Stem Cell Clinic

[PDF] Stem Cell Therapy Market Size Strong Revenue and Generated Opportunities UNLV The Rebel Yell – UNLV The Rebel Yell

Stem cells are divided into two major classes; pluripotent and multipotent. Pluripotent stem cells are replicating cells, which are derived from the embryo or fetal tissues. The pluripotent stem cells facilitate the development of cells and tissues in three primary germ layers such as mesoderm, ectoderm, and endoderm.

Increasing expansion of facilities by market players for stem cell therapies is expected to propel growth of the stem cell therapy market over the forecast period. For instance, in January 2018, the University of Florida, U.S. launched the Center for Regenerative Medicine that is focused on development of stem cell therapies for the treatment of damaged tissue and organ. The Centre for Regenerative Medicines is divided into two segments such as focus groups and shared services. Focus groups such as research and development activities for stem cell therapies; and the shared services segment offers technical resources related to stem cell therapies.

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Furthermore, rising collaboration activities by key players are expected to drive growth of the global stem cell therapy market. For instance, in May 2018, Procella Therapeutics and Smartwise, a medtech company entered into a collaboration with AstraZeneca Pharmaceuticals. Under this collaboration, AstraZeneca utilized Procella Therapeutics stem cell technology for the development of stem cell therapies in cardiovascular diseases. Moreover, in April, 2019, CelluGen Biotech and FamiCord Group collaborated to develop new stem cell-based drugs and advanced medical therapies (ATMP)

Major Company Profiles Covered in This Report:Magellan, Medipost Co., Ltd, Osiris Therapeutics, Inc., Kolon TissueGene, Inc., JCR Pharmaceuticals Co., Ltd., Anterogen Co. Ltd., Pharmicell Co., Inc., and Stemedica Cell Technologies, Inc.

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Increasing research and development activities by the market players are one of the major factors that are expected to drive growth of the stem cell therapy market over the forecast period. For instance, in July 2018, the Emory Orthopaedics & Spine Center, in collaboration withSanford Health, Duke University, Andrews Institute, and Georgia Institute of Technology, received US$ 13 million grant from the Marcus Foundationfor a multicenter clinical trial studying stem cell options for treating osteoarthritis.The Phase 3 trial was initiated in March 2019, and is expected to complete by December 2021. Moreover, in December 2017, Mayo Clinic initiated the clinical phase I study on safety and feasibility of mesenchymal stem cell therapy in patients with intracerebral hemorrhage. This therapy is used for treating acute spontaneous hemorrhagic stroke. The study is expected to complete by December 2020.

Moreover, increasing product launches by key players is expected to boost demand for stem cell therapy over the forecast period. For instance, in August 2017, LifeCell, a healthcare service provider, launched an advanced umbilical cord-stem cell collection kit which offers enhanced protection to neonatal stem cells from environmental damage and temperature fluctuations.

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[PDF] Stem Cell Therapy Market Size Strong Revenue and Generated Opportunities UNLV The Rebel Yell - UNLV The Rebel Yell

Mike Tysons weird stem cell treatment has helped transform incredible body at 55 – Daily Star

Mike Tyson has claimed that he underwent stem-cell treatment several years ago, which transformed his body but left him feeling weird ever since".

Former heavyweight champion Tyson was one of the most physically intimidating boxers of all-time, boasting tremendous speed and devastating power throughout his career.

However, following his retirement from boxing in 2005, Tyson moved away from the sport entirely and began to gain weight.

This all changed several years ago, when Tyson made the decision to turn his life around and get back into fighting shape.

Alongside changing his diet and daily routine, Tyson recently stated that he underwent stem-cell therapy to aid his body transformation.

In recently resurfaced footage of an interview with LL Cool J on SiriusXM last year, via The Sun, Tyson told the rapper about undergoing the therapy, which aims to repair damaged cells within the body and treat or prevent illness.

"Yes. As they took the blood it was red and when it came back it was almost transfluid (sic), Tyson claimed.

"I could almost see through the blood, and then they injected it in me.

"And Ive been weird ever since, Ive got to get balanced now."

Who do you want to see Mike Tyson fight next? Let us know in the comments section below.

Since undergoing his incredible body transformation, Tyson has returned to boxing with incredible results.

He recently competed for the first time in over a decade-and-a-half in an exhibition bout against fellow legend Roy Jones Jr. While Jones looked out of shape, Tyson looked in peak condition.

While the bout was deemed a draw, Tyson won the bout in most viewers eyes and impressed throughout the contest.

