep therapeutic knowledge. PRC Clinical is an all inclusive CRO and has specialized expertise across regenerative medicine, CNS, ophthalmology, pulmonary and COVID-19, rare and orphan disease and more complex indications.

PRC Clinical is pleased to begin start-up CRO activities for BRTX-100. We look forward to being able to bring our stem cell experience to this trial. We are committed to supporting BioRestoratives development of BRTX-100 and its clinical application, said Curtis Head, CEO of PRC Clinical.

About BioRestorative Therapies, Inc.

BioRestorative Therapies, Inc. (www.biorestorative.com) develops therapeutic products using cell and tissue protocols, primarily involving adult stem cells. Our two core programs, as described below, relate to the treatment of disc/spine disease and metabolic disorders:

Disc/Spine Program (brtxDISC): Our lead cell therapy candidate, BRTX-100, is a product formulated from autologous (or a persons own) cultured mesenchymal stem cells collected from the patients bone marrow. We intend that the product will be used for the non-surgical treatment of painful lumbosacral disc disorders or as a complementary therapeutic to a surgical procedure. The BRTX-100 production process utilizes proprietary technology and involves collecting a patients bone marrow, isolating and culturing stem cells from the bone marrow and cryopreserving the cells. In an outpatient procedure, BRTX-100 is to be injected by a physician into the patients damaged disc. The treatment is intended for patients whose pain has not been alleviated by non-invasive procedures and who potentially face the prospect of surgery. We have received authorization from the Food and Drug Administration to commence a Phase 2 clinical trial using BRTX-100 to treat chronic lower back pain arising from degenerative disc disease.

Metabolic Program (ThermoStem): We are developing a cell-based therapy candidate to target obesity and metabolic disorders using brown adipose (fat) derived stem cells to generate brown adipose tissue (BAT). BAT is intended to mimic naturally occurring brown adipose depots that regulate metabolic homeostasis in humans. Initial preclinical research indicates that increased amounts of brown fat in animals may be responsible for additional caloric burning as well as reduced glucose and lipid levels. Researchers have found that people with higher levels of brown fat may have a reduced risk for obesity and diabetes.

Forward-Looking Statements

This press release contains "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and such forward-looking statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause future circumstances, events or results to differ materially from those projected in the forward-looking statements as a result of various factors and other risks, including, without limitation, those set forth in the Company's latest Form 10-K filed with the Securities and Exchange Commission. You should consider these factors in evaluating the forward-looking statements included herein, and not place undue reliance on such statements. The forward-looking statements in this release are made as of the date hereof and the Company undertakes no obligation to update such statements.

CONTACT:

Email: ir@biorestorative.com

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BioRestorative Therapies Enters into Letter of Intent with PRC Clinical - BioSpace

SC21- 21st century cellular medicines specialists – The Thaiger

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Although stem cells are known to work wonders, there is still a lot of misunderstanding about what they are, what they do, and how they work.

The good news is that StemCells21 can clear everything up for you. SC21 produces all of its cellular medications in-house, and all of its treatments are performed at its cutting-edge medical centre in Bangkok. Its a one-stop shop that adheres to high-quality standards.

This company will be on display at the Thailand International Boat Show, which will be hosted at Royal Phuket Marina from January 6 to 9 next year. Staff from StemCells21 will be on hand to walk you through the producers, pricing, and techniques.

StemCells21s laboratory is a full-scale culture & analysis laboratory specialising in the production & treatment of Mesenchymal Stem Cells (StemCells21), and Natural Killer Cells (ImmuneCells21). It has also launched a new generation of regenerative medicine called Pluripotent Stem Cells (iPSC21), which hold great potential for impacting chronic diseases in the quest for anti-ageing.

The lab has seven scientists & stem cell researchers, a couple of who have worked with Professor Shinya Yamanaka, who was awarded the Nobel Prize in Physiology or Medicine in 2012 for the discovery that mature cells can be reprogrammed to become pluripotent (iPS cells).

Photo Via: Stemcells 21

Before StemCells21 was created, Managing Director Paul Collier and co-founder Sergei Dmitrievs experienced the power of stem cells either first hand or through the treatment of someone close to them. They knew that stem cells could deliver positive health results, and also knew stem cell treatmentsand the clinics that administered themhad room for improvement.

After deep laboratory investigation, they came to see that most clinics utilised relatively low-quality stem cells and incomplete treatments. While these clinics could deliver a certain level of positive results, they were only scratching the surface of the promise that stem cell treatments could deliver.

Furthermore, the clinics themselves frequently provided a less-than-ideal patient experience. Clinics were generally hectic, unprofessional, and unwelcoming. Patients were often administered a single treatment and sent on their way, unsure if they had experienced an efficacious treatment or if they had travelled and paid for nothing.

StemCells21 was created to offer superior results and give you a welcoming experience. It was set up to provide the global community with access to treatments that few people are aware of, and to offer health benefits that are superior to what most people ever imagined were possible.

The SC21 complex in Bangkok houses the StemCells21, ImmuneCells21, and IPS21 laboratories, as well as the premium 5* IntelliHealth+ (IH+) Clinic.

IntelliHealth+ is a state-of-the-art medical centre licensed by the Thai medical authorities. The luxurious design, efficient workflow layouts, and modern treatments make it the ideal choice for customers seeking a premium level of healthcare in 5* settings.

The centre treats patients from all over the world and has staff who speak fluent English, Arabic, Chinese, Russian, Thai and Spanish.

Furthermore, SC21s come from all corners of the globe for these cutting edge treatments. Many VIPs travel to the clinic including presidents, prime ministers, sports stars, football managers, bank owners and heads of major corporations, many of whom return every six to twelve months and have been doing so for years.

Recently, SC21 treated a ten-year-old British boy who had Ewing sarcoma develop in his arm, which then spread to other areas. He had tried every treatment option in the UK. His trip and treatment were sponsored by UK football teams and the public. Since he started treatment hes put on weight, hes vibrant, and his demeanour has totally changed. Various tests and scans have shown he is responding very well to the immunotherapy course and will perform another round in a few months time.

SC21 focuses on three main areas: anti-ageing and longevity; orthopaedic and muscular-skeletal issues (knee, hip, back & shoulder); and chronic diseases (diabetes, liver cirrhosis, lung, respiratory, hearing & vision disorders). Aside from that, the clinic can also help with chronic fatigue and burn-out syndrome.

Outpatient services for anti-ageing, immunotherapy and regenerative medicine are available at the centre. The anti-ageing clinic has a cutting-edge approach to skin rejuvenation, dermatology, detoxification, and wellbeing. A youthful appearance, more energy, improved mental capacity and mobility, reduced aches and pains, and a stronger immune system are among the benefits.

Photo Via: Stemcells 21

The high level of traditional medicine and the unique protocols designed by the IH+ teams give patients real therapeutic benefits and longevity.

According to Paul Collier, a client typically receives two sessions of stem cell injections during a treatment intravenous for systemic and local to the target and is required to stay in Bangkok for two days following their procedure to monitor any complications that may arise. Then theyre given a two-month take-home kit that comprises self-administered injections (similar to insulin) that target specific growth factors in organs or tissues that need to be repaired. These can also be taken orally, but they are less effective.

He goes on to say that stem cells are the foundation of the human body. They split over and over to produce humans from an embryo at the start of our lives. They restore cells in your blood, bone, skin, and organs throughout your life to keep you alive and functioning. Stem cells have two distinct properties that distinguish them from other types of cells in our bodies.

First, they can self-renew (mitosis), which is a stage of the cell cycle in which replicated chromosomes are divided into two new nuclei. As a result, identical duplicated cells are produced.

Secondly, they have the ability to differentiate into specialized cells such as cartilage, heart cells, liver cells, and neurons. No other cell in the body has the natural ability to generate new cell types.

Mesenchymal Stem Cells (MSCs) are at the core of StemCells21s regenerative programs. They are multipotent stem cells derived from various adult and fetal tissues. A large number of studies have shown the beneficial effects of MSC-based therapies to treat different pathologies, including neurological disorders, cardiac ischemia, diabetes, and bone and cartilage diseases.

StemCells21 also has arthritis treatment, which reduces inflammation & joint pain, increases cartilage growth, improves mobility & joint stability and lessens dependence on medication. The clinics degenerative spine treatments help discs regenerate and stabilize the spine.

On top of that, it provides lung & liver disease treatment as well as treatments for autism, cerebral palsy, diabetes, motor neuron disease, multiple sclerosis and immune disorders.

Theres even eye treatment, which reduces blurred vision & field of vision defects, improves night vision & enhances colour texture.

Photo Via: Stemcells 21

SC21 can even help with certain types of cancer by taking a clients blood and growing their natural killer cells (immunotherapy) over a 21-day period. Through various stimuli, their cytotoxicity is increased which kills cancer and virally-affected cells.

Paul says stem cell therapy should be looked at before undergoing any kind of invasive surgery. The type of medicine should certainly be an intervention before surgery. If you are looking at knee replacement, why not consider an injection of a biologic that would only take a couple of days and has the potential to remodel the cartilage, because once you perform surgery there is no going back.

SC21 also produces a wide range of stem-cell extract-based cosmetics and nutritional supplements, which are available at their medical centres and online under the brand SC21 Biotech.

The Thailand International Boat Show will feature Paul Collier and his team. Theyll be able to answer any of your questions about the cost, procedure, and treatment. On top of that, they will also assist you in educating yourself and managing your expectations so that you do not expect more than stem cell therapy can provide. If you want to get treatment, they will also provide you with a complete report on all treatments. SC21 is fully compliant with international regulations and guidelines.

http://www.stemcells21.com http://www.intellihealthplus.com

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SC21- 21st century cellular medicines specialists - The Thaiger