Telix and Merck KGaA, Darmstadt, Germany, to Commence Pan-Cancer Clinical Combination Studies

MELBOURNE, Australia, Aug. 17, 2021 (GLOBE NEWSWIRE) -- Telix Pharmaceuticals Limited (ASX: TLX, ‘Telix’, the ‘Company’) today announces that it has entered into a pan-cancer clinical collaboration with Merck KGaA, Darmstadt, Germany, to conduct combination studies with one of Merck KGaA, Darmstadt, Germany’s investigational proprietary DNA Damage Response Inhibitor (DDRi) molecules in combination with each of Telix’s TLX591 (177Lu-rosopatamab) and TLX250 (177Lu-girentuximab) molecularly targeted radiation (MTR) therapeutic programs. This clinical collaboration builds on the success of a strategic research collaboration agreement between Telix and Merck KGaA, Darmstadt, Germany announced in August 2019.1

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Telix and Merck KGaA, Darmstadt, Germany, to Commence Pan-Cancer Clinical Combination Studies

Telix and Merck to Commence Pan-Cancer Clinical Combination Studies

MELBOURNE, Australia, Aug. 18, 2021 (GLOBE NEWSWIRE) -- Telix Pharmaceuticals Limited (ASX: TLX, ‘Telix’, the ‘Company’) today announces that it has entered into a pan-cancer clinical collaboration with Merck KGaA, Darmstadt, Germany (‘Merck’), to conduct combination studies with one of Merck’s investigational proprietary DNA Damage Response Inhibitor (DDRi) molecules in combination with each of Telix’s TLX591 (177Lu-rosopatamab) and TLX250 (177Lu-girentuximab) molecularly targeted radiation (MTR) therapeutic programs. This clinical collaboration builds on the success of a strategic research collaboration agreement between Telix and Merck announced in August 2019.1

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Telix and Merck to Commence Pan-Cancer Clinical Combination Studies

Two New Studies to Explore Telix Assets in Breast Cancer Theranostics

MELBOURNE, Australia, Aug. 18, 2021 (GLOBE NEWSWIRE) -- Telix Pharmaceuticals Limited (ASX: TLX, ‘Telix’, the ‘Company’) today announces the initiation of two new investigator-led studies to evaluate the potential utility of the Company’s late-stage imaging portfolio in women’s health, initially in two sub-types of breast cancer with a significant unmet medical need. Both TLX591-CDx and TLX250-CDx have potential utility in breast cancer imaging, particularly for specific phenotypes that are not consistently well imaged using existing techniques.

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Two New Studies to Explore Telix Assets in Breast Cancer Theranostics

Selma Blair Shares That Shes Now in Remission 3 Years After MS Diagnosis – Self

Three years after actor Selma Blair received her multiple sclerosis (MS) diagnosis, her treatment is working well and her prognosis is positive.

"My prognosis is great. I'm in remission. Stem cell put me in remission," Blair said at a TCA panel in support of the upcoming Introducing Selma Blair documentary, per People. "It took about a year after stem cell for the inflammation and lesions to really go down."

Multiple sclerosis is thought to be an autoimmune condition that occurs when the body's immune system begins attacking the protective myelin sheaths that coat and protect nerve fibers. That can cause communication issues along the nerves and, over time, lead to permanent nerve damage.

People who have MS can have a range of symptoms such as fatigue, dizziness, tingling, balance issues, muscle weakness, and changes in vision (like blurred vision or double vision). The symptoms typically come and go, and someone may experience a flare of their symptoms (that can last days, weeks, or months) or they might be in a period of remission when their symptoms wane (but don't necessarily disappear completely).

Although there is no cure for MS, there are a variety of medications and treatment options that can help manage the symptoms. Experts are still researching and developing stem cell therapy for MS, the type of treatment Blair mentioned. To use stem cells to manage more aggressive forms of MS, doctors will typically perform an autologous stem cell transplant, the Mayo Clinic says, meaning they'll take a patient's own stem cells and use them to replenish their bone marrow. This type of stem cell transplant is most commonly used in the treatment of conditions such as myeloma, Hodgin's lymphoma, and non-Hodgkin's lymphoma, the Mayo Clinic says.

Blair was first diagnosed with MS in 2018 after dealing with symptoms like falling, dropping things, chronic pain, and a foggy memory, she revealed in an Instagram post. At first, Blair said she attributed her symptoms to a pinched nerve, but received her diagnosis after undergoing an MRI.

She told the panel that, for the past few months, she's been feeling noticeably better. But she was reluctant to talk about her improvements publicly because she felt like she still needed to be more healed and more fixed, People reports. "I've accrued a lifetime of some baggage in the brain that still needs a little sorting out or accepting. That took me a minute to get to that acceptance. It doesn't look like this for everyone."

In grappling with her diagnosis, Blair has found that being open with how she's feeling and what her life looks like now have been helpfulfor herself and others. "To hear even just me showing up with a cane or sharing something that might be embarrassing, it was a key for a lot of people in finding comfort in themselves and that means everything to me," she said.

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Selma Blair Shares That Shes Now in Remission 3 Years After MS Diagnosis - Self

Third dose of COVID-19 vaccine to be offered to certain residents – Martins Ferry Times Leader

Coronavirus

Aug 18, 2021

WOODSFIELD Local health departments will offer a third dose of the COVID-19 vaccine to immunocompromised residents in an effort to help further protect those individuals from the virus.

The Centers for Disease Control and Prevention and the Ohio Department of Health announced a recommendation for a third dose of Moderna or Pfizer for immunocompromised individuals who have been fully vaccinated more than 28 days ago. Those who qualify include:

Individuals undergoing active treatment for cancer (solid tumor and hematologic malignancies);

Individuals who have received a solid-organ transplant and are taking immunosuppressive therapy;

Individuals who have received a CAR-T-cell or hematopoietic stem cell transplant (within two years of transplant or taking immunosuppression therapy);

Individuals with moderate or severe primary immunodeficiency (e.g., DiGeorge syndrome, Wiskott-Aldrich syndrome);

Individuals with advanced or untreated HIV infection;

Individuals undergoing active treatment with high-dose corticosteroids (i.e., =20mg prednisone or equivalent per day), alkylating agents, antimetabolites, transplant-related immunosuppressive drugs, cancer chemotherapeutic agents classified as severely immunosuppressive, tumor-necrosis (TNF) blockers, and other biologic agents that are immunosuppressive or immunomodulatory.

The Monroe County Health Department will hold a third dose clinic Aug. 26 at the health department in Woodsfield. Amanda Sefert, public information officer of the county health department, said the clinic will be by appointment only. For more information on whether a person may qualify or to make an appointment for the third dose, call 740-472-4299 and leave your name, number and birthdate.

She said a staff member will return the call to answer questions.

Sefert said the third dose is needed to help further build the immune system of immunocompromised people. According to the CDC, severely compromised immune systems do not always build the same level of immunity compared to people who are not immunocompromised. Receiving the third dose will help prevent those individuals from contracting the virus or lessen the symptoms if they do, she said.

The health department is also offering youth clinics for ages 12-17. With school set to begin soon, Sefert said they wanted to help ensure students have access to the vaccine. She said there has been a fairly positive response for the clinics and she is hoping for a good turnout. The next youth clinic is set for 9:30-11:30 a.m. and 1:30-3:30 p.m. Thursday at the health department, with another set for 11 a.m. to 1 p.m. Aug. 27 at the EMS Pavilion during the county fair.

With the information from the delta variant coming out, I think more people are concerned, she added.

The Harrison County Health Department will offer third doses to residents who meet the qualifications and have received a recommendation from a doctor. Garen Rhome, administrator of the county health department, said there is only a small population who meet the qualifications so a clinic will not be necessary in his county.

What we want people to do is to get documentation from their providers. We just want to make sure they are part of that very select group that is currently recommended for the third dose of the series, so we want to know that their doctor recommends that they get it and then we can help them from there, he said.

To schedule an appointment for a third dose, call the health department at 740-942-2616.

Belmont County Deputy Health Commissioner Robert Sproul said his department is planning a third dose specific clinic. He said they are still working on a day and location. The department is currently only administering first and second doses out of the health department office. The department frequently posts upcoming clinics on its Facebook page.

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Third dose of COVID-19 vaccine to be offered to certain residents - Martins Ferry Times Leader

Friends, family continue Jocelyn’s drive to increase stem cell donors – Chatham This Week

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The importance of stem cell donation became a key part of Jocelyn McGlynns fight against leukemia.

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An aspiring doctor, the Chatham woman may have lost the battle, but she has inspired friends and family to continue her mission to increase the number of potential stem cell donors across Canada.

A total of 135 units of blood were collected during a blood donation clinic held in Jocelyns memory at the Chatham YMCA on Aug. 10, just days before those who loved the Western University medical science student will mark the first year of her death at age 23.

People at the clinic were also encouraged to join Canadas national stem cell registry.

Family friend Megan Canniff, who helped organize the event, said the clinic was a rewarding experience.

Jocelyn was just such an inspiration. I feel very blessed to be able to continue doing what she started, Canniff said. Its a good feeling and it makes you feel a little closer to her as well, being part of something she was so passionate about.

Canniff said a good number of people donated blood for the first time because they were inspired by Jocelyns passion.

Its really great to see. Hopefully, the impact is going to be continued in the future, she said.

Not long after Jocelyn was diagnosed with leukemia in the fall of 2018, she and her family dedicated themselves to promoting stem cell donor registration.

I think its so important because it was so important to our Jocey, said her mother, Jacquelyn McGlynn.

Jocelyns father, Peter McGlynn, said its heartening to know this kind of effort is helping someone else because so many people helped us.

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He said Jocelyn received numerous blood products because of people that were thinking, perhaps, of somebody else that had issues.

Having seen what his daughter started, he said it was critical to continue advocating for the things that she thought were important.

It brings sad memories, but this is what she would have wanted us to do, he said.

However, McGlynn said the clinic also brought happiness to the family knowing Jocelyns friends have embraced her cause.

Its lovely to see them and to know that they still think about her and love her, he said. Were very proud of these young folks.

A single donation of blood is equal to one unit of blood, and a leukemia patient can require up to eight units of blood per week.

As McGlynn wrote: Everybody join the team, theres a cure in your bloodstream.

Maureen Macfarlane, event co-ordinator with Canadian Blood Services, said there is an increased need for blood donations as hospital procedures, which were previously on hold during the COVID-19 pandemic, are being scheduled.

Another blood donor clinic is being held in Chatham on Aug. 31 from 1 p.m. to 7 p.m. at the Retro Suites Hotel.

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Calidi Biotherapeutics Announces Exclusive License Agreement with City of Hope and the University of Chicago for Novel Oncolytic Virotherapy…

Details Category: DNA RNA and Cells Published on Monday, 16 August 2021 17:11 Hits: 487

LA JOLLA, CA, USA I August 16, 2021 I Calidi Biotherapeutics, Inc., a clinical-stage biotechnology company with novel allogeneic stem cell platforms for delivery of oncolytic viruses, together with the University of Chicago and City of Hope, a world renowned NCI-Designated Comprehensive Cancer Center, based in Duarte, California, have entered into an exclusive worldwide licensing agreement for patents covering cutting edge therapies using an oncolytic adenovirus in combination with a clinical grade allogeneic neural stem cell line.

City of Hope (COH) scientists, led by Dr. Karen Aboody in collaboration with Dr. Maciej Lesniak's team at University of Chicago, and later Northwestern University, have used COHs exclusive GMP grade immortalized, clonal human neural stem cell line, to selectively deliver an oncolytic adenovirus to tumor sites. Dr. Aboody and Dr. Lesniak, together with Dr. Rachael Mooney at COH, have spent 13 years in a passionate effort to translate promising pre-clinical results into the clinic, attaining FDA approval for commencing a first-in-human Phase-1 trial in recurrent glioma patients.

We are very excited about the partnership and collaboration with Calidi Biotherapeutics. Their deep understanding and expertise using allogeneic stem cells as a delivery platform to protect, deliver, amplify, and potentiate oncolytic virotherapy, can potentially result in a significantly more effective treatment for cancer patients with invasive tumors, commented Dr. Karen Aboody, Professor, Department of Developmental and Stem Cell Biology, City of Hope National Medical Center & Beckman Research Institute.

The first wave of Oncolytic Viruses were novel, but lacked the ability to efficiently deliver the virus to tumor sites, due to the human complement immune system inactivating the viruses, usually within one hour of patient injection, thus resulting in a lack of efficacy, stated Allan Camaisa, Co-Founder, Chairman and CEO of Calidi Biotherapeutics. We believe this collaboration with City of Hope will allow us to implement Calidis proprietary techniques together with City of Hopes novel approach to glioblastoma and other malignant tumors, using neural stem cells combined with an oncolytic adenovirus. This FDA approved Investigational New Drug (IND), planned for patient trials in the first quarter of 2022, increases Calidis drug pipeline and gives our company a tumor-tropic stem cell line to use for oncolytic virus delivery in cancer patients.

This exclusive license agreement, which was executed by the University of Chicagos Polsky Center for Entrepeneurship and Innovation, transferred the COH/University of Chicago IND to Calidi for the commercial development of a licensed product. The agreement grants to Calidi commercial exclusivity in using neural stem cells with the adenovirus known as CRAd-pk-S-7 for oncolytic virotherapy.

Calidis scientific and medical teams are very excited to contribute in the development of this promising technology that has significant potential to help many patients with advanced tumors, said Boris Minev, MD, President, Medical and Scientific Affairs at Calidi Biotherapeutics. We are delighted to collaborate with the outstanding researchers and clinicians who developed this novel oncolytic virotherapy approach.

About Calidi Biotherapeutics

Calidi Biotherapeutics is a clinical-stage immuno-oncology company with proprietary technology that is revolutionizing the effective delivery of oncolytic viruses protected by stem cells for targeted therapy against difficult-to-treat cancers. Calidi Biotherapeutics is advancing a potent allogeneic stem cell and oncolytic virus combination for use in multiple oncology indications. Calidis off-the-shelf, universal cell-based delivery platform is designed to protect, amplify, and potentiate oncolytic viruses currently in development leading to enhanced efficacy and improved patient safety. Calidi Biotherapeutics is headquartered in San Diego, California. For more information, please visit http://www.calidibio.com.

About University of Chicago

The University of Chicago is a leading academic and research institution that has driven new ways of thinking since its founding in 1890. As an intellectual destination, the University draws scholars and students from around the world to its campuses and centers around the globe. The University provides a distinctive educational experience and research environment, empowering individuals to challenge conventional thinking and pursue field-defining research that produces new understanding and breakthroughs with global impact.

The Polsky Center for Entrepreneurship and Innovation applies world-class business expertise from the University of Chicago Booth School of Business to bring new ideas and breakthrough innovations to market. Home of the Universitys technology transfer office, the Polsky Centers dedicated team of professionals with deep technical expertise enabling technology commercialization perform market analysis, manage intellectual property, identify partners, and negotiate partnerships and licenses for discoveries and inventions developed by faculty, researchers, and staff. Learn more at polsky.uchicago.edu and follow us on Twitter @polskycenter.

About City of Hope

City of Hope is an independent biomedical research and treatment center for cancer, diabetes and other life-threatening diseases. Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy. City of Hopes translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies, and numerous breakthrough cancer drugs are based on technology developed at the institution. Translational Genomic research (TGen) became a part of City of Hope in 2016. AccessHope, a wholly owned subsidiary, was launched in 2019, dedicated to serving employers and their health care partners by providing access to City of Hopes exceptional cancer expertise. A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nations Best Hospitals by U.S. News & World Report. Its main campus is located in Pasadena, California, near Los Angeles, with additional locations throughout Southern California and in Arizona. For more information about City of Hope, follow us on Facebook, Twitter, YouTube, or Instagram.

SOURCE: Calidi Biotherapeutics

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Calidi Biotherapeutics Announces Exclusive License Agreement with City of Hope and the University of Chicago for Novel Oncolytic Virotherapy...

LSU Health Shreveport Vaccine Clinic at 2726 Linwood Avenue to Begin Administering Third Doses of Vaccine Tomorrow for Those Who Meet CDC Requirements…

Shreveport LSU Health Shreveport will begin administering the third dose (booster) vaccines starting tomorrow from 10am to 6pm, Monday through Friday at 2627 Linwood Avenue/former Chevyland. Third doses will be administered based on CDC guidelines and recommendations by the Louisiana Department of Health.

In an effort to minimize wait times, it is suggested that those seeking the third dose of the vaccine do so based on the following schedule.

Last name begins with letters:

A F should get third vaccine on Tuesday, August 17

G-L should get third vaccine on Wednesday, August 18

M-S should get third vaccine on Thursday, August 19

T-Z should get third vaccine on Friday, August 20

If you are unable to come on suggested date, please feel free to come when you are available. Appointments are not required for third dose of vaccine.

Third doses will be available for people whose immune systems are compromised moderately to severely and are fully vaccinated with an mRNA COVID-19 vaccine. This action is being taken as those who are moderately to severely immunocompromised are especially vulnerable to COVID-19 because they are at a higher risk of serious, prolonged illness. As of Friday, August 13, 2021, CDC now recommends that people with moderately to severely compromised immune systems receive an additional dose of mRNA COVID-19 vaccine at least 28 days after their second dose of Pfizer-BioNTech COVID-19 vaccine orModerna COVID-19 vaccine. CDC doesnotrecommend additional doses or booster shots for any other population at this time.

Patients will self-attest to their condition by completing and signing this formhttps://ldh.la.gov/assets/oph/Center-CP/HANs/HANS21-58Attachment-3rdDoseAttestationForm.pdf.

Who Needs an Additional COVID-19 Vaccine?

Currently, CDC is recommending that moderately to severely immunocompromised people receive an additional dose. This includes people who have:

Been receiving active cancer treatment for tumors or cancers of the blood

Received an organ transplant and are taking medicine to suppress the immune system

Received a stem cell transplant within the last 2 years or are taking medicine to suppress the immune system

Moderate or severe primary immunodeficiency (such as DiGeorge syndrome, Wiskott-Aldrich syndrome)

Advanced or untreated HIV infection

Active treatment with high-dose corticosteroids or other drugs that may suppress your immune response

Other conditions which cause moderate or severe immunosuppression similar to the above conditions

People should talk to their healthcare provider about their medical condition, and whether getting an additional dose is appropriate for them.

Prescription or notation from a physician or other prescriber is not necessary at this time.Patients with one of the above conditions who wish to receive an additional dose of Pfizer or Moderna vaccine may self-attest to their condition by completing and signing this form.

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LSU Health Shreveport Vaccine Clinic at 2726 Linwood Avenue to Begin Administering Third Doses of Vaccine Tomorrow for Those Who Meet CDC Requirements...

Eagle County begins offering third vaccine doses to the immunocompromised – Vail Daily News

Eagle County hit the ground running in its effort to provide third doses of COVID-19 vaccine to immunocompromised residents who wish to receive them, offering the first doses at clinics mere days after a federal advisory committee recommended the booster shots.

On Friday, an advisory committee to the Centers for Disease Control and Prevention approved an additional dose of the two mRNA vaccines Pfizer and Moderna for moderately to severely immunocompromised people.

By Monday, the MIRA Bus, an RV that travels the county offering public health services, was offering third doses at a mobile clinic in Avon. Colorado Mountain Medical will offer the third shots to qualifying individuals at its Eagle campus every Thursday from 8 a.m. to 4 p.m.

We know the third dose booster with this population provides more protection for them and is recommended on a disease severity piece that theyll have more protection, said Chris Lindley, Vail Healths chief population health officer. So, we dont want to wait, even though the guidance is not as clear as we would like it.

The CDC outlined six categories of people that will qualify as immunocompromised in this first phase, an eligibility group much smaller than the definition of immunocompromised used in the initial vaccine rollout earlier this year, Eagle County Public Health Director Heath Harmon said.

In the spring, the immunocompromised priority group contained about 20,000 Eagle County residents, but this new group is likely much smaller, Harmon said.

During the initial vaccine rollout, everybody was vulnerable to the illness at that time, he said. So now, when were looking at third doses, we do have access to a lot of data, especially relative to individuals that may have already received two doses of an mRNA vaccine. So, its really helpful to be more specific in terms of who can benefit most from that third dose.

Among the eligible are those receiving active cancer treatment for tumors or cancers of the blood as well as people who have received an organ transplant and are taking medication that suppresses the immune system, according to the CDC.

Anyone who received a stem cell transplant within the past two years, is currently taking immunosuppressant medication or has a moderate or severe primary immunodeficiency is also eligible, according to the guidance.

The last two groups included are those with advanced or untreated HIV or who are actively receiving treatment with high-dose corticosteroids or other drugs that may suppress your immune response.

The relatively vague language of some of these groups leaves a little bit to be desired, Lindley said, and the guidance does not say anything about requiring proof of eligibility from a medical provider, so Vail Health and Colorado Mountain Medical will not do so at this time.

The guidance also does not provide a booster option for immunocompromised people who received the single-shot Johnson and Johnson vaccine. Currently, there is no additional shot available for the Johnson and Johnson vaccine, and it cannot be mixed with Pfizer or Moderna.

To those in that situation, we hear you, Harmon said. We understand that you have some questions, and we just ask for patience. We would expect for guidance to be available from our federal partners in the not-too-distant future.

The most important thing is that Eagle County now has one more prevention tool in its belt to help protect its most vulnerable residents, Harmon said.

Colorado Mountain Medicals Thursday clinics will continue to offer first and second doses of the COVID-19 vaccine to anyone who has yet to receive it, in addition to the third doses, said Shannatay Bergeron, director of specialty care services for Colorado Mountain Medical.

The clinics will be walk-in only and demand for third shots may be high, especially at first, so Bergeron cautioned residents to prepare for a wait. The MIRA Bus will be at the Eagle Colorado Mountain Medical location Thursday providing additional vaccination capacity, she said.

Eligible residents should bring a form of identification proving their age along with their vaccination card. More information on the Thursday clinics, as well as other COVID-19 and vaccination updates, can be found at vailhealth.org/COVID-19/vaccines.

Eagle County Public Health is also offering third doses at its locations in Eagle and Avon, Harmon said Tuesday.

Though the third shots were made available beginning Monday, Harmon said he did not think anyone had received one yet. More information on the countys clinics can be found at EagleCountyCOVID.org.

Vail Healths aggressive approach to offering the third shots as soon as possible is on par with how Eagle County has handled the entire pandemic thus far, Lindley said with pride.

It has always been our objective in dealing with COVID to be as aggressive and quick in the response as we possibly can, he said. We did it with testing by standing up the first drive-thru test center in the state. We were the first hospital to receive the mass vaccination distribution from the state of Colorado.

Once we heard whispers that this was likely coming, aligning with that aggressive approach, we started planning, staffing, we ordered more vaccine and supplies so we had it all on hand by last week so we would be ready to go, Bergeron said.

Part of the reason why Colorado Mountain Medical was able to mobilize so quickly was due to the significant surplus of vaccine doses in Eagle County, but also across the United States, Lindley said.

The United States has millions and millions, hundreds of millions, of doses of vaccine that are available, he said. Theres no shortage of vaccine in the United States of America.

The third shot has not been recommended for the broader population quite yet but, based upon murmurings about an announcement from the CDC and President Joe Bidens administration, guidance for the general public is likely to come soon, Lindley said.

Harmon said he cannot be sure whether a subsequent priority group will be announced or if eligibility for the third doses will be opened to all.

I would imagine that theyll continue to look at data and still look first and foremost at whos going to benefit most from receiving third doses, he said. We may see an additional tier 2 group for immunocompromised individuals in the future.

Lindley urged residents to continue following local, state and federal public health guidance and to get a third shot as they are eligible to maintain their immunization against COVID-19 as community spread of the Delta variant continues to rise.

Just like the annual influenza vaccines, I think we should all prepare to get annual or even more frequent COVID-19 vaccines, Lindley said. COVID is here to stay. I do not believe there will be a time in our lives that we will be alive that COVID is not here.

Theres six very common circulating COVID viruses that have been around for hundreds of years. Its our common cold. This is just another dimension of it, he continued. Its going to continue to mutate, so, we need to learn to deal with it, to protect ourselves and to do that immunization is our best tool. So, stay immunized, stay protected.

Email Kelli Duncan at kduncan@vaildaily.com

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Eagle County begins offering third vaccine doses to the immunocompromised - Vail Daily News