After the pay-per-view success of his bout with Jones Jr, Iron Mike is expected to return to the ring again, either later this year or early next year.

An opponent has not yet been announced, however, Tyson has been training intensely with coach Rafael Cordeiro and looks ready for another fight very soon.

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Mike Tysons weird stem cell treatment has helped transform incredible body at 55 - Daily Star

Acute Monocytic Leukemia: Causes, Symptoms, and Treatment – Healthline

Leukemia is a group of cancers that affect your bone marrow and cause your body to produce abnormal blood cells. Acute myeloid leukemia (AML) is the most common type of leukemia in adults and accounts for about 4 out of 5 adult cases.

Acute monocytic leukemia (AML-M5) is a subtype of AML, in which at least 80 percent of the affected blood cells are a type of white blood cell called monocytes. Half of the people diagnosed with AML M5 are older than age 49.

AML-M5 causes similar symptoms in the early stages as other types of leukemia. These symptoms include:

In this article, we take a look at how acute monocytic leukemia differs from other leukemias, how its treated, and whats the outlook.

Leukemias develop in bone marrow stem cells that produce blood cells. Theyre classified based on the type of blood cells affected and how quickly the disease progresses. Heres how each main type is broken down:

AML is a type of leukemia that develops quickly (acute) and affects myeloid cells (myeloid).

AML-M5 is a subtype of AML that mainly affects the growth of monocytes. Monocytes have the potential to become two other types of white blood cells called macrophages and dendritic cells.

According to the National Cancer Institute, AML-M5 is diagnosed when more than 20 percent of white blood cells are abnormal or not fully developed, and more than 80 percent of the abnormal cells are monocytes or cells derived from monocytes.

Like many types of cancer, its not entirely clear why AML-M5 develops in some people and not others. However, it has been linked to certain genetic mutations.

In a 2019 study, genetic mutations were detected in 83.3 percent of people with AML-M5. The mutations FLT3-ITD and NRAS were most common.

Symptoms of AML-M5 are similar to those of many other forms of leukemia. Symptoms like fatigue or feelings of weakness are general and can have many potential causes.

Some other possible symptoms of AML-M5 include:

Many of the symptoms of leukemia are general and can have many different causes. A healthcare professional will likely want to order a blood test to look for signs of the disease, such as a high number of abnormal white blood cells or a low blood count.

If your blood test reveals signs of leukemia, youll likely be referred to a doctor called a hematologist, who specializes in blood conditions.

The next part of your diagnosis will likely involve a bone marrow biopsy, usually from your hip bone. During this procedure, an anesthetic will be applied to your skin. Then, the doctor will use a thin needle to remove bone marrow from the center of your hip bone.

The procedure usually takes about 20 to 30 minutes and shouldnt be painful. Your sample will then be taken to a lab for analysis.

Other supportive tests may be used to collect more information about the specific type of AML you have, how far it has progressed, and what the best treatment option may be.

AML-M5 can be difficult to treat due to a limited amount of research on the best way to manage this specific type of AML.

Treatment for most forms of AML involves multidrug chemotherapy and bone marrow transplants. The amount of chemotherapy you can receive depends on factors such as your age and overall health.

The goal of induction chemotherapy is to kill as many cancer cells as possible. It involves taking a high dose of chemotherapy drugs that target cancer cells. Unfortunately, it also targets healthy cells in your body that divide rapidly, such as blood stem cells, skin cells, and gastrointestinal cells.

The strength of the chemotherapy you can handle may depend on your age or overall health. Chemotherapy drugs are highly toxic to your bone marrow and can cause bleeding complications, kidney failure, and other potentially serious side effects, so your doctor will run tests often to check your health.

The chemotherapy drug cytarabine and either daunorubicin or idarubicin are often used in a 7+3 regimen. This mean you get cytarabine through an IV for 7 days, along with a small dose of one of the other medications on the first 3 days.

Here are a few other variations in the way this treatment might work:

Typically, youll stay in the hospital during the induction phase. If there are still signs of cancer in your body at the end of treatment, you may need another round of chemotherapy.

After going into remission, meaning the cancer is no longer detectable, most people undergo additional chemotherapy to target any remaining undetectable cancer cells and keep the cancer from coming back.

Young and healthy individuals often undergo several cycles of high-dose cytarabine combined with bone marrow transplants. Older adults or those with other coexisting health conditions may receive lower doses of cytarabine or other chemotherapy drugs.

High doses of chemotherapy damage the cells in your bone marrow that produce blood cells. A bone marrow transplant replaces damaged cells with healthy ones. Two types of transplants may be performed:

When a suitable donor is available, allogeneic transplants are the preferred procedure.

The outlook for people with AML-M5 has not been clearly established. However, it is known that it often progresses quickly when left untreated.

When your body makes too much of a protein called differentiation inhibitory factor, it may be linked to a less promising prognosis in some people.

About 40 percent of people with AML-M5 have a mutation in their Flt3 gene, which also may be associated with a less favorable outcome.

In a 2020 study, researchers found the 5-year overall survival rate was 46 percent in a group of 132 children with AML-M5. The overall survival rate was lowest in children under 3 years old.

Researchers are continuing to study AML-M5 in clinical trials to find the best way to treat this type of leukemia. Its likely the survival rate will continue to improve with time and new data.

Many types of leukemia that used to have high mortality rates are now very treatable, thanks to medical advancements. You can ask your doctor about clinical trials in your area, or you can search for them yourself from the U.S. National Library of Medicine.

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Acute Monocytic Leukemia: Causes, Symptoms, and Treatment - Healthline

UC Davis and the School of Medicine set new records in research funding – UC Davis Health

The University of California, Davis, set a new record for external research funding, receiving $968 million in awards in the fiscal year 2020-21, up $27 million from the previous record set last year. A major reason for this years growth was increased funding related to medicine and public health.

Professors Diana Farmer and Aijun Wang are collaborating to develop a stem cell treatment for spina bifida. (2019)

The School of Medicine received the largest increase in funding, up $92 million from the previous year, for a total of $368 million. Funding related to COVID-19 research totaled $42 million for the year. Studies in this area are providing critical insight into testing, vaccines, treatments and social impacts.

We are very proud of our researchers at the School of Medicine who rose to the challenge and expanded their groundbreaking work in the face of the pandemic, said Allison Brashear, dean of the UC Davis School of Medicine. All our research teams have shown great agility and collaboration across disciplines, quickly responding to emerging needs to prevent transmission and find treatments and vaccines to combat COVID-19, while also offering patients life-saving clinical trials in areas involving stem cell treatments, cancer and neuroscience, among many others.

Brashear noted that the School of Medicines clinical trials grew by 63% in the last year to $98 million.

The College of Agricultural and Environmental Sciences ($153 million), School of Veterinary Medicine ($83 million), College of Engineering ($80 million) and College of Biological Sciences ($58 million) rounded out the top five recipients.

This achievement reflects the unwavering commitment of our research community and their passion to address important societal needs during a year when operations were constrained due to the COVID-19 pandemic, Chancellor Gary S. May said. The societal impact of UC Davis research is far-reaching, spanning geographical boundaries and catering to diverse populations and needs.

The awards enable a broad range of research on topics including advancing human and animal health, protecting our planet and food supply and enabling a more resilient society.

The largest award, $51 million from the Department of Health and Human Services Centers for Disease Control and Prevention, went to Marc Schenker, distinguished professor of Public Health Sciences, to improve public health outcomes for all Californians by providing proper disease surveillance and prevention.

The federal government remains the largest provider of funding at $514 million, up $37 million from last year. The second leading source came from the state of California at $164 million, up $32 million. Funding from industry made up the third highest source, totaling $116 million, up $31 million.

UC Davis researchers received a total of 18 NSF CAREER Awards, a record for the university. These prestigious grants are offered to early-career faculty who have the potential to serve as academic role models in research and education and to lead advances in the mission of their department or organization.

Collaborative research bringing experts together from different fields of study continues to attract significant funding. These joint efforts often focus on addressing complex, large-scale challenges that require expertise from many perspectives.

We continue to see how multidisciplinary research provides a distinct advantage in tackling multifaceted issues, said Prasant Mohapatra, vice chancellor for Research at UC Davis. As one of the most academically comprehensive universities in the world, UC Davis offers a unique environment to solve these complex issues by bringing together experts from across our campuses.

Notable multidisciplinary awards include a $16 million grant from the National Institute of Mental Health for the UC Davis Conte Center to explore how infections in pregnancy lead to disorders in offspring. Principal investigators on this grant are Kimberly McAllister and Cameron Carter.

The Interdisciplinary Research and Strategic Initiatives division within the Office of Research offers support and resources to help teams advance their programs. Some of the notable interdisciplinary research projects include the work of Sheryl Catz, professor at the UC Davis Betty Irene Moore School of Nursing. Catz received $225,000 from the NIH National Cancer Institute for a project to improve the reach and effectiveness of smoking cessation services targeted to veterans living with HIV.

Diana Farmer, professor and chair in the Department of Surgery at UC Davis Health, also received $9 million from the California Institute for Regenerative Medicine (CIRM). Farmer is the principal investigator of the clinical trial, known formally as The CuRe Trial a cellular therapyfor in utero repair of myelomeningocele which uses stem cells before birth to treat the most serious form of spina bifida.

This story was originally written by Neelanjana Gautam and published here.

Note: Where funds are awarded up-front to cover several years, the money is counted in the first year the award was received. Incrementally funded awards are counted as authorized in each year. Reports are based on the principal investigators home school or college.

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UC Davis and the School of Medicine set new records in research funding - UC Davis Health

NCCN Issues Updated Guidelines Regarding Third COVID-19 Vaccine Booster for Those With Cancer – Cancer Network

The National Comprehensive Cancer Network (NCCN) has announced a significant update to the guidelines for COVID-19 vaccine administration, including a third dose, in patients with cancer, according to a press release issued by the organization.1

The recommendation indicated that several groups of individuals should be eligible for a third dose of the COVID-19 vaccine, including those with new or recurring solid tumors within 1 year of their initial vaccine dose regardless of therapy, as well as those with active hematologic malignancies. Patients who have received a stem cell transplant (SCT) or engineered cellular therapy such as CAR T-cell therapy within the past 2 years should also eligible, as well as those who are recipients of SCT on immunosuppressive therapy or with a history of graft-versus-host disease regardless of when the transplant took place.

COVID-19 can be very dangerous, especially for people living with cancer, which is why were so grateful for safe and effective vaccines that are saving lives, Robert W. Carlson, MD, chief executive officer of the NCCN, said in a press release. Our organization exists to improve the lives of people with cancer; we have a long track record for making recommendations that improve quality and length of life. We want our patients to live the longest and best lives possible, which means following the science on vaccination and mask-wearing.

The NCCN COVID-19 Vaccine Advisory Committee consists of multidisciplinary physicians across the NCCNs Member Institutions. In particular, the committee includes experts in infectious diseases, vaccine development and delivery, cancer management, and medical ethics. The recommendations, which are based on available evidence and expert consensus, have been utilized globally to aid in making management decisions over the course of the COVID-19 pandemic.

When it comes to peoples safety, we have to take every precaution, Steve Pergam, MD,

MPH, associate professor of the Vaccine and Infectious Disease Division at Fred Hutchinson

Cancer Research Center and infection prevention director at Seattle Cancer Care Alliance, as well as the co-leader of the NCCN COVID-19 Vaccination Advisory Committee, said in a press release. That means even after a third dose of vaccine, we still recommend immunocompromised peoplesuch as those undergoing cancer treatmentcontinue to be cautious, wear masks, and avoid large group gatherings, particularly around those who are unvaccinated. All of us should do our part to reduce the spread of COVID-19 and get vaccinated to protect those around us from preventable suffering.

Additional recommendations from the updated guidelines suggest that all eligible caregivers and close contacts of those with cancer should be immunized whenever possible.2 The use of all vaccines with FDA approval or emergency use authorizationincluding the Pfizer/BioNTech BNT162b2 mRNA vaccine (Comirnaty), the Moderna mRNA-1273 SARS-CoV-2 vaccine, and the Janssen Ad26.COV2.S Adenovirus vector vaccineis recommended in eligible patients by the committee.

Those who are receiving allogeneic or autologous SCT or CAR T-cell therapy will need to wait at least 3 months post-therapy before receiving the vaccine. Patients with hematologic malignancies, including those receiving cytotoxic chemotherapy such as cytarabine and anthracycline-based induction regimens for acute myeloid leukemia, need to delay inoculation until absolute neutrophil count recovery. Those who are experiencing marrow failure from their disease and/or are expected to have limited or no recovery from their therapy as well as those who are receiving long-term maintenance are able to receive the vaccine once it is available.

In solid tumors, the vaccine may be received once available for those who are undergoing treatment with cytotoxic chemotherapy, targeted therapy, checkpoint inhibitors, and other immunotherapy or radiation therapy. Those who are undergoing major surgery need to wait a few days following their surgical procedure before getting the vaccines.

The Center for Disease Control (CDC) currently recommends a third dose of the mRNA COVID-19 vaccines for individuals who are moderately to severely immunocompromised. This includes:

The CDC recommends that a third dose of the mRNA COVID-19 vaccine should be given at a minimum of 4 weeks following the second dose of either the Moderna or Pfizer vaccines. Notably, although preliminary data indicate that a third dose could augment antibody titers in an immunocompromised population of patients, those who have been diagnosed with cancer continue to be at a higher risk for infection with COVID-19 and COVID-19related complications. Even with the additional dose, infection is still possible meaning that precautions such as avoiding crowds and wearing a mask are recommended.

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NCCN Issues Updated Guidelines Regarding Third COVID-19 Vaccine Booster for Those With Cancer - Cancer Network

DHEC Supports Awareness and Education during National Sickle Cell Awareness Month – SCDHEC

FOR IMMEDIATE RELEASE: Aug. 30, 2021

COLUMBIA, S.C. Sickle cell disease is a serious genetic disorder that impacts many families around the country and around the world. The South Carolina Department of Health and Environmental Control (DHEC) supports the annual recognition of September as National Sickle Cell Awareness Month to help focus attention on the need for further research and treatment of sickle cell disease.

As the most common inherited blood disorder in the United States, sickle cell disease (SCD) currently affects approximately 100,000 Americans, including more than 4,000 South Carolinians who have the disease. Complications from SCD include pain attacks that can cause the individual to need hospitalization. Other potentially life-threatening complications include infections, stroke, and organ damage.

Because symptoms and complications of SCD can vary, treatment options are different for each person depending on their symptoms. The only known cure for SCD is bone marrow or stem cell transplant.

Sickle cell disease can be a debilitating and life-threatening disease for those who have it, and it can also affect the lives of their family and friends, said Dr. Brannon Traxler, DHEC Public Health Director. While September is National Sickle Cell Awareness Month, increasing public knowledge about sickle cell should be a year-long initiative.

The theme of this years monthly recognition is Sickle Cell Matters, which underscores the need to raise awareness about the daily struggles of those living with SCD as well as the need to address the stereotypes and stigmas associated with people who have the disorder.

Babies are born with SCD; it isnt a disease that someone can develop later in life. In people who are born with SCD, both copies of a hemoglobin gene are abnormal. A person born with one abnormal copy of the gene and one normal copy has "sickle cell trait." People with sickle cell trait usually don't have symptoms although in rare cases they can experience complications of SCD like pain crises. When two people with sickle cell trait have a child, there is a 25-percent chance the child will have SCD. Even if only one parent has a sickle cell trait, their child could still have an increased risk of inheriting a type of sickle cell disease.

Blood tests can confirm whether a person has sickle cell trait or SCD, and the disorders are commonly detected during newborn health screenings.

SCD disproportionally affects those with African ancestry or who identify as Black. The disease also can be found in anyone with genetic makeup from a part of the world where malaria is more widely spread, such as India, South America and Central America.

South Carolina has a Sickle Cell Disease State Plan developed by a group of dedicated partners who work to help mitigate this life-threatening disorder, said Dr. Traxler. We can all help increase awareness about sickle cell disease by sharing education and information within our communities, especially in minority or underserved communities that may struggle with access to routine health care.

In 2017, South Carolina established the South Carolina Sickle Cell Disease Advocacy Team, which remains focused on one common goal to improve the treatment and care received by individuals and their families who have sickle cell disease.

DHEC provides a printable sickle cell disease flyer available for anyone here. Organizations can order printed copies of the flyer for distribution by placing an order here. Learn more about the disease at cdc.gov/sicklecell.

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About the South Carolina Sickle Disease Advocacy Team Members of the South Carolina Sickle Cell Disease Advocacy Team (SCSCDAT), who came together to develop the South Carolina Sickle Cell Disease State Plan, include physicians, hematologists, government agencies non-profit organizations, healthcare management organizations and individuals living with SCD and their family members.

Media Contacts:

COBRA Sickle Cell Program http://www.cobraagency70.com/home.html sicklecell@cobraagency70.com 843-225-4870

Louvenia D. Barksdale Sickle Cell Anemia Foundation http://www.ldbarksdalesc.org/ ldbarksdalesc@gmail.com 864-582-9420

James R Clark Memorial Sickle Cell Foundation http://www.jamesrclarksicklecell.org office@jamesrclarksicklecell.org 803-799-6471

Orangeburg Area Sickle Cell Anemia Foundation orangeburgsickle@gmail.com 803-534-1716

The B Strong Group thebstronggroup.org thebstronggroup@gmail.com 803-875-1266

DRE 365 (Dream Reach Empower) dre365sc@gmail.com 803-759-0700

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DHEC Supports Awareness and Education during National Sickle Cell Awareness Month - SCDHEC