Stem Cell Clinic

Canada’s blood supply has a diversity problem and people are dying because of it – CBC.ca

By adminFebruary 2, 2021Stem Cell Doctors

Lauren Sano with her father Mark, seen here last year when he was in hospital being treated for a rare form of leukemia. Mark Sano died in October of 2020. He was 52.

Lauren Sanostill wonders,if things were different, whether her father's life couldhave been saved.

"You always wonder if there was someone in the registry who was a bettermatch would have resulted in better outcomes and less transplant complications."

Mark Sanowas a 52-year-old Toronto father of three. He worked in the financial industry as a marketing manager and in his spare time was an avid sportsman who loved tennis, hockey and especially skiing.

In November of 2019 he was diagnosed with a rare form of leukemia. The only thing that couldsave his life, doctors told his family,was a stem cell transplant;a critical treatment for blood cancers and dozens of other diseases.

According to Canadian Blood Services (CBS), stem cells are the body's basic building blocks the raw material from which all cells are made. In blood, stem cells can become red, white blood cells or even blood platelets.

"Without stem cells, the body cannot make the blood cells needed for the immune system to function," CBS says, which runs the national blood bank.

It says a patient must find a match with a donor, and that is usually a person who shares the same ethnic background.

CBS says right now, donors to Canada's blood stem cell registry are more than two-thirds Caucasian, with the other third fracturedin uneven splintersacross race and ethnicity.

It means an Asian patient like Sano, according to the Canadian Blood Services stem cell registry, would have anywhere from seven to less than one per cent chanceof finding a match, depending on hisparticular genetic background.

So when the Sano family sought a match, they found a lack of minority donors who were aclose enough. Sano's daughter Lauren was the closest they could find and even then, she was far from ideal.

"I ended up being a half-match for him and was his donor.It was the most fulfilling and grounding experience."

As fulfilling as it was, it wasn't enough.Sano died at Princess Margaret Hospital in October 2020, 18 months after he was first diagnosed.

Lauren still wonders, whether her dad's life could have been saved, had they found the right donor from a more racially diverse pool of donors.

"I feel very lucky I was able to give him the gift of life.I was at least grateful that I was able to do this for my dad."

The dearth of diversity in Canada's stem cell registry is a problem Canadian Blood Services is familiar with, according toHeidi Elmoazzen, the agency's director of stem cells. Shehas been actively working on increasing the pool of minority donors to give minority patientsa better shot at getting better.

"We find that people tend to find matches within the same ethnic or racial background as them, which is why we're trying to build a registry that reflects the unique diversity we have here in Canada."

Some groups are more diverse than others when it comes to the make up of their stem cells, according to Elmoazzen. For example, she saysBlack people tend to be the most diverse.

A Black person whose ancestors are from the Caribbean might not have the same markers as someone from say, eastern Africa, which makes finding a match challenging.

Adding to the complication is that to harvest stem cells, you literally need young blood.Only young people, between the ages of 17 and 35 can apply.

The ongoing COVID-19 pandemic has also disrupted recruitment efforts, Elmoazzen says.Canadian Blood Services finds 60 to 70 per cent of its potential stem cell donors during its community clinics and with everyone staying home, the number of people visiting is down.

"It's had a heavy impact on our ability to recruit donors this year," she adds.

Still, virtual drives are underway. People interested in donating can still sign up through the Canadian Blood Services website.

There are also volunteers like Lauren Sano, who along with a number of Western University students will be pushing for donations in a virtual blood stem cell drive this month in honour of Black History Month and in April.

The hope is that by reaching out to diverse communities, Sanosays her goal is to help people make donating blood a habit. She says she hopes that willnot only will boost the blood supply, but the supply of blood products, such as stem cells and platelets as well.

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Canada's blood supply has a diversity problem and people are dying because of it - CBC.ca

Dean Tracy Johnson seeks to diversify the pipeline of future scientists and doctors – UCLA Newsroom

By adminFebruary 2, 2021Stem Cell Doctors

When Tracy Johnson was an undergraduate working in a lab at UC San Diego, she found herself suddenly jolted. Conducting research on gene function using fruit flies, she realized she was involved in something deeper and more fulfilling than a traditional classroom experience.

The idea that I was learning things that nobody else knew, that I could make some contribution, says the dean of the division of life sciences in the UCLA College, that was a game-changer.

Johnson, who holds the Keith and Cecilia Terasaki Presidential Endowed Chair in Life Sciences, joined the faculty of UCLAs Department of Molecular, Cell andDevelopmental Biology in 2014. Soon after, she was awarded a $1 million Howard Hughes Medical Institute grant to improve undergraduate science education, which was, in part, used to create the UCLA-HHMI Pathways to Success program.

Pathways gives students from diverse backgrounds an authentic research experience, early on, and in a prolonged way. For years, Johnson said, students of color and those who were the first in their family to attend college pursued science, technology, engineering and math degrees at equal rates as other students but left STEM majors at a higher rate.

It was clear that these statistics had less to do with preparation, she said, and more to do with students not seeing themselves as part of a scientific community. Pathways was designed to rethink that.

The goal was to help students understand they belonged and had important contributions to make.

The Pathways program has honestly opened up the world of research to me. I come from a normal public school in a mainly minority area, so I never knew what research truly entailed, said Venus Hagan, a second-year UCLA student majoring in molecular, cell and developmental biology and minoring in biomedical research.

Hagan noted how getting to do research as an undergraduate helped her discover her passion for it. Without the program, she said, I may have never considered minoring in biomedical research and possibly applying to MD/Ph.D. programs in the future.

In building the program, Johnson looked around the country to find what worked best, and bring it to UCLA. She was interested not just in lab work, but in mentoring as well.

Pathways students participate in a lab course dedicated to Johnsons field, gene expression. The DNA in every cell of a given plant or animal is identical. Expression is the process by which genes, or specific segments of DNA, get turned on. This process allows cells to perform specific functions. For example, this process can tell a cell to become part of a muscle or part of the brain, and so on.

Its a lot for first-year students to dive into, Johnson acknowledged. Theyre freshmen, on campus for barely 10 weeks when they start. Some students have never taken AP biology. It is ambitious, but they rise to the occasion.

Second-year student Nyari Muchaka said enrolling in Pathways was one of the best decisions she has ever made.

The program has provided me with multiple opportunities for summer and during the year research opportunities, and allowed me to find a group of friends I resonate with, said Muchaka, who is majoring in molecular, cell and developmental biology and minoring in biomedical research. Everyone is truly there to help each other which makes it one of the most fulfilling, enriching parts of my college experience. The program helps advance your interest in the biological field but also carry you through some of the best and roughest four years of your life. Pathways is truly an innovative program and provides a foundation for college studies you won't find anywhere else.

Johnson and her co-instructor and research collaborator, Azad Hossain, are preparing to publish some of the student research in an academic journal within the next year. Pathways has enrolled more than 125 students, and these students have taken on more and more responsibility as independent researchers, mentors, tutors and campus leaders as the years have passed. Many have gone on to doctoral programs, medical school, M.D./Ph.D. programs, and a host of other STEM-related careers.

There isnt anything quite like what we do, Johnson said. I think its a model for how to think about student success.

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Dean Tracy Johnson seeks to diversify the pipeline of future scientists and doctors - UCLA Newsroom

State-of-the-Art Treatments Garner University Foot and Ankle Institute Multiple Top Doctor Awards – Yahoo Finance

By adminFebruary 2, 2021Stem Cell Doctors

TipRanks

Lets talk portfolio defense. After last weeks social flash mob market manipulation, thats a topic that should not be ignored. Now, this is not to say that the markets are collapsing. After 2% losses to close out last weeks Friday session, this weeks trading kicked off with a positive tone, as the S&P 500 rose 1.5% and the Nasdaq climbed 2.5%. The underlying bullish factors a more stable political scene, steadily progressing COVID vaccination programs are still in play, even if they are not quite as strong as investors had hoped. While increased volatility could stay with us for a while, its time to consider defensive stocks. And that will bring us to dividends. By providing a steady income stream, no matter what the market conditions, a reliable dividend stock provides a pad for your investment portfolio when the share stop appreciating. With this in mind, weve used the TipRanks database to pull up three dividend stocks yielding 8%. Thats not all they offer, however. Each of these stocks has scored enough praise from the Street to earn a Strong Buy consensus rating. New Residential Investment (NRZ) Well start by looking into the REIT sector, real estate investment trusts. These companies have long been known for dividends that are both high-yield and reliable as a result of company compliance with tax rules, that require REITs to return a certain percentage of profits directly to shareholders. NRZ, a mid-size company with a market cap of $3.9 billion, holds a diverse portfolio of residential mortgages, original loans, and mortgage loan servicing rights. The company is based in New York City. NRZ holds a $20 billion investment portfolio, which has yielded $3.4 billion in dividends since the companys inception. The portfolio has proven resilient in the face of the corona crisis, and after a difficult first quarter last year, NRZ saw rising gains in Q2 and Q3. The third quarter, the last reported, showed GAAP income of $77 million, or 19 cents per share. While down year-over-year, this EPS was a strong turnaround from the 21-cent loss reported in the prior quarter. The rising income has put NRZ in a position to increase the dividend. The Q3 payment was 15 cents per common share; the Q4 dividend was bumped up to 20 cents per common share. At this rate, the dividend annualizes to 80 cents and yields an impressive 8.5%. In another move to return profits to investors, the company announced in November that it had approved $100 million in stock repurchases. BTIG analyst Eric Hagen is impressed with New Residential especially by the companys sound balance sheet and liquidity. [We] like the opportunity to potentially build some capital through retained earnings while maintaining a competitive payout. We think the dividend increase highlights the strengthening liquidity position the company sees itself having right now we expect NRZ has been able to release capital as it's sourced roughly $1 billion of securitized debt for its MSR portfolio through two separate deals since September, Hagen opined. In line with his comments, Hagen rates NRZ a Buy, and his $11 price target implies an upside of 17% for the year ahead. (To watch Hagens track record, click here) Its not often that the analysts all agree on a stock, so when it does happen, take note. NRZs Strong Buy consensus rating is based on a unanimous 7 Buys. The stocks $11.25 average price target suggests ~20% upside from the current share price of $9.44. (See NRZ stock analysis on TipRanks) Saratoga Investment Corporation (SAR) With the next stock, we move to the investment management sector. Saratoga specializes in mid-market debt, appreciation, and equity investments, and holds over $546 million in assets under management. Saratogas portfolio is wide ranging, and includes industrials, software, waste disposal, and home security, among others. Saratoga saw a slow but steady rebound from the corona crisis. The companys revenues fell in 1Q20, and have been slowly increasing since. The fiscal Q3 report, released early in January, showed $14.3 million at the top line. In pre-tax adjusted terms, Saratogas net investment income of 50 cents per share beat the 47-cent forecast by 6%. They say that slow and steady wins the race, and Saratoga has shown investors a generally steady hand over the past year. The stock has rebounded 163% from its post-corona crash low last March. And the dividend, which the company cut back in CYQ2, has been raised twice since then. The current dividend, at 42 cents per common share, was declared last month for payment on February 10. The annualized payment of $1.68 gives a yield of 8.1%. Analyst Mickey Schleien, of Ladenburg Thalmann, takes a bullish view of Saratoga, writing, We believe SAR's portfolio is relatively defensive with a focus on software, IT services, education services, and the CLO... SAR's CLO continues to be current and performing, and the company is seeking to refinance/upsize it which we believe could provide upside to our forecast." The analyst continued, "Our model anticipates SAR employing cash and SBA debentures to fund net portfolio growth. We believe the Board will continue to increase the dividend considering the portfolio's performance, the existence of undistributed taxable income, and the economic benefit of the Covid-19 vaccination program. To this end, Schleien rates SAR a Buy along with a $25 price target. This figure implies a 20% upside from current levels. (To watch Schleiens track record, click here) Wall Streets analysts agree with Schleien on this stock the 3 other reviews on record are Buys, and the analyst consensus rating is a Strong Buy. Saratogas shares are trading for $20.87, and carry an average price target of $25.50, suggesting an upside of 22% for the next 12 months. (See SAR stock analysis on TipRanks) Hercules Capital (HTGC) Last but not least is Hercules Capital, a venture capital company. Hercules offers financing support to small, early-stage client companies with scientific bent; Hercules clients are in life sciences, technology, and financial SaaS. Since getting started in 2003, Hercules has invested over $11 billion in more than 500 companies. The quality of Hercules portfolio is clear from the companys recent performance. The stock has bounced back fully from the corona crisis of last winter, rebounding 140% from its low point reached last April. Earnings have also recovered; for the first nine months of 2020, HTGC posted net investment income of $115 million, or 11% higher than the same period of 2019. For dividend investors, the key point here is that the net investment income covered the distribution in fact, it totaled 106% of the base distribution payout. The company was confident enough to boost the distribution with a 2-cent supplemental payment. The combined payout gives a $1.28 annualized payment per common share, and a yield of 8.7%. In another sign of confidence, Hercules completed a $100 million investment grade bond offering in November, raising capital for debt pay-downs, new investments, and corporate purposes. The bonds were offered in two tranches, each of $50 million, and the notes are due in March of 2026. Covering the stock for Piper Sandler, analyst Crispin Love sees plenty to love in HTGC. We continue to believe that HTGC's focus on fast growing technology and life sciences companies sets the company up well in the current environment. In addition, Hercules is not dependent on a COVID recovery as it does not have investments in "at-risk" sectors. Hercules also has a strong liquidity position, which should allow the company to act quickly when it finds attractive investment opportunities, Love commented. All of the above convinced Love to rate HTGC an Outperform (i.e. Buy). In addition to the call, he set a $16 price target, suggesting 9% upside potential. (To watch Loves track record, click here) Recent share appreciation has pushed Hercules stock right up to the average price target of $15.21, leaving just ~4% upside from the trading price of $14.67. Wall Street doesnt seem to mind, however, as the analyst consensus rating is a unanimous Strong Buy, based on 6 recent Buy-side reviews. (See HTGC stock analysis on TipRanks) To find good ideas for dividend stocks trading at attractive valuations, visit TipRanks Best Stocks to Buy, a newly launched tool that unites all of TipRanks equity insights. Disclaimer: The opinions expressed in this article are solely those of the featured analysts. The content is intended to be used for informational purposes only. It is very important to do your own analysis before making any investment.

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State-of-the-Art Treatments Garner University Foot and Ankle Institute Multiple Top Doctor Awards - Yahoo Finance

Transforming optimism: finding new ways to treat rare cancers – Cancer Research UK – Science Blog

By adminFebruary 2, 2021Stem Cell Doctors

Cancer is an extremely complex disease. There are over 200 different types, some of which are considered common and others which are classified as rare cancers. But what exactly does it mean if a cancer is rare?

Usually, it means it only affects a small handful of people, but doctors might also call a cancer rare if it starts in an uncommon place in the body, or if the cancer is an unusual type and requires special treatment.

For secondary central nervous system (CNS) lymphoma, its an incredibly rare cancer for a combination of these reasons.

Secondary CNS lymphoma is a type of lymphoma thats spread to the brain and spinal cord nervous system after originating elsewhere in the body. And as well as being a rare cancer, secondary CNS lymphoma is an aggressive cancer, which has relatively low survival rates.

However, the latest results from the Stand Up To Cancer-funded MARIETTA clinical trial, which details a new potentially transforming treatment, has shed a glimmer of hope for patients and doctors alike.

We spoke to Dr Kate Cwynarski, who led the study in the UK, about what the latest results could mean for patients with secondary CNS lymphoma.

With a rare cancer such as secondary CNS lymphoma, finding a large enough group of patients can be a real challenge. And in cases like this, researchers have to think on a global scale.

Its a rare disease. So the reality of it is that you would not get this information if we just performed a trial in the UK, says Cwynarski. International collaboration is the only way to do it.

The MARIETTA trial is the largest study focused on patients with secondary CNS lymphoma, involving 24 centres across 4 countries and recruiting a total of 79 patients. It involved the International Extranodal Lymphoma Group (IELSG) lead by Professor Andres Ferreri in Italy and it built on the success of prior research with this group. In the UK, the trial was managed by CRUK Southampton CTU.

In particular, findings from a previous clinical trial partly funded by us, which tested treatments for primary CNS lymphoma, a lymphoma thats only found in the brain, helped inform the design of this clinical trial.

The IELSG-32 trial tested the benefits of an intensive chemotherapy regimen known as MATRIX, followed by either whole brain radiotherapy or a stem cell transplant using the patients own cells.

Cwynarski describes the IELSG-32 trial as practice changing, and its from these impressive results that the MARIETTA trial was developed. So we adapted a strategy that was successful in treating primary CNS lymphoma in the IELSG-32 trial and added another chemotherapy regimen, called R-ICE, to help treat the systemic disease on top of the secondary brain disease.

Cwynarski specialises in lymphoma, so she has treated SCNSL patients both on and off the trial. One of the big benefits of this trial, she describes, is that the inclusion criteria for the cohort more accurately reflected the patients she sees in her clinic and referral practice.

This trial included patients up to 70 years of age. And it wasnt just focused on fit, young people. So I have to say I think it was meaningful, because it included the kind of patients that we actually see.

The trial also included people regardless of when their secondary CNS lymphoma was diagnosed, whether that was when someone was originally diagnosed with lymphoma, during treatment, or after their cancer had come back.

And the results look promising. A total of 49 patients (65%) responded to the treatment in some way, with 37 people going on to have a stem cell transplant. 100% of the patients who had the stem cell transplant had not seen their cancer recur a year after registering onto the trial. We are optimistic many will be cured of this aggressive lymphoma.

But the trial also picked up differences between groups. While the regime was effective to an extent in every sub-group, the most significant results were seen in patients whose CNS disease was discovered at initial lymphoma diagnosis. Within this group, 71% of patients had lived for 2 years without their cancer growing.

A result which has never been seen before.

The results of the trial have completely transformed the teams optimism when meeting new patients. We really have identified a regimen which is intensive, but its potentially curative, concludes Cwynarski, and the word cure is not something weve really used before when talking about this disease.

Recently, Cwynarski has been busy filling out a cohort of her patients DVLA forms, confirming they are fit to drive again after being 2 years treatment free. So thats an amazing success and it was very symbolic as a reminder that these people have been alive and off all treatment for 2 years.

Moments like this are a reflection of the huge impact the MARIETTA trial has had for real people, like Maureen Brewster.

Maureen was diagnosed with lymphatic cancer of the liver in 2011 and was under the watchful eyes of a consultant during her treatment. But in the summer of 2016, I started to have very extreme headaches, says Maureen.

After getting an emergency appointment, she was taken to A&E and admitted to hospital straight away. I was transferred to the National Neurology hospital in Russell Square for a biopsy. They thought I might have had a stroke. But it wasnt. Instead, Maureen was diagnosed with a secondary cancer in her brain.

When Maureen was transferred to UCLH, she was told about the MARIETTA trial. I could have chosen not to go on the trial, but being part of it meant that I would get more examinations and monitoring. So it was more reassuring to be on the trial, she says.

Maureen during treatment.

Maureen went through 8 tough months of chemotherapy before having a stem cell transplant in the summer of 2017. During one round of chemo in the hospital I became ill with an infection and really thought I was going to die. The last chemo prior to me having stem cell transplant was so strong it really had an impact on me and I couldnt eat I felt very poorly for a few weeks.

Maureens stem cell transplant went smoothly and prior to COVID-19, she was having regular check-ups and scans in hospital.

Prior to the first lockdown in March 2020, Maureen was able to do some volunteering and also go back to work, teaching a course on Project Management at a local adult college. In April 2019 I also secured a part-time job as a User Involvement Co-ordinator. It was great to get back to that level.

Dr Cwynarski emphasises that while the trial was a great success for some, it also exposed a group of patients who didnt do so well on the treatment.

The results threw up a real disparity and uncovered an unmet need in a particular group of patients. For the group of patients whose cancer had already failed to respond to a chemotherapy treatment, known as R-CHOP, at the follow up of 2 years, only 20% had not experienced their cancer progressing or getting worse.

We need to target this cohort of patients in a different way, says Cwynarski. So really the challenge is, can we identify experimental agents be it different biological agents or immunotherapies such as CAR T cell therapy in the patients who have relapsed, and maybe bringing these therapies into the frontline.

Lilly

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Transforming optimism: finding new ways to treat rare cancers - Cancer Research UK - Science Blog

Family of Belfast woman Eimear Gooderham (25) share memories and dealing with grief in special UTV programme – Belfast Telegraph

By adminFebruary 2, 2021Stem Cell Doctors

The story of Belfast woman Eimear Gooderham (nee Smyth), who passed away after a brave battle with cancer and sparked awareness of the stem cell register in Northern Ireland, will be told in a UTV programme this week.

imear was diagnosed with Hodgkins Lymphoma, a type of blood cancer, in 2016 aged 22 and underwent a dozen rounds of chemotherapy.

She manage to beat the cancer in the spring of 2017 and was given the all-clear by doctors, only for the disease to return again a few weeks later.

The disease went into remission following an autologous stem cell transplant, which involved using her own cells and high-dose chemotherapy.

In 2018, however, the Hodgkins Lymphoma returned once again and doctors said Eimear required another stem cell transplant, but from an anonymous donor.

This prompted her father Sean to launch a campaign, alongside UTV, to get people to sign the stem cell register and eventually a match was found.

Eimear had surgery, but sadly she passed away in hospital of organ failure on June 27, 2019, after suffering complications.

She had been due to marry her fianc Phillip Gooderham in October 2019, however with her condition worsening the wedding was organised to take place in hospital before she passed away.

UTV presenter Sarah Clarke followed Eimears story from the summer of 2018 and now that story will be told in a special programme, Eimears Wish, airing this Thursday at 10.45pm.

The programme will feature extracts from her video diary and dad Sean and sister Seainin, share memories of Eimear and talk about the positive ways they have been dealing with their grief since she passed away.

Sean Smyth said he hopes the programme will highlight the need for more people in Northern Ireland to join the stem cell donor register, especially men aged between 16 and 30.

There is also a lack of age-appropriate care for teenagers and young adults with life threatening illnesses such as blood cancer, he said.

The current facilities and the environment in which our teenagers and young adults receive their treatment and care is very poor. There also needs to be better facilities for the childrens carers.

Sarah Clarke added: It was Eimears dying wish to raise awareness of stem cell donation and to help further research into the treatment to help others. And although this programme is an entirely different one from the one we set out to make, I hope that it will in some way help to do that.

Belfast Telegraph

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Family of Belfast woman Eimear Gooderham (25) share memories and dealing with grief in special UTV programme - Belfast Telegraph

Experts Predict the Hottest Life Science Tech in 2021 and Beyond – The Scientist

By adminFebruary 2, 2021Somatic Stem Cells

Through the social and economic disruption that COVID-19 caused in 2020, the biomedical research community rose to the challenge and accomplished unprecedented feats of scientific acumen. With a new year ahead of us, even as the pandemic grinds on, we at The Scientist thought it was an opportune time to ask what might be on the life science innovation radar for 2021 and beyond. We tapped three members of the independent judging panel that helped name our Top 10 Innovations of 2020 to share their thoughts (via email) on the year ahead.

Paul Blainey: Value is shifting from the impact of individual technologies (mass spectrometry, cloning, sequencing, PCR, induced pluripotent stem cells, next generation sequencing, genome editing, etc.) to impact across technologies. In 2021, I think researchers will increasingly leverage multiple technologies together in order to generate new insights, as well as become more technology-agnostic as multiple technologies present plausible paths toward research goals.

Kim Kamdar: Partially in reaction to the COVID-19 pandemic, one 2021 headline will be the continued innovation focused on consumerization of healthcare, which is redefining how consumers engage with providers across each stage of care. Consumers are even selective about their healthcare choices now, and the retail powerhouses like CVS and Walmart have and will continue to develop solutions to meet the needs of their customers. While this was already underway prior to the pandemic, the crisis has spurred on this activity with the goal of making healthcare more accessible and affordable and ultimately delivering on better health outcomes for all Americans.

Robert Meagher: I think this is easymRNA delivery. This is something that has been in development for years for numerous applications, but the successful development and FDA emergency use authorization of two COVID-19 vaccines based on this technology shines a very bright spotlight on this technology. The vaccine trials and now widespread use of the vaccines will give developers a lot of data about the technology, and sets a baseline for understanding safety and side effects when considering future therapeutic applications outside of infectious disease.

PB:Single-cell technology is here to stay, although its use will continue to change. One analogy to be drawn is the shift we saw from the popularity ofde novo genome sequencing (during the human genome project and the early part of the NGS [next-generation sequencing] era to the rich array of re-sequencing applications practiced today. I expect new ways to use single-cell technology will continue to be discovered for some time to come.

KK: Innovation in single-cell technology has the potential to transform biological research driving to a level of resolution that provides a more nuanced picture of complex biology. Cost has been a key barrier for broader adoption of single-cell analysis. As better technology is developed, cost will be reduced and there will be an explosion in single-cell research. This dynamic will also allow for broader adoption of single-cell technology from translational research to clinical applications particularly in oncology and immunology.

RM: Yesthere is continuing innovation in this space, and room for continued innovation. One area that we have seen development recently, and I see it continuing, is to study single cells not just in isolation, but coupled with spatial information: understanding single cells and their interactions with their neighbors. I also wonder if the COVID-19 pandemic will spur increased interest in applying single-cell techniques to problems in infectious disease, immunology, and microbiology. A lot of the existing methods for single-cell RNA analysis (for example) work well for human or mammalian cells, but dont work for bacteria or viruses.

PB: The promises of CRISPR and gene editing are extraordinary. I cant wait to see how that field continues to develop.

KK: Much of the CRISPR technology focus since it was unveiled in 2012 has been on its utility to modify genes in human cells with the goal of treating genetic disease. More recently, scientists have shown the potential of using the CRISPR gene-editing technology for treatment of viral disease (essentially a programmable anti-viral that could be used to treat diseases like HIV, HBV, SARS, etc. . . .). These findings, published in Nature Communications, showed that CRISPR can be used to eliminate simian immunodeficiency virus (SIV) in rhesus macaque monkeys. If replicated in humans, in studies that will be initiated this year, CRISPR could be utilized to address HIV/AIDS and potentially make a major impact by moving a chronic disease to one with a functional cure.

PB: New therapeutic modalities that expand the addressable set of diseases are particularly exciting. Cell-based therapies offer versatile platforms for biological engineering that leverage the power of human biology. It is also encouraging to see somatic cell genome editing technology advance toward the clinic for the treatment of serious diseases.

The level of innovation that occurred in 2020 to combat COVID-19 will provide a more rapid, focused, and actionable reaction to future pandemics.

Kim Kamdar, Domain Associates

RM: Besides the great success with mRNA-based vaccines that sets the stage for other clinical technologies based on mRNA delivery, the other area that is really in the spotlight this year is diagnostics. There are a lot of labs and companies, both small and large, that have some really innovative products and ideas for portable and point-of-care diagnostics. For a long time, this was often thought of in terms of a problem for the developing world, or resource-limited locations: think, for example, of diagnostics for neglected tropical diseases. But the COVID-19 pandemic and the associated need for diagnostic testing on a massive scale has caused us to rethink what resource-limited means, and to understand the challenge posed by bottlenecks in supply chains, skilled personnel, and high-complexity laboratory facility. There has been a lot of foundational research over the past couple of decades in rapid, portable, easy-to-use diagnostics, but translating these to clinically useful products often seemed to stall, I suspect for lack of a lucrative market for such tests. But we are now starting to see FDA [emergency use authorization for] home-based tests and other novel diagnostic technologies to address needs with the COVID-19 pandemic, and I suspect that this paves the way for these technologies to start being applied to other diagnostic testing needs.

PB: Seeing the suffering and destruction wrought by COVID-19, it is obvious that we need to be prepared with more extensive, equitable, and better-coordinated response plans going forward. While rapid vaccine development and testing were two bright spots last year, there are so many important areas that demand progress. As we learn about how important details become in a crisisno matter how small or mundanediagnostic technologies and the calibration of public health measures are two areas that merit major focus.

KK: The life science community response to the COVID-19 pandemic has already proven to be light-years ahead of previous responses particularly in areas such as vaccine development and diagnostics. It took more than a year to sequence the genome of the SARS virus in 2002. The COVID-19 genome was sequenced in under a month from the first case being identified. Scientists and clinicians were able to turn that initial information to multiple approved vaccines at a blazing speed. Utilizing messenger RNA (mRNA) as a new therapeutic modality for vaccine development has now been validated. Vaccine science has been forever changed. The pandemic has also focused a much-needed level of attention to diagnostics, forcing a rethink of how to increase access, affordability, and actionability of diagnostic testing. The level of innovation that occurred in 2020 to combat COVID-19 will provide a more rapid, focused, and actionable reaction to future pandemics. In addition, the elevation of a science advisor (Dr. Eric Lander) to a cabinet level position in the Biden administration bodes well for our future ability to ground in data and as President Biden himself framed, refresh and reinvigorate our national science and technology strategy to set us on a strong course for the next 75 years, so that our children and grandchildren may inhabit a healthier, safer, more just, peaceful, and prosperous world.

RM: One thing that really kick-started research to address COVID-19 was the early availability of the complete genome sequence of the SARS-CoV-2 virus, and the ongoing timely deposition of new sequences in nearreal-time as isolates were sequenced. This is in contrast to cases where deposition of large number of sequences may lag an outbreak by months or even years. I foresee the nearreal-time sharing of sequence information to become the new standard. Making the virus itself widely and inexpensively available, in inactivated form, as well as well-characterized synthetic viral RNA standards and proteins also helped spur research.

A trend Im less fond of is the rapid publication of nonpeer reviewed results as preprints online. Theres a great benefit to getting new information out to the community ASAP, but unfortunately I think the rush to get preprints up in some cases results in spreading misleading information. This problem is compounded with uncritical, breathless press releases accompanying the posting of preprints, as opposed to waiting for peer-review acceptance of a manuscript to issue a press release. I think the solution may lie in journals considering innovative approaches to speeding up peer review, or a way to at least perform a basic check for rigor prior to posting a preliminary version of the manuscript. Right now the extremes are: post an unreviewed preprint, or wait months or even years with multiple rounds of peer review including extensive additional experiments to satisfy the curiosity of multiple reviewers for high impact publications. Is there a way to prevent manuscripts from being published as preprints with obvious methodological errors or errors in statistical analysis, while also enabling interesting, well-done yet not fully polished manuscripts to be available to the community?

Paul Blaineyis an associate professor of biological engineering at MIT and a core member of the Broad Institute of MIT and Harvard University. The Blainey lab integrates new microfluidic, optical, molecular, and computational tools for application in biology and medicine. The group emphasizes quantitative single-cell and single-molecule approaches, aiming to enable studies that generate data with the power to reveal the workings of natural and engineered biological systems across a range of scales. Blainey has a financial interest in several companies that develop and/or apply life science technologies: 10X Genomics, GALT, Celsius Therapeutics, Next Generation Diagnostics, Cache DNA, and Concerto Biosciences.

Kim Kamdaris managing partner at Domain Associates, a healthcare-focused venture fund creating and investing in biopharma, device, and diagnostic companies. She began her career as a scientist and pursued drug-discovery research at Novartis/Syngenta for nine years.

Robert Meagheris a principal member of Technical Staff at Sandia National Laboratories. His main research interest is the development of novel techniques and devices for nucleic acid analysis, particularly applied to problems in infectious disease, biodefense, and microbial communities. Most recently this has led to approaches for simplified molecular diagnostics for emerging viral pathogens that are suitable for use at the point of need or in the developing world. Meaghers comments represent his professional opinion but do not necessarily represent the views of the US Department of Energy or the United States government.

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Experts Predict the Hottest Life Science Tech in 2021 and Beyond - The Scientist

Stem Cell Therapy Market to Score Past US$ 40.3 Billion Valuation by 2027: At a CAGR of 21.1% KSU | The Sentinel Newspaper – KSU | The Sentinel…

By adminFebruary 2, 2021Adult Stem Cells

GlobalStem Cell Therapy Market,by Cell Source (Adult Stem Cells, Induced Pluripotent Stem Cells, Embryonic Stem Cells, and Others), by Application (Musculoskeletal Disorders, Wounds and Injuries, Cancer, Autoimmune Disorders, and Others), and byRegion(North America, Latin America, Europe, Asia Pacific, Middle East, and Africa),was valued atUS$ 7,313.6million in 2018, and is expected to exhibit a CAGR of21.1%over the forecast period (2019-2027),as highlighted in a new report published by .Increasing application of stem cells for the treatment of patients with blood-related cancers, spinal cord injury and other diseases are the leading factors that are expected to drive growth of stem cell therapy market over the forecast period.

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According to the National Spinal Cord Injury Statistical Center, 2016, the annual incidence of spinal cord injury (SCI) is approximately 54 cases per million population in the U.S. or approximately 17,000 new SCI cases each year. Moreover, according to the Leukemia and Lymphoma Society, 2017, around 172,910 people in the U.S. were diagnosed with leukemia, lymphoma or myeloma in 2017, thus leading to increasing adoption of stem cells for its efficient treatment. Increasing product launches by key players such as medium for developing embryonic stem cells is expected to propel the market growth over the forecast period.

For instance, in January 2019, STEMCELL Technologies launched mTeSR Plus, a feeder-free human pluripotent stem cell (hPSC) maintenance medium for avoiding conditions associated with DNA damage, genomic instability, and growth arrest in hPSCs. With the launch of mTeSR, the company has expanded its portfolio of mediums for maintenance of human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells.

Increasing research and development of induced pluripotent stem cells coupled with clinical trials is expected to boost growth of the stem cell therapy market over the forecast period. For instance, in April 2019, Fate Therapeutics in collaboration with UC San Diego researchers launched Off-the-shelf immunotherapy (FT500) developed from human induced pluripotent stem cells. The therapy is currently undergoing clinical trials for the treatment of advanced solid tumors.

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North America is expected to hold a dominant position in the stem cell therapy market over the forecast period, owing increasing number of clinical trials to cater to unmet medical needs of the patients is a major factor driving growth of the stem cell therapy market. For instance, in April, 2019, UCLA-UCI Alpha Stem Cell Clinic participated in a new clinical research study to investigate a stem cell product CTX0E03 DP, in order to improve function in people with chronic disability from ischemic stroke. The study, called PISCES III, is currently in phase IIb clinical study. Moreover, manufacturers are focused on collaborating with academic researchers to help expand the potential use of newborn stem cell therapies that may be available to patients, which is expected to facilitate growth of the market over the forecast period. For instance, in February 2018, the Institute of Integrative Biology entered into a collaboration with Anika Therapeutics, Inc., to develop an injectable mesenchymal stem cell (MSC) therapy for the treatment of osteoarthritis in patients.

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Reduced Adult Neurogenesis Linked with Alzheimers Disease – The Scientist

By adminFebruary 2, 2021Adult Stem Cells

Charlie Arber, a stem cell biologist at University College London, works with induced pluripotent stem cell models of inherited forms of dementia. When he and his colleagues started studying several cell lines derived from patients with familial forms of Alzheimers disease a few years ago, one of the first things that they noticed was that the cells developed into neurons more quickly than stem cells derived from healthy individuals did, he says.

The researchers looked more closely at the Alzheimers cell lines and, in a study published January 12 in Cell Reports, confirmed that neurogenesisthe production of neurons from precursorsin these lines does happen much sooner. When they looked in the brains of familial Alzheimers patients after death, they found fewer newborn neurons than in the brains of healthy donors, indicating that the premature neurogenesis observed in stem cell lines is likely a feature of familial Alzheimers disease that leads to bursts of newborn neurons in early adulthood followed by defects in neurogenesis as people age.

Well before this study, scientists have suspected that adult neurogenesis and Alzheimers disease are linked. In 1998, Rusty Gage, a neuroscientist at the Salk Institute, and colleagues examined human brains postmortem and found evidence for adult neurogenesis in the hippocampus, the brain center linked with learning, memory, and emotional responsesseveral of the cognitive tasks that are disrupted in Alzheimers disease. The birth of neurons had been previously shown in rodents and nonhuman primates, but not people.

Since then, work in animal models and people has indicated that adult hippocampal neurogenesis plays an important role in memory formation and that decreases in neurogenesis accompany aging, as well as cognitive loss and the development of Alzheimers disease, which affects 10 percent of Americans older than 65. But scientists are still figuring out at what point in disease onset or progression adult hippocampal neurogenesis plays a role and whether or not tweaking neurogenesis could help treat or prevent the disease.

Neural stem cells in the granule cell layer (GCL) and subgranular layer (SGL) of the dentate gyrus of the hippocampus are indicated by arrows. Cell nuclei are blue.

Ahmed Disouky

Researchers have been making progress looking directly at neurogenesis in people, but their efforts are not without challenges.

As a graduate student, Mara Llorens-Martn, now a neuroscientist at the Autonomous University of Madrid, showed that increasing adult neurogenesis had neuroprotective effects on mice that were cognitively impaired. Then, as a postdoc about 10 years ago, she started collecting human brain samples to study adult neurogenesis in people. But she quickly realized that the samples that are available in most brain banks are not suitable for studying adult neurogenesis because of how theyre processed and preserved.

When the researchers compared healthy subjects with patients who had cognitive impairmentin particular, those with Alzheimers diseasethe reduction in the number of new neurons was dramatic.

When a brain is donated to a brain bank, the standard procedure usually involves immersing the tissue in fixative for several weeks, which later allows researchers to cut thin tissue sections and image them. But that lengthy process fixes telltale markers of newborn neurons so that the antibodies researchers use to detect them dont work on the samples, Llorens-Martn explains.

When the researchers fixed brains for 24 hours instead, they were able to detect evidence of neurogenesis in the hippocampus. In a study published in 2019, Llorens-Martn and her colleagues confirmed prior work showing that adult neurogenesis gradually decreases with age, even in healthy people. And when the researchers compared healthy subjects with patients who had cognitive impairmentin particular, those with Alzheimers diseasethe reduction in the number of new neurons was dramatic. Even in very young subjects that were diagnosed as Alzheimers disease patients, the number of new neurons was very much reduced compared to the neurologically healthy aged subjects, she says.

In another 2019 study, a group led by Orly Lazarov, a neuroscientist at the University of Illinois at Chicago, examined the postmortem hippocampi of 18 people between 79 and 99 years old. They found evidence of neurogenesis in all subjects, including those diagnosed with mild cognitive impairment or Alzheimers disease. The number of neural progenitors and newborn neurons was associated with cognitive status: people with higher numbers of these cells generally had higher cognitive scores and a less severe diagnosis.

Theres more and more evidence to suggest that adult hippocampal neurogenesis plays a major role in Alzheimers disease cognitive decline, says Lazarov. Her work and that of others has shown that neurogenesis is impaired early in Alzheimers disease (AD). In mouse models, for instance, her group has found differences in neurogenesis as early as two and three months of agethe equivalent of a person in their 20s. They and others have also found that further depleting neurogenesis exacerbates cognitive defects in AD rodent models. Its possible that impairments in neurogenesis are not just a side effect of AD pathology, she says, but part of the mechanism by which memory is impaired in the disease.

In their latest paper, Arber and colleagues show that neurogenesis in induced pluripotent stem cells looks similar to what happens in the human brain, meaning that stem cell models could help address the question of cause or effect. And if indeed defects in neurogenesis are driving neurodegeneration, a new avenue to intervention opens up.

All cells in a human brain organoid are labeled in blue and newborn neurons are in red.

Charles Arber, Selina Wray, Christopher Lovejoy

We diagnose people at seventy years old or seventy-five years old. Thats too late to intervene, says Caghan Kizil, a neuroscientist at the German Center for Neurodegenerative Diseases. But we know that the molecular or pathological onset starts much earlier, he adds, and that means theres a chance scientists and physicians could stall the process, perhaps by tweaking neurogenesis.

In a study published in January 2020, Kizil and colleagues identified two different populations of neural stem cells that respond to signaling pathways that regulate neurogenesis in a zebrafish model of Alzheimers disease. They found a role for brain-derived neurotrophic factor (BDNF), a protein that when elevated was also implicated in cognitive improvements in a mouse model of Alzheimers disease. BDNF supports neuron survival, maturation, and maintenance in healthy brains. In the study, Rudolph Tanzi, a neuroscientist at Harvard University, Gage, and colleagues improved cognition in the animals by stimulating neurogenesis either genetically or with drugs and artificially raising BDNF levels in the hippocampus. The findings indicate that manipulating neurogenesis and tweaking neuron survival could be a possible treatment for Alzheimers disease.

Even if researchers develop therapeutics that block or reduce the progression of the disease, they will not reverse the damage, says Nicolas Toni, a neuroscientist at Lausanne University Hospital in Switzerland and a former Gage lab postdoc. Neural death has already occurred once the patient recognizes he or she has memory issues, and these neurons are lost, he says, but adult neurogenesis in the hippocampus could be a way to partially right that wrong. The most important question is, can we manipulate adult neurogenesis? And is that sufficient to alleviate some of the symptoms of Alzheimers disease?

Developing pharmaceuticals that increase neurogenesis and an inexpensive, live-imaging strategy or a diagnostic test that can directly link neurogenesis and cognition in people will be important steps, but far in the future, Gage says. At least in rodents, where increased neurogenesis has positive impacts, theres very little evidence that you can hurt yourself by increasing your neurogenesis, but theres always [safety] as a concern, he adds.

The most difficult question to answer, according to Llorens-Martn, is what happens to the few new neurons that are born in the brains of people with neurodegeneration. What is failing in the environment that is making these neurons die prematurely or making it very difficult for them to get connected appropriately? she says. It is known that systemic changes occur in in blood, for example, in Alzheimers disease patients several decades before the appearance of the cognitive impairments, she says. Its possible that those changes in the systemic environment or the environment of the brain are somehow decreasing the neurogenic potential of the hippocampus, she adds.

We know that neurogenesis is critical for learning and memory, and we know that the level of neurogenesis decreases with age no matter what, even in normal aging, says Lazarov. And if we maintain [a] greater level of neurogenesis . . . we would be able to maintain greater hippocampal plasticity and intact hippocampal function. This may delay Alzheimers disease greatly.

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Reduced Adult Neurogenesis Linked with Alzheimers Disease - The Scientist

Regenerative Medicine (Bone and Joint) Market to Score Past US$ 14990.0 Million Valuation by 2027: CMI KSU | The Sentinel Newspaper – KSU | The…

By adminFebruary 2, 2021Adult Stem Cells

Regenerative medicines are medical products or active pharmaceutical ingredients that have the ability to cure or replace organs and tissues organs damaged by various factors such as aging, diseases, trauma, and can also be used to provide stability in congenital disorders. Regenerative medicine for bone and joint is considered an emerging and promising field.

Statistics:

The globalregenerative medicine (bone and joint) marketis estimated to account forUS$ 7,189.8 Mnin terms of value in2020and is expected to reachUS$ 14,990.0 Mnby the end of2027.

GlobalRegenerative Medicine (Bone and Joint)Market: Drivers

Approval and launch of new products is expected to propel growth of the global regenerative medicine (bone and joint) market over the forecast period. For instance, in January 2020, Carmell Therapeutics received clearance from the U.S. Food and Drug Administration (U.S. FDA) for Investigational New Drug Application for the companys first product, which is a bone healing accelerant (BHA).

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GlobalRegenerative Medicine (Bone and Joint)Market: Opportunities

R&D of new products is expected to offer lucrative growth opportunities for players in the global regenerative medicine (bone and joint) market. For instance, in June 2019, Personalized Stem Cells, Inc. submitted an Investigational New Drug Application (IND) to the U.S. FDA for utilizing patients own adipose-derived stem cells to treat their osteoarthritis.

GlobalRegenerative Medicine (Bone and Joint)Market: Restraints

Ethical issues and post implantation infections are hindering growth of the global regenerative medicine (bone and joint) market. Utilization of adult stem cell for research and derivation of stem cell from excess in-vitro fertilization embryo does not pose any ethical concern. However, creation of embryo for research is an ethical concern and is prohibited. Moreover, utilization of adult stem cell for commercial purposes has become a threat to mankind and is considered as an ethical issue worldwide.

Key Takeaways:

The global regenerative medicine (bone and joint) market was valued atUS$ 6,473.4 Mnin2019and is forecast to reach a value ofUS$ 14,990.0 Mnby2027at aCAGR of 11.1%between2020 and 2027. Major factor driving the growth of global regenerative medicine (bone and joint) market during the forecast period include technological advancement, and increasing prevalence of musculoskeletal disorders.

Biomaterial held dominant position in the global regenerative medicine (bone and joint) market in 2019, accounting for62.7%share in terms of value, followed by Stem Cell and Tissue Engineering, respectively. Increasing use of regenerative medicine is expected to support growth of the segment over the forecast period.

Market Trends

High prevalence of rheumatoid arthritis is expected to propel growth of the global regenerative medicine (bone and joint) market over the forecast period. For instance, according to results of a systematic analysis published in the Annals of the Rheumatic Diseases in October 2019, the global prevalence of rheumatoid arthritis was 19,965,115 in 2017, with an age-standardized prevalence rate of 246.6 cases/100,000 population, which increased by 7.4% between 1990 and 2017.

Major players in the global regenerative medicine (bone and joint) market are focused on approval and launch of new products to expand their product portfolio. For instance, in January 2020, Royal Biologics launched Magnus viable cellular bone matrix, which is an osteoconductive bone scaffold and is composed of demineralized cortical, mineralized cortical, and cancellous bone that is stored in a DMSO-free cryoprotectant.

GlobalRegenerative Medicine (Bone and Joint)Market: Competitive Landscape

Major players operating in the global regenerative medicine (bone and joint) market include, Anika Therapeutics, Inc., Arthrex, Inc., Baxter International, Inc., CONMED Corporation, DePuy Synthes, Inc., Medtronic, Plc, Smith & Nephew plc, Stryker Corporation, Zimmer Holdings, Inc., Aziyo Biologics, and Ortho Regenerative Technologies Inc.

GlobalRegenerative Medicine (Bone and Joint)Market: Key Developments

Major players in the global regenerative medicine (bone and joint) market are focused on adopting various strategies to enhance their market share. For instance, in August 2020, Ortho Regenerative Technologies Inc. announced the closing of a non-brokered US$ 2.5 million private placement of units.

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Segmentation

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Regenerative Medicine (Bone and Joint) Market to Score Past US$ 14990.0 Million Valuation by 2027: CMI KSU | The Sentinel Newspaper - KSU | The...

Orthopedic Regenerative Medicine Market Size to Witness A Lucrative Growth Over 2020-2027 | Curasan, Inc., Carmell Therapeutics Corporation, Anika…

By adminFebruary 2, 2021Adult Stem Cells

The Report Titled on Orthopedic Regenerative Medicine Market which provides COVID19 Impact analysis on Market Size (Production, Capacity, Value, Values & Consumption), Regional and Country-Level Market Size, Segmentation Market Growth, Market Share, Competitive Landscape, Sales Analysis, Impact of Domestic and Market Players. Orthopedic Regenerative Medicine Market detailed study of historical and present/future market data. Economic growth, GDP (Gross Domestic Product), and inflation are some of the elements included in this report to offer crystal clear picture of the Orthopedic Regenerative Medicine industry at global level.

Orthopedic Regenerative Medicine Market competitive landscapes provides details by topmost manufactures like (Curasan, Inc., Carmell Therapeutics Corporation, Anika Therapeutics, Inc., Conatus Pharmaceuticals Inc., Histogen Inc., Royal Biologics, Ortho Regenerative Technologies, Inc., Swiss Biomed Orthopaedics AG, Osiris Therapeutics, Inc., and Octane Medical Inc.), including Capacity, Production, Price, Revenue, Cost, Gross, Gross Margin, Growth Rate, Import, Export, Market Share and Technological Developments.

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Market Segmentation & Coverage:

This research report categorizes the Orthopedic Regenerative Medicine to forecast the revenues and analyze the trends in each of the following sub-markets:

By Procedure Cell TherapyTissue EngineeringBy Cell TypeInduced Pluripotent Stem Cells (iPSCs)Adult Stem CellsTissue Specific Progenitor Stem Cells (TSPSCs),Mesenchymal Stem Cells (MSCs)Umbilical Cord Stem Cells (UCSCs)Bone Marrow Stem Cells (BMSCs)By SourceBone MarrowUmbilical Cord BloodAdipose TissueAllograftsAmniotic FluidBy ApplicationsTendons RepairCartilage RepairBone RepairLigament RepairSpine RepairOthers

Based on Geography, the Orthopedic Regenerative Medicine Market studied across Americas, Asia-Pacific, and Europe, Middle East & Africa. The Americas region surveyed across Argentina, Brazil, Canada, Mexico, and United States. The Asia-Pacific region surveyed across Australia, China, India, Indonesia, Japan, Malaysia, Philippines, South Korea, and Thailand. The Europe, Middle East & Africa region surveyed across France, Germany, Italy, Netherlands, Qatar, Russia, Saudi Arabia, South Africa, Spain, United Arab Emirates, and United Kingdom.

Impact of COVID-19 on this Market:

The pandemic of COVID-19 continues to expand and impact over 175 countries and territories. Although the outbreak appears to have slowed in China, COVID-19 has impacted globally. The pandemic could affect three main aspects of the global economy: production, supply chain, and firms and financial markets. National governments have announced largely uncoordinated, country-specific responses to the virus. As authorities encourage social distancing and consumers stay indoors, several businesses are hit. However, coherent, coordinated, and credible policy responses are expected to offer the best chance at limiting the economic fallout.

We, at Coherent Market Insights, understand the economic impact on various sectors and markets. Using our holistic market research methodology, we are focused on aiding your business sustain and grow during COVID-19 pandemics. With deep expertise across various industries-no matter how large or small- and with a team of highly experienced and dedicated analysts, Coherent Market Insights will offer you an impact analysis of coronavirus outbreak across industries to help you prepare for the future.

The Orthopedic Regenerative Medicine Market on the basis of Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) that aids businesses in better decision making and understanding the competitive landscape.

Competitive Strategic Window:

Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies. Competitive Strategic Window helps the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. During a forecast period, it defines the optimal or favorable fit for the vendors to adopt successive merger and acquisition strategies, geography expansion, research & development, and new product introduction strategies to execute further business expansion and growth.

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The report provides insights on the following pointers:

Market Penetration: Provides comprehensive information on the market offered by the key players

Market Development: Provides in-depth information about lucrative emerging markets and analyzes the markets

Market Diversification: Provides detailed information about new product launches, untapped geographies, recent developments, and investments

Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, and manufacturing capabilities of the leading players

Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and new product developments

The report answers questions such as:

What is the market size and forecast of the Global Orthopedic Regenerative Medicine Market?

What are the inhibiting factors and impact of COVID-19 shaping the Global Orthopedic Regenerative Medicine Market during the forecast period?

Which are the products/segments/applications/areas to invest in over the forecast period in the Global Orthopedic Regenerative Medicine Market?

What is the competitive strategic window for opportunities in the Global Orthopedic Regenerative Medicine Market?

What are the technology trends and regulatory frameworks in the Global Orthopedic Regenerative Medicine Market?

What are the modes and strategic moves considered suitable for entering the Global Orthopedic Regenerative Medicine Market?

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Orthopedic Regenerative Medicine Market Size to Witness A Lucrative Growth Over 2020-2027 | Curasan, Inc., Carmell Therapeutics Corporation, Anika